GO.ID	Description	p.Val	FDR	Phenotype	Genes
GO:0051171	regulation of nitrogen compound metabolic process	1.2667134614255474e-31	1.2667134614255474e-31	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,STK11,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0080090	regulation of primary metabolic process	6.2309286431592925e-31	6.2309286431592925e-31	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,STK11,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0060255	regulation of macromolecule metabolic process	2.9452991934363835e-30	2.9452991934363835e-30	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,STK11,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0031323	regulation of cellular metabolic process	2.9452991934363835e-30	2.9452991934363835e-30	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,STK11,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0019222	regulation of metabolic process	3.6923671797286285e-28	3.6923671797286285e-28	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,STK11,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0051173	positive regulation of nitrogen compound metabolic process	3.2749021091849606e-27	3.2749021091849606e-27	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,ATR,VEZF1,CDK12,PTPN11,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,ERCC2,EZH2,PCBP1
GO:0019219	regulation of nucleobase-containing compound metabolic process	1.1042422057016804e-25	1.1042422057016804e-25	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0010556	regulation of macromolecule biosynthetic process	1.777191496845136e-25	1.777191496845136e-25	+1	TP53,PTEN,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,EZH2,PCBP1
GO:0031326	regulation of cellular biosynthetic process	9.398217533225495e-25	9.398217533225495e-25	+1	TP53,PTEN,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,EZH2,PCBP1
GO:0010468	regulation of gene expression	1.0652323020493078e-24	1.0652323020493078e-24	+1	TP53,PTEN,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,EZH2,PCBP1
GO:0010604	positive regulation of macromolecule metabolic process	1.0652323020493078e-24	1.0652323020493078e-24	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,ATR,VEZF1,CDK12,PTPN11,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,ERCC2,EZH2,PCBP1
GO:0009889	regulation of biosynthetic process	1.1120093986552041e-24	1.1120093986552041e-24	+1	TP53,PTEN,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,EZH2,PCBP1
GO:0006351	DNA-templated transcription	1.4266421854135512e-24	1.4266421854135512e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0032774	RNA biosynthetic process	2.5068232128366595e-24	2.5068232128366595e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0006355	regulation of DNA-templated transcription	3.825043570373833e-24	3.825043570373833e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,EZH2,PCBP1
GO:2001141	regulation of RNA biosynthetic process	5.2941977849811526e-24	5.2941977849811526e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,EZH2,PCBP1
GO:0034654	nucleobase-containing compound biosynthetic process	6.625387489746716e-24	6.625387489746716e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0016310	phosphorylation	6.726178627180523e-24	6.726178627180523e-24	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,AXIN2,CDKN2C,EZH2
GO:0018130	heterocycle biosynthetic process	1.907363179560382e-23	1.907363179560382e-23	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0019438	aromatic compound biosynthetic process	2.1547757547654856e-23	2.1547757547654856e-23	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0048522	positive regulation of cellular process	2.75366663498839e-23	2.75366663498839e-23	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,CBFB,ATR,SIN3A,VEZF1,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0051252	regulation of RNA metabolic process	3.090649822824451e-23	3.090649822824451e-23	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,RAD21,EZH2,PCBP1
GO:1901362	organic cyclic compound biosynthetic process	1.5134458906351425e-22	1.5134458906351425e-22	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0006468	protein phosphorylation	1.5134458906351425e-22	1.5134458906351425e-22	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,STK11,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,AXIN2,CDKN2C,EZH2
GO:0009893	positive regulation of metabolic process	1.5232957543809866e-22	1.5232957543809866e-22	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,ATR,VEZF1,CDK12,PTPN11,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,ERCC2,EZH2,PCBP1
GO:0031325	positive regulation of cellular metabolic process	2.928531968202854e-22	2.928531968202854e-22	+1	TP53,VHL,KRAS,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,ATR,VEZF1,CDK12,PTPN11,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,ERCC2,EZH2,PCBP1
GO:0044271	cellular nitrogen compound biosynthetic process	2.980223631196888e-22	2.980223631196888e-22	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0048518	positive regulation of biological process	9.500521562072145e-22	9.500521562072145e-22	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,CBFB,ATR,SIN3A,VEZF1,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0090304	nucleic acid metabolic process	9.979662659714244e-22	9.979662659714244e-22	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0044237	cellular metabolic process	2.1302015229090605e-21	2.1302015229090605e-21	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,IDH1,TBX3,MAP2K4,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0009892	negative regulation of metabolic process	2.1632389773050164e-21	2.1632389773050164e-21	+1	TP53,PIK3CA,PTEN,APC,VHL,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,STK11,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,PHF6,PTPN11,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0043170	macromolecule metabolic process	4.067477575427836e-21	4.067477575427836e-21	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0031324	negative regulation of cellular metabolic process	4.3255249476527605e-21	4.3255249476527605e-21	+1	TP53,PIK3CA,PTEN,APC,VHL,NAV3,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,PHF6,PTPN11,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0016070	RNA metabolic process	4.3255249476527605e-21	4.3255249476527605e-21	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0006139	nucleobase-containing compound metabolic process	4.3255249476527605e-21	4.3255249476527605e-21	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,IDH1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0010467	gene expression	5.777824616604978e-21	5.777824616604978e-21	+1	TP53,PTEN,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0048519	negative regulation of biological process	9.043622015017071e-21	9.043622015017071e-21	+1	TP53,PIK3CA,PTEN,APC,VHL,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,MECOM,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0045893	positive regulation of DNA-templated transcription	1.1133362166524004e-20	1.1133362166524004e-20	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,SF3B1,TAF1,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,SMAD2,PCBP1
GO:1902680	positive regulation of RNA biosynthetic process	1.2373523735595589e-20	1.2373523735595589e-20	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,SF3B1,TAF1,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,SMAD2,PCBP1
GO:0048523	negative regulation of cellular process	1.5213768087226553e-20	1.5213768087226553e-20	+1	TP53,PIK3CA,PTEN,APC,VHL,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,MECOM,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0034641	cellular nitrogen compound metabolic process	3.365741447727715e-20	3.365741447727715e-20	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,IDH1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0046483	heterocycle metabolic process	3.5630504612836954e-20	3.5630504612836954e-20	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,IDH1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0009059	macromolecule biosynthetic process	4.893022532669564e-20	4.893022532669564e-20	+1	TP53,PTEN,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0006725	cellular aromatic compound metabolic process	4.893022532669564e-20	4.893022532669564e-20	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,IDH1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0006807	nitrogen compound metabolic process	4.893022532669564e-20	4.893022532669564e-20	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,IDH1,TBX3,RPL22,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	5.788420919671517e-20	5.788420919671517e-20	+1	TP53,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,ASXL1,SOX17,SF3B1,TAF1,ATR,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,SMAD2,ERCC2,PCBP1
GO:0019220	regulation of phosphate metabolic process	6.742762217371941e-20	6.742762217371941e-20	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,FLT3,NPM1,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,EP300,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,NCOR1,AXIN2,CDKN2C,EZH2
GO:0051174	regulation of phosphorus metabolic process	6.869593099356442e-20	6.869593099356442e-20	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,FLT3,NPM1,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,EP300,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,NCOR1,AXIN2,CDKN2C,EZH2
GO:0042325	regulation of phosphorylation	1.7693605335096334e-19	1.7693605335096334e-19	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,FLT3,NPM1,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,TLR4,LRRK2,KIT,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,AXIN2,CDKN2C,EZH2
GO:0031399	regulation of protein modification process	1.914266150324965e-19	1.914266150324965e-19	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,CTNNB1,FLT3,NPM1,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,EP300,CCND1,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,RPL5,AXIN2,CDKN2C,EZH2
GO:0010557	positive regulation of macromolecule biosynthetic process	2.5602628425709574e-19	2.5602628425709574e-19	+1	TP53,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,SF3B1,TAF1,ATR,VEZF1,CDK12,PTPN11,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,PCBP1
GO:0044238	primary metabolic process	5.065754934727474e-19	5.065754934727474e-19	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,IDH1,TBX3,RPL22,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0043412	macromolecule modification	5.216914529880761e-19	5.216914529880761e-19	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,STK11,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,USP9X,BRCA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,RPL5,SPOP,AXIN2,CDKN2C,EZH2
GO:0051254	positive regulation of RNA metabolic process	6.976732634997304e-19	6.976732634997304e-19	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,SF3B1,TAF1,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,SMAD2,PCBP1
GO:1901360	organic cyclic compound metabolic process	7.12272390098521e-19	7.12272390098521e-19	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,IDH1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0031328	positive regulation of cellular biosynthetic process	1.0304882078248207e-18	1.0304882078248207e-18	+1	TP53,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,SF3B1,TAF1,ATR,VEZF1,CDK12,PTPN11,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,PCBP1
GO:0006366	transcription by RNA polymerase II	1.3111321328593846e-18	1.3111321328593846e-18	+1	TP53,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AR,TSHZ2,SOX9,ATM,WT1,HGF,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,CBFB,SIN3A,VEZF1,CDK12,PHF6,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0009891	positive regulation of biosynthetic process	1.3672107210256642e-18	1.3672107210256642e-18	+1	TP53,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,SF3B1,TAF1,ATR,VEZF1,CDK12,PTPN11,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,PCBP1
GO:0001932	regulation of protein phosphorylation	1.6182961009392794e-18	1.6182961009392794e-18	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,FLT3,NPM1,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,TLR4,LRRK2,KIT,CCND1,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,AXIN2,CDKN2C,EZH2
GO:0036211	protein modification process	1.7102230082060683e-18	1.7102230082060683e-18	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,STK11,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,TET2,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,USP9X,BRCA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,RPL5,SPOP,AXIN2,CDKN2C,EZH2
GO:0010605	negative regulation of macromolecule metabolic process	1.9263478562848184e-18	1.9263478562848184e-18	+1	TP53,PTEN,APC,VHL,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,KDM5C,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,PHF6,PTPN11,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0042127	regulation of cell population proliferation	1.9263478562848184e-18	1.9263478562848184e-18	+1	TP53,PTEN,APC,VHL,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,CTCF,BAP1,NPM1,RUNX1,NRAS,TBX3,STK11,CEBPA,AKT1,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,ERBB4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,BRCA2,FGFR3,TGFBR2,CDKN1A,MAPK8IP1,EGR3,LIFR,CDKN2C,EZH2
GO:0051172	negative regulation of nitrogen compound metabolic process	1.9765668484434165e-18	1.9765668484434165e-18	+1	TP53,PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,KDM5C,ARID5B,ELF3,BRCA1,LRRK2,POLQ,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,PHF6,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0071704	organic substance metabolic process	2.505706428786417e-18	2.505706428786417e-18	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,IDH1,TBX3,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0035556	intracellular signal transduction	4.087917677820348e-18	4.087917677820348e-18	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,FLT3,ARHGAP35,NFE2L2,NRAS,MAP2K4,STK11,AKT1,BRAF,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,PTPN11,MAPK8IP1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,EZH2
GO:0045595	regulation of cell differentiation	4.087917677820348e-18	4.087917677820348e-18	+1	PTEN,APC,VHL,ARID1A,PBRM1,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,TBX3,EPHA3,AKT1,AR,SOX9,HGF,MTOR,TLR4,LRRK2,FOXA1,KIT,PDGFRA,FGFR2,SMAD4,FOXA2,ASXL1,TGFBR2,SOX17,PPP2R1A,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,EZH2
GO:0008283	cell population proliferation	5.4862221730050475e-18	5.4862221730050475e-18	+1	TP53,PTEN,APC,VHL,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,CTCF,BAP1,NPM1,RUNX1,NRAS,TBX3,STK11,CEBPA,AKT1,AR,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,ERBB4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,BRCA2,FGFR3,TGFBR2,CDKN1A,MAPK8IP1,EGR3,MECOM,LIFR,CDKN2C,EZH2
GO:0050793	regulation of developmental process	1.3946345276262364e-17	1.3946345276262364e-17	+1	PTEN,APC,VHL,ARID1A,PBRM1,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,AR,EPPK1,PIK3CG,SOX9,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,FGFR2,SMAD4,FOXA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,EZH2
GO:0051726	regulation of cell cycle	1.667610735464595e-17	1.667610735464595e-17	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,TBX3,STK11,CEBPA,AKT1,SOX9,ATM,CDKN1B,ATRX,BRCA1,FOXA1,CHEK2,SETD2,FGFR2,CCND1,BRCA2,CDKN1A,TAF1,ATR,MECOM,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0044249	cellular biosynthetic process	1.737424321502097e-17	1.737424321502097e-17	+1	TP53,PIK3CA,PTEN,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0006357	regulation of transcription by RNA polymerase II	1.893375163070938e-17	1.893375163070938e-17	+1	TP53,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AR,TSHZ2,SOX9,ATM,WT1,HGF,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,CBFB,SIN3A,VEZF1,CDK12,PHF6,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,EZH2,PCBP1
GO:0008152	metabolic process	1.893375163070938e-17	1.893375163070938e-17	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,IDH1,TBX3,MAP2K4,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0006796	phosphate-containing compound metabolic process	2.8266402100309764e-17	2.8266402100309764e-17	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,IDH1,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,IDH2,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,NCOR1,AXIN2,CDKN2C,EZH2
GO:0048583	regulation of response to stimulus	3.2836349181438037e-17	3.2836349181438037e-17	+1	TP53,PIK3CA,PTEN,APC,VHL,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,ARHGAP35,NFE2L2,NPM1,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:1901576	organic substance biosynthetic process	3.2836349181438037e-17	3.2836349181438037e-17	+1	TP53,PIK3CA,PTEN,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0006793	phosphorus metabolic process	4.133465134697486e-17	4.133465134697486e-17	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,IDH1,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,IDH2,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,NCOR1,AXIN2,CDKN2C,EZH2
GO:0009058	biosynthetic process	5.1784016898072966e-17	5.1784016898072966e-17	+1	TP53,PIK3CA,PTEN,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,KDM6A,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0045944	positive regulation of transcription by RNA polymerase II	6.687593002264393e-17	6.687593002264393e-17	+1	TP53,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AR,SOX9,ATM,WT1,HGF,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,EP300,FGFR2,SMAD4,FOXA2,ASXL1,SOX17,SF3B1,TAF1,VEZF1,CDK12,TBL1XR1,ACVR2A,SMAD2,PCBP1
GO:1902531	regulation of intracellular signal transduction	8.981967175740725e-17	8.981967175740725e-17	+1	TP53,PIK3CA,PTEN,VHL,EGFR,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,ARHGAP35,NFE2L2,STK11,AKT1,BRAF,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,BRCA2,FGFR3,TGFBR2,TAF1,PPP2R1A,ATR,PTPN11,MAPK8IP1,ACVR2A,MECOM,NCOR1,RPL5,EZH2
GO:0007049	cell cycle	9.239751208395018e-17	9.239751208395018e-17	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,TBX3,STK11,CEBPA,AKT1,STAG2,SOX9,ATM,CDKN1B,HGF,ATRX,BRCA1,FOXA1,CHEK2,SETD2,FGFR2,CCND1,BRCA2,CDKN1A,TAF1,PPP2R1A,ATR,SMC1A,ACVR1B,MECOM,SMC3,NCOR1,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0051246	regulation of protein metabolic process	4.0180887273431414e-16	4.0180887273431414e-16	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,CTNNB1,FLT3,KEAP1,NPM1,RUNX1,STK11,CEBPA,AKT1,BRAF,AJUBA,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,CHEK2,KIT,EP300,CCND1,USP9X,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,EIF4A2,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,RPL5,SPOP,AXIN2,CDKN2C,EZH2
GO:0009966	regulation of signal transduction	4.399127278086077e-16	4.399127278086077e-16	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,FLT3,ARHGAP35,NFE2L2,STK11,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0012501	programmed cell death	5.128287851748843e-16	5.128287851748843e-16	+1	TP53,PIK3CA,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,MECOM,ERCC2
GO:0008285	negative regulation of cell population proliferation	5.632272627458236e-16	5.632272627458236e-16	+1	TP53,PTEN,APC,VHL,PBRM1,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,TBX3,STK11,CEBPA,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,ERBB4,FGFR2,BRCA2,CDKN1A,CDKN2C
GO:0008219	cell death	5.717073902330911e-16	5.717073902330911e-16	+1	TP53,PIK3CA,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,MECOM,ERCC2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	9.384558501464891e-16	9.384558501464891e-16	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,ATM,CDKN1B,WT1,KDM5C,ARID5B,ELF3,BRCA1,POLQ,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,CBFB,ATR,SIN3A,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0010558	negative regulation of macromolecule biosynthetic process	1.0024660310921872e-15	1.0024660310921872e-15	+1	TP53,VHL,NAV3,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,KDM5C,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,CBFB,SIN3A,PHF6,PTPN11,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0048856	anatomical structure development	1.0722479647543538e-15	1.0722479647543538e-15	+1	TP53,PIK3CA,PTEN,APC,VHL,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,CDH1,ARHGAP35,CTCF,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,ERCC2,EZH2
GO:0040007	growth	1.097008348673379e-15	1.097008348673379e-15	+1	TP53,PTEN,EGFR,CDKN2A,RB1,NOTCH1,CTNNB1,BAP1,RUNX1,STK11,AKT1,EPPK1,SOX9,CDKN1B,WT1,ERBB4,MTOR,BRCA1,FGFR2,SMAD4,USP9X,FGFR3,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,CDKN2C
GO:0033554	cellular response to stress	1.8088867319311464e-15	1.8088867319311464e-15	+1	TP53,PIK3CA,PTEN,APC,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,NOTCH1,FBXW7,KEAP1,NFE2L2,NPM1,TBX3,MAP2K4,STK11,CEBPA,AKT1,BRAF,AJUBA,ATM,CDKN1B,HGF,MTOR,ATRX,BRCA1,LRRK2,POLQ,CHEK2,SETD2,PDGFRA,EP300,CCND1,BRCA2,NFE2L3,CDKN1A,TAF1,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:0023051	regulation of signaling	1.8088867319311464e-15	1.8088867319311464e-15	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,FLT3,TSHZ3,ARHGAP35,NFE2L2,STK11,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0010646	regulation of cell communication	2.056878964500664e-15	2.056878964500664e-15	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,FLT3,TSHZ3,ARHGAP35,NFE2L2,STK11,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0031327	negative regulation of cellular biosynthetic process	2.236916823460989e-15	2.236916823460989e-15	+1	TP53,VHL,NAV3,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,KDM5C,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,CBFB,SIN3A,PHF6,PTPN11,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0009890	negative regulation of biosynthetic process	2.696058575671127e-15	2.696058575671127e-15	+1	TP53,VHL,NAV3,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,KDM5C,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,CBFB,SIN3A,PHF6,PTPN11,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0006915	apoptotic process	2.879687960585674e-15	2.879687960585674e-15	+1	TP53,PIK3CA,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,ERCC2
GO:0050794	regulation of cellular process	2.8982767959800678e-15	2.8982767959800678e-15	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,SETBP1,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0010564	regulation of cell cycle process	3.0118350653703404e-15	3.0118350653703404e-15	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,FBXW7,CTNNB1,CTCF,NPM1,AKT1,SOX9,ATM,CDKN1B,ATRX,BRCA1,CHEK2,SETD2,CCND1,BRCA2,CDKN1A,TAF1,ATR,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0040008	regulation of growth	4.514783739665481e-15	4.514783739665481e-15	+1	TP53,PTEN,EGFR,CDKN2A,RB1,NOTCH1,BAP1,RUNX1,STK11,AKT1,EPPK1,CDKN1B,WT1,ERBB4,MTOR,BRCA1,FGFR2,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,CDKN2C
GO:0048513	animal organ development	4.86034799232462e-15	4.86034799232462e-15	+1	TP53,PTEN,APC,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,TBX3,CEBPA,EPHA3,AKT1,BRAF,AR,SOX9,CDKN1B,WT1,HGF,ERBB4,MTOR,ARID5B,ELF3,LRRK2,FOXA1,KIT,PDGFRA,FGFR2,SMAD4,FOXA2,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,SIN3A,PTPN11,EGR3,ACVR2A,SMAD2,AXIN2,EZH2
GO:1902806	regulation of cell cycle G1/S phase transition	5.8838879933429304e-15	5.8838879933429304e-15	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,FBXW7,AKT1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A,TAF1,CDKN2C,EZH2
GO:0009628	response to abiotic stimulus	6.091294854194589e-15	6.091294854194589e-15	+1	TP53,PIK3CA,PTEN,VHL,EGFR,NF1,GATA3,NOTCH1,FBXW7,CTNNB1,MAP3K1,NFE2L2,NPM1,MAP2K4,STK11,AKT1,AJUBA,SOX9,ATM,MTOR,TLR4,BRCA1,KIT,EP300,CCND1,SMAD4,BRCA2,CDKN1A,TAF1,ATR,SMC1A
GO:0071495	cellular response to endogenous stimulus	6.773017010287217e-15	6.773017010287217e-15	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,CDH1,STK11,AKT1,AR,SOX9,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,FOXA1,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,TAF1,SIN3A,SMC1A,PTPN11,ACVR1B,EGR3,ACVR2A,NCOR1,SMAD2
GO:0030154	cell differentiation	1.1563574978157433e-14	1.1563574978157433e-14	+1	TP53,PTEN,APC,VHL,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,PRX,ERBB4,MTOR,TLR4,TET2,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,PPP2R1A,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,MECOM,SMAD2,AXIN2,ERCC2,EZH2
GO:0048869	cellular developmental process	1.1563574978157433e-14	1.1563574978157433e-14	+1	TP53,PTEN,APC,VHL,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,PRX,ERBB4,MTOR,TLR4,TET2,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,PPP2R1A,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,MECOM,SMAD2,AXIN2,ERCC2,EZH2
GO:0045892	negative regulation of DNA-templated transcription	1.483995721456941e-14	1.483995721456941e-14	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ELF3,BRCA1,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0007507	heart development	1.5455307027442846e-14	1.5455307027442846e-14	+1	PTEN,APC,EGFR,NF1,GATA3,RB1,NOTCH1,CTNNB1,RUNX1,TBX3,SOX9,CDKN1B,WT1,ERBB4,PDGFRA,FGFR2,SMAD4,TGFBR2,SOX17,CDKN1A,PTPN11,SMAD2,AXIN2
GO:0060485	mesenchyme development	1.7206834432169358e-14	1.7206834432169358e-14	+1	PTEN,APC,GATA3,NOTCH1,CTNNB1,TBX3,EPHA3,SOX9,WT1,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0009719	response to endogenous stimulus	2.0240571119307158e-14	2.0240571119307158e-14	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,CDH1,STK11,AKT1,AR,SOX9,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,FOXA1,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,FGFR3,TGFBR2,TAF1,SIN3A,SMC1A,PTPN11,ACVR1B,EGR3,ACVR2A,NCOR1,SMAD2
GO:1902679	negative regulation of RNA biosynthetic process	2.09656200737758e-14	2.09656200737758e-14	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ELF3,BRCA1,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0072359	circulatory system development	2.7208388186396638e-14	2.7208388186396638e-14	+1	PIK3CA,PTEN,APC,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,TBX3,STK11,AKT1,PIK3CG,SOX9,CDKN1B,WT1,ERBB4,BRCA1,KIT,PDGFRA,FGFR2,SMAD4,TGFBR2,SOX17,CDKN1A,PTPN11,EGR3,SMAD2,AXIN2
GO:0044843	cell cycle G1/S phase transition	3.1598575377531225e-14	3.1598575377531225e-14	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,FBXW7,AKT1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A,TAF1,ACVR1B,CDKN2C,EZH2
GO:0032502	developmental process	3.908628340577278e-14	3.908628340577278e-14	+1	TP53,PIK3CA,PTEN,APC,VHL,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,CDH1,ARHGAP35,CTCF,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,ERCC2,EZH2
GO:0022402	cell cycle process	4.1598501044908386e-14	4.1598501044908386e-14	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,FBXW7,CTNNB1,CTCF,NPM1,STK11,AKT1,STAG2,SOX9,ATM,CDKN1B,ATRX,BRCA1,CHEK2,SETD2,CCND1,BRCA2,CDKN1A,TAF1,PPP2R1A,ATR,SMC1A,ACVR1B,SMC3,NCOR1,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0051253	negative regulation of RNA metabolic process	5.644411364998476e-14	5.644411364998476e-14	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ELF3,BRCA1,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0051716	cellular response to stimulus	5.900344232603297e-14	5.900344232603297e-14	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,ARHGAP35,NFE2L2,NPM1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,ATR,SIN3A,SMC1A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2
GO:1901987	regulation of cell cycle phase transition	8.494473214496968e-14	8.494473214496968e-14	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,FBXW7,NPM1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,TAF1,ATR,ERCC2,CDKN2C,EZH2
GO:0009967	positive regulation of signal transduction	1.1916730017366488e-13	1.1916730017366488e-13	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,ASXL1,TGFBR2,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,EZH2
GO:0051338	regulation of transferase activity	1.1916730017366488e-13	1.1916730017366488e-13	+1	TP53,PTEN,APC,EGFR,NF1,CDKN2A,RB1,FBXW7,FLT3,NPM1,STK11,CEBPA,AKT1,PIK3CG,CDKN1B,TLR4,LRRK2,CCND1,FOXA2,TGFBR2,CDKN1A,EIF4A2,CDK12,MAPK8IP1,RPL5,CDKN2C,EZH2
GO:0048762	mesenchymal cell differentiation	1.5156724495707752e-13	1.5156724495707752e-13	+1	PTEN,GATA3,NOTCH1,CTNNB1,TBX3,EPHA3,SOX9,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0001837	epithelial to mesenchymal transition	1.7454524835292442e-13	1.7454524835292442e-13	+1	PTEN,GATA3,NOTCH1,CTNNB1,TBX3,EPHA3,SOX9,HGF,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0071900	regulation of protein serine/threonine kinase activity	2.4170455923980487e-13	2.4170455923980487e-13	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,FLT3,CEBPA,AKT1,PIK3CG,CDKN1B,TLR4,LRRK2,CCND1,CDKN1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0007275	multicellular organism development	2.8224044644874276e-13	2.8224044644874276e-13	+1	TP53,PIK3CA,PTEN,APC,ARID1A,PBRM1,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,AR,PIK3CG,SOX9,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,SMAD2,AXIN2,ERCC2
GO:0018193	peptidyl-amino acid modification	3.2827934614023316e-13	3.2827934614023316e-13	+1	TP53,PTEN,EGFR,CDKN2A,FBXW7,CTNNB1,FLT3,STK11,EPHA3,AKT1,BRAF,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,SETD2,PDGFRA,EP300,FGFR2,FGFR3,TAF1,PPP2R1A,ATR,PTPN11,ACVR1B,NSD1
GO:0065009	regulation of molecular function	3.841230172034327e-13	3.841230172034327e-13	+1	TP53,PTEN,APC,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,FLT3,KEAP1,NPM1,STK11,CEBPA,EPHA3,AKT1,AR,PIK3CG,CDKN1B,MTOR,TLR4,ARID5B,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,FOXA2,USP9X,FGFR3,TGFBR2,CDKN1A,TAF1,EIF4A2,CDK12,MAPK8IP1,NSD1,RPL5,SMAD2,CDKN2C,EZH2
GO:0010647	positive regulation of cell communication	4.331206740576382e-13	4.331206740576382e-13	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,TSHZ3,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,ASXL1,TGFBR2,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,EZH2
GO:0023056	positive regulation of signaling	4.609684249078603e-13	4.609684249078603e-13	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,TSHZ3,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,ASXL1,TGFBR2,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,EZH2
GO:0043549	regulation of kinase activity	5.319337366941015e-13	5.319337366941015e-13	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,FBXW7,FLT3,NPM1,STK11,CEBPA,AKT1,PIK3CG,CDKN1B,TLR4,LRRK2,CCND1,FOXA2,TGFBR2,CDKN1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0104004	cellular response to environmental stimulus	5.958971483027827e-13	5.958971483027827e-13	+1	TP53,PIK3CA,PTEN,GATA3,FBXW7,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,MTOR,TLR4,BRCA1,EP300,BRCA2,CDKN1A,TAF1,ATR
GO:0141124	intracellular signaling cassette	5.958971483027827e-13	5.958971483027827e-13	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,FLT3,ARHGAP35,NRAS,MAP2K4,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,PPP2R1A,PTPN11,MAPK8IP1,ACVR2A,MECOM,NCOR1,SMAD2,EZH2
GO:0071214	cellular response to abiotic stimulus	5.958971483027827e-13	5.958971483027827e-13	+1	TP53,PIK3CA,PTEN,GATA3,FBXW7,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,MTOR,TLR4,BRCA1,EP300,BRCA2,CDKN1A,TAF1,ATR
GO:0044770	cell cycle phase transition	7.557288107527761e-13	7.557288107527761e-13	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,FBXW7,NPM1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,TAF1,ATR,ACVR1B,ERCC2,CDKN2C,EZH2
GO:0051247	positive regulation of protein metabolic process	8.266567117190974e-13	8.266567117190974e-13	+1	TP53,PTEN,APC,KRAS,EGFR,CDKN2A,FBXW7,CTNNB1,FLT3,KEAP1,NPM1,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,CCND1,FGFR3,TGFBR2,CDKN1A,TAF1,PTPN11,ACVR2A,RPL5,AXIN2,EZH2
GO:0045859	regulation of protein kinase activity	1.0177365170017397e-12	1.0177365170017397e-12	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,FBXW7,FLT3,NPM1,STK11,CEBPA,AKT1,PIK3CG,CDKN1B,TLR4,LRRK2,CCND1,TGFBR2,CDKN1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0006950	response to stress	1.5826155960953029e-12	1.5826155960953029e-12	+1	TP53,PIK3CA,PTEN,APC,VHL,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,KEAP1,ARHGAP35,NFE2L2,NPM1,TBX3,MAP2K4,STK11,CEBPA,AKT1,BRAF,AJUBA,EPPK1,PIK3CG,ATM,CDKN1B,HGF,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,KIT,SETD2,PDGFRA,EP300,CCND1,SMAD4,FOXA2,BRCA2,NFE2L3,CDKN1A,TAF1,ATR,SIN3A,VEZF1,SMC1A,PTPN11,AXIN2,RAD21,ERCC2
GO:0051239	regulation of multicellular organismal process	1.7238210617380053e-12	1.7238210617380053e-12	+1	PIK3CA,PTEN,APC,ARID1A,PBRM1,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,TSHZ3,RUNX1,STK11,CEBPA,AKT1,EPPK1,PIK3CG,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,BRCA2,TGFBR2,SOX17,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,MAPK8IP1,ACVR2A,SMAD2,AXIN2,EZH2
GO:1902533	positive regulation of intracellular signal transduction	1.7884183881685046e-12	1.7884183881685046e-12	+1	TP53,PIK3CA,EGFR,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,ATR,PTPN11,MAPK8IP1,ACVR2A,EZH2
GO:2000045	regulation of G1/S transition of mitotic cell cycle	2.1695238708610278e-12	2.1695238708610278e-12	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A,CDKN2C
GO:0000165	MAPK cascade	2.1705386424784214e-12	2.1705386424784214e-12	+1	KRAS,EGFR,NF1,NOTCH1,FBXW7,FLT3,NRAS,MAP2K4,BRAF,PIK3CG,SOX9,HGF,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PPP2R1A,PTPN11,MAPK8IP1,MECOM,NCOR1,EZH2
GO:0016049	cell growth	2.5345581127811e-12	2.5345581127811e-12	+1	TP53,EGFR,CDKN2A,RB1,CTNNB1,BAP1,STK11,AKT1,SOX9,CDKN1B,WT1,MTOR,BRCA1,SMAD4,USP9X,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,CDKN2C
GO:0051128	regulation of cellular component organization	2.559898011786612e-12	2.559898011786612e-12	+1	TP53,PIK3CA,PTEN,APC,ARID1A,PBRM1,NAV3,EGFR,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,STK11,EPHA3,AKT1,AR,AJUBA,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,PDGFRA,EP300,SMAD4,SOX17,CDKN1A,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,AXIN2,RAD21,CDKN2C
GO:0010717	regulation of epithelial to mesenchymal transition	2.7499984426618495e-12	2.7499984426618495e-12	+1	PTEN,GATA3,NOTCH1,CTNNB1,EPHA3,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0048732	gland development	3.190776155550785e-12	3.190776155550785e-12	+1	NF1,GATA3,FBXW7,ARHGAP35,TBX3,CEBPA,AKT1,SOX9,WT1,HGF,ERBB4,ARID5B,ELF3,FGFR2,BRCA2
GO:0031401	positive regulation of protein modification process	4.711489976999482e-12	4.711489976999482e-12	+1	TP53,PTEN,KRAS,EGFR,CDKN2A,FBXW7,FLT3,STK11,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,CCND1,FGFR3,TGFBR2,CDKN1A,PTPN11,ACVR2A,AXIN2,EZH2
GO:0046777	protein autophosphorylation	6.050590171203939e-12	6.050590171203939e-12	+1	EGFR,FLT3,STK11,AKT1,ATM,ERBB4,MTOR,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,TAF1,ATR,CDK12,ACVR1B
GO:0009888	tissue development	7.094732051975181e-12	7.094732051975181e-12	+1	TP53,PTEN,APC,NF1,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,EPPK1,SOX9,WT1,HGF,ERBB4,MTOR,ARID5B,FOXA1,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,BRCA2,FGFR3,TGFBR2,SOX17,VEZF1,PTPN11,ACVR2A,SMAD2,AXIN2,ERCC2,EZH2
GO:0000082	G1/S transition of mitotic cell cycle	9.131790691171837e-12	9.131790691171837e-12	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A,ACVR1B,CDKN2C
GO:0042327	positive regulation of phosphorylation	1.1533286701407923e-11	1.1533286701407923e-11	+1	TP53,KRAS,EGFR,FBXW7,FLT3,STK11,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,TLR4,LRRK2,KIT,CCND1,FGFR3,TGFBR2,CDKN1A,PTPN11,ACVR2A,AXIN2,EZH2
GO:0007165	signal transduction	1.2695166161167063e-11	1.2695166161167063e-11	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,ARHGAP35,NFE2L2,NPM1,NRAS,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0048731	system development	1.554819749711145e-11	1.554819749711145e-11	+1	TP53,PIK3CA,PTEN,APC,PBRM1,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,AR,PIK3CG,SOX9,CDKN1B,WT1,HGF,PRX,ERBB4,ARID5B,BRCA1,LRRK2,POLQ,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,TGFBR2,SOX17,CDKN1A,TAF1,SIN3A,PTPN11,ACVR1B,EGR3,SMAD2,AXIN2,ERCC2
GO:0050790	regulation of catalytic activity	1.7365820760685215e-11	1.7365820760685215e-11	+1	TP53,PTEN,APC,EGFR,NF1,CDKN2A,RB1,NOTCH1,FBXW7,FLT3,NPM1,STK11,CEBPA,EPHA3,AKT1,PIK3CG,CDKN1B,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,EIF4A2,CDK12,MAPK8IP1,RPL5,CDKN2C,EZH2
GO:0048584	positive regulation of response to stimulus	1.7365820760685215e-11	1.7365820760685215e-11	+1	TP53,PIK3CA,PTEN,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,ASXL1,TGFBR2,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,EZH2
GO:0023052	signaling	1.8079068138090306e-11	1.8079068138090306e-11	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,ARHGAP35,NFE2L2,NPM1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0010562	positive regulation of phosphorus metabolic process	1.9704892855600012e-11	1.9704892855600012e-11	+1	TP53,KRAS,EGFR,FBXW7,FLT3,STK11,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,CCND1,FGFR3,TGFBR2,CDKN1A,PTPN11,ACVR2A,AXIN2,EZH2
GO:0045937	positive regulation of phosphate metabolic process	1.9704892855600012e-11	1.9704892855600012e-11	+1	TP53,KRAS,EGFR,FBXW7,FLT3,STK11,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,CCND1,FGFR3,TGFBR2,CDKN1A,PTPN11,ACVR2A,AXIN2,EZH2
GO:0048468	cell development	2.2997163661134136e-11	2.2997163661134136e-11	+1	TP53,PTEN,ARID1A,PBRM1,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,ARHGAP35,CTCF,RUNX1,TBX3,CEBPA,EPHA3,AKT1,SOX9,ATM,WT1,PRX,ERBB4,MTOR,TLR4,TET2,LRRK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A,MECOM,AXIN2
GO:0019538	protein metabolic process	2.4212384892934336e-11	2.4212384892934336e-11	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,RUNX1,RPL22,STK11,CEBPA,EPHA3,AKT1,BRAF,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,TET2,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,USP9X,BRCA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,EIF4A2,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,RPL5,SPOP,AXIN2,CDKN2C,EZH2
GO:0043067	regulation of programmed cell death	3.043737220043886e-11	3.043737220043886e-11	+1	TP53,PIK3CA,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,FGFR2,EGR3,MECOM
GO:0007154	cell communication	3.260888746788921e-11	3.260888746788921e-11	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,ARHGAP35,NFE2L2,NPM1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0007167	enzyme-linked receptor protein signaling pathway	3.34764141667633e-11	3.34764141667633e-11	+1	PIK3CA,APC,EGFR,PIK3R1,GATA3,NOTCH1,FLT3,STK11,EPHA3,AKT1,BRAF,SOX9,HGF,ERBB4,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,SIN3A,PTPN11,ACVR1B,ACVR2A,LIFR,SMAD2
GO:0051052	regulation of DNA metabolic process	3.405246141526513e-11	3.405246141526513e-11	+1	TP53,ARID1A,PBRM1,EGFR,CDKN2A,CTNNB1,NPM1,AKT1,ATM,WT1,HGF,ATRX,BRCA1,POLQ,SETD2,USP9X,CDKN1A,PPP2R1A,ATR,SMC3,AXIN2,ERCC2
GO:0001934	positive regulation of protein phosphorylation	3.4845380890594285e-11	3.4845380890594285e-11	+1	TP53,KRAS,EGFR,FBXW7,FLT3,STK11,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,TLR4,LRRK2,KIT,CCND1,FGFR3,TGFBR2,CDKN1A,PTPN11,ACVR2A,AXIN2,EZH2
GO:0070887	cellular response to chemical stimulus	3.5511997108824274e-11	3.5511997108824274e-11	+1	TP53,PIK3CA,APC,VHL,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,FLT3,KEAP1,CDH1,NFE2L2,NPM1,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,SMAD4,FOXA2,TAF1,SIN3A,PTPN11,EGR3,LIFR,NCOR1
GO:0010033	response to organic substance	3.671019476070111e-11	3.671019476070111e-11	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,FLT3,CDH1,NFE2L2,NPM1,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,SETD2,EP300,CCND1,SMAD4,FOXA2,ASXL1,TGFBR2,TAF1,PPP2R1A,SIN3A,PTPN11,LIFR,NCOR1,SMAD2
GO:0009653	anatomical structure morphogenesis	4.801001158792495e-11	4.801001158792495e-11	+1	PTEN,APC,VHL,NF1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,BRAF,PIK3CG,SOX9,WT1,HGF,ERBB4,MTOR,ELF3,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,SIN3A,PTPN11,EGR3,SMAD2,AXIN2
GO:0045926	negative regulation of growth	5.3122521740226e-11	5.3122521740226e-11	+1	TP53,PTEN,CDKN2A,RB1,STK11,CDKN1B,WT1,BRCA1,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0042981	regulation of apoptotic process	6.071469647121253e-11	6.071469647121253e-11	+1	TP53,PIK3CA,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,FGFR2,EGR3
GO:0072331	signal transduction by p53 class mediator	7.112977974845841e-11	7.112977974845841e-11	+1	TP53,CDKN2A,STK11,AKT1,ATM,CDKN1B,MTOR,ATRX,CHEK2,EP300,CDKN1A,TAF1,ATR,RPL5
GO:0043069	negative regulation of programmed cell death	8.615296679863475e-11	8.615296679863475e-11	+1	TP53,PIK3CA,VHL,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,WT1,HGF,ERBB4,MTOR,BRCA1,LRRK2,FGFR2,EGR3,MECOM
GO:0007062	sister chromatid cohesion	8.829499913591957e-11	8.829499913591957e-11	+1	RB1,FBXW7,CTNNB1,CTCF,STAG2,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0009887	animal organ morphogenesis	1.199313361264857e-10	1.199313361264857e-10	+1	PTEN,APC,NF1,GATA3,NOTCH1,FBXW7,CTNNB1,TBX3,BRAF,SOX9,WT1,HGF,ELF3,LRRK2,PDGFRA,FGFR2,SMAD4,FGFR3,ASXL1,TGFBR2,SOX17,SMAD2,AXIN2
GO:0042221	response to chemical	1.794908499851781e-10	1.794908499851781e-10	+1	TP53,PIK3CA,APC,VHL,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,FLT3,KEAP1,CDH1,NFE2L2,NPM1,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,CCND1,SMAD4,FOXA2,ASXL1,TGFBR2,TAF1,PPP2R1A,SIN3A,PTPN11,EGR3,LIFR,NCOR1,SMAD2
GO:0051348	negative regulation of transferase activity	1.8013908861322107e-10	1.8013908861322107e-10	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,EIF4A2,MAPK8IP1,RPL5
GO:0071363	cellular response to growth factor stimulus	1.8604859024911484e-10	1.8604859024911484e-10	+1	PIK3CA,EGFR,GATA3,NOTCH1,CTNNB1,STK11,AKT1,SOX9,HGF,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,SIN3A,PTPN11,ACVR1B,EGR3,ACVR2A,SMAD2
GO:0000278	mitotic cell cycle	2.0483150472004756e-10	2.0483150472004756e-10	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,CTNNB1,AKT1,STAG2,ATM,CDKN1B,HGF,BRCA1,FOXA1,CHEK2,SETD2,CCND1,BRCA2,CDKN1A,SMC1A,ACVR1B,SMC3,RAD21,ERCC2,CDKN2C
GO:0006974	DNA damage response	2.2223886171493337e-10	2.2223886171493337e-10	+1	TP53,APC,ARID1A,PBRM1,EGFR,CDKN2A,FBXW7,NPM1,STK11,ATM,CDKN1B,MTOR,ATRX,BRCA1,POLQ,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,TAF1,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:0051093	negative regulation of developmental process	2.3537500972116323e-10	2.3537500972116323e-10	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,TBX3,SOX9,CDKN1B,WT1,TLR4,FOXA1,SMAD4,FOXA2,FGFR3,ASXL1,CDKN1A,CBFB,SIN3A,PTPN11
GO:0001558	regulation of cell growth	2.464842046816731e-10	2.464842046816731e-10	+1	TP53,EGFR,CDKN2A,RB1,BAP1,STK11,AKT1,CDKN1B,WT1,MTOR,BRCA1,SMAD4,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,CDKN2C
GO:0006259	DNA metabolic process	2.484492978301247e-10	2.484492978301247e-10	+1	TP53,ARID1A,PBRM1,EGFR,CDKN2A,CTNNB1,DNMT3A,NPM1,AKT1,ATM,WT1,HGF,TET2,ATRX,BRCA1,POLQ,CHEK2,SETD2,USP9X,BRCA2,CDKN1A,PPP2R1A,ATR,SMC1A,SMC3,AXIN2,RAD21,ERCC2
GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	2.5412841391394096e-10	2.5412841391394096e-10	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,MTOR,KIT,PDGFRA,FGFR3,PPP2R1A
GO:0009968	negative regulation of signal transduction	2.570881454944786e-10	2.570881454944786e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,SOX17,PPP2R1A,SIN3A,MAPK8IP1,MECOM,NCOR1,AXIN2,EZH2
GO:0050896	response to stimulus	2.5775269752675974e-10	2.5775269752675974e-10	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,ARHGAP35,NFE2L2,NPM1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,ATR,SIN3A,VEZF1,SMC1A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2
GO:0043066	negative regulation of apoptotic process	2.7889743921546014e-10	2.7889743921546014e-10	+1	TP53,PIK3CA,VHL,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,WT1,HGF,ERBB4,MTOR,BRCA1,LRRK2,FGFR2,EGR3
GO:0070848	response to growth factor	3.381554939857949e-10	3.381554939857949e-10	+1	PIK3CA,EGFR,GATA3,NOTCH1,CTNNB1,STK11,AKT1,SOX9,HGF,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,SIN3A,PTPN11,ACVR1B,EGR3,ACVR2A,SMAD2
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	3.577093154235665e-10	3.577093154235665e-10	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:1901990	regulation of mitotic cell cycle phase transition	4.705093179031026e-10	4.705093179031026e-10	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ERCC2,CDKN2C
GO:0043408	regulation of MAPK cascade	5.010115009141925e-10	5.010115009141925e-10	+1	EGFR,NF1,NOTCH1,FBXW7,FLT3,BRAF,PIK3CG,HGF,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PPP2R1A,PTPN11,MAPK8IP1,MECOM,NCOR1,EZH2
GO:1904029	regulation of cyclin-dependent protein kinase activity	6.821588764269926e-10	6.821588764269926e-10	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:0030308	negative regulation of cell growth	7.136042350673352e-10	7.136042350673352e-10	+1	TP53,CDKN2A,RB1,STK11,CDKN1B,WT1,BRCA1,SMAD4,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0010648	negative regulation of cell communication	7.201175397748101e-10	7.201175397748101e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,SOX17,PPP2R1A,SIN3A,MAPK8IP1,MECOM,NCOR1,AXIN2,EZH2
GO:1903047	mitotic cell cycle process	7.58774757292712e-10	7.58774757292712e-10	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,AKT1,STAG2,ATM,CDKN1B,BRCA1,CHEK2,SETD2,CCND1,BRCA2,CDKN1A,SMC1A,ACVR1B,SMC3,RAD21,ERCC2,CDKN2C
GO:0045786	negative regulation of cell cycle	7.711433689189262e-10	7.711433689189262e-10	+1	TP53,PTEN,APC,CDKN2A,GATA3,RB1,CTNNB1,NPM1,CEBPA,ATM,CDKN1B,ATRX,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:0023057	negative regulation of signaling	7.944193694491152e-10	7.944193694491152e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,SOX17,PPP2R1A,SIN3A,MAPK8IP1,MECOM,NCOR1,AXIN2,EZH2
GO:0045936	negative regulation of phosphate metabolic process	8.187304528909705e-10	8.187304528909705e-10	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,LRRK2,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,NCOR1,CDKN2C
GO:0080135	regulation of cellular response to stress	8.187304528909705e-10	8.187304528909705e-10	+1	VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,FBXW7,NFE2L2,NPM1,AJUBA,ATM,MTOR,BRCA1,LRRK2,POLQ,SETD2,EP300,BRCA2,ATR,AXIN2
GO:0048585	negative regulation of response to stimulus	8.312005527707783e-10	8.312005527707783e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,AKT1,AR,AJUBA,EPPK1,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,POLQ,PDGFRA,SMAD4,ASXL1,SOX17,PPP2R1A,SIN3A,MAPK8IP1,MECOM,NCOR1,AXIN2,EZH2
GO:0010563	negative regulation of phosphorus metabolic process	8.512833483743587e-10	8.512833483743587e-10	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,LRRK2,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,NCOR1,CDKN2C
GO:1901564	organonitrogen compound metabolic process	9.215854592029254e-10	9.215854592029254e-10	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,RUNX1,IDH1,RPL22,STK11,CEBPA,EPHA3,AKT1,BRAF,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,TET2,BRCA1,LRRK2,IDH2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,USP9X,BRCA2,FGFR3,TGFBR2,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,EIF4A2,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,NCOR1,RPL5,SPOP,AXIN2,CDKN2C,EZH2
GO:0009314	response to radiation	9.868612840126922e-10	9.868612840126922e-10	+1	TP53,EGFR,NF1,GATA3,FBXW7,NPM1,STK11,AKT1,ATM,BRCA1,EP300,CCND1,BRCA2,CDKN1A,TAF1,ATR,SMC1A
GO:0000122	negative regulation of transcription by RNA polymerase II	1.0173417787099306e-9	1.0173417787099306e-9	+1	TP53,GATA3,RB1,NOTCH1,DNMT3A,CTCF,RUNX1,TBX3,CEBPA,AR,SOX9,WT1,ARID5B,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,NCOR1,EZH2
GO:0045597	positive regulation of cell differentiation	1.2243800530974304e-9	1.2243800530974304e-9	+1	VHL,ARID1A,PBRM1,GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,AR,SOX9,HGF,MTOR,KIT,SMAD4,TGFBR2,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,EZH2
GO:0080134	regulation of response to stress	1.24299656605551e-9	1.24299656605551e-9	+1	PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,FBXW7,NFE2L2,NPM1,CEBPA,AKT1,AJUBA,EPPK1,ATM,MTOR,TLR4,BRCA1,LRRK2,POLQ,SETD2,PDGFRA,EP300,FOXA2,BRCA2,ATR,SIN3A,PTPN11,AXIN2
GO:0071310	cellular response to organic substance	1.4062151381764022e-9	1.4062151381764022e-9	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,FLT3,CDH1,NFE2L2,NPM1,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,EP300,SMAD4,FOXA2,TAF1,SIN3A,PTPN11,LIFR,NCOR1
GO:0007166	cell surface receptor signaling pathway	1.8359895809237916e-9	1.8359895809237916e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,SOX9,HGF,ERBB4,TLR4,BRCA1,LRRK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,SOX17,PPP2R1A,SIN3A,PTPN11,ACVR1B,TBL1XR1,ACVR2A,LIFR,SMAD2,AXIN2
GO:0010628	positive regulation of gene expression	1.8681343699472094e-9	1.8681343699472094e-9	+1	TP53,KRAS,ARID1A,PIK3R1,CDKN2A,GATA3,NOTCH1,CTCF,NFE2L2,NPM1,RUNX1,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,WT1,MTOR,TLR4,BRCA1,KIT,SETD2,EP300,SMAD4,PTPN11,RPL5,AXIN2
GO:0051241	negative regulation of multicellular organismal process	2.177525654367318e-9	2.177525654367318e-9	+1	PTEN,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,STK11,EPPK1,PIK3CG,SOX9,ATM,WT1,TLR4,FOXA1,PDGFRA,SMAD4,FOXA2,BRCA2,CBFB,SIN3A,PTPN11
GO:0051094	positive regulation of developmental process	2.661863310637181e-9	2.661863310637181e-9	+1	VHL,ARID1A,PBRM1,GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,AR,SOX9,WT1,HGF,ERBB4,MTOR,BRCA1,KIT,FGFR2,SMAD4,FOXA2,TGFBR2,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,EZH2
GO:0044772	mitotic cell cycle phase transition	2.9793148806177177e-9	2.9793148806177177e-9	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ACVR1B,ERCC2,CDKN2C
GO:0007346	regulation of mitotic cell cycle	3.829659458393346e-9	3.829659458393346e-9	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,CTNNB1,AKT1,ATM,CDKN1B,BRCA1,FOXA1,CHEK2,CCND1,CDKN1A,ERCC2,CDKN2C
GO:0016043	cellular component organization	3.855680881280042e-9	3.855680881280042e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,CDH1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,STK11,KDM6A,EPHA3,AKT1,STAG2,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,USP9X,BRCA2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,ATR,SIN3A,SMC1A,PTPN11,ACVR1B,MECOM,SMC3,NCOR1,RPL5,AXIN2,RAD21,CDKN2C,EZH2
GO:0032501	multicellular organismal process	4.0741301171146935e-9	4.0741301171146935e-9	+1	TP53,PIK3CA,PTEN,APC,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,TSHZ3,CDH1,ARHGAP35,CTCF,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,AR,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,MAPK8IP1,EGR3,ACVR2A,NCOR1,SMAD2,AXIN2,ERCC2,EZH2
GO:0044093	positive regulation of molecular function	4.606186410975244e-9	4.606186410975244e-9	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,FBXW7,FLT3,NPM1,STK11,AKT1,AR,PIK3CG,MTOR,TLR4,ARID5B,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,USP9X,FGFR3,TGFBR2,CDKN1A,TAF1,EZH2
GO:0042326	negative regulation of phosphorylation	4.677569976818122e-9	4.677569976818122e-9	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,LRRK2,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,CDKN2C
GO:1901700	response to oxygen-containing compound	6.71607536931241e-9	6.71607536931241e-9	+1	TP53,PIK3CA,APC,EGFR,PIK3R1,CTNNB1,CDH1,NFE2L2,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,FOXA1,PDGFRA,EP300,FOXA2,ASXL1,TGFBR2,TAF1,PTPN11,SMAD2
GO:0006338	chromatin remodeling	6.930967085835588e-9	6.930967085835588e-9	+1	TP53,ARID1A,PBRM1,RB1,DNMT3A,CTCF,NPM1,KDM6A,SOX9,KDM5C,ATRX,BRCA1,FOXA1,SETD2,EP300,SF3B1,SIN3A,MECOM,EZH2
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	8.777451255805713e-9	8.777451255805713e-9	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
GO:0009894	regulation of catabolic process	8.871981988318677e-9	8.871981988318677e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,CDKN2A,FBXW7,KEAP1,NPM1,STK11,CEBPA,AKT1,ATM,CDKN1B,HGF,MTOR,LRRK2,CHEK2,SETD2,EP300,USP9X,TAF1,NCOR1,RPL5,AXIN2
GO:0051240	positive regulation of multicellular organismal process	1.2339132294519567e-8	1.2339132294519567e-8	+1	PIK3CA,APC,ARID1A,PBRM1,GATA3,NOTCH1,CTNNB1,RUNX1,CEBPA,AKT1,PIK3CG,SOX9,WT1,ERBB4,MTOR,TLR4,BRCA1,KIT,SETD2,FGFR2,SMAD4,FOXA2,TGFBR2,CBFB,SIN3A,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,EZH2
GO:0071478	cellular response to radiation	1.273065731447458e-8	1.273065731447458e-8	+1	TP53,GATA3,FBXW7,NPM1,STK11,ATM,BRCA1,EP300,BRCA2,CDKN1A,TAF1,ATR
GO:0030097	hemopoiesis	1.273697448127903e-8	1.273697448127903e-8	+1	TP53,ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,TET2,KIT,FGFR2,TGFBR2,CBFB,ACVR1B,ACVR2A,MECOM
GO:0003170	heart valve development	1.5438660384950982e-8	1.5438660384950982e-8	+1	APC,GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2,SMAD2,AXIN2
GO:1901796	regulation of signal transduction by p53 class mediator	1.5887742213800844e-8	1.5887742213800844e-8	+1	CDKN2A,STK11,AKT1,ATM,MTOR,CHEK2,EP300,TAF1,ATR,RPL5
GO:1902807	negative regulation of cell cycle G1/S phase transition	1.761026972609866e-8	1.761026972609866e-8	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
GO:0071840	cellular component organization or biogenesis	1.8917738765876775e-8	1.8917738765876775e-8	+1	TP53,PIK3CA,PTEN,APC,VHL,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,CDH1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,STK11,KDM6A,EPHA3,AKT1,STAG2,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,USP9X,BRCA2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,ATR,SIN3A,SMC1A,PTPN11,ACVR1B,MECOM,SMC3,NCOR1,RPL5,AXIN2,RAD21,CDKN2C,EZH2
GO:0043410	positive regulation of MAPK cascade	2.4167294505541538e-8	2.4167294505541538e-8	+1	EGFR,NOTCH1,FBXW7,FLT3,BRAF,PIK3CG,HGF,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,FGFR3,PTPN11,MAPK8IP1,EZH2
GO:0033673	negative regulation of kinase activity	2.437974828361478e-8	2.437974828361478e-8	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,MAPK8IP1
GO:0030879	mammary gland development	2.9014480719395563e-8	2.9014480719395563e-8	+1	GATA3,ARHGAP35,TBX3,AKT1,ERBB4,ELF3,FGFR2,BRCA2
GO:0048729	tissue morphogenesis	2.9692922987413112e-8	2.9692922987413112e-8	+1	PTEN,APC,GATA3,NOTCH1,CTNNB1,ARHGAP35,TBX3,SOX9,WT1,HGF,MTOR,FGFR2,SMAD4,TGFBR2,SOX17,SMAD2
GO:0043086	negative regulation of catalytic activity	3.277168700868005e-8	3.277168700868005e-8	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NOTCH1,NPM1,CEBPA,AKT1,CDKN1B,LRRK2,FOXA2,CDKN1A,EIF4A2,MAPK8IP1,RPL5
GO:0010718	positive regulation of epithelial to mesenchymal transition	3.402060797810515e-8	3.402060797810515e-8	+1	NOTCH1,CTNNB1,MTOR,SMAD4,TGFBR2,SMAD2,AXIN2,EZH2
GO:0045596	negative regulation of cell differentiation	3.458695674840725e-8	3.458695674840725e-8	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,RUNX1,TBX3,SOX9,TLR4,FOXA1,SMAD4,FOXA2,ASXL1,CBFB,PTPN11
GO:0009411	response to UV	3.7218025413059926e-8	3.7218025413059926e-8	+1	TP53,EGFR,FBXW7,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR
GO:0033043	regulation of organelle organization	4.069492388467518e-8	4.069492388467518e-8	+1	TP53,PIK3CA,APC,ARID1A,PBRM1,NAV3,PIK3R1,RB1,FBXW7,CTNNB1,ARHGAP35,CTCF,NPM1,EPHA3,AKT1,ATM,HGF,MTOR,ATRX,BRCA1,LRRK2,PDGFRA,EP300,SMAD4,ATR,AXIN2,RAD21
GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	4.128992193032537e-8	4.128992193032537e-8	+1	PIK3CA,PTEN,EGFR,GATA3,FLT3,PIK3CG,SOX9,HGF,MTOR,KIT,PDGFRA,FGFR3,PPP2R1A
GO:1901701	cellular response to oxygen-containing compound	4.128992193032537e-8	4.128992193032537e-8	+1	TP53,PIK3CA,APC,EGFR,PIK3R1,CTNNB1,CDH1,NFE2L2,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,PDGFRA,EP300,FOXA2,TAF1,PTPN11
GO:0031400	negative regulation of protein modification process	4.419456377466977e-8	4.419456377466977e-8	+1	PTEN,APC,NF1,CDKN2A,RB1,CTNNB1,NPM1,CEBPA,AKT1,CDKN1B,LRRK2,CDKN1A,TAF1,PPP2R1A,MAPK8IP1,RPL5
GO:0030155	regulation of cell adhesion	4.9428695081598936e-8	4.9428695081598936e-8	+1	PIK3CA,PTEN,ARID1A,PBRM1,NF1,CDKN2A,GATA3,NOTCH1,CDH1,RUNX1,EPHA3,AKT1,PIK3CG,ATM,MTOR,FOXA1,FOXA2,TGFBR2,PPP2R1A,CBFB,PTPN11
GO:0008284	positive regulation of cell population proliferation	6.1667163108893e-8	6.1667163108893e-8	+1	PTEN,EGFR,PIK3R1,NOTCH1,CTNNB1,FLT3,NPM1,NRAS,TBX3,AKT1,AR,SOX9,ERBB4,PDGFRA,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,EGR3,LIFR,EZH2
GO:0006325	chromatin organization	6.265824640540671e-8	6.265824640540671e-8	+1	TP53,ARID1A,PBRM1,RB1,DNMT3A,CTCF,NPM1,KDM6A,SOX9,KDM5C,ATRX,BRCA1,FOXA1,SETD2,EP300,SF3B1,SIN3A,MECOM,EZH2
GO:1901699	cellular response to nitrogen compound	6.310049930253007e-8	6.310049930253007e-8	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,NPM1,AKT1,SOX9,WT1,MTOR,TLR4,ATRX,BRCA1,LRRK2,EP300,TAF1,PTPN11
GO:0003179	heart valve morphogenesis	7.270644038085145e-8	7.270644038085145e-8	+1	GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2,SMAD2,AXIN2
GO:0018108	peptidyl-tyrosine phosphorylation	7.607744620414435e-8	7.607744620414435e-8	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
GO:0018212	peptidyl-tyrosine modification	8.477877626986938e-8	8.477877626986938e-8	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
GO:0090398	cellular senescence	9.27122700343957e-8	9.27122700343957e-8	+1	TP53,PTEN,CDKN2A,NPM1,TBX3,MAP2K4,ATM,CDKN1B,CDKN1A
GO:0097190	apoptotic signaling pathway	9.310454640189006e-8	9.310454640189006e-8	+1	TP53,RB1,FBXW7,NFE2L2,STK11,AKT1,AR,ATM,HGF,TLR4,BRCA1,LRRK2,CHEK2,EP300,SMAD4,FGFR3,CDKN1A,ACVR1B
GO:1904030	negative regulation of cyclin-dependent protein kinase activity	9.601668963223077e-8	9.601668963223077e-8	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B,CDKN1A
GO:0010948	negative regulation of cell cycle process	1.0098364714262165e-7	1.0098364714262165e-7	+1	TP53,PTEN,APC,RB1,NPM1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:0071901	negative regulation of protein serine/threonine kinase activity	1.0200916672160196e-7	1.0200916672160196e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,CEBPA,AKT1,CDKN1B,MAPK8IP1
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	1.1134743797641274e-7	1.1134743797641274e-7	+1	PTEN,CDKN2A,FBXW7,KEAP1,CEBPA,AKT1,LRRK2,USP9X,TAF1,RPL5,AXIN2
GO:0003180	aortic valve morphogenesis	1.1239594639422578e-7	1.1239594639422578e-7	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2,SMAD2,AXIN2
GO:0071824	protein-DNA complex organization	1.286434552629165e-7	1.286434552629165e-7	+1	TP53,ARID1A,PBRM1,RB1,DNMT3A,CTCF,NPM1,KDM6A,SOX9,KDM5C,ATRX,BRCA1,FOXA1,SETD2,EP300,SF3B1,TAF1,SIN3A,MECOM,EZH2
GO:0006469	negative regulation of protein kinase activity	1.4676160576857046e-7	1.4676160576857046e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,CDKN1A,MAPK8IP1
GO:0048589	developmental growth	1.5139621783697581e-7	1.5139621783697581e-7	+1	PTEN,NOTCH1,CTNNB1,RUNX1,EPPK1,SOX9,CDKN1B,WT1,ERBB4,FGFR2,USP9X,FGFR3,CDKN1A,SIN3A
GO:0140747	regulation of ncRNA transcription	1.534582537487264e-7	1.534582537487264e-7	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,MTOR,FOXA1,NCOR1
GO:0001933	negative regulation of protein phosphorylation	1.5484042130762187e-7	1.5484042130762187e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,LRRK2,CDKN1A,PPP2R1A,MAPK8IP1
GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1.5505461426562854e-7	1.5505461426562854e-7	+1	PIK3CA,EGFR,GATA3,FLT3,PIK3CG,SOX9,HGF,MTOR,KIT,PDGFRA,FGFR3
GO:2000026	regulation of multicellular organismal development	1.7270173151436476e-7	1.7270173151436476e-7	+1	PTEN,ARID1A,PBRM1,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,RUNX1,PIK3CG,SOX9,WT1,ERBB4,MTOR,TLR4,BRCA1,FGFR2,FOXA2,TGFBR2,SOX17,CBFB,VEZF1,PTPN11,ACVR1B,ACVR2A
GO:0061026	cardiac muscle tissue regeneration	1.894520565534686e-7	1.894520565534686e-7	+1	RUNX1,CDKN1B,ERBB4,CDKN1A
GO:0090399	replicative senescence	2.0169135300138925e-7	2.0169135300138925e-7	+1	TP53,CDKN2A,ATM,CHEK2,ATR
GO:0033002	muscle cell proliferation	2.297968961534426e-7	2.297968961534426e-7	+1	PTEN,PIK3R1,NOTCH1,CTNNB1,RUNX1,AKT1,CDKN1B,ERBB4,FGFR2,CDKN1A
GO:0009895	negative regulation of catabolic process	2.6511222998069597e-7	2.6511222998069597e-7	+1	PIK3CA,VHL,EGFR,CDKN2A,AKT1,HGF,MTOR,LRRK2,EP300,USP9X,TAF1,NCOR1,RPL5,AXIN2
GO:1902893	regulation of miRNA transcription	2.6801596873432846e-7	2.6801596873432846e-7	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,FOXA1,NCOR1
GO:0003176	aortic valve development	2.7179623627969683e-7	2.7179623627969683e-7	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2,SMAD2,AXIN2
GO:0001667	ameboidal-type cell migration	2.82081536754758e-7	2.82081536754758e-7	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,PIK3CG,SOX9,ERBB4,MTOR,KIT,SMAD4,ACVR1B,EGR3
GO:0061614	miRNA transcription	3.0037685824229365e-7	3.0037685824229365e-7	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,FOXA1,NCOR1
GO:0048638	regulation of developmental growth	3.3495805909293114e-7	3.3495805909293114e-7	+1	PTEN,NOTCH1,RUNX1,EPPK1,CDKN1B,WT1,ERBB4,FGFR2,FGFR3,CDKN1A,SIN3A
GO:0035265	organ growth	3.3722713072263e-7	3.3722713072263e-7	+1	PTEN,NOTCH1,RUNX1,SOX9,WT1,ERBB4,FGFR2,FGFR3
GO:0060284	regulation of cell development	3.3927904533830494e-7	3.3927904533830494e-7	+1	PTEN,ARID1A,PBRM1,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,RUNX1,AKT1,MTOR,TLR4,LRRK2,SMAD4,TGFBR2,CBFB,ACVR1B,ACVR2A
GO:0071417	cellular response to organonitrogen compound	3.912987186529616e-7	3.912987186529616e-7	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,AKT1,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,EP300,TAF1,PTPN11
GO:1905314	semi-lunar valve development	5.129352852835194e-7	5.129352852835194e-7	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2,SMAD2,AXIN2
GO:0003007	heart morphogenesis	5.431958044343034e-7	5.431958044343034e-7	+1	APC,GATA3,NOTCH1,CTNNB1,TBX3,SOX9,FGFR2,SMAD4,TGFBR2,SOX17,SMAD2
GO:0030330	DNA damage response, signal transduction by p53 class mediator	5.950942600969596e-7	5.950942600969596e-7	+1	TP53,CDKN2A,ATM,CDKN1B,ATRX,CHEK2,CDKN1A,ATR
GO:0042770	signal transduction in response to DNA damage	6.861910210903859e-7	6.861910210903859e-7	+1	TP53,CDKN2A,ATM,CDKN1B,ATRX,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:0007064	mitotic sister chromatid cohesion	7.201738322240388e-7	7.201738322240388e-7	+1	RB1,STAG2,ATRX,SMC1A,SMC3,RAD21
GO:0044087	regulation of cellular component biogenesis	7.300325388416821e-7	7.300325388416821e-7	+1	TP53,PIK3CA,PTEN,APC,NAV3,PIK3R1,RB1,NOTCH1,ARHGAP35,NPM1,EPHA3,AKT1,AJUBA,ATM,MTOR,TLR4,BRCA1,LRRK2,EP300,SMAD4,ATR,PTPN11
GO:0051054	positive regulation of DNA metabolic process	7.437190024836835e-7	7.437190024836835e-7	+1	ARID1A,PBRM1,EGFR,CTNNB1,AKT1,ATM,WT1,HGF,ATRX,BRCA1,USP9X,ATR,ERCC2
GO:0010631	epithelial cell migration	8.101298899890993e-7	8.101298899890993e-7	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,PIK3CG,SOX9,MTOR,KIT,SMAD4,EGR3
GO:0090132	epithelium migration	8.786431438799431e-7	8.786431438799431e-7	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,PIK3CG,SOX9,MTOR,KIT,SMAD4,EGR3
GO:0009416	response to light stimulus	8.786431438799431e-7	8.786431438799431e-7	+1	TP53,EGFR,NF1,FBXW7,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR
GO:0002521	leukocyte differentiation	0.0000010271312216277555	0.0000010271312216277555	+1	ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,TET2,KIT,TGFBR2,CBFB
GO:0090130	tissue migration	0.000001038640524535952	0.000001038640524535952	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,PIK3CG,SOX9,MTOR,KIT,SMAD4,EGR3
GO:0044819	mitotic G1/S transition checkpoint signaling	0.0000010682350379741283	0.0000010682350379741283	+1	TP53,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
GO:0031571	mitotic G1 DNA damage checkpoint signaling	0.0000010682350379741283	0.0000010682350379741283	+1	TP53,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
GO:2000628	regulation of miRNA metabolic process	0.0000010875495051835589	0.0000010875495051835589	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,FOXA1,NCOR1
GO:1901988	negative regulation of cell cycle phase transition	0.0000011002272555942901	0.0000011002272555942901	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:0007155	cell adhesion	0.0000011261471634008194	0.0000011261471634008194	+1	PIK3CA,PTEN,APC,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,RUNX1,EPHA3,AKT1,PIK3CG,ATM,MTOR,FOXA1,KIT,PDGFRA,FOXA2,TGFBR2,PPP2R1A,CBFB,PTPN11
GO:0016477	cell migration	0.000001161097224294596	0.000001161097224294596	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,SMAD4,USP9X,SIN3A,ACVR1B,EGR3
GO:0034087	establishment of mitotic sister chromatid cohesion	0.0000011752554508156658	0.0000011752554508156658	+1	STAG2,SMC1A,SMC3,RAD21
GO:0048511	rhythmic process	0.0000012190654548924245	0.0000012190654548924245	+1	TP53,PTEN,FBXW7,MTOR,PDGFRA,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:0071479	cellular response to ionizing radiation	0.000001319449788047683	0.000001319449788047683	+1	TP53,GATA3,ATM,BRCA1,BRCA2,CDKN1A,ATR
GO:0007063	regulation of sister chromatid cohesion	0.0000013631639436355334	0.0000013631639436355334	+1	CTNNB1,CTCF,ATRX,AXIN2,RAD21
GO:0022407	regulation of cell-cell adhesion	0.0000014264341552178718	0.0000014264341552178718	+1	PIK3CA,ARID1A,PBRM1,CDKN2A,GATA3,NOTCH1,CDH1,RUNX1,AKT1,MTOR,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.0000014264341552178718	0.0000014264341552178718	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0001944	vasculature development	0.0000014924252324905567	0.0000014924252324905567	+1	PIK3CA,NF1,NOTCH1,FBXW7,CTNNB1,RUNX1,STK11,AKT1,PIK3CG,WT1,BRCA1,KIT,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0061458	reproductive system development	0.000001494307037695682	0.000001494307037695682	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
GO:0048608	reproductive structure development	0.000001494307037695682	0.000001494307037695682	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
GO:0034644	cellular response to UV	0.0000015521697486553724	0.0000015521697486553724	+1	TP53,FBXW7,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0060429	epithelium development	0.0000015621748859332112	0.0000015621748859332112	+1	PTEN,GATA3,NOTCH1,CTNNB1,ARHGAP35,AKT1,EPPK1,SOX9,WT1,HGF,ERBB4,MTOR,FGFR2,SMAD4,BRCA2,TGFBR2,SOX17,VEZF1,SMAD2,ERCC2
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.0000017887579628200813	0.0000017887579628200813	+1	PIK3CA,APC,EGFR,PIK3R1,GATA3,FLT3,EPHA3,AKT1,BRAF,SOX9,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0003203	endocardial cushion morphogenesis	0.0000018088098421083477	0.0000018088098421083477	+1	APC,NOTCH1,TBX3,SOX9,TGFBR2,SMAD2
GO:0000077	DNA damage checkpoint signaling	0.0000018471112257793658	0.0000018471112257793658	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:0048863	stem cell differentiation	0.0000018848125677734674	0.0000018848125677734674	+1	TP53,NOTCH1,CTNNB1,SOX9,ERBB4,KIT,SETD2,PDGFRA,FGFR2,TGFBR2
GO:0051129	negative regulation of cellular component organization	0.0000021344920658023502	0.0000021344920658023502	+1	PIK3CA,PTEN,APC,NAV3,PIK3R1,NOTCH1,NPM1,EPHA3,AKT1,AR,ATM,HGF,MTOR,ATRX,BRCA1,LRRK2,EP300,SMAD4
GO:1903050	regulation of proteolysis involved in protein catabolic process	0.0000022015140525303326	0.0000022015140525303326	+1	PTEN,CDKN2A,FBXW7,KEAP1,CEBPA,AKT1,LRRK2,USP9X,TAF1,RPL5,AXIN2
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	0.0000024162637765854437	0.0000024162637765854437	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B
GO:0042110	T cell activation	0.0000024647446350156393	0.0000024647446350156393	+1	PIK3CA,ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,PIK3CG,MTOR,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:1901991	negative regulation of mitotic cell cycle phase transition	0.000002664753583906668	0.000002664753583906668	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
GO:0051248	negative regulation of protein metabolic process	0.000002691855174516951	0.000002691855174516951	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,CTNNB1,NPM1,CEBPA,AKT1,AJUBA,CDKN1B,LRRK2,USP9X,CDKN1A,TAF1,PPP2R1A,MAPK8IP1,RPL5
GO:0045930	negative regulation of mitotic cell cycle	0.000002783729356193543	0.000002783729356193543	+1	TP53,PTEN,APC,RB1,CTNNB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
GO:0098781	ncRNA transcription	0.000002783729356193543	0.000002783729356193543	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,MTOR,FOXA1,NCOR1
GO:0031647	regulation of protein stability	0.000002829540310892129	0.000002829540310892129	+1	PTEN,VHL,PIK3R1,CDKN2A,FBXW7,MTOR,LRRK2,CHEK2,EP300,USP9X,SOX17,TAF1,RPL5
GO:1902532	negative regulation of intracellular signal transduction	0.000002923027772116033	0.000002923027772116033	+1	PTEN,VHL,NF1,ARHGAP35,NFE2L2,STK11,AKT1,AJUBA,ATM,TLR4,LRRK2,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0050865	regulation of cell activation	0.000002923027772116033	0.000002923027772116033	+1	PIK3CA,ARID1A,PBRM1,CDKN2A,GATA3,RUNX1,CEBPA,AKT1,ATM,MTOR,TLR4,PDGFRA,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0051090	regulation of DNA-binding transcription factor activity	0.0000030152157261504763	0.0000030152157261504763	+1	PTEN,CDKN2A,RB1,KEAP1,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,FOXA2,TAF1
GO:0002009	morphogenesis of an epithelium	0.000003241763691234052	0.000003241763691234052	+1	PTEN,GATA3,NOTCH1,CTNNB1,ARHGAP35,SOX9,WT1,HGF,MTOR,FGFR2,TGFBR2,SOX17
GO:0043085	positive regulation of catalytic activity	0.000003241763691234052	0.000003241763691234052	+1	PTEN,EGFR,NF1,CDKN2A,FBXW7,FLT3,STK11,AKT1,PIK3CG,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,EZH2
GO:0070371	ERK1 and ERK2 cascade	0.000003241763691234052	0.000003241763691234052	+1	EGFR,NOTCH1,FBXW7,BRAF,SOX9,ERBB4,TLR4,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
GO:0007623	circadian rhythm	0.0000032485579516395282	0.0000032485579516395282	+1	TP53,PTEN,FBXW7,MTOR,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:0010212	response to ionizing radiation	0.0000032799429954303825	0.0000032799429954303825	+1	TP53,GATA3,STK11,ATM,BRCA1,BRCA2,CDKN1A,ATR
GO:0050821	protein stabilization	0.0000032799429954303825	0.0000032799429954303825	+1	PTEN,VHL,PIK3R1,CDKN2A,FBXW7,CHEK2,EP300,USP9X,SOX17,TAF1,RPL5
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	0.0000032799429954303825	0.0000032799429954303825	+1	PTEN,FBXW7,KEAP1,CEBPA,AKT1,LRRK2,TAF1,AXIN2
GO:0043405	regulation of MAP kinase activity	0.0000032906916509424594	0.0000032906916509424594	+1	EGFR,NF1,FLT3,PIK3CG,TLR4,LRRK2,CDK12,MAPK8IP1,EZH2
GO:0031570	DNA integrity checkpoint signaling	0.0000032906916509424594	0.0000032906916509424594	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:0046620	regulation of organ growth	0.0000033587090741120182	0.0000033587090741120182	+1	PTEN,NOTCH1,RUNX1,WT1,ERBB4,FGFR2
GO:0010639	negative regulation of organelle organization	0.0000034054942603543763	0.0000034054942603543763	+1	PIK3CA,APC,NAV3,PIK3R1,NPM1,AKT1,ATM,HGF,MTOR,ATRX,BRCA1,LRRK2,SMAD4
GO:0060070	canonical Wnt signaling pathway	0.0000034332740361230286	0.0000034332740361230286	+1	PTEN,APC,EGFR,CTNNB1,STK11,SOX9,LRRK2,FGFR2,SMAD4,SOX17,TBL1XR1,AXIN2
GO:0045860	positive regulation of protein kinase activity	0.000003570903915051174	0.000003570903915051174	+1	EGFR,FBXW7,FLT3,STK11,AKT1,PIK3CG,TLR4,LRRK2,CCND1,TGFBR2,CDKN1A,EZH2
GO:0022409	positive regulation of cell-cell adhesion	0.000003713363120198173	0.000003713363120198173	+1	PIK3CA,ARID1A,PBRM1,GATA3,RUNX1,AKT1,MTOR,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:0007059	chromosome segregation	0.000003767726374973432	0.000003767726374973432	+1	PTEN,APC,ARID1A,PBRM1,RB1,STAG2,ATM,BRCA1,CHEK2,PPP2R1A,SMC1A,SMC3,NCOR1,ERCC2
GO:0098609	cell-cell adhesion	0.000003767726374973432	0.000003767726374973432	+1	PIK3CA,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,RUNX1,AKT1,PIK3CG,MTOR,FOXA1,KIT,PDGFRA,FOXA2,TGFBR2,CBFB,PTPN11
GO:0010586	miRNA metabolic process	0.0000037743826437954745	0.0000037743826437954745	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,FOXA1,NCOR1
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	0.000003840969547501398	0.000003840969547501398	+1	TP53,ATM,CDKN1B,CHEK2,CDKN1A
GO:0002694	regulation of leukocyte activation	0.000003974225956939527	0.000003974225956939527	+1	PIK3CA,ARID1A,PBRM1,CDKN2A,GATA3,RUNX1,CEBPA,AKT1,ATM,MTOR,TLR4,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0006511	ubiquitin-dependent protein catabolic process	0.000004001231413218428	0.000004001231413218428	+1	PTEN,APC,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,AKT1,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP,AXIN2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	0.000004103086107493669	0.000004103086107493669	+1	APC,VHL,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,AKT1,LRRK2,USP9X,TAF1,TBL1XR1,SPOP,AXIN2
GO:0072132	mesenchyme morphogenesis	0.000004450865136658506	0.000004450865136658506	+1	APC,NOTCH1,TBX3,SOX9,TGFBR2,SMAD2
GO:0032880	regulation of protein localization	0.000004569836302390597	0.000004569836302390597	+1	PIK3CA,APC,EGFR,PIK3R1,CDKN2A,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,AR,MTOR,TLR4,LRRK2,SETD2,EP300,FOXA2,SIN3A
GO:0019941	modification-dependent protein catabolic process	0.000004853663961597116	0.000004853663961597116	+1	PTEN,APC,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,AKT1,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP,AXIN2
GO:0051276	chromosome organization	0.000005090894688189024	0.000005090894688189024	+1	APC,ARID1A,PBRM1,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,CHEK2,ATR,SMC1A,SMC3,AXIN2,RAD21,EZH2
GO:0003197	endocardial cushion development	0.000005122470671162333	0.000005122470671162333	+1	APC,NOTCH1,TBX3,SOX9,TGFBR2,SMAD2
GO:0002682	regulation of immune system process	0.000005383474434437391	0.000005383474434437391	+1	PIK3CA,ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,FBXW7,MAP3K1,NFE2L2,RUNX1,MAP2K4,CEBPA,AKT1,SOX9,ATM,MTOR,TLR4,KIT,EP300,TGFBR2,CBFB,SIN3A,PTPN11,ACVR1B,MAPK8IP1,ACVR2A
GO:0045165	cell fate commitment	0.00000555437073430667	0.00000555437073430667	+1	APC,GATA3,TBX3,SOX9,WT1,FGFR2,SMAD4,FOXA2,SOX17,SMAD2
GO:0062197	cellular response to chemical stress	0.000005671313282603216	0.000005671313282603216	+1	TP53,PIK3CA,EGFR,KEAP1,NFE2L2,AKT1,ATM,HGF,MTOR,LRRK2,PDGFRA
GO:0034097	response to cytokine	0.000005789403355149876	0.000005789403355149876	+1	TP53,PIK3R1,GATA3,FLT3,NFE2L2,CEBPA,AKT1,SOX9,TLR4,BRCA1,LRRK2,KIT,SETD2,SMAD4,FOXA2,SIN3A,PTPN11,LIFR
GO:0034085	establishment of sister chromatid cohesion	0.000005791727385143985	0.000005791727385143985	+1	STAG2,SMC1A,SMC3,RAD21
GO:0045321	leukocyte activation	0.000005930178833212096	0.000005930178833212096	+1	PIK3CA,ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,CEBPA,AKT1,PIK3CG,ATM,MTOR,TLR4,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	0.000006086480642100588	0.000006086480642100588	+1	TP53,EGFR,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PPP2R1A,PTPN11
GO:0043632	modification-dependent macromolecule catabolic process	0.000006212051038935929	0.000006212051038935929	+1	PTEN,APC,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,AKT1,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP,AXIN2
GO:0048646	anatomical structure formation involved in morphogenesis	0.000006261999603400894	0.000006261999603400894	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,TBX3,AKT1,PIK3CG,SOX9,WT1,BRCA1,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,TGFBR2,SOX17,EGR3,SMAD2
GO:0014070	response to organic cyclic compound	0.0000062625272075766345	0.0000062625272075766345	+1	ARID1A,EGFR,CTNNB1,CDH1,NPM1,AR,WT1,BRCA1,LRRK2,FOXA1,EP300,TGFBR2,TAF1,NCOR1,SMAD2
GO:1901698	response to nitrogen compound	0.0000065195514842826185	0.0000065195514842826185	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,NPM1,AKT1,SOX9,WT1,MTOR,TLR4,ATRX,BRCA1,LRRK2,EP300,TAF1,PTPN11
GO:0046649	lymphocyte activation	0.000006606632575013419	0.000006606632575013419	+1	PIK3CA,ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,AKT1,PIK3CG,ATM,MTOR,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0033674	positive regulation of kinase activity	0.000006606632575013419	0.000006606632575013419	+1	EGFR,FBXW7,FLT3,STK11,AKT1,PIK3CG,TLR4,LRRK2,CCND1,TGFBR2,CDKN1A,EZH2
GO:0000075	cell cycle checkpoint signaling	0.0000066242321729778736	0.0000066242321729778736	+1	TP53,APC,ATM,CDKN1B,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:0060341	regulation of cellular localization	0.0000068122035680581446	0.0000068122035680581446	+1	PIK3CA,APC,EGFR,PIK3R1,CDKN2A,FBXW7,CTNNB1,CDH1,BAP1,STK11,EPHA3,AKT1,AR,MTOR,TLR4,LRRK2,SETD2,EP300,FOXA2,SIN3A
GO:0002696	positive regulation of leukocyte activation	0.0000068122035680581446	0.0000068122035680581446	+1	PIK3CA,ARID1A,PBRM1,GATA3,RUNX1,CEBPA,AKT1,MTOR,TLR4,TGFBR2,CBFB,PTPN11
GO:0030163	protein catabolic process	0.000006980473728335067	0.000006980473728335067	+1	PTEN,APC,VHL,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,AKT1,CDKN1B,MTOR,LRRK2,CHEK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP,AXIN2
GO:0040012	regulation of locomotion	0.0000072325059631062005	0.0000072325059631062005	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,SIN3A,ACVR1B
GO:0030334	regulation of cell migration	0.000007307883462838616	0.000007307883462838616	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,KIT,PDGFRA,SIN3A,ACVR1B
GO:0007265	Ras protein signal transduction	0.000008300590676085231	0.000008300590676085231	+1	TP53,KRAS,NF1,CDKN2A,RB1,NOTCH1,NRAS,CDKN1A
GO:0009790	embryo development	0.000008660037200790695	0.000008660037200790695	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,WT1,ERBB4,BRCA1,KIT,SETD2,PDGFRA,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0061180	mammary gland epithelium development	0.000008989619320238312	0.000008989619320238312	+1	GATA3,AKT1,ERBB4,FGFR2,BRCA2
GO:0071482	cellular response to light stimulus	0.000009538638746001635	0.000009538638746001635	+1	TP53,FBXW7,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0050863	regulation of T cell activation	0.000009759690230385427	0.000009759690230385427	+1	PIK3CA,ARID1A,PBRM1,CDKN2A,GATA3,RUNX1,AKT1,MTOR,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0001763	morphogenesis of a branching structure	0.000009843902742454327	0.000009843902742454327	+1	CTNNB1,SOX9,WT1,HGF,LRRK2,FGFR2,TGFBR2
GO:0009725	response to hormone	0.000010457552350299886	0.000010457552350299886	+1	PIK3CA,APC,ARID1A,PIK3R1,GATA3,NOTCH1,AKT1,AR,WT1,MTOR,BRCA1,FOXA1,EP300,CCND1,PTPN11,NCOR1
GO:0044092	negative regulation of molecular function	0.000010457552350299886	0.000010457552350299886	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NOTCH1,KEAP1,NPM1,CEBPA,AKT1,CDKN1B,LRRK2,FOXA2,CDKN1A,EIF4A2,MAPK8IP1,RPL5
GO:1902895	positive regulation of miRNA transcription	0.0000109122968274265	0.0000109122968274265	+1	TP53,EGFR,GATA3,AR,WT1,FOXA1
GO:0050678	regulation of epithelial cell proliferation	0.000011015423415250241	0.000011015423415250241	+1	EGFR,NF1,GATA3,FBXW7,NRAS,AKT1,EPPK1,SOX9,FGFR2,BRCA2,EGR3
GO:0018105	peptidyl-serine phosphorylation	0.000011015423415250241	0.000011015423415250241	+1	PTEN,EGFR,AKT1,BRAF,ATM,MTOR,LRRK2,TAF1,ATR,NSD1
GO:0070372	regulation of ERK1 and ERK2 cascade	0.000011015423415250241	0.000011015423415250241	+1	EGFR,NOTCH1,FBXW7,BRAF,ERBB4,TLR4,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
GO:0006281	DNA repair	0.00001111846107464295	0.00001111846107464295	+1	TP53,ARID1A,PBRM1,EGFR,NPM1,ATM,BRCA1,POLQ,CHEK2,SETD2,BRCA2,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:0016055	Wnt signaling pathway	0.000011292624367747604	0.000011292624367747604	+1	PTEN,APC,EGFR,CTNNB1,STK11,SOX9,LRRK2,FGFR2,SMAD4,SOX17,PPP2R1A,TBL1XR1,AXIN2
GO:0048870	cell motility	0.000011368785398628693	0.000011368785398628693	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,SMAD4,USP9X,SIN3A,ACVR1B,EGR3
GO:0040029	epigenetic regulation of gene expression	0.000011368785398628693	0.000011368785398628693	+1	TP53,ARID1A,RB1,DNMT3A,CTCF,ATRX,BRCA1,EP300,SIN3A,EZH2
GO:0050867	positive regulation of cell activation	0.000011368785398628693	0.000011368785398628693	+1	PIK3CA,ARID1A,PBRM1,GATA3,RUNX1,CEBPA,AKT1,MTOR,TLR4,TGFBR2,CBFB,PTPN11
GO:0010507	negative regulation of autophagy	0.000011473497865148617	0.000011473497865148617	+1	PIK3CA,VHL,AKT1,HGF,MTOR,LRRK2,EP300
GO:0051347	positive regulation of transferase activity	0.00001228864808537551	0.00001228864808537551	+1	PTEN,EGFR,FBXW7,FLT3,STK11,AKT1,PIK3CG,TLR4,LRRK2,CCND1,TGFBR2,CDKN1A,EZH2
GO:0001822	kidney development	0.000012536720422764567	0.000012536720422764567	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:0198738	cell-cell signaling by wnt	0.00001259329985231694	0.00001259329985231694	+1	PTEN,APC,EGFR,CTNNB1,STK11,SOX9,LRRK2,FGFR2,SMAD4,SOX17,PPP2R1A,TBL1XR1,AXIN2
GO:0071407	cellular response to organic cyclic compound	0.00001259329985231694	0.00001259329985231694	+1	ARID1A,EGFR,CTNNB1,CDH1,NPM1,AR,WT1,BRCA1,LRRK2,FOXA1,EP300,TAF1,NCOR1
GO:0033044	regulation of chromosome organization	0.000013151804273376871	0.000013151804273376871	+1	APC,ARID1A,PBRM1,RB1,CTNNB1,CTCF,ATM,ATRX,ATR,AXIN2,RAD21
GO:0050870	positive regulation of T cell activation	0.000013486975619786869	0.000013486975619786869	+1	PIK3CA,ARID1A,PBRM1,GATA3,RUNX1,AKT1,MTOR,TGFBR2,CBFB,PTPN11
GO:0044773	mitotic DNA damage checkpoint signaling	0.000013486975619786869	0.000013486975619786869	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
GO:0001775	cell activation	0.000014035573013589039	0.000014035573013589039	+1	PIK3CA,ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,CEBPA,AKT1,PIK3CG,ATM,MTOR,TLR4,KIT,PDGFRA,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0034089	establishment of meiotic sister chromatid cohesion	0.000014396269959804822	0.000014396269959804822	+1	SMC1A,SMC3,RAD21
GO:1903052	positive regulation of proteolysis involved in protein catabolic process	0.000014633572157286456	0.000014633572157286456	+1	PTEN,FBXW7,KEAP1,CEBPA,AKT1,LRRK2,TAF1,AXIN2
GO:0071496	cellular response to external stimulus	0.000015179890342781169	0.000015179890342781169	+1	TP53,MAP3K1,ARHGAP35,MAP2K4,SOX9,MTOR,TLR4,LRRK2,EP300,FOXA2,CDKN1A
GO:0097193	intrinsic apoptotic signaling pathway	0.000015179890342781169	0.000015179890342781169	+1	TP53,FBXW7,NFE2L2,STK11,AKT1,ATM,BRCA1,LRRK2,CHEK2,EP300,CDKN1A
GO:0001666	response to hypoxia	0.000015221497092476946	0.000015221497092476946	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0072001	renal system development	0.000016020205832622054	0.000016020205832622054	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:0007399	nervous system development	0.000016020205832622054	0.000016020205832622054	+1	PTEN,APC,PBRM1,EGFR,NF1,GATA3,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,PRX,ERBB4,LRRK2,FOXA1,EP300,FGFR2,SMAD4,FOXA2,USP9X,TGFBR2,TAF1,SIN3A,PTPN11,ACVR1B,ERCC2
GO:2000145	regulation of cell motility	0.000017541369530797228	0.000017541369530797228	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,KIT,PDGFRA,SIN3A,ACVR1B
GO:0036293	response to decreased oxygen levels	0.000017727724667602084	0.000017727724667602084	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0042176	regulation of protein catabolic process	0.00001780662363660196	0.00001780662363660196	+1	APC,EGFR,FBXW7,KEAP1,CEBPA,AKT1,CDKN1B,LRRK2,CHEK2,USP9X,TAF1,AXIN2
GO:0018209	peptidyl-serine modification	0.00001802985402604899	0.00001802985402604899	+1	PTEN,EGFR,AKT1,BRAF,ATM,MTOR,LRRK2,TAF1,ATR,NSD1
GO:0044774	mitotic DNA integrity checkpoint signaling	0.000018420693729278978	0.000018420693729278978	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
GO:0031929	TOR signaling	0.000019520588921894683	0.000019520588921894683	+1	PIK3CA,VHL,GATA3,STK11,AKT1,ATM,MTOR,EP300,USP9X
GO:0010243	response to organonitrogen compound	0.000019521065453195027	0.000019521065453195027	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,AKT1,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,EP300,TAF1,PTPN11
GO:0006996	organelle organization	0.000020815459981004014	0.000020815459981004014	+1	TP53,PIK3CA,PTEN,APC,ARID1A,PBRM1,NAV3,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,CTCF,NPM1,EPHA3,AKT1,STAG2,AJUBA,EPPK1,ATM,HGF,ERBB4,MTOR,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,SMAD4,USP9X,BRCA2,ATR,SMC1A,SMC3,NCOR1,RPL5,AXIN2,RAD21,EZH2
GO:1903706	regulation of hemopoiesis	0.000020815459981004014	0.000020815459981004014	+1	ARID1A,PBRM1,CDKN2A,GATA3,FBXW7,RUNX1,MTOR,TLR4,TGFBR2,CBFB,ACVR1B,ACVR2A
GO:0007548	sex differentiation	0.000020857710435619713	0.000020857710435619713	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,PTPN11
GO:0001503	ossification	0.000020857710435619713	0.000020857710435619713	+1	EGFR,NF1,NOTCH1,CTNNB1,RUNX1,SOX9,HGF,FGFR2,FGFR3,PTPN11,ACVR2A
GO:0060420	regulation of heart growth	0.000020996673975096968	0.000020996673975096968	+1	NOTCH1,RUNX1,WT1,ERBB4,FGFR2
GO:0050680	negative regulation of epithelial cell proliferation	0.00002130650006794108	0.00002130650006794108	+1	NF1,GATA3,FBXW7,EPPK1,SOX9,FGFR2,BRCA2
GO:0048598	embryonic morphogenesis	0.000021996050106340373	0.000021996050106340373	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,SETD2,PDGFRA,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0071345	cellular response to cytokine stimulus	0.000022027817996904845	0.000022027817996904845	+1	TP53,PIK3R1,GATA3,FLT3,NFE2L2,CEBPA,AKT1,SOX9,TLR4,BRCA1,LRRK2,KIT,SMAD4,SIN3A,PTPN11,LIFR
GO:0035295	tube development	0.00002227306779990796	0.00002227306779990796	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,CEBPA,AKT1,PIK3CG,SOX9,WT1,BRCA1,KIT,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0051249	regulation of lymphocyte activation	0.000023268865632717346	0.000023268865632717346	+1	PIK3CA,ARID1A,PBRM1,CDKN2A,GATA3,RUNX1,AKT1,ATM,MTOR,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0040011	locomotion	0.000023498604598609426	0.000023498604598609426	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,SIN3A,ACVR1B,EGR3
GO:0043276	anoikis	0.000024408302104993386	0.000024408302104993386	+1	PIK3CA,NOTCH1,STK11,AKT1,MTOR
GO:0022612	gland morphogenesis	0.000024408302104993386	0.000024408302104993386	+1	FBXW7,SOX9,HGF,ELF3,FGFR2
GO:0032870	cellular response to hormone stimulus	0.000024792669786799868	0.000024792669786799868	+1	PIK3CA,APC,ARID1A,PIK3R1,NOTCH1,AKT1,AR,WT1,MTOR,BRCA1,FOXA1,EP300,PTPN11,NCOR1
GO:0060828	regulation of canonical Wnt signaling pathway	0.000025624183053362603	0.000025624183053362603	+1	APC,EGFR,STK11,SOX9,LRRK2,FGFR2,SMAD4,SOX17,TBL1XR1,AXIN2
GO:0045785	positive regulation of cell adhesion	0.000025834267775038844	0.000025834267775038844	+1	PIK3CA,ARID1A,PBRM1,GATA3,RUNX1,AKT1,ATM,MTOR,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:0022607	cellular component assembly	0.000026023733025379184	0.000026023733025379184	+1	TP53,PIK3CA,PTEN,APC,NAV3,PIK3R1,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,NPM1,EPHA3,AKT1,STAG2,AJUBA,EPPK1,SOX9,ATM,MTOR,TLR4,ATRX,BRCA1,LRRK2,POLQ,CHEK2,KIT,PDGFRA,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,ATR,SMC1A,PTPN11,SMC3,NCOR1,RPL5
GO:0051091	positive regulation of DNA-binding transcription factor activity	0.00002655156044629131	0.00002655156044629131	+1	PTEN,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,TAF1
GO:2000630	positive regulation of miRNA metabolic process	0.000027495472895508556	0.000027495472895508556	+1	TP53,EGFR,GATA3,AR,WT1,FOXA1
GO:0003151	outflow tract morphogenesis	0.000027495472895508556	0.000027495472895508556	+1	NOTCH1,CTNNB1,FGFR2,SMAD4,TGFBR2,SOX17
GO:0043933	protein-containing complex organization	0.000027667573214610483	0.000027667573214610483	+1	TP53,PIK3CA,APC,ARID1A,PBRM1,NAV3,RB1,DNMT3A,CTCF,NPM1,KDM6A,AJUBA,SOX9,ATM,KDM5C,TLR4,ATRX,BRCA1,LRRK2,POLQ,FOXA1,SETD2,EP300,SF3B1,TAF1,PPP2R1A,ATR,SIN3A,PTPN11,MECOM,RPL5,EZH2
GO:1903039	positive regulation of leukocyte cell-cell adhesion	0.00002985692981852408	0.00002985692981852408	+1	PIK3CA,ARID1A,PBRM1,GATA3,RUNX1,AKT1,MTOR,TGFBR2,CBFB,PTPN11
GO:0035051	cardiocyte differentiation	0.000030352273167372904	0.000030352273167372904	+1	EGFR,NOTCH1,TBX3,WT1,PDGFRA,SMAD4,SOX17
GO:0010506	regulation of autophagy	0.000032342369617934766	0.000032342369617934766	+1	PIK3CA,VHL,FBXW7,KEAP1,STK11,AKT1,ATM,HGF,MTOR,LRRK2,SETD2,EP300
GO:0070602	regulation of centromeric sister chromatid cohesion	0.00003244681279189734	0.00003244681279189734	+1	CTNNB1,CTCF,AXIN2
GO:0071680	response to indole-3-methanol	0.00003244681279189734	0.00003244681279189734	+1	CTNNB1,CDH1,BRCA1
GO:0071681	cellular response to indole-3-methanol	0.00003244681279189734	0.00003244681279189734	+1	CTNNB1,CDH1,BRCA1
GO:0031396	regulation of protein ubiquitination	0.00003340868443181367	0.00003340868443181367	+1	PTEN,CDKN2A,FBXW7,CTNNB1,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0071902	positive regulation of protein serine/threonine kinase activity	0.000034100189848705714	0.000034100189848705714	+1	EGFR,FLT3,AKT1,PIK3CG,TLR4,LRRK2,CCND1,EZH2
GO:1901565	organonitrogen compound catabolic process	0.00003591305592975076	0.00003591305592975076	+1	PTEN,APC,VHL,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,AKT1,CDKN1B,MTOR,TET2,LRRK2,CHEK2,EP300,USP9X,TAF1,TBL1XR1,NCOR1,RPL5,SPOP,AXIN2
GO:0044839	cell cycle G2/M phase transition	0.00003598846654683619	0.00003598846654683619	+1	TP53,CDKN2A,NPM1,ATM,BRCA1,CHEK2,CCND1,CDKN1A
GO:0070482	response to oxygen levels	0.00003622633934263844	0.00003622633934263844	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0070374	positive regulation of ERK1 and ERK2 cascade	0.00003622633934263844	0.00003622633934263844	+1	EGFR,NOTCH1,FBXW7,BRAF,ERBB4,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0045787	positive regulation of cell cycle	0.00003622633934263844	0.00003622633934263844	+1	EGFR,RB1,NPM1,TBX3,AKT1,ATRX,FOXA1,FGFR2,CCND1,RAD21,EZH2
GO:0050673	epithelial cell proliferation	0.00003622633934263844	0.00003622633934263844	+1	EGFR,NF1,GATA3,FBXW7,NRAS,AKT1,EPPK1,SOX9,FGFR2,BRCA2,EGR3
GO:0010629	negative regulation of gene expression	0.000037226837382884597	0.000037226837382884597	+1	VHL,NAV3,RB1,NOTCH1,FBXW7,DNMT3A,NPM1,AKT1,AJUBA,ATM,TLR4,ATRX,BRCA1,LRRK2,TAF1,SIN3A,PTPN11,SMAD2,AXIN2,EZH2
GO:0033365	protein localization to organelle	0.000037226837382884597	0.000037226837382884597	+1	APC,PIK3R1,CDKN2A,RB1,FBXW7,CDH1,CTCF,BAP1,AKT1,MTOR,ATRX,LRRK2,SETD2,EP300,USP9X,BRCA2,ATR,SIN3A,RAD21
GO:1900034	regulation of cellular response to heat	0.000038342467417827174	0.000038342467417827174	+1	ATM,MTOR,EP300,ATR
GO:0022008	neurogenesis	0.00003855758190052385	0.00003855758190052385	+1	PTEN,PBRM1,EGFR,NF1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,PRX,ERBB4,LRRK2,FOXA1,EP300,FGFR2,SMAD4,FOXA2,USP9X,SIN3A,ERCC2
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	0.00003957050944547922	0.00003957050944547922	+1	TP53,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PTPN11
GO:0045732	positive regulation of protein catabolic process	0.0000410698438667826	0.0000410698438667826	+1	APC,FBXW7,KEAP1,CEBPA,AKT1,CDKN1B,LRRK2,TAF1,AXIN2
GO:0030111	regulation of Wnt signaling pathway	0.0000410698438667826	0.0000410698438667826	+1	APC,EGFR,STK11,SOX9,LRRK2,FGFR2,SMAD4,SOX17,PPP2R1A,TBL1XR1,AXIN2
GO:0046661	male sex differentiation	0.00004328855649284792	0.00004328855649284792	+1	GATA3,TBX3,AR,SOX9,WT1,KIT
GO:0033993	response to lipid	0.0000436665154932804	0.0000436665154932804	+1	ARID1A,EGFR,CTNNB1,EPHA3,AR,SOX9,ATM,TLR4,BRCA1,FOXA1,EP300,ASXL1,TGFBR2,NCOR1,SMAD2
GO:0034599	cellular response to oxidative stress	0.0000447799534131876	0.0000447799534131876	+1	TP53,EGFR,KEAP1,NFE2L2,AKT1,ATM,HGF,LRRK2,PDGFRA
GO:1902105	regulation of leukocyte differentiation	0.00004598756302282324	0.00004598756302282324	+1	ARID1A,PBRM1,CDKN2A,GATA3,FBXW7,RUNX1,MTOR,TLR4,TGFBR2,CBFB
GO:0007093	mitotic cell cycle checkpoint signaling	0.00004878696306306444	0.00004878696306306444	+1	TP53,APC,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
GO:0051603	proteolysis involved in protein catabolic process	0.00005260574923441165	0.00005260574923441165	+1	PTEN,APC,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,AKT1,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP,AXIN2
GO:0001501	skeletal system development	0.0000531347777122933	0.0000531347777122933	+1	TP53,FBXW7,CTNNB1,RUNX1,TBX3,SOX9,PDGFRA,FGFR2,FGFR3,TGFBR2,PTPN11
GO:0010498	proteasomal protein catabolic process	0.00005344601372133016	0.00005344601372133016	+1	APC,VHL,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,AKT1,LRRK2,USP9X,TAF1,TBL1XR1,SPOP,AXIN2
GO:1901800	positive regulation of proteasomal protein catabolic process	0.00005448357214448741	0.00005448357214448741	+1	FBXW7,KEAP1,CEBPA,AKT1,LRRK2,TAF1,AXIN2
GO:1902749	regulation of cell cycle G2/M phase transition	0.00005448357214448741	0.00005448357214448741	+1	TP53,CDKN2A,NPM1,ATM,BRCA1,CCND1,CDKN1A
GO:0042246	tissue regeneration	0.000055146836091242176	0.000055146836091242176	+1	RUNX1,EPPK1,CDKN1B,ERBB4,CDKN1A
GO:0016567	protein ubiquitination	0.000055876648425226604	0.000055876648425226604	+1	PTEN,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,AKT1,BRCA1,LRRK2,USP9X,BRCA2,TAF1,CBFB,RPL5,SPOP
GO:0061138	morphogenesis of a branching epithelium	0.00005591533477527526	0.00005591533477527526	+1	CTNNB1,SOX9,WT1,HGF,FGFR2,TGFBR2
GO:0070727	cellular macromolecule localization	0.00005748805718376782	0.00005748805718376782	+1	TP53,PIK3CA,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,EPHA3,AKT1,BRAF,AR,ATM,MTOR,TLR4,ATRX,LRRK2,SETD2,EP300,FOXA2,USP9X,BRCA2,ATR,SIN3A,AXIN2,RAD21
GO:1903037	regulation of leukocyte cell-cell adhesion	0.00005759099683174361	0.00005759099683174361	+1	PIK3CA,ARID1A,PBRM1,CDKN2A,GATA3,RUNX1,AKT1,MTOR,TGFBR2,CBFB,PTPN11
GO:0070828	heterochromatin organization	0.00005759099683174361	0.00005759099683174361	+1	RB1,DNMT3A,ATRX,BRCA1,SIN3A,MECOM,EZH2
GO:0048699	generation of neurons	0.00005819406829221105	0.00005819406829221105	+1	PTEN,PBRM1,NF1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,ERBB4,LRRK2,FOXA1,EP300,FGFR2,SMAD4,FOXA2,USP9X,SIN3A,ERCC2
GO:0003348	cardiac endothelial cell differentiation	0.00005979001406184843	0.00005979001406184843	+1	NOTCH1,SMAD4,SOX17
GO:0060956	endocardial cell differentiation	0.00005979001406184843	0.00005979001406184843	+1	NOTCH1,SMAD4,SOX17
GO:0001708	cell fate specification	0.00006031289208717514	0.00006031289208717514	+1	APC,TBX3,SOX9,SMAD4,FOXA2,SOX17
GO:0031329	regulation of cellular catabolic process	0.00006080569565830415	0.00006080569565830415	+1	PIK3CA,VHL,CDKN2A,FBXW7,KEAP1,NPM1,STK11,AKT1,ATM,HGF,MTOR,LRRK2,SETD2,EP300,NCOR1,AXIN2
GO:0048738	cardiac muscle tissue development	0.00006137597439388792	0.00006137597439388792	+1	NOTCH1,RUNX1,TBX3,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0031330	negative regulation of cellular catabolic process	0.00006137597439388792	0.00006137597439388792	+1	PIK3CA,VHL,AKT1,HGF,MTOR,LRRK2,EP300,NCOR1,AXIN2
GO:0060419	heart growth	0.00006137597439388792	0.00006137597439388792	+1	NOTCH1,RUNX1,WT1,ERBB4,FGFR2
GO:0030099	myeloid cell differentiation	0.00006236621285161005	0.00006236621285161005	+1	GATA3,FBXW7,RUNX1,CEBPA,MTOR,TLR4,TET2,KIT,TGFBR2,ACVR1B,ACVR2A
GO:0030098	lymphocyte differentiation	0.00007088947455117692	0.00007088947455117692	+1	ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,ATM,KIT,TGFBR2,CBFB
GO:0009057	macromolecule catabolic process	0.00007207689159963159	0.00007207689159963159	+1	PTEN,APC,VHL,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,CEBPA,AKT1,ATM,CDKN1B,MTOR,LRRK2,CHEK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP,AXIN2
GO:0002376	immune system process	0.00007652667912752938	0.00007652667912752938	+1	TP53,PIK3CA,ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,MAP3K1,FLT3,NFE2L2,RUNX1,MAP2K4,CEBPA,AKT1,PIK3CG,SOX9,ATM,MTOR,TLR4,POLQ,KIT,SETD2,EP300,TGFBR2,PPP2R1A,CBFB,SIN3A,PTPN11,ACVR1B,MAPK8IP1,ACVR2A
GO:0007259	receptor signaling pathway via JAK-STAT	0.00007819870269668055	0.00007819870269668055	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,EP300,FGFR3,PPP2R1A
GO:0003281	ventricular septum development	0.00007819870269668055	0.00007819870269668055	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0035239	tube morphogenesis	0.00007819870269668055	0.00007819870269668055	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,PIK3CG,SOX9,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0048872	homeostasis of number of cells	0.00007819870269668055	0.00007819870269668055	+1	NOTCH1,FLT3,AKT1,SOX9,KIT,PPP2R1A,ACVR1B,ACVR2A
GO:0009880	embryonic pattern specification	0.00007819870269668055	0.00007819870269668055	+1	TBX3,WT1,ERBB4,FGFR2,SMAD2
GO:0014706	striated muscle tissue development	0.00008172444609366382	0.00008172444609366382	+1	NOTCH1,RUNX1,TBX3,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0009612	response to mechanical stimulus	0.00008172444609366382	0.00008172444609366382	+1	PIK3CA,CTNNB1,MAP3K1,MAP2K4,SOX9,TLR4,KIT
GO:0034614	cellular response to reactive oxygen species	0.00008172444609366382	0.00008172444609366382	+1	EGFR,NFE2L2,AKT1,ATM,HGF,LRRK2,PDGFRA
GO:0030182	neuron differentiation	0.0000839452421722412	0.0000839452421722412	+1	PTEN,PBRM1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,ERBB4,LRRK2,FOXA1,EP300,FGFR2,SMAD4,FOXA2,USP9X,SIN3A,ERCC2
GO:0051251	positive regulation of lymphocyte activation	0.00009350764387484634	0.00009350764387484634	+1	PIK3CA,ARID1A,PBRM1,GATA3,RUNX1,AKT1,MTOR,TGFBR2,CBFB,PTPN11
GO:1900180	regulation of protein localization to nucleus	0.00010387945235353194	0.00010387945235353194	+1	PIK3R1,CDKN2A,CDH1,AKT1,MTOR,EP300,SIN3A
GO:0097696	receptor signaling pathway via STAT	0.00010387945235353194	0.00010387945235353194	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,EP300,FGFR3,PPP2R1A
GO:0007389	pattern specification process	0.00010690873202663831	0.00010690873202663831	+1	APC,NOTCH1,TBX3,WT1,ERBB4,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0060421	positive regulation of heart growth	0.00011050231982964343	0.00011050231982964343	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0003181	atrioventricular valve morphogenesis	0.00011050231982964343	0.00011050231982964343	+1	NOTCH1,SMAD4,TGFBR2,AXIN2
GO:0046622	positive regulation of organ growth	0.00011050231982964343	0.00011050231982964343	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0030217	T cell differentiation	0.00011943389065742973	0.00011943389065742973	+1	ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,RUNX1,KIT,TGFBR2,CBFB
GO:0038127	ERBB signaling pathway	0.00012276859993351155	0.00012276859993351155	+1	PIK3CA,EGFR,AKT1,BRAF,SOX9,ERBB4,PTPN11
GO:1903829	positive regulation of protein localization	0.00012779116489749226	0.00012779116489749226	+1	PIK3CA,APC,EGFR,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,EPHA3,AKT1,TLR4,EP300
GO:0060043	regulation of cardiac muscle cell proliferation	0.00013320952547910784	0.00013320952547910784	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0010518	positive regulation of phospholipase activity	0.00013618032689460515	0.00013618032689460515	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0034502	protein localization to chromosome	0.00013683063951016005	0.00013683063951016005	+1	RB1,CTCF,ATRX,SETD2,BRCA2,ATR,RAD21
GO:0010632	regulation of epithelial cell migration	0.0001380197168514412	0.0001380197168514412	+1	PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,PIK3CG,SOX9,MTOR
GO:0008104	protein localization	0.00013843808285583868	0.00013843808285583868	+1	TP53,PIK3CA,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,EPHA3,AKT1,BRAF,AR,MTOR,TLR4,ATRX,LRRK2,SETD2,EP300,FOXA2,USP9X,BRCA2,ATR,SIN3A,AXIN2,RAD21
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	0.00013967128484258806	0.00013967128484258806	+1	KEAP1,CEBPA,AKT1,LRRK2,TAF1,AXIN2
GO:0060562	epithelial tube morphogenesis	0.00014042532646195495	0.00014042532646195495	+1	GATA3,NOTCH1,CTNNB1,SOX9,WT1,FGFR2,TGFBR2,SOX17
GO:0048514	blood vessel morphogenesis	0.00014539631243448432	0.00014539631243448432	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,PIK3CG,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:1903320	regulation of protein modification by small protein conjugation or removal	0.0001475842692215551	0.0001475842692215551	+1	PTEN,CDKN2A,FBXW7,CTNNB1,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0043406	positive regulation of MAP kinase activity	0.0001493809057013615	0.0001493809057013615	+1	EGFR,FLT3,PIK3CG,TLR4,LRRK2,EZH2
GO:0003157	endocardium development	0.0001527281395289282	0.0001527281395289282	+1	NOTCH1,SMAD4,SOX17
GO:0044085	cellular component biogenesis	0.0001559687739973457	0.0001559687739973457	+1	TP53,PIK3CA,PTEN,APC,NAV3,PIK3R1,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,NPM1,EPHA3,AKT1,STAG2,AJUBA,EPPK1,SOX9,ATM,MTOR,TLR4,ATRX,BRCA1,LRRK2,POLQ,CHEK2,KIT,PDGFRA,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,ATR,SMC1A,PTPN11,SMC3,NCOR1,RPL5
GO:0016242	negative regulation of macroautophagy	0.00015652216999152333	0.00015652216999152333	+1	PIK3CA,AKT1,MTOR,LRRK2
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	0.00015870359734079963	0.00015870359734079963	+1	KEAP1,CEBPA,AKT1,LRRK2,USP9X,TAF1,AXIN2
GO:0006979	response to oxidative stress	0.00015870359734079963	0.00015870359734079963	+1	TP53,EGFR,KEAP1,NFE2L2,AKT1,ATM,HGF,LRRK2,PDGFRA,ERCC2
GO:0030335	positive regulation of cell migration	0.00016096357271516633	0.00016096357271516633	+1	APC,EGFR,GATA3,NOTCH1,AKT1,PIK3CG,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:0048568	embryonic organ development	0.00016247047578794112	0.00016247047578794112	+1	GATA3,NOTCH1,CTNNB1,SOX9,KIT,PDGFRA,FGFR2,TGFBR2,SOX17
GO:1901873	regulation of post-translational protein modification	0.00016247047578794112	0.00016247047578794112	+1	PTEN,CDKN2A,FBXW7,CTNNB1,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0007159	leukocyte cell-cell adhesion	0.00016264439454455142	0.00016264439454455142	+1	PIK3CA,ARID1A,PBRM1,CDKN2A,GATA3,RUNX1,AKT1,MTOR,TGFBR2,CBFB,PTPN11
GO:0007010	cytoskeleton organization	0.00016272157814561865	0.00016272157814561865	+1	PIK3CA,PTEN,APC,NAV3,NF1,PIK3R1,CTNNB1,ARHGAP35,NPM1,EPHA3,STAG2,AJUBA,EPPK1,MTOR,BRCA1,CHEK2,KIT,SETD2,PDGFRA,SMAD4,BRCA2,SMC1A,SMC3,NCOR1
GO:0001656	metanephros development	0.00016272157814561865	0.00016272157814561865	+1	NF1,SOX9,WT1,PDGFRA,SOX17
GO:0045445	myoblast differentiation	0.00016902212560150162	0.00016902212560150162	+1	ARID1A,PBRM1,RB1,NOTCH1,TBX3,SOX9
GO:0030855	epithelial cell differentiation	0.00017801655309739826	0.00017801655309739826	+1	GATA3,NOTCH1,CTNNB1,AKT1,SOX9,WT1,ERBB4,FGFR2,SMAD4,SOX17,VEZF1,SMAD2,ERCC2
GO:0002573	myeloid leukocyte differentiation	0.00017801655309739826	0.00017801655309739826	+1	GATA3,FBXW7,RUNX1,CEBPA,MTOR,TLR4,KIT,TGFBR2
GO:0031297	replication fork processing	0.00017919418338211665	0.00017919418338211665	+1	ATRX,BRCA1,POLQ,BRCA2,ATR
GO:0003171	atrioventricular valve development	0.0001820656586027258	0.0001820656586027258	+1	NOTCH1,SMAD4,TGFBR2,AXIN2
GO:0051130	positive regulation of cellular component organization	0.00018625187907509436	0.00018625187907509436	+1	TP53,PIK3CA,APC,NAV3,PIK3R1,RB1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AR,AJUBA,ATM,TLR4,ATRX,EP300,SMAD4,ATR,RAD21
GO:0000819	sister chromatid segregation	0.0001918594200527346	0.0001918594200527346	+1	APC,ARID1A,PBRM1,RB1,STAG2,ATM,CHEK2,SMC1A,SMC3
GO:0061136	regulation of proteasomal protein catabolic process	0.00019246575167179887	0.00019246575167179887	+1	FBXW7,KEAP1,CEBPA,AKT1,LRRK2,USP9X,TAF1,AXIN2
GO:1903131	mononuclear cell differentiation	0.0001940524007000837	0.0001940524007000837	+1	ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,ATM,KIT,TGFBR2,CBFB
GO:0048145	regulation of fibroblast proliferation	0.00019612200258511386	0.00019612200258511386	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.00019747288375365952	0.00019747288375365952	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,SIN3A,ACVR1B,ACVR2A,SMAD2
GO:0062014	negative regulation of small molecule metabolic process	0.00020480075169052272	0.00020480075169052272	+1	TP53,AKT1,SOX9,BRCA1,EP300,NCOR1
GO:0060038	cardiac muscle cell proliferation	0.00021224095668370308	0.00021224095668370308	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0032446	protein modification by small protein conjugation	0.00021446122831553197	0.00021446122831553197	+1	PTEN,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,AKT1,BRCA1,LRRK2,USP9X,BRCA2,TAF1,CBFB,RPL5,SPOP
GO:0048144	fibroblast proliferation	0.00021459885095169426	0.00021459885095169426	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:0061323	cell proliferation involved in heart morphogenesis	0.0002157983853056284	0.0002157983853056284	+1	NOTCH1,TBX3,SMAD4
GO:2000136	regulation of cell proliferation involved in heart morphogenesis	0.0002157983853056284	0.0002157983853056284	+1	NOTCH1,TBX3,SMAD4
GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	0.0002157983853056284	0.0002157983853056284	+1	NOTCH1,STK11,EP300,SMAD4,USP9X,TGFBR2,SIN3A,ACVR1B,ACVR2A,SMAD2
GO:0070647	protein modification by small protein conjugation or removal	0.00021619017204117612	0.00021619017204117612	+1	PTEN,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,BAP1,AKT1,BRCA1,LRRK2,USP9X,BRCA2,TAF1,CBFB,RPL5,SPOP
GO:0001525	angiogenesis	0.00021788826155983264	0.00021788826155983264	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,PIK3CG,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0098813	nuclear chromosome segregation	0.00022058423500364086	0.00022058423500364086	+1	PTEN,APC,ARID1A,PBRM1,RB1,STAG2,ATM,CHEK2,SMC1A,SMC3
GO:0060537	muscle tissue development	0.00022338716918421906	0.00022338716918421906	+1	NF1,NOTCH1,RUNX1,TBX3,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0045582	positive regulation of T cell differentiation	0.00023011847370449395	0.00023011847370449395	+1	ARID1A,PBRM1,GATA3,RUNX1,TGFBR2,CBFB
GO:0010721	negative regulation of cell development	0.00023126120091500343	0.00023126120091500343	+1	PTEN,NF1,CDKN2A,NOTCH1,FBXW7,RUNX1,TLR4,CBFB
GO:1903053	regulation of extracellular matrix organization	0.00023213739763027665	0.00023213739763027665	+1	RB1,NOTCH1,RUNX1,SMAD4,AXIN2
GO:2001233	regulation of apoptotic signaling pathway	0.00023241316271149459	0.00023241316271149459	+1	TP53,RB1,FBXW7,NFE2L2,AKT1,AR,HGF,TLR4,BRCA1,LRRK2
GO:2000147	positive regulation of cell motility	0.0002384542281440047	0.0002384542281440047	+1	APC,EGFR,GATA3,NOTCH1,AKT1,PIK3CG,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:0060688	regulation of morphogenesis of a branching structure	0.00024202941557622097	0.00024202941557622097	+1	SOX9,HGF,LRRK2,FGFR2
GO:0055021	regulation of cardiac muscle tissue growth	0.00024202941557622097	0.00024202941557622097	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0009605	response to external stimulus	0.0002467558703008166	0.0002467558703008166	+1	TP53,PIK3CA,PTEN,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,MAP3K1,ARHGAP35,NFE2L2,MAP2K4,CEBPA,AKT1,EPPK1,PIK3CG,SOX9,HGF,MTOR,TLR4,LRRK2,KIT,SETD2,PDGFRA,EP300,FOXA2,CDKN1A,SIN3A,PTPN11,EGR3
GO:0000302	response to reactive oxygen species	0.0002518330757061724	0.0002518330757061724	+1	EGFR,NFE2L2,AKT1,ATM,HGF,LRRK2,PDGFRA
GO:0003208	cardiac ventricle morphogenesis	0.00025206076955034746	0.00025206076955034746	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0051494	negative regulation of cytoskeleton organization	0.0002634848692161194	0.0002634848692161194	+1	PIK3CA,APC,NAV3,PIK3R1,NPM1,BRCA1,SMAD4
GO:0045580	regulation of T cell differentiation	0.0002634848692161194	0.0002634848692161194	+1	ARID1A,PBRM1,CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:0009896	positive regulation of catabolic process	0.00026796722375599895	0.00026796722375599895	+1	PTEN,APC,FBXW7,KEAP1,STK11,CEBPA,AKT1,CDKN1B,MTOR,LRRK2,SETD2,TAF1,AXIN2
GO:0010517	regulation of phospholipase activity	0.00027469263250819783	0.00027469263250819783	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0048512	circadian behavior	0.00027779927647980543	0.00027779927647980543	+1	TP53,PTEN,MTOR,NCOR1
GO:0001568	blood vessel development	0.00027779927647980543	0.00027779927647980543	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,PIK3CG,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0007622	rhythmic behavior	0.00027779927647980543	0.00027779927647980543	+1	TP53,PTEN,MTOR,NCOR1
GO:0040017	positive regulation of locomotion	0.0002833446131619001	0.0002833446131619001	+1	APC,EGFR,GATA3,NOTCH1,AKT1,PIK3CG,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:0008406	gonad development	0.00028832614139759284	0.00028832614139759284	+1	GATA3,AR,SOX9,WT1,KIT,PDGFRA
GO:0048660	regulation of smooth muscle cell proliferation	0.00028832614139759284	0.00028832614139759284	+1	PTEN,PIK3R1,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:0048705	skeletal system morphogenesis	0.00028832614139759284	0.00028832614139759284	+1	CTNNB1,SOX9,PDGFRA,FGFR2,FGFR3,TGFBR2
GO:0071456	cellular response to hypoxia	0.00028832614139759284	0.00028832614139759284	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR
GO:0002053	positive regulation of mesenchymal cell proliferation	0.00029069085955063826	0.00029069085955063826	+1	SOX9,FGFR2,TGFBR2
GO:0070601	centromeric sister chromatid cohesion	0.00029069085955063826	0.00029069085955063826	+1	CTNNB1,CTCF,AXIN2
GO:0045475	locomotor rhythm	0.00029069085955063826	0.00029069085955063826	+1	PTEN,MTOR,NCOR1
GO:0061061	muscle structure development	0.0003038244871320983	0.0003038244871320983	+1	ARID1A,PBRM1,RB1,NOTCH1,TBX3,SOX9,WT1,KIT,PDGFRA,FGFR2,SMAD4,EGR3
GO:0046425	regulation of receptor signaling pathway via JAK-STAT	0.00030461224671417427	0.00030461224671417427	+1	VHL,NOTCH1,ERBB4,KIT,EP300,PPP2R1A
GO:0043409	negative regulation of MAPK cascade	0.00031217535541614865	0.00031217535541614865	+1	NF1,TLR4,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0140694	non-membrane-bounded organelle assembly	0.00031554180760130535	0.00031554180760130535	+1	PTEN,NPM1,STAG2,BRCA1,CHEK2,PDGFRA,SMAD4,SMC1A,SMC3,NCOR1,RPL5
GO:0022603	regulation of anatomical structure morphogenesis	0.0003159421319897141	0.0003159421319897141	+1	PTEN,NF1,GATA3,CTNNB1,ARHGAP35,RUNX1,PIK3CG,SOX9,WT1,HGF,BRCA1,LRRK2,KIT,FGFR2,FOXA2
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.00031670900522415426	0.00031670900522415426	+1	NOTCH1,STK11,EP300,SMAD4,USP9X,TGFBR2,SIN3A,ACVR1B,ACVR2A,SMAD2
GO:0008584	male gonad development	0.00031811450051668434	0.00031811450051668434	+1	GATA3,AR,SOX9,WT1,KIT
GO:0060193	positive regulation of lipase activity	0.00031811450051668434	0.00031811450051668434	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0048659	smooth muscle cell proliferation	0.00031875999261801356	0.00031875999261801356	+1	PTEN,PIK3R1,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:1901989	positive regulation of cell cycle phase transition	0.00031875999261801356	0.00031875999261801356	+1	EGFR,RB1,NPM1,AKT1,CCND1,EZH2
GO:0045137	development of primary sexual characteristics	0.00031875999261801356	0.00031875999261801356	+1	GATA3,AR,SOX9,WT1,KIT,PDGFRA
GO:0031507	heterochromatin formation	0.00031875999261801356	0.00031875999261801356	+1	RB1,DNMT3A,ATRX,BRCA1,SIN3A,EZH2
GO:0022414	reproductive process	0.0003220063692423448	0.0003220063692423448	+1	PTEN,GATA3,DNMT3A,CTCF,TBX3,AR,SOX9,ATM,WT1,KIT,PDGFRA,FGFR2,USP9X,SMC1A,PTPN11,ACVR1B,SMC3,RAD21
GO:0036294	cellular response to decreased oxygen levels	0.0003380775491040832	0.0003380775491040832	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR
GO:0045005	DNA-templated DNA replication maintenance of fidelity	0.0003395846111557665	0.0003395846111557665	+1	ATRX,BRCA1,POLQ,BRCA2,ATR
GO:0046546	development of primary male sexual characteristics	0.0003395846111557665	0.0003395846111557665	+1	GATA3,AR,SOX9,WT1,KIT
GO:0045922	negative regulation of fatty acid metabolic process	0.0003495891574853066	0.0003495891574853066	+1	AKT1,SOX9,BRCA1,NCOR1
GO:0060412	ventricular septum morphogenesis	0.0003495891574853066	0.0003495891574853066	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0071364	cellular response to epidermal growth factor stimulus	0.0003495891574853066	0.0003495891574853066	+1	EGFR,AKT1,SOX9,PTPN11
GO:0006914	autophagy	0.00035083743404532166	0.00035083743404532166	+1	TP53,PIK3CA,VHL,FBXW7,KEAP1,STK11,AKT1,ATM,HGF,MTOR,LRRK2,SETD2,EP300
GO:0061919	process utilizing autophagic mechanism	0.00035083743404532166	0.00035083743404532166	+1	TP53,PIK3CA,VHL,FBXW7,KEAP1,STK11,AKT1,ATM,HGF,MTOR,LRRK2,SETD2,EP300
GO:0000003	reproduction	0.000352828658986435	0.000352828658986435	+1	PTEN,GATA3,DNMT3A,CTCF,TBX3,AR,SOX9,ATM,WT1,KIT,PDGFRA,FGFR2,USP9X,SMC1A,PTPN11,ACVR1B,SMC3,RAD21
GO:0006302	double-strand break repair	0.0003609631368691208	0.0003609631368691208	+1	ARID1A,PBRM1,ATM,BRCA1,POLQ,CHEK2,SETD2,BRCA2,ATR,RAD21
GO:0072497	mesenchymal stem cell differentiation	0.0003759907694478491	0.0003759907694478491	+1	CTNNB1,SOX9,PDGFRA
GO:0051177	meiotic sister chromatid cohesion	0.0003759907694478491	0.0003759907694478491	+1	SMC1A,SMC3,RAD21
GO:0048562	embryonic organ morphogenesis	0.0003761570184877223	0.0003761570184877223	+1	NOTCH1,CTNNB1,SOX9,PDGFRA,FGFR2,TGFBR2,SOX17
GO:0030522	intracellular receptor signaling pathway	0.00037938086747260966	0.00037938086747260966	+1	ARID1A,AKT1,AR,TLR4,BRCA1,FOXA1,EP300,ASXL1,NCOR1,EZH2
GO:0030162	regulation of proteolysis	0.00039239539981855145	0.00039239539981855145	+1	PTEN,CDKN2A,FBXW7,KEAP1,RUNX1,CEBPA,AKT1,LRRK2,USP9X,TAF1,RPL5,SPOP,AXIN2
GO:0045661	regulation of myoblast differentiation	0.00039239539981855145	0.00039239539981855145	+1	ARID1A,PBRM1,NOTCH1,TBX3,SOX9
GO:1904892	regulation of receptor signaling pathway via STAT	0.00041391922724966245	0.00041391922724966245	+1	VHL,NOTCH1,ERBB4,KIT,EP300,PPP2R1A
GO:0043687	post-translational protein modification	0.0004209054435362289	0.0004209054435362289	+1	PTEN,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,BAP1,AKT1,BRCA1,LRRK2,USP9X,BRCA2,TAF1,CBFB,RPL5,SPOP
GO:0051098	regulation of binding	0.00043173747642467046	0.00043173747642467046	+1	GATA3,RB1,AKT1,LRRK2,USP9X,CDKN1A,TAF1,NSD1,SMAD2
GO:0007173	epidermal growth factor receptor signaling pathway	0.0004359980692271131	0.0004359980692271131	+1	PIK3CA,EGFR,AKT1,BRAF,SOX9,PTPN11
GO:0038202	TORC1 signaling	0.0004359980692271131	0.0004359980692271131	+1	VHL,STK11,AKT1,ATM,MTOR,EP300
GO:0032006	regulation of TOR signaling	0.000445237409281925	0.000445237409281925	+1	PIK3CA,VHL,STK11,AKT1,ATM,EP300,USP9X
GO:0031099	regeneration	0.00045620074230072184	0.00045620074230072184	+1	RUNX1,EPPK1,CDKN1B,ERBB4,CDKN1A
GO:0048754	branching morphogenesis of an epithelial tube	0.00045620074230072184	0.00045620074230072184	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
GO:0045621	positive regulation of lymphocyte differentiation	0.00045895996049673336	0.00045895996049673336	+1	ARID1A,PBRM1,GATA3,RUNX1,TGFBR2,CBFB
GO:0042752	regulation of circadian rhythm	0.0004852300002777744	0.0004852300002777744	+1	TP53,FBXW7,MTOR,USP9X,SIN3A,EZH2
GO:0036302	atrioventricular canal development	0.0004854894089701233	0.0004854894089701233	+1	TBX3,SMAD4,PTPN11
GO:0051547	regulation of keratinocyte migration	0.0004854894089701233	0.0004854894089701233	+1	PTEN,EPPK1,MTOR
GO:0000226	microtubule cytoskeleton organization	0.00048647555962833954	0.00048647555962833954	+1	PTEN,APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,CHEK2,SETD2,BRCA2,SMC1A,SMC3,NCOR1
GO:0048871	multicellular organismal-level homeostasis	0.00048748458673147346	0.00048748458673147346	+1	APC,NF1,RB1,NOTCH1,FLT3,STK11,AKT1,SOX9,TLR4,KIT,PPP2R1A,ACVR1B,ACVR2A
GO:0070849	response to epidermal growth factor	0.0004974707353038156	0.0004974707353038156	+1	EGFR,AKT1,SOX9,PTPN11
GO:0055017	cardiac muscle tissue growth	0.0004974707353038156	0.0004974707353038156	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0010828	positive regulation of glucose transmembrane transport	0.0004974707353038156	0.0004974707353038156	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0019827	stem cell population maintenance	0.0005067941907952941	0.0005067941907952941	+1	ARID1A,NOTCH1,CTNNB1,SOX9,KIT,SIN3A
GO:0003279	cardiac septum development	0.0005247397871843555	0.0005247397871843555	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:1901575	organic substance catabolic process	0.0005333747704133778	0.0005333747704133778	+1	TP53,PTEN,APC,VHL,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,CEBPA,AKT1,ATM,CDKN1B,MTOR,TET2,LRRK2,CHEK2,EP300,USP9X,TAF1,TBL1XR1,NCOR1,RPL5,SPOP,AXIN2
GO:0098727	maintenance of cell number	0.0005333747704133778	0.0005333747704133778	+1	ARID1A,NOTCH1,CTNNB1,SOX9,KIT,SIN3A
GO:0010719	negative regulation of epithelial to mesenchymal transition	0.0005583632523865324	0.0005583632523865324	+1	PTEN,GATA3,FOXA1,FOXA2
GO:0042509	regulation of tyrosine phosphorylation of STAT protein	0.0005630291703028817	0.0005630291703028817	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0009056	catabolic process	0.0005860624017776932	0.0005860624017776932	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,STK11,CEBPA,AKT1,ATM,CDKN1B,HGF,MTOR,TET2,LRRK2,CHEK2,SETD2,EP300,USP9X,TAF1,TBL1XR1,NCOR1,RPL5,SPOP,AXIN2
GO:2000377	regulation of reactive oxygen species metabolic process	0.0005916317096776352	0.0005916317096776352	+1	TP53,TLR4,BRCA1,LRRK2,TGFBR2,CDKN1A
GO:0033036	macromolecule localization	0.0006107231817791365	0.0006107231817791365	+1	TP53,PIK3CA,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,EPHA3,AKT1,BRAF,AR,ATM,MTOR,TLR4,ATRX,LRRK2,SETD2,EP300,FOXA2,USP9X,BRCA2,TGFBR2,ATR,SIN3A,AXIN2,RAD21
GO:2000146	negative regulation of cell motility	0.0006182904356843774	0.0006182904356843774	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,SIN3A
GO:2000278	regulation of DNA biosynthetic process	0.0006205425126871267	0.0006205425126871267	+1	TP53,CTNNB1,ATM,HGF,CDKN1A,ATR
GO:0071453	cellular response to oxygen levels	0.0006205425126871267	0.0006205425126871267	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR
GO:0014855	striated muscle cell proliferation	0.0006212131761553327	0.0006212131761553327	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0071560	cellular response to transforming growth factor beta stimulus	0.0006435400898736575	0.0006435400898736575	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,SIN3A,SMAD2
GO:0007260	tyrosine phosphorylation of STAT protein	0.0006436289536555723	0.0006436289536555723	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0045619	regulation of lymphocyte differentiation	0.0006564761327469649	0.0006564761327469649	+1	ARID1A,PBRM1,CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:0071897	DNA biosynthetic process	0.0007417077827414843	0.0007417077827414843	+1	TP53,CTNNB1,ATM,HGF,POLQ,CDKN1A,ATR
GO:0007264	small GTPase-mediated signal transduction	0.0007555734266985298	0.0007555734266985298	+1	TP53,KRAS,NF1,CDKN2A,RB1,NOTCH1,ARHGAP35,NRAS,PIK3CG,LRRK2,CDKN1A
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	0.000759661484584085	0.000759661484584085	+1	EGFR,AKT1,CCND1
GO:0003214	cardiac left ventricle morphogenesis	0.000759661484584085	0.000759661484584085	+1	NOTCH1,SMAD4,TGFBR2
GO:0048701	embryonic cranial skeleton morphogenesis	0.000759661484584085	0.000759661484584085	+1	PDGFRA,FGFR2,TGFBR2
GO:0070141	response to UV-A	0.000759661484584085	0.000759661484584085	+1	EGFR,AKT1,CCND1
GO:0048704	embryonic skeletal system morphogenesis	0.000765549827261433	0.000765549827261433	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:0043627	response to estrogen	0.000765549827261433	0.000765549827261433	+1	GATA3,AR,BRCA1,EP300
GO:0071559	response to transforming growth factor beta	0.0007752108222182128	0.0007752108222182128	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,SIN3A,SMAD2
GO:0060191	regulation of lipase activity	0.000784604508203654	0.000784604508203654	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0030518	intracellular steroid hormone receptor signaling pathway	0.0007862856982544417	0.0007862856982544417	+1	ARID1A,AR,BRCA1,FOXA1,EP300,NCOR1
GO:0006282	regulation of DNA repair	0.0007976542036815646	0.0007976542036815646	+1	ARID1A,PBRM1,EGFR,BRCA1,POLQ,SETD2,ATR,AXIN2
GO:0071241	cellular response to inorganic substance	0.0008213021767873417	0.0008213021767873417	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,ATRX,LRRK2
GO:0043401	steroid hormone mediated signaling pathway	0.000865780042946775	0.000865780042946775	+1	ARID1A,AR,BRCA1,FOXA1,EP300,NCOR1
GO:0001649	osteoblast differentiation	0.0008861142924016617	0.0008861142924016617	+1	NF1,NOTCH1,CTNNB1,SOX9,HGF,FGFR2,ACVR2A
GO:0009408	response to heat	0.0008907782565686055	0.0008907782565686055	+1	AKT1,ATM,MTOR,EP300,ATR
GO:0072073	kidney epithelium development	0.0008907782565686055	0.0008907782565686055	+1	GATA3,CTNNB1,SOX9,WT1,FGFR2
GO:0097695	establishment of protein-containing complex localization to telomere	0.000904733449247577	0.000904733449247577	+1	ATM,ATR
GO:0003249	cell proliferation involved in heart valve morphogenesis	0.000904733449247577	0.000904733449247577	+1	NOTCH1,SMAD4
GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis	0.000904733449247577	0.000904733449247577	+1	NOTCH1,TBX3
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	0.000904733449247577	0.000904733449247577	+1	GATA3,BRCA2
GO:0003250	regulation of cell proliferation involved in heart valve morphogenesis	0.000904733449247577	0.000904733449247577	+1	NOTCH1,SMAD4
GO:0097694	establishment of RNA localization to telomere	0.000904733449247577	0.000904733449247577	+1	ATM,ATR
GO:0042060	wound healing	0.000906854874384142	0.000906854874384142	+1	PIK3CA,PTEN,NF1,ARHGAP35,EPPK1,PIK3CG,MTOR,TLR4,PDGFRA,FOXA2
GO:0043068	positive regulation of programmed cell death	0.0009091542360956154	0.0009091542360956154	+1	TP53,APC,NF1,CDKN2A,NOTCH1,FBXW7,CTNNB1,ATM,TLR4,LRRK2,FOXA1
GO:0045662	negative regulation of myoblast differentiation	0.0009128482625646364	0.0009128482625646364	+1	NOTCH1,TBX3,SOX9
GO:0060045	positive regulation of cardiac muscle cell proliferation	0.0009128482625646364	0.0009128482625646364	+1	NOTCH1,ERBB4,FGFR2
GO:0010464	regulation of mesenchymal cell proliferation	0.0009128482625646364	0.0009128482625646364	+1	SOX9,FGFR2,TGFBR2
GO:0090068	positive regulation of cell cycle process	0.0009149038090657463	0.0009149038090657463	+1	EGFR,RB1,NPM1,AKT1,ATRX,CCND1,RAD21,EZH2
GO:0051225	spindle assembly	0.0009325301720110564	0.0009325301720110564	+1	PTEN,STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:0051641	cellular localization	0.0009368138554444745	0.0009368138554444745	+1	TP53,PIK3CA,PTEN,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,STK11,EPHA3,AKT1,BRAF,AR,PIK3CG,ATM,CDKN1B,MTOR,TLR4,ATRX,LRRK2,KIT,SETD2,EP300,FOXA2,USP9X,BRCA2,ATR,SIN3A,AXIN2,RAD21
GO:0045927	positive regulation of growth	0.0009698569955707212	0.0009698569955707212	+1	EGFR,NOTCH1,AKT1,WT1,ERBB4,MTOR,FGFR2
GO:0045814	negative regulation of gene expression, epigenetic	0.0009746254382956501	0.0009746254382956501	+1	RB1,DNMT3A,ATRX,BRCA1,SIN3A,EZH2
GO:0051438	regulation of ubiquitin-protein transferase activity	0.0010083729389366379	0.0010083729389366379	+1	PTEN,CDKN2A,FBXW7,RPL5
GO:0006739	NADP metabolic process	0.0010083729389366379	0.0010083729389366379	+1	TP53,IDH1,MTOR,IDH2
GO:0071396	cellular response to lipid	0.0010615419889103658	0.0010615419889103658	+1	ARID1A,EGFR,EPHA3,AR,SOX9,ATM,TLR4,BRCA1,FOXA1,EP300,NCOR1
GO:0000086	G2/M transition of mitotic cell cycle	0.001066311803199001	0.001066311803199001	+1	CDKN2A,ATM,BRCA1,CHEK2,CCND1,CDKN1A
GO:0051546	keratinocyte migration	0.0010991300288161656	0.0010991300288161656	+1	PTEN,EPPK1,MTOR
GO:0048485	sympathetic nervous system development	0.0010991300288161656	0.0010991300288161656	+1	NF1,GATA3,CTNNB1
GO:0031295	T cell costimulation	0.0011058411894285971	0.0011058411894285971	+1	PIK3CA,AKT1,MTOR,PTPN11
GO:0090090	negative regulation of canonical Wnt signaling pathway	0.001111221326043073	0.001111221326043073	+1	APC,STK11,SOX9,SMAD4,SOX17,AXIN2
GO:0040013	negative regulation of locomotion	0.001125021857850715	0.001125021857850715	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,SIN3A
GO:0006304	DNA modification	0.0011811542053477722	0.0011811542053477722	+1	DNMT3A,WT1,TET2,ATRX,USP9X
GO:1902106	negative regulation of leukocyte differentiation	0.0011811542053477722	0.0011811542053477722	+1	CDKN2A,FBXW7,RUNX1,TLR4,CBFB
GO:0003231	cardiac ventricle development	0.0011811542053477722	0.0011811542053477722	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:1900182	positive regulation of protein localization to nucleus	0.0011811542053477722	0.0011811542053477722	+1	PIK3R1,CDKN2A,CDH1,AKT1,EP300
GO:0032924	activin receptor signaling pathway	0.001197052956599228	0.001197052956599228	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
GO:0031648	protein destabilization	0.001197052956599228	0.001197052956599228	+1	CDKN2A,MTOR,EP300,SOX17
GO:0001657	ureteric bud development	0.001197052956599228	0.001197052956599228	+1	GATA3,SOX9,WT1,FGFR2
GO:1902116	negative regulation of organelle assembly	0.001197052956599228	0.001197052956599228	+1	AKT1,BRCA1,LRRK2,SMAD4
GO:0007405	neuroblast proliferation	0.001197052956599228	0.001197052956599228	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:2000027	regulation of animal organ morphogenesis	0.001197052956599228	0.001197052956599228	+1	GATA3,SOX9,WT1,HGF
GO:0051336	regulation of hydrolase activity	0.0012263568303336081	0.0012263568303336081	+1	EGFR,NF1,CDKN2A,NPM1,EPHA3,AKT1,MTOR,LRRK2,KIT,PDGFRA,FGFR2,FGFR3,EZH2
GO:0018107	peptidyl-threonine phosphorylation	0.0012423318827975102	0.0012423318827975102	+1	STK11,AKT1,LRRK2,TAF1,ACVR1B
GO:0097191	extrinsic apoptotic signaling pathway	0.0012630248312436936	0.0012630248312436936	+1	AKT1,AR,TLR4,BRCA1,SMAD4,FGFR3,ACVR1B
GO:0003002	regionalization	0.0012772491845776356	0.0012772491845776356	+1	NOTCH1,TBX3,WT1,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:1904031	positive regulation of cyclin-dependent protein kinase activity	0.0012870486020651595	0.0012870486020651595	+1	EGFR,AKT1,CCND1
GO:0071480	cellular response to gamma radiation	0.0012870486020651595	0.0012870486020651595	+1	TP53,ATM,ATR
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	0.0012870486020651595	0.0012870486020651595	+1	CDKN2A,ATM,ATR
GO:0045945	positive regulation of transcription by RNA polymerase III	0.0012870486020651595	0.0012870486020651595	+1	AR,MTOR,SF3B1
GO:0072164	mesonephric tubule development	0.0012928664626380563	0.0012928664626380563	+1	GATA3,SOX9,WT1,FGFR2
GO:0072163	mesonephric epithelium development	0.0012928664626380563	0.0012928664626380563	+1	GATA3,SOX9,WT1,FGFR2
GO:0031294	lymphocyte costimulation	0.0012928664626380563	0.0012928664626380563	+1	PIK3CA,AKT1,MTOR,PTPN11
GO:0046660	female sex differentiation	0.0012928664626380563	0.0012928664626380563	+1	TBX3,WT1,KIT,PDGFRA
GO:1903707	negative regulation of hemopoiesis	0.0013000050493442523	0.0013000050493442523	+1	CDKN2A,FBXW7,RUNX1,TLR4,CBFB
GO:0006260	DNA replication	0.0013366301062555674	0.0013366301062555674	+1	EGFR,ATRX,BRCA1,POLQ,BRCA2,PPP2R1A,ATR,SMC3
GO:0044089	positive regulation of cellular component biogenesis	0.0013555572170871196	0.0013555572170871196	+1	TP53,PIK3CA,APC,NAV3,PIK3R1,ARHGAP35,AJUBA,ATM,TLR4,SMAD4,ATR
GO:0045833	negative regulation of lipid metabolic process	0.0013751388812981644	0.0013751388812981644	+1	FBXW7,AKT1,SOX9,BRCA1,NCOR1
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	0.0014053553470074463	0.0014053553470074463	+1	CDKN2A,USP9X,TAF1,RPL5
GO:0007626	locomotory behavior	0.0014053553470074463	0.0014053553470074463	+1	PTEN,MTOR,FOXA2,NCOR1
GO:0044344	cellular response to fibroblast growth factor stimulus	0.001447163294651732	0.001447163294651732	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:1903321	negative regulation of protein modification by small protein conjugation or removal	0.001447163294651732	0.001447163294651732	+1	CDKN2A,CTNNB1,AKT1,TAF1,RPL5
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	0.001447163294651732	0.001447163294651732	+1	TP53,ATM,BRCA1,CHEK2,EP300
GO:0046822	regulation of nucleocytoplasmic transport	0.001447163294651732	0.001447163294651732	+1	PIK3R1,CDKN2A,CDH1,SETD2,EP300
GO:0071772	response to BMP	0.0014515249845380655	0.0014515249845380655	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0071773	cellular response to BMP stimulus	0.0014515249845380655	0.0014515249845380655	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0062009	secondary palate development	0.0014949836540712207	0.0014949836540712207	+1	SMAD4,TGFBR2,SMAD2
GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	0.0014949836540712207	0.0014949836540712207	+1	PTEN,CDKN1B,CDKN1A
GO:0055023	positive regulation of cardiac muscle tissue growth	0.0014949836540712207	0.0014949836540712207	+1	NOTCH1,ERBB4,FGFR2
GO:2001234	negative regulation of apoptotic signaling pathway	0.0015055486190469285	0.0015055486190469285	+1	RB1,NFE2L2,AKT1,AR,HGF,BRCA1,LRRK2
GO:0007179	transforming growth factor beta receptor signaling pathway	0.0015055486190469285	0.0015055486190469285	+1	STK11,EP300,SMAD4,USP9X,TGFBR2,SIN3A,SMAD2
GO:0030520	intracellular estrogen receptor signaling pathway	0.0015112949082793916	0.0015112949082793916	+1	ARID1A,AR,BRCA1,FOXA1
GO:0006289	nucleotide-excision repair	0.0015153574196470512	0.0015153574196470512	+1	TP53,ARID1A,PBRM1,BRCA2,ERCC2
GO:0000070	mitotic sister chromatid segregation	0.00155207961446078	0.00155207961446078	+1	APC,RB1,STAG2,ATM,CHEK2,SMC1A,SMC3
GO:0045862	positive regulation of proteolysis	0.0015554990192590543	0.0015554990192590543	+1	PTEN,CDKN2A,FBXW7,KEAP1,CEBPA,AKT1,LRRK2,TAF1,AXIN2
GO:1901874	negative regulation of post-translational protein modification	0.001596820581104434	0.001596820581104434	+1	CDKN2A,CTNNB1,AKT1,TAF1,RPL5
GO:0071774	response to fibroblast growth factor	0.001596820581104434	0.001596820581104434	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:0051345	positive regulation of hydrolase activity	0.0016116701147051047	0.0016116701147051047	+1	EGFR,NF1,CDKN2A,AKT1,MTOR,KIT,PDGFRA,FGFR2,FGFR3,EZH2
GO:0048873	homeostasis of number of cells within a tissue	0.0016168261430212765	0.0016168261430212765	+1	NOTCH1,SOX9
GO:0030916	otic vesicle formation	0.0016168261430212765	0.0016168261430212765	+1	SOX9,FGFR2
GO:0001889	liver development	0.0016168261430212765	0.0016168261430212765	+1	NF1,FBXW7,CEBPA,ARID5B
GO:2000793	cell proliferation involved in heart valve development	0.0016168261430212765	0.0016168261430212765	+1	NOTCH1,SMAD4
GO:0060445	branching involved in salivary gland morphogenesis	0.0016168261430212765	0.0016168261430212765	+1	HGF,FGFR2
GO:0060740	prostate gland epithelium morphogenesis	0.0016168261430212765	0.0016168261430212765	+1	SOX9,FGFR2
GO:0060736	prostate gland growth	0.0016168261430212765	0.0016168261430212765	+1	SOX9,FGFR2
GO:0048853	forebrain morphogenesis	0.0016168261430212765	0.0016168261430212765	+1	PTEN,NF1
GO:0071600	otic vesicle morphogenesis	0.0016168261430212765	0.0016168261430212765	+1	SOX9,FGFR2
GO:0003206	cardiac chamber morphogenesis	0.0016651342842918092	0.0016651342842918092	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0043009	chordate embryonic development	0.0016842615898228373	0.0016842615898228373	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:2000047	regulation of cell-cell adhesion mediated by cadherin	0.0017125857219683494	0.0017125857219683494	+1	NOTCH1,FOXA1,FOXA2
GO:1904666	regulation of ubiquitin protein ligase activity	0.0017125857219683494	0.0017125857219683494	+1	PTEN,CDKN2A,RPL5
GO:0030521	androgen receptor signaling pathway	0.0017307086219926222	0.0017307086219926222	+1	ARID1A,AR,EP300,NCOR1
GO:0061008	hepaticobiliary system development	0.0017307086219926222	0.0017307086219926222	+1	NF1,FBXW7,CEBPA,ARID5B
GO:0002011	morphogenesis of an epithelial sheet	0.0017307086219926222	0.0017307086219926222	+1	PTEN,NOTCH1,ARHGAP35,MTOR
GO:0044331	cell-cell adhesion mediated by cadherin	0.0017307086219926222	0.0017307086219926222	+1	NOTCH1,CDH1,FOXA1,FOXA2
GO:0001823	mesonephros development	0.0017307086219926222	0.0017307086219926222	+1	GATA3,SOX9,WT1,FGFR2
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	0.0017307086219926222	0.0017307086219926222	+1	NOTCH1,ERBB4,KIT,EP300
GO:0048709	oligodendrocyte differentiation	0.0017307086219926222	0.0017307086219926222	+1	PTEN,NF1,NOTCH1,SOX9
GO:0061448	connective tissue development	0.0017307086219926222	0.0017307086219926222	+1	RUNX1,SOX9,WT1,ARID5B,FGFR3,PTPN11
GO:0008286	insulin receptor signaling pathway	0.0017330592528776233	0.0017330592528776233	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0007417	central nervous system development	0.0017452718408263723	0.0017452718408263723	+1	PTEN,NF1,NOTCH1,CTNNB1,ARHGAP35,SOX9,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,SIN3A,PTPN11
GO:0051493	regulation of cytoskeleton organization	0.0017471149130512626	0.0017471149130512626	+1	PIK3CA,APC,NAV3,PIK3R1,ARHGAP35,NPM1,EPHA3,MTOR,BRCA1,PDGFRA,SMAD4
GO:0006109	regulation of carbohydrate metabolic process	0.0018575847274652946	0.0018575847274652946	+1	TP53,AKT1,MTOR,EP300,FOXA2,NCOR1
GO:0043470	regulation of carbohydrate catabolic process	0.001866003906241831	0.001866003906241831	+1	TP53,MTOR,EP300,NCOR1
GO:0001570	vasculogenesis	0.001866003906241831	0.001866003906241831	+1	NOTCH1,WT1,TGFBR2,SOX17
GO:1901653	cellular response to peptide	0.0019168467921217667	0.0019168467921217667	+1	TP53,PIK3CA,APC,PIK3R1,AKT1,MTOR,TLR4,PTPN11
GO:0010389	regulation of G2/M transition of mitotic cell cycle	0.0019173896292405909	0.0019173896292405909	+1	CDKN2A,ATM,BRCA1,CCND1,CDKN1A
GO:1902115	regulation of organelle assembly	0.0019387187403896889	0.0019387187403896889	+1	ARHGAP35,NPM1,AKT1,MTOR,BRCA1,LRRK2,SMAD4
GO:2001185	regulation of CD8-positive, alpha-beta T cell activation	0.0019480164078170834	0.0019480164078170834	+1	RUNX1,CBFB,MAPK8IP1
GO:0010463	mesenchymal cell proliferation	0.0019480164078170834	0.0019480164078170834	+1	SOX9,FGFR2,TGFBR2
GO:1905207	regulation of cardiocyte differentiation	0.0019480164078170834	0.0019480164078170834	+1	EGFR,SMAD4,SOX17
GO:0048806	genitalia development	0.0019480164078170834	0.0019480164078170834	+1	TBX3,WT1,PTPN11
GO:0010035	response to inorganic substance	0.001976839600907561	0.001976839600907561	+1	PIK3CA,EGFR,CDH1,NFE2L2,AKT1,BRAF,CDKN1B,ATRX,LRRK2
GO:0030071	regulation of mitotic metaphase/anaphase transition	0.0019867291971383313	0.0019867291971383313	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:0018210	peptidyl-threonine modification	0.0019867291971383313	0.0019867291971383313	+1	STK11,AKT1,LRRK2,TAF1,ACVR1B
GO:0062012	regulation of small molecule metabolic process	0.0019867291971383313	0.0019867291971383313	+1	TP53,AKT1,SOX9,MTOR,BRCA1,EP300,FOXA2,NCOR1
GO:0060411	cardiac septum morphogenesis	0.0019867291971383313	0.0019867291971383313	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0060993	kidney morphogenesis	0.0019867291971383313	0.0019867291971383313	+1	GATA3,SOX9,WT1,LRRK2
GO:0030336	negative regulation of cell migration	0.0019867291971383313	0.0019867291971383313	+1	PTEN,NAV3,NF1,NOTCH1,CDH1,AKT1,EPPK1,SIN3A
GO:0034605	cellular response to heat	0.0019867291971383313	0.0019867291971383313	+1	ATM,MTOR,EP300,ATR
GO:0120163	negative regulation of cold-induced thermogenesis	0.0019867291971383313	0.0019867291971383313	+1	RB1,NOTCH1,STK11,TLR4
GO:0010821	regulation of mitochondrion organization	0.002046164538359197	0.002046164538359197	+1	TP53,FBXW7,AKT1,HGF,LRRK2,EP300
GO:0060560	developmental growth involved in morphogenesis	0.0021261757025308656	0.0021261757025308656	+1	NOTCH1,CTNNB1,SOX9,FGFR2,USP9X,SIN3A
GO:0072080	nephron tubule development	0.0021261757025308656	0.0021261757025308656	+1	GATA3,CTNNB1,SOX9,WT1
GO:0010827	regulation of glucose transmembrane transport	0.0021261757025308656	0.0021261757025308656	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0071260	cellular response to mechanical stimulus	0.0021261757025308656	0.0021261757025308656	+1	MAP3K1,MAP2K4,SOX9,TLR4
GO:0048706	embryonic skeletal system development	0.0021261757025308656	0.0021261757025308656	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:1904894	positive regulation of receptor signaling pathway via STAT	0.0021261757025308656	0.0021261757025308656	+1	NOTCH1,ERBB4,KIT,EP300
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	0.0021834626840061015	0.0021834626840061015	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:1905477	positive regulation of protein localization to membrane	0.0021834626840061015	0.0021834626840061015	+1	PIK3CA,EGFR,PIK3R1,EPHA3,AKT1
GO:0043065	positive regulation of apoptotic process	0.0021973575626660097	0.0021973575626660097	+1	TP53,APC,NF1,CDKN2A,NOTCH1,FBXW7,CTNNB1,ATM,TLR4,FOXA1
GO:0007420	brain development	0.002239960169832733	0.002239960169832733	+1	PTEN,NF1,CTNNB1,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,SIN3A,PTPN11
GO:1903708	positive regulation of hemopoiesis	0.0022685789981818187	0.0022685789981818187	+1	ARID1A,PBRM1,GATA3,RUNX1,TGFBR2,CBFB
GO:1902107	positive regulation of leukocyte differentiation	0.0022685789981818187	0.0022685789981818187	+1	ARID1A,PBRM1,GATA3,RUNX1,TGFBR2,CBFB
GO:0061326	renal tubule development	0.00227153025038779	0.00227153025038779	+1	GATA3,CTNNB1,SOX9,WT1
GO:0032879	regulation of localization	0.00227153025038779	0.00227153025038779	+1	PIK3CA,PTEN,APC,EGFR,PIK3R1,CDKN2A,NOTCH1,FBXW7,CTNNB1,CDH1,BAP1,STK11,EPHA3,AKT1,BRAF,AR,MTOR,TLR4,LRRK2,SETD2,EP300,FOXA2,SIN3A,PTPN11
GO:0055006	cardiac cell development	0.00227153025038779	0.00227153025038779	+1	NOTCH1,TBX3,PDGFRA,SMAD4
GO:0097305	response to alcohol	0.002276471919642744	0.002276471919642744	+1	CTNNB1,CDH1,BRCA1,TGFBR2,SMAD2
GO:0070925	organelle assembly	0.002308917881898747	0.002308917881898747	+1	PTEN,NOTCH1,ARHGAP35,NPM1,AKT1,STAG2,MTOR,BRCA1,LRRK2,CHEK2,PDGFRA,SMAD4,SMC1A,SMC3,NCOR1,RPL5
GO:0072006	nephron development	0.0023873740241355285	0.0023873740241355285	+1	GATA3,CTNNB1,SOX9,WT1,PDGFRA
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	0.0023873740241355285	0.0023873740241355285	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:0019362	pyridine nucleotide metabolic process	0.0024232430207872316	0.0024232430207872316	+1	TP53,IDH1,MTOR,IDH2,EP300,NCOR1
GO:0046496	nicotinamide nucleotide metabolic process	0.0024232430207872316	0.0024232430207872316	+1	TP53,IDH1,MTOR,IDH2,EP300,NCOR1
GO:0032927	positive regulation of activin receptor signaling pathway	0.002454783421665712	0.002454783421665712	+1	ACVR1B,ACVR2A
GO:0003160	endocardium morphogenesis	0.002454783421665712	0.002454783421665712	+1	NOTCH1,SOX17
GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	0.002454783421665712	0.002454783421665712	+1	RUNX1,CBFB
GO:0071285	cellular response to lithium ion	0.002454783421665712	0.002454783421665712	+1	CDH1,CDKN1B
GO:0003149	membranous septum morphogenesis	0.002454783421665712	0.002454783421665712	+1	FGFR2,TGFBR2
GO:1901723	negative regulation of cell proliferation involved in kidney development	0.002454783421665712	0.002454783421665712	+1	GATA3,WT1
GO:0071481	cellular response to X-ray	0.002454783421665712	0.002454783421665712	+1	GATA3,ATM
GO:0060512	prostate gland morphogenesis	0.002454783421665712	0.002454783421665712	+1	SOX9,FGFR2
GO:2000435	negative regulation of protein neddylation	0.002454783421665712	0.002454783421665712	+1	CDKN2A,RPL5
GO:0006102	isocitrate metabolic process	0.002454783421665712	0.002454783421665712	+1	IDH1,IDH2
GO:0030539	male genitalia development	0.002454783421665712	0.002454783421665712	+1	TBX3,WT1
GO:0008637	apoptotic mitochondrial changes	0.0024611343031757885	0.0024611343031757885	+1	TP53,CDKN2A,AKT1,HGF,ERBB4
GO:0048546	digestive tract morphogenesis	0.0024611343031757885	0.0024611343031757885	+1	PDGFRA,FGFR2,SOX17
GO:1903432	regulation of TORC1 signaling	0.0024611343031757885	0.0024611343031757885	+1	VHL,STK11,AKT1,ATM,EP300
GO:0002684	positive regulation of immune system process	0.002461530923474188	0.002461530923474188	+1	PIK3CA,ARID1A,PBRM1,PIK3R1,GATA3,RUNX1,CEBPA,AKT1,MTOR,TLR4,KIT,EP300,TGFBR2,CBFB,SIN3A,PTPN11
GO:0032869	cellular response to insulin stimulus	0.0024641162866746863	0.0024641162866746863	+1	PIK3CA,APC,PIK3R1,AKT1,MTOR,PTPN11
GO:0007610	behavior	0.0024641162866746863	0.0024641162866746863	+1	TP53,PTEN,EGFR,NF1,MTOR,LRRK2,FOXA2,NCOR1
GO:0009792	embryo development ending in birth or egg hatching	0.0024859300937193625	0.0024859300937193625	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:0071248	cellular response to metal ion	0.0025498685822593517	0.0025498685822593517	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:0007254	JNK cascade	0.0025498685822593517	0.0025498685822593517	+1	EGFR,MAP2K4,LRRK2,MAPK8IP1,MECOM,NCOR1
GO:0043542	endothelial cell migration	0.0025505095290223067	0.0025505095290223067	+1	PIK3CA,NF1,GATA3,NOTCH1,AKT1,PIK3CG,EGR3
GO:2000379	positive regulation of reactive oxygen species metabolic process	0.0025505095290223067	0.0025505095290223067	+1	TP53,TLR4,TGFBR2,CDKN1A
GO:1903076	regulation of protein localization to plasma membrane	0.0025523584219274056	0.0025523584219274056	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0044784	metaphase/anaphase transition of cell cycle	0.0025523584219274056	0.0025523584219274056	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:0045667	regulation of osteoblast differentiation	0.0025523584219274056	0.0025523584219274056	+1	NOTCH1,SOX9,HGF,FGFR2,ACVR2A
GO:0050679	positive regulation of epithelial cell proliferation	0.0026279878536831585	0.0026279878536831585	+1	EGFR,NRAS,AKT1,SOX9,FGFR2,EGR3
GO:0010332	response to gamma radiation	0.002757864478669168	0.002757864478669168	+1	TP53,ATM,ATR
GO:0072210	metanephric nephron development	0.002757864478669168	0.002757864478669168	+1	SOX9,WT1,PDGFRA
GO:0003148	outflow tract septum morphogenesis	0.002757864478669168	0.002757864478669168	+1	FGFR2,SMAD4,TGFBR2
GO:0031668	cellular response to extracellular stimulus	0.002761966869791366	0.002761966869791366	+1	TP53,ARHGAP35,MTOR,LRRK2,EP300,FOXA2,CDKN1A
GO:0042592	homeostatic process	0.002761966869791366	0.002761966869791366	+1	APC,NF1,PIK3R1,RB1,NOTCH1,FBXW7,FLT3,NFE2L2,STK11,CEBPA,AKT1,SOX9,TLR4,LRRK2,KIT,SMAD4,FOXA2,PPP2R1A,ACVR1B,ACVR2A
GO:0045931	positive regulation of mitotic cell cycle	0.0027922027568415726	0.0027922027568415726	+1	EGFR,RB1,AKT1,FOXA1,CCND1
GO:0072524	pyridine-containing compound metabolic process	0.002799606196189481	0.002799606196189481	+1	TP53,IDH1,MTOR,IDH2,EP300,NCOR1
GO:1905475	regulation of protein localization to membrane	0.002799606196189481	0.002799606196189481	+1	PIK3CA,EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0071383	cellular response to steroid hormone stimulus	0.002799606196189481	0.002799606196189481	+1	ARID1A,AR,BRCA1,FOXA1,EP300,NCOR1
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	0.0028937369672489455	0.0028937369672489455	+1	FLT3,ERBB4,KIT,FGFR3
GO:0030178	negative regulation of Wnt signaling pathway	0.0028972227821757205	0.0028972227821757205	+1	APC,STK11,SOX9,SMAD4,SOX17,AXIN2
GO:0051169	nuclear transport	0.0029396633921791896	0.0029396633921791896	+1	PIK3R1,CDKN2A,CDH1,NPM1,AKT1,CDKN1B,SETD2,EP300
GO:0006913	nucleocytoplasmic transport	0.0029396633921791896	0.0029396633921791896	+1	PIK3R1,CDKN2A,CDH1,NPM1,AKT1,CDKN1B,SETD2,EP300
GO:0060322	head development	0.003003202179710066	0.003003202179710066	+1	PTEN,NF1,CTNNB1,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,SIN3A,PTPN11
GO:0003158	endothelium development	0.003040180942137392	0.003040180942137392	+1	NOTCH1,CTNNB1,SMAD4,SOX17,VEZF1
GO:1903055	positive regulation of extracellular matrix organization	0.0030670470015143237	0.0030670470015143237	+1	RB1,RUNX1,SMAD4
GO:0043525	positive regulation of neuron apoptotic process	0.0030670470015143237	0.0030670470015143237	+1	NF1,FBXW7,CTNNB1
GO:0003272	endocardial cushion formation	0.0030670470015143237	0.0030670470015143237	+1	NOTCH1,TBX3,TGFBR2
GO:1903078	positive regulation of protein localization to plasma membrane	0.0030670470015143237	0.0030670470015143237	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:0036037	CD8-positive, alpha-beta T cell activation	0.0030670470015143237	0.0030670470015143237	+1	RUNX1,CBFB,MAPK8IP1
GO:0060317	cardiac epithelial to mesenchymal transition	0.0030670470015143237	0.0030670470015143237	+1	NOTCH1,TBX3,TGFBR2
GO:0009611	response to wounding	0.0030906242064741296	0.0030906242064741296	+1	PIK3CA,PTEN,NF1,ARHGAP35,EPPK1,PIK3CG,MTOR,TLR4,PDGFRA,FOXA2
GO:0003205	cardiac chamber development	0.003156362041851101	0.003156362041851101	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0034660	ncRNA metabolic process	0.003174558195421706	0.003174558195421706	+1	TP53,EGFR,GATA3,AKT1,AR,SOX9,WT1,MTOR,FOXA1,NCOR1,RPL5,SMAD2
GO:0022408	negative regulation of cell-cell adhesion	0.003174558195421706	0.003174558195421706	+1	CDKN2A,NOTCH1,CDH1,RUNX1,AKT1,CBFB
GO:0060729	intestinal epithelial structure maintenance	0.0034045109234294327	0.0034045109234294327	+1	SOX9,TLR4
GO:1905941	positive regulation of gonad development	0.0034045109234294327	0.0034045109234294327	+1	SOX9,WT1
GO:0006305	DNA alkylation	0.0034045109234294327	0.0034045109234294327	+1	DNMT3A,WT1,ATRX
GO:0090394	negative regulation of excitatory postsynaptic potential	0.0034045109234294327	0.0034045109234294327	+1	PTEN,LRRK2
GO:0031509	subtelomeric heterochromatin formation	0.0034045109234294327	0.0034045109234294327	+1	ATRX,EZH2
GO:0090183	regulation of kidney development	0.0034045109234294327	0.0034045109234294327	+1	GATA3,SOX9,WT1
GO:0035270	endocrine system development	0.0034045109234294327	0.0034045109234294327	+1	NF1,AKT1,WT1,FOXA2
GO:0060602	branch elongation of an epithelium	0.0034045109234294327	0.0034045109234294327	+1	SOX9,FGFR2
GO:2000020	positive regulation of male gonad development	0.0034045109234294327	0.0034045109234294327	+1	SOX9,WT1
GO:0006306	DNA methylation	0.0034045109234294327	0.0034045109234294327	+1	DNMT3A,WT1,ATRX
GO:1904888	cranial skeletal system development	0.0034045109234294327	0.0034045109234294327	+1	PDGFRA,FGFR2,TGFBR2
GO:0048755	branching morphogenesis of a nerve	0.0034045109234294327	0.0034045109234294327	+1	LRRK2,FGFR2
GO:1902692	regulation of neuroblast proliferation	0.0034045109234294327	0.0034045109234294327	+1	NF1,CTNNB1,LRRK2
GO:0008340	determination of adult lifespan	0.0034045109234294327	0.0034045109234294327	+1	TP53,LRRK2
GO:0033045	regulation of sister chromatid segregation	0.0034045109234294327	0.0034045109234294327	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:1902498	regulation of protein autoubiquitination	0.0034045109234294327	0.0034045109234294327	+1	LRRK2,TAF1
GO:0071599	otic vesicle development	0.0034045109234294327	0.0034045109234294327	+1	SOX9,FGFR2
GO:0009798	axis specification	0.0034045109234294327	0.0034045109234294327	+1	TBX3,WT1,FOXA2,SMAD2
GO:1905323	telomerase holoenzyme complex assembly	0.0034045109234294327	0.0034045109234294327	+1	ATM,ATR
GO:0010226	response to lithium ion	0.0034045109234294327	0.0034045109234294327	+1	CDH1,CDKN1B
GO:0009266	response to temperature stimulus	0.0034045109234294327	0.0034045109234294327	+1	AKT1,ATM,MTOR,EP300,ATR
GO:0060348	bone development	0.0035226197167704406	0.0035226197167704406	+1	TP53,FBXW7,SOX9,FGFR2,FGFR3
GO:0032868	response to insulin	0.0035551042266672235	0.0035551042266672235	+1	PIK3CA,APC,PIK3R1,AKT1,MTOR,PTPN11
GO:1903051	negative regulation of proteolysis involved in protein catabolic process	0.003611036646460743	0.003611036646460743	+1	CDKN2A,USP9X,TAF1,RPL5
GO:0002062	chondrocyte differentiation	0.003611036646460743	0.003611036646460743	+1	RUNX1,SOX9,FGFR3,PTPN11
GO:0035924	cellular response to vascular endothelial growth factor stimulus	0.003611036646460743	0.003611036646460743	+1	PIK3CA,NOTCH1,PDGFRA,EGR3
GO:0048640	negative regulation of developmental growth	0.003611036646460743	0.003611036646460743	+1	PTEN,CDKN1B,FGFR3,CDKN1A
GO:0000902	cell morphogenesis	0.003718406160576449	0.003718406160576449	+1	PTEN,VHL,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,EPHA3,LRRK2,KIT,FGFR2,USP9X,SIN3A
GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus	0.0037359862499309828	0.0037359862499309828	+1	STK11,EP300,SMAD4
GO:0046326	positive regulation of glucose import	0.0037359862499309828	0.0037359862499309828	+1	PIK3R1,AKT1,PTPN11
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	0.0037359862499309828	0.0037359862499309828	+1	STK11,EP300,SMAD4
GO:0051150	regulation of smooth muscle cell differentiation	0.0037359862499309828	0.0037359862499309828	+1	NOTCH1,KIT,FGFR2
GO:0043254	regulation of protein-containing complex assembly	0.0037984176012354543	0.0037984176012354543	+1	TP53,NAV3,RB1,AJUBA,ATM,TLR4,EP300,ATR,PTPN11
GO:0048565	digestive tract development	0.003812242534291821	0.003812242534291821	+1	KIT,PDGFRA,FGFR2,SOX17
GO:0002244	hematopoietic progenitor cell differentiation	0.003812242534291821	0.003812242534291821	+1	TP53,NOTCH1,FLT3,KIT
GO:0035148	tube formation	0.003812242534291821	0.003812242534291821	+1	GATA3,NOTCH1,SOX9,FGFR2
GO:0007017	microtubule-based process	0.003875788041764151	0.003875788041764151	+1	PTEN,APC,NAV3,CTNNB1,NPM1,STK11,EPHA3,STAG2,BRCA1,CHEK2,SETD2,BRCA2,SMC1A,SMC3,NCOR1
GO:0033135	regulation of peptidyl-serine phosphorylation	0.0039521590855988355	0.0039521590855988355	+1	PTEN,EGFR,AKT1,BRAF,NSD1
GO:0032386	regulation of intracellular transport	0.003958719201246788	0.003958719201246788	+1	PIK3R1,CDKN2A,CDH1,STK11,LRRK2,SETD2,EP300
GO:0019221	cytokine-mediated signaling pathway	0.00395933987513645	0.00395933987513645	+1	TP53,PIK3R1,FLT3,CEBPA,AKT1,KIT,SMAD4,SIN3A,PTPN11,LIFR
GO:0048645	animal organ formation	0.004137774678014527	0.004137774678014527	+1	WT1,FGFR2,SOX17
GO:0048285	organelle fission	0.004241177165455633	0.004241177165455633	+1	PTEN,APC,RB1,STAG2,ATM,LRRK2,CHEK2,SMC1A,SMC3,RAD21
GO:0010720	positive regulation of cell development	0.004241177165455633	0.004241177165455633	+1	ARID1A,PBRM1,GATA3,NOTCH1,CTNNB1,RUNX1,TGFBR2,CBFB
GO:0009755	hormone-mediated signaling pathway	0.004249509021930718	0.004249509021930718	+1	ARID1A,AR,BRCA1,FOXA1,EP300,NCOR1
GO:0008543	fibroblast growth factor receptor signaling pathway	0.004268811831674899	0.004268811831674899	+1	GATA3,FGFR2,FGFR3,PTPN11
GO:0055123	digestive system development	0.004268811831674899	0.004268811831674899	+1	KIT,PDGFRA,FGFR2,SOX17
GO:2000736	regulation of stem cell differentiation	0.004268811831674899	0.004268811831674899	+1	NOTCH1,SOX9,PDGFRA,TGFBR2
GO:0002768	immune response-regulating cell surface receptor signaling pathway	0.004313891770590996	0.004313891770590996	+1	PIK3CA,PIK3R1,GATA3,MAP3K1,MAP2K4,TLR4,KIT,EP300
GO:0006275	regulation of DNA replication	0.00443611708310823	0.00443611708310823	+1	EGFR,ATRX,PPP2R1A,ATR,SMC3
GO:0034728	nucleosome organization	0.00443611708310823	0.00443611708310823	+1	ARID1A,NPM1,SOX9,ATRX,SETD2
GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	0.004517407105129951	0.004517407105129951	+1	BRCA1,FOXA1,EP300,NCOR1
GO:0048483	autonomic nervous system development	0.004523128960023493	0.004523128960023493	+1	NF1,GATA3,CTNNB1
GO:0043456	regulation of pentose-phosphate shunt	0.004523128960023493	0.004523128960023493	+1	TP53,MTOR
GO:0000578	embryonic axis specification	0.004523128960023493	0.004523128960023493	+1	TBX3,WT1,SMAD2
GO:2000018	regulation of male gonad development	0.004523128960023493	0.004523128960023493	+1	SOX9,WT1
GO:0071371	cellular response to gonadotropin stimulus	0.004523128960023493	0.004523128960023493	+1	NOTCH1,WT1
GO:0006359	regulation of transcription by RNA polymerase III	0.004523128960023493	0.004523128960023493	+1	AR,MTOR,SF3B1
GO:0007435	salivary gland morphogenesis	0.004523128960023493	0.004523128960023493	+1	HGF,FGFR2
GO:0065008	regulation of biological quality	0.004523128960023493	0.004523128960023493	+1	PIK3CA,PTEN,VHL,PIK3R1,CDKN2A,GATA3,FBXW7,TSHZ3,ARHGAP35,NPM1,TBX3,AKT1,PIK3CG,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,EP300,FOXA2,USP9X,SOX17,TAF1,SIN3A,RPL5,AXIN2
GO:0048715	negative regulation of oligodendrocyte differentiation	0.004523128960023493	0.004523128960023493	+1	NF1,NOTCH1
GO:0003190	atrioventricular valve formation	0.004523128960023493	0.004523128960023493	+1	NOTCH1,SMAD4
GO:1901798	positive regulation of signal transduction by p53 class mediator	0.004523128960023493	0.004523128960023493	+1	CDKN2A,ATM,ATR
GO:0045637	regulation of myeloid cell differentiation	0.0045819591779869846	0.0045819591779869846	+1	FBXW7,RUNX1,MTOR,TLR4,ACVR1B,ACVR2A
GO:0030900	forebrain development	0.0045819591779869846	0.0045819591779869846	+1	PTEN,NF1,ERBB4,LRRK2,FGFR2,SIN3A
GO:0048666	neuron development	0.0047167949535745265	0.0047167949535745265	+1	PTEN,PBRM1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,LRRK2,EP300,FGFR2,USP9X,SIN3A
GO:2000573	positive regulation of DNA biosynthetic process	0.0047167949535745265	0.0047167949535745265	+1	CTNNB1,ATM,HGF,ATR
GO:2001252	positive regulation of chromosome organization	0.004931985242240522	0.004931985242240522	+1	CTNNB1,ATM,ATRX,ATR,RAD21
GO:0042307	positive regulation of protein import into nucleus	0.004955815707778803	0.004955815707778803	+1	PIK3R1,CDH1,EP300
GO:0071542	dopaminergic neuron differentiation	0.004955815707778803	0.004955815707778803	+1	CTNNB1,FOXA1,FOXA2
GO:0072009	nephron epithelium development	0.004970201493608854	0.004970201493608854	+1	GATA3,CTNNB1,SOX9,WT1
GO:0032526	response to retinoic acid	0.004970201493608854	0.004970201493608854	+1	EPHA3,SOX9,ATM,ASXL1
GO:1904377	positive regulation of protein localization to cell periphery	0.004970201493608854	0.004970201493608854	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:0043467	regulation of generation of precursor metabolites and energy	0.005103315183216119	0.005103315183216119	+1	TP53,AKT1,MTOR,EP300,NCOR1
GO:0055007	cardiac muscle cell differentiation	0.005255218363688399	0.005255218363688399	+1	TBX3,WT1,PDGFRA,SMAD4
GO:1904375	regulation of protein localization to cell periphery	0.0052960286838923485	0.0052960286838923485	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0061041	regulation of wound healing	0.0052960286838923485	0.0052960286838923485	+1	PTEN,EPPK1,MTOR,PDGFRA,FOXA2
GO:0003006	developmental process involved in reproduction	0.005303179779313357	0.005303179779313357	+1	GATA3,DNMT3A,CTCF,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
GO:0031175	neuron projection development	0.005438112065944896	0.005438112065944896	+1	PTEN,PBRM1,RB1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,EP300,FGFR2,USP9X,SIN3A
GO:0048545	response to steroid hormone	0.005440199612538943	0.005440199612538943	+1	ARID1A,AR,BRCA1,FOXA1,EP300,NCOR1
GO:0071356	cellular response to tumor necrosis factor	0.005440199612538943	0.005440199612538943	+1	TP53,GATA3,NFE2L2,AKT1,BRCA1,LRRK2
GO:0090307	mitotic spindle assembly	0.005520664162524202	0.005520664162524202	+1	STAG2,CHEK2,SMC1A,SMC3
GO:1901652	response to peptide	0.005544379873794952	0.005544379873794952	+1	TP53,PIK3CA,APC,PIK3R1,AKT1,MTOR,TLR4,PTPN11
GO:0007431	salivary gland development	0.005794685612770971	0.005794685612770971	+1	HGF,FGFR2
GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation	0.005794685612770971	0.005794685612770971	+1	RUNX1,CBFB
GO:0034698	response to gonadotropin	0.005794685612770971	0.005794685612770971	+1	NOTCH1,WT1
GO:0060644	mammary gland epithelial cell differentiation	0.005794685612770971	0.005794685612770971	+1	AKT1,ERBB4
GO:0010839	negative regulation of keratinocyte proliferation	0.005794685612770971	0.005794685612770971	+1	EPPK1,FGFR2
GO:0090400	stress-induced premature senescence	0.005794685612770971	0.005794685612770971	+1	TP53,CDKN1A
GO:0072239	metanephric glomerulus vasculature development	0.005794685612770971	0.005794685612770971	+1	WT1,PDGFRA
GO:1905939	regulation of gonad development	0.005794685612770971	0.005794685612770971	+1	SOX9,WT1
GO:0033599	regulation of mammary gland epithelial cell proliferation	0.005794685612770971	0.005794685612770971	+1	GATA3,BRCA2
GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	0.005794685612770971	0.005794685612770971	+1	NOTCH1,TGFBR2
GO:0032071	regulation of endodeoxyribonuclease activity	0.005794685612770971	0.005794685612770971	+1	NPM1,AKT1
GO:0035520	monoubiquitinated protein deubiquitination	0.005794685612770971	0.005794685612770971	+1	BAP1,USP9X
GO:0007095	mitotic G2 DNA damage checkpoint signaling	0.005846786417661725	0.005846786417661725	+1	ATM,BRCA1,CDKN1A
GO:0060675	ureteric bud morphogenesis	0.005846786417661725	0.005846786417661725	+1	GATA3,SOX9,WT1
GO:0070198	protein localization to chromosome, telomeric region	0.005846786417661725	0.005846786417661725	+1	ATRX,BRCA2,ATR
GO:0045861	negative regulation of proteolysis	0.005846786417661725	0.005846786417661725	+1	CDKN2A,AKT1,LRRK2,USP9X,TAF1,RPL5
GO:0007162	negative regulation of cell adhesion	0.005922396389411622	0.005922396389411622	+1	PTEN,CDKN2A,NOTCH1,CDH1,RUNX1,AKT1,CBFB
GO:0072593	reactive oxygen species metabolic process	0.006012578595707527	0.006012578595707527	+1	TP53,TLR4,BRCA1,LRRK2,TGFBR2,CDKN1A
GO:0072594	establishment of protein localization to organelle	0.006082313185718366	0.006082313185718366	+1	PIK3R1,FBXW7,CDH1,BAP1,AKT1,LRRK2,EP300,USP9X,BRCA2
GO:0031214	biomineral tissue development	0.006254921445795514	0.006254921445795514	+1	NOTCH1,SOX9,FGFR2,FGFR3,ACVR2A
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	0.006254921445795514	0.006254921445795514	+1	PTEN,CDKN2A,FBXW7,BRCA1,LRRK2
GO:0031397	negative regulation of protein ubiquitination	0.006345939990590372	0.006345939990590372	+1	CDKN2A,AKT1,TAF1,RPL5
GO:0032206	positive regulation of telomere maintenance	0.006345939990590372	0.006345939990590372	+1	CTNNB1,ATM,ATRX,ATR
GO:0070741	response to interleukin-6	0.0063603965117948955	0.0063603965117948955	+1	CEBPA,SMAD4,FOXA2
GO:1901875	positive regulation of post-translational protein modification	0.006456916920732981	0.006456916920732981	+1	PTEN,CDKN2A,FBXW7,BRCA1,LRRK2
GO:0030198	extracellular matrix organization	0.006456916920732981	0.006456916920732981	+1	NF1,RB1,NOTCH1,RUNX1,WT1,SMAD4,AXIN2
GO:0070661	leukocyte proliferation	0.006456916920732981	0.006456916920732981	+1	CDKN2A,FLT3,PIK3CG,ATM,KIT,TGFBR2,MAPK8IP1
GO:0030509	BMP signaling pathway	0.006456916920732981	0.006456916920732981	+1	NOTCH1,SMAD4,USP9X,ACVR2A,SMAD2
GO:0031334	positive regulation of protein-containing complex assembly	0.006495917857721211	0.006495917857721211	+1	TP53,NAV3,AJUBA,ATM,TLR4,ATR
GO:0043062	extracellular structure organization	0.0066011518815182494	0.0066011518815182494	+1	NF1,RB1,NOTCH1,RUNX1,WT1,SMAD4,AXIN2
GO:0032008	positive regulation of TOR signaling	0.006622643080827723	0.006622643080827723	+1	PIK3CA,AKT1,EP300,USP9X
GO:1901992	positive regulation of mitotic cell cycle phase transition	0.006622643080827723	0.006622643080827723	+1	EGFR,RB1,AKT1,CCND1
GO:0060395	SMAD protein signal transduction	0.006622643080827723	0.006622643080827723	+1	SMAD4,TGFBR2,ACVR2A,SMAD2
GO:0010001	glial cell differentiation	0.006653253906863587	0.006653253906863587	+1	PTEN,NF1,NOTCH1,SOX9,PRX
GO:0000280	nuclear division	0.00667519633013191	0.00667519633013191	+1	PTEN,APC,RB1,STAG2,ATM,CHEK2,SMC1A,SMC3,RAD21
GO:0045229	external encapsulating structure organization	0.0067193301168268155	0.0067193301168268155	+1	NF1,RB1,NOTCH1,RUNX1,WT1,SMAD4,AXIN2
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.006842939501243666	0.006842939501243666	+1	FBXW7,NFE2L2,AKT1
GO:0032212	positive regulation of telomere maintenance via telomerase	0.006842939501243666	0.006842939501243666	+1	CTNNB1,ATM,ATR
GO:0072171	mesonephric tubule morphogenesis	0.006842939501243666	0.006842939501243666	+1	GATA3,SOX9,WT1
GO:0035850	epithelial cell differentiation involved in kidney development	0.006842939501243666	0.006842939501243666	+1	GATA3,CTNNB1,WT1
GO:0048667	cell morphogenesis involved in neuron differentiation	0.006871229899743797	0.006871229899743797	+1	PTEN,RB1,NOTCH1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A
GO:0007267	cell-cell signaling	0.006871229899743797	0.006871229899743797	+1	PTEN,APC,EGFR,CTNNB1,TSHZ3,TBX3,STK11,AKT1,AR,SOX9,HGF,LRRK2,FGFR2,SMAD4,FOXA2,SOX17,PPP2R1A,TBL1XR1,AXIN2
GO:1900542	regulation of purine nucleotide metabolic process	0.0068990797965711986	0.0068990797965711986	+1	TP53,MTOR,EP300,NCOR1
GO:0021953	central nervous system neuron differentiation	0.0068990797965711986	0.0068990797965711986	+1	PTEN,ARHGAP35,FGFR2,SIN3A
GO:0007051	spindle organization	0.00696950774669764	0.00696950774669764	+1	PTEN,STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:0034504	protein localization to nucleus	0.0069747647750105415	0.0069747647750105415	+1	PIK3R1,CDKN2A,CDH1,AKT1,MTOR,EP300,SIN3A
GO:0072079	nephron tubule formation	0.007013274120864092	0.007013274120864092	+1	GATA3,SOX9
GO:0003376	sphingosine-1-phosphate receptor signaling pathway	0.007013274120864092	0.007013274120864092	+1	AKT1,PIK3CG
GO:1903689	regulation of wound healing, spreading of epidermal cells	0.007013274120864092	0.007013274120864092	+1	PTEN,MTOR
GO:0003416	endochondral bone growth	0.007013274120864092	0.007013274120864092	+1	SOX9,FGFR3
GO:1905208	negative regulation of cardiocyte differentiation	0.007013274120864092	0.007013274120864092	+1	EGFR,SMAD4
GO:0048557	embryonic digestive tract morphogenesis	0.007013274120864092	0.007013274120864092	+1	PDGFRA,FGFR2
GO:0002327	immature B cell differentiation	0.007013274120864092	0.007013274120864092	+1	ATM,KIT
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	0.007013274120864092	0.007013274120864092	+1	FOXA1,FOXA2
GO:0002328	pro-B cell differentiation	0.007013274120864092	0.007013274120864092	+1	NOTCH1,FLT3
GO:0140719	constitutive heterochromatin formation	0.007013274120864092	0.007013274120864092	+1	ATRX,EZH2
GO:0090520	sphingolipid mediated signaling pathway	0.007013274120864092	0.007013274120864092	+1	AKT1,PIK3CG
GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	0.007013274120864092	0.007013274120864092	+1	RUNX1,CBFB
GO:0062042	regulation of cardiac epithelial to mesenchymal transition	0.007013274120864092	0.007013274120864092	+1	NOTCH1,TGFBR2
GO:0060443	mammary gland morphogenesis	0.007013274120864092	0.007013274120864092	+1	ELF3,FGFR2
GO:0046322	negative regulation of fatty acid oxidation	0.007013274120864092	0.007013274120864092	+1	AKT1,SOX9
GO:0032101	regulation of response to external stimulus	0.007013274120864092	0.007013274120864092	+1	PTEN,PIK3R1,GATA3,RB1,NOTCH1,NFE2L2,CEBPA,AKT1,EPPK1,TLR4,PDGFRA,EP300,FOXA2,SIN3A,PTPN11
GO:1901722	regulation of cell proliferation involved in kidney development	0.007013274120864092	0.007013274120864092	+1	GATA3,WT1
GO:1902031	regulation of NADP metabolic process	0.007013274120864092	0.007013274120864092	+1	TP53,MTOR
GO:0060911	cardiac cell fate commitment	0.007013274120864092	0.007013274120864092	+1	WT1,SOX17
GO:0043583	ear development	0.0070868829226067	0.0070868829226067	+1	GATA3,SOX9,FGFR2,PTPN11
GO:0019217	regulation of fatty acid metabolic process	0.0070868829226067	0.0070868829226067	+1	AKT1,SOX9,BRCA1,NCOR1
GO:0006140	regulation of nucleotide metabolic process	0.0070868829226067	0.0070868829226067	+1	TP53,MTOR,EP300,NCOR1
GO:0044319	wound healing, spreading of cells	0.007208676611859444	0.007208676611859444	+1	PTEN,ARHGAP35,MTOR
GO:0010863	positive regulation of phospholipase C activity	0.007208676611859444	0.007208676611859444	+1	EGFR,KIT,PDGFRA
GO:0055010	ventricular cardiac muscle tissue morphogenesis	0.007208676611859444	0.007208676611859444	+1	NOTCH1,FGFR2,SMAD4
GO:0032355	response to estradiol	0.007208676611859444	0.007208676611859444	+1	EGFR,CTNNB1,FOXA1
GO:0060391	positive regulation of SMAD protein signal transduction	0.007208676611859444	0.007208676611859444	+1	SMAD4,TGFBR2,ACVR2A
GO:0090505	epiboly involved in wound healing	0.007208676611859444	0.007208676611859444	+1	PTEN,ARHGAP35,MTOR
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.007377458759332071	0.007377458759332071	+1	STK11,EP300,SMAD4,SIN3A,SMAD2
GO:0046631	alpha-beta T cell activation	0.007377458759332071	0.007377458759332071	+1	GATA3,RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:0032989	cellular anatomical entity morphogenesis	0.007611205287012119	0.007611205287012119	+1	PTEN,NOTCH1,CTNNB1,ARHGAP35,EPHA3,LRRK2,PDGFRA,FGFR2,SMAD4,USP9X,SIN3A
GO:0051099	positive regulation of binding	0.0076309122387574375	0.0076309122387574375	+1	GATA3,RB1,LRRK2,USP9X,TAF1
GO:0090504	epiboly	0.0077723443456982925	0.0077723443456982925	+1	PTEN,ARHGAP35,MTOR
GO:0045581	negative regulation of T cell differentiation	0.0077723443456982925	0.0077723443456982925	+1	CDKN2A,RUNX1,CBFB
GO:0046638	positive regulation of alpha-beta T cell differentiation	0.0077723443456982925	0.0077723443456982925	+1	RUNX1,TGFBR2,CBFB
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	0.0077723443456982925	0.0077723443456982925	+1	CDKN2A,ATM,ATR
GO:0046329	negative regulation of JNK cascade	0.0077723443456982925	0.0077723443456982925	+1	MAPK8IP1,MECOM,NCOR1
GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	0.007850884375250968	0.007850884375250968	+1	STK11,EP300,SMAD4,SIN3A,SMAD2
GO:0051983	regulation of chromosome segregation	0.007850884375250968	0.007850884375250968	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:0034612	response to tumor necrosis factor	0.007914974239804307	0.007914974239804307	+1	TP53,GATA3,NFE2L2,AKT1,BRCA1,LRRK2
GO:0051053	negative regulation of DNA metabolic process	0.008115261783219276	0.008115261783219276	+1	TP53,ATM,POLQ,CDKN1A,ATR
GO:0065004	protein-DNA complex assembly	0.008119597915283647	0.008119597915283647	+1	TP53,RB1,NPM1,SOX9,ATRX,TAF1
GO:0045815	transcription initiation-coupled chromatin remodeling	0.008341396784519978	0.008341396784519978	+1	TP53,ARID1A,EP300
GO:0070673	response to interleukin-18	0.008341396784519978	0.008341396784519978	+1	PIK3R1,AKT1
GO:2000677	regulation of transcription regulatory region DNA binding	0.008341396784519978	0.008341396784519978	+1	GATA3,RB1,NSD1
GO:2000739	regulation of mesenchymal stem cell differentiation	0.008341396784519978	0.008341396784519978	+1	SOX9,PDGFRA
GO:0008585	female gonad development	0.008341396784519978	0.008341396784519978	+1	WT1,KIT,PDGFRA
GO:0033598	mammary gland epithelial cell proliferation	0.008341396784519978	0.008341396784519978	+1	GATA3,BRCA2
GO:0071351	cellular response to interleukin-18	0.008341396784519978	0.008341396784519978	+1	PIK3R1,AKT1
GO:1900274	regulation of phospholipase C activity	0.008341396784519978	0.008341396784519978	+1	EGFR,KIT,PDGFRA
GO:0043217	myelin maintenance	0.008341396784519978	0.008341396784519978	+1	PTEN,PRX
GO:1904667	negative regulation of ubiquitin protein ligase activity	0.008341396784519978	0.008341396784519978	+1	CDKN2A,RPL5
GO:0009948	anterior/posterior axis specification	0.008341396784519978	0.008341396784519978	+1	TBX3,WT1,FOXA2
GO:0042692	muscle cell differentiation	0.008341396784519978	0.008341396784519978	+1	NOTCH1,TBX3,WT1,KIT,PDGFRA,FGFR2,SMAD4
GO:0003183	mitral valve morphogenesis	0.008341396784519978	0.008341396784519978	+1	NOTCH1,AXIN2
GO:0051865	protein autoubiquitination	0.008341396784519978	0.008341396784519978	+1	BRCA1,LRRK2,BRCA2,TAF1
GO:0072182	regulation of nephron tubule epithelial cell differentiation	0.008341396784519978	0.008341396784519978	+1	GATA3,CTNNB1
GO:0035655	interleukin-18-mediated signaling pathway	0.008341396784519978	0.008341396784519978	+1	PIK3R1,AKT1
GO:0032070	regulation of deoxyribonuclease activity	0.008341396784519978	0.008341396784519978	+1	NPM1,AKT1
GO:0003401	axis elongation	0.008341396784519978	0.008341396784519978	+1	SOX9,FGFR2
GO:0030850	prostate gland development	0.008341396784519978	0.008341396784519978	+1	SOX9,FGFR2
GO:1904659	glucose transmembrane transport	0.008341396784519978	0.008341396784519978	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0060039	pericardium development	0.008341396784519978	0.008341396784519978	+1	NOTCH1,WT1
GO:1904358	positive regulation of telomere maintenance via telomere lengthening	0.008341396784519978	0.008341396784519978	+1	CTNNB1,ATM,ATR
GO:0140014	mitotic nuclear division	0.008421935944814152	0.008421935944814152	+1	APC,RB1,STAG2,ATM,CHEK2,SMC1A,SMC3
GO:0031669	cellular response to nutrient levels	0.008602617535659336	0.008602617535659336	+1	TP53,MTOR,LRRK2,EP300,FOXA2,CDKN1A
GO:0070201	regulation of establishment of protein localization	0.00875613162003555	0.00875613162003555	+1	PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,TLR4,LRRK2,EP300,FOXA2
GO:0046324	regulation of glucose import	0.00881224336114929	0.00881224336114929	+1	PIK3R1,AKT1,PTPN11
GO:0046545	development of primary female sexual characteristics	0.00881224336114929	0.00881224336114929	+1	WT1,KIT,PDGFRA
GO:0060021	roof of mouth development	0.00881224336114929	0.00881224336114929	+1	SMAD4,TGFBR2,SMAD2
GO:0141137	positive regulation of gene expression, epigenetic	0.00881224336114929	0.00881224336114929	+1	TP53,ARID1A,EP300
GO:0061005	cell differentiation involved in kidney development	0.00881224336114929	0.00881224336114929	+1	GATA3,CTNNB1,WT1
GO:0072078	nephron tubule morphogenesis	0.00881224336114929	0.00881224336114929	+1	GATA3,SOX9,WT1
GO:1902904	negative regulation of supramolecular fiber organization	0.009002976653357316	0.009002976653357316	+1	PIK3CA,APC,NAV3,PIK3R1,SMAD4
GO:2000779	regulation of double-strand break repair	0.009002976653357316	0.009002976653357316	+1	ARID1A,PBRM1,POLQ,SETD2,ATR
GO:0090287	regulation of cellular response to growth factor stimulus	0.009107201537886243	0.009107201537886243	+1	GATA3,NOTCH1,STK11,EP300,SMAD4,SIN3A,SMAD2
GO:1905330	regulation of morphogenesis of an epithelium	0.00947165362427582	0.00947165362427582	+1	GATA3,SOX9,HGF
GO:0048662	negative regulation of smooth muscle cell proliferation	0.00947165362427582	0.00947165362427582	+1	PTEN,CDKN1B,CDKN1A
GO:1903034	regulation of response to wounding	0.009587307573151568	0.009587307573151568	+1	PTEN,EPPK1,MTOR,PDGFRA,FOXA2
GO:0061351	neural precursor cell proliferation	0.009803997298185256	0.009803997298185256	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:0008645	hexose transmembrane transport	0.009803997298185256	0.009803997298185256	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0045446	endothelial cell differentiation	0.009803997298185256	0.009803997298185256	+1	NOTCH1,SMAD4,SOX17,VEZF1
GO:0048639	positive regulation of developmental growth	0.009803997298185256	0.009803997298185256	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0030278	regulation of ossification	0.009803997298185256	0.009803997298185256	+1	NOTCH1,SOX9,PTPN11,ACVR2A
GO:0046606	negative regulation of centrosome cycle	0.009867218091444205	0.009867218091444205	+1	NPM1,BRCA1
GO:0098868	bone growth	0.009867218091444205	0.009867218091444205	+1	SOX9,FGFR3
GO:1900037	regulation of cellular response to hypoxia	0.009867218091444205	0.009867218091444205	+1	VHL,AJUBA
GO:0043374	CD8-positive, alpha-beta T cell differentiation	0.009867218091444205	0.009867218091444205	+1	RUNX1,CBFB
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	0.009867218091444205	0.009867218091444205	+1	NOTCH1,TGFBR2
GO:0003174	mitral valve development	0.009867218091444205	0.009867218091444205	+1	NOTCH1,AXIN2
GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	0.009867218091444205	0.009867218091444205	+1	AKT1,TLR4
GO:0030325	adrenal gland development	0.009867218091444205	0.009867218091444205	+1	NF1,WT1
GO:0010826	negative regulation of centrosome duplication	0.009867218091444205	0.009867218091444205	+1	NPM1,BRCA1
GO:0072028	nephron morphogenesis	0.010004711690555008	0.010004711690555008	+1	GATA3,SOX9,WT1
GO:0021954	central nervous system neuron development	0.010004711690555008	0.010004711690555008	+1	PTEN,ARHGAP35,FGFR2
GO:0042306	regulation of protein import into nucleus	0.010004711690555008	0.010004711690555008	+1	PIK3R1,CDH1,EP300
GO:0072088	nephron epithelium morphogenesis	0.010004711690555008	0.010004711690555008	+1	GATA3,SOX9,WT1
GO:0060349	bone morphogenesis	0.010004711690555008	0.010004711690555008	+1	SOX9,FGFR2,FGFR3
GO:0051145	smooth muscle cell differentiation	0.010004711690555008	0.010004711690555008	+1	NOTCH1,KIT,FGFR2
GO:0097435	supramolecular fiber organization	0.010269859595049672	0.010269859595049672	+1	PIK3CA,APC,VHL,NAV3,NF1,PIK3R1,CDKN2A,RB1,ARHGAP35,EPPK1,PDGFRA,SMAD4,USP9X
GO:0007368	determination of left/right symmetry	0.0105213763056761	0.0105213763056761	+1	NOTCH1,TGFBR2,SOX17,SMAD2
GO:0046634	regulation of alpha-beta T cell activation	0.0105213763056761	0.0105213763056761	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:0046632	alpha-beta T cell differentiation	0.0105213763056761	0.0105213763056761	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0015749	monosaccharide transmembrane transport	0.0105213763056761	0.0105213763056761	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:1990874	vascular associated smooth muscle cell proliferation	0.010618863718340085	0.010618863718340085	+1	PTEN,CDKN1B,CDKN1A
GO:1903214	regulation of protein targeting to mitochondrion	0.010618863718340085	0.010618863718340085	+1	FBXW7,BAP1,LRRK2
GO:0048844	artery morphogenesis	0.010618863718340085	0.010618863718340085	+1	NF1,NOTCH1,TGFBR2
GO:1904705	regulation of vascular associated smooth muscle cell proliferation	0.010618863718340085	0.010618863718340085	+1	PTEN,CDKN1B,CDKN1A
GO:0003229	ventricular cardiac muscle tissue development	0.010618863718340085	0.010618863718340085	+1	NOTCH1,FGFR2,SMAD4
GO:0045620	negative regulation of lymphocyte differentiation	0.010618863718340085	0.010618863718340085	+1	CDKN2A,RUNX1,CBFB
GO:0043393	regulation of protein binding	0.010618863718340085	0.010618863718340085	+1	AKT1,LRRK2,USP9X,CDKN1A,TAF1
GO:0010634	positive regulation of epithelial cell migration	0.010618863718340085	0.010618863718340085	+1	GATA3,AKT1,PIK3CG,SOX9,MTOR
GO:0061333	renal tubule morphogenesis	0.010618863718340085	0.010618863718340085	+1	GATA3,SOX9,WT1
GO:0060972	left/right pattern formation	0.010890811889013552	0.010890811889013552	+1	NOTCH1,TGFBR2,SOX17,SMAD2
GO:0071375	cellular response to peptide hormone stimulus	0.01119869220595129	0.01119869220595129	+1	PIK3CA,APC,PIK3R1,AKT1,MTOR,PTPN11
GO:2001242	regulation of intrinsic apoptotic signaling pathway	0.011230154150375055	0.011230154150375055	+1	TP53,FBXW7,NFE2L2,AKT1,LRRK2
GO:1990000	amyloid fibril formation	0.01128157411857635	0.01128157411857635	+1	VHL,CDKN2A,USP9X
GO:0030811	regulation of nucleotide catabolic process	0.01128157411857635	0.01128157411857635	+1	MTOR,EP300,NCOR1
GO:0140467	integrated stress response signaling	0.01128157411857635	0.01128157411857635	+1	NFE2L2,CEBPA,NFE2L3
GO:0090199	regulation of release of cytochrome c from mitochondria	0.01128157411857635	0.01128157411857635	+1	TP53,AKT1,HGF
GO:0006984	ER-nucleus signaling pathway	0.01128157411857635	0.01128157411857635	+1	TP53,FBXW7,NFE2L2
GO:0045912	negative regulation of carbohydrate metabolic process	0.01128157411857635	0.01128157411857635	+1	EP300,FOXA2,NCOR1
GO:0006110	regulation of glycolytic process	0.01128157411857635	0.01128157411857635	+1	MTOR,EP300,NCOR1
GO:0033121	regulation of purine nucleotide catabolic process	0.01128157411857635	0.01128157411857635	+1	MTOR,EP300,NCOR1
GO:0051152	positive regulation of smooth muscle cell differentiation	0.011301396444989766	0.011301396444989766	+1	NOTCH1,KIT
GO:0035988	chondrocyte proliferation	0.011301396444989766	0.011301396444989766	+1	SOX9,FGFR3
GO:2000696	regulation of epithelial cell differentiation involved in kidney development	0.011301396444989766	0.011301396444989766	+1	GATA3,CTNNB1
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	0.011301396444989766	0.011301396444989766	+1	PIK3CA,PIK3CG
GO:0072224	metanephric glomerulus development	0.011301396444989766	0.011301396444989766	+1	WT1,PDGFRA
GO:0071233	cellular response to leucine	0.011301396444989766	0.011301396444989766	+1	MTOR,EP300
GO:0030889	negative regulation of B cell proliferation	0.011301396444989766	0.011301396444989766	+1	CDKN2A,ATM
GO:0071493	cellular response to UV-B	0.011301396444989766	0.011301396444989766	+1	STK11,CDKN1A
GO:0045686	negative regulation of glial cell differentiation	0.011301396444989766	0.011301396444989766	+1	NF1,NOTCH1
GO:0043201	response to leucine	0.011301396444989766	0.011301396444989766	+1	MTOR,EP300
GO:0060231	mesenchymal to epithelial transition	0.011301396444989766	0.011301396444989766	+1	GATA3,WT1
GO:0035272	exocrine system development	0.011301396444989766	0.011301396444989766	+1	HGF,FGFR2
GO:0007530	sex determination	0.011301396444989766	0.011301396444989766	+1	SOX9,WT1
GO:0072160	nephron tubule epithelial cell differentiation	0.011301396444989766	0.011301396444989766	+1	GATA3,CTNNB1
GO:0035710	CD4-positive, alpha-beta T cell activation	0.011598149508518176	0.011598149508518176	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0001947	heart looping	0.011899150773438564	0.011899150773438564	+1	NOTCH1,TGFBR2,SOX17
GO:1903747	regulation of establishment of protein localization to mitochondrion	0.011899150773438564	0.011899150773438564	+1	FBXW7,BAP1,LRRK2
GO:0090263	positive regulation of canonical Wnt signaling pathway	0.012064047084298417	0.012064047084298417	+1	EGFR,LRRK2,FGFR2,TBL1XR1
GO:0006508	proteolysis	0.012492066011522028	0.012492066011522028	+1	PTEN,APC,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,RUNX1,CEBPA,AKT1,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP,AXIN2
GO:0007422	peripheral nervous system development	0.01266722247857585	0.01266722247857585	+1	NF1,RUNX1,PRX
GO:0071229	cellular response to acid chemical	0.01266722247857585	0.01266722247857585	+1	PIK3CA,MTOR,EP300
GO:0055008	cardiac muscle tissue morphogenesis	0.01266722247857585	0.01266722247857585	+1	NOTCH1,FGFR2,SMAD4
GO:0032956	regulation of actin cytoskeleton organization	0.012958794170999356	0.012958794170999356	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,MTOR,PDGFRA,SMAD4
GO:0022011	myelination in peripheral nervous system	0.012985474414930007	0.012985474414930007	+1	NF1,PRX
GO:0072350	tricarboxylic acid metabolic process	0.012985474414930007	0.012985474414930007	+1	IDH1,IDH2
GO:0010614	negative regulation of cardiac muscle hypertrophy	0.012985474414930007	0.012985474414930007	+1	NOTCH1,SMAD4
GO:0070314	G1 to G0 transition	0.012985474414930007	0.012985474414930007	+1	TP53,STK11
GO:0003188	heart valve formation	0.012985474414930007	0.012985474414930007	+1	NOTCH1,SMAD4
GO:0032292	peripheral nervous system axon ensheathment	0.012985474414930007	0.012985474414930007	+1	NF1,PRX
GO:0014044	Schwann cell development	0.012985474414930007	0.012985474414930007	+1	NF1,PRX
GO:0010165	response to X-ray	0.012985474414930007	0.012985474414930007	+1	GATA3,ATM
GO:0106030	neuron projection fasciculation	0.012985474414930007	0.012985474414930007	+1	ARHGAP35,EPHA3
GO:0007413	axonal fasciculation	0.012985474414930007	0.012985474414930007	+1	ARHGAP35,EPHA3
GO:0034086	maintenance of sister chromatid cohesion	0.012985474414930007	0.012985474414930007	+1	RB1,ATRX
GO:0034088	maintenance of mitotic sister chromatid cohesion	0.012985474414930007	0.012985474414930007	+1	RB1,ATRX
GO:0002761	regulation of myeloid leukocyte differentiation	0.012985474414930007	0.012985474414930007	+1	FBXW7,RUNX1,MTOR,TLR4
GO:0014741	negative regulation of muscle hypertrophy	0.012985474414930007	0.012985474414930007	+1	NOTCH1,SMAD4
GO:0002764	immune response-regulating signaling pathway	0.012985474414930007	0.012985474414930007	+1	PIK3CA,PIK3R1,GATA3,MAP3K1,MAP2K4,AKT1,TLR4,KIT,EP300
GO:0021772	olfactory bulb development	0.012985474414930007	0.012985474414930007	+1	ERBB4,LRRK2
GO:0072273	metanephric nephron morphogenesis	0.012985474414930007	0.012985474414930007	+1	SOX9,WT1
GO:0009991	response to extracellular stimulus	0.013007654761749346	0.013007654761749346	+1	TP53,ARHGAP35,MTOR,LRRK2,EP300,FOXA2,CDKN1A
GO:0071300	cellular response to retinoic acid	0.013269837461849412	0.013269837461849412	+1	EPHA3,SOX9,ATM
GO:0001776	leukocyte homeostasis	0.013269837461849412	0.013269837461849412	+1	FLT3,AKT1,PPP2R1A
GO:0046651	lymphocyte proliferation	0.013269837461849412	0.013269837461849412	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:0009799	specification of symmetry	0.013305133203898027	0.013305133203898027	+1	NOTCH1,TGFBR2,SOX17,SMAD2
GO:0009855	determination of bilateral symmetry	0.013305133203898027	0.013305133203898027	+1	NOTCH1,TGFBR2,SOX17,SMAD2
GO:0007423	sensory organ development	0.013460329075981737	0.013460329075981737	+1	NF1,GATA3,SOX9,WT1,PDGFRA,FGFR2,PTPN11
GO:0043414	macromolecule methylation	0.01360195122492707	0.01360195122492707	+1	DNMT3A,AKT1,WT1,ATRX,SETD2
GO:0065003	protein-containing complex assembly	0.013610836397346325	0.013610836397346325	+1	TP53,APC,NAV3,RB1,NPM1,AJUBA,SOX9,ATM,TLR4,ATRX,LRRK2,POLQ,EP300,SF3B1,TAF1,PPP2R1A,ATR,PTPN11,RPL5
GO:0034219	carbohydrate transmembrane transport	0.013798570135727035	0.013798570135727035	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0055013	cardiac muscle cell development	0.013970959538617989	0.013970959538617989	+1	TBX3,PDGFRA,SMAD4
GO:0035108	limb morphogenesis	0.013970959538617989	0.013970959538617989	+1	CTNNB1,TBX3,FGFR2
GO:0060079	excitatory postsynaptic potential	0.013970959538617989	0.013970959538617989	+1	PTEN,AKT1,LRRK2
GO:1902808	positive regulation of cell cycle G1/S phase transition	0.013970959538617989	0.013970959538617989	+1	EGFR,AKT1,EZH2
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	0.013970959538617989	0.013970959538617989	+1	FBXW7,NFE2L2,AKT1
GO:1904262	negative regulation of TORC1 signaling	0.013970959538617989	0.013970959538617989	+1	VHL,STK11,ATM
GO:0035107	appendage morphogenesis	0.013970959538617989	0.013970959538617989	+1	CTNNB1,TBX3,FGFR2
GO:0032943	mononuclear cell proliferation	0.014057351107830624	0.014057351107830624	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:0050866	negative regulation of cell activation	0.014276623248893965	0.014276623248893965	+1	CDKN2A,RUNX1,ATM,PDGFRA,CBFB
GO:0006310	DNA recombination	0.014386140617280043	0.014386140617280043	+1	ATM,BRCA1,POLQ,SETD2,BRCA2,RAD21,ERCC2
GO:0106106	cold-induced thermogenesis	0.014640831765851526	0.014640831765851526	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0120161	regulation of cold-induced thermogenesis	0.014640831765851526	0.014640831765851526	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0006261	DNA-templated DNA replication	0.014640831765851526	0.014640831765851526	+1	ATRX,BRCA1,POLQ,BRCA2,ATR
GO:0008643	carbohydrate transport	0.014674634321308123	0.014674634321308123	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0021988	olfactory lobe development	0.014674634321308123	0.014674634321308123	+1	ERBB4,LRRK2
GO:0051216	cartilage development	0.014674634321308123	0.014674634321308123	+1	RUNX1,SOX9,FGFR3,PTPN11
GO:0071514	genomic imprinting	0.014674634321308123	0.014674634321308123	+1	DNMT3A,CTCF
GO:0048385	regulation of retinoic acid receptor signaling pathway	0.014674634321308123	0.014674634321308123	+1	ASXL1,EZH2
GO:0003143	embryonic heart tube morphogenesis	0.014674634321308123	0.014674634321308123	+1	NOTCH1,TGFBR2,SOX17
GO:0046824	positive regulation of nucleocytoplasmic transport	0.014674634321308123	0.014674634321308123	+1	PIK3R1,CDH1,EP300
GO:0072207	metanephric epithelium development	0.014674634321308123	0.014674634321308123	+1	SOX9,WT1
GO:0061371	determination of heart left/right asymmetry	0.014674634321308123	0.014674634321308123	+1	NOTCH1,TGFBR2,SOX17
GO:0010038	response to metal ion	0.014862386687767452	0.014862386687767452	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:0048812	neuron projection morphogenesis	0.015289116776525596	0.015289116776525596	+1	PTEN,NOTCH1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A
GO:0038093	Fc receptor signaling pathway	0.015539626626341634	0.015539626626341634	+1	MAP3K1,MAP2K4,KIT
GO:0044818	mitotic G2/M transition checkpoint	0.015539626626341634	0.015539626626341634	+1	ATM,BRCA1,CDKN1A
GO:0120034	positive regulation of plasma membrane bounded cell projection assembly	0.01572061853901514	0.01572061853901514	+1	PIK3CA,APC,PIK3R1,ARHGAP35
GO:0051147	regulation of muscle cell differentiation	0.01572061853901514	0.01572061853901514	+1	NOTCH1,KIT,FGFR2,SMAD4
GO:1902850	microtubule cytoskeleton organization involved in mitosis	0.016157632508575093	0.016157632508575093	+1	STAG2,CHEK2,SETD2,SMC1A,SMC3
GO:0031398	positive regulation of protein ubiquitination	0.01629347506986683	0.01629347506986683	+1	PTEN,FBXW7,BRCA1,LRRK2
GO:0010638	positive regulation of organelle organization	0.01633038228624124	0.01633038228624124	+1	TP53,NAV3,RB1,CTNNB1,ARHGAP35,ATM,ATRX,ATR,RAD21
GO:0120036	plasma membrane bounded cell projection organization	0.01633038228624124	0.01633038228624124	+1	PIK3CA,PTEN,APC,PBRM1,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,KIT,EP300,FGFR2,USP9X,SIN3A
GO:2000177	regulation of neural precursor cell proliferation	0.016334174590918155	0.016334174590918155	+1	NF1,CTNNB1,LRRK2
GO:0002042	cell migration involved in sprouting angiogenesis	0.016334174590918155	0.016334174590918155	+1	NOTCH1,AKT1,EGR3
GO:0060840	artery development	0.016334174590918155	0.016334174590918155	+1	NF1,NOTCH1,TGFBR2
GO:0060415	muscle tissue morphogenesis	0.016334174590918155	0.016334174590918155	+1	NOTCH1,FGFR2,SMAD4
GO:0048644	muscle organ morphogenesis	0.016334174590918155	0.016334174590918155	+1	NOTCH1,FGFR2,SMAD4
GO:0032331	negative regulation of chondrocyte differentiation	0.016507708006797565	0.016507708006797565	+1	SOX9,PTPN11
GO:0006103	2-oxoglutarate metabolic process	0.016507708006797565	0.016507708006797565	+1	IDH1,IDH2
GO:0007252	I-kappaB phosphorylation	0.016507708006797565	0.016507708006797565	+1	AKT1,TLR4
GO:0035994	response to muscle stretch	0.016507708006797565	0.016507708006797565	+1	PIK3CA,CTNNB1
GO:0005975	carbohydrate metabolic process	0.016507708006797565	0.016507708006797565	+1	TP53,AKT1,BRAF,MTOR,IDH2,EP300,FOXA2,NCOR1
GO:1901201	regulation of extracellular matrix assembly	0.016507708006797565	0.016507708006797565	+1	NOTCH1,SMAD4
GO:0035162	embryonic hemopoiesis	0.016507708006797565	0.016507708006797565	+1	KIT,TGFBR2
GO:0072111	cell proliferation involved in kidney development	0.016507708006797565	0.016507708006797565	+1	GATA3,WT1
GO:0010594	regulation of endothelial cell migration	0.01682304230028857	0.01682304230028857	+1	NF1,GATA3,NOTCH1,AKT1,PIK3CG
GO:0045670	regulation of osteoclast differentiation	0.01714756573390328	0.01714756573390328	+1	FBXW7,MTOR,TLR4
GO:1901880	negative regulation of protein depolymerization	0.01714756573390328	0.01714756573390328	+1	PIK3CA,APC,NAV3
GO:0042063	gliogenesis	0.017241578878789524	0.017241578878789524	+1	PTEN,NF1,NOTCH1,SOX9,PRX
GO:0032259	methylation	0.01769675038845709	0.01769675038845709	+1	DNMT3A,AKT1,WT1,ATRX,SETD2
GO:0001952	regulation of cell-matrix adhesion	0.01786254804052456	0.01786254804052456	+1	PTEN,NF1,CDKN2A,EPHA3
GO:0046854	phosphatidylinositol phosphate biosynthetic process	0.0180553382090661	0.0180553382090661	+1	PIK3CA,PIK3R1,PIK3CG
GO:0001101	response to acid chemical	0.0180553382090661	0.0180553382090661	+1	PIK3CA,MTOR,EP300
GO:0046323	glucose import	0.0180553382090661	0.0180553382090661	+1	PIK3R1,AKT1,PTPN11
GO:0002683	negative regulation of immune system process	0.018259364543651346	0.018259364543651346	+1	CDKN2A,FBXW7,RUNX1,AKT1,SOX9,ATM,TLR4,CBFB
GO:0030030	cell projection organization	0.018259364543651346	0.018259364543651346	+1	PIK3CA,PTEN,APC,PBRM1,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,KIT,EP300,FGFR2,USP9X,SIN3A
GO:0009952	anterior/posterior pattern specification	0.0184134855394684	0.0184134855394684	+1	TBX3,WT1,FOXA2,SMAD2
GO:0120039	plasma membrane bounded cell projection morphogenesis	0.0184134855394684	0.0184134855394684	+1	PTEN,NOTCH1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A
GO:0002320	lymphoid progenitor cell differentiation	0.018432930911532006	0.018432930911532006	+1	NOTCH1,FLT3
GO:0061037	negative regulation of cartilage development	0.018432930911532006	0.018432930911532006	+1	SOX9,PTPN11
GO:0072012	glomerulus vasculature development	0.018432930911532006	0.018432930911532006	+1	WT1,PDGFRA
GO:0051444	negative regulation of ubiquitin-protein transferase activity	0.018432930911532006	0.018432930911532006	+1	CDKN2A,RPL5
GO:0048854	brain morphogenesis	0.018432930911532006	0.018432930911532006	+1	PTEN,NF1
GO:0003338	metanephros morphogenesis	0.018432930911532006	0.018432930911532006	+1	SOX9,WT1
GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	0.018432930911532006	0.018432930911532006	+1	RUNX1,CBFB
GO:0110110	positive regulation of animal organ morphogenesis	0.018432930911532006	0.018432930911532006	+1	GATA3,SOX9
GO:0001569	branching involved in blood vessel morphogenesis	0.018432930911532006	0.018432930911532006	+1	CTNNB1,TGFBR2
GO:0007409	axonogenesis	0.01844101442961434	0.01844101442961434	+1	PTEN,NOTCH1,ARHGAP35,EPHA3,FGFR2,USP9X,SIN3A
GO:0002065	columnar/cuboidal epithelial cell differentiation	0.018814443726808384	0.018814443726808384	+1	AKT1,FGFR2,SMAD2
GO:0046635	positive regulation of alpha-beta T cell activation	0.018814443726808384	0.018814443726808384	+1	RUNX1,TGFBR2,CBFB
GO:0060390	regulation of SMAD protein signal transduction	0.018814443726808384	0.018814443726808384	+1	SMAD4,TGFBR2,ACVR2A
GO:1903038	negative regulation of leukocyte cell-cell adhesion	0.018843947856122516	0.018843947856122516	+1	CDKN2A,RUNX1,AKT1,CBFB
GO:0048858	cell projection morphogenesis	0.019224321425208503	0.019224321425208503	+1	PTEN,NOTCH1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A
GO:1990845	adaptive thermogenesis	0.019275500310073444	0.019275500310073444	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0043534	blood vessel endothelial cell migration	0.01946498949834041	0.01946498949834041	+1	NF1,NOTCH1,AKT1,EGR3
GO:0010812	negative regulation of cell-substrate adhesion	0.019715040519169724	0.019715040519169724	+1	PTEN,CDKN2A,NOTCH1
GO:0001836	release of cytochrome c from mitochondria	0.019715040519169724	0.019715040519169724	+1	TP53,AKT1,HGF
GO:0099565	chemical synaptic transmission, postsynaptic	0.019715040519169724	0.019715040519169724	+1	PTEN,AKT1,LRRK2
GO:0035050	embryonic heart tube development	0.019715040519169724	0.019715040519169724	+1	NOTCH1,TGFBR2,SOX17
GO:0046637	regulation of alpha-beta T cell differentiation	0.019715040519169724	0.019715040519169724	+1	RUNX1,TGFBR2,CBFB
GO:0051179	localization	0.01989400541972333	0.01989400541972333	+1	TP53,PIK3CA,PTEN,APC,EGFR,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,TBX3,STK11,EPHA3,AKT1,BRAF,AR,PIK3CG,ATM,CDKN1B,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,KIT,SETD2,EP300,FOXA2,USP9X,BRCA2,TGFBR2,ATR,SIN3A,PTPN11,MAPK8IP1,SPOP,AXIN2,RAD21
GO:0120035	regulation of plasma membrane bounded cell projection organization	0.020159160110967283	0.020159160110967283	+1	PIK3CA,PTEN,APC,PIK3R1,ARHGAP35,EPHA3,AKT1,LRRK2,EP300
GO:0055003	cardiac myofibril assembly	0.020334875621625396	0.020334875621625396	+1	PDGFRA,SMAD4
GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	0.020334875621625396	0.020334875621625396	+1	VHL,PPP2R1A
GO:0061437	renal system vasculature development	0.020334875621625396	0.020334875621625396	+1	WT1,PDGFRA
GO:0061440	kidney vasculature development	0.020334875621625396	0.020334875621625396	+1	WT1,PDGFRA
GO:0007351	tripartite regional subdivision	0.020334875621625396	0.020334875621625396	+1	TBX3,WT1
GO:0014037	Schwann cell differentiation	0.020334875621625396	0.020334875621625396	+1	NF1,PRX
GO:1900543	negative regulation of purine nucleotide metabolic process	0.020334875621625396	0.020334875621625396	+1	TP53,NCOR1
GO:0010224	response to UV-B	0.020334875621625396	0.020334875621625396	+1	STK11,CDKN1A
GO:0008595	anterior/posterior axis specification, embryo	0.020334875621625396	0.020334875621625396	+1	TBX3,WT1
GO:0007350	blastoderm segmentation	0.020334875621625396	0.020334875621625396	+1	TBX3,WT1
GO:0038092	nodal signaling pathway	0.020334875621625396	0.020334875621625396	+1	ACVR1B,SMAD2
GO:0090201	negative regulation of release of cytochrome c from mitochondria	0.020334875621625396	0.020334875621625396	+1	AKT1,HGF
GO:0032204	regulation of telomere maintenance	0.02045812485132445	0.02045812485132445	+1	CTNNB1,ATM,ATRX,ATR
GO:0021537	telencephalon development	0.02045812485132445	0.02045812485132445	+1	PTEN,NF1,ERBB4,LRRK2
GO:0002520	immune system development	0.02045812485132445	0.02045812485132445	+1	TP53,GATA3,POLQ,TGFBR2
GO:0006368	transcription elongation by RNA polymerase II	0.02045812485132445	0.02045812485132445	+1	VHL,PBRM1,SETD2,CDK12
GO:0032210	regulation of telomere maintenance via telomerase	0.020468580896832685	0.020468580896832685	+1	CTNNB1,ATM,ATR
GO:0032886	regulation of microtubule-based process	0.02054274617845928	0.02054274617845928	+1	APC,NAV3,NPM1,STK11,EPHA3,BRCA1
GO:0016331	morphogenesis of embryonic epithelium	0.020683208790161348	0.020683208790161348	+1	GATA3,SOX9,FGFR2
GO:0043434	response to peptide hormone	0.020683208790161348	0.020683208790161348	+1	PIK3CA,APC,PIK3R1,AKT1,MTOR,PTPN11
GO:0006383	transcription by RNA polymerase III	0.020683208790161348	0.020683208790161348	+1	AR,MTOR,SF3B1
GO:0072175	epithelial tube formation	0.020683208790161348	0.020683208790161348	+1	GATA3,SOX9,FGFR2
GO:0001659	temperature homeostasis	0.020683208790161348	0.020683208790161348	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0010810	regulation of cell-substrate adhesion	0.020683208790161348	0.020683208790161348	+1	PTEN,NF1,CDKN2A,NOTCH1,EPHA3
GO:0002274	myeloid leukocyte activation	0.020683208790161348	0.020683208790161348	+1	CEBPA,PIK3CG,TLR4,KIT,TGFBR2
GO:0019953	sexual reproduction	0.020683208790161348	0.020683208790161348	+1	PTEN,DNMT3A,CTCF,SOX9,ATM,WT1,KIT,USP9X,SMC1A,SMC3,RAD21
GO:0032970	regulation of actin filament-based process	0.020683208790161348	0.020683208790161348	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,MTOR,PDGFRA,SMAD4
GO:0071425	hematopoietic stem cell proliferation	0.020919215745691683	0.020919215745691683	+1	RUNX1,MECOM
GO:0070102	interleukin-6-mediated signaling pathway	0.020919215745691683	0.020919215745691683	+1	CEBPA,SMAD4
GO:0045980	negative regulation of nucleotide metabolic process	0.020919215745691683	0.020919215745691683	+1	TP53,NCOR1
GO:0014014	negative regulation of gliogenesis	0.020919215745691683	0.020919215745691683	+1	NF1,NOTCH1
GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	0.020919215745691683	0.020919215745691683	+1	RUNX1,TGFBR2,CBFB
GO:2000811	negative regulation of anoikis	0.020919215745691683	0.020919215745691683	+1	PIK3CA,NOTCH1
GO:0048147	negative regulation of fibroblast proliferation	0.020919215745691683	0.020919215745691683	+1	TP53,NF1
GO:0043032	positive regulation of macrophage activation	0.020919215745691683	0.020919215745691683	+1	CEBPA,TLR4
GO:0050776	regulation of immune response	0.02108633198939745	0.02108633198939745	+1	PIK3CA,PIK3R1,GATA3,MAP3K1,NFE2L2,MAP2K4,AKT1,TLR4,KIT,EP300,SIN3A,PTPN11
GO:0051250	negative regulation of lymphocyte activation	0.021492203229396344	0.021492203229396344	+1	CDKN2A,RUNX1,ATM,CBFB
GO:0006470	protein dephosphorylation	0.021781835441798642	0.021781835441798642	+1	PTEN,STK11,MTOR,PPP2R1A,PTPN11
GO:0010965	regulation of mitotic sister chromatid separation	0.021922778857118488	0.021922778857118488	+1	APC,RB1,ATM
GO:0031344	regulation of cell projection organization	0.022019486830046366	0.022019486830046366	+1	PIK3CA,PTEN,APC,PIK3R1,ARHGAP35,EPHA3,AKT1,LRRK2,EP300
GO:0120032	regulation of plasma membrane bounded cell projection assembly	0.022265323796475733	0.022265323796475733	+1	PIK3CA,APC,PIK3R1,ARHGAP35,AKT1
GO:0019216	regulation of lipid metabolic process	0.02255826635993105	0.02255826635993105	+1	FBXW7,AKT1,SOX9,MTOR,BRCA1,NCOR1
GO:1904951	positive regulation of establishment of protein localization	0.02255826635993105	0.02255826635993105	+1	PIK3R1,FBXW7,CDH1,BAP1,TLR4,EP300
GO:0000724	double-strand break repair via homologous recombination	0.0227387396142227	0.0227387396142227	+1	BRCA1,POLQ,SETD2,BRCA2,RAD21
GO:0060491	regulation of cell projection assembly	0.0227387396142227	0.0227387396142227	+1	PIK3CA,APC,PIK3R1,ARHGAP35,AKT1
GO:0072655	establishment of protein localization to mitochondrion	0.02274614531056088	0.02274614531056088	+1	FBXW7,BAP1,AKT1,LRRK2
GO:0030183	B cell differentiation	0.02274614531056088	0.02274614531056088	+1	PIK3R1,FLT3,ATM,KIT
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	0.02283301695844537	0.02283301695844537	+1	ATM,BRCA1,CDKN1A
GO:0030032	lamellipodium assembly	0.02283301695844537	0.02283301695844537	+1	PIK3CA,PIK3R1,KIT
GO:1903578	regulation of ATP metabolic process	0.02283301695844537	0.02283301695844537	+1	MTOR,EP300,NCOR1
GO:0003184	pulmonary valve morphogenesis	0.022851431061188223	0.022851431061188223	+1	NOTCH1,SMAD2
GO:0035313	wound healing, spreading of epidermal cells	0.022851431061188223	0.022851431061188223	+1	PTEN,MTOR
GO:0060350	endochondral bone morphogenesis	0.022851431061188223	0.022851431061188223	+1	SOX9,FGFR3
GO:0006098	pentose-phosphate shunt	0.022851431061188223	0.022851431061188223	+1	TP53,MTOR
GO:0048713	regulation of oligodendrocyte differentiation	0.022851431061188223	0.022851431061188223	+1	NF1,NOTCH1
GO:0070723	response to cholesterol	0.022851431061188223	0.022851431061188223	+1	TGFBR2,SMAD2
GO:0043029	T cell homeostasis	0.022851431061188223	0.022851431061188223	+1	AKT1,PPP2R1A
GO:0021955	central nervous system neuron axonogenesis	0.022851431061188223	0.022851431061188223	+1	PTEN,ARHGAP35
GO:0001655	urogenital system development	0.022851431061188223	0.022851431061188223	+1	SOX9,FGFR2
GO:1902903	regulation of supramolecular fiber organization	0.02294276763367684	0.02294276763367684	+1	PIK3CA,APC,NAV3,PIK3R1,RB1,ARHGAP35,SMAD4
GO:0010565	regulation of cellular ketone metabolic process	0.023216993860293307	0.023216993860293307	+1	AKT1,SOX9,BRCA1,NCOR1
GO:0030856	regulation of epithelial cell differentiation	0.023216993860293307	0.023216993860293307	+1	GATA3,CTNNB1,SOX9,VEZF1
GO:0046700	heterocycle catabolic process	0.023380024390149173	0.023380024390149173	+1	CDKN2A,NPM1,AKT1,ATM,MTOR,TET2,EP300,NCOR1,AXIN2
GO:0044270	cellular nitrogen compound catabolic process	0.023380024390149173	0.023380024390149173	+1	CDKN2A,NPM1,AKT1,ATM,MTOR,TET2,EP300,NCOR1,AXIN2
GO:0044248	cellular catabolic process	0.023399253215840955	0.023399253215840955	+1	TP53,PIK3CA,VHL,CDKN2A,FBXW7,KEAP1,NPM1,STK11,AKT1,ATM,HGF,MTOR,TET2,LRRK2,SETD2,EP300,NCOR1,AXIN2
GO:0097306	cellular response to alcohol	0.02363841867988412	0.02363841867988412	+1	CTNNB1,CDH1,BRCA1
GO:2000243	positive regulation of reproductive process	0.02363841867988412	0.02363841867988412	+1	SOX9,WT1,ACVR1B
GO:0051306	mitotic sister chromatid separation	0.02363841867988412	0.02363841867988412	+1	APC,RB1,ATM
GO:0000209	protein polyubiquitination	0.024363413365928475	0.024363413365928475	+1	CDKN2A,CTNNB1,BRCA1,TAF1,CBFB,SPOP
GO:0000725	recombinational repair	0.02453273468085316	0.02453273468085316	+1	BRCA1,POLQ,SETD2,BRCA2,RAD21
GO:0150116	regulation of cell-substrate junction organization	0.024685265548466735	0.024685265548466735	+1	PTEN,PIK3R1,EPHA3
GO:0032092	positive regulation of protein binding	0.024685265548466735	0.024685265548466735	+1	LRRK2,USP9X,TAF1
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	0.024685265548466735	0.024685265548466735	+1	TP53,STK11,EP300
GO:0032069	regulation of nuclease activity	0.02488698995435713	0.02488698995435713	+1	NPM1,AKT1
GO:0034405	response to fluid shear stress	0.02488698995435713	0.02488698995435713	+1	NFE2L2,AKT1
GO:0030277	maintenance of gastrointestinal epithelium	0.02488698995435713	0.02488698995435713	+1	SOX9,TLR4
GO:0048566	embryonic digestive tract development	0.02488698995435713	0.02488698995435713	+1	PDGFRA,FGFR2
GO:1904893	negative regulation of receptor signaling pathway via STAT	0.02488698995435713	0.02488698995435713	+1	VHL,PPP2R1A
GO:0033233	regulation of protein sumoylation	0.02488698995435713	0.02488698995435713	+1	CDKN2A,CTNNB1
GO:2000434	regulation of protein neddylation	0.02488698995435713	0.02488698995435713	+1	CDKN2A,RPL5
GO:2001236	regulation of extrinsic apoptotic signaling pathway	0.025120854174011633	0.025120854174011633	+1	AKT1,AR,TLR4,BRCA1
GO:0001819	positive regulation of cytokine production	0.02522800351653085	0.02522800351653085	+1	GATA3,RUNX1,PIK3CG,TLR4,BRCA1,KIT,SETD2,PTPN11
GO:1902750	negative regulation of cell cycle G2/M phase transition	0.02562578340953514	0.02562578340953514	+1	ATM,BRCA1,CDKN1A
GO:0006360	transcription by RNA polymerase I	0.02562578340953514	0.02562578340953514	+1	MTOR,SF3B1,TAF1
GO:0043242	negative regulation of protein-containing complex disassembly	0.02562578340953514	0.02562578340953514	+1	PIK3CA,APC,NAV3
GO:0033157	regulation of intracellular protein transport	0.025724500846118194	0.025724500846118194	+1	PIK3R1,CDKN2A,CDH1,EP300
GO:0030168	platelet activation	0.025724500846118194	0.025724500846118194	+1	PIK3CA,PIK3CG,TLR4,PDGFRA
GO:0007369	gastrulation	0.025724500846118194	0.025724500846118194	+1	SETD2,FOXA2,SOX17,SMAD2
GO:0006606	protein import into nucleus	0.025724500846118194	0.025724500846118194	+1	PIK3R1,CDH1,AKT1,EP300
GO:0032388	positive regulation of intracellular transport	0.025724500846118194	0.025724500846118194	+1	PIK3R1,CDH1,STK11,EP300
GO:0050878	regulation of body fluid levels	0.02584804480115398	0.02584804480115398	+1	PIK3CA,PIK3CG,ERBB4,TLR4,PDGFRA,FOXA2
GO:0007596	blood coagulation	0.026448813236426044	0.026448813236426044	+1	PIK3CA,PIK3CG,TLR4,PDGFRA,FOXA2
GO:0030177	positive regulation of Wnt signaling pathway	0.026448813236426044	0.026448813236426044	+1	EGFR,LRRK2,FGFR2,TBL1XR1
GO:0019439	aromatic compound catabolic process	0.02660026946631859	0.02660026946631859	+1	CDKN2A,NPM1,AKT1,ATM,MTOR,TET2,EP300,NCOR1,AXIN2
GO:0021782	glial cell development	0.02660026946631859	0.02660026946631859	+1	PTEN,NF1,PRX
GO:0035825	homologous recombination	0.02660026946631859	0.02660026946631859	+1	ATM,BRCA1,RAD21
GO:2000679	positive regulation of transcription regulatory region DNA binding	0.026967528106466816	0.026967528106466816	+1	GATA3,RB1
GO:0001709	cell fate determination	0.026967528106466816	0.026967528106466816	+1	GATA3,SOX17
GO:0051443	positive regulation of ubiquitin-protein transferase activity	0.026967528106466816	0.026967528106466816	+1	PTEN,FBXW7
GO:0046639	negative regulation of alpha-beta T cell differentiation	0.026967528106466816	0.026967528106466816	+1	RUNX1,CBFB
GO:0032925	regulation of activin receptor signaling pathway	0.026967528106466816	0.026967528106466816	+1	ACVR1B,ACVR2A
GO:0070585	protein localization to mitochondrion	0.027064392808022215	0.027064392808022215	+1	FBXW7,BAP1,AKT1,LRRK2
GO:0031346	positive regulation of cell projection organization	0.027064392808022215	0.027064392808022215	+1	PIK3CA,APC,PIK3R1,ARHGAP35,EPHA3,EP300
GO:0072659	protein localization to plasma membrane	0.027064392808022215	0.027064392808022215	+1	EGFR,PIK3R1,CDH1,EPHA3,AKT1,AR
GO:0032200	telomere organization	0.02740298240138657	0.02740298240138657	+1	CTNNB1,ATM,ATRX,ATR,EZH2
GO:0007517	muscle organ development	0.02740298240138657	0.02740298240138657	+1	NOTCH1,WT1,FGFR2,SMAD4,EGR3
GO:1904356	regulation of telomere maintenance via telomere lengthening	0.02753189444144127	0.02753189444144127	+1	CTNNB1,ATM,ATR
GO:0061045	negative regulation of wound healing	0.02753189444144127	0.02753189444144127	+1	PTEN,EPPK1,PDGFRA
GO:0060078	regulation of postsynaptic membrane potential	0.02753189444144127	0.02753189444144127	+1	PTEN,AKT1,LRRK2
GO:0048839	inner ear development	0.02753189444144127	0.02753189444144127	+1	SOX9,FGFR2,PTPN11
GO:0046328	regulation of JNK cascade	0.02767679797571458	0.02767679797571458	+1	EGFR,MAPK8IP1,MECOM,NCOR1
GO:0051236	establishment of RNA localization	0.02767679797571458	0.02767679797571458	+1	ATM,SETD2,TGFBR2,ATR
GO:0055001	muscle cell development	0.028471306408866196	0.028471306408866196	+1	NOTCH1,TBX3,PDGFRA,SMAD4
GO:0050817	coagulation	0.02848115354774902	0.02848115354774902	+1	PIK3CA,PIK3CG,TLR4,PDGFRA,FOXA2
GO:1901879	regulation of protein depolymerization	0.028636788959809097	0.028636788959809097	+1	PIK3CA,APC,NAV3
GO:0010633	negative regulation of epithelial cell migration	0.028636788959809097	0.028636788959809097	+1	PTEN,NOTCH1,EPPK1
GO:0001936	regulation of endothelial cell proliferation	0.029115430319456813	0.029115430319456813	+1	NF1,NRAS,AKT1,EGR3
GO:0006661	phosphatidylinositol biosynthetic process	0.029115430319456813	0.029115430319456813	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
GO:0006740	NADPH regeneration	0.029115430319456813	0.029115430319456813	+1	TP53,MTOR
GO:0007026	negative regulation of microtubule depolymerization	0.029115430319456813	0.029115430319456813	+1	APC,NAV3
GO:2000001	regulation of DNA damage checkpoint	0.029115430319456813	0.029115430319456813	+1	BRCA1,BRCA2
GO:0051170	import into nucleus	0.029115430319456813	0.029115430319456813	+1	PIK3R1,CDH1,AKT1,EP300
GO:0007599	hemostasis	0.029563953964735285	0.029563953964735285	+1	PIK3CA,PIK3CG,TLR4,PDGFRA,FOXA2
GO:0060996	dendritic spine development	0.0296799297085595	0.0296799297085595	+1	PTEN,PBRM1,LRRK2
GO:0060541	respiratory system development	0.0296799297085595	0.0296799297085595	+1	CEBPA,WT1,FGFR2
GO:0010906	regulation of glucose metabolic process	0.0296799297085595	0.0296799297085595	+1	AKT1,EP300,FOXA2
GO:0006354	DNA-templated transcription elongation	0.029850107232086753	0.029850107232086753	+1	VHL,PBRM1,SETD2,CDK12
GO:0061564	axon development	0.03040374972270122	0.03040374972270122	+1	PTEN,NOTCH1,ARHGAP35,EPHA3,FGFR2,USP9X,SIN3A
GO:0016052	carbohydrate catabolic process	0.030637777432819518	0.030637777432819518	+1	TP53,MTOR,EP300,NCOR1
GO:0008361	regulation of cell size	0.030637777432819518	0.030637777432819518	+1	PTEN,ARHGAP35,MTOR,SIN3A
GO:0031667	response to nutrient levels	0.030644117718370147	0.030644117718370147	+1	TP53,MTOR,LRRK2,EP300,FOXA2,CDKN1A
GO:2000209	regulation of anoikis	0.03129272771816479	0.03129272771816479	+1	PIK3CA,NOTCH1
GO:2000108	positive regulation of leukocyte apoptotic process	0.03129272771816479	0.03129272771816479	+1	TP53,CDKN2A
GO:0032727	positive regulation of interferon-alpha production	0.03129272771816479	0.03129272771816479	+1	TLR4,SETD2
GO:0003177	pulmonary valve development	0.03129272771816479	0.03129272771816479	+1	NOTCH1,SMAD2
GO:0046599	regulation of centriole replication	0.03129272771816479	0.03129272771816479	+1	NPM1,BRCA1
GO:0035315	hair cell differentiation	0.03129272771816479	0.03129272771816479	+1	CTNNB1,ERCC2
GO:0045671	negative regulation of osteoclast differentiation	0.03129272771816479	0.03129272771816479	+1	FBXW7,TLR4
GO:0070168	negative regulation of biomineral tissue development	0.03129272771816479	0.03129272771816479	+1	NOTCH1,SOX9
GO:0035886	vascular associated smooth muscle cell differentiation	0.03129272771816479	0.03129272771816479	+1	NOTCH1,KIT
GO:0038095	Fc-epsilon receptor signaling pathway	0.03129272771816479	0.03129272771816479	+1	MAP3K1,MAP2K4
GO:0032481	positive regulation of type I interferon production	0.03190310484286914	0.03190310484286914	+1	TLR4,SETD2,PTPN11
GO:0007052	mitotic spindle organization	0.0320932627122698	0.0320932627122698	+1	STAG2,CHEK2,SMC1A,SMC3
GO:0007005	mitochondrion organization	0.0329133224238811	0.0329133224238811	+1	TP53,CDKN2A,FBXW7,AKT1,HGF,ERBB4,LRRK2,EP300
GO:0051640	organelle localization	0.03302944366616764	0.03302944366616764	+1	PTEN,APC,RB1,NPM1,STK11,PIK3CG,MTOR,LRRK2,KIT
GO:0048736	appendage development	0.03306518567691505	0.03306518567691505	+1	CTNNB1,TBX3,FGFR2
GO:0032007	negative regulation of TOR signaling	0.03306518567691505	0.03306518567691505	+1	VHL,STK11,ATM
GO:0030901	midbrain development	0.03306518567691505	0.03306518567691505	+1	CTNNB1,FGFR2,TAF1
GO:0060173	limb development	0.03306518567691505	0.03306518567691505	+1	CTNNB1,TBX3,FGFR2
GO:0030851	granulocyte differentiation	0.03353574217938346	0.03353574217938346	+1	RUNX1,CEBPA
GO:0002067	glandular epithelial cell differentiation	0.03353574217938346	0.03353574217938346	+1	AKT1,FGFR2
GO:0071404	cellular response to low-density lipoprotein particle stimulus	0.03353574217938346	0.03353574217938346	+1	AKT1,TLR4
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.03353574217938346	0.03353574217938346	+1	NFE2L2,AKT1
GO:0050999	regulation of nitric-oxide synthase activity	0.03353574217938346	0.03353574217938346	+1	EGFR,AKT1
GO:0050869	negative regulation of B cell activation	0.03353574217938346	0.03353574217938346	+1	CDKN2A,ATM
GO:1902894	negative regulation of miRNA transcription	0.03353574217938346	0.03353574217938346	+1	SOX9,NCOR1
GO:0030513	positive regulation of BMP signaling pathway	0.03353574217938346	0.03353574217938346	+1	NOTCH1,SMAD2
GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	0.03353574217938346	0.03353574217938346	+1	RUNX1,CBFB
GO:0010592	positive regulation of lamellipodium assembly	0.03353574217938346	0.03353574217938346	+1	PIK3CA,PIK3R1
GO:0036314	response to sterol	0.03353574217938346	0.03353574217938346	+1	TGFBR2,SMAD2
GO:1901361	organic cyclic compound catabolic process	0.03421435234231399	0.03421435234231399	+1	CDKN2A,NPM1,AKT1,ATM,MTOR,TET2,EP300,NCOR1,AXIN2
GO:0002695	negative regulation of leukocyte activation	0.035269100175384684	0.035269100175384684	+1	CDKN2A,RUNX1,ATM,CBFB
GO:0010669	epithelial structure maintenance	0.035269100175384684	0.035269100175384684	+1	SOX9,TLR4
GO:0007098	centrosome cycle	0.035269100175384684	0.035269100175384684	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:0006278	RNA-templated DNA biosynthetic process	0.035269100175384684	0.035269100175384684	+1	CTNNB1,ATM,ATR
GO:0007004	telomere maintenance via telomerase	0.035269100175384684	0.035269100175384684	+1	CTNNB1,ATM,ATR
GO:0018205	peptidyl-lysine modification	0.035269100175384684	0.035269100175384684	+1	CDKN2A,CTNNB1,SETD2,EP300
GO:1903533	regulation of protein targeting	0.035269100175384684	0.035269100175384684	+1	FBXW7,BAP1,LRRK2
GO:0055094	response to lipoprotein particle	0.035269100175384684	0.035269100175384684	+1	AKT1,TLR4
GO:1900181	negative regulation of protein localization to nucleus	0.035269100175384684	0.035269100175384684	+1	MTOR,SIN3A
GO:0042113	B cell activation	0.035269100175384684	0.035269100175384684	+1	PIK3R1,CDKN2A,FLT3,ATM,KIT
GO:0045739	positive regulation of DNA repair	0.035269100175384684	0.035269100175384684	+1	ARID1A,PBRM1,EGFR,BRCA1
GO:2000352	negative regulation of endothelial cell apoptotic process	0.035269100175384684	0.035269100175384684	+1	GATA3,NFE2L2
GO:0048588	developmental cell growth	0.035269100175384684	0.035269100175384684	+1	CTNNB1,SOX9,USP9X,SIN3A
GO:0043367	CD4-positive, alpha-beta T cell differentiation	0.035269100175384684	0.035269100175384684	+1	GATA3,RUNX1,CBFB
GO:1905818	regulation of chromosome separation	0.035269100175384684	0.035269100175384684	+1	APC,RB1,ATM
GO:1905332	positive regulation of morphogenesis of an epithelium	0.035269100175384684	0.035269100175384684	+1	GATA3,SOX9
GO:1902751	positive regulation of cell cycle G2/M phase transition	0.035269100175384684	0.035269100175384684	+1	NPM1,CCND1
GO:0033146	regulation of intracellular estrogen receptor signaling pathway	0.035269100175384684	0.035269100175384684	+1	BRCA1,FOXA1
GO:0060326	cell chemotaxis	0.03581603673784977	0.03581603673784977	+1	NOTCH1,PIK3CG,HGF,KIT,PDGFRA,EGR3
GO:0051298	centrosome duplication	0.03605359278506379	0.03605359278506379	+1	NPM1,BRCA1,BRCA2
GO:0031114	regulation of microtubule depolymerization	0.03663811370450345	0.03663811370450345	+1	APC,NAV3
GO:0045648	positive regulation of erythrocyte differentiation	0.03663811370450345	0.03663811370450345	+1	ACVR1B,ACVR2A
GO:0048384	retinoic acid receptor signaling pathway	0.03663811370450345	0.03663811370450345	+1	ASXL1,EZH2
GO:0010837	regulation of keratinocyte proliferation	0.03663811370450345	0.03663811370450345	+1	EPPK1,FGFR2
GO:0071402	cellular response to lipoprotein particle stimulus	0.03663811370450345	0.03663811370450345	+1	AKT1,TLR4
GO:2000629	negative regulation of miRNA metabolic process	0.03663811370450345	0.03663811370450345	+1	SOX9,NCOR1
GO:0006096	glycolytic process	0.037211120319470964	0.037211120319470964	+1	MTOR,EP300,NCOR1
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	0.037211120319470964	0.037211120319470964	+1	AKT1,AR,BRCA1
GO:0046032	ADP catabolic process	0.037211120319470964	0.037211120319470964	+1	MTOR,EP300,NCOR1
GO:0031589	cell-substrate adhesion	0.037943272796599634	0.037943272796599634	+1	PTEN,NF1,PIK3R1,CDKN2A,NOTCH1,EPHA3
GO:0034655	nucleobase-containing compound catabolic process	0.03809782766084517	0.03809782766084517	+1	CDKN2A,NPM1,AKT1,ATM,MTOR,EP300,NCOR1,AXIN2
GO:0032091	negative regulation of protein binding	0.03848221153238966	0.03848221153238966	+1	AKT1,LRRK2,CDKN1A
GO:0097581	lamellipodium organization	0.03848221153238966	0.03848221153238966	+1	PIK3CA,PIK3R1,KIT
GO:0071887	leukocyte apoptotic process	0.03848221153238966	0.03848221153238966	+1	TP53,CDKN2A,AKT1
GO:0051321	meiotic cell cycle	0.03875330161113491	0.03875330161113491	+1	PTEN,ATM,SMC1A,SMC3,RAD21
GO:0046320	regulation of fatty acid oxidation	0.03903382643444034	0.03903382643444034	+1	AKT1,SOX9
GO:0031018	endocrine pancreas development	0.03903382643444034	0.03903382643444034	+1	AKT1,FOXA2
GO:0045740	positive regulation of DNA replication	0.03903382643444034	0.03903382643444034	+1	EGFR,ATRX
GO:2000819	regulation of nucleotide-excision repair	0.03903382643444034	0.03903382643444034	+1	ARID1A,PBRM1
GO:0030279	negative regulation of ossification	0.03903382643444034	0.03903382643444034	+1	NOTCH1,SOX9
GO:0001935	endothelial cell proliferation	0.03918999074911272	0.03918999074911272	+1	NF1,NRAS,AKT1,EGR3
GO:0046031	ADP metabolic process	0.03959794847850014	0.03959794847850014	+1	MTOR,EP300,NCOR1
GO:0009181	purine ribonucleoside diphosphate catabolic process	0.03959794847850014	0.03959794847850014	+1	MTOR,EP300,NCOR1
GO:0030316	osteoclast differentiation	0.03959794847850014	0.03959794847850014	+1	FBXW7,MTOR,TLR4
GO:0009137	purine nucleoside diphosphate catabolic process	0.03959794847850014	0.03959794847850014	+1	MTOR,EP300,NCOR1
GO:0090316	positive regulation of intracellular protein transport	0.03959794847850014	0.03959794847850014	+1	PIK3R1,CDH1,EP300
GO:0045184	establishment of protein localization	0.03998165196376584	0.03998165196376584	+1	EGFR,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,NPM1,AKT1,BRAF,TLR4,LRRK2,EP300,FOXA2,USP9X,BRCA2
GO:0006367	transcription initiation at RNA polymerase II promoter	0.03998920171429099	0.03998920171429099	+1	TP53,ARID1A,EP300,TAF1
GO:0001938	positive regulation of endothelial cell proliferation	0.04095705599617417	0.04095705599617417	+1	NRAS,AKT1,EGR3
GO:1990778	protein localization to cell periphery	0.04118929673801299	0.04118929673801299	+1	EGFR,PIK3R1,CDH1,EPHA3,AKT1,AR
GO:0035767	endothelial cell chemotaxis	0.041418939761059696	0.041418939761059696	+1	NOTCH1,EGR3
GO:2000273	positive regulation of signaling receptor activity	0.041418939761059696	0.041418939761059696	+1	FBXW7,TAF1
GO:0032647	regulation of interferon-alpha production	0.041418939761059696	0.041418939761059696	+1	TLR4,SETD2
GO:0032330	regulation of chondrocyte differentiation	0.041418939761059696	0.041418939761059696	+1	SOX9,PTPN11
GO:0051156	glucose 6-phosphate metabolic process	0.041418939761059696	0.041418939761059696	+1	TP53,MTOR
GO:0032607	interferon-alpha production	0.041418939761059696	0.041418939761059696	+1	TLR4,SETD2
GO:0031347	regulation of defense response	0.04207626548472576	0.04207626548472576	+1	PIK3R1,GATA3,RB1,NFE2L2,CEBPA,AKT1,TLR4,EP300,SIN3A,PTPN11
GO:0051304	chromosome separation	0.04210091983846572	0.04210091983846572	+1	APC,RB1,ATM
GO:0042552	myelination	0.04210091983846572	0.04210091983846572	+1	PTEN,NF1,PRX
GO:0019364	pyridine nucleotide catabolic process	0.04210091983846572	0.04210091983846572	+1	MTOR,EP300,NCOR1
GO:0009179	purine ribonucleoside diphosphate metabolic process	0.04210091983846572	0.04210091983846572	+1	MTOR,EP300,NCOR1
GO:0046890	regulation of lipid biosynthetic process	0.04259404818735279	0.04259404818735279	+1	FBXW7,AKT1,MTOR,BRCA1
GO:0009267	cellular response to starvation	0.04259404818735279	0.04259404818735279	+1	TP53,MTOR,LRRK2,CDKN1A
GO:0001817	regulation of cytokine production	0.0427157417584655	0.0427157417584655	+1	NAV3,GATA3,RUNX1,PIK3CG,TLR4,BRCA1,KIT,SETD2,SMAD4,PTPN11
GO:0009191	ribonucleoside diphosphate catabolic process	0.04339117857024393	0.04339117857024393	+1	MTOR,EP300,NCOR1
GO:0006446	regulation of translational initiation	0.04339117857024393	0.04339117857024393	+1	NPM1,MTOR,EIF4A2
GO:1903035	negative regulation of response to wounding	0.04339117857024393	0.04339117857024393	+1	PTEN,EPPK1,PDGFRA
GO:0009135	purine nucleoside diphosphate metabolic process	0.04339117857024393	0.04339117857024393	+1	MTOR,EP300,NCOR1
GO:0046488	phosphatidylinositol metabolic process	0.043454485331894575	0.043454485331894575	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
GO:0060416	response to growth hormone	0.043593781541301765	0.043593781541301765	+1	PIK3R1,AKT1
GO:0031670	cellular response to nutrient	0.043593781541301765	0.043593781541301765	+1	MTOR,FOXA2
GO:0045116	protein neddylation	0.043593781541301765	0.043593781541301765	+1	CDKN2A,RPL5
GO:0006298	mismatch repair	0.043593781541301765	0.043593781541301765	+1	SETD2,AXIN2
GO:0080111	DNA demethylation	0.043593781541301765	0.043593781541301765	+1	TET2,USP9X
GO:0097028	dendritic cell differentiation	0.043593781541301765	0.043593781541301765	+1	FLT3,TGFBR2
GO:0001658	branching involved in ureteric bud morphogenesis	0.043593781541301765	0.043593781541301765	+1	SOX9,WT1
GO:0045088	regulation of innate immune response	0.043593781541301765	0.043593781541301765	+1	PIK3R1,NFE2L2,AKT1,TLR4,EP300,SIN3A,PTPN11
GO:0071276	cellular response to cadmium ion	0.043593781541301765	0.043593781541301765	+1	EGFR,AKT1
GO:0071354	cellular response to interleukin-6	0.043593781541301765	0.043593781541301765	+1	CEBPA,SMAD4
GO:0046640	regulation of alpha-beta T cell proliferation	0.043593781541301765	0.043593781541301765	+1	TGFBR2,MAPK8IP1
GO:0045429	positive regulation of nitric oxide biosynthetic process	0.043593781541301765	0.043593781541301765	+1	AKT1,TLR4
GO:0051049	regulation of transport	0.04386125940180976	0.04386125940180976	+1	PTEN,PIK3R1,CDKN2A,NOTCH1,CTNNB1,CDH1,STK11,EPHA3,AKT1,BRAF,TLR4,LRRK2,SETD2,EP300,FOXA2,PTPN11
GO:0042098	T cell proliferation	0.044104313967293966	0.044104313967293966	+1	CDKN2A,PIK3CG,TGFBR2,MAPK8IP1
GO:0001816	cytokine production	0.044273641068552895	0.044273641068552895	+1	NAV3,GATA3,RUNX1,PIK3CG,TLR4,BRCA1,KIT,SETD2,SMAD4,PTPN11
GO:0007272	ensheathment of neurons	0.0443677854506408	0.0443677854506408	+1	PTEN,NF1,PRX
GO:0008366	axon ensheathment	0.0443677854506408	0.0443677854506408	+1	PTEN,NF1,PRX
GO:0045639	positive regulation of myeloid cell differentiation	0.0443677854506408	0.0443677854506408	+1	RUNX1,ACVR1B,ACVR2A
GO:0042593	glucose homeostasis	0.04500628665636411	0.04500628665636411	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:0002220	innate immune response activating cell surface receptor signaling pathway	0.045768339913276904	0.045768339913276904	+1	PIK3R1,TLR4,EP300
GO:0001704	formation of primary germ layer	0.045768339913276904	0.045768339913276904	+1	SETD2,SOX17,SMAD2
GO:0072526	pyridine-containing compound catabolic process	0.045768339913276904	0.045768339913276904	+1	MTOR,EP300,NCOR1
GO:1903749	positive regulation of establishment of protein localization to mitochondrion	0.04597714663271945	0.04597714663271945	+1	FBXW7,BAP1
GO:0048009	insulin-like growth factor receptor signaling pathway	0.04597714663271945	0.04597714663271945	+1	PIK3R1,AKT1
GO:1903955	positive regulation of protein targeting to mitochondrion	0.04597714663271945	0.04597714663271945	+1	FBXW7,BAP1
GO:0002260	lymphocyte homeostasis	0.04597714663271945	0.04597714663271945	+1	AKT1,PPP2R1A
GO:0046633	alpha-beta T cell proliferation	0.04597714663271945	0.04597714663271945	+1	TGFBR2,MAPK8IP1
GO:0060765	regulation of androgen receptor signaling pathway	0.04597714663271945	0.04597714663271945	+1	EP300,NCOR1
GO:0061001	regulation of dendritic spine morphogenesis	0.04597714663271945	0.04597714663271945	+1	PTEN,LRRK2
GO:1904407	positive regulation of nitric oxide metabolic process	0.04597714663271945	0.04597714663271945	+1	AKT1,TLR4
GO:0010975	regulation of neuron projection development	0.04648566996370064	0.04648566996370064	+1	PTEN,ARHGAP35,EPHA3,AKT1,LRRK2,EP300
GO:0048609	multicellular organismal reproductive process	0.04669507226665117	0.04669507226665117	+1	PTEN,DNMT3A,CTCF,SOX9,WT1,KIT,PDGFRA,USP9X
GO:0033500	carbohydrate homeostasis	0.04672418295257643	0.04672418295257643	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:0030218	erythrocyte differentiation	0.046873673433480964	0.046873673433480964	+1	KIT,ACVR1B,ACVR2A
GO:0051101	regulation of DNA binding	0.046873673433480964	0.046873673433480964	+1	GATA3,RB1,NSD1
GO:0034340	response to type I interferon	0.046873673433480964	0.046873673433480964	+1	SETD2,SIN3A,PTPN11
GO:0050768	negative regulation of neurogenesis	0.046873673433480964	0.046873673433480964	+1	PTEN,NF1,NOTCH1
GO:0016241	regulation of macroautophagy	0.04699162942980587	0.04699162942980587	+1	PIK3CA,AKT1,MTOR,LRRK2
GO:0009794	regulation of mitotic cell cycle, embryonic	0.04699162942980587	0.04699162942980587	+1	CTNNB1
GO:0060693	regulation of branching involved in salivary gland morphogenesis	0.04699162942980587	0.04699162942980587	+1	HGF
GO:0097252	oligodendrocyte apoptotic process	0.04699162942980587	0.04699162942980587	+1	TP53
GO:0033132	negative regulation of glucokinase activity	0.04699162942980587	0.04699162942980587	+1	FOXA2
GO:0033138	positive regulation of peptidyl-serine phosphorylation	0.04699162942980587	0.04699162942980587	+1	EGFR,AKT1,BRAF
GO:0060601	lateral sprouting from an epithelium	0.04699162942980587	0.04699162942980587	+1	FGFR2
GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose	0.04699162942980587	0.04699162942980587	+1	FOXA2
GO:0002513	tolerance induction to self antigen	0.04699162942980587	0.04699162942980587	+1	TGFBR2
GO:0031023	microtubule organizing center organization	0.04699162942980587	0.04699162942980587	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	0.04699162942980587	0.04699162942980587	+1	FOXA2
GO:0002514	B cell tolerance induction	0.04699162942980587	0.04699162942980587	+1	TGFBR2
GO:0072262	metanephric glomerular mesangial cell proliferation involved in metanephros development	0.04699162942980587	0.04699162942980587	+1	WT1
GO:0034092	negative regulation of maintenance of sister chromatid cohesion	0.04699162942980587	0.04699162942980587	+1	ATRX
GO:0034183	negative regulation of maintenance of mitotic sister chromatid cohesion	0.04699162942980587	0.04699162942980587	+1	ATRX
GO:0072179	nephric duct formation	0.04699162942980587	0.04699162942980587	+1	GATA3
GO:0031134	sister chromatid biorientation	0.04699162942980587	0.04699162942980587	+1	RB1
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	0.04699162942980587	0.04699162942980587	+1	LRRK2
GO:0009415	response to water	0.04699162942980587	0.04699162942980587	+1	PIK3CA
GO:0014041	regulation of neuron maturation	0.04699162942980587	0.04699162942980587	+1	LRRK2
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	0.04699162942980587	0.04699162942980587	+1	FGFR2
GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	0.04699162942980587	0.04699162942980587	+1	BRCA1,NCOR1
GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	0.04699162942980587	0.04699162942980587	+1	ASXL1
GO:0032808	lacrimal gland development	0.04699162942980587	0.04699162942980587	+1	FGFR2
GO:0016046	detection of fungus	0.04699162942980587	0.04699162942980587	+1	TLR4
GO:0032354	response to follicle-stimulating hormone	0.04699162942980587	0.04699162942980587	+1	NOTCH1
GO:0001953	negative regulation of cell-matrix adhesion	0.04699162942980587	0.04699162942980587	+1	PTEN,CDKN2A
GO:0061209	cell proliferation involved in mesonephros development	0.04699162942980587	0.04699162942980587	+1	GATA3
GO:0030950	establishment or maintenance of actin cytoskeleton polarity	0.04699162942980587	0.04699162942980587	+1	ARHGAP35
GO:0060916	mesenchymal cell proliferation involved in lung development	0.04699162942980587	0.04699162942980587	+1	FGFR2
GO:0090116	C-5 methylation of cytosine	0.04699162942980587	0.04699162942980587	+1	DNMT3A
GO:0032762	mast cell cytokine production	0.04699162942980587	0.04699162942980587	+1	KIT
GO:0046016	positive regulation of transcription by glucose	0.04699162942980587	0.04699162942980587	+1	FOXA2
GO:0032286	central nervous system myelin maintenance	0.04699162942980587	0.04699162942980587	+1	PTEN
GO:0032765	positive regulation of mast cell cytokine production	0.04699162942980587	0.04699162942980587	+1	KIT
GO:0072277	metanephric glomerular capillary formation	0.04699162942980587	0.04699162942980587	+1	PDGFRA
GO:0072125	negative regulation of glomerular mesangial cell proliferation	0.04699162942980587	0.04699162942980587	+1	WT1
GO:0030997	regulation of centriole-centriole cohesion	0.04699162942980587	0.04699162942980587	+1	CTNNB1
GO:0032763	regulation of mast cell cytokine production	0.04699162942980587	0.04699162942980587	+1	KIT
GO:0045726	positive regulation of integrin biosynthetic process	0.04699162942980587	0.04699162942980587	+1	AR
GO:0072276	metanephric glomerulus vasculature morphogenesis	0.04699162942980587	0.04699162942980587	+1	PDGFRA
GO:0060742	epithelial cell differentiation involved in prostate gland development	0.04699162942980587	0.04699162942980587	+1	FGFR2
GO:0070662	mast cell proliferation	0.04699162942980587	0.04699162942980587	+1	KIT
GO:0097155	fasciculation of sensory neuron axon	0.04699162942980587	0.04699162942980587	+1	EPHA3
GO:0072275	metanephric glomerulus morphogenesis	0.04699162942980587	0.04699162942980587	+1	PDGFRA
GO:0070231	T cell apoptotic process	0.04699162942980587	0.04699162942980587	+1	TP53,AKT1
GO:0072717	cellular response to actinomycin D	0.04699162942980587	0.04699162942980587	+1	TP53
GO:2000807	regulation of synaptic vesicle clustering	0.04699162942980587	0.04699162942980587	+1	PTEN
GO:0060374	mast cell differentiation	0.04699162942980587	0.04699162942980587	+1	KIT
GO:0036216	cellular response to stem cell factor stimulus	0.04699162942980587	0.04699162942980587	+1	KIT
GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway	0.04699162942980587	0.04699162942980587	+1	PDGFRA
GO:1904466	positive regulation of matrix metallopeptidase secretion	0.04699162942980587	0.04699162942980587	+1	TLR4
GO:0035564	regulation of kidney size	0.04699162942980587	0.04699162942980587	+1	LRRK2
GO:1904761	negative regulation of myofibroblast differentiation	0.04699162942980587	0.04699162942980587	+1	RB1
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	0.04699162942980587	0.04699162942980587	+1	PDGFRA
GO:0048865	stem cell fate commitment	0.04699162942980587	0.04699162942980587	+1	SOX9
GO:0048861	leukemia inhibitory factor signaling pathway	0.04699162942980587	0.04699162942980587	+1	LIFR
GO:0038109	Kit signaling pathway	0.04699162942980587	0.04699162942980587	+1	KIT
GO:0038162	erythropoietin-mediated signaling pathway	0.04699162942980587	0.04699162942980587	+1	KIT
GO:1905072	cardiac jelly development	0.04699162942980587	0.04699162942980587	+1	TBX3
GO:1905289	regulation of CAMKK-AMPK signaling cascade	0.04699162942980587	0.04699162942980587	+1	LRRK2
GO:0046532	regulation of photoreceptor cell differentiation	0.04699162942980587	0.04699162942980587	+1	SOX9
GO:1905552	positive regulation of protein localization to endoplasmic reticulum	0.04699162942980587	0.04699162942980587	+1	AKT1
GO:0036215	response to stem cell factor	0.04699162942980587	0.04699162942980587	+1	KIT
GO:1905643	positive regulation of DNA methylation	0.04699162942980587	0.04699162942980587	+1	WT1
GO:1905672	negative regulation of lysosome organization	0.04699162942980587	0.04699162942980587	+1	MTOR
GO:0010750	positive regulation of nitric oxide mediated signal transduction	0.04699162942980587	0.04699162942980587	+1	EGFR
GO:1905857	positive regulation of pentose-phosphate shunt	0.04699162942980587	0.04699162942980587	+1	MTOR
GO:2001205	negative regulation of osteoclast development	0.04699162942980587	0.04699162942980587	+1	FBXW7
GO:0043303	mast cell degranulation	0.04699162942980587	0.04699162942980587	+1	PIK3CG,KIT
GO:1990428	miRNA transport	0.04699162942980587	0.04699162942980587	+1	TGFBR2
GO:0010611	regulation of cardiac muscle hypertrophy	0.04699162942980587	0.04699162942980587	+1	NOTCH1,SMAD4
GO:2000111	positive regulation of macrophage apoptotic process	0.04699162942980587	0.04699162942980587	+1	CDKN2A
GO:0048146	positive regulation of fibroblast proliferation	0.04699162942980587	0.04699162942980587	+1	PDGFRA,CDKN1A
GO:2000974	negative regulation of pro-B cell differentiation	0.04699162942980587	0.04699162942980587	+1	NOTCH1
GO:0021551	central nervous system morphogenesis	0.04699162942980587	0.04699162942980587	+1	ERBB4
GO:2000825	positive regulation of androgen receptor activity	0.04699162942980587	0.04699162942980587	+1	TAF1
GO:2000279	negative regulation of DNA biosynthetic process	0.04699162942980587	0.04699162942980587	+1	TP53,CDKN1A
GO:0046686	response to cadmium ion	0.04699162942980587	0.04699162942980587	+1	EGFR,AKT1
GO:0046533	negative regulation of photoreceptor cell differentiation	0.04699162942980587	0.04699162942980587	+1	SOX9
GO:0051136	regulation of NK T cell differentiation	0.04699162942980587	0.04699162942980587	+1	TGFBR2
GO:1904760	regulation of myofibroblast differentiation	0.04699162942980587	0.04699162942980587	+1	RB1
GO:2000172	regulation of branching morphogenesis of a nerve	0.04699162942980587	0.04699162942980587	+1	LRRK2
GO:1902499	positive regulation of protein autoubiquitination	0.04699162942980587	0.04699162942980587	+1	LRRK2
GO:0003192	mitral valve formation	0.04699162942980587	0.04699162942980587	+1	NOTCH1
GO:0036023	embryonic skeletal limb joint morphogenesis	0.04699162942980587	0.04699162942980587	+1	CTNNB1
GO:1902822	regulation of late endosome to lysosome transport	0.04699162942980587	0.04699162942980587	+1	LRRK2
GO:0055118	negative regulation of cardiac muscle contraction	0.04699162942980587	0.04699162942980587	+1	PIK3CG
GO:0051599	response to hydrostatic pressure	0.04699162942980587	0.04699162942980587	+1	PIK3CA
GO:0060056	mammary gland involution	0.04699162942980587	0.04699162942980587	+1	ELF3
GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	0.04699162942980587	0.04699162942980587	+1	CTNNB1
GO:0045444	fat cell differentiation	0.04699162942980587	0.04699162942980587	+1	CEBPA,AKT1,EP300,ASXL1
GO:0010868	negative regulation of triglyceride biosynthetic process	0.04699162942980587	0.04699162942980587	+1	FBXW7
GO:0060214	endocardium formation	0.04699162942980587	0.04699162942980587	+1	SOX17
GO:1903335	regulation of vacuolar transport	0.04699162942980587	0.04699162942980587	+1	LRRK2
GO:0036022	limb joint morphogenesis	0.04699162942980587	0.04699162942980587	+1	CTNNB1
GO:0003273	cell migration involved in endocardial cushion formation	0.04699162942980587	0.04699162942980587	+1	NOTCH1
GO:0014034	neural crest cell fate commitment	0.04699162942980587	0.04699162942980587	+1	SOX9
GO:2000639	negative regulation of SREBP signaling pathway	0.04699162942980587	0.04699162942980587	+1	FBXW7
GO:0045448	mitotic cell cycle, embryonic	0.04699162942980587	0.04699162942980587	+1	CTNNB1
GO:1903300	negative regulation of hexokinase activity	0.04699162942980587	0.04699162942980587	+1	FOXA2
GO:0043535	regulation of blood vessel endothelial cell migration	0.04702361514637744	0.04702361514637744	+1	NF1,NOTCH1,AKT1
GO:0070167	regulation of biomineral tissue development	0.04702361514637744	0.04702361514637744	+1	NOTCH1,SOX9,ACVR2A
GO:0009134	nucleoside diphosphate catabolic process	0.04702361514637744	0.04702361514637744	+1	MTOR,EP300,NCOR1
GO:0043433	negative regulation of DNA-binding transcription factor activity	0.04791886579453979	0.04791886579453979	+1	CDKN2A,RB1,KEAP1,FOXA2
GO:0045746	negative regulation of Notch signaling pathway	0.04821632592125216	0.04821632592125216	+1	FBXW7,AKT1
GO:0034101	erythrocyte homeostasis	0.04821632592125216	0.04821632592125216	+1	KIT,ACVR1B,ACVR2A
GO:0098815	modulation of excitatory postsynaptic potential	0.04821632592125216	0.04821632592125216	+1	PTEN,LRRK2
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	0.04821632592125216	0.04821632592125216	+1	EGFR,AKT1
GO:0150115	cell-substrate junction organization	0.04821632592125216	0.04821632592125216	+1	PTEN,PIK3R1,EPHA3
GO:1902745	positive regulation of lamellipodium organization	0.04821632592125216	0.04821632592125216	+1	PIK3CA,PIK3R1
GO:0002448	mast cell mediated immunity	0.04821632592125216	0.04821632592125216	+1	PIK3CG,KIT
GO:0010833	telomere maintenance via telomere lengthening	0.04821632592125216	0.04821632592125216	+1	CTNNB1,ATM,ATR
GO:0014743	regulation of muscle hypertrophy	0.04821632592125216	0.04821632592125216	+1	NOTCH1,SMAD4
GO:0002279	mast cell activation involved in immune response	0.04821632592125216	0.04821632592125216	+1	PIK3CG,KIT
GO:0050982	detection of mechanical stimulus	0.04821632592125216	0.04821632592125216	+1	CTNNB1,KIT
GO:0001942	hair follicle development	0.04821632592125216	0.04821632592125216	+1	SOX9,FGFR2
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	0.04821632592125216	0.04821632592125216	+1	NFE2L2,AKT1,LRRK2
GO:0085029	extracellular matrix assembly	0.04821632592125216	0.04821632592125216	+1	NOTCH1,SMAD4
GO:0006403	RNA localization	0.049634551434274414	0.049634551434274414	+1	ATM,SETD2,TGFBR2,ATR
REAC:R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	2.6725442552284753e-15	2.6725442552284753e-15	+1	PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,NOTCH1,CTNNB1,FLT3,NPM1,NRAS,AKT1,BRAF,CDKN1B,HGF,MTOR,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,PPP2R1A,PTPN11,TBL1XR1,NCOR1,SMAD2
REAC:R-HSA-1643685	Disease	2.0253035095949147e-14	2.0253035095949147e-14	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,CTNNB1,DNMT3A,FLT3,KEAP1,CDH1,NFE2L2,NPM1,RUNX1,NRAS,IDH1,MAP2K4,RPL22,AKT1,BRAF,ATM,CDKN1B,HGF,MTOR,TLR4,ATRX,BRCA1,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,BRCA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,SIN3A,HIST1H2BD,PTPN11,TBL1XR1,NCOR1,RPL5,SMAD2,ERCC2,EZH2
REAC:R-HSA-74160	Gene expression (Transcription)	1.4018566648909033e-11	1.4018566648909033e-11	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,NPM1,RUNX1,STK11,KDM6A,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,U2AF1,TET2,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-212436	Generic Transcription Pathway	1.951374822001991e-11	1.951374822001991e-11	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,NPM1,RUNX1,STK11,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-73857	RNA Polymerase II Transcription	7.926690472630348e-11	7.926690472630348e-11	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,NPM1,RUNX1,STK11,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,U2AF1,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-2219528	PI3K/AKT Signaling in Cancer	7.806012520987654e-10	7.806012520987654e-10	+1	PIK3CA,PTEN,EGFR,PIK3R1,FLT3,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PTPN11
REAC:R-HSA-162582	Signal Transduction	3.057321578066265e-9	3.057321578066265e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,NRAS,STK11,AKT1,STAG2,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,MTOR,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,CCND1,SMAD4,USP9X,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,SIN3A,HIST1H2BD,SMC1A,PTPN11,ACVR1B,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,SMAD2,SPOP,AXIN2,RAD21,EZH2
REAC:R-HSA-8939211	ESR-mediated signaling	3.904602711351471e-9	3.904602711351471e-9	+1	PIK3CA,EGFR,PIK3R1,GATA3,RUNX1,NRAS,AKT1,STAG2,CDKN1B,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-9006931	Signaling by Nuclear Receptors	5.303153517855636e-9	5.303153517855636e-9	+1	PIK3CA,EGFR,PIK3R1,GATA3,RUNX1,NRAS,AKT1,STAG2,CDKN1B,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,TBL1XR1,SMC3,NCOR1,RAD21
REAC:R-HSA-1257604	PIP3 activates AKT signaling	3.539094072165429e-8	3.539094072165429e-8	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,FLT3,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PPP2R1A,PTPN11,MECOM,EZH2
REAC:R-HSA-1266738	Developmental Biology	3.744658722332432e-8	3.744658722332432e-8	+1	PIK3CA,EGFR,PIK3R1,NOTCH1,CTNNB1,CDH1,ARHGAP35,CTCF,RUNX1,NRAS,RPL22,CEBPA,KDM6A,EPHA3,AKT1,AJUBA,SOX9,WT1,PRX,FOXA1,EP300,SMAD4,FOXA2,SOX17,CDKN1A,CBFB,HIST1H2BD,PTPN11,ACVR1B,TBL1XR1,ACVR2A,NCOR1,RPL5,SMAD2,EZH2
REAC:R-HSA-2262752	Cellular responses to stress	9.741310798730231e-8	9.741310798730231e-8	+1	TP53,VHL,CDKN2A,RB1,NOTCH1,KEAP1,NFE2L2,IDH1,MAP2K4,RPL22,AKT1,AR,AJUBA,ATM,CDKN1B,MTOR,TLR4,BRCA1,EP300,CDKN1A,ATR,SIN3A,HIST1H2BD,TBL1XR1,NCOR1,RPL5,CDKN2C,EZH2
REAC:R-HSA-9758941	Gastrulation	1.196234702870848e-7	1.196234702870848e-7	+1	NOTCH1,CTNNB1,CDH1,FOXA1,EP300,SMAD4,FOXA2,SOX17,SMAD2
REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	1.196234702870848e-7	1.196234702870848e-7	+1	TP53,KRAS,CDKN2A,NOTCH1,CTNNB1,RUNX1,EP300,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-8953897	Cellular responses to stimuli	1.196234702870848e-7	1.196234702870848e-7	+1	TP53,VHL,CDKN2A,RB1,NOTCH1,KEAP1,NFE2L2,IDH1,MAP2K4,RPL22,AKT1,AR,AJUBA,ATM,CDKN1B,MTOR,TLR4,BRCA1,EP300,CDKN1A,ATR,SIN3A,HIST1H2BD,TBL1XR1,NCOR1,RPL5,CDKN2C,EZH2
REAC:R-HSA-199418	Negative regulation of the PI3K/AKT network	1.9654626833860186e-7	1.9654626833860186e-7	+1	PIK3CA,PTEN,EGFR,PIK3R1,FLT3,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-9703648	Signaling by FLT3 ITD and TKD mutants	1.9700212626473185e-7	1.9700212626473185e-7	+1	PIK3CA,PIK3R1,FLT3,NRAS,CDKN1A,PTPN11
REAC:R-HSA-9006925	Intracellular signaling by second messengers	1.9700212626473185e-7	1.9700212626473185e-7	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,FLT3,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PPP2R1A,PTPN11,MECOM,EZH2
REAC:R-HSA-9823730	Formation of definitive endoderm	1.9700212626473185e-7	1.9700212626473185e-7	+1	CTNNB1,CDH1,SMAD4,FOXA2,SOX17,SMAD2
REAC:R-HSA-8951936	RUNX3 regulates p14-ARF	2.3354519039821977e-7	2.3354519039821977e-7	+1	KRAS,RUNX1,EP300,CCND1,CBFB
REAC:R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	5.263066127667262e-7	5.263066127667262e-7	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-3700989	Transcriptional Regulation by TP53	5.369394754542391e-7	5.369394754542391e-7	+1	TP53,PTEN,CDKN2A,NPM1,STK11,AKT1,ATM,CDKN1B,MTOR,BRCA1,CHEK2,EP300,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,ERCC2
REAC:R-HSA-2990846	SUMOylation	7.302519332374093e-7	7.302519332374093e-7	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	8.782397352199762e-7	8.782397352199762e-7	+1	PIK3CA,EGFR,PIK3R1,FLT3,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-5688426	Deubiquitination	0.0000012343911840898151	0.0000012343911840898151	+1	TP53,PTEN,APC,GATA3,KEAP1,BAP1,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,HIST1H2BD,SMAD2,AXIN2
REAC:R-HSA-6804757	Regulation of TP53 Degradation	0.0000018313221361286535	0.0000018313221361286535	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-9607240	FLT3 Signaling	0.0000018313221361286535	0.0000018313221361286535	+1	PIK3CA,PIK3R1,FLT3,NRAS,AKT1,CDKN1B,PTPN11
REAC:R-HSA-5633007	Regulation of TP53 Activity	0.0000018673946523270343	0.0000018673946523270343	+1	TP53,CDKN2A,STK11,AKT1,ATM,MTOR,BRCA1,CHEK2,EP300,TAF1,PPP2R1A,ATR
REAC:R-HSA-4839726	Chromatin organization	0.000002058499263046571	0.000002058499263046571	+1	ARID1A,PBRM1,DNMT3A,KDM6A,KDM5C,ARID5B,SETD2,EP300,CCND1,HIST1H2BD,NSD1,TBL1XR1,MECOM,NCOR1,EZH2
REAC:R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.000002058499263046571	0.000002058499263046571	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-3247509	Chromatin modifying enzymes	0.000002058499263046571	0.000002058499263046571	+1	ARID1A,PBRM1,DNMT3A,KDM6A,KDM5C,ARID5B,SETD2,EP300,CCND1,HIST1H2BD,NSD1,TBL1XR1,MECOM,NCOR1,EZH2
REAC:R-HSA-1640170	Cell Cycle	0.000004166519674878703	0.000004166519674878703	+1	TP53,CDKN2A,RB1,NPM1,AKT1,STAG2,AJUBA,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CCND1,BRCA2,CDKN1A,PPP2R1A,ATR,HIST1H2BD,SMC1A,SMC3,RAD21,CDKN2C
REAC:R-HSA-9018519	Estrogen-dependent gene expression	0.000005914238975453724	0.000005914238975453724	+1	GATA3,RUNX1,STAG2,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-9682385	FLT3 signaling in disease	0.000005914238975453724	0.000005914238975453724	+1	PIK3CA,PIK3R1,FLT3,NRAS,CDKN1A,PTPN11
REAC:R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.000006266390272137419	0.000006266390272137419	+1	PIK3CA,EGFR,PIK3R1,FLT3,HGF,KIT,PDGFRA,PTPN11
REAC:R-HSA-9614085	FOXO-mediated transcription	0.000006876411095495554	0.000006876411095495554	+1	STK11,AKT1,CDKN1B,EP300,SMAD4,CDKN1A,SIN3A,SMAD2
REAC:R-HSA-69231	Cyclin D associated events in G1	0.000007694475415780297	0.000007694475415780297	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-69236	G1 Phase	0.000007694475415780297	0.000007694475415780297	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-9711123	Cellular response to chemical stress	0.000011686977168745667	0.000011686977168745667	+1	CDKN2A,NOTCH1,KEAP1,NFE2L2,IDH1,AKT1,BRCA1,EP300,CDKN1A,SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-5654741	Signaling by FGFR3	0.000014461212301822523	0.000014461212301822523	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	0.000014461212301822523	0.000014461212301822523	+1	EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
REAC:R-HSA-8848021	Signaling by PTK6	0.000014461212301822523	0.000014461212301822523	+1	EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
REAC:R-HSA-9755511	KEAP1-NFE2L2 pathway	0.000021837988419042185	0.000021837988419042185	+1	CDKN2A,NOTCH1,KEAP1,NFE2L2,IDH1,AKT1,BRCA1,EP300,CDKN1A
REAC:R-HSA-5654743	Signaling by FGFR4	0.00002350571120825602	0.00002350571120825602	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-2470946	Cohesin Loading onto Chromatin	0.0000383556468914756	0.0000383556468914756	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-9673770	Signaling by PDGFRA extracellular domain mutants	0.0000383556468914756	0.0000383556468914756	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
REAC:R-HSA-9673767	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	0.0000383556468914756	0.0000383556468914756	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
REAC:R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.00004026833963533195	0.00004026833963533195	+1	PIK3CA,EGFR,PIK3R1,CTNNB1,FLT3,NRAS,AKT1,BRAF,HGF,MTOR,KIT,PDGFRA,EP300,PPP2R1A,SIN3A,PTPN11,EGR3,NCOR1
REAC:R-HSA-1500620	Meiosis	0.00004099929214956915	0.00004099929214956915	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-5654736	Signaling by FGFR1	0.00004518986858037557	0.00004518986858037557	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-8878166	Transcriptional regulation by RUNX2	0.00004518986858037557	0.00004518986858037557	+1	RB1,RUNX1,AKT1,AR,SOX9,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-5684996	MAPK1/MAPK3 signaling	0.00004518986858037557	0.00004518986858037557	+1	PIK3CA,KRAS,EGFR,NF1,PIK3R1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.00005304400572056921	0.00005304400572056921	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-186763	Downstream signal transduction	0.0000881988045473639	0.0000881988045473639	+1	PIK3CA,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-68884	Mitotic Telophase/Cytokinesis	0.00010524770282848564	0.00010524770282848564	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.00010524770282848564	0.00010524770282848564	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.00010524770282848564	0.00010524770282848564	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-9009391	Extra-nuclear estrogen signaling	0.00012336154140306824	0.00012336154140306824	+1	PIK3CA,EGFR,PIK3R1,NRAS,AKT1,CDKN1B,CCND1
REAC:R-HSA-9796292	Formation of axial mesoderm	0.00013891754487901123	0.00013891754487901123	+1	CTNNB1,FOXA1,FOXA2,SMAD2
REAC:R-HSA-9665348	Signaling by ERBB2 ECD mutants	0.00013891754487901123	0.00013891754487901123	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-8851907	MET activates PI3K/AKT signaling	0.00014641186427510547	0.00014641186427510547	+1	PIK3CA,PIK3R1,HGF
REAC:R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	0.00014641186427510547	0.00014641186427510547	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	0.00014641186427510547	0.00014641186427510547	+1	RUNX1,CBFB,LIFR
REAC:R-HSA-1221632	Meiotic synapsis	0.00014641186427510547	0.00014641186427510547	+1	STAG2,BRCA1,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-5683057	MAPK family signaling cascades	0.00015234036601658872	0.00015234036601658872	+1	PIK3CA,KRAS,EGFR,NF1,PIK3R1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	0.00015234036601658872	0.00015234036601658872	+1	PIK3CA,KRAS,PIK3R1,PIK3CG,PTPN11
REAC:R-HSA-1474165	Reproduction	0.00015836426478763168	0.00015836426478763168	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-5673001	RAF/MAP kinase cascade	0.00015836426478763168	0.00015836426478763168	+1	PIK3CA,KRAS,EGFR,NF1,PIK3R1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A
REAC:R-HSA-1502540	Signaling by Activin	0.0001634750547790797	0.0001634750547790797	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-180292	GAB1 signalosome	0.0002102206898570874	0.0002102206898570874	+1	PIK3CA,EGFR,PIK3R1,PTPN11
REAC:R-HSA-210993	Tie2 Signaling	0.0002102206898570874	0.0002102206898570874	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-9703465	Signaling by FLT3 fusion proteins	0.0002278850137666542	0.0002278850137666542	+1	PIK3CA,PIK3R1,NRAS,CDKN1A
REAC:R-HSA-8878171	Transcriptional regulation by RUNX1	0.0002278850137666542	0.0002278850137666542	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,CCND1,CBFB,SIN3A,HIST1H2BD,PTPN11,LIFR
REAC:R-HSA-5655332	Signaling by FGFR3 in disease	0.0002278850137666542	0.0002278850137666542	+1	PIK3CA,PIK3R1,NRAS,FGFR3
REAC:R-HSA-9669938	Signaling by KIT in disease	0.0002278850137666542	0.0002278850137666542	+1	PIK3CA,PIK3R1,NRAS,KIT
REAC:R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.0002278850137666542	0.0002278850137666542	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-157118	Signaling by NOTCH	0.0002278850137666542	0.0002278850137666542	+1	TP53,EGFR,NOTCH1,RUNX1,AKT1,ELF3,EP300,CCND1,HIST1H2BD,TBL1XR1,NCOR1
REAC:R-HSA-9670439	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	0.0002278850137666542	0.0002278850137666542	+1	PIK3CA,PIK3R1,NRAS,KIT
REAC:R-HSA-9617828	FOXO-mediated transcription of cell cycle genes	0.0002278850137666542	0.0002278850137666542	+1	CDKN1B,SMAD4,CDKN1A,SMAD2
REAC:R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.0002278850137666542	0.0002278850137666542	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	0.0002278850137666542	0.0002278850137666542	+1	RB1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-8934593	Regulation of RUNX1 Expression and Activity	0.0002278850137666542	0.0002278850137666542	+1	RUNX1,CCND1,CBFB,PTPN11
REAC:R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.0002278850137666542	0.0002278850137666542	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-9659787	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	0.0002278850137666542	0.0002278850137666542	+1	RB1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-8941855	RUNX3 regulates CDKN1A transcription	0.0002278850137666542	0.0002278850137666542	+1	TP53,SMAD4,CDKN1A
REAC:R-HSA-2559583	Cellular Senescence	0.00024246582585470968	0.00024246582585470968	+1	TP53,CDKN2A,RB1,MAP2K4,ATM,CDKN1B,CDKN1A,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-9006936	Signaling by TGFB family members	0.0002524147291273133	0.0002524147291273133	+1	EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,NCOR1,SMAD2
REAC:R-HSA-5654708	Downstream signaling of activated FGFR3	0.000277706026000661	0.000277706026000661	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-9671555	Signaling by PDGFR in disease	0.000277706026000661	0.000277706026000661	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
REAC:R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	0.00028040610628078574	0.00028040610628078574	+1	ARID1A,PBRM1,RUNX1,EP300,CBFB
REAC:R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.00031586002289513024	0.00031586002289513024	+1	TP53,ATM,BRCA1,ATR,CDK12,ERCC2
REAC:R-HSA-69242	S Phase	0.00033227870577318336	0.00033227870577318336	+1	RB1,AKT1,STAG2,CDKN1B,CCND1,CDKN1A,SMC1A,SMC3,RAD21
REAC:R-HSA-6804760	Regulation of TP53 Activity through Methylation	0.00033408093115119115	0.00033408093115119115	+1	TP53,ATM,CHEK2,EP300
REAC:R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.0003410148186175275	0.0003410148186175275	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.0003410148186175275	0.0003410148186175275	+1	TP53,STK11,ATM,BRCA1,CHEK2,TAF1,ATR
REAC:R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.0003410148186175275	0.0003410148186175275	+1	EGFR,NPM1,KIT,EP300,CDKN1A
REAC:R-HSA-9675126	Diseases of mitotic cell cycle	0.0003410148186175275	0.0003410148186175275	+1	RB1,CDKN1B,ATRX,CCND1,CDKN1A
REAC:R-HSA-1433557	Signaling by SCF-KIT	0.0003789334165778811	0.0003789334165778811	+1	PIK3CA,PIK3R1,NRAS,KIT,PTPN11
REAC:R-HSA-112399	IRS-mediated signalling	0.0003789334165778811	0.0003789334165778811	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-5654738	Signaling by FGFR2	0.0003789334165778811	0.0003789334165778811	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5693532	DNA Double-Strand Break Repair	0.00040310418872801075	0.00040310418872801075	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-166520	Signaling by NTRKs	0.0004307505524040541	0.0004307505524040541	+1	PIK3CA,PIK3R1,NRAS,BRAF,EP300,PPP2R1A,PTPN11,EGR3
REAC:R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	0.0004345660411868467	0.0004345660411868467	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-69563	p53-Dependent G1 DNA Damage Response	0.0004345660411868467	0.0004345660411868467	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-9006115	Signaling by NTRK2 (TRKB)	0.0004457646619587167	0.0004457646619587167	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-9664565	Signaling by ERBB2 KD Mutants	0.0004457646619587167	0.0004457646619587167	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-388841	Costimulation by the CD28 family	0.00046024276189934123	0.00046024276189934123	+1	PIK3CA,PIK3R1,AKT1,MTOR,PPP2R1A,PTPN11
REAC:R-HSA-69615	G1/S DNA Damage Checkpoints	0.0004961365680060058	0.0004961365680060058	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.0004984469218819334	0.0004984469218819334	+1	APC,CTNNB1,AKT1,SOX9,SOX17
REAC:R-HSA-1227990	Signaling by ERBB2 in Cancer	0.0005072040754316465	0.0005072040754316465	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.0005072040754316465	0.0005072040754316465	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-5654687	Downstream signaling of activated FGFR1	0.0005072040754316465	0.0005072040754316465	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-5654716	Downstream signaling of activated FGFR4	0.0005072040754316465	0.0005072040754316465	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-2428928	IRS-related events triggered by IGF1R	0.0005304351543808128	0.0005304351543808128	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-2428924	IGF1R signaling cascade	0.0005304351543808128	0.0005304351543808128	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-5689880	Ub-specific processing proteases	0.0005461856152546292	0.0005461856152546292	+1	TP53,PTEN,GATA3,KEAP1,AR,SMAD4,USP9X,HIST1H2BD,SMAD2,AXIN2
REAC:R-HSA-1643713	Signaling by EGFR in Cancer	0.0005690499454915809	0.0005690499454915809	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.0005690499454915809	0.0005690499454915809	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-5654696	Downstream signaling of activated FGFR2	0.0005690499454915809	0.0005690499454915809	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-1181150	Signaling by NODAL	0.0005690499454915809	0.0005690499454915809	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-9006335	Signaling by Erythropoietin	0.0005690499454915809	0.0005690499454915809	+1	PIK3CA,PIK3R1,NRAS,PIK3CG
REAC:R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	0.0006072635058754763	0.0006072635058754763	+1	CDKN2A,STAG2,BRCA1,SMC1A,SMC3,RAD21
REAC:R-HSA-5655291	Signaling by FGFR4 in disease	0.0006125093166970109	0.0006125093166970109	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-74751	Insulin receptor signalling cascade	0.0006146819509773021	0.0006146819509773021	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-597592	Post-translational protein modification	0.0006295215772215742	0.0006295215772215742	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,DNMT3A,KEAP1,NFE2L2,BAP1,NPM1,STAG2,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,CDKN1A,B4GALT3,SIN3A,HIST1H2BD,SMC1A,SMC3,SMAD2,AXIN2,RAD21
REAC:R-HSA-9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	0.0006508001524545788	0.0006508001524545788	+1	EGFR,AKT1,CDKN1B,CCND1
REAC:R-HSA-212165	Epigenetic regulation of gene expression	0.0006650322805268994	0.0006650322805268994	+1	DNMT3A,KDM6A,TET2,EP300,SF3B1,SIN3A,HIST1H2BD,ERCC2,EZH2
REAC:R-HSA-190236	Signaling by FGFR	0.0006650322805268994	0.0006650322805268994	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-69278	Cell Cycle, Mitotic	0.0006650322805268994	0.0006650322805268994	+1	TP53,CDKN2A,RB1,AKT1,STAG2,AJUBA,CDKN1B,EP300,CCND1,CDKN1A,PPP2R1A,HIST1H2BD,SMC1A,SMC3,RAD21,CDKN2C
REAC:R-HSA-1227986	Signaling by ERBB2	0.0006650322805268994	0.0006650322805268994	+1	PIK3CA,EGFR,PIK3R1,NRAS,AKT1
REAC:R-HSA-1912422	Pre-NOTCH Expression and Processing	0.0007046944866499756	0.0007046944866499756	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-9707616	Heme signaling	0.0007137143552192096	0.0007137143552192096	+1	NFE2L2,TLR4,EP300,TBL1XR1,NCOR1
REAC:R-HSA-201556	Signaling by ALK	0.0007284324766266342	0.0007284324766266342	+1	PIK3CA,PIK3R1,EP300,SIN3A
REAC:R-HSA-453279	Mitotic G1 phase and G1/S transition	0.0007415355064198558	0.0007415355064198558	+1	CDKN2A,RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-177929	Signaling by EGFR	0.0007672465163666436	0.0007672465163666436	+1	PIK3CA,EGFR,PIK3R1,NRAS,PTPN11
REAC:R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.0007672465163666436	0.0007672465163666436	+1	TP53,PIK3R1,GATA3,AKT1,HGF,CCND1,CDKN1A
REAC:R-HSA-9702518	STAT5 activation downstream of FLT3 ITD mutants	0.0007799565311007562	0.0007799565311007562	+1	FLT3,CDKN1A,PTPN11
REAC:R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.0007828656932635521	0.0007828656932635521	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.0008174848143860939	0.0008174848143860939	+1	AKT1,CDKN1B,MTOR,CDKN1A
REAC:R-HSA-187037	Signaling by NTRK1 (TRKA)	0.0008178699540857289	0.0008178699540857289	+1	PIK3CA,PIK3R1,NRAS,BRAF,EP300,PPP2R1A,EGR3
REAC:R-HSA-5693606	DNA Double Strand Break Response	0.0008178699540857289	0.0008178699540857289	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.0008178699540857289	0.0008178699540857289	+1	TP53,NPM1,CDKN1B,EP300,CDKN1A
REAC:R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.0008717233630821065	0.0008717233630821065	+1	TP53,RB1,ATM,CDKN1B,CDKN1A,HIST1H2BD
REAC:R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.0008827125954742829	0.0008827125954742829	+1	EP300,SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-9005895	Pervasive developmental disorders	0.0009856085265703303	0.0009856085265703303	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9675151	Disorders of Developmental Biology	0.0009856085265703303	0.0009856085265703303	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	0.0009856085265703303	0.0009856085265703303	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9697154	Disorders of Nervous System Development	0.0009856085265703303	0.0009856085265703303	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.0011841094209484688	0.0011841094209484688	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-5619507	Activation of HOX genes during differentiation	0.0011841094209484688	0.0011841094209484688	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.0011841094209484688	0.0011841094209484688	+1	SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-186797	Signaling by PDGF	0.0012018813370081875	0.0012018813370081875	+1	PIK3CA,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-1236394	Signaling by ERBB4	0.0012018813370081875	0.0012018813370081875	+1	PIK3CA,EGFR,PIK3R1,NRAS,NCOR1
REAC:R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.0012538858349715255	0.0012538858349715255	+1	PIK3CA,PIK3R1,PIK3CG
REAC:R-HSA-8941326	RUNX2 regulates bone development	0.00130368147194719	0.00130368147194719	+1	RB1,AR,SMAD4,CBFB
REAC:R-HSA-1280215	Cytokine Signaling in Immune system	0.0013868545385548696	0.0013868545385548696	+1	TP53,PIK3CA,KRAS,PIK3R1,GATA3,FLT3,NRAS,MAP2K4,AKT1,PIK3CG,CDKN1B,HGF,CCND1,CDKN1A,PPP2R1A,EIF4A2,PTPN11,LIFR
REAC:R-HSA-1226099	Signaling by FGFR in disease	0.0013927652046567278	0.0013927652046567278	+1	PIK3CA,PIK3R1,NRAS,FGFR2,FGFR3
REAC:R-HSA-9616222	Transcriptional regulation of granulopoiesis	0.0014318708124860706	0.0014318708124860706	+1	RUNX1,CEBPA,EP300,CDKN1A,CBFB,HIST1H2BD
REAC:R-HSA-389356	CD28 co-stimulation	0.0014481420477240798	0.0014481420477240798	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-5654710	PI-3K cascade:FGFR3	0.0015480012946766	0.0015480012946766	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-1963642	PI3K events in ERBB2 signaling	0.0015480012946766	0.0015480012946766	+1	PIK3CA,EGFR,PIK3R1
REAC:R-HSA-5663205	Infectious disease	0.0015537134674410943	0.0015537134674410943	+1	VHL,EGFR,RB1,CTNNB1,KEAP1,CDH1,NFE2L2,NPM1,RUNX1,MAP2K4,RPL22,AKT1,EP300,SMAD4,TAF1,HIST1H2BD,PTPN11,TBL1XR1,NCOR1,RPL5,ERCC2,EZH2
REAC:R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.0015694198870549565	0.0015694198870549565	+1	EP300,SMAD4,USP9X,TGFBR2,NCOR1,SMAD2
REAC:R-HSA-9818749	Regulation of NFE2L2 gene expression	0.0016755517511895515	0.0016755517511895515	+1	NOTCH1,NFE2L2
REAC:R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	0.0016755517511895515	0.0016755517511895515	+1	SMAD4,SMAD2
REAC:R-HSA-9753510	Signaling by RAS GAP mutants	0.0016755517511895515	0.0016755517511895515	+1	KRAS,NRAS
REAC:R-HSA-9649913	RAS GTPase cycle mutants	0.0016755517511895515	0.0016755517511895515	+1	KRAS,NRAS
REAC:R-HSA-9753512	Signaling by RAS GTPase mutants	0.0016755517511895515	0.0016755517511895515	+1	KRAS,NRAS
REAC:R-HSA-8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	0.0016755517511895515	0.0016755517511895515	+1	RUNX1,CBFB
REAC:R-HSA-9818025	NFE2L2 regulating TCA cycle genes	0.0016755517511895515	0.0016755517511895515	+1	NFE2L2,IDH1
REAC:R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	0.0016755517511895515	0.0016755517511895515	+1	SMAD4,SMAD2
REAC:R-HSA-3304347	Loss of Function of SMAD4 in Cancer	0.0016755517511895515	0.0016755517511895515	+1	SMAD4,SMAD2
REAC:R-HSA-2559585	Oncogene Induced Senescence	0.001704853235654928	0.001704853235654928	+1	TP53,CDKN2A,RB1,CDKN2C
REAC:R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.0017792448690923661	0.0017792448690923661	+1	TP53,CDKN1B,CDKN1A
REAC:R-HSA-198323	AKT phosphorylates targets in the cytosol	0.0017792448690923661	0.0017792448690923661	+1	AKT1,CDKN1B,CDKN1A
REAC:R-HSA-9034015	Signaling by NTRK3 (TRKC)	0.0017792448690923661	0.0017792448690923661	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-1295596	Spry regulation of FGF signaling	0.0017792448690923661	0.0017792448690923661	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-9824446	Viral Infection Pathways	0.0018002901624012723	0.0018002901624012723	+1	VHL,EGFR,RB1,KEAP1,NFE2L2,NPM1,RUNX1,RPL22,AKT1,EP300,SMAD4,TAF1,HIST1H2BD,PTPN11,TBL1XR1,NCOR1,RPL5,ERCC2,EZH2
REAC:R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.0018003676065619838	0.0018003676065619838	+1	PIK3CA,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-69473	G2/M DNA damage checkpoint	0.0018003676065619838	0.0018003676065619838	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-9709570	Impaired BRCA2 binding to RAD51	0.0020424250065452653	0.0020424250065452653	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-114604	GPVI-mediated activation cascade	0.0020424250065452653	0.0020424250065452653	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
REAC:R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	0.0020653415031917956	0.0020653415031917956	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-73894	DNA Repair	0.0020653415031917956	0.0020653415031917956	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,EP300,BRCA2,ATR,HIST1H2BD,ERCC2
REAC:R-HSA-5654689	PI-3K cascade:FGFR1	0.0020653415031917956	0.0020653415031917956	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	0.0020653415031917956	0.0020653415031917956	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	0.0020653415031917956	0.0020653415031917956	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	0.0020653415031917956	0.0020653415031917956	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-4839743	Signaling by CTNNB1 phospho-site mutants	0.0020653415031917956	0.0020653415031917956	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5339716	Signaling by GSK3beta mutants	0.0020653415031917956	0.0020653415031917956	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	0.0021616247468462693	0.0021616247468462693	+1	RB1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-109704	PI3K Cascade	0.0021616247468462693	0.0021616247468462693	+1	PIK3CA,PIK3R1,FLT3,PTPN11
REAC:R-HSA-201681	TCF dependent signaling in response to WNT	0.0023545774063933153	0.0023545774063933153	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
REAC:R-HSA-5655253	Signaling by FGFR2 in disease	0.0023805645559368026	0.0023805645559368026	+1	PIK3CA,PIK3R1,NRAS,FGFR2
REAC:R-HSA-69620	Cell Cycle Checkpoints	0.002741791819108998	0.002741791819108998	+1	TP53,CDKN2A,ATM,CDKN1B,BRCA1,CHEK2,CDKN1A,PPP2R1A,ATR,HIST1H2BD
REAC:R-HSA-8865999	MET activates PTPN11	0.002741791819108998	0.002741791819108998	+1	HGF,PTPN11
REAC:R-HSA-194138	Signaling by VEGF	0.002741791819108998	0.002741791819108998	+1	PIK3CA,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-5654720	PI-3K cascade:FGFR4	0.002741791819108998	0.002741791819108998	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-9682706	Replication of the SARS-CoV-1 genome	0.002741791819108998	0.002741791819108998	+1	VHL,RB1
REAC:R-HSA-9754189	Germ layer formation at gastrulation	0.002741791819108998	0.002741791819108998	+1	CTNNB1,SMAD4,SMAD2
REAC:R-HSA-9694682	SARS-CoV-2 Genome Replication and Transcription	0.002741791819108998	0.002741791819108998	+1	VHL,RB1
REAC:R-HSA-9679514	SARS-CoV-1 Genome Replication and Transcription	0.002741791819108998	0.002741791819108998	+1	VHL,RB1
REAC:R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.002741791819108998	0.002741791819108998	+1	TGFBR2,SMAD2
REAC:R-HSA-9694686	Replication of the SARS-CoV-2 genome	0.002741791819108998	0.002741791819108998	+1	VHL,RB1
REAC:R-HSA-69895	Transcriptional  activation of  cell cycle inhibitor p21 	0.002741791819108998	0.002741791819108998	+1	TP53,CDKN1A
REAC:R-HSA-8853884	Transcriptional Regulation by VENTX	0.002741791819108998	0.002741791819108998	+1	TP53,CDKN2A,CTNNB1,CCND1
REAC:R-HSA-69560	Transcriptional activation of p53 responsive genes  	0.002741791819108998	0.002741791819108998	+1	TP53,CDKN1A
REAC:R-HSA-3656532	TGFBR1 KD Mutants in Cancer	0.002741791819108998	0.002741791819108998	+1	TGFBR2,SMAD2
REAC:R-HSA-186712	Regulation of beta-cell development	0.002741791819108998	0.002741791819108998	+1	NOTCH1,AKT1,EP300,FOXA2
REAC:R-HSA-196299	Beta-catenin phosphorylation cascade	0.002741791819108998	0.002741791819108998	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.0029607406403521926	0.0029607406403521926	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-9675136	Diseases of DNA Double-Strand Break Repair	0.0032104585967069658	0.0032104585967069658	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-5654695	PI-3K cascade:FGFR2	0.0032104585967069658	0.0032104585967069658	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-9701190	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	0.0032104585967069658	0.0032104585967069658	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-74752	Signaling by Insulin receptor	0.003502601287963237	0.003502601287963237	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-392499	Metabolism of proteins	0.003667310832708943	0.003667310832708943	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,CTNNB1,DNMT3A,KEAP1,NFE2L2,BAP1,NPM1,RPL22,STAG2,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,CDKN1A,B4GALT3,SIN3A,HIST1H2BD,EIF4A2,SMC1A,SMC3,RPL5,SMAD2,AXIN2,RAD21
REAC:R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.003800363162558002	0.003800363162558002	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-6806834	Signaling by MET	0.0041507798790400546	0.0041507798790400546	+1	PIK3CA,PIK3R1,NRAS,HGF,PTPN11
REAC:R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	0.004271606172943192	0.004271606172943192	+1	RUNX1,CBFB
REAC:R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.004271606172943192	0.004271606172943192	+1	CTNNB1,EP300
REAC:R-HSA-389513	CTLA4 inhibitory signaling	0.004271606172943192	0.004271606172943192	+1	AKT1,PPP2R1A,PTPN11
REAC:R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	0.004271606172943192	0.004271606172943192	+1	TGFBR2,SMAD2
REAC:R-HSA-9759194	Nuclear events mediated by NFE2L2	0.004565114482425779	0.004565114482425779	+1	CDKN2A,NOTCH1,NFE2L2,IDH1,EP300
REAC:R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.004759102306645291	0.004759102306645291	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-69202	Cyclin E associated events during G1/S transition 	0.0056686657367436815	0.0056686657367436815	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-2559580	Oxidative Stress Induced Senescence	0.005700124023799172	0.005700124023799172	+1	TP53,CDKN2A,MAP2K4,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-9603381	Activated NTRK3 signals through PI3K	0.005960144946782249	0.005960144946782249	+1	PIK3CA,PIK3R1
REAC:R-HSA-9793380	Formation of paraxial mesoderm	0.005960144946782249	0.005960144946782249	+1	NOTCH1,CTNNB1,EP300
REAC:R-HSA-9028335	Activated NTRK2 signals through PI3K	0.005960144946782249	0.005960144946782249	+1	PIK3CA,PIK3R1
REAC:R-HSA-9645135	STAT5 Activation	0.005960144946782249	0.005960144946782249	+1	FLT3,PTPN11
REAC:R-HSA-8939245	RUNX1 regulates transcription of genes involved in BCR signaling	0.005960144946782249	0.005960144946782249	+1	RUNX1,CBFB
REAC:R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.005960144946782249	0.005960144946782249	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-5654732	Negative regulation of FGFR3 signaling	0.005960144946782249	0.005960144946782249	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.005960144946782249	0.005960144946782249	+1	RB1,AR,CBFB
REAC:R-HSA-9022537	Loss of MECP2 binding ability to the NCoR/SMRT complex	0.005960144946782249	0.005960144946782249	+1	TBL1XR1,NCOR1
REAC:R-HSA-8857538	PTK6 promotes HIF1A stabilization	0.005960144946782249	0.005960144946782249	+1	EGFR,LRRK2
REAC:R-HSA-8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	0.005960144946782249	0.005960144946782249	+1	RUNX1,CBFB
REAC:R-HSA-8939256	RUNX1 regulates transcription of genes involved in WNT signaling	0.005960144946782249	0.005960144946782249	+1	RUNX1,CBFB
REAC:R-HSA-6802953	RAS signaling downstream of NF1 loss-of-function variants	0.005960144946782249	0.005960144946782249	+1	NF1,NRAS
REAC:R-HSA-8849470	PTK6 Regulates Cell Cycle	0.005960144946782249	0.005960144946782249	+1	CDKN1B,CCND1
REAC:R-HSA-8931987	RUNX1 regulates estrogen receptor mediated transcription	0.005960144946782249	0.005960144946782249	+1	RUNX1,CBFB
REAC:R-HSA-9675135	Diseases of DNA repair	0.006032005651224183	0.006032005651224183	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-9709603	Impaired BRCA2 binding to PALB2	0.006707324302285069	0.006707324302285069	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.00692743240639989	0.00692743240639989	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-109581	Apoptosis	0.007195513010602381	0.007195513010602381	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,AKT1,TLR4
REAC:R-HSA-69206	G1/S Transition	0.007251569266604592	0.007251569266604592	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A
REAC:R-HSA-9701192	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	0.007326394527020593	0.007326394527020593	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-9701193	Defective homologous recombination repair (HRR) due to PALB2 loss of function	0.007326394527020593	0.007326394527020593	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-2424491	DAP12 signaling	0.007326394527020593	0.007326394527020593	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	0.007326394527020593	0.007326394527020593	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	0.007326394527020593	0.007326394527020593	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-8941332	RUNX2 regulates genes involved in cell migration	0.007770169970198126	0.007770169970198126	+1	AKT1,CBFB
REAC:R-HSA-2179392	EGFR Transactivation by Gastrin	0.007770169970198126	0.007770169970198126	+1	EGFR,NRAS
REAC:R-HSA-5654726	Negative regulation of FGFR1 signaling	0.008125840382700691	0.008125840382700691	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-449147	Signaling by Interleukins	0.008935701319320312	0.008935701319320312	+1	TP53,PIK3CA,PIK3R1,GATA3,MAP2K4,AKT1,HGF,CCND1,CDKN1A,PPP2R1A,PTPN11,LIFR
REAC:R-HSA-5218920	VEGFR2 mediated vascular permeability	0.008935701319320312	0.008935701319320312	+1	CTNNB1,AKT1,MTOR
REAC:R-HSA-5654733	Negative regulation of FGFR4 signaling	0.008935701319320312	0.008935701319320312	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.008935701319320312	0.008935701319320312	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.00899664041485288	0.00899664041485288	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-69541	Stabilization of p53	0.00899664041485288	0.00899664041485288	+1	TP53,CDKN2A,ATM,CHEK2
REAC:R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.00899664041485288	0.00899664041485288	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.00899664041485288	0.00899664041485288	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.00899664041485288	0.00899664041485288	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.00899664041485288	0.00899664041485288	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-5693538	Homology Directed Repair	0.009069937393544038	0.009069937393544038	+1	ATM,BRCA1,POLQ,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-6807070	PTEN Regulation	0.009069937393544038	0.009069937393544038	+1	TP53,PTEN,AKT1,MTOR,MECOM,EZH2
REAC:R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	0.009169834954754007	0.009169834954754007	+1	RUNX1,EP300,CBFB,SIN3A,HIST1H2BD
REAC:R-HSA-8851805	MET activates RAS signaling	0.009470088416990109	0.009470088416990109	+1	NRAS,HGF
REAC:R-HSA-9818028	NFE2L2 regulates pentose phosphate pathway genes	0.009470088416990109	0.009470088416990109	+1	NFE2L2,EP300
REAC:R-HSA-9678108	SARS-CoV-1 Infection	0.009470088416990109	0.009470088416990109	+1	VHL,RB1,NPM1,RUNX1,EP300,SMAD4
REAC:R-HSA-5654727	Negative regulation of FGFR2 signaling	0.009470088416990109	0.009470088416990109	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-350054	Notch-HLH transcription pathway	0.009470088416990109	0.009470088416990109	+1	NOTCH1,TBL1XR1,NCOR1
REAC:R-HSA-8951430	RUNX3 regulates WNT signaling	0.009470088416990109	0.009470088416990109	+1	CTNNB1,CCND1
REAC:R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.009470088416990109	0.009470088416990109	+1	CTNNB1,AXIN2
REAC:R-HSA-8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	0.009470088416990109	0.009470088416990109	+1	RUNX1,CBFB
REAC:R-HSA-8943724	Regulation of PTEN gene transcription	0.009731762045458971	0.009731762045458971	+1	TP53,MTOR,MECOM,EZH2
REAC:R-HSA-8986944	Transcriptional Regulation by MECP2	0.009731762045458971	0.009731762045458971	+1	PTEN,SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.010368505868178913	0.010368505868178913	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.011146328125144387	0.011146328125144387	+1	SMAD4,SIN3A,SMAD2
REAC:R-HSA-9022692	Regulation of MECP2 expression and activity	0.011146328125144387	0.011146328125144387	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-6804758	Regulation of TP53 Activity through Acetylation	0.011146328125144387	0.011146328125144387	+1	TP53,AKT1,EP300
REAC:R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.011329627139615894	0.011329627139615894	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-9707564	Cytoprotection by HMOX1	0.011414812094576824	0.011414812094576824	+1	NFE2L2,SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.011535359892134991	0.011535359892134991	+1	CTNNB1,CDH1
REAC:R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	0.011535359892134991	0.011535359892134991	+1	NRAS,PTPN11
REAC:R-HSA-1250342	PI3K events in ERBB4 signaling	0.011535359892134991	0.011535359892134991	+1	PIK3CA,PIK3R1
REAC:R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.011535359892134991	0.011535359892134991	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-198203	PI3K/AKT activation	0.011535359892134991	0.011535359892134991	+1	PIK3CA,PIK3R1
REAC:R-HSA-6811555	PI5P Regulates TP53 Acetylation	0.011535359892134991	0.011535359892134991	+1	TP53,EP300
REAC:R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.011872524697212852	0.011872524697212852	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-9645723	Diseases of programmed cell death	0.01190676487947334	0.01190676487947334	+1	TP53,CDKN2A,DNMT3A,HIST1H2BD,EZH2
REAC:R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.01190676487947334	0.01190676487947334	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-5655302	Signaling by FGFR1 in disease	0.012874372872201372	0.012874372872201372	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.013375643401664722	0.013375643401664722	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	0.013818798302363763	0.013818798302363763	+1	RUNX1,CBFB
REAC:R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling 	0.013818798302363763	0.013818798302363763	+1	TP53,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-9701898	STAT3 nuclear events downstream of ALK signaling	0.013818798302363763	0.013818798302363763	+1	EP300,SIN3A
REAC:R-HSA-5673000	RAF activation	0.013818798302363763	0.013818798302363763	+1	NRAS,BRAF,PPP2R1A
REAC:R-HSA-166166	MyD88-independent TLR4 cascade 	0.013818798302363763	0.013818798302363763	+1	TP53,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-4791275	Signaling by WNT in cancer	0.014856006406942188	0.014856006406942188	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.014856006406942188	0.014856006406942188	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-5357801	Programmed Cell Death	0.014856006406942188	0.014856006406942188	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,AKT1,TLR4
REAC:R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.0148784651250397	0.0148784651250397	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.01573891101342632	0.01573891101342632	+1	CDKN2A,CDKN1B,CDKN1A,HIST1H2BD,CDKN2C
REAC:R-HSA-5693537	Resolution of D-Loop Structures	0.01592246973731674	0.01592246973731674	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-2172127	DAP12 interactions	0.01592246973731674	0.01592246973731674	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-179812	GRB2 events in EGFR signaling	0.01603063098779185	0.01603063098779185	+1	EGFR,NRAS
REAC:R-HSA-9690406	Transcriptional regulation of testis differentiation	0.01603063098779185	0.01603063098779185	+1	SOX9,WT1
REAC:R-HSA-195721	Signaling by WNT	0.01603063098779185	0.01603063098779185	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
REAC:R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.01603063098779185	0.01603063098779185	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-3214841	PKMTs methylate histone lysines	0.01603063098779185	0.01603063098779185	+1	SETD2,NSD1,MECOM,EZH2
REAC:R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.01603063098779185	0.01603063098779185	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-351906	Apoptotic cleavage of cell adhesion  proteins	0.01603063098779185	0.01603063098779185	+1	CTNNB1,CDH1
REAC:R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.016753903874179688	0.016753903874179688	+1	EP300,SMAD4,SMAD2
REAC:R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	0.016753903874179688	0.016753903874179688	+1	EP300,TBL1XR1,NCOR1
REAC:R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.017468986800851814	0.017468986800851814	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-1980143	Signaling by NOTCH1	0.017468986800851814	0.017468986800851814	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.017468986800851814	0.017468986800851814	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-111465	Apoptotic cleavage of cellular proteins	0.017819968849449357	0.017819968849449357	+1	APC,CTNNB1,CDH1
REAC:R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.017819968849449357	0.017819968849449357	+1	ATM,BRCA1,ATR
REAC:R-HSA-168898	Toll-like Receptor Cascades	0.0180716604570379	0.0180716604570379	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.018407647123992277	0.018407647123992277	+1	TP53,ATM
REAC:R-HSA-1433617	Regulation of signaling by NODAL	0.018407647123992277	0.018407647123992277	+1	ACVR1B,ACVR2A
REAC:R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	0.018407647123992277	0.018407647123992277	+1	POLQ,BRCA2
REAC:R-HSA-180336	SHC1 events in EGFR signaling	0.018407647123992277	0.018407647123992277	+1	EGFR,NRAS
REAC:R-HSA-8853659	RET signaling	0.018798952269540026	0.018798952269540026	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-69481	G2/M Checkpoints	0.018798952269540026	0.018798952269540026	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-5689896	Ovarian tumor domain proteases	0.02015951029624009	0.02015951029624009	+1	TP53,PTEN,APC
REAC:R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.021223249843993854	0.021223249843993854	+1	RB1,PPP2R1A
REAC:R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	0.021223249843993854	0.021223249843993854	+1	ARHGAP35,NRAS
REAC:R-HSA-1963640	GRB2 events in ERBB2 signaling	0.021223249843993854	0.021223249843993854	+1	EGFR,NRAS
REAC:R-HSA-3214858	RMTs methylate histone arginines	0.022066832428701274	0.022066832428701274	+1	ARID1A,PBRM1,DNMT3A,CCND1
REAC:R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.022079446326941362	0.022079446326941362	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
REAC:R-HSA-165159	MTOR signalling	0.022698249385805426	0.022698249385805426	+1	STK11,AKT1,MTOR
REAC:R-HSA-3899300	SUMOylation of transcription cofactors	0.022698249385805426	0.022698249385805426	+1	NPM1,EP300,SIN3A
REAC:R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.02360354760710356	0.02360354760710356	+1	APC,PPP2R1A
REAC:R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.02360354760710356	0.02360354760710356	+1	TP53,AKT1
REAC:R-HSA-8941856	RUNX3 regulates NOTCH signaling	0.02360354760710356	0.02360354760710356	+1	NOTCH1,EP300
REAC:R-HSA-4839748	Signaling by AMER1 mutants	0.02360354760710356	0.02360354760710356	+1	APC,PPP2R1A
REAC:R-HSA-4839744	Signaling by APC mutants	0.02360354760710356	0.02360354760710356	+1	APC,PPP2R1A
REAC:R-HSA-5675221	Negative regulation of MAPK pathway	0.02360354760710356	0.02360354760710356	+1	NRAS,BRAF,PPP2R1A
REAC:R-HSA-4839735	Signaling by AXIN mutants	0.02360354760710356	0.02360354760710356	+1	APC,PPP2R1A
REAC:R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.02360354760710356	0.02360354760710356	+1	APC,PPP2R1A
REAC:R-HSA-5654706	FRS-mediated FGFR3 signaling	0.02360354760710356	0.02360354760710356	+1	NRAS,PTPN11
REAC:R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.02360354760710356	0.02360354760710356	+1	APC,PPP2R1A
REAC:R-HSA-1500931	Cell-Cell communication	0.0242435469632174	0.0242435469632174	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,PTPN11
REAC:R-HSA-5628897	TP53 Regulates Metabolic Genes	0.02429672213844909	0.02429672213844909	+1	TP53,PTEN,AKT1,MTOR
REAC:R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.02429672213844909	0.02429672213844909	+1	KRAS,NRAS,BRAF
REAC:R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.02429672213844909	0.02429672213844909	+1	EGFR,KIT
REAC:R-HSA-6802949	Signaling by RAS mutants	0.02429672213844909	0.02429672213844909	+1	KRAS,NRAS,BRAF
REAC:R-HSA-1483255	PI Metabolism	0.02429672213844909	0.02429672213844909	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.02429672213844909	0.02429672213844909	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	0.02429672213844909	0.02429672213844909	+1	EP300,TBL1XR1,NCOR1
REAC:R-HSA-6802957	Oncogenic MAPK signaling	0.02429672213844909	0.02429672213844909	+1	KRAS,NF1,NRAS,BRAF
REAC:R-HSA-9649948	Signaling downstream of RAS mutants	0.02429672213844909	0.02429672213844909	+1	KRAS,NRAS,BRAF
REAC:R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.02429672213844909	0.02429672213844909	+1	ATM,BRCA1,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	0.02429672213844909	0.02429672213844909	+1	EP300,SMAD4
REAC:R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.02429672213844909	0.02429672213844909	+1	KRAS,NRAS,BRAF
REAC:R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.02429672213844909	0.02429672213844909	+1	CEBPA,EP300,TBL1XR1,NCOR1
REAC:R-HSA-912446	Meiotic recombination	0.025180750026110137	0.025180750026110137	+1	ATM,BRCA1,BRCA2,HIST1H2BD
REAC:R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.025484066792532015	0.025484066792532015	+1	NOTCH1,EP300
REAC:R-HSA-9818027	NFE2L2 regulating anti-oxidant/detoxification enzymes	0.025484066792532015	0.025484066792532015	+1	NFE2L2,EP300
REAC:R-HSA-5654693	FRS-mediated FGFR1 signaling	0.025484066792532015	0.025484066792532015	+1	NRAS,PTPN11
REAC:R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.025484066792532015	0.025484066792532015	+1	TP53,RB1
REAC:R-HSA-936964	Activation of IRF3, IRF7 mediated by TBK1, IKBKE	0.025484066792532015	0.025484066792532015	+1	TLR4,PTPN11
REAC:R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	0.025484066792532015	0.025484066792532015	+1	PIK3CA,PIK3R1
REAC:R-HSA-9614657	FOXO-mediated transcription of cell death genes	0.025484066792532015	0.025484066792532015	+1	STK11,EP300
REAC:R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.025484066792532015	0.025484066792532015	+1	EGFR,NRAS
REAC:R-HSA-3371556	Cellular response to heat stress	0.025632612455656914	0.025632612455656914	+1	ATM,MTOR,EP300,ATR
REAC:R-HSA-9609690	HCMV Early Events	0.025731724071370365	0.025731724071370365	+1	EGFR,HIST1H2BD,TBL1XR1,NCOR1,EZH2
REAC:R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.026453982296844262	0.026453982296844262	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-9012852	Signaling by NOTCH3	0.027951652483037926	0.027951652483037926	+1	EGFR,NOTCH1,EP300
REAC:R-HSA-432142	Platelet sensitization by LDL	0.028356574472329466	0.028356574472329466	+1	PPP2R1A,PTPN11
REAC:R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.02843267845961162	0.02843267845961162	+1	CTNNB1,EP300,HIST1H2BD,AXIN2
REAC:R-HSA-1250196	SHC1 events in ERBB2 signaling	0.03117905149080128	0.03117905149080128	+1	EGFR,NRAS
REAC:R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	0.03117905149080128	0.03117905149080128	+1	EGFR,NRAS
REAC:R-HSA-3232118	SUMOylation of transcription factors	0.03117905149080128	0.03117905149080128	+1	TP53,CDKN2A
REAC:R-HSA-1368082	RORA activates gene expression	0.03117905149080128	0.03117905149080128	+1	EP300,TBL1XR1
REAC:R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.03117905149080128	0.03117905149080128	+1	TP53,EP300
REAC:R-HSA-5654712	FRS-mediated FGFR4 signaling	0.03117905149080128	0.03117905149080128	+1	NRAS,PTPN11
REAC:R-HSA-75153	Apoptotic execution phase	0.03218141357035775	0.03218141357035775	+1	APC,CTNNB1,CDH1
REAC:R-HSA-3214842	HDMs demethylate histones	0.03218141357035775	0.03218141357035775	+1	KDM6A,KDM5C,ARID5B
REAC:R-HSA-9692914	SARS-CoV-1-host interactions	0.033416837111846	0.033416837111846	+1	NPM1,RUNX1,EP300,SMAD4
REAC:R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.034058055012927614	0.034058055012927614	+1	TP53,MAP3K1,MAP2K4,PPP2R1A
REAC:R-HSA-5654700	FRS-mediated FGFR2 signaling	0.034058055012927614	0.034058055012927614	+1	NRAS,PTPN11
REAC:R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.034058055012927614	0.034058055012927614	+1	TP53,MAP3K1,MAP2K4,PPP2R1A
REAC:R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.034058055012927614	0.034058055012927614	+1	TP53,MAP3K1,MAP2K4,PPP2R1A
REAC:R-HSA-8978934	Metabolism of cofactors	0.034058055012927614	0.034058055012927614	+1	IDH1,AKT1
REAC:R-HSA-8876384	Listeria monocytogenes entry into host cells	0.034058055012927614	0.034058055012927614	+1	CTNNB1,CDH1
REAC:R-HSA-210745	Regulation of gene expression in beta cells	0.034058055012927614	0.034058055012927614	+1	AKT1,FOXA2
REAC:R-HSA-9679506	SARS-CoV Infections	0.0344178109117274	0.0344178109117274	+1	VHL,RB1,KEAP1,NFE2L2,NPM1,RUNX1,AKT1,EP300,SMAD4,PTPN11
REAC:R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.03472347797753697	0.03472347797753697	+1	IDH2,TBL1XR1,NCOR1
REAC:R-HSA-9700206	Signaling by ALK in cancer	0.03472347797753697	0.03472347797753697	+1	PIK3CA,PIK3R1,NPM1
REAC:R-HSA-9725370	Signaling by ALK fusions and activated point mutants	0.03472347797753697	0.03472347797753697	+1	PIK3CA,PIK3R1,NPM1
REAC:R-HSA-5693607	Processing of DNA double-strand break ends	0.03486165168247008	0.03486165168247008	+1	ATM,BRCA1,ATR,HIST1H2BD
REAC:R-HSA-8941858	Regulation of RUNX3 expression and activity	0.03626106932901256	0.03626106932901256	+1	CDKN2A,EP300,CBFB
REAC:R-HSA-109606	Intrinsic Pathway for Apoptosis	0.03626106932901256	0.03626106932901256	+1	TP53,CDKN2A,AKT1
REAC:R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.03652025953024077	0.03652025953024077	+1	TP53,ATM
REAC:R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	0.03652025953024077	0.03652025953024077	+1	NOTCH1,EP300
REAC:R-HSA-5621575	CD209 (DC-SIGN) signaling	0.03652025953024077	0.03652025953024077	+1	NRAS,EP300
REAC:R-HSA-912631	Regulation of signaling by CBL	0.0399291259220263	0.0399291259220263	+1	PIK3CA,PIK3R1
REAC:R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.0399291259220263	0.0399291259220263	+1	TP53,NPM1
REAC:R-HSA-113510	E2F mediated regulation of DNA replication	0.04187413292753596	0.04187413292753596	+1	RB1,PPP2R1A
REAC:R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.04187413292753596	0.04187413292753596	+1	SMAD4,SMAD2
REAC:R-HSA-9609646	HCMV Infection	0.0435436525222601	0.0435436525222601	+1	EGFR,HIST1H2BD,TBL1XR1,NCOR1,EZH2
REAC:R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	0.04518542860974026	0.04518542860974026	+1	CDKN1B,CCND1,CDKN1A
REAC:R-HSA-373753	Nephrin family interactions	0.04518542860974026	0.04518542860974026	+1	PIK3CA,PIK3R1
REAC:R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.04701578592825392	0.04701578592825392	+1	EP300,PPP2R1A,EGR3
REAC:R-HSA-3371571	HSF1-dependent transactivation	0.048265646398377014	0.048265646398377014	+1	MTOR,EP300
REAC:R-HSA-2173788	Downregulation of TGF-beta receptor signaling	0.048265646398377014	0.048265646398377014	+1	TGFBR2,SMAD2
REAC:R-HSA-6783589	Interleukin-6 family signaling	0.048265646398377014	0.048265646398377014	+1	PTPN11,LIFR
REAC:R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	0.048265646398377014	0.048265646398377014	+1	NOTCH1,EP300
REAC:R-HSA-9648002	RAS processing	0.048265646398377014	0.048265646398377014	+1	KRAS,NRAS
REAC:R-HSA-9734009	Defective Intrinsic Pathway for Apoptosis	0.048265646398377014	0.048265646398377014	+1	TP53,CDKN2A
REAC:R-HSA-168256	Immune System	0.04969672050076572	0.04969672050076572	+1	TP53,PIK3CA,PTEN,VHL,KRAS,PIK3R1,GATA3,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,NRAS,IDH1,MAP2K4,AKT1,PIK3CG,CDKN1B,HGF,MTOR,TLR4,EP300,CCND1,CDKN1A,PPP2R1A,EIF4A2,PTPN11,LIFR
WP:WP4674	Head and neck squamous cell carcinoma	2.357725944198663e-25	2.357725944198663e-25	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,PIK3R1,CDKN2A,RB1,NOTCH1,CTNNB1,KEAP1,NFE2L2,NRAS,STK11,AKT1,AJUBA,PIK3CG,MTOR,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A
WP:WP2261	Glioblastoma signaling pathways	2.023816953712193e-24	2.023816953712193e-24	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NRAS,MAP2K4,AKT1,BRAF,PIK3CG,ATM,CDKN1B,BRCA1,PDGFRA,EP300,FGFR2,CCND1,BRCA2,CDKN1A,CDKN2C
WP:WP3651	Pathways affected in adenoid cystic carcinoma	4.11441409600573e-19	4.11441409600573e-19	+1	TP53,PIK3CA,PTEN,ARID1A,NOTCH1,FBXW7,CEBPA,KDM6A,AKT1,ATM,ARID5B,ATRX,BRCA1,CHEK2,SETD2,EP300,SMC1A,NSD1,NCOR1
WP:WP4155	Endometrial cancer	2.0559623656892386e-16	2.0559623656892386e-16	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,PIK3R1,CTNNB1,CDH1,NRAS,AKT1,BRAF,FGFR2,CCND1,FGFR3,CDKN1A,AXIN2
WP:WP4262	Breast cancer pathway	2.587388271832118e-15	2.587388271832118e-15	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,PIK3R1,RB1,NOTCH1,CTNNB1,NRAS,AKT1,BRAF,ATM,MTOR,BRCA1,KIT,CCND1,BRCA2,CDKN1A,ATR,AXIN2
WP:WP4685	Melanoma	1.6526865281059437e-14	1.6526865281059437e-14	+1	TP53,PIK3CA,PTEN,KRAS,NF1,PIK3R1,CDKN2A,RB1,CDH1,NRAS,AKT1,BRAF,ERBB4,KIT,CCND1,CDKN1A
WP:WP4263	Pancreatic adenocarcinoma pathway	1.1269051773280757e-12	1.1269051773280757e-12	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CDKN2A,RB1,AKT1,BRAF,MTOR,CCND1,SMAD4,BRCA2,TGFBR2,CDKN1A,SMAD2
WP:WP5087	Pleural mesothelioma	1.1271120098323657e-12	1.1271120098323657e-12	+1	TP53,PIK3CA,PTEN,APC,EGFR,CDKN2A,CTNNB1,MAP3K1,FLT3,CDH1,BAP1,MAP2K4,KDM6A,AKT1,AJUBA,PIK3CG,ATM,HGF,MTOR,BRCA1,KIT,SETD2,PDGFRA,FGFR2,CCND1,FGFR3,ASXL1,SOX17,CDKN1A,EZH2
WP:WP2263	Androgen receptor network in prostate cancer	1.8060260462317705e-12	1.8060260462317705e-12	+1	TP53,PIK3CA,PTEN,ARID1A,RB1,AKT1,AR,ATM,HGF,MTOR,BRCA1,FOXA1,CHEK2,CCND1,ATR,PTPN11,SMAD2
WP:WP710	DNA damage response only ATM dependent 	1.9021930760674828e-12	1.9021930760674828e-12	+1	TP53,PIK3CA,PTEN,APC,KRAS,PIK3R1,CDKN2A,CTNNB1,MAP3K1,NRAS,AKT1,PIK3CG,ATM,CDKN1B,CCND1,SMAD4,CDKN1A
WP:WP2870	Extracellular vesicle mediated signaling in recipient cells	2.2544055421653885e-12	2.2544055421653885e-12	+1	APC,KRAS,EGFR,CTNNB1,NRAS,AKT1,HGF,MTOR,SMAD4,TGFBR2,SMAD2
WP:WP2828	Bladder cancer	2.270709951473319e-12	2.270709951473319e-12	+1	TP53,KRAS,EGFR,PIK3R1,CDKN2A,RB1,CDH1,NRAS,BRAF,CCND1,FGFR3,CDKN1A
WP:WP4806	EGFR tyrosine kinase inhibitor resistance	5.613246971025945e-12	5.613246971025945e-12	+1	PIK3CA,PTEN,KRAS,EGFR,NF1,PIK3R1,NRAS,AKT1,BRAF,HGF,MTOR,PDGFRA,FGFR2,CCND1,FGFR3
WP:WP179	Cell cycle	6.009686084717482e-12	6.009686084717482e-12	+1	TP53,CDKN2A,RB1,STAG2,ATM,CDKN1B,CHEK2,EP300,CCND1,SMAD4,CDKN1A,ATR,SMC1A,SMC3,SMAD2,RAD21,CDKN2C
WP:WP673	ErbB signaling pathway	1.9095879740969723e-10	1.9095879740969723e-10	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,NRAS,MAP2K4,AKT1,BRAF,CDKN1B,ERBB4,MTOR,CCND1,CDKN1A
WP:WP1971	Integrated cancer pathway	1.9095879740969723e-10	1.9095879740969723e-10	+1	TP53,PTEN,RB1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CDKN1A,ATR,SMAD2
WP:WP5322	CKAP4 signaling pathway map	2.945619579553967e-10	2.945619579553967e-10	+1	TP53,PIK3CA,PTEN,EGFR,FBXW7,CTNNB1,CDH1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,SMAD4,TGFBR2
WP:WP4172	PI3K Akt signaling pathway	1.1147922522325246e-9	1.1147922522325246e-9	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,PIK3R1,FLT3,NRAS,STK11,AKT1,PIK3CG,CDKN1B,HGF,MTOR,TLR4,BRCA1,KIT,PDGFRA,FGFR2,CCND1,FGFR3,CDKN1A,PPP2R1A
WP:WP5293	Acute myeloid leukemia	1.311293156283697e-9	1.311293156283697e-9	+1	PIK3CA,KRAS,PIK3R1,FLT3,RUNX1,NRAS,CEBPA,AKT1,BRAF,MTOR,KIT,CCND1
WP:WP138	Androgen receptor signaling pathway	1.311293156283697e-9	1.311293156283697e-9	+1	PTEN,EGFR,PIK3R1,RB1,CTNNB1,AKT1,AR,BRCA1,EP300,CCND1,SMAD4,SIN3A,NCOR1
WP:WP4255	Non small cell lung cancer	2.517284052894927e-9	2.517284052894927e-9	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CDKN2A,RB1,NRAS,AKT1,BRAF,CCND1,CDKN1A
WP:WP4216	Chromosomal and microsatellite instability in colorectal cancer 	2.720688433070487e-9	2.720688433070487e-9	+1	TP53,APC,KRAS,CTNNB1,AKT1,BRAF,CCND1,SMAD4,TGFBR2,CDKN1A,SMAD2,AXIN2
WP:WP3981	miRNA regulation of prostate cancer signaling pathways	2.720688433070487e-9	2.720688433070487e-9	+1	TP53,PIK3CA,KRAS,CTNNB1,AR,CDKN1B,MTOR,CCND1,CDKN1A
WP:WP5300	TROP2 regulatory signaling	3.3285435262383643e-9	3.3285435262383643e-9	+1	PTEN,EGFR,PIK3R1,CDKN2A,RB1,NOTCH1,CTNNB1,CDH1,CDKN1B,CCND1
WP:WP3844	PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer	3.3724067179877113e-9	3.3724067179877113e-9	+1	PIK3CA,PTEN,KRAS,PIK3R1,NRAS,AKT1,PIK3CG,CDKN1B,MTOR
WP:WP4659	Gastrin signaling pathway	3.671147250451456e-9	3.671147250451456e-9	+1	PIK3CA,KRAS,EGFR,PIK3R1,CDKN2A,CTNNB1,CDH1,AKT1,CDKN1B,MTOR,KIT,CCND1,CDKN1A,PTPN11
WP:WP2857	Mesodermal commitment pathway	9.916868050851351e-9	9.916868050851351e-9	+1	GATA3,NFE2L2,TBX3,KDM6A,ARID5B,FOXA1,SETD2,CCND1,SMAD4,FOXA2,SOX17,PHF6,ACVR2A,SMAD2,AXIN2
WP:WP4666	Hepatitis B infection	1.5400653459516636e-8	1.5400653459516636e-8	+1	PIK3CA,KRAS,PIK3R1,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,TLR4,EP300,SMAD4,TGFBR2,CDKN1A,EGR3,SMAD2
WP:WP707	DNA damage response	1.864200210861589e-8	1.864200210861589e-8	+1	TP53,RB1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR,SMC1A
WP:WP3584	MECP2 and associated Rett syndrome	3.365577544911269e-8	3.365577544911269e-8	+1	PTEN,NF1,CTCF,AKT1,MTOR,TET2,TAF1,SIN3A,SMC3,NCOR1,EZH2
WP:WP3931	Embryonic stem cell pluripotency pathways	4.496393646827415e-8	4.496393646827415e-8	+1	PTEN,APC,EGFR,CTNNB1,AKT1,BRAF,MTOR,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11,LIFR
WP:WP2586	Aryl hydrocarbon receptor pathway	8.880151203653934e-8	8.880151203653934e-8	+1	KRAS,EGFR,NF1,RB1,NFE2L2,NRAS,CDKN1B,EP300,CDKN1A
WP:WP3932	Focal adhesion PI3K Akt mTOR signaling pathway	1.4360737066093935e-7	1.4360737066093935e-7	+1	PIK3CA,PTEN,KRAS,EGFR,PIK3R1,NRAS,STK11,AKT1,PIK3CG,CDKN1B,HGF,MTOR,FOXA1,KIT,PDGFRA,FGFR2,FGFR3,CDKN1A,PPP2R1A
WP:WP4018	Clear cell renal cell carcinoma pathways	1.561458162422779e-7	1.561458162422779e-7	+1	PTEN,VHL,PBRM1,EGFR,BAP1,AKT1,KDM5C,MTOR,SETD2,PDGFRA,EP300
WP:WP3611	Photodynamic therapy induced AP 1 survival signaling	1.7673677576209048e-7	1.7673677576209048e-7	+1	TP53,EGFR,CDKN2A,RB1,NFE2L2,MAP2K4,PDGFRA,CCND1,CDKN1A
WP:WP4483	Relationship between inflammation COX 2 and EGFR	2.825154613079944e-7	2.825154613079944e-7	+1	PIK3CA,KRAS,EGFR,NRAS,AKT1,BRAF,PIK3CG
WP:WP1530	miRNA regulation of DNA damage response	3.9114879007750204e-7	3.9114879007750204e-7	+1	TP53,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR,SMC1A
WP:WP3959	DNA IR double strand breaks and cellular response via ATM	3.9114879007750204e-7	3.9114879007750204e-7	+1	TP53,CDKN2A,ATM,BRCA1,CHEK2,BRCA2,ATR,SMC1A,SMC3
WP:WP4541	Hippo Merlin signaling dysregulation	5.507266010696142e-7	5.507266010696142e-7	+1	KRAS,EGFR,CTNNB1,FLT3,CDH1,NRAS,AJUBA,KIT,PDGFRA,FGFR2,CCND1,FGFR3
WP:WP4205	MET in type 1 papillary renal cell carcinoma	6.022562309317851e-7	6.022562309317851e-7	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,BRAF,HGF,CDKN1A,PTPN11
WP:WP3657	Hematopoietic stem cell gene regulation by GABP alpha beta complex	0.00000168197214841123	0.00000168197214841123	+1	PTEN,DNMT3A,FLT3,ATM,EP300,SMAD4
WP:WP5118	SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome	0.0000016997527971310212	0.0000016997527971310212	+1	ATM,BRCA1,SMC1A,SMC3,RAD21
WP:WP4239	Epithelial to mesenchymal transition in colorectal cancer	0.0000017198891301620327	0.0000017198891301620327	+1	TP53,PIK3CA,KRAS,PIK3R1,NOTCH1,CTNNB1,CDH1,MAP2K4,AKT1,SMAD4,TGFBR2,SMAD2,EZH2
WP:WP3680	Physico chemical features and toxicity associated pathways	0.0000017437408389032148	0.0000017437408389032148	+1	APC,EGFR,CTNNB1,MAP2K4,AKT1,PIK3CG,CDKN1B,ERBB4,CDKN1A
WP:WP3303	RAC1 PAK1 p38 MMP2 pathway	0.0000022209248066905053	0.0000022209248066905053	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CTNNB1,NRAS,AKT1,PTPN11
WP:WP4539	Synaptic signaling pathways associated with autism spectrum disorder	0.000002339494181355886	0.000002339494181355886	+1	PIK3CA,PTEN,KRAS,NF1,PIK3R1,NRAS,AKT1,MTOR
WP:WP51	Regulation of actin cytoskeleton	0.000005007389363105485	0.000005007389363105485	+1	PIK3CA,APC,KRAS,EGFR,PIK3R1,ARHGAP35,NRAS,BRAF,PIK3CG,PDGFRA,FGFR2,FGFR3
WP:WP4540	Hippo signaling regulation pathways	0.000005202541623847016	0.000005202541623847016	+1	EGFR,CTNNB1,FLT3,CDH1,MTOR,KIT,PDGFRA,FGFR2,FGFR3,SMAD2
WP:WP4223	Ras signaling	0.00000667066950750523	0.00000667066950750523	+1	PIK3CA,KRAS,EGFR,NF1,PIK3R1,FLT3,NRAS,AKT1,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
WP:WP3658	Wnt beta catenin signaling pathway in leukemia	0.00000768306911475423	0.00000768306911475423	+1	APC,CTNNB1,FLT3,AKT1,CCND1,AXIN2
WP:WP366	TGF beta signaling pathway	0.00000935641627234693	0.00000935641627234693	+1	TP53,PIK3R1,MAP2K4,AKT1,EP300,CCND1,SMAD4,TGFBR2,CDKN1A,SIN3A,SMAD2
WP:WP5353	A network map of Macrophage stimulating protein MSP signaling	0.00000980802624355024	0.00000980802624355024	+1	TP53,PTEN,PIK3R1,CTNNB1,CDH1,AKT1,MTOR,PDGFRA,SMAD2
WP:WP45	G1 to S cell cycle control	0.000014373752116532155	0.000014373752116532155	+1	TP53,CDKN2A,RB1,ATM,CDKN1B,CCND1,CDKN1A,CDKN2C
WP:WP4566	Translation inhibitors in chronically activated PDGFRA cells	0.000016710063617127914	0.000016710063617127914	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PIK3CG,MTOR,EIF4A2
WP:WP1403	AMP activated protein kinase signaling	0.000019755291194272576	0.000019755291194272576	+1	TP53,PIK3CA,PIK3R1,STK11,AKT1,PIK3CG,MTOR,CDKN1A
WP:WP4838	Regucalcin in proximal tubule epithelial kidney cells	0.0000207962498241172	0.0000207962498241172	+1	PIK3CA,AKT1,BRAF,MTOR,SMAD4,SMAD2
WP:WP382	MAPK signaling pathway	0.00002956588233332934	0.00002956588233332934	+1	TP53,KRAS,EGFR,NF1,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,LRRK2,FGFR2,FGFR3,TGFBR2,MAPK8IP1
WP:WP3676	BDNF TrkB signaling	0.00002956588233332934	0.00002956588233332934	+1	KRAS,NRAS,AKT1,BRAF,PIK3CG,MTOR
WP:WP4658	Small cell lung cancer	0.0000328214668911327	0.0000328214668911327	+1	TP53,PIK3CA,PTEN,PIK3R1,RB1,AKT1,CDKN1B,CCND1,CDKN1A
WP:WP5117	Cohesin complex Cornelia de Lange syndrome	0.00003433593677592915	0.00003433593677592915	+1	APC,STAG2,PPP2R1A,SMC1A,SMC3,RAD21
WP:WP61	Notch signaling pathway	0.00003465276703308374	0.00003465276703308374	+1	PIK3R1,NOTCH1,FBXW7,AKT1,MTOR,EP300,NCOR1
WP:WP3927	BMP signaling in eyelid development	0.00003515657128924477	0.00003515657128924477	+1	EGFR,NOTCH1,MAP3K1,FGFR2,SMAD4
WP:WP5144	NRP1 triggered signaling pathways in pancreatic cancer 	0.000038243176422669584	0.000038243176422669584	+1	EGFR,AKT1,CDKN1B,HGF,SMAD4,TGFBR2,SMAD2
WP:WP399	Wnt signaling pathway and pluripotency	0.00004249461350824529	0.00004249461350824529	+1	TP53,APC,CTNNB1,MAP2K4,LRRK2,EP300,CCND1,PPP2R1A,AXIN2
WP:WP2374	Oncostatin M signaling pathway	0.000053172665650304325	0.000053172665650304325	+1	KRAS,PIK3R1,AKT1,CDKN1B,MTOR,PTPN11,LIFR
WP:WP3646	Hepatitis C and hepatocellular carcinoma	0.000053172665650304325	0.000053172665650304325	+1	TP53,AKT1,BRCA1,CCND1,SMAD4,CDKN1A,PTPN11
WP:WP4879	Overlap between signal transduction pathways contributing to LMNA laminopathies	0.000059070786078305654	0.000059070786078305654	+1	APC,RB1,NOTCH1,CTNNB1,CEBPA,CDKN1A,SMAD2
WP:WP2032	Thyroid stimulating hormone TSH signaling pathway	0.00006547977837227836	0.00006547977837227836	+1	PIK3CA,PIK3R1,RB1,AKT1,BRAF,CDKN1B,MTOR
WP:WP2516	ATM signaling pathway	0.0000799251788829363	0.0000799251788829363	+1	TP53,ATM,BRCA1,CHEK2,CDKN1A,SMC1A
WP:WP5191	Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution	0.00008461937525139843	0.00008461937525139843	+1	PIK3CA,AKT1,PIK3CG,MTOR
WP:WP2853	Endoderm differentiation	0.00010959731955555047	0.00010959731955555047	+1	APC,NOTCH1,CTNNB1,FOXA1,SMAD4,FOXA2,SOX17,PHF6,SMAD2,EZH2
WP:WP5098	T cell activation SARS CoV 2	0.00011835395558730759	0.00011835395558730759	+1	TP53,PTEN,PIK3R1,CDKN2A,AKT1,MTOR,CCND1,CDKN1A
WP:WP2446	Retinoblastoma gene in cancer	0.00012687534051816847	0.00012687534051816847	+1	TP53,RB1,CDKN1B,CCND1,CDKN1A,SIN3A,SMC1A,SMC3
WP:WP4787	Osteoblast differentiation and related diseases	0.00014192003100354174	0.00014192003100354174	+1	PIK3CA,PIK3R1,NOTCH1,CTNNB1,PIK3CG,SOX9,FGFR2,SMAD4,FGFR3
WP:WP3878	ATM signaling in development and disease 	0.0001479274351823084	0.0001479274351823084	+1	STK11,ATM,MTOR,CHEK2,ATR,SMC1A
WP:WP4240	Regulation of sister chromatid separation at the metaphase anaphase transition	0.00015243209264852135	0.00015243209264852135	+1	APC,SMC1A,SMC3,RAD21
WP:WP3969	H19 action Rb E2F1 signaling and CDK Beta catenin activity	0.00015243209264852135	0.00015243209264852135	+1	RB1,CTNNB1,CDH1,CCND1
WP:WP5158	Urotensin II mediated signaling pathway	0.00018190785057223665	0.00018190785057223665	+1	PTEN,EGFR,CTNNB1,AKT1,EP300,PTPN11,SMAD2
WP:WP2572	Primary focal segmental glomerulosclerosis FSGS 	0.00023742298983717207	0.00023742298983717207	+1	NOTCH1,CTNNB1,AKT1,CDKN1B,WT1,TLR4,CDKN1A
WP:WP4186	Somatroph axis GH and its relationship to dietary restriction and aging	0.00024333717726416569	0.00024333717726416569	+1	PTEN,AKT1,MTOR
WP:WP2253	Pilocytic astrocytoma	0.00024333717726416569	0.00024333717726416569	+1	NF1,BRAF,PTPN11
WP:WP395	IL 4 signaling pathway	0.0002472453310892274	0.0002472453310892274	+1	PIK3CA,PIK3R1,CEBPA,AKT1,EP300,PTPN11
WP:WP5373	Role of hypoxia angiogenesis and FGF pathway in OA chondrocyte hypertrophy	0.0002472453310892274	0.0002472453310892274	+1	PIK3CA,VHL,AKT1,SOX9,FGFR2,FGFR3
WP:WP2839	Hair follicle development organogenesis part 2 of 3	0.000294065676570317	0.000294065676570317	+1	CTNNB1,CDH1,PDGFRA,FGFR2,CCND1
WP:WP306	Focal adhesion	0.000294065676570317	0.000294065676570317	+1	PIK3CA,PTEN,EGFR,PIK3R1,CTNNB1,ARHGAP35,AKT1,BRAF,HGF,PDGFRA,CCND1
WP:WP3286	Copper homeostasis	0.0002992640833531564	0.0002992640833531564	+1	TP53,PIK3CA,PTEN,APC,AKT1,CCND1
WP:WP4872	MAP3K1 role in promoting and blocking gonadal determination	0.0003076055769794546	0.0003076055769794546	+1	CTNNB1,MAP3K1,SOX9,FGFR2
WP:WP3859	TGF beta signaling in thyroid cells for epithelial mesenchymal transition	0.0003076055769794546	0.0003076055769794546	+1	CDH1,AKT1,SMAD4,SMAD2
WP:WP1544	MicroRNAs in cardiomyocyte hypertrophy	0.00032246620670057597	0.00032246620670057597	+1	PIK3CA,PIK3R1,CTNNB1,MAP2K4,AKT1,PIK3CG,MTOR,FGFR2
WP:WP422	MAPK cascade	0.00032354609133708337	0.00032354609133708337	+1	KRAS,MAP3K1,NRAS,MAP2K4,BRAF
WP:WP2813	Mammary gland development pathway Embryonic development Stage 1 of 4 	0.00037859243331154796	0.00037859243331154796	+1	CDH1,AKT1,ERBB4,CCND1
WP:WP4016	DNA IR damage and cellular response via ATR	0.0004367463316396787	0.0004367463316396787	+1	TP53,ATM,BRCA1,CHEK2,BRCA2,ATR,SMC1A
WP:WP1742	TP53 network	0.0004645005262206302	0.0004645005262206302	+1	TP53,CDKN2A,ATM,CDKN1A
WP:WP3850	Factors and pathways affecting insulin like growth factor IGF1 Akt signaling	0.00047686537757358365	0.00047686537757358365	+1	PTEN,AKT1,PIK3CG,MTOR,SMAD2
WP:WP34	Ovarian infertility	0.0005342752097685356	0.0005342752097685356	+1	AKT1,ATM,CDKN1B,MTOR,NCOR1
WP:WP127	IL 5 signaling pathway	0.0005342752097685356	0.0005342752097685356	+1	KRAS,PIK3R1,AKT1,PIK3CG,PTPN11
WP:WP4191	Caloric restriction and aging	0.0005524140848652963	0.0005524140848652963	+1	TP53,AKT1,MTOR
WP:WP3585	Cytosine methylation	0.0005524140848652963	0.0005524140848652963	+1	IDH1,TET2,IDH2
WP:WP4871	Kisspeptin kisspeptin receptor system in the ovary	0.0006701642066070894	0.0006701642066070894	+1	PIK3CA,KRAS,NRAS,AKT1,PIK3CG
WP:WP4549	Fragile X syndrome	0.0008336105290396107	0.0008336105290396107	+1	PTEN,KRAS,NF1,CDKN2A,AKT1,BRAF,MTOR,PTPN11
WP:WP4790	FGF23 signaling in hypophosphatemic rickets and related disorders	0.0009383003118498596	0.0009383003118498596	+1	FGFR2,CCND1,FGFR3,CDKN1A
WP:WP437	EGF EGFR signaling pathway	0.0009980967415329058	0.0009980967415329058	+1	PTEN,KRAS,EGFR,PIK3R1,MAP3K1,AKT1,BRAF,MTOR,PTPN11
WP:WP1539	Angiogenesis	0.0010824611329518878	0.0010824611329518878	+1	PIK3CA,AKT1,PDGFRA,FGFR2
WP:WP481	Insulin signaling	0.0010824611329518878	0.0010824611329518878	+1	PIK3CA,PTEN,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG,MTOR,PTPN11
WP:WP3879	4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression	0.001251593273260205	0.001251593273260205	+1	PIK3CA,PIK3R1,AKT1,MTOR
WP:WP4842	Mammalian disorder of sexual development	0.001251593273260205	0.001251593273260205	+1	CTNNB1,SOX9,WT1,FGFR2
WP:WP5216	Warburg effect modulated by deubiquitinating enzymes and their substrates	0.0014505752123636078	0.0014505752123636078	+1	PIK3CA,VHL,AKT1,MTOR
WP:WP2064	Neural crest differentiation	0.0014782014995399022	0.0014782014995399022	+1	NOTCH1,CTNNB1,CDH1,SOX9,FGFR2,FGFR3,AXIN2
WP:WP363	Wnt signaling pathway	0.0014782014995399022	0.0014782014995399022	+1	APC,CTNNB1,AKT1,MTOR,CCND1
WP:WP1591	Heart development	0.0014782014995399022	0.0014782014995399022	+1	NOTCH1,CTNNB1,SMAD4,FOXA2,PTPN11
WP:WP2037	Prolactin signaling pathway	0.0016695869765035612	0.0016695869765035612	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,MTOR,PTPN11
WP:WP5055	Burn wound healing	0.0017795686020198823	0.0017795686020198823	+1	TP53,AKT1,HGF,TLR4,FGFR2,FGFR3
WP:WP5382	TGF Smad signaling pathway	0.0018111474003845646	0.0018111474003845646	+1	SMAD4,TGFBR2,SMAD2
WP:WP5351	Kleefstra syndrome	0.002080123471645851	0.002080123471645851	+1	ARID1A,BAP1,KDM6A,ASXL1
WP:WP3972	PDGFR beta pathway	0.002080123471645851	0.002080123471645851	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4
WP:WP2406	Cardiac progenitor differentiation	0.0024424017261914146	0.0024424017261914146	+1	NOTCH1,KIT,PDGFRA,FOXA2,SOX17
WP:WP304	Kit receptor signaling pathway	0.0024424017261914146	0.0024424017261914146	+1	PIK3R1,AKT1,KIT,EP300,PTPN11
WP:WP3982	miRNA regulation of p53 pathway in prostate cancer	0.0025971574088547323	0.0025971574088547323	+1	TP53,PTEN,ATM,CHEK2
WP:WP195	IL 1 signaling pathway	0.0025971574088547323	0.0025971574088547323	+1	PIK3R1,MAP3K1,MAP2K4,AKT1,PTPN11
WP:WP4204	Tumor suppressor activity of SMARCB1	0.0025971574088547323	0.0025971574088547323	+1	ARID1A,CDKN2A,RB1,EZH2
WP:WP5192	Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids	0.0027228184863094538	0.0027228184863094538	+1	PIK3CA,AKT1,MTOR
WP:WP4582	Cancer immunotherapy by CTLA4 blockade	0.0027228184863094538	0.0027228184863094538	+1	PIK3CA,PIK3R1,PTPN11
WP:WP560	TGF beta receptor signaling	0.0027360907113112153	0.0027360907113112153	+1	CTNNB1,EP300,SMAD4,TGFBR2,SMAD2
WP:WP2795	Cardiac hypertrophic response	0.0027360907113112153	0.0027360907113112153	+1	MAP3K1,MAP2K4,AKT1,MTOR,FGFR2
WP:WP3995	Prion disease pathway	0.0027886281271494485	0.0027886281271494485	+1	CTCF,EP300,SMC3,RAD21
WP:WP2431	Spinal cord injury	0.0027886281271494485	0.0027886281271494485	+1	TP53,EGFR,RB1,SOX9,CDKN1B,TLR4,CCND1
WP:WP2817	Mammary gland development pathway Pregnancy and lactation Stage 3 of 4 	0.003068334445283621	0.003068334445283621	+1	EGFR,CEBPA,ERBB4,CCND1
WP:WP4874	CAMKK2 pathway	0.003068334445283621	0.003068334445283621	+1	NFE2L2,MTOR,EP300,SMC1A
WP:WP244	Alpha 6 beta 4 signaling pathway	0.003068334445283621	0.003068334445283621	+1	PIK3R1,AKT1,MTOR,PTPN11
WP:WP3	Transcriptional activation by NRF2 in response to phytochemicals	0.0031636071203350337	0.0031636071203350337	+1	PIK3CA,KEAP1,NFE2L2
WP:WP254	Apoptosis	0.0032895251630444475	0.0032895251630444475	+1	TP53,PIK3R1,CDKN2A,MAP3K1,MAP2K4,AKT1
WP:WP5358	JAK STAT signaling in the regulation of Beta cells	0.0032895251630444475	0.0032895251630444475	+1	KRAS,NRAS,AKT1,MTOR
WP:WP4241	Type 2 papillary renal cell carcinoma	0.0032895251630444475	0.0032895251630444475	+1	VHL,SETD2,EP300,CDKN1A
WP:WP313	Hepatocyte growth factor receptor signaling	0.0032895251630444475	0.0032895251630444475	+1	PIK3CA,PTEN,HGF,PTPN11
WP:WP2840	Hair follicle development cytodifferentiation part 3 of 3	0.0032895251630444475	0.0032895251630444475	+1	EGFR,GATA3,NOTCH1,CTNNB1,SOX9,SMAD4
WP:WP4816	TGF beta receptor signaling in skeletal dysplasias	0.003418710077213191	0.003418710077213191	+1	CTNNB1,EP300,SMAD4,TGFBR2,SMAD2
WP:WP5236	Markers of kidney cell lineage	0.003418710077213191	0.003418710077213191	+1	NOTCH1,CTNNB1,WT1,KIT,AXIN2
WP:WP5053	Development of ureteric collection system	0.0036641886249953242	0.0036641886249953242	+1	GATA3,CTNNB1,WT1,FGFR2,CCND1
WP:WP5180	DYRK1A involvement regarding cell proliferation in brain development	0.004221581014659725	0.004221581014659725	+1	TP53,NOTCH1,CDKN1B,MTOR,CCND1
WP:WP3678	Amplification and expansion of oncogenic pathways as metastatic traits	0.004276477655299762	0.004276477655299762	+1	VHL,NOTCH1,PIK3CG
WP:WP3874	Canonical and non canonical TGF B signaling	0.004276477655299762	0.004276477655299762	+1	SMAD4,TGFBR2,SMAD2
WP:WP4331	Neovascularisation processes	0.004290797135042252	0.004290797135042252	+1	NOTCH1,AKT1,KIT,SMAD2
WP:WP4844	Influence of laminopathies on Wnt signaling	0.004290797135042252	0.004290797135042252	+1	APC,CTNNB1,CEBPA,CCND1
WP:WP5402	10q22q23 copy number variation	0.004682028524658371	0.004682028524658371	+1	CEBPA,ERBB4,SMC1A,SMC3,RAD21
WP:WP4829	mBDNF and proBDNF regulation of GABA neurotransmission	0.004682028524658371	0.004682028524658371	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
WP:WP236	Adipogenesis	0.004904754641157585	0.004904754641157585	+1	GATA3,RB1,CTNNB1,CEBPA,CDKN1A,LIFR,NCOR1
WP:WP4301	Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells	0.004904754641157585	0.004904754641157585	+1	KRAS,NRAS,BRAF
WP:WP2203	Thymic stromal lymphopoietin TSLP signaling pathway	0.005026171865987855	0.005026171865987855	+1	PIK3CA,AKT1,MTOR,PTPN11
WP:WP4564	Neural crest cell migration during development	0.005026171865987855	0.005026171865987855	+1	PIK3CA,AKT1,PIK3CG,EPHB6
WP:WP4258	lncRNA in canonical Wnt signaling and colorectal cancer	0.0051646974753277375	0.0051646974753277375	+1	APC,CTNNB1,CCND1,SOX17,AXIN2,EZH2
WP:WP3915	Angiopoietin like protein 8 regulatory pathway	0.005213932581355342	0.005213932581355342	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG,MTOR
WP:WP2526	PDGF pathway	0.005384139158415136	0.005384139158415136	+1	PIK3R1,MAP3K1,MAP2K4,PTPN11
WP:WP3941	Oxidative damage response	0.005384139158415136	0.005384139158415136	+1	MAP3K1,MAP2K4,CDKN1B,CDKN1A
WP:WP1545	miRNAs involved in DNA damage response	0.0057483549138981245	0.0057483549138981245	+1	TP53,ATM,CDKN1B,CCND1,CDKN1A
WP:WP5316	Primary ovarian insufficiency	0.0057483549138981245	0.0057483549138981245	+1	PTEN,AKT1,ATM,WT1,BRCA1,KIT,BRCA2,TGFBR2
WP:WP3640	Imatinib and chronic myeloid leukemia	0.006139347258106325	0.006139347258106325	+1	CDKN1B,KIT,PDGFRA
WP:WP4206	Hereditary leiomyomatosis and renal cell carcinoma pathway	0.006139347258106325	0.006139347258106325	+1	TP53,KEAP1,NFE2L2
WP:WP5124	Alzheimer 39 s disease	0.006139347258106325	0.006139347258106325	+1	PIK3CA,APC,KRAS,PIK3R1,CTNNB1,NRAS,AKT1,BRAF,MTOR,AXIN2
WP:WP2380	Brain derived neurotrophic factor BDNF signaling pathway	0.006139347258106325	0.006139347258106325	+1	APC,PIK3R1,CTNNB1,MAP3K1,AKT1,MTOR,PTPN11
WP:WP5331	Autophagy in pancreatic ductal adenocarcinoma	0.006139347258106325	0.006139347258106325	+1	TP53,KRAS,NFE2L2
WP:WP4565	Neural crest cell migration in cancer	0.0061416886312456245	0.0061416886312456245	+1	PIK3CA,AKT1,PIK3CG,EPHB6
WP:WP75	Toll like receptor signaling pathway	0.006494228480248125	0.006494228480248125	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PIK3CG,TLR4
WP:WP364	IL6 signaling pathway	0.00658120178443634	0.00658120178443634	+1	PIK3R1,MAP2K4,AKT1,PTPN11
WP:WP2034	Leptin signaling pathway	0.00658120178443634	0.00658120178443634	+1	PTEN,PIK3R1,AKT1,MTOR,PTPN11
WP:WP2059	Alzheimer 39 s disease and miRNA effects	0.0067091192789472415	0.0067091192789472415	+1	PIK3CA,APC,KRAS,PIK3R1,CTNNB1,NRAS,AKT1,BRAF,MTOR,AXIN2
WP:WP3672	lncRNA mediated mechanisms of therapeutic resistance	0.006814783590082605	0.006814783590082605	+1	TP53,CDKN1A
WP:WP4300	Extracellular vesicles in the crosstalk of cardiac cells	0.006814783590082605	0.006814783590082605	+1	PTEN,EGFR,TLR4
WP:WP2882	Nuclear receptors meta pathway	0.007224627819917808	0.007224627819917808	+1	NAV3,EGFR,KEAP1,NFE2L2,EPHA3,CDKN1B,HGF,EP300,CCND1,TGFBR2,SMC1A
WP:WP2873	Aryl hydrocarbon receptor pathway	0.007512586854786022	0.007512586854786022	+1	EGFR,NFE2L2,CDKN1B,EP300
WP:WP5347	IL 26 signaling pathways	0.007512586854786022	0.007512586854786022	+1	PIK3CA,EPHA3,AKT1,SMAD2
WP:WP4141	PI3K AKT mTOR vitamin D3 signaling	0.007613213590642371	0.007613213590642371	+1	PIK3CA,AKT1,MTOR
WP:WP4535	Envelope proteins and their potential roles in EDMD physiopathology	0.008004558287853299	0.008004558287853299	+1	KRAS,NRAS,SMAD4,SMAD2
WP:WP2038	Microtubule cytoskeleton regulation	0.008004558287853299	0.008004558287853299	+1	PIK3CA,PTEN,APC,AKT1
WP:WP4830	GDNF RET signaling axis	0.008378097191385858	0.008378097191385858	+1	GATA3,CTNNB1,SOX17
WP:WP5044	Kynurenine pathway and links to cell senescence	0.008378097191385858	0.008378097191385858	+1	TP53,TLR4,CDKN1A
WP:WP712	Estrogen signaling pathway	0.008378097191385858	0.008378097191385858	+1	PIK3CA,AKT1,BRAF
WP:WP4357	NRF2 ARE regulation	0.008378097191385858	0.008378097191385858	+1	PIK3CA,KEAP1,NFE2L2
WP:WP4904	LDLRAD4 and what we know about it	0.008824756377857622	0.008824756377857622	+1	TGFBR2,SMAD2
WP:WP3953	mRNA protein and metabolite inducation pathway by cyclosporin A	0.008824756377857622	0.008824756377857622	+1	KEAP1,NFE2L2
WP:WP4312	Rett syndrome causing genes	0.008990978370567703	0.008990978370567703	+1	BRAF,SMC1A,TBL1XR1,NCOR1
WP:WP5074	Kallmann syndrome	0.00927451433715499	0.00927451433715499	+1	PIK3CA,AKT1,PTPN11
WP:WP3668	Hypothesized pathways in pathogenesis of cardiovascular disease	0.010381910767914473	0.010381910767914473	+1	SMAD4,TGFBR2,SMAD2
WP:WP3300	Dual hijack model of Vif in HIV infection	0.011348530772154433	0.011348530772154433	+1	RUNX1,CBFB
WP:WP5119	NIPBL role in DNA damage Cornelia de Lange syndrome	0.011348530772154433	0.011348530772154433	+1	ATM,ATR
WP:WP5385	Growth factors and hormones in Beta cell proliferation	0.011436325995441263	0.011436325995441263	+1	KRAS,AKT1,BRAF
WP:WP4747	Netrin UNC5B signaling pathway	0.01162981759597279	0.01162981759597279	+1	TP53,PIK3CA,AKT1,PTPN11
WP:WP4767	FGFR3 signaling in chondrocyte proliferation and terminal differentiation	0.012607695296399823	0.012607695296399823	+1	SOX9,FGFR3,CDKN1A
WP:WP585	Interferon type I signaling pathways	0.013174369391703895	0.013174369391703895	+1	PIK3R1,MAP3K1,MTOR,PTPN11
WP:WP5200	Dravet syndrome	0.013622697576714894	0.013622697576714894	+1	PIK3CA,AKT1,MTOR
WP:WP5036	Angiotensin II receptor type 1 pathway	0.013622697576714894	0.013622697576714894	+1	SMAD4,TGFBR2,PTPN11
WP:WP2643	Nanoparticle mediated activation of receptor signaling	0.013622697576714894	0.013622697576714894	+1	KRAS,EGFR,NRAS
WP:WP5121	Sphingolipid metabolism in senescence	0.013622697576714894	0.013622697576714894	+1	RB1,MTOR,CDKN1A
WP:WP4336	ncRNAs involved in Wnt signaling in hepatocellular carcinoma	0.013980638900406458	0.013980638900406458	+1	APC,CTNNB1,CCND1,SOX17,EZH2
WP:WP3929	Chemokine signaling pathway	0.013980638900406458	0.013980638900406458	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,BRAF,PIK3CG
WP:WP5094	Orexin receptor pathway	0.013980638900406458	0.013980638900406458	+1	VHL,PIK3R1,NFE2L2,MTOR,PTPN11
WP:WP4754	IL 18 signaling pathway	0.014385135233891372	0.014385135233891372	+1	TP53,PTEN,PIK3R1,CTNNB1
WP:WP231	TNF alpha signaling pathway	0.014447376104062177	0.014447376104062177	+1	KRAS,MAP3K1,NRAS,MAP2K4,AKT1
WP:WP4217	Ebola virus infection in host	0.015485498982912804	0.015485498982912804	+1	PIK3CA,EGFR,PIK3R1,AKT1,TLR4,EP300
WP:WP5102	Familial partial lipodystrophy	0.01598228571235962	0.01598228571235962	+1	PIK3CA,GATA3,CEBPA
WP:WP5050	TCA cycle in senescence	0.016330441314577927	0.016330441314577927	+1	TP53,BRAF
WP:WP23	B cell receptor signaling pathway	0.016330441314577927	0.016330441314577927	+1	PIK3R1,AKT1,BRAF,PIK3CG,PTPN11
WP:WP2815	Mammary gland development pathway Involution Stage 4 of 4 	0.016330441314577927	0.016330441314577927	+1	TP53,CDH1
WP:WP4746	Thyroid hormones production and peripheral downstream signaling effects	0.016845561509090626	0.016845561509090626	+1	TP53,PIK3CA,NOTCH1,CTNNB1,MTOR
WP:WP2363	Gastric cancer network 2	0.01709786750524263	0.01709786750524263	+1	TP53,EGFR,CTNNB1
WP:WP4149	White fat cell differentiation	0.018597271260245813	0.018597271260245813	+1	GATA3,CEBPA,MECOM
WP:WP4147	PTF1A related regulatory pathway	0.019310944411429495	0.019310944411429495	+1	NOTCH1,CTNNB1
WP:WP5049	Glycolysis in senescence	0.019310944411429495	0.019310944411429495	+1	TP53,RB1
WP:WP4630	Measles virus infection	0.019636951948522188	0.019636951948522188	+1	TP53,PIK3CA,PIK3R1,CDKN1B,TLR4,CCND1
WP:WP4481	Resistin as a regulator of inflammation	0.019876091649958228	0.019876091649958228	+1	PIK3CA,AKT1,PIK3CG
WP:WP2290	RalA downstream regulated genes	0.022539841993129833	0.022539841993129833	+1	KRAS,NRAS
WP:WP2369	Histone modifications	0.022539841993129833	0.022539841993129833	+1	SETBP1,SETD2,NSD1,EZH2
WP:WP4211	Transcriptional cascade regulating adipogenesis	0.025799559396828844	0.025799559396828844	+1	GATA3,CEBPA
WP:WP4919	Neuroinflammation	0.025799559396828844	0.025799559396828844	+1	MTOR,TLR4
WP:WP4673	Male infertility	0.025799559396828844	0.025799559396828844	+1	NFE2L2,AR,ATM,EP300,BRCA2,ERCC2
WP:WP186	Homologous recombination	0.025799559396828844	0.025799559396828844	+1	ATM,BRCA2
WP:WP2249	Metastatic brain tumor	0.025799559396828844	0.025799559396828844	+1	TP53,PIK3R1
WP:WP49	IL 2 signaling pathway	0.026128756075111736	0.026128756075111736	+1	PIK3R1,AKT1,PTPN11
WP:WP722	Serotonin HTR1 group and FOS pathway	0.026128756075111736	0.026128756075111736	+1	PIK3CA,MAP3K1,BRAF
WP:WP5130	Th17 cell differentiation pathway	0.026615558723428613	0.026615558723428613	+1	GATA3,RUNX1,MTOR,SMAD2
WP:WP3998	Prader Willi and Angelman syndrome	0.028444805887276225	0.028444805887276225	+1	TP53,CDKN2A,RB1,CCND1,CDKN2C
WP:WP5420	ADHD and autism ASD linked metabolic pathways and SNP	0.028906390099159508	0.028906390099159508	+1	PIK3CA,PTEN,EGFR,PIK3R1,CTNNB1,STK11,AKT1,MTOR,KIT,PDGFRA
WP:WP4814	Somatic sex determination	0.028906390099159508	0.028906390099159508	+1	SOX9,WT1
WP:WP3937	Microglia pathogen phagocytosis pathway	0.031430648820772254	0.031430648820772254	+1	PIK3CA,PIK3R1,PIK3CG
WP:WP3594	Circadian rhythm genes	0.03284287888727788	0.03284287888727788	+1	TP53,PTEN,EP300,SIN3A,EGR3,NCOR1,EZH2
WP:WP4538	Regulatory circuits of the STAT3 signaling pathway	0.03416160132378597	0.03416160132378597	+1	EGFR,MTOR,PDGFRA,LIFR
WP:WP5198	Inflammatory bowel disease signaling	0.035209331212061476	0.035209331212061476	+1	GATA3,TLR4,SMAD2
WP:WP314	Fas ligand pathway and stress induction of heat shock proteins	0.035209331212061476	0.035209331212061476	+1	RB1,MAP3K1,MAP2K4
WP:WP5381	Smith Magenis and Potocki Lupski syndrome copy number variation	0.0358646006369912	0.0358646006369912	+1	TP53,PTEN,MTOR,TLR4,FOXA1,FOXA2
WP:WP4970	Galanin receptor pathway	0.0358646006369912	0.0358646006369912	+1	CDKN1B,CDKN1A
WP:WP4928	MAPK pathway in congenital thyroid cancer	0.0358646006369912	0.0358646006369912	+1	KRAS,BRAF
WP:WP2435	Quercetin and Nf kB AP 1 induced apoptosis	0.0358646006369912	0.0358646006369912	+1	KEAP1,NFE2L2
WP:WP5412	8q11 23 RB1CC1 copy number variation	0.0358646006369912	0.0358646006369912	+1	TP53,RB1
WP:WP4136	Fibrin complement receptor 3 signaling pathway	0.036533582470631196	0.036533582470631196	+1	PIK3CA,AKT1,TLR4
WP:WP4823	Genes controlling nephrogenesis	0.03851009223626665	0.03851009223626665	+1	CTNNB1,WT1,FGFR2
WP:WP2332	Interleukin 11 signaling pathway	0.03851009223626665	0.03851009223626665	+1	PIK3R1,AKT1,PTPN11
WP:WP4946	DNA repair pathways full network	0.038828694067607764	0.038828694067607764	+1	ATM,BRCA1,BRCA2,ATR,ERCC2
WP:WP3664	Regulation of Wnt B catenin signaling by small molecule compounds	0.039126032340090974	0.039126032340090974	+1	APC,CTNNB1
WP:WP3413	NOTCH1 regulation of endothelial cell calcification	0.039126032340090974	0.039126032340090974	+1	NOTCH1,FGFR3
WP:WP3935	Leptin insulin signaling overlap	0.039126032340090974	0.039126032340090974	+1	AKT1,PIK3CG
WP:WP5205	Clock controlled autophagy in bone metabolism	0.039668584131371844	0.039668584131371844	+1	NOTCH1,AKT1,MTOR,SMAD4
WP:WP5411	Phosphatidyl inositol phosphate pathway	0.04224262012320974	0.04224262012320974	+1	PIK3CA,PTEN,PIK3CG
WP:WP4533	Transcription co factors SKI and SKIL protein partners	0.042928043144265425	0.042928043144265425	+1	NF1,SIN3A
WP:WP5342	Pathophysiological roles of DUX4 in FSHD1	0.042928043144265425	0.042928043144265425	+1	EP300,CDKN1A
WP:WP4657	22q11 2 copy number variation syndrome	0.04536569015908485	0.04536569015908485	+1	TP53,EGFR,FGFR2,FOXA2,NCOR1
WP:WP286	IL 3 signaling pathway	0.04627864909403817	0.04627864909403817	+1	PIK3R1,AKT1,PTPN11
WP:WP2848	Pluripotent stem cell differentiation pathway	0.04627864909403817	0.04627864909403817	+1	NOTCH1,HGF,KIT
WP:WP4298	Acute viral myocarditis	0.04691951126149358	0.04691951126149358	+1	PIK3R1,AKT1,TLR4,CCND1
WP:WP3888	VEGFA VEGFR2 signaling	0.04691951126149358	0.04691951126149358	+1	PIK3CA,PIK3R1,CTNNB1,MAP2K4,AKT1,MTOR,IDH2,CCND1,PTPN11,EGR3,RPL5
WP:WP4971	Phosphoinositides metabolism	0.0478672002556741	0.0478672002556741	+1	PIK3CA,PTEN,PIK3CG
WP:WP732	Serotonin receptor 2 and ELK SRF GATA4 signaling	0.049953678291107355	0.049953678291107355	+1	KRAS,NRAS
WP:WP205	IL 7 signaling pathway	0.049953678291107355	0.049953678291107355	+1	PIK3R1,AKT1
WP:WP2018	RANKL RANK signaling pathway	0.049953678291107355	0.049953678291107355	+1	PIK3R1,AKT1,MTOR
WP:WP5149	Lipid metabolism in senescent cells	0.049953678291107355	0.049953678291107355	+1	TP53,CDKN1A