GO.ID	Description	p.Val	FDR	Phenotype	Genes
GLIOBLASTOMA SIGNALING PATHWAYS%WIKIPATHWAYS_20240510%WP2261%HOMO SAPIENS	Glioblastoma signaling pathways	2.2752796831618347e-19	2.2752796831618347e-19	+1	PTEN,EGFR,NF1,CDKN2A,RB1,MAP2K4,BRAF,ATM,CDKN1B,BRCA1,PDGFRA,EP300,FGFR2,CCND1,BRCA2,CDKN1A,CDKN2C
HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20240510%WP4674%HOMO SAPIENS	Head and neck squamous cell carcinoma	1.759062715095528e-18	1.759062715095528e-18	+1	PTEN,EGFR,CDKN2A,RB1,NOTCH1,CTNNB1,KEAP1,NFE2L2,STK11,AJUBA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A
PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20240510%WP3651%HOMO SAPIENS	Pathways affected in adenoid cystic carcinoma	1.6398625895458e-14	1.6398625895458e-14	+1	PTEN,ARID1A,NOTCH1,FBXW7,CEBPA,ATM,ARID5B,BRCA1,CHEK2,SETD2,EP300,SMC1A,NCOR1
CELL CYCLE%WIKIPATHWAYS_20240510%WP179%HOMO SAPIENS	Cell cycle	5.030373578108154e-14	5.030373578108154e-14	+1	CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,SMAD4,CDKN1A,ATR,SMC1A,SMC3,SMAD2,RAD21,CDKN2C
REGULATION OF CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:1902806	regulation of cell cycle G1/S phase transition	1.65357488535612e-13	1.65357488535612e-13	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,FBXW7,ATM,CDKN1B,CHEK2,CCND1,CDKN1A,TAF1,CDKN2C,EZH2
MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20240510%WP2857%HOMO SAPIENS	Mesodermal commitment pathway	3.376485148201658e-11	3.376485148201658e-11	+1	GATA3,NFE2L2,TBX3,ARID5B,FOXA1,SETD2,CCND1,SMAD4,FOXA2,SOX17,PHF6,ACVR2A,SMAD2,AXIN2
REGULATION OF PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0071900	regulation of protein serine/threonine kinase activity	3.376485148201658e-11	3.376485148201658e-11	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,FLT3,PIK3CG,CDKN1B,TLR4,LRRK2,CCND1,CDKN1A,CDK12,MAPK8IP1,CDKN2C,EZH2
P53 PATHWAY%PANTHER PATHWAY%P00059	p53 pathway	6.020344520699387e-11	6.020344520699387e-11	+1	TP53,PIK3CA,PTEN,CDKN2A,ATM,CHEK2,EP300,CDKN1A,ATR,SIN3A
REGULATION OF G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:2000045	regulation of G1/S transition of mitotic cell cycle	7.669875049666816e-11	7.669875049666816e-11	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A,CDKN2C
BREAST CANCER PATHWAY%WIKIPATHWAYS_20240510%WP4262%HOMO SAPIENS	Breast cancer pathway	7.669875049666816e-11	7.669875049666816e-11	+1	PTEN,EGFR,RB1,NOTCH1,CTNNB1,BRAF,ATM,BRCA1,KIT,CCND1,BRCA2,CDKN1A,ATR,AXIN2
BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY	BIOCARTA_G1_PATHWAY	1.5169845707666422e-10	1.5169845707666422e-10	+1	CDKN2A,RB1,ATM,CDKN1B,CCND1,SMAD4,CDKN1A,ATR
REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0010717	regulation of epithelial to mesenchymal transition	2.337089108676405e-10	2.337089108676405e-10	+1	PTEN,GATA3,NOTCH1,CTNNB1,EPHA3,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20240510%WP2263%HOMO SAPIENS	Androgen receptor network in prostate cancer	2.337089108676405e-10	2.337089108676405e-10	+1	PTEN,ARID1A,RB1,ATM,HGF,BRCA1,FOXA1,CHEK2,CCND1,ATR,PTPN11,SMAD2
NEGATIVE REGULATION OF GROWTH%GOBP%GO:0045926	negative regulation of growth	2.789948548661015e-10	2.789948548661015e-10	+1	TP53,PTEN,CDKN2A,RB1,STK11,CDKN1B,WT1,BRCA1,SMAD4,FGFR3,SOX17,CDKN1A,ACVR1B,CDKN2C
INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20240510%WP1971%HOMO SAPIENS	Integrated cancer pathway	6.211675407047264e-10	6.211675407047264e-10	+1	PTEN,RB1,ATM,CDKN1B,BRCA1,CHEK2,CDKN1A,ATR,SMAD2
P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398	p53 pathway feedback loops 2	7.47487515161446e-10	7.47487515161446e-10	+1	TP53,PIK3CA,PTEN,RB1,CTNNB1,PIK3CG,ATM,CDKN1A,ATR
PROTEIN AUTOPHOSPHORYLATION%GOBP%GO:0046777	protein autophosphorylation	2.2412579833146482e-9	2.2412579833146482e-9	+1	EGFR,FLT3,STK11,ATM,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,TAF1,ATR,CDK12,ACVR1B
SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 81%3108232	SUMO E3 ligases SUMOylate target proteins	4.00883741897946e-9	4.00883741897946e-9	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
NEGATIVE REGULATION OF CELL GROWTH%GOBP%GO:0030308	negative regulation of cell growth	4.00883741897946e-9	4.00883741897946e-9	+1	TP53,CDKN2A,RB1,STK11,CDKN1B,WT1,BRCA1,SMAD4,SOX17,CDKN1A,ACVR1B,CDKN2C
ANDROGEN RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP138%HOMO SAPIENS	Androgen receptor signaling pathway	4.00883741897946e-9	4.00883741897946e-9	+1	PTEN,EGFR,RB1,CTNNB1,BRCA1,EP300,CCND1,SMAD4,SIN3A,NCOR1
PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20240510%WP4263%HOMO SAPIENS	Pancreatic adenocarcinoma pathway	4.00883741897946e-9	4.00883741897946e-9	+1	EGFR,CDKN2A,RB1,BRAF,CCND1,SMAD4,BRCA2,TGFBR2,CDKN1A,SMAD2
PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY	PID_CMYB_PATHWAY	4.00883741897946e-9	4.00883741897946e-9	+1	CDKN2A,GATA3,CEBPA,CDKN1B,KIT,EP300,CCND1,CDKN1A,SIN3A,NCOR1
ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR	AndrogenReceptor	5.3019369867542095e-9	5.3019369867542095e-9	+1	PTEN,EGFR,RB1,CTNNB1,CEBPA,BRCA1,FOXA1,EP300,CCND1,SMAD4,SIN3A
SUMOYLATION%REACTOME DATABASE ID RELEASE 81%2990846	SUMOylation	5.912737227383288e-9	5.912737227383288e-9	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
CELLULAR RESPONSE TO ABIOTIC STIMULUS%GOBP%GO:0071214	cellular response to abiotic stimulus	6.00475991787437e-9	6.00475991787437e-9	+1	TP53,PIK3CA,PTEN,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,BRCA1,EP300,BRCA2,CDKN1A,TAF1,ATR
CELLULAR RESPONSE TO ENVIRONMENTAL STIMULUS%GOBP%GO:0104004	cellular response to environmental stimulus	6.00475991787437e-9	6.00475991787437e-9	+1	TP53,PIK3CA,PTEN,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,BRCA1,EP300,BRCA2,CDKN1A,TAF1,ATR
ENDOMETRIAL CANCER%WIKIPATHWAYS_20240510%WP4155%HOMO SAPIENS	Endometrial cancer	6.706487275303663e-9	6.706487275303663e-9	+1	PTEN,EGFR,CTNNB1,BRAF,FGFR2,CCND1,FGFR3,CDKN1A,AXIN2
TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR	TGF_beta_Receptor	7.110342156562175e-9	7.110342156562175e-9	+1	RB1,CTNNB1,CTCF,STK11,SOX9,BRCA1,EP300,CCND1,SMAD4,TGFBR2,CDKN1A,SMAD2
TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20240510%WP5300%HOMO SAPIENS	TROP2 regulatory signaling	1.2231770298566509e-8	1.2231770298566509e-8	+1	PTEN,EGFR,CDKN2A,RB1,NOTCH1,CTNNB1,CDKN1B,CCND1
NEGATIVE REGULATION OF G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	1.2231770298566509e-8	1.2231770298566509e-8	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING	Regulation of nuclear SMAD2 3 signaling	1.4131222199002204e-8	1.4131222199002204e-8	+1	GATA3,RUNX1,AR,EP300,SMAD4,CDKN1A,CBFB,SIN3A,NCOR1,SMAD2
MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20240510%WP3584%HOMO SAPIENS	MECP2 and associated Rett syndrome	1.5548438989415187e-8	1.5548438989415187e-8	+1	PTEN,NF1,CTCF,TET2,TAF1,SIN3A,SMC3,NCOR1,EZH2
C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK	C-MYB transcription factor network	1.6954259175182475e-8	1.6954259175182475e-8	+1	CDKN2A,GATA3,CEBPA,CDKN1B,KIT,EP300,CCND1,CDKN1A,SIN3A,NCOR1
ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.6	ESR-mediated signaling	1.7888896409622558e-8	1.7888896409622558e-8	+1	PIK3CA,EGFR,GATA3,RUNX1,STAG2,CDKN1B,FOXA1,EP300,CCND1,CBFB,SMC1A,SMC3,RAD21
DNA DAMAGE RESPONSE%WIKIPATHWAYS_20240510%WP707%HOMO SAPIENS	DNA damage response	2.1965180337316286e-8	2.1965180337316286e-8	+1	RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR,SMC1A
NEGATIVE REGULATION OF CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:1902807	negative regulation of cell cycle G1/S phase transition	2.1965180337316286e-8	2.1965180337316286e-8	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION	Validated targets of C-MYC transcriptional repression	2.3531259506679813e-8	2.3531259506679813e-8	+1	DNMT3A,CEBPA,CDKN1B,BRCA1,EP300,CCND1,SMAD4,CDKN1A,SMAD2
PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY	PID_E2F_PATHWAY	2.3531259506679813e-8	2.3531259506679813e-8	+1	CDKN2A,RB1,CEBPA,ATM,CDKN1B,BRCA1,EP300,CDKN1A,CDKN2C
MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20240510%WP1530%HOMO SAPIENS	miRNA regulation of DNA damage response	2.3531259506679813e-8	2.3531259506679813e-8	+1	RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR,SMC1A
PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20240510%WP3611%HOMO SAPIENS	Photodynamic therapy induced AP 1 survival signaling	2.650115603213477e-8	2.650115603213477e-8	+1	EGFR,CDKN2A,RB1,NFE2L2,MAP2K4,PDGFRA,CCND1,CDKN1A
FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2	Formation of definitive endoderm	2.8902101813898562e-8	2.8902101813898562e-8	+1	CTNNB1,CDH1,SMAD4,FOXA2,SOX17,SMAD2
PI3K AKT SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 81%2219528	PI3K AKT Signaling in Cancer	2.9891230283234305e-8	2.9891230283234305e-8	+1	PIK3CA,PTEN,EGFR,FLT3,CDKN1B,HGF,KIT,PDGFRA,CDKN1A,PTPN11
CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.4	Chromatin organization	2.9989004803394133e-8	2.9989004803394133e-8	+1	ARID1A,PBRM1,DNMT3A,KDM6A,KDM5C,ARID5B,SETD2,EP300,CCND1,NSD1,TBL1XR1,MECOM,NCOR1,EZH2
CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 81%3247509	Chromatin modifying enzymes	2.9989004803394133e-8	2.9989004803394133e-8	+1	ARID1A,PBRM1,DNMT3A,KDM6A,KDM5C,ARID5B,SETD2,EP300,CCND1,NSD1,TBL1XR1,MECOM,NCOR1,EZH2
HEART VALVE DEVELOPMENT%GOBP%GO:0003170	heart valve development	3.1396854937573576e-8	3.1396854937573576e-8	+1	APC,GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2,SMAD2,AXIN2
DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20240510%WP3959%HOMO SAPIENS	DNA IR double strand breaks and cellular response via ATM	3.9953877224125314e-8	3.9953877224125314e-8	+1	CDKN2A,ATM,BRCA1,CHEK2,BRCA2,ATR,SMC1A,SMC3
CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20240510%WP4018%HOMO SAPIENS	Clear cell renal cell carcinoma pathways	3.9953877224125314e-8	3.9953877224125314e-8	+1	PTEN,VHL,PBRM1,EGFR,BAP1,KDM5C,SETD2,PDGFRA,EP300
TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 81%8878159	Transcriptional regulation by RUNX3	4.026988419933299e-8	4.026988419933299e-8	+1	TP53,CDKN2A,NOTCH1,CTNNB1,RUNX1,EP300,CCND1,SMAD4,CDKN1A,CBFB
CELLULAR SENESCENCE%GOBP%GO:0090398	cellular senescence	4.594373393407045e-8	4.594373393407045e-8	+1	TP53,CDKN2A,NPM1,TBX3,MAP2K4,ATM,CDKN1B,CDKN1A
PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY	PID_SMAD2_3NUCLEAR_PATHWAY	4.861848411222051e-8	4.861848411222051e-8	+1	GATA3,RUNX1,EP300,SMAD4,CDKN1A,CBFB,SIN3A,NCOR1,SMAD2
HALLMARK_E2F_TARGETS%MSIGDBHALLMARK%HALLMARK_E2F_TARGETS	HALLMARK_E2F_TARGETS	5.584641020871895e-8	5.584641020871895e-8	+1	CDKN2A,CTCF,CDKN1B,BRCA1,CHEK2,BRCA2,CDKN1A,SMC1A,SMC3,RAD21,CDKN2C,EZH2
EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20240510%WP4806%HOMO SAPIENS	EGFR tyrosine kinase inhibitor resistance	6.869844214349659e-8	6.869844214349659e-8	+1	PTEN,EGFR,NF1,BRAF,HGF,PDGFRA,FGFR2,CCND1,FGFR3
E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK	E2F transcription factor network	7.633408672298237e-8	7.633408672298237e-8	+1	CDKN2A,RB1,CEBPA,ATM,CDKN1B,BRCA1,EP300,CDKN1A,CDKN2C
PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY	PID_MYC_REPRESS_PATHWAY	9.719800499422436e-8	9.719800499422436e-8	+1	CEBPA,CDKN1B,BRCA1,EP300,CCND1,SMAD4,CDKN1A,SMAD2
BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY	BIOCARTA_CTCF_PATHWAY	1.1442176497784144e-7	1.1442176497784144e-7	+1	PTEN,CDKN2A,CTCF,CDKN1B,SMAD4,TGFBR2
BLADDER CANCER%WIKIPATHWAYS_20240510%WP2828%HOMO SAPIENS	Bladder cancer	1.2378515205697765e-7	1.2378515205697765e-7	+1	EGFR,CDKN2A,RB1,BRAF,CCND1,FGFR3,CDKN1A
NEGATIVE REGULATION OF MITOTIC CELL CYCLE PHASE TRANSITION%GOBP%GO:1901991	negative regulation of mitotic cell cycle phase transition	1.3026552953805091e-7	1.3026552953805091e-7	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR
REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION	Regulation of nuclear beta catenin signaling and target gene transcription	1.416970948301009e-7	1.416970948301009e-7	+1	APC,CDKN2A,CTNNB1,CDH1,AR,EP300,CCND1,TBL1XR1,AXIN2
MELANOMA%WIKIPATHWAYS_20240510%WP4685%HOMO SAPIENS	Melanoma	1.416970948301009e-7	1.416970948301009e-7	+1	PTEN,NF1,CDKN2A,RB1,BRAF,KIT,CCND1,CDKN1A
NEGATIVE REGULATION OF MITOTIC CELL CYCLE%GOBP%GO:0045930	negative regulation of mitotic cell cycle	1.444187742851945e-7	1.444187742851945e-7	+1	TP53,PTEN,APC,RB1,CTNNB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR
HEART VALVE MORPHOGENESIS%GOBP%GO:0003179	heart valve morphogenesis	1.564950868347726e-7	1.564950868347726e-7	+1	GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2,SMAD2,AXIN2
REGULATION OF CYCLIN-DEPENDENT PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	1.564950868347726e-7	1.564950868347726e-7	+1	PTEN,APC,EGFR,CDKN2A,CDKN1B,CCND1,CDKN1A,CDKN2C
BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY	BIOCARTA_G2_PATHWAY	1.9465353119986146e-7	1.9465353119986146e-7	+1	ATM,BRCA1,CHEK2,EP300,CDKN1A,ATR
BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY	BIOCARTA_CELLCYCLE_PATHWAY	1.9465353119986146e-7	1.9465353119986146e-7	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,CDKN2C
ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 81%9018519	Estrogen-dependent gene expression	2.1504098806154796e-7	2.1504098806154796e-7	+1	GATA3,RUNX1,STAG2,FOXA1,EP300,CCND1,CBFB,SMC1A,SMC3,RAD21
PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY	PID_RB_1PATHWAY	2.1928062104510368e-7	2.1928062104510368e-7	+1	CDKN2A,RB1,CEBPA,CDKN1B,EP300,CCND1,CDKN1A,TAF1
REGULATION OF CYCLIN-DEPENDENT PROTEIN KINASE ACTIVITY%GOBP%GO:1904029	regulation of cyclin-dependent protein kinase activity	2.1928062104510368e-7	2.1928062104510368e-7	+1	PTEN,APC,EGFR,CDKN2A,CDKN1B,CCND1,CDKN1A,CDKN2C
NEGATIVE REGULATION OF CELL CYCLE PROCESS%GOBP%GO:0010948	negative regulation of cell cycle process	2.1928062104510368e-7	2.1928062104510368e-7	+1	TP53,PTEN,APC,RB1,NPM1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,CCND1,CDKN1A,ATR
HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20240510%WP4541%HOMO SAPIENS	Hippo Merlin signaling dysregulation	2.29097553342818e-7	2.29097553342818e-7	+1	EGFR,CTNNB1,FLT3,AJUBA,KIT,PDGFRA,FGFR2,CCND1,FGFR3
SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20240510%WP5118%HOMO SAPIENS	SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome	2.630170099479199e-7	2.630170099479199e-7	+1	ATM,BRCA1,SMC1A,SMC3,RAD21
AORTIC VALVE MORPHOGENESIS%GOBP%GO:0003180	aortic valve morphogenesis	2.6821808602527016e-7	2.6821808602527016e-7	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2,SMAD2,AXIN2
ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20240510%WP2586%HOMO SAPIENS	Aryl hydrocarbon receptor pathway	2.6821808602527016e-7	2.6821808602527016e-7	+1	EGFR,NF1,RB1,NFE2L2,CDKN1B,EP300,CDKN1A
CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20240510%WP4216%HOMO SAPIENS	Chromosomal and microsatellite instability in colorectal cancer	3.06608794362828e-7	3.06608794362828e-7	+1	CTNNB1,BRAF,CCND1,SMAD4,TGFBR2,CDKN1A,SMAD2,AXIN2
REPRODUCTION%REACTOME%R-HSA-1474165.6	Reproduction	3.0925660836929295e-7	3.0925660836929295e-7	+1	STAG2,ATM,TET2,BRCA1,BRCA2,SOX17,ATR,SMC1A,SMC3,RAD21
EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20240510%WP2870%HOMO SAPIENS	Extracellular vesicle mediated signaling in recipient cells	4.057081361773871e-7	4.057081361773871e-7	+1	EGFR,CTNNB1,HGF,SMAD4,TGFBR2,SMAD2
REPLICATIVE SENESCENCE%GOBP%GO:0090399	replicative senescence	4.1320201498360475e-7	4.1320201498360475e-7	+1	TP53,CDKN2A,ATM,CHEK2,ATR
REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN	Regulation of retinoblastoma protein	4.271927639506703e-7	4.271927639506703e-7	+1	CDKN2A,RB1,CEBPA,CDKN1B,EP300,CCND1,CDKN1A,TAF1
HEART MORPHOGENESIS%GOBP%GO:0003007	heart morphogenesis	4.3204886195749335e-7	4.3204886195749335e-7	+1	APC,GATA3,NOTCH1,CTNNB1,TBX3,SOX9,FGFR2,SMAD4,TGFBR2,SOX17,SMAD2
REGULATION OF MIRNA TRANSCRIPTION%GOBP%GO:1902893	regulation of miRNA transcription	4.7134237420772294e-7	4.7134237420772294e-7	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,FOXA1,NCOR1
MESENCHYME DEVELOPMENT%GOBP%GO:0060485	mesenchyme development	4.779200114400655e-7	4.779200114400655e-7	+1	APC,NOTCH1,CTNNB1,TBX3,SOX9,WT1,HGF,FGFR2,SMAD4,TGFBR2,SMAD2
AORTIC VALVE DEVELOPMENT%GOBP%GO:0003176	aortic valve development	5.787873506994713e-7	5.787873506994713e-7	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2,SMAD2,AXIN2
NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 81%199418	Negative regulation of the PI3K AKT network	6.61774668745851e-7	6.61774668745851e-7	+1	PIK3CA,PTEN,EGFR,FLT3,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20240510%WP3931%HOMO SAPIENS	Embryonic stem cell pluripotency pathways	6.61774668745851e-7	6.61774668745851e-7	+1	PTEN,EGFR,CTNNB1,BRAF,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY	PID_NOTCH_PATHWAY	6.61774668745851e-7	6.61774668745851e-7	+1	GATA3,NOTCH1,FBXW7,EP300,CCND1,CDKN1A,NCOR1
AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK	AP-1 transcription factor network	6.969532591709208e-7	6.969532591709208e-7	+1	TP53,PTEN,CDKN2A,CTNNB1,CDKN1B,EP300,CCND1,CBFB
SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0072331	signal transduction by p53 class mediator	6.969532591709208e-7	6.969532591709208e-7	+1	TP53,STK11,ATM,CDKN1B,ATRX,CHEK2,EP300,CDKN1A
CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME%R-HSA-69231.11	Cyclin D associated events in G1	7.364407229506435e-7	7.364407229506435e-7	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
G1 PHASE%REACTOME%R-HSA-69236.6	G1 Phase	7.364407229506435e-7	7.364407229506435e-7	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
NEGATIVE REGULATION OF TRANSFERASE ACTIVITY%GOBP%GO:0051348	negative regulation of transferase activity	8.35563411735693e-7	8.35563411735693e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CDKN1B,FOXA2,CDKN1A,EIF4A2,MAPK8IP1
MITOTIC G1/S TRANSITION CHECKPOINT SIGNALING%GOBP%GO:0044819	mitotic G1/S transition checkpoint signaling	9.169130505839657e-7	9.169130505839657e-7	+1	TP53,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
MITOTIC G1 DNA DAMAGE CHECKPOINT SIGNALING%GOBP%GO:0031571	mitotic G1 DNA damage checkpoint signaling	9.169130505839657e-7	9.169130505839657e-7	+1	TP53,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
REPRODUCTIVE SYSTEM DEVELOPMENT%GOBP%GO:0061458	reproductive system development	9.241982766514038e-7	9.241982766514038e-7	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
REPRODUCTIVE STRUCTURE DEVELOPMENT%GOBP%GO:0048608	reproductive structure development	9.241982766514038e-7	9.241982766514038e-7	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
SEMI-LUNAR VALVE DEVELOPMENT%GOBP%GO:1905314	semi-lunar valve development	9.386040987289265e-7	9.386040987289265e-7	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2,SMAD2,AXIN2
CELLULAR RESPONSE TO RADIATION%GOBP%GO:0071478	cellular response to radiation	9.769221761472587e-7	9.769221761472587e-7	+1	TP53,NPM1,STK11,ATM,BRCA1,EP300,BRCA2,CDKN1A,TAF1,ATR
REGULATION OF MIRNA METABOLIC PROCESS%GOBP%GO:2000628	regulation of miRNA metabolic process	0.0000010870547068146462	0.0000010870547068146462	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,FOXA1,NCOR1
HIPPO SIGNALING REGULATION PATHWAYS%WIKIPATHWAYS_20240510%WP4540%HOMO SAPIENS	Hippo signaling regulation pathways	0.0000011961592116761483	0.0000011961592116761483	+1	EGFR,CTNNB1,FLT3,KIT,PDGFRA,FGFR2,FGFR3,SMAD2
NEGATIVE REGULATION OF PHOSPHORYLATION%GOBP%GO:0042326	negative regulation of phosphorylation	0.0000013192268776640793	0.0000013192268776640793	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CDKN1B,LRRK2,FOXA2,CDKN1A,MAPK8IP1,CDKN2C
POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0010718	positive regulation of epithelial to mesenchymal transition	0.0000013796959950930907	0.0000013796959950930907	+1	NOTCH1,CTNNB1,SMAD4,TGFBR2,SMAD2,AXIN2,EZH2
CELL FATE COMMITMENT%GOBP%GO:0045165	cell fate commitment	0.0000013830118390505789	0.0000013830118390505789	+1	APC,GATA3,TBX3,SOX9,WT1,FGFR2,SMAD4,FOXA2,SOX17,SMAD2
NEGATIVE REGULATION OF KINASE ACTIVITY%GOBP%GO:0033673	negative regulation of kinase activity	0.0000014608667274095722	0.0000014608667274095722	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CDKN1B,FOXA2,CDKN1A,MAPK8IP1
REGULATION OF CHROMOSOME ORGANIZATION%GOBP%GO:0033044	regulation of chromosome organization	0.0000015286763057420517	0.0000015286763057420517	+1	TP53,APC,ARID1A,PBRM1,RB1,CTNNB1,CTCF,ATM,ATRX,ATR,AXIN2,RAD21
POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE/THREONINE KINASE SIGNALING PATHWAY%GOBP%GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.0000018720512649051888	0.0000018720512649051888	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION%GOBP%GO:1901988	negative regulation of cell cycle phase transition	0.000001933634475059852	0.000001933634475059852	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR
PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY	PID_ATF2_PATHWAY	0.0000019591930606658213	0.0000019591930606658213	+1	NF1,RB1,BRCA1,PDGFRA,EP300,CCND1,CBFB
MITOTIC CELL CYCLE CHECKPOINT SIGNALING%GOBP%GO:0007093	mitotic cell cycle checkpoint signaling	0.0000021129177208600646	0.0000021129177208600646	+1	TP53,APC,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR
G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20240510%WP45%HOMO SAPIENS	G1 to S cell cycle control	0.000002171261386030136	0.000002171261386030136	+1	CDKN2A,RB1,ATM,CDKN1B,CCND1,CDKN1A,CDKN2C
ESTABLISHMENT OF MITOTIC SISTER CHROMATID COHESION%GOBP%GO:0034087	establishment of mitotic sister chromatid cohesion	0.000002171261386030136	0.000002171261386030136	+1	STAG2,SMC1A,SMC3,RAD21
REGULATION OF SISTER CHROMATID COHESION%GOBP%GO:0007063	regulation of sister chromatid cohesion	0.000002175035315848639	0.000002175035315848639	+1	CTNNB1,CTCF,ATRX,AXIN2,RAD21
HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20240510%WP3657%HOMO SAPIENS	Hematopoietic stem cell gene regulation by GABP alpha beta complex	0.000002175035315848639	0.000002175035315848639	+1	PTEN,FLT3,ATM,EP300,SMAD4
MEIOSIS%REACTOME DATABASE ID RELEASE 81%1500620	Meiosis	0.000002317916113298273	0.000002317916113298273	+1	STAG2,ATM,BRCA1,BRCA2,ATR,SMC1A,SMC3,RAD21
ENDOCARDIAL CUSHION MORPHOGENESIS%GOBP%GO:0003203	endocardial cushion morphogenesis	0.0000025560661093532214	0.0000025560661093532214	+1	APC,NOTCH1,TBX3,SOX9,TGFBR2,SMAD2
REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE/PROTEIN KINASE B SIGNAL TRANSDUCTION%GOBP%GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	0.0000025560661093532214	0.0000025560661093532214	+1	PIK3CA,PTEN,EGFR,GATA3,FLT3,PIK3CG,HGF,KIT,PDGFRA,FGFR3,PPP2R1A
REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5	Regulation of TP53 Activity	0.0000025578188739169835	0.0000025578188739169835	+1	TP53,CDKN2A,STK11,ATM,BRCA1,CHEK2,EP300,TAF1,PPP2R1A,ATR
NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY	Notch signaling pathway	0.0000029746560281797025	0.0000029746560281797025	+1	GATA3,NOTCH1,FBXW7,EP300,CCND1,CDKN1A,NCOR1
ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20240510%WP2853%HOMO SAPIENS	Endoderm differentiation	0.0000029934143806726683	0.0000029934143806726683	+1	NOTCH1,CTNNB1,FOXA1,SMAD4,FOXA2,SOX17,PHF6,SMAD2,EZH2
POSITIVE REGULATION OF UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	0.0000031584163315426455	0.0000031584163315426455	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,AXIN2
REGULATION OF MAP KINASE ACTIVITY%GOBP%GO:0043405	regulation of MAP kinase activity	0.0000031584163315426455	0.0000031584163315426455	+1	EGFR,NF1,FLT3,PIK3CG,TLR4,LRRK2,CDK12,MAPK8IP1,EZH2
ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK	ATF-2 transcription factor network	0.000003244774333481207	0.000003244774333481207	+1	NF1,RB1,BRCA1,PDGFRA,EP300,CCND1,CBFB
DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20240510%WP710%HOMO SAPIENS	DNA damage response only ATM dependent	0.000003384002029109547	0.000003384002029109547	+1	PTEN,CDKN2A,CTNNB1,ATM,CDKN1B,CCND1,SMAD4,CDKN1A
GASTRULATION%REACTOME DATABASE ID RELEASE 81%9758941	Gastrulation	0.0000035415592423179074	0.0000035415592423179074	+1	NOTCH1,CTNNB1,CDH1,FOXA1,EP300,SMAD4,FOXA2,SOX17,SMAD2
NEGATIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN KINASE ACTIVITY%GOBP%GO:1904030	negative regulation of cyclin-dependent protein kinase activity	0.0000036185387029268355	0.0000036185387029268355	+1	PTEN,APC,CDKN2A,CDKN1B,CDKN1A
DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR RESULTING IN CELL CYCLE ARREST%GOBP%GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	0.0000036185387029268355	0.0000036185387029268355	+1	TP53,ATM,CDKN1B,CHEK2,CDKN1A
GLAND DEVELOPMENT%GOBP%GO:0048732	gland development	0.000003702279604890698	0.000003702279604890698	+1	NF1,ARHGAP35,TBX3,CEBPA,SOX9,WT1,ARID5B,ELF3,FGFR2
DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0030330	DNA damage response, signal transduction by p53 class mediator	0.000003902013886629384	0.000003902013886629384	+1	TP53,ATM,CDKN1B,ATRX,CHEK2,CDKN1A
SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE%GOBP%GO:0042770	signal transduction in response to DNA damage	0.000003902013886629384	0.000003902013886629384	+1	TP53,ATM,CDKN1B,ATRX,BRCA1,CHEK2,CCND1,CDKN1A,ATR
PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 81%6811558	PI5P, PP2A and IER3 Regulate PI3K AKT Signaling	0.000004148687385335054	0.000004148687385335054	+1	PIK3CA,EGFR,FLT3,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY	PID_AP1_PATHWAY	0.000004281609141780309	0.000004281609141780309	+1	PTEN,CDKN2A,CTNNB1,CDKN1B,EP300,CCND1,CBFB
PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY	PID_FOXM1_PATHWAY	0.000004502731327754757	0.000004502731327754757	+1	CDKN2A,RB1,CHEK2,EP300,CCND1,BRCA2
MITOTIC SISTER CHROMATID COHESION%GOBP%GO:0007064	mitotic sister chromatid cohesion	0.00000454199178639584	0.00000454199178639584	+1	RB1,STAG2,SMC1A,SMC3,RAD21
RESPONSE TO UV%GOBP%GO:0009411	response to UV	0.0000045885583007898255	0.0000045885583007898255	+1	TP53,EGFR,NPM1,STK11,EP300,CCND1,CDKN1A,TAF1,ATR
MESENCHYME MORPHOGENESIS%GOBP%GO:0072132	mesenchyme morphogenesis	0.0000051349672127526345	0.0000051349672127526345	+1	APC,NOTCH1,TBX3,SOX9,TGFBR2,SMAD2
EPIGENETIC REGULATION OF GENE EXPRESSION%GOBP%GO:0040029	epigenetic regulation of gene expression	0.0000051349672127526345	0.0000051349672127526345	+1	TP53,ARID1A,RB1,DNMT3A,CTCF,WT1,TET2,ATRX,BRCA1,EP300,EZH2
E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES	E-cadherin signaling in keratinocytes	0.000005669737337719076	0.000005669737337719076	+1	PIK3CA,EGFR,CTNNB1,CDH1,AJUBA
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 81%2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.000005669737337719076	0.000005669737337719076	+1	PIK3CA,EGFR,FLT3,HGF,KIT,PDGFRA,PTPN11
BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY	BIOCARTA_ATRBRCA_PATHWAY	0.000005669737337719076	0.000005669737337719076	+1	ATM,BRCA1,CHEK2,BRCA2,ATR
ENDOCARDIAL CUSHION DEVELOPMENT%GOBP%GO:0003197	endocardial cushion development	0.0000058347581885198995	0.0000058347581885198995	+1	APC,NOTCH1,TBX3,SOX9,TGFBR2,SMAD2
RUNX3 REGULATES P14-ARF%REACTOME%R-HSA-8951936.2	RUNX3 regulates p14-ARF	0.0000060045622621068276	0.0000060045622621068276	+1	RUNX1,EP300,CCND1,CBFB
FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3	FOXO-mediated transcription	0.000006115495886078577	0.000006115495886078577	+1	STK11,CDKN1B,EP300,SMAD4,CDKN1A,SIN3A,SMAD2
FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK	FOXM1 transcription factor network	0.000006533764746053588	0.000006533764746053588	+1	CDKN2A,RB1,CHEK2,EP300,CCND1,BRCA2
DNA DAMAGE CHECKPOINT SIGNALING%GOBP%GO:0000077	DNA damage checkpoint signaling	0.000006533764746053588	0.000006533764746053588	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR
SISTER CHROMATID COHESION%GOBP%GO:0007062	sister chromatid cohesion	0.000006533764746053588	0.000006533764746053588	+1	RB1,FBXW7,STAG2,SMC1A,SMC3,RAD21
PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY	PID_DELTA_NP63_PATHWAY	0.000006533764746053588	0.000006533764746053588	+1	CDKN2A,NOTCH1,FBXW7,RUNX1,ATM,BRCA2
NEGATIVE REGULATION OF PROTEIN KINASE ACTIVITY%GOBP%GO:0006469	negative regulation of protein kinase activity	0.000006547631814094595	0.000006547631814094595	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CDKN1B,CDKN1A,MAPK8IP1
DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS	Direct p53 effectors	0.000006919817301222628	0.000006919817301222628	+1	TP53,PTEN,APC,EGFR,RB1,HGF,FOXA1,EP300,CDKN1A
REGULATION OF DEVELOPMENTAL GROWTH%GOBP%GO:0048638	regulation of developmental growth	0.000007309837967888022	0.000007309837967888022	+1	PTEN,NOTCH1,RUNX1,EPPK1,CDKN1B,WT1,FGFR2,FGFR3,CDKN1A
GASTRIN SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP4659%HOMO SAPIENS	Gastrin signaling pathway	0.000007425088934050282	0.000007425088934050282	+1	EGFR,CDKN2A,CTNNB1,CDKN1B,KIT,CCND1,CDKN1A,PTPN11
REGULATION OF UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:2000058	regulation of ubiquitin-dependent protein catabolic process	0.00000860148824070421	0.00000860148824070421	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,AXIN2
EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0001837	epithelial to mesenchymal transition	0.00000860148824070421	0.00000860148824070421	+1	NOTCH1,CTNNB1,TBX3,SOX9,HGF,SMAD4,TGFBR2
POSITIVE REGULATION OF PROTEIN KINASE ACTIVITY%GOBP%GO:0045860	positive regulation of protein kinase activity	0.000008806961773336484	0.000008806961773336484	+1	EGFR,FBXW7,FLT3,STK11,PIK3CG,TLR4,LRRK2,CCND1,TGFBR2,CDKN1A,EZH2
COHESIN LOADING ONTO CHROMATIN%REACTOME%R-HSA-2470946.2	Cohesin Loading onto Chromatin	0.000009101460313988335	0.000009101460313988335	+1	STAG2,SMC1A,SMC3,RAD21
OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20240510%WP4879%HOMO SAPIENS	Overlap between signal transduction pathways contributing to LMNA laminopathies	0.000009291881300861288	0.000009291881300861288	+1	RB1,NOTCH1,CTNNB1,CEBPA,CDKN1A,SMAD2
NRP1 TRIGGERED SIGNALING PATHWAYS IN PANCREATIC CANCER %WIKIPATHWAYS_20240510%WP5144%HOMO SAPIENS	NRP1 triggered signaling pathways in pancreatic cancer	0.000009291881300861288	0.000009291881300861288	+1	EGFR,CDKN1B,HGF,SMAD4,TGFBR2,SMAD2
RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20240510%WP2446%HOMO SAPIENS	Retinoblastoma gene in cancer	0.000009291881300861288	0.000009291881300861288	+1	RB1,CDKN1B,CCND1,CDKN1A,SIN3A,SMC1A,SMC3
FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK	FOXA1 transcription factor network	0.000009291881300861288	0.000009291881300861288	+1	AR,CDKN1B,BRCA1,FOXA1,EP300,FOXA2
MITOTIC DNA DAMAGE CHECKPOINT SIGNALING%GOBP%GO:0044773	mitotic DNA damage checkpoint signaling	0.000009991511960465461	0.000009991511960465461	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
NEGATIVE REGULATION OF PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0071901	negative regulation of protein serine/threonine kinase activity	0.000010924068668775861	0.000010924068668775861	+1	PTEN,APC,NF1,CDKN2A,RB1,CDKN1B,MAPK8IP1
ANGIOGENESIS%PANTHER PATHWAY%P00005	Angiogenesis	0.000011376933833082817	0.000011376933833082817	+1	PIK3CA,APC,NOTCH1,CTNNB1,MAP2K4,EPHA3,BRAF,PIK3CG,PDGFRA
CELL CYCLE CHECKPOINT SIGNALING%GOBP%GO:0000075	cell cycle checkpoint signaling	0.000011376933833082817	0.000011376933833082817	+1	TP53,APC,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR
POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE/PROTEIN KINASE B SIGNAL TRANSDUCTION%GOBP%GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	0.000011376933833082817	0.000011376933833082817	+1	PIK3CA,EGFR,GATA3,FLT3,PIK3CG,HGF,KIT,PDGFRA,FGFR3
DNA INTEGRITY CHECKPOINT SIGNALING%GOBP%GO:0031570	DNA integrity checkpoint signaling	0.000011385530777770133	0.000011385530777770133	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR
ESTABLISHMENT OF SISTER CHROMATID COHESION%GOBP%GO:0034085	establishment of sister chromatid cohesion	0.000012995966144062965	0.000012995966144062965	+1	STAG2,SMC1A,SMC3,RAD21
ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 81%2468052	Establishment of Sister Chromatid Cohesion	0.000012995966144062965	0.000012995966144062965	+1	STAG2,SMC1A,SMC3,RAD21
VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS	Validated transcriptional targets of deltaNp63 isoforms	0.000012995966144062965	0.000012995966144062965	+1	CDKN2A,NOTCH1,FBXW7,RUNX1,ATM,BRCA2
CELL FATE SPECIFICATION%GOBP%GO:0001708	cell fate specification	0.000012995966144062965	0.000012995966144062965	+1	APC,TBX3,SOX9,SMAD4,FOXA2,SOX17
NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK	Notch-mediated HES HEY network	0.000012995966144062965	0.000012995966144062965	+1	RB1,NOTCH1,AR,CDKN1B,EP300,NCOR1
POSITIVE REGULATION OF PROTEOLYSIS INVOLVED IN PROTEIN CATABOLIC PROCESS%GOBP%GO:1903052	positive regulation of proteolysis involved in protein catabolic process	0.000013406630916274667	0.000013406630916274667	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,AXIN2
TGF BETA SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP366%HOMO SAPIENS	TGF beta signaling pathway	0.000013406630916274667	0.000013406630916274667	+1	MAP2K4,EP300,CCND1,SMAD4,TGFBR2,CDKN1A,SIN3A,SMAD2
MITOTIC DNA INTEGRITY CHECKPOINT SIGNALING%GOBP%GO:0044774	mitotic DNA integrity checkpoint signaling	0.000013406630916274667	0.000013406630916274667	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
SEX DIFFERENTIATION%GOBP%GO:0007548	sex differentiation	0.000014263885102926993	0.000014263885102926993	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,PTPN11
POSITIVE REGULATION OF MIRNA TRANSCRIPTION%GOBP%GO:1902895	positive regulation of miRNA transcription	0.00001434453989476613	0.00001434453989476613	+1	TP53,EGFR,GATA3,AR,WT1,FOXA1
TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 81%8878171	Transcriptional regulation by RUNX1	0.000015074676791653375	0.000015074676791653375	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,CCND1,CBFB,SIN3A,PTPN11,LIFR
SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.000018533052901133368	0.000018533052901133368	+1	PIK3CA,APC,CTNNB1,CDH1,MAP2K4,HGF,PTPN11
MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20240510%WP1545%HOMO SAPIENS	miRNAs involved in DNA damage response	0.000018533052901133368	0.000018533052901133368	+1	ATM,CDKN1B,CCND1,CDKN1A
TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 81%8878166	Transcriptional regulation by RUNX2	0.000020660673742341406	0.000020660673742341406	+1	RB1,RUNX1,AR,SOX9,CCND1,SMAD4,CDKN1A,CBFB
CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 81%2559583	Cellular Senescence	0.000021038518467652895	0.000021038518467652895	+1	TP53,CDKN2A,RB1,MAP2K4,ATM,CDKN1B,CDKN1A,CDKN2C,EZH2
CELLULAR RESPONSE TO UV%GOBP%GO:0034644	cellular response to UV	0.00002145765233760208	0.00002145765233760208	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION%GOBP%GO:0050680	negative regulation of epithelial cell proliferation	0.00002145765233760208	0.00002145765233760208	+1	NF1,GATA3,FBXW7,EPPK1,SOX9,FGFR2,BRCA2
CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME%R-HSA-9711123.5	Cellular response to chemical stress	0.000021625372017975918	0.000021625372017975918	+1	CDKN2A,NOTCH1,KEAP1,NFE2L2,BRCA1,EP300,CDKN1A,SIN3A,TBL1XR1,NCOR1
PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY	PID_ATM_PATHWAY	0.000024013119864663014	0.000024013119864663014	+1	ATM,BRCA1,CHEK2,SMC1A,SMC3
ESTABLISHMENT OF MEIOTIC SISTER CHROMATID COHESION%GOBP%GO:0034089	establishment of meiotic sister chromatid cohesion	0.00002405532541166579	0.00002405532541166579	+1	SMC1A,SMC3,RAD21
SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-HSA-9006936.8	Signaling by TGFB family members	0.00002405532541166579	0.00002405532541166579	+1	EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,NCOR1,SMAD2
REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME%R-HSA-9825892.1	Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	0.000024658785684471838	0.000024658785684471838	+1	CDKN2A,CTNNB1,CCND1,CDKN1A
REGULATION OF CANONICAL WNT SIGNALING PATHWAY%GOBP%GO:0060828	regulation of canonical Wnt signaling pathway	0.000024658785684471838	0.000024658785684471838	+1	APC,EGFR,STK11,SOX9,LRRK2,FGFR2,SMAD4,SOX17,TBL1XR1,AXIN2
NEGATIVE REGULATION OF PROTEIN PHOSPHORYLATION%GOBP%GO:0001933	negative regulation of protein phosphorylation	0.000024658785684471838	0.000024658785684471838	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CDKN1B,LRRK2,CDKN1A,MAPK8IP1
BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY	BIOCARTA_TGFB_PATHWAY	0.000024658785684471838	0.000024658785684471838	+1	EP300,SMAD4,TGFBR2,SMAD2
CELL DIVISION%REACTOME%R-HSA-68884.6	cell division	0.000024658785684471838	0.000024658785684471838	+1	STAG2,SMC1A,SMC3,RAD21
RESPONSE TO LIGHT STIMULUS%GOBP%GO:0009416	response to light stimulus	0.00002550919243831225	0.00002550919243831225	+1	TP53,EGFR,NF1,NPM1,STK11,EP300,CCND1,CDKN1A,TAF1,ATR
POSITIVE REGULATION OF MIRNA METABOLIC PROCESS%GOBP%GO:2000630	positive regulation of miRNA metabolic process	0.00002607400947716333	0.00002607400947716333	+1	TP53,EGFR,GATA3,AR,WT1,FOXA1
CELLULAR RESPONSE TO IONIZING RADIATION%GOBP%GO:0071479	cellular response to ionizing radiation	0.00002607400947716333	0.00002607400947716333	+1	TP53,ATM,BRCA1,BRCA2,CDKN1A,ATR
NOTCH%IOB%NOTCH	Notch	0.00002607400947716333	0.00002607400947716333	+1	NOTCH1,FBXW7,EP300,SMAD4,SIN3A,NCOR1
PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY	PID_ERA_GENOMIC_PATHWAY	0.00002607400947716333	0.00002607400947716333	+1	BRCA1,EP300,CCND1,SMAD4,NCOR1,AXIN2
PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY	PDGFR-beta signaling pathway	0.000029041387582275433	0.000029041387582275433	+1	PIK3CA,PTEN,ARHGAP35,MAP2K4,BRAF,PIK3CG,PPP2R1A,PTPN11
WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20240510%WP399%HOMO SAPIENS	Wnt signaling pathway and pluripotency	0.000029486976502431286	0.000029486976502431286	+1	CTNNB1,MAP2K4,LRRK2,EP300,CCND1,PPP2R1A,AXIN2
APOPTOTIC SIGNALING PATHWAY%GOBP%GO:0097190	apoptotic signaling pathway	0.000030297407612569333	0.000030297407612569333	+1	TP53,STK11,ATM,BRCA1,CHEK2,EP300,SMAD4,FGFR3,CDKN1A,ACVR1B
MEIOTIC SYNAPSIS%REACTOME%R-HSA-1221632.3	Meiotic synapsis	0.00003178249123546212	0.00003178249123546212	+1	STAG2,BRCA1,ATR,SMC1A,SMC3,RAD21
MESENCHYMAL CELL DIFFERENTIATION%GOBP%GO:0048762	mesenchymal cell differentiation	0.0000319950395972978	0.0000319950395972978	+1	NOTCH1,CTNNB1,TBX3,SOX9,HGF,FGFR2,SMAD4,TGFBR2
FORMATION OF AXIAL MESODERM%REACTOME DATABASE ID RELEASE 81%9796292	Formation of axial mesoderm	0.0000319950395972978	0.0000319950395972978	+1	CTNNB1,FOXA1,FOXA2,SMAD2
REGULATION OF ERK1 AND ERK2 CASCADE%GOBP%GO:0070372	regulation of ERK1 and ERK2 cascade	0.0000319950395972978	0.0000319950395972978	+1	EGFR,NOTCH1,FBXW7,BRAF,TLR4,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY	BIOCARTA_P53_PATHWAY	0.0000319950395972978	0.0000319950395972978	+1	RB1,ATM,CCND1,CDKN1A
POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS%GOBP%GO:0045732	positive regulation of protein catabolic process	0.0000319950395972978	0.0000319950395972978	+1	APC,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,LRRK2,TAF1,AXIN2
POSITIVE REGULATION OF T CELL DIFFERENTIATION%GOBP%GO:0045582	positive regulation of T cell differentiation	0.00003304880170987055	0.00003304880170987055	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,TGFBR2,CBFB
OUTFLOW TRACT MORPHOGENESIS%GOBP%GO:0003151	outflow tract morphogenesis	0.00003412149271000706	0.00003412149271000706	+1	NOTCH1,CTNNB1,FGFR2,SMAD4,TGFBR2,SOX17
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4	Regulation of TP53 Activity through Phosphorylation	0.00003767628232271574	0.00003767628232271574	+1	TP53,STK11,ATM,BRCA1,CHEK2,TAF1,ATR
RESPONSE TO IONIZING RADIATION%GOBP%GO:0010212	response to ionizing radiation	0.00003767628232271574	0.00003767628232271574	+1	TP53,STK11,ATM,BRCA1,BRCA2,CDKN1A,ATR
MALE SEX DIFFERENTIATION%GOBP%GO:0046661	male sex differentiation	0.00003767628232271574	0.00003767628232271574	+1	GATA3,TBX3,AR,SOX9,WT1,KIT
HEPATITIS B INFECTION%WIKIPATHWAYS_20240510%WP4666%HOMO SAPIENS	Hepatitis B infection	0.000038596397321520914	0.000038596397321520914	+1	MAP2K4,BRAF,TLR4,EP300,SMAD4,TGFBR2,CDKN1A,SMAD2
ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20240510%WP5293%HOMO SAPIENS	Acute myeloid leukemia	0.0000407314369805228	0.0000407314369805228	+1	FLT3,RUNX1,CEBPA,BRAF,KIT,CCND1
P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY	p53 pathway	0.0000407314369805228	0.0000407314369805228	+1	TP53,CDKN2A,ATM,CHEK2,EP300,ATR
SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME%R-HSA-9703648.2	Signaling by FLT3 ITD and TKD mutants	0.00004151272995858516	0.00004151272995858516	+1	PIK3CA,FLT3,CDKN1A,PTPN11
PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.6	Pre-NOTCH Transcription and Translation	0.00004438880378711307	0.00004438880378711307	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1
PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY	PID_TELOMERASE_PATHWAY	0.00004438880378711307	0.00004438880378711307	+1	EGFR,ATM,CDKN1B,WT1,CCND1,SIN3A
ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY	ATM pathway	0.000046367122457172696	0.000046367122457172696	+1	ATM,BRCA1,CHEK2,SMC1A,SMC3
POSITIVE REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS%GOBP%GO:1901800	positive regulation of proteasomal protein catabolic process	0.000048072712912640126	0.000048072712912640126	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,AXIN2
NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20240510%WP4255%HOMO SAPIENS	Non small cell lung cancer	0.000048072712912640126	0.000048072712912640126	+1	EGFR,CDKN2A,RB1,BRAF,CCND1,CDKN1A
UROTENSIN II MEDIATED SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP5158%HOMO SAPIENS	Urotensin II mediated signaling pathway	0.000048072712912640126	0.000048072712912640126	+1	PTEN,EGFR,CTNNB1,EP300,PTPN11,SMAD2
CELLULAR RESPONSE TO INDOLE-3-METHANOL%GOBP%GO:0071681	cellular response to indole-3-methanol	0.00004910013461642392	0.00004910013461642392	+1	CTNNB1,CDH1,BRCA1
BIOCARTA_PLK3_PATHWAY%MSIGDB_C2%BIOCARTA_PLK3_PATHWAY	BIOCARTA_PLK3_PATHWAY	0.00004910013461642392	0.00004910013461642392	+1	ATM,CHEK2,ATR
RESPONSE TO INDOLE-3-METHANOL%GOBP%GO:0071680	response to indole-3-methanol	0.00004910013461642392	0.00004910013461642392	+1	CTNNB1,CDH1,BRCA1
REGULATION OF CENTROMERIC SISTER CHROMATID COHESION%GOBP%GO:0070602	regulation of centromeric sister chromatid cohesion	0.00004910013461642392	0.00004910013461642392	+1	CTNNB1,CTCF,AXIN2
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 81%8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	0.00004910013461642392	0.00004910013461642392	+1	RUNX1,CBFB,LIFR
RESPONSE TO HYPOXIA%GOBP%GO:0001666	response to hypoxia	0.000050396254405937604	0.000050396254405937604	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,EP300,SMAD4
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 81%6796648	TP53 Regulates Transcription of DNA Repair Genes	0.00005118048253126146	0.00005118048253126146	+1	TP53,ATM,BRCA1,ATR,CDK12,ERCC2
RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 81%8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	0.00005118048253126146	0.00005118048253126146	+1	ARID1A,PBRM1,RUNX1,EP300,CBFB
BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY	BIOCARTA_P53HYPOXIA_PATHWAY	0.00005140882232182788	0.00005140882232182788	+1	ATM,EP300,CDKN1A,TAF1
CELLULAR RESPONSE TO LIGHT STIMULUS%GOBP%GO:0071482	cellular response to light stimulus	0.00005283810915547039	0.00005283810915547039	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
REGULATION OF CELL CYCLE G2/M PHASE TRANSITION%GOBP%GO:1902749	regulation of cell cycle G2/M phase transition	0.000056359355555573055	0.000056359355555573055	+1	TP53,NPM1,ATM,BRCA1,CCND1,CDKN1A,ATR
KIDNEY DEVELOPMENT%GOBP%GO:0001822	kidney development	0.000056852996013866887	0.000056852996013866887	+1	NF1,GATA3,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 81%6804757	Regulation of TP53 Degradation	0.000056852996013866887	0.000056852996013866887	+1	TP53,CDKN2A,ATM,CHEK2,PPP2R1A
ATM SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP2516%HOMO SAPIENS	ATM signaling pathway	0.000056852996013866887	0.000056852996013866887	+1	ATM,BRCA1,CHEK2,CDKN1A,SMC1A
RESPONSE TO DECREASED OXYGEN LEVELS%GOBP%GO:0036293	response to decreased oxygen levels	0.000056852996013866887	0.000056852996013866887	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,EP300,SMAD4
TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 81%8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.000056852996013866887	0.000056852996013866887	+1	EGFR,NPM1,KIT,EP300,CDKN1A
REGULATION OF ORGAN GROWTH%GOBP%GO:0046620	regulation of organ growth	0.000056852996013866887	0.000056852996013866887	+1	PTEN,NOTCH1,RUNX1,WT1,FGFR2
PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20240510%WP2572%HOMO SAPIENS	Primary focal segmental glomerulosclerosis FSGS	0.000059004687468403906	0.000059004687468403906	+1	NOTCH1,CTNNB1,CDKN1B,WT1,TLR4,CDKN1A
EPITHELIAL TUBE MORPHOGENESIS%GOBP%GO:0060562	epithelial tube morphogenesis	0.00006225141692632136	0.00006225141692632136	+1	GATA3,NOTCH1,CTNNB1,SOX9,WT1,FGFR2,TGFBR2,SOX17
NEGATIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	0.00006245826040281455	0.00006245826040281455	+1	PTEN,APC,CDKN2A,CDKN1B
SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5	Signaling by Activin	0.00006245826040281455	0.00006245826040281455	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 81%9617828	FOXO-mediated transcription of cell cycle genes	0.00006245826040281455	0.00006245826040281455	+1	CDKN1B,SMAD4,CDKN1A,SMAD2
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 81%8934593	Regulation of RUNX1 Expression and Activity	0.00006245826040281455	0.00006245826040281455	+1	RUNX1,CCND1,CBFB,PTPN11
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 81%9659787	Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects	0.00006245826040281455	0.00006245826040281455	+1	RB1,CDKN1B,CCND1,CDKN1A
DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME DATABASE ID RELEASE 81%9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	0.00006245826040281455	0.00006245826040281455	+1	RB1,CDKN1B,CCND1,CDKN1A
VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK	Validated nuclear estrogen receptor alpha network	0.00006253524447174924	0.00006253524447174924	+1	BRCA1,EP300,CCND1,SMAD4,NCOR1,AXIN2
REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME DATABASE ID RELEASE 81%6806003	Regulation of TP53 Expression and Degradation	0.0000627149446871103	0.0000627149446871103	+1	TP53,CDKN2A,ATM,CHEK2,PPP2R1A
STEM CELL DIFFERENTIATION%GOBP%GO:0048863	stem cell differentiation	0.00006418225603048687	0.00006418225603048687	+1	TP53,NOTCH1,CTNNB1,SOX9,KIT,SETD2,FGFR2
P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69580.5	p53-Dependent G1 S DNA damage checkpoint	0.00006732470197383387	0.00006732470197383387	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-HSA-69563.5	p53-Dependent G1 DNA Damage Response	0.00006732470197383387	0.00006732470197383387	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
RENAL SYSTEM DEVELOPMENT%GOBP%GO:0072001	renal system development	0.00006921543563183171	0.00006921543563183171	+1	NF1,GATA3,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
PHOSPHATIDYLINOSITOL 3-KINASE/PROTEIN KINASE B SIGNAL TRANSDUCTION%GOBP%GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	0.00006928878517729359	0.00006928878517729359	+1	PIK3CA,PTEN,NF1,GATA3,PIK3CG
MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP382%HOMO SAPIENS	MAPK signaling pathway	0.00006928878517729359	0.00006928878517729359	+1	EGFR,NF1,MAP2K4,BRAF,LRRK2,FGFR2,FGFR3,TGFBR2,MAPK8IP1
PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY	PID_HNF3A_PATHWAY	0.00006928878517729359	0.00006928878517729359	+1	CDKN1B,BRCA1,FOXA1,EP300,FOXA2
DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4	Diseases of mitotic cell cycle	0.00006928878517729359	0.00006928878517729359	+1	RB1,CDKN1B,ATRX,CCND1,CDKN1A
REGULATION OF PROTEOLYSIS INVOLVED IN PROTEIN CATABOLIC PROCESS%GOBP%GO:1903050	regulation of proteolysis involved in protein catabolic process	0.00006928878517729359	0.00006928878517729359	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,AXIN2
POSITIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION%GOBP%GO:0045621	positive regulation of lymphocyte differentiation	0.0000705717060079281	0.0000705717060079281	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,TGFBR2,CBFB
PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY	PID_BETA_CATENIN_NUC_PATHWAY	0.00007125208609878736	0.00007125208609878736	+1	CDKN2A,CTNNB1,EP300,CCND1,TBL1XR1,AXIN2
BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY	BIOCARTA_ATM_PATHWAY	0.00007552534837672946	0.00007552534837672946	+1	ATM,BRCA1,CHEK2,CDKN1A
G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.4	G1 S DNA Damage Checkpoints	0.00007714103966736156	0.00007714103966736156	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
RAS SIGNALING%WIKIPATHWAYS_20240510%WP4223%HOMO SAPIENS	Ras signaling	0.00007746165209719728	0.00007746165209719728	+1	EGFR,NF1,FLT3,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
CARDIAC ENDOTHELIAL CELL DIFFERENTIATION%GOBP%GO:0003348	cardiac endothelial cell differentiation	0.00008182635078300702	0.00008182635078300702	+1	NOTCH1,SMAD4,SOX17
ENDOCARDIAL CELL DIFFERENTIATION%GOBP%GO:0060956	endocardial cell differentiation	0.00008182635078300702	0.00008182635078300702	+1	NOTCH1,SMAD4,SOX17
REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE	Regulation of Telomerase	0.00008182635078300702	0.00008182635078300702	+1	EGFR,ATM,CDKN1B,WT1,CCND1,SIN3A
LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 81%3304349	Loss of Function of SMAD2 3 in Cancer	0.00008182635078300702	0.00008182635078300702	+1	SMAD4,TGFBR2,SMAD2
PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20240510%WP2253%HOMO SAPIENS	Pilocytic astrocytoma	0.00008182635078300702	0.00008182635078300702	+1	NF1,BRAF,PTPN11
POSITIVE REGULATION OF DNA-BINDING TRANSCRIPTION FACTOR ACTIVITY%GOBP%GO:0051091	positive regulation of DNA-binding transcription factor activity	0.00008182635078300702	0.00008182635078300702	+1	PTEN,NPM1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,TAF1
SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7	Signaling by NOTCH	0.00008182635078300702	0.00008182635078300702	+1	TP53,EGFR,NOTCH1,RUNX1,ELF3,EP300,CCND1,TBL1XR1,NCOR1
POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY%GOBP%GO:0010518	positive regulation of phospholipase activity	0.0000855123690592289	0.0000855123690592289	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
RESPONSE TO MECHANICAL STIMULUS%GOBP%GO:0009612	response to mechanical stimulus	0.00008652814794870466	0.00008652814794870466	+1	PIK3CA,CTNNB1,MAP2K4,SOX9,TLR4,KIT,ATR
CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS	CDC42 signaling events	0.00008769909013597314	0.00008769909013597314	+1	PIK3CA,APC,CTNNB1,CDH1,MAP2K4,BRAF
POSITIVE REGULATION OF T CELL ACTIVATION%GOBP%GO:0050870	positive regulation of T cell activation	0.00008991110909713917	0.00008991110909713917	+1	PIK3CA,ARID1A,PBRM1,GATA3,RUNX1,EP300,TGFBR2,CBFB,PTPN11
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3	Regulation of TP53 Activity through Methylation	0.00008991110909713917	0.00008991110909713917	+1	TP53,ATM,CHEK2,EP300
DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 81%5693532	DNA Double-Strand Break Repair	0.00008991110909713917	0.00008991110909713917	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,BRCA2,ATR
UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 81%5689880	Ub-specific processing proteases	0.00009265904050866236	0.00009265904050866236	+1	TP53,PTEN,GATA3,KEAP1,AR,SMAD4,USP9X,SMAD2,AXIN2
PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY	PID_HES_HEY_PATHWAY	0.0000933771574080433	0.0000933771574080433	+1	RB1,NOTCH1,CDKN1B,EP300,NCOR1
METANEPHROS DEVELOPMENT%GOBP%GO:0001656	metanephros development	0.0000933771574080433	0.0000933771574080433	+1	NF1,SOX9,WT1,PDGFRA,SOX17
VENTRICULAR SEPTUM DEVELOPMENT%GOBP%GO:0003281	ventricular septum development	0.0000933771574080433	0.0000933771574080433	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4	SUMOylation of DNA damage response and repair proteins	0.0000933771574080433	0.0000933771574080433	+1	CDKN2A,STAG2,BRCA1,SMC1A,SMC3,RAD21
EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 81%212165	Epigenetic regulation of gene expression	0.00009645946939130295	0.00009645946939130295	+1	DNMT3A,KDM6A,TET2,EP300,SF3B1,SIN3A,ERCC2,EZH2
HALLMARK_G2M_CHECKPOINT%MSIGDBHALLMARK%HALLMARK_G2M_CHECKPOINT	HALLMARK_G2M_CHECKPOINT	0.00009645946939130295	0.00009645946939130295	+1	CTCF,CDKN1B,CCND1,BRCA2,SMC1A,RAD21,CDKN2C,EZH2
CARDIOCYTE DIFFERENTIATION%GOBP%GO:0035051	cardiocyte differentiation	0.00009898982646522905	0.00009898982646522905	+1	NOTCH1,TBX3,WT1,PDGFRA,SMAD4,SOX17
DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20240510%WP4016%HOMO SAPIENS	DNA IR damage and cellular response via ATR	0.00009898982646522905	0.00009898982646522905	+1	ATM,BRCA1,CHEK2,BRCA2,ATR,SMC1A
HEART DEVELOPMENT%WIKIPATHWAYS_20240510%WP1591%HOMO SAPIENS	Heart development	0.00010284642414114371	0.00010284642414114371	+1	NOTCH1,CTNNB1,SMAD4,FOXA2,PTPN11
HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20240510%WP3646%HOMO SAPIENS	Hepatitis C and hepatocellular carcinoma	0.00010284642414114371	0.00010284642414114371	+1	BRCA1,CCND1,SMAD4,CDKN1A,PTPN11
ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20240510%WP3878%HOMO SAPIENS	ATM signaling in development and disease	0.00010284642414114371	0.00010284642414114371	+1	STK11,ATM,CHEK2,ATR,SMC1A
MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.1	MITF-M-regulated melanocyte development	0.00010348032074901744	0.00010348032074901744	+1	ARID1A,CDKN2A,CTNNB1,KIT,CCND1,CDKN1A,SIN3A
RESPONSE TO OXYGEN LEVELS%GOBP%GO:0070482	response to oxygen levels	0.00010348032074901744	0.00010348032074901744	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,EP300,SMAD4
ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP673%HOMO SAPIENS	ErbB signaling pathway	0.00010504505487988137	0.00010504505487988137	+1	EGFR,MAP2K4,BRAF,CDKN1B,CCND1,CDKN1A
BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20240510%WP3927%HOMO SAPIENS	BMP signaling in eyelid development	0.00010558526079449895	0.00010558526079449895	+1	EGFR,NOTCH1,FGFR2,SMAD4
POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE%GOBP%GO:0070374	positive regulation of ERK1 and ERK2 cascade	0.0001073358463934233	0.0001073358463934233	+1	EGFR,NOTCH1,FBXW7,BRAF,PDGFRA,FGFR2,FGFR3,PTPN11
MAPK CASCADE%GOBP%GO:0000165	MAPK cascade	0.0001081961792498077	0.0001081961792498077	+1	NF1,MAP2K4,BRAF,SOX9,LRRK2,FGFR3,MAPK8IP1
EMBRYONIC ORGAN DEVELOPMENT%GOBP%GO:0048568	embryonic organ development	0.00012343290335707708	0.00012343290335707708	+1	GATA3,NOTCH1,CTNNB1,SOX9,KIT,PDGFRA,FGFR2,TGFBR2,SOX17
EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0007173	epidermal growth factor receptor signaling pathway	0.000126400470613057	0.000126400470613057	+1	PIK3CA,EGFR,BRAF,SOX9,PTPN11
FOCAL ADHESION%WIKIPATHWAYS_20240510%WP306%HOMO SAPIENS	Focal adhesion	0.00012737372415901117	0.00012737372415901117	+1	PTEN,EGFR,CTNNB1,ARHGAP35,BRAF,HGF,PDGFRA,CCND1
RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 81%8941855	RUNX3 regulates CDKN1A transcription	0.00012834613781922808	0.00012834613781922808	+1	TP53,SMAD4,CDKN1A
SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.4	Signaling by TGF-beta Receptor Complex in Cancer	0.00012834613781922808	0.00012834613781922808	+1	SMAD4,TGFBR2,SMAD2
PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%R-HSA-1912422.3	Pre-NOTCH Expression and Processing	0.00012834613781922808	0.00012834613781922808	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1
POSITIVE REGULATION OF MAP KINASE ACTIVITY%GOBP%GO:0043406	positive regulation of MAP kinase activity	0.00012834613781922808	0.00012834613781922808	+1	EGFR,FLT3,PIK3CG,TLR4,LRRK2,EZH2
S PHASE%REACTOME DATABASE ID RELEASE 81%69242	S Phase	0.00013709016752437597	0.00013709016752437597	+1	RB1,STAG2,CDKN1B,CCND1,CDKN1A,SMC1A,SMC3,RAD21
POSITIVE REGULATION OF PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0071902	positive regulation of protein serine/threonine kinase activity	0.0001475224197905033	0.0001475224197905033	+1	EGFR,FLT3,PIK3CG,TLR4,LRRK2,CCND1,EZH2
HALLMARK_UV_RESPONSE_DN%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_DN	HALLMARK_UV_RESPONSE_DN	0.0001475224197905033	0.0001475224197905033	+1	PTEN,RUNX1,CDKN1B,KIT,TGFBR2,ACVR2A,SPOP
ATRIOVENTRICULAR VALVE MORPHOGENESIS%GOBP%GO:0003181	atrioventricular valve morphogenesis	0.00015049914686824352	0.00015049914686824352	+1	NOTCH1,SMAD4,TGFBR2,AXIN2
FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20240510%WP4790%HOMO SAPIENS	FGF23 signaling in hypophosphatemic rickets and related disorders	0.00015049914686824352	0.00015049914686824352	+1	FGFR2,CCND1,FGFR3,CDKN1A
FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY	FGF signaling pathway	0.00015167101319522603	0.00015167101319522603	+1	PIK3CA,CDH1,FGFR2,FGFR3,PTPN11
HEME SIGNALING%REACTOME%R-HSA-9707616.4	Heme signaling	0.00015167101319522603	0.00015167101319522603	+1	NFE2L2,TLR4,EP300,TBL1XR1,NCOR1
REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS%GOBP%GO:0061136	regulation of proteasomal protein catabolic process	0.00015304629473932845	0.00015304629473932845	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,AXIN2
MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.1	MITF-M-dependent gene expression	0.0001559427104396201	0.0001559427104396201	+1	ARID1A,CDKN2A,CTNNB1,CCND1,CDKN1A,SIN3A
BLOOD VESSEL MORPHOGENESIS%GOBP%GO:0048514	blood vessel morphogenesis	0.00016883198817497832	0.00016883198817497832	+1	NF1,NOTCH1,CTNNB1,WT1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
POSITIVE REGULATION OF LEUKOCYTE CELL-CELL ADHESION%GOBP%GO:1903039	positive regulation of leukocyte cell-cell adhesion	0.00016883198817497832	0.00016883198817497832	+1	PIK3CA,ARID1A,PBRM1,GATA3,RUNX1,EP300,TGFBR2,CBFB,PTPN11
MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:0002009	morphogenesis of an epithelium	0.0001744444752725953	0.0001744444752725953	+1	GATA3,NOTCH1,CTNNB1,ARHGAP35,SOX9,WT1,FGFR2,TGFBR2,SOX17
SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3	Signaling by NODAL	0.00017488491712842227	0.00017488491712842227	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY	BIOCARTA_RACCYCD_PATHWAY	0.00017488491712842227	0.00017488491712842227	+1	RB1,CDKN1B,CCND1,CDKN1A
MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20240510%WP4842%HOMO SAPIENS	Mammalian disorder of sexual development	0.00017488491712842227	0.00017488491712842227	+1	CTNNB1,SOX9,WT1,FGFR2
WNT BETA CATENIN SIGNALING PATHWAY IN LEUKEMIA%WIKIPATHWAYS_20240510%WP3658%HOMO SAPIENS	Wnt beta catenin signaling pathway in leukemia	0.00017488491712842227	0.00017488491712842227	+1	CTNNB1,FLT3,CCND1,AXIN2
INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:0097193	intrinsic apoptotic signaling pathway	0.00017535094582987433	0.00017535094582987433	+1	TP53,STK11,ATM,BRCA1,CHEK2,EP300,CDKN1A
REPLICATION FORK PROCESSING%GOBP%GO:0031297	replication fork processing	0.00018040080415470238	0.00018040080415470238	+1	ATRX,BRCA1,POLQ,BRCA2,ATR
REGULATION OF FIBROBLAST PROLIFERATION%GOBP%GO:0048145	regulation of fibroblast proliferation	0.00018040080415470238	0.00018040080415470238	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION PART 3 OF 3%WIKIPATHWAYS_20240510%WP2840%HOMO SAPIENS	Hair follicle development cytodifferentiation part 3 of 3	0.00018670108362672428	0.00018670108362672428	+1	EGFR,GATA3,NOTCH1,CTNNB1,SOX9,SMAD4
REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME%R-HSA-9818749.3	Regulation of NFE2L2 gene expression	0.0001890522215804197	0.0001890522215804197	+1	NOTCH1,NFE2L2,EP300
ENDOCARDIUM DEVELOPMENT%GOBP%GO:0003157	endocardium development	0.0001890522215804197	0.0001890522215804197	+1	NOTCH1,SMAD4,SOX17
KEAP1-NFE2L2 PATHWAY%REACTOME DATABASE ID RELEASE 81%9755511	KEAP1-NFE2L2 pathway	0.00019134899284860326	0.00019134899284860326	+1	CDKN2A,NOTCH1,KEAP1,NFE2L2,BRCA1,EP300,CDKN1A
CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20240510%WP2406%HOMO SAPIENS	Cardiac progenitor differentiation	0.00019466095962579643	0.00019466095962579643	+1	NOTCH1,KIT,PDGFRA,FOXA2,SOX17
MORPHOGENESIS OF A BRANCHING EPITHELIUM%GOBP%GO:0061138	morphogenesis of a branching epithelium	0.00019466095962579643	0.00019466095962579643	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
REGULATION OF PHOSPHOLIPASE ACTIVITY%GOBP%GO:0010517	regulation of phospholipase activity	0.00019466095962579643	0.00019466095962579643	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.5	TP53 Regulates Transcription of Cell Cycle Genes	0.00019466095962579643	0.00019466095962579643	+1	TP53,NPM1,CDKN1B,EP300,CDKN1A
GONAD DEVELOPMENT%GOBP%GO:0008406	gonad development	0.00019466095962579643	0.00019466095962579643	+1	GATA3,AR,SOX9,WT1,KIT,PDGFRA
PROTEIN LOCALIZATION TO CHROMOSOME%GOBP%GO:0034502	protein localization to chromosome	0.00019466095962579643	0.00019466095962579643	+1	RB1,CTCF,ATRX,BRCA2,ATR,RAD21
PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY	PID_P53_DOWNSTREAM_PATHWAY	0.00019731127903802704	0.00019731127903802704	+1	PTEN,EGFR,RB1,HGF,FOXA1,EP300,CDKN1A
TYPE 2 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20240510%WP4241%HOMO SAPIENS	Type 2 papillary renal cell carcinoma	0.00019923239147394116	0.00019923239147394116	+1	VHL,SETD2,EP300,CDKN1A
SPINDLE ASSEMBLY%GOBP%GO:0051225	spindle assembly	0.00020665221250239826	0.00020665221250239826	+1	PTEN,STAG2,CHEK2,SMC1A,SMC3,NCOR1
PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY	PID_P53_REGULATION_PATHWAY	0.00020964241308890215	0.00020964241308890215	+1	CDKN2A,ATM,CHEK2,EP300,ATR
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6	Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer	0.00020964241308890215	0.00020964241308890215	+1	EP300,SMAD4,USP9X,NCOR1,SMAD2
INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE%GOBP%GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	0.00020964241308890215	0.00020964241308890215	+1	TP53,ATM,BRCA1,CHEK2,EP300
POSITIVE REGULATION OF LIPASE ACTIVITY%GOBP%GO:0060193	positive regulation of lipase activity	0.00020964241308890215	0.00020964241308890215	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052	TGF-beta signaling pathway	0.000217227507765423	0.000217227507765423	+1	EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS%GOBP%GO:0045137	development of primary sexual characteristics	0.000217227507765423	0.000217227507765423	+1	GATA3,AR,SOX9,WT1,KIT,PDGFRA
REGULATION OF LEUKOCYTE DIFFERENTIATION%GOBP%GO:1902105	regulation of leukocyte differentiation	0.00022630973897015542	0.00022630973897015542	+1	ARID1A,PBRM1,GATA3,FBXW7,RUNX1,TLR4,EP300,TGFBR2,CBFB
SIGNALING BY PTK6%REACTOME%R-HSA-8848021.4	Signaling by PTK6	0.00022630973897015542	0.00022630973897015542	+1	EGFR,ARHGAP35,CDKN1B,LRRK2,CCND1
SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006927.5	Signaling by Non-Receptor Tyrosine Kinases	0.00022630973897015542	0.00022630973897015542	+1	EGFR,ARHGAP35,CDKN1B,LRRK2,CCND1
TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20240510%WP560%HOMO SAPIENS	TGF beta receptor signaling	0.00022630973897015542	0.00022630973897015542	+1	CTNNB1,EP300,SMAD4,TGFBR2,SMAD2
ATRIOVENTRICULAR VALVE DEVELOPMENT%GOBP%GO:0003171	atrioventricular valve development	0.00022630973897015542	0.00022630973897015542	+1	NOTCH1,SMAD4,TGFBR2,AXIN2
MIRNA REGULATION OF PROSTATE CANCER SIGNALING PATHWAYS%WIKIPATHWAYS_20240510%WP3981%HOMO SAPIENS	miRNA regulation of prostate cancer signaling pathways	0.00022630973897015542	0.00022630973897015542	+1	CTNNB1,CDKN1B,CCND1,CDKN1A
REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE%GOBP%GO:0060688	regulation of morphogenesis of a branching structure	0.00022630973897015542	0.00022630973897015542	+1	SOX9,HGF,LRRK2,FGFR2
PATTERN SPECIFICATION PROCESS%GOBP%GO:0007389	pattern specification process	0.00023840855973134004	0.00023840855973134004	+1	APC,NOTCH1,TBX3,WT1,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
SKELETAL SYSTEM MORPHOGENESIS%GOBP%GO:0048705	skeletal system morphogenesis	0.0002417324224076977	0.0002417324224076977	+1	CTNNB1,SOX9,PDGFRA,FGFR2,FGFR3,TGFBR2
MALE GONAD DEVELOPMENT%GOBP%GO:0008584	male gonad development	0.00024496586005551805	0.00024496586005551805	+1	GATA3,AR,SOX9,WT1,KIT
REGULATION OF EPITHELIAL CELL PROLIFERATION%GOBP%GO:0050678	regulation of epithelial cell proliferation	0.00024496586005551805	0.00024496586005551805	+1	EGFR,NF1,GATA3,FBXW7,EPPK1,SOX9,FGFR2,BRCA2,EGR3
REGULATION OF T CELL DIFFERENTIATION%GOBP%GO:0045580	regulation of T cell differentiation	0.0002521914581044037	0.0002521914581044037	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,TGFBR2,CBFB
EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018	EGF receptor signaling pathway	0.00025511358411847885	0.00025511358411847885	+1	PIK3CA,EGFR,NF1,MAP2K4,BRAF,PIK3CG
REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS%GOBP%GO:2000136	regulation of cell proliferation involved in heart morphogenesis	0.0002578674828974185	0.0002578674828974185	+1	NOTCH1,TBX3,SMAD4
REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION%GOBP%GO:1903053	regulation of extracellular matrix organization	0.00026451508647915673	0.00026451508647915673	+1	RB1,NOTCH1,RUNX1,SMAD4,AXIN2
DEVELOPMENT OF URETERIC COLLECTION SYSTEM%WIKIPATHWAYS_20240510%WP5053%HOMO SAPIENS	Development of ureteric collection system	0.00026451508647915673	0.00026451508647915673	+1	GATA3,CTNNB1,WT1,FGFR2,CCND1
DEVELOPMENT OF PRIMARY MALE SEXUAL CHARACTERISTICS%GOBP%GO:0046546	development of primary male sexual characteristics	0.00026451508647915673	0.00026451508647915673	+1	GATA3,AR,SOX9,WT1,KIT
DEVELOPMENTAL GROWTH%GOBP%GO:0048589	developmental growth	0.00027268496359059504	0.00027268496359059504	+1	NOTCH1,CTNNB1,RUNX1,SOX9,FGFR2,USP9X,FGFR3
GROWTH%GOBP%GO:0040007	growth	0.00027268496359059504	0.00027268496359059504	+1	NOTCH1,CTNNB1,RUNX1,SOX9,FGFR2,USP9X,FGFR3
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.00028275912064814837	0.00028275912064814837	+1	CTCF,KDM6A,AJUBA,EP300,NCOR1,EZH2
ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME DATABASE ID RELEASE 81%5619507	Activation of HOX genes during differentiation	0.00028275912064814837	0.00028275912064814837	+1	CTCF,KDM6A,AJUBA,EP300,NCOR1,EZH2
REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:1901796	regulation of signal transduction by p53 class mediator	0.00028275912064814837	0.00028275912064814837	+1	STK11,ATM,CHEK2,EP300,TAF1,ATR
CARDIAC VENTRICLE MORPHOGENESIS%GOBP%GO:0003208	cardiac ventricle morphogenesis	0.00028356539079682985	0.00028356539079682985	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20240510%WP4816%HOMO SAPIENS	TGF beta receptor signaling in skeletal dysplasias	0.00028356539079682985	0.00028356539079682985	+1	CTNNB1,EP300,SMAD4,TGFBR2,SMAD2
MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20240510%WP5236%HOMO SAPIENS	Markers of kidney cell lineage	0.00028356539079682985	0.00028356539079682985	+1	NOTCH1,CTNNB1,WT1,KIT,AXIN2
ACTIVIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0032924	activin receptor signaling pathway	0.0002912271540999465	0.0002912271540999465	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS PART 2 OF 3%WIKIPATHWAYS_20240510%WP2839%HOMO SAPIENS	Hair follicle development organogenesis part 2 of 3	0.0002912271540999465	0.0002912271540999465	+1	CTNNB1,PDGFRA,FGFR2,CCND1
TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20240510%WP4204%HOMO SAPIENS	Tumor suppressor activity of SMARCB1	0.0002912271540999465	0.0002912271540999465	+1	ARID1A,CDKN2A,RB1,EZH2
FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3	FLT3 signaling in disease	0.0002912271540999465	0.0002912271540999465	+1	PIK3CA,FLT3,CDKN1A,PTPN11
EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20240510%WP4239%HOMO SAPIENS	Epithelial to mesenchymal transition in colorectal cancer	0.0002912271540999465	0.0002912271540999465	+1	NOTCH1,CTNNB1,MAP2K4,SMAD4,TGFBR2,SMAD2,EZH2
SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4	Signaling by TGF-beta Receptor Complex	0.0002937286847959775	0.0002937286847959775	+1	EP300,SMAD4,USP9X,TGFBR2,NCOR1,SMAD2
EMBRYONIC ORGAN MORPHOGENESIS%GOBP%GO:0048562	embryonic organ morphogenesis	0.00030274932089327235	0.00030274932089327235	+1	NOTCH1,CTNNB1,SOX9,PDGFRA,FGFR2,TGFBR2,SOX17
ERBB SIGNALING PATHWAY%GOBP%GO:0038127	ERBB signaling pathway	0.00030274932089327235	0.00030274932089327235	+1	PIK3CA,EGFR,BRAF,SOX9,PTPN11
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-HSA-9616222.3	Transcriptional regulation of granulopoiesis	0.00030274932089327235	0.00030274932089327235	+1	RUNX1,CEBPA,EP300,CDKN1A,CBFB
HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDBHALLMARK%HALLMARK_PI3K_AKT_MTOR_SIGNALING	HALLMARK_PI3K_AKT_MTOR_SIGNALING	0.0003288622726283553	0.0003288622726283553	+1	PTEN,EGFR,CDKN1B,CDKN1A,PTPN11,SMAD2
MORPHOGENESIS OF A BRANCHING STRUCTURE%GOBP%GO:0001763	morphogenesis of a branching structure	0.0003289737606455054	0.0003289737606455054	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS	BARD1 signaling events	0.00033171687931661797	0.00033171687931661797	+1	TP53,ATM,BRCA1,ATR
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2	STAT5 activation downstream of FLT3 ITD mutants	0.0003393056015740204	0.0003393056015740204	+1	FLT3,CDKN1A,PTPN11
REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20240510%WP4240%HOMO SAPIENS	Regulation of sister chromatid separation at the metaphase anaphase transition	0.0003393056015740204	0.0003393056015740204	+1	SMC1A,SMC3,RAD21
BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773	BTG Family Proteins and Cell Cycle Regulation	0.0003393056015740204	0.0003393056015740204	+1	TP53,RB1,CCND1
H19 ACTION RB E2F1 SIGNALING AND CDK BETA CATENIN ACTIVITY%WIKIPATHWAYS_20240510%WP3969%HOMO SAPIENS	H19 action Rb E2F1 signaling and CDK Beta catenin activity	0.0003393056015740204	0.0003393056015740204	+1	RB1,CTNNB1,CCND1
POSITIVE REGULATION OF MESENCHYMAL CELL PROLIFERATION%GOBP%GO:0002053	positive regulation of mesenchymal cell proliferation	0.0003393056015740204	0.0003393056015740204	+1	SOX9,FGFR2,TGFBR2
DNA-TEMPLATED DNA REPLICATION MAINTENANCE OF FIDELITY%GOBP%GO:0045005	DNA-templated DNA replication maintenance of fidelity	0.0003493338640428389	0.0003493338640428389	+1	ATRX,BRCA1,POLQ,BRCA2,ATR
PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20240510%WP3680%HOMO SAPIENS	Physico chemical features and toxicity associated pathways	0.0003493338640428389	0.0003493338640428389	+1	EGFR,CTNNB1,MAP2K4,CDKN1B,CDKN1A
DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS%GOBP%GO:0060560	developmental growth involved in morphogenesis	0.0003493338640428389	0.0003493338640428389	+1	NOTCH1,CTNNB1,SOX9,FGFR2,USP9X
REGULATION OF MYOBLAST DIFFERENTIATION%GOBP%GO:0045661	regulation of myoblast differentiation	0.0003493338640428389	0.0003493338640428389	+1	ARID1A,PBRM1,NOTCH1,TBX3,SOX9
NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20240510%WP2064%HOMO SAPIENS	Neural crest differentiation	0.00035943363566007675	0.00035943363566007675	+1	NOTCH1,CTNNB1,SOX9,FGFR2,FGFR3,AXIN2
DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6	Downregulation of SMAD2 3:SMAD4 transcriptional activity	0.00037089347316908325	0.00037089347316908325	+1	SMAD4,USP9X,NCOR1,SMAD2
REGULATION OF HEART GROWTH%GOBP%GO:0060420	regulation of heart growth	0.00037089347316908325	0.00037089347316908325	+1	NOTCH1,RUNX1,WT1,FGFR2
SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE	Signaling events mediated by focal adhesion kinase	0.00037640400460776973	0.00037640400460776973	+1	PIK3CA,ARHGAP35,MAP2K4,BRAF,CCND1
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.5	DNA Damage Telomere Stress Induced Senescence	0.00040813256850294883	0.00040813256850294883	+1	TP53,RB1,ATM,CDKN1B,CDKN1A
PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20240510%WP5316%HOMO SAPIENS	Primary ovarian insufficiency	0.00041379545893383446	0.00041379545893383446	+1	PTEN,ATM,WT1,BRCA1,KIT,BRCA2,TGFBR2
POSITIVE REGULATION OF HEMOPOIESIS%GOBP%GO:1903708	positive regulation of hemopoiesis	0.00041379545893383446	0.00041379545893383446	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,TGFBR2,CBFB
POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION%GOBP%GO:1902107	positive regulation of leukocyte differentiation	0.00041379545893383446	0.00041379545893383446	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,TGFBR2,CBFB
OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20240510%WP4787%HOMO SAPIENS	Osteoblast differentiation and related diseases	0.0004166453092063788	0.0004166453092063788	+1	NOTCH1,CTNNB1,SOX9,FGFR2,SMAD4,FGFR3
VENTRICULAR SEPTUM MORPHOGENESIS%GOBP%GO:0060412	ventricular septum morphogenesis	0.0004166453092063788	0.0004166453092063788	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
PRION DISEASE PATHWAY%WIKIPATHWAYS_20240510%WP3995%HOMO SAPIENS	Prion disease pathway	0.0004166453092063788	0.0004166453092063788	+1	CTCF,EP300,SMC3,RAD21
RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 81%8941326	RUNX2 regulates bone development	0.0004166453092063788	0.0004166453092063788	+1	RB1,AR,SMAD4,CBFB
MEIOTIC SISTER CHROMATID COHESION%GOBP%GO:0051177	meiotic sister chromatid cohesion	0.0004310913867075054	0.0004310913867075054	+1	SMC1A,SMC3,RAD21
TGF SMAD SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP5382%HOMO SAPIENS	TGF Smad signaling pathway	0.0004310913867075054	0.0004310913867075054	+1	SMAD4,TGFBR2,SMAD2
DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 81%9697154	Disorders of Nervous System Development	0.0004310913867075054	0.0004310913867075054	+1	SIN3A,TBL1XR1,NCOR1
RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693565.6	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.0004310913867075054	0.0004310913867075054	+1	TP53,BAP1,ATM,BRCA1,CHEK2
NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME DATABASE ID RELEASE 81%9818030	NFE2L2 regulating tumorigenic genes	0.0004310913867075054	0.0004310913867075054	+1	NOTCH1,NFE2L2,EP300
DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.4	Disorders of Developmental Biology	0.0004310913867075054	0.0004310913867075054	+1	SIN3A,TBL1XR1,NCOR1
PEPTIDYL-TYROSINE PHOSPHORYLATION%GOBP%GO:0018108	peptidyl-tyrosine phosphorylation	0.0004310913867075054	0.0004310913867075054	+1	EGFR,FLT3,EPHA3,PDGFRA,FGFR2
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 81%9005891	Loss of function of MECP2 in Rett syndrome	0.0004310913867075054	0.0004310913867075054	+1	SIN3A,TBL1XR1,NCOR1
COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY	Coregulation of Androgen receptor activity	0.0004310913867075054	0.0004310913867075054	+1	CDKN2A,CTNNB1,AR,BRCA1,CCND1
PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 81%9005895	Pervasive developmental disorders	0.0004310913867075054	0.0004310913867075054	+1	SIN3A,TBL1XR1,NCOR1
PEPTIDYL-TYROSINE MODIFICATION%GOBP%GO:0018212	peptidyl-tyrosine modification	0.00044751618481031605	0.00044751618481031605	+1	EGFR,FLT3,EPHA3,PDGFRA,FGFR2
CELLULAR RESPONSE TO CHEMICAL STRESS%GOBP%GO:0062197	cellular response to chemical stress	0.00044751618481031605	0.00044751618481031605	+1	TP53,PIK3CA,EGFR,KEAP1,NFE2L2,ATM,LRRK2,PDGFRA
DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.4	DNA Double Strand Break Response	0.00044751618481031605	0.00044751618481031605	+1	TP53,BAP1,ATM,BRCA1,CHEK2
COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20240510%WP5117%HOMO SAPIENS	Cohesin complex Cornelia de Lange syndrome	0.00044898271399362475	0.00044898271399362475	+1	PPP2R1A,SMC1A,SMC3,RAD21
ORGAN GROWTH%GOBP%GO:0035265	organ growth	0.00044898271399362475	0.00044898271399362475	+1	NOTCH1,SOX9,FGFR2,FGFR3
MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 81%453279	Mitotic G1 phase and G1 S transition	0.0004597605740680238	0.0004597605740680238	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
NEGATIVE REGULATION OF CELL DEVELOPMENT%GOBP%GO:0010721	negative regulation of cell development	0.00047878521840803245	0.00047878521840803245	+1	PTEN,NF1,NOTCH1,FBXW7,RUNX1,TLR4,CBFB
PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY	PID_PDGFRB_PATHWAY	0.0004884780421402531	0.0004884780421402531	+1	PTEN,ARHGAP35,MAP2K4,BRAF,PPP2R1A,PTPN11
REGULATION OF DNA BIOSYNTHETIC PROCESS%GOBP%GO:2000278	regulation of DNA biosynthetic process	0.0004884780421402531	0.0004884780421402531	+1	TP53,CTNNB1,ATM,HGF,CDKN1A,ATR
SIGNALING BY FGFR3%REACTOME%R-HSA-5654741.4	Signaling by FGFR3	0.0005045383578990651	0.0005045383578990651	+1	PIK3CA,BRAF,PPP2R1A,PTPN11
CARDIAC SEPTUM DEVELOPMENT%GOBP%GO:0003279	cardiac septum development	0.000511159568490409	0.000511159568490409	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS%GOBP%GO:2000377	regulation of reactive oxygen species metabolic process	0.000511159568490409	0.000511159568490409	+1	TP53,TLR4,BRCA1,LRRK2,TGFBR2,CDKN1A
SPINAL CORD INJURY%WIKIPATHWAYS_20240510%WP2431%HOMO SAPIENS	Spinal cord injury	0.000511159568490409	0.000511159568490409	+1	EGFR,RB1,SOX9,CDKN1B,TLR4,CCND1
PROTEIN STABILIZATION%GOBP%GO:0050821	protein stabilization	0.0005178171735301086	0.0005178171735301086	+1	PTEN,VHL,FBXW7,CHEK2,EP300,USP9X,SOX17,TAF1
ATRIOVENTRICULAR CANAL DEVELOPMENT%GOBP%GO:0036302	atrioventricular canal development	0.0005412850331219642	0.0005412850331219642	+1	TBX3,SMAD4,PTPN11
NEGATIVE REGULATION OF GENE EXPRESSION VIA CHROMOSOMAL CPG ISLAND METHYLATION%GOBP%GO:0044027	negative regulation of gene expression via chromosomal CpG island methylation	0.0005412850331219642	0.0005412850331219642	+1	DNMT3A,WT1,BRCA1
RHYTHMIC BEHAVIOR%GOBP%GO:0007622	rhythmic behavior	0.0005412850331219642	0.0005412850331219642	+1	TP53,PTEN,NCOR1
CIRCADIAN BEHAVIOR%GOBP%GO:0048512	circadian behavior	0.0005412850331219642	0.0005412850331219642	+1	TP53,PTEN,NCOR1
REGULATION OF LIPASE ACTIVITY%GOBP%GO:0060191	regulation of lipase activity	0.0005438585264883572	0.0005438585264883572	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
REGIONALIZATION%GOBP%GO:0003002	regionalization	0.0005466262003205182	0.0005466262003205182	+1	NOTCH1,TBX3,WT1,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 81%2559585	Oncogene Induced Senescence	0.0005541496416678722	0.0005541496416678722	+1	TP53,CDKN2A,RB1,CDKN2C
NEGATIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0010719	negative regulation of epithelial to mesenchymal transition	0.0005541496416678722	0.0005541496416678722	+1	PTEN,GATA3,FOXA1,FOXA2
POSITIVE REGULATION OF DNA REPLICATION%GOBP%GO:0045740	positive regulation of DNA replication	0.0005541496416678722	0.0005541496416678722	+1	EGFR,CDKN1B,ATRX,CDKN1A
REGULATION OF LYMPHOCYTE DIFFERENTIATION%GOBP%GO:0045619	regulation of lymphocyte differentiation	0.0005912122287149237	0.0005912122287149237	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,TGFBR2,CBFB
CANONICAL WNT SIGNALING PATHWAY%GOBP%GO:0060070	canonical Wnt signaling pathway	0.0006692182437991393	0.0006692182437991393	+1	PTEN,GATA3,CTNNB1,LRRK2,AXIN2
IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 81%9709570	Impaired BRCA2 binding to RAD51	0.0006941729997453468	0.0006941729997453468	+1	ATM,BRCA1,BRCA2,ATR
SIGNALING BY FGFR4%REACTOME%R-HSA-5654743.4	Signaling by FGFR4	0.0006941729997453468	0.0006941729997453468	+1	PIK3CA,BRAF,PPP2R1A,PTPN11
VASCULOGENESIS%GOBP%GO:0001570	vasculogenesis	0.0006941729997453468	0.0006941729997453468	+1	NOTCH1,WT1,TGFBR2,SOX17
REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE/THREONINE KINASE SIGNALING PATHWAY%GOBP%GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.0006981335741075008	0.0006981335741075008	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021	FGF signaling pathway	0.0007089187691279237	0.0007089187691279237	+1	PIK3CA,MAP2K4,PIK3CG,FGFR2,FGFR3
POSITIVE REGULATION OF PROTEASOMAL UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0007089187691279237	0.0007089187691279237	+1	KEAP1,CEBPA,LRRK2,TAF1,AXIN2
REGULATION OF PEPTIDYL-TYROSINE PHOSPHORYLATION%GOBP%GO:0050730	regulation of peptidyl-tyrosine phosphorylation	0.0007379426527897607	0.0007379426527897607	+1	TP53,EGFR,FBXW7,FLT3,KIT,FGFR3,PTPN11
REGULATION OF DNA REPAIR%GOBP%GO:0006282	regulation of DNA repair	0.0007379426527897607	0.0007379426527897607	+1	ARID1A,PBRM1,EGFR,BRCA1,POLQ,SETD2,ATR,AXIN2
REGULATION OF PROTEASOMAL UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0007385571201657091	0.0007385571201657091	+1	KEAP1,CEBPA,LRRK2,USP9X,TAF1,AXIN2
REGULATION OF DNA REPLICATION%GOBP%GO:0006275	regulation of DNA replication	0.0007385571201657091	0.0007385571201657091	+1	EGFR,CDKN1B,ATRX,CDKN1A,ATR,SMC3
PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY	PID_P73PATHWAY	0.0007519375547938452	0.0007519375547938452	+1	RB1,WT1,EP300,BRCA2,CDKN1A
FLT3 SIGNALING%REACTOME%R-HSA-9607240.8	FLT3 Signaling	0.0007563852059931015	0.0007563852059931015	+1	PIK3CA,FLT3,CDKN1B,PTPN11
E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION	E-cadherin signaling in the nascent adherens junction	0.0007563852059931015	0.0007563852059931015	+1	PIK3CA,CTNNB1,CDH1,CCND1
MAMMARY GLAND DEVELOPMENT%GOBP%GO:0030879	mammary gland development	0.0007563852059931015	0.0007563852059931015	+1	ARHGAP35,TBX3,ELF3,FGFR2
ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 81%9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	0.0007563852059931015	0.0007563852059931015	+1	RB1,CDKN1B,CCND1,CDKN1A
CELLULAR RESPONSE TO OXIDATIVE STRESS%GOBP%GO:0034599	cellular response to oxidative stress	0.0007816968214292002	0.0007816968214292002	+1	TP53,EGFR,KEAP1,NFE2L2,ATM,LRRK2,PDGFRA
ADIPOGENESIS%WIKIPATHWAYS_20240510%WP236%HOMO SAPIENS	Adipogenesis	0.0008030906129872937	0.0008030906129872937	+1	GATA3,RB1,CTNNB1,CEBPA,CDKN1A,NCOR1
CARDIAC LEFT VENTRICLE MORPHOGENESIS%GOBP%GO:0003214	cardiac left ventricle morphogenesis	0.0008273698889061473	0.0008273698889061473	+1	NOTCH1,SMAD4,TGFBR2
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.0008273698889061473	0.0008273698889061473	+1	TP53,CDKN1B,CDKN1A
SPRY REGULATION OF FGF SIGNALING%REACTOME%R-HSA-1295596.3	Spry regulation of FGF signaling	0.0008273698889061473	0.0008273698889061473	+1	BRAF,PPP2R1A,PTPN11
NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH%GOBP%GO:0048640	negative regulation of developmental growth	0.0008273698889061473	0.0008273698889061473	+1	PTEN,CDKN1B,FGFR3,CDKN1A
P53 SIGNALING PATHWAY%PATHWHIZ%PW064774	P53 Signaling Pathway	0.0008273698889061473	0.0008273698889061473	+1	RB1,CCND1,CDKN1A
EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS%GOBP%GO:0048704	embryonic skeletal system morphogenesis	0.0008273698889061473	0.0008273698889061473	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY	PID_HNF3B_PATHWAY	0.0008273698889061473	0.0008273698889061473	+1	NF1,CEBPA,FOXA1,FOXA2
REGULATION OF BINDING%GOBP%GO:0051098	regulation of binding	0.0008325380796712354	0.0008325380796712354	+1	GATA3,RB1,LRRK2,USP9X,CDKN1A,TAF1,NSD1,SMAD2
BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY	BIOCARTA_PTEN_PATHWAY	0.0009946116000491701	0.0009946116000491701	+1	PTEN,EGFR,CDKN1B
EMBRYONIC CRANIAL SKELETON MORPHOGENESIS%GOBP%GO:0048701	embryonic cranial skeleton morphogenesis	0.0009946116000491701	0.0009946116000491701	+1	PDGFRA,FGFR2,TGFBR2
NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY%GOBP%GO:0090090	negative regulation of canonical Wnt signaling pathway	0.0009946116000491701	0.0009946116000491701	+1	APC,STK11,SOX9,SMAD4,SOX17,AXIN2
CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4	CTNNB1 S45 mutants aren't phosphorylated	0.0009946116000491701	0.0009946116000491701	+1	APC,CTNNB1,PPP2R1A
REGULATION OF MESENCHYMAL CELL PROLIFERATION%GOBP%GO:0010464	regulation of mesenchymal cell proliferation	0.0009946116000491701	0.0009946116000491701	+1	SOX9,FGFR2,TGFBR2
CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 81%5358747	CTNNB1 S33 mutants aren't phosphorylated	0.0009946116000491701	0.0009946116000491701	+1	APC,CTNNB1,PPP2R1A
CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 81%5358749	CTNNB1 S37 mutants aren't phosphorylated	0.0009946116000491701	0.0009946116000491701	+1	APC,CTNNB1,PPP2R1A
CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 81%5358752	CTNNB1 T41 mutants aren't phosphorylated	0.0009946116000491701	0.0009946116000491701	+1	APC,CTNNB1,PPP2R1A
SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 81%5339716	Signaling by GSK3beta mutants	0.0009946116000491701	0.0009946116000491701	+1	APC,CTNNB1,PPP2R1A
RAS PROTEIN SIGNAL TRANSDUCTION%GOBP%GO:0007265	Ras protein signal transduction	0.0009946116000491701	0.0009946116000491701	+1	TP53,NF1,CDKN2A,RB1,CDKN1A
NEGATIVE REGULATION OF MYOBLAST DIFFERENTIATION%GOBP%GO:0045662	negative regulation of myoblast differentiation	0.0009946116000491701	0.0009946116000491701	+1	NOTCH1,TBX3,SOX9
CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS%GOBP%GO:0035924	cellular response to vascular endothelial growth factor stimulus	0.0009946116000491701	0.0009946116000491701	+1	PIK3CA,NOTCH1,PDGFRA,EGR3
SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME DATABASE ID RELEASE 81%4839743	Signaling by CTNNB1 phospho-site mutants	0.0009946116000491701	0.0009946116000491701	+1	APC,CTNNB1,PPP2R1A
PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY	PID_TGFBR_PATHWAY	0.0009946116000491701	0.0009946116000491701	+1	CTNNB1,SMAD4,TGFBR2,SMAD2
TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 81%8853884	Transcriptional Regulation by VENTX	0.0009946116000491701	0.0009946116000491701	+1	TP53,CDKN2A,CTNNB1,CCND1
POSITIVE REGULATION OF PEPTIDYL-TYROSINE PHOSPHORYLATION%GOBP%GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	0.00101144262595581	0.00101144262595581	+1	TP53,FBXW7,FLT3,KIT,FGFR3,PTPN11
RHYTHMIC PROCESS%GOBP%GO:0048511	rhythmic process	0.00101144262595581	0.00101144262595581	+1	TP53,PTEN,PDGFRA,EP300,EGR3,NCOR1
REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20240510%WP51%HOMO SAPIENS	Regulation of actin cytoskeleton	0.00101144262595581	0.00101144262595581	+1	EGFR,ARHGAP35,BRAF,PDGFRA,FGFR2,FGFR3
SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP	Signaling events mediated by TCPTP	0.001072828386123987	0.001072828386123987	+1	PIK3CA,EGFR,HGF,ATR
REGULATION OF CELL PROLIFERATION INVOLVED IN HEART VALVE MORPHOGENESIS%GOBP%GO:0003250	regulation of cell proliferation involved in heart valve morphogenesis	0.001072828386123987	0.001072828386123987	+1	NOTCH1,SMAD4
PROSTATE GLAND EPITHELIUM MORPHOGENESIS%GOBP%GO:0060740	prostate gland epithelium morphogenesis	0.001072828386123987	0.001072828386123987	+1	SOX9,FGFR2
SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4	SMAD2 3 MH2 Domain Mutants in Cancer	0.001072828386123987	0.001072828386123987	+1	SMAD4,SMAD2
E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS	E-cadherin signaling events	0.001072828386123987	0.001072828386123987	+1	CTNNB1,CDH1
SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 81%3311021	SMAD4 MH2 Domain Mutants in Cancer	0.001072828386123987	0.001072828386123987	+1	SMAD4,SMAD2
FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS	FOXA transcription factor networks	0.001072828386123987	0.001072828386123987	+1	FOXA1,FOXA2
LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 81%3304347	Loss of Function of SMAD4 in Cancer	0.001072828386123987	0.001072828386123987	+1	SMAD4,SMAD2
POSITIVE REGULATION OF ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0046638	positive regulation of alpha-beta T cell differentiation	0.001072828386123987	0.001072828386123987	+1	RUNX1,EP300,TGFBR2,CBFB
NEGATIVE REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS%GOBP%GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis	0.001072828386123987	0.001072828386123987	+1	NOTCH1,TBX3
RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 81%8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	0.001072828386123987	0.001072828386123987	+1	RUNX1,CBFB
REGULATION OF ANIMAL ORGAN MORPHOGENESIS%GOBP%GO:2000027	regulation of animal organ morphogenesis	0.001072828386123987	0.001072828386123987	+1	GATA3,SOX9,WT1,HGF
NEGATIVE REGULATION OF MAMMARY GLAND EPITHELIAL CELL PROLIFERATION%GOBP%GO:0033600	negative regulation of mammary gland epithelial cell proliferation	0.001072828386123987	0.001072828386123987	+1	GATA3,BRCA2
PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6	Presynaptic phase of homologous DNA pairing and strand exchange	0.001072828386123987	0.001072828386123987	+1	ATM,BRCA1,BRCA2,ATR
TRANSFORMING GROWTH FACTOR BETA RECEPTOR SUPERFAMILY SIGNALING PATHWAY%GOBP%GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	0.0010750488391888318	0.0010750488391888318	+1	SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
CARDIAC VENTRICLE DEVELOPMENT%GOBP%GO:0003231	cardiac ventricle development	0.0010773030003022996	0.0010773030003022996	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
NEGATIVE REGULATION OF CYTOSKELETON ORGANIZATION%GOBP%GO:0051494	negative regulation of cytoskeleton organization	0.0011203489207189188	0.0011203489207189188	+1	PIK3CA,APC,NAV3,NPM1,BRCA1,SMAD4
GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 81%180292	GAB1 signalosome	0.0011391948747846564	0.0011391948747846564	+1	PIK3CA,EGFR,PTPN11
NEGATIVE REGULATION OF AUTOPHAGY%GOBP%GO:0010507	negative regulation of autophagy	0.0011391948747846564	0.0011391948747846564	+1	PIK3CA,VHL,HGF,LRRK2,EP300
TP53 NETWORK%WIKIPATHWAYS_20240510%WP1742%HOMO SAPIENS	TP53 network	0.0011391948747846564	0.0011391948747846564	+1	CDKN2A,ATM,CDKN1A
G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7	G2 M DNA damage checkpoint	0.0011391948747846564	0.0011391948747846564	+1	TP53,ATM,BRCA1,CHEK2,ATR
DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 81%9675136	Diseases of DNA Double-Strand Break Repair	0.0011391948747846564	0.0011391948747846564	+1	ATM,BRCA1,BRCA2,ATR
PROTEIN LOCALIZATION TO CHROMOSOME, TELOMERIC REGION%GOBP%GO:0070198	protein localization to chromosome, telomeric region	0.0011391948747846564	0.0011391948747846564	+1	ATRX,BRCA2,ATR
REGULATION OF CELLULAR RESPONSE TO HEAT%GOBP%GO:1900034	regulation of cellular response to heat	0.0011391948747846564	0.0011391948747846564	+1	ATM,EP300,ATR
DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 81%9701190	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	0.0011391948747846564	0.0011391948747846564	+1	ATM,BRCA1,BRCA2,ATR
CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20240510%WP3874%HOMO SAPIENS	Canonical and non canonical TGF B signaling	0.0011391948747846564	0.0011391948747846564	+1	SMAD4,TGFBR2,SMAD2
HISTONE MODIFICATIONS%WIKIPATHWAYS_20240510%WP2369%HOMO SAPIENS	Histone modifications	0.0011391948747846564	0.0011391948747846564	+1	MLL2,SETBP1,SETD2,EZH2
KIDNEY MORPHOGENESIS%GOBP%GO:0060993	kidney morphogenesis	0.0011391948747846564	0.0011391948747846564	+1	GATA3,SOX9,WT1,LRRK2
SYMPATHETIC NERVOUS SYSTEM DEVELOPMENT%GOBP%GO:0048485	sympathetic nervous system development	0.0011391948747846564	0.0011391948747846564	+1	NF1,GATA3,CTNNB1
MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20240510%WP4872%HOMO SAPIENS	MAP3K1 role in promoting and blocking gonadal determination	0.0011391948747846564	0.0011391948747846564	+1	CTNNB1,SOX9,FGFR2
CARDIAC MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0048738	cardiac muscle tissue development	0.0011395176514120502	0.0011395176514120502	+1	NOTCH1,TBX3,WT1,PDGFRA,FGFR2,SMAD4
NUCLEOSOME ORGANIZATION%GOBP%GO:0034728	nucleosome organization	0.0011804510875656662	0.0011804510875656662	+1	ARID1A,NPM1,SOX9,ATRX,SETD2
STRIATED MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0014706	striated muscle tissue development	0.0011866966104917371	0.0011866966104917371	+1	NOTCH1,TBX3,WT1,PDGFRA,FGFR2,SMAD4
RESPONSE TO OXIDATIVE STRESS%GOBP%GO:0006979	response to oxidative stress	0.0012082023303322158	0.0012082023303322158	+1	TP53,EGFR,KEAP1,NFE2L2,ATM,LRRK2,PDGFRA,ERCC2
DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 81%3769402	Deactivation of the beta-catenin transactivating complex	0.0012100057111679335	0.0012100057111679335	+1	APC,CTNNB1,SOX9,SOX17
ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20240510%WP2873%HOMO SAPIENS	Aryl hydrocarbon receptor pathway	0.0012100057111679335	0.0012100057111679335	+1	EGFR,NFE2L2,CDKN1B,EP300
OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20240510%WP5373%HOMO SAPIENS	Osteoarthritic chondrocyte hypertrophy	0.0012100057111679335	0.0012100057111679335	+1	VHL,SOX9,FGFR2,FGFR3
PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY	PID_FANCONI_PATHWAY	0.0012100057111679335	0.0012100057111679335	+1	ATM,BRCA1,BRCA2,ATR
STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION	Stabilization and expansion of the E-cadherin adherens junction	0.0012100057111679335	0.0012100057111679335	+1	EGFR,CTNNB1,CDH1,HGF
RETT SYNDROME%WIKIPATHWAYS_20240510%WP4312%HOMO SAPIENS	Rett syndrome	0.0012100057111679335	0.0012100057111679335	+1	BRAF,SMC1A,TBL1XR1,NCOR1
PEPTIDYL-THREONINE PHOSPHORYLATION%GOBP%GO:0018107	peptidyl-threonine phosphorylation	0.0012100057111679335	0.0012100057111679335	+1	STK11,LRRK2,TAF1,ACVR1B
CHORDATE EMBRYONIC DEVELOPMENT%GOBP%GO:0043009	chordate embryonic development	0.0012162195060951592	0.0012162195060951592	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK	p73 transcription factor network	0.001227393081139159	0.001227393081139159	+1	RB1,WT1,EP300,BRCA2,CDKN1A
MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0060537	muscle tissue development	0.001297826278545457	0.001297826278545457	+1	NF1,NOTCH1,TBX3,WT1,PDGFRA,FGFR2,SMAD4
BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.3	Beta-catenin phosphorylation cascade	0.0013097779822430597	0.0013097779822430597	+1	APC,CTNNB1,PPP2R1A
EMBRYONIC PATTERN SPECIFICATION%GOBP%GO:0009880	embryonic pattern specification	0.0013097779822430597	0.0013097779822430597	+1	TBX3,WT1,FGFR2,SMAD2
NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP61%HOMO SAPIENS	Notch signaling pathway	0.0013097779822430597	0.0013097779822430597	+1	NOTCH1,FBXW7,EP300,NCOR1
METANEPHRIC NEPHRON DEVELOPMENT%GOBP%GO:0072210	metanephric nephron development	0.0013097779822430597	0.0013097779822430597	+1	SOX9,WT1,PDGFRA
CELL SURFACE RECEPTOR PROTEIN SERINE/THREONINE KINASE SIGNALING PATHWAY%GOBP%GO:0007178	cell surface receptor protein serine/threonine kinase signaling pathway	0.0013097779822430597	0.0013097779822430597	+1	SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20240510%WP4300%HOMO SAPIENS	Extracellular vesicles in the crosstalk of cardiac cells	0.0013097779822430597	0.0013097779822430597	+1	PTEN,EGFR,TLR4
CELLULAR RESPONSE TO GAMMA RADIATION%GOBP%GO:0071480	cellular response to gamma radiation	0.0013097779822430597	0.0013097779822430597	+1	TP53,ATM,ATR
SIGNALING BY FGFR1%REACTOME%R-HSA-5654736.6	Signaling by FGFR1	0.0013097779822430597	0.0013097779822430597	+1	PIK3CA,BRAF,PPP2R1A,PTPN11
PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 81%9754189	Primitive streak formation	0.0013097779822430597	0.0013097779822430597	+1	CTNNB1,SMAD4,SMAD2
PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY	PID_ECADHERIN_KERATINOCYTE_PATHWAY	0.0013097779822430597	0.0013097779822430597	+1	EGFR,CTNNB1,AJUBA
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693579.5	Homologous DNA Pairing and Strand Exchange	0.0013097779822430597	0.0013097779822430597	+1	ATM,BRCA1,BRCA2,ATR
IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20240510%WP3640%HOMO SAPIENS	Imatinib and chronic myeloid leukemia	0.0013097779822430597	0.0013097779822430597	+1	CDKN1B,KIT,PDGFRA
NEGATIVE REGULATION OF SMALL MOLECULE METABOLIC PROCESS%GOBP%GO:0062014	negative regulation of small molecule metabolic process	0.001345235583195276	0.001345235583195276	+1	TP53,SOX9,BRCA1,EP300,NCOR1
HALLMARK_P53_PATHWAY%MSIGDBHALLMARK%HALLMARK_P53_PATHWAY	HALLMARK_P53_PATHWAY	0.0013526702485191528	0.0013526702485191528	+1	CDKN2A,RB1,NOTCH1,FBXW7,CEBPA,CDKN1A,ACVR1B
FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS	FOXA2 and FOXA3 transcription factor networks	0.0014019097524844777	0.0014019097524844777	+1	NF1,CEBPA,FOXA1,FOXA2
STEM CELL POPULATION MAINTENANCE%GOBP%GO:0019827	stem cell population maintenance	0.0014019097524844777	0.0014019097524844777	+1	NOTCH1,CTNNB1,SOX9,KIT
SIGNALING BY NTRKS%REACTOME%R-HSA-166520.6	Signaling by NTRKs	0.0014543341231623298	0.0014543341231623298	+1	PIK3CA,BRAF,EP300,PPP2R1A,PTPN11,EGR3
NEGATIVE REGULATION OF MAPK CASCADE%GOBP%GO:0043409	negative regulation of MAPK cascade	0.0014543341231623298	0.0014543341231623298	+1	NF1,TLR4,SMAD4,MAPK8IP1,MECOM,NCOR1
SMALL CELL LUNG CANCER%WIKIPATHWAYS_20240510%WP4658%HOMO SAPIENS	Small cell lung cancer	0.0014897120985134422	0.0014897120985134422	+1	PTEN,RB1,CDKN1B,CCND1,CDKN1A
LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20240510%WP4258%HOMO SAPIENS	lncRNA in canonical Wnt signaling and colorectal cancer	0.0014897120985134422	0.0014897120985134422	+1	CTNNB1,CCND1,SOX17,AXIN2,EZH2
PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY	PID_AR_PATHWAY	0.0015143072907848453	0.0015143072907848453	+1	CDKN2A,CTNNB1,BRCA1,CCND1
MAINTENANCE OF CELL NUMBER%GOBP%GO:0098727	maintenance of cell number	0.0015143072907848453	0.0015143072907848453	+1	NOTCH1,CTNNB1,SOX9,KIT
NEGATIVE REGULATION OF VASCULAR ASSOCIATED SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	0.0015244647251836333	0.0015244647251836333	+1	PTEN,CDKN1B,CDKN1A
DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN	Degradation of beta catenin	0.0015244647251836333	0.0015244647251836333	+1	APC,CTNNB1,AXIN2
FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 81%9830364	Formation of the nephric duct	0.0015244647251836333	0.0015244647251836333	+1	GATA3,CTNNB1,MECOM
SECONDARY PALATE DEVELOPMENT%GOBP%GO:0062009	secondary palate development	0.0015244647251836333	0.0015244647251836333	+1	SMAD4,TGFBR2,SMAD2
CARDIAC CHAMBER MORPHOGENESIS%GOBP%GO:0003206	cardiac chamber morphogenesis	0.0015559595361129843	0.0015559595361129843	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
TRANSCRIPTION INITIATION AT RNA POLYMERASE II PROMOTER%GOBP%GO:0006367	transcription initiation at RNA polymerase II promoter	0.0016167891442408703	0.0016167891442408703	+1	TP53,ARID1A,TET2,EP300,TAF1,ERCC2
PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING	Presenilin action in Notch and Wnt signaling	0.0016177217176071897	0.0016177217176071897	+1	APC,NOTCH1,CTNNB1,CCND1
KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 81%9830369	Kidney development	0.0016177217176071897	0.0016177217176071897	+1	GATA3,CTNNB1,WT1,MECOM
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.5	NOTCH1 Intracellular Domain Regulates Transcription	0.0016177217176071897	0.0016177217176071897	+1	NOTCH1,EP300,TBL1XR1,NCOR1
PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.5	PKMTs methylate histone lysines	0.0016177217176071897	0.0016177217176071897	+1	SETD2,NSD1,MECOM,EZH2
PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY	PID_FGF_PATHWAY	0.0016177217176071897	0.0016177217176071897	+1	HGF,FGFR2,FGFR3,PTPN11
HALLMARK_APOPTOSIS%MSIGDBHALLMARK%HALLMARK_APOPTOSIS	HALLMARK_APOPTOSIS	0.001665768436259484	0.001665768436259484	+1	CTNNB1,CDKN1B,HGF,BRCA1,CCND1,CDKN1A
POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION%GOBP%GO:1901989	positive regulation of cell cycle phase transition	0.001709703714373045	0.001709703714373045	+1	EGFR,RB1,NPM1,CCND1,EZH2
REGULATION OF ALPHA-BETA T CELL ACTIVATION%GOBP%GO:0046634	regulation of alpha-beta T cell activation	0.001709703714373045	0.001709703714373045	+1	RUNX1,EP300,TGFBR2,CBFB,MAPK8IP1
NEGATIVE REGULATION OF GENE EXPRESSION, EPIGENETIC%GOBP%GO:0045814	negative regulation of gene expression, epigenetic	0.0017250619230517635	0.0017250619230517635	+1	RB1,DNMT3A,WT1,ATRX,BRCA1,EZH2
FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY	Fanconi anemia pathway	0.0017345955086946016	0.0017345955086946016	+1	ATM,BRCA1,BRCA2,ATR
BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE%GOBP%GO:0048754	branching morphogenesis of an epithelial tube	0.0017345955086946016	0.0017345955086946016	+1	CTNNB1,WT1,FGFR2,TGFBR2
RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4	RMTs methylate histone arginines	0.0017345955086946016	0.0017345955086946016	+1	ARID1A,PBRM1,DNMT3A,CCND1
MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20240510%WP4205%HOMO SAPIENS	MET in type 1 papillary renal cell carcinoma	0.0017345955086946016	0.0017345955086946016	+1	BRAF,HGF,CDKN1A,PTPN11
REGULATION OF CELL-CELL ADHESION MEDIATED BY CADHERIN%GOBP%GO:2000047	regulation of cell-cell adhesion mediated by cadherin	0.0017445723330160234	0.0017445723330160234	+1	NOTCH1,FOXA1,FOXA2
HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0017445723330160234	0.0017445723330160234	+1	TP53,VHL,CDKN2A
GENITALIA DEVELOPMENT%GOBP%GO:0048806	genitalia development	0.0017445723330160234	0.0017445723330160234	+1	TBX3,WT1,PTPN11
RESPONSE TO ALCOHOL%GOBP%GO:0097305	response to alcohol	0.0017668389097793818	0.0017668389097793818	+1	CTNNB1,CDH1,BRCA1,TGFBR2,SMAD2
REGULATION OF G2/M TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:0010389	regulation of G2/M transition of mitotic cell cycle	0.0017668389097793818	0.0017668389097793818	+1	ATM,BRCA1,CCND1,CDKN1A,ATR
SMALL GTPASE-MEDIATED SIGNAL TRANSDUCTION%GOBP%GO:0007264	small GTPase-mediated signal transduction	0.0017668389097793818	0.0017668389097793818	+1	TP53,NF1,CDKN2A,RB1,ARHGAP35,LRRK2,CDKN1A
REGULATION OF MITOTIC METAPHASE/ANAPHASE TRANSITION%GOBP%GO:0030071	regulation of mitotic metaphase/anaphase transition	0.0017668389097793818	0.0017668389097793818	+1	APC,ARID1A,PBRM1,RB1,ATM
PROSTATE GLAND MORPHOGENESIS%GOBP%GO:0060512	prostate gland morphogenesis	0.0017934306061719678	0.0017934306061719678	+1	SOX9,FGFR2
REPLICATION OF THE SARS-COV-1 GENOME%REACTOME DATABASE ID RELEASE 81%9682706	Replication of the SARS-CoV-1 genome	0.0017934306061719678	0.0017934306061719678	+1	VHL,RB1
EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING%GOBP%GO:0009792	embryo development ending in birth or egg hatching	0.0017934306061719678	0.0017934306061719678	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7	Replication of the SARS-CoV-2 genome	0.0017934306061719678	0.0017934306061719678	+1	VHL,RB1
BRANCH ELONGATION OF AN EPITHELIUM%GOBP%GO:0060602	branch elongation of an epithelium	0.0017934306061719678	0.0017934306061719678	+1	SOX9,FGFR2
OTIC VESICLE FORMATION%GOBP%GO:0030916	otic vesicle formation	0.0017934306061719678	0.0017934306061719678	+1	SOX9,FGFR2
SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4	SARS-CoV-2 Genome Replication and Transcription	0.0017934306061719678	0.0017934306061719678	+1	VHL,RB1
TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4	Transcriptional activation of p53 responsive genes	0.0017934306061719678	0.0017934306061719678	+1	TP53,CDKN1A
FOREBRAIN MORPHOGENESIS%GOBP%GO:0048853	forebrain morphogenesis	0.0017934306061719678	0.0017934306061719678	+1	PTEN,NF1
PROSTATE GLAND GROWTH%GOBP%GO:0060736	prostate gland growth	0.0017934306061719678	0.0017934306061719678	+1	SOX9,FGFR2
HOMEOSTASIS OF NUMBER OF CELLS WITHIN A TISSUE%GOBP%GO:0048873	homeostasis of number of cells within a tissue	0.0017934306061719678	0.0017934306061719678	+1	NOTCH1,SOX9
SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME DATABASE ID RELEASE 81%9679514	SARS-CoV-1 Genome Replication and Transcription	0.0017934306061719678	0.0017934306061719678	+1	VHL,RB1
MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 81%8865999	MET activates PTPN11	0.0017934306061719678	0.0017934306061719678	+1	HGF,PTPN11
INTESTINAL EPITHELIAL STRUCTURE MAINTENANCE%GOBP%GO:0060729	intestinal epithelial structure maintenance	0.0017934306061719678	0.0017934306061719678	+1	SOX9,TLR4
OTIC VESICLE MORPHOGENESIS%GOBP%GO:0071600	otic vesicle morphogenesis	0.0017934306061719678	0.0017934306061719678	+1	SOX9,FGFR2
TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5	Transcriptional activation of cell cycle inhibitor p21	0.0017934306061719678	0.0017934306061719678	+1	TP53,CDKN1A
NEGATIVE REGULATION OF COLD-INDUCED THERMOGENESIS%GOBP%GO:0120163	negative regulation of cold-induced thermogenesis	0.001802921830282145	0.001802921830282145	+1	RB1,NOTCH1,STK11,TLR4
MITOTIC SPINDLE ASSEMBLY%GOBP%GO:0090307	mitotic spindle assembly	0.001802921830282145	0.001802921830282145	+1	STAG2,CHEK2,SMC1A,SMC3
OSSIFICATION%GOBP%GO:0001503	ossification	0.0018440563471340521	0.0018440563471340521	+1	EGFR,NF1,CTNNB1,RUNX1,FGFR2,FGFR3
OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.7	Oxidative Stress Induced Senescence	0.00188868302624034	0.00188868302624034	+1	TP53,CDKN2A,MAP2K4,CDKN2C,EZH2
REGULATION OF METAPHASE/ANAPHASE TRANSITION OF CELL CYCLE%GOBP%GO:1902099	regulation of metaphase/anaphase transition of cell cycle	0.00188868302624034	0.00188868302624034	+1	APC,ARID1A,PBRM1,RB1,ATM
SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 81%9700206	Signaling by ALK in cancer	0.00188868302624034	0.00188868302624034	+1	TP53,PIK3CA,RB1,NPM1,CDKN1A
SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME DATABASE ID RELEASE 81%9725370	Signaling by ALK fusions and activated point mutants	0.00188868302624034	0.00188868302624034	+1	TP53,PIK3CA,RB1,NPM1,CDKN1A
REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2001185	regulation of CD8-positive, alpha-beta T cell activation	0.0019302651199409211	0.0019302651199409211	+1	RUNX1,CBFB,MAPK8IP1
POSITIVE REGULATION OF HEART GROWTH%GOBP%GO:0060421	positive regulation of heart growth	0.0019302651199409211	0.0019302651199409211	+1	NOTCH1,WT1,FGFR2
CARDIAC SEPTUM MORPHOGENESIS%GOBP%GO:0060411	cardiac septum morphogenesis	0.0019302651199409211	0.0019302651199409211	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GLAND MORPHOGENESIS%GOBP%GO:0022612	gland morphogenesis	0.0019302651199409211	0.0019302651199409211	+1	SOX9,ELF3,FGFR2
POSITIVE REGULATION OF ORGAN GROWTH%GOBP%GO:0046622	positive regulation of organ growth	0.0019302651199409211	0.0019302651199409211	+1	NOTCH1,WT1,FGFR2
MITOTIC G2/M TRANSITION CHECKPOINT%GOBP%GO:0044818	mitotic G2/M transition checkpoint	0.0019302651199409211	0.0019302651199409211	+1	ATM,BRCA1,CDKN1A,ATR
SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8	SARS-CoV-1 Infection	0.0019500213191697687	0.0019500213191697687	+1	VHL,RB1,NPM1,RUNX1,EP300,SMAD4
SPINDLE ORGANIZATION%GOBP%GO:0007051	spindle organization	0.0019500213191697687	0.0019500213191697687	+1	PTEN,STAG2,CHEK2,SMC1A,SMC3,NCOR1
CELLULAR RESPONSE TO INORGANIC SUBSTANCE%GOBP%GO:0071241	cellular response to inorganic substance	0.0019500213191697687	0.0019500213191697687	+1	EGFR,CDH1,BRAF,CDKN1B,ATRX,LRRK2
DISEASES OF DNA REPAIR%REACTOME%R-HSA-9675135.6	Diseases of DNA repair	0.0020538024771829372	0.0020538024771829372	+1	ATM,BRCA1,BRCA2,ATR
MYELOID LEUKOCYTE DIFFERENTIATION%GOBP%GO:0002573	myeloid leukocyte differentiation	0.0020538024771829372	0.0020538024771829372	+1	GATA3,RUNX1,CEBPA,KIT,TGFBR2
EMBRYONIC SKELETAL SYSTEM DEVELOPMENT%GOBP%GO:0048706	embryonic skeletal system development	0.0020538024771829372	0.0020538024771829372	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3	TCF dependent signaling in response to WNT	0.0020611637311217204	0.0020611637311217204	+1	APC,CTNNB1,SOX9,EP300,SOX17,PPP2R1A,AXIN2
REGULATION OF TOR SIGNALING%GOBP%GO:0032006	regulation of TOR signaling	0.0020876254048426196	0.0020876254048426196	+1	PIK3CA,VHL,STK11,ATM,EP300,USP9X
REGULATION OF OSTEOBLAST DIFFERENTIATION%GOBP%GO:0045667	regulation of osteoblast differentiation	0.0021463399409048364	0.0021463399409048364	+1	NOTCH1,SOX9,HGF,FGFR2,ACVR2A
HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20240510%WP5426%HOMO SAPIENS	HDAC6 interactions in the central nervous system	0.0021463399409048364	0.0021463399409048364	+1	VHL,EGFR,CTNNB1,EP300,SMAD2
TRANSCRIPTION INITIATION-COUPLED CHROMATIN REMODELING%GOBP%GO:0045815	transcription initiation-coupled chromatin remodeling	0.0021867777520713865	0.0021867777520713865	+1	TP53,ARID1A,TET2,EP300
REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION%GOBP%GO:0060043	regulation of cardiac muscle cell proliferation	0.0021867777520713865	0.0021867777520713865	+1	NOTCH1,RUNX1,FGFR2
BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY	BIOCARTA_NTHI_PATHWAY	0.0021867777520713865	0.0021867777520713865	+1	EP300,SMAD4,TGFBR2
PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY	PID_ALK1_PATHWAY	0.0021867777520713865	0.0021867777520713865	+1	SMAD4,TGFBR2,ACVR2A
REGULATION OF CARDIOCYTE DIFFERENTIATION%GOBP%GO:1905207	regulation of cardiocyte differentiation	0.0021867777520713865	0.0021867777520713865	+1	EGFR,SMAD4,SOX17
CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES%GOBP%GO:0034614	cellular response to reactive oxygen species	0.002234926322121837	0.002234926322121837	+1	EGFR,NFE2L2,ATM,LRRK2,PDGFRA
DOUBLE-STRAND BREAK REPAIR%GOBP%GO:0006302	double-strand break repair	0.0022864201222512304	0.0022864201222512304	+1	ATM,BRCA1,POLQ,CHEK2,BRCA2,ATR,RAD21
G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:0000082	G1/S transition of mitotic cell cycle	0.002329295811442061	0.002329295811442061	+1	CDKN1B,CCND1,CDKN1A,ACVR1B
TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING	TGF-beta receptor signaling	0.002329295811442061	0.002329295811442061	+1	CTNNB1,SMAD4,TGFBR2,SMAD2
PEPTIDYL-THREONINE MODIFICATION%GOBP%GO:0018210	peptidyl-threonine modification	0.002329295811442061	0.002329295811442061	+1	STK11,LRRK2,TAF1,ACVR1B
SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)	Signaling events mediated by Stem cell factor receptor (c-Kit)	0.002329295811442061	0.002329295811442061	+1	PIK3CA,PTEN,KIT,PTPN11
PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY	PID_FAK_PATHWAY	0.002329295811442061	0.002329295811442061	+1	ARHGAP35,MAP2K4,BRAF,CCND1
REGULATION OF EPITHELIAL CELL MIGRATION%GOBP%GO:0010632	regulation of epithelial cell migration	0.002401967888836679	0.002401967888836679	+1	PTEN,NF1,GATA3,NOTCH1,EPPK1,PIK3CG,SOX9
NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 81%9759194	Nuclear events mediated by NFE2L2	0.0024351140468371448	0.0024351140468371448	+1	CDKN2A,NOTCH1,KEAP1,NFE2L2,EP300
NEGATIVE REGULATION OF WNT SIGNALING PATHWAY%GOBP%GO:0030178	negative regulation of Wnt signaling pathway	0.002445438014810711	0.002445438014810711	+1	APC,STK11,SOX9,SMAD4,SOX17,AXIN2
CELLULAR RESPONSE TO BMP STIMULUS%GOBP%GO:0071773	cellular response to BMP stimulus	0.0024480263295168017	0.0024480263295168017	+1	SOX9,SMAD4,USP9X,ACVR2A
BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY	BIOCARTA_WNT_PATHWAY	0.0024480263295168017	0.0024480263295168017	+1	CTNNB1,CCND1,SMAD4
GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20240510%WP4830%HOMO SAPIENS	GDNF RET signaling axis	0.0024480263295168017	0.0024480263295168017	+1	GATA3,CTNNB1,SOX17
MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20240510%WP3982%HOMO SAPIENS	miRNA regulation of p53 pathway in prostate cancer	0.0024480263295168017	0.0024480263295168017	+1	PTEN,ATM,CHEK2
BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY	BIOCARTA_VDR_PATHWAY	0.0024480263295168017	0.0024480263295168017	+1	ARID1A,EP300,NCOR1
REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY	Regulation of Androgen receptor activity	0.0024480263295168017	0.0024480263295168017	+1	MAP2K4,CEBPA,AR,EP300
RESPONSE TO BMP%GOBP%GO:0071772	response to BMP	0.0024480263295168017	0.0024480263295168017	+1	SOX9,SMAD4,USP9X,ACVR2A
POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS%GOBP%GO:2000379	positive regulation of reactive oxygen species metabolic process	0.0024480263295168017	0.0024480263295168017	+1	TP53,TLR4,TGFBR2,CDKN1A
DIGESTIVE TRACT MORPHOGENESIS%GOBP%GO:0048546	digestive tract morphogenesis	0.0024480263295168017	0.0024480263295168017	+1	PDGFRA,FGFR2,SOX17
RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795	Rac 1 Cell Motility Signaling Pathway	0.0024480263295168017	0.0024480263295168017	+1	PDGFRA,CCND1,CDKN1A
REGULATION OF TELOMERE MAINTENANCE VIA TELOMERASE%GOBP%GO:0032210	regulation of telomere maintenance via telomerase	0.0024480263295168017	0.0024480263295168017	+1	TP53,CTNNB1,ATM,ATR
POSITIVE REGULATION OF GENE EXPRESSION, EPIGENETIC%GOBP%GO:0141137	positive regulation of gene expression, epigenetic	0.0024480263295168017	0.0024480263295168017	+1	TP53,ARID1A,TET2,EP300
NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS%GOBP%GO:0031330	negative regulation of cellular catabolic process	0.0024998408699372578	0.0024998408699372578	+1	PIK3CA,VHL,HGF,LRRK2,EP300
CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:0044843	cell cycle G1/S phase transition	0.002614608989030048	0.002614608989030048	+1	CDKN1B,CCND1,CDKN1A,ACVR1B
DNA REPAIR PATHWAYS FULL NETWORK%WIKIPATHWAYS_20240510%WP4946%HOMO SAPIENS	DNA repair pathways full network	0.002614608989030048	0.002614608989030048	+1	ATM,BRCA1,BRCA2,ATR,ERCC2
POSITIVE REGULATION OF ALPHA-BETA T CELL ACTIVATION%GOBP%GO:0046635	positive regulation of alpha-beta T cell activation	0.002614608989030048	0.002614608989030048	+1	RUNX1,EP300,TGFBR2,CBFB
NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 81%9818035	NFE2L2 regulating ER-stress associated genes	0.0026585660374313174	0.0026585660374313174	+1	NFE2L2,EP300
LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 81%3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.0026585660374313174	0.0026585660374313174	+1	CTNNB1,EP300
CELLULAR RESPONSE TO LITHIUM ION%GOBP%GO:0071285	cellular response to lithium ion	0.0026585660374313174	0.0026585660374313174	+1	CDH1,CDKN1B
MET ACTIVATES PI3K AKT SIGNALING%REACTOME%R-HSA-8851907.2	MET activates PI3K AKT signaling	0.0026585660374313174	0.0026585660374313174	+1	PIK3CA,HGF
MEMBRANOUS SEPTUM MORPHOGENESIS%GOBP%GO:0003149	membranous septum morphogenesis	0.0026585660374313174	0.0026585660374313174	+1	FGFR2,TGFBR2
ENDOCARDIUM MORPHOGENESIS%GOBP%GO:0003160	endocardium morphogenesis	0.0026585660374313174	0.0026585660374313174	+1	NOTCH1,SOX17
POSITIVE REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	0.0026585660374313174	0.0026585660374313174	+1	RUNX1,CBFB
DETERMINATION OF ADULT LIFESPAN%GOBP%GO:0008340	determination of adult lifespan	0.0026585660374313174	0.0026585660374313174	+1	TP53,LRRK2
NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1	NFE2L2 regulating inflammation associated genes	0.0026585660374313174	0.0026585660374313174	+1	NFE2L2,EP300
RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME%R-HSA-8935964.2	RUNX1 regulates expression of components of tight junctions	0.0026585660374313174	0.0026585660374313174	+1	RUNX1,CBFB
TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 81%3656532	TGFBR1 KD Mutants in Cancer	0.0026585660374313174	0.0026585660374313174	+1	TGFBR2,SMAD2
PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS	PLK3 signaling events	0.0026585660374313174	0.0026585660374313174	+1	TP53,CHEK2
SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 81%3304356	SMAD2 3 Phosphorylation Motif Mutants in Cancer	0.0026585660374313174	0.0026585660374313174	+1	TGFBR2,SMAD2
MALE GENITALIA DEVELOPMENT%GOBP%GO:0030539	male genitalia development	0.0026585660374313174	0.0026585660374313174	+1	TBX3,WT1
POSITIVE REGULATION OF ACTIVIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0032927	positive regulation of activin receptor signaling pathway	0.0026585660374313174	0.0026585660374313174	+1	ACVR1B,ACVR2A
NEGATIVE REGULATION OF CELL PROLIFERATION INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:1901723	negative regulation of cell proliferation involved in kidney development	0.0026585660374313174	0.0026585660374313174	+1	GATA3,WT1
FRAGILE X SYNDROME%WIKIPATHWAYS_20240510%WP4549%HOMO SAPIENS	Fragile X syndrome	0.0026619002306020683	0.0026619002306020683	+1	PTEN,NF1,CDKN2A,BRAF,PTPN11
CARDIAC CHAMBER DEVELOPMENT%GOBP%GO:0003205	cardiac chamber development	0.0026619002306020683	0.0026619002306020683	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
RESPONSE TO GAMMA RADIATION%GOBP%GO:0010332	response to gamma radiation	0.002671628368245708	0.002671628368245708	+1	TP53,ATM,ATR
NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-HSA-5654732.3	Negative regulation of FGFR3 signaling	0.002671628368245708	0.002671628368245708	+1	BRAF,PPP2R1A,PTPN11
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 81%8940973	RUNX2 regulates osteoblast differentiation	0.002671628368245708	0.002671628368245708	+1	RB1,AR,CBFB
ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20240510%WP5036%HOMO SAPIENS	Angiotensin II receptor type 1 pathway	0.002671628368245708	0.002671628368245708	+1	SMAD4,TGFBR2,PTPN11
ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	0.002671628368245708	0.002671628368245708	+1	EGFR,CDKN1B,CCND1
POSITIVE REGULATION OF CELL CYCLE PROCESS%GOBP%GO:0090068	positive regulation of cell cycle process	0.002674746551515877	0.002674746551515877	+1	EGFR,RB1,NPM1,ATRX,CCND1,RAD21,EZH2
CIRCADIAN RHYTHM%GOBP%GO:0007623	circadian rhythm	0.002760114427143925	0.002760114427143925	+1	TP53,PTEN,EP300,EGR3,NCOR1
10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20240510%WP5402%HOMO SAPIENS	10q22q23 copy number variation	0.0028724193819998113	0.0028724193819998113	+1	CEBPA,SMC1A,SMC3,RAD21
TUBE FORMATION%GOBP%GO:0035148	tube formation	0.0028724193819998113	0.0028724193819998113	+1	GATA3,NOTCH1,SOX9,FGFR2
CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS%GOBP%GO:0071560	cellular response to transforming growth factor beta stimulus	0.0028724193819998113	0.0028724193819998113	+1	SOX9,SMAD4,USP9X,TGFBR2,SMAD2
REGULATION OF SISTER CHROMATID SEGREGATION%GOBP%GO:0033045	regulation of sister chromatid segregation	0.0028724193819998113	0.0028724193819998113	+1	APC,ARID1A,PBRM1,RB1,ATM
REGULATION OF ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0046637	regulation of alpha-beta T cell differentiation	0.0028724193819998113	0.0028724193819998113	+1	RUNX1,EP300,TGFBR2,CBFB
REGULATION OF ORGANELLE ASSEMBLY%GOBP%GO:1902115	regulation of organelle assembly	0.0028796686177998258	0.0028796686177998258	+1	ARHGAP35,NPM1,ATM,BRCA1,LRRK2,CHEK2,SMAD4
HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20240510%WP3668%HOMO SAPIENS	Hypothesized pathways in pathogenesis of cardiovascular disease	0.002989597554363992	0.002989597554363992	+1	SMAD4,TGFBR2,SMAD2
BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY	BIOCARTA_CARM_ER_PATHWAY	0.002989597554363992	0.002989597554363992	+1	BRCA1,EP300,CCND1
IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 81%9709603	Impaired BRCA2 binding to PALB2	0.002989597554363992	0.002989597554363992	+1	ATM,BRCA1,BRCA2
DIGESTIVE TRACT DEVELOPMENT%GOBP%GO:0048565	digestive tract development	0.0030156691793257885	0.0030156691793257885	+1	KIT,PDGFRA,FGFR2,SOX17
CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 81%2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.0030156691793257885	0.0030156691793257885	+1	NOTCH1,EP300,TBL1XR1,NCOR1
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 81%2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.0030156691793257885	0.0030156691793257885	+1	NOTCH1,EP300,TBL1XR1,NCOR1
CELLULAR RESPONSE TO FIBROBLAST GROWTH FACTOR STIMULUS%GOBP%GO:0044344	cellular response to fibroblast growth factor stimulus	0.0030156691793257885	0.0030156691793257885	+1	FGFR2,FGFR3,PTPN11,EGR3
TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 81%8986944	Transcriptional Regulation by MECP2	0.0030156691793257885	0.0030156691793257885	+1	PTEN,SIN3A,TBL1XR1,NCOR1
CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 81%2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.0030156691793257885	0.0030156691793257885	+1	NOTCH1,EP300,TBL1XR1,NCOR1
SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 81%2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.0030156691793257885	0.0030156691793257885	+1	NOTCH1,EP300,TBL1XR1,NCOR1
STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 81%69541	Stabilization of p53	0.0030156691793257885	0.0030156691793257885	+1	TP53,CDKN2A,ATM,CHEK2
SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 81%2644603	Signaling by NOTCH1 in Cancer	0.0030156691793257885	0.0030156691793257885	+1	NOTCH1,EP300,TBL1XR1,NCOR1
DNA-TEMPLATED TRANSCRIPTION INITIATION%GOBP%GO:0006352	DNA-templated transcription initiation	0.0030619525348065755	0.0030619525348065755	+1	TP53,ARID1A,TET2,EP300,TAF1,ERCC2
WNT SIGNALING PATHWAY%GOBP%GO:0016055	Wnt signaling pathway	0.0030693971718202028	0.0030693971718202028	+1	PTEN,GATA3,CTNNB1,LRRK2,AXIN2
REGULATION OF TELOMERE MAINTENANCE%GOBP%GO:0032204	regulation of telomere maintenance	0.0030693971718202028	0.0030693971718202028	+1	TP53,CTNNB1,ATM,ATRX,ATR
AXIS SPECIFICATION%GOBP%GO:0009798	axis specification	0.003195935731612769	0.003195935731612769	+1	TBX3,WT1,FOXA2,SMAD2
SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING	SHP2 signaling	0.003195935731612769	0.003195935731612769	+1	PIK3CA,EGFR,ARHGAP35,PTPN11
ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING	ErbB1 downstream signaling	0.003195935731612769	0.003195935731612769	+1	PIK3CA,EGFR,MAP2K4,BRAF,PPP2R1A
REGULATION OF CARDIAC MUSCLE TISSUE GROWTH%GOBP%GO:0055021	regulation of cardiac muscle tissue growth	0.0032512430466509526	0.0032512430466509526	+1	NOTCH1,RUNX1,FGFR2
REGULATION OF KIDNEY DEVELOPMENT%GOBP%GO:0090183	regulation of kidney development	0.0032512430466509526	0.0032512430466509526	+1	GATA3,SOX9,WT1
POSITIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY%GOBP%GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	0.0032512430466509526	0.0032512430466509526	+1	STK11,EP300,SMAD4
POSITIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS%GOBP%GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus	0.0032512430466509526	0.0032512430466509526	+1	STK11,EP300,SMAD4
KLEEFSTRA SYNDROME%WIKIPATHWAYS_20240510%WP5351%HOMO SAPIENS	Kleefstra syndrome	0.0032512430466509526	0.0032512430466509526	+1	ARID1A,BAP1,ASXL1
REGULATION OF NEUROBLAST PROLIFERATION%GOBP%GO:1902692	regulation of neuroblast proliferation	0.0032512430466509526	0.0032512430466509526	+1	NF1,CTNNB1,LRRK2
POSITIVE REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION%GOBP%GO:1903055	positive regulation of extracellular matrix organization	0.0032512430466509526	0.0032512430466509526	+1	RB1,RUNX1,SMAD4
DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME DATABASE ID RELEASE 81%9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function	0.0032512430466509526	0.0032512430466509526	+1	ATM,BRCA1,BRCA2
DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 81%9701192	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	0.0032512430466509526	0.0032512430466509526	+1	ATM,BRCA1,BRCA2
OUTFLOW TRACT SEPTUM MORPHOGENESIS%GOBP%GO:0003148	outflow tract septum morphogenesis	0.0032512430466509526	0.0032512430466509526	+1	FGFR2,SMAD4,TGFBR2
DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	0.0032512430466509526	0.0032512430466509526	+1	ATM,BRCA1,BRCA2
DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 81%9701193	Defective homologous recombination repair (HRR) due to PALB2 loss of function	0.0032512430466509526	0.0032512430466509526	+1	ATM,BRCA1,BRCA2
RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2500257.5	Resolution of Sister Chromatid Cohesion	0.003278676107616236	0.003278676107616236	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
RESPONSE TO FIBROBLAST GROWTH FACTOR%GOBP%GO:0071774	response to fibroblast growth factor	0.0033383173797993386	0.0033383173797993386	+1	FGFR2,FGFR3,PTPN11,EGR3
DIGESTIVE SYSTEM DEVELOPMENT%GOBP%GO:0055123	digestive system development	0.0033383173797993386	0.0033383173797993386	+1	KIT,PDGFRA,FGFR2,SOX17
BEHAVIOR%GOBP%GO:0007610	behavior	0.003408587937685355	0.003408587937685355	+1	TP53,PTEN,EGFR,NF1,LRRK2,FOXA2,NCOR1
POSITIVE REGULATION OF CHROMOSOME ORGANIZATION%GOBP%GO:2001252	positive regulation of chromosome organization	0.0035199459451595544	0.0035199459451595544	+1	CTNNB1,ATM,ATRX,ATR,RAD21
REGULATION OF SMOOTH MUSCLE CELL DIFFERENTIATION%GOBP%GO:0051150	regulation of smooth muscle cell differentiation	0.0035199459451595544	0.0035199459451595544	+1	NOTCH1,KIT,FGFR2
RESPONSE TO TRANSFORMING GROWTH FACTOR BETA%GOBP%GO:0071559	response to transforming growth factor beta	0.0035199459451595544	0.0035199459451595544	+1	SOX9,SMAD4,USP9X,TGFBR2,SMAD2
PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY	PID_BARD1_PATHWAY	0.0035199459451595544	0.0035199459451595544	+1	ATM,BRCA1,ATR
NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 81%5654726	Negative regulation of FGFR1 signaling	0.0035199459451595544	0.0035199459451595544	+1	BRAF,PPP2R1A,PTPN11
DOPAMINERGIC NEURON DIFFERENTIATION%GOBP%GO:0071542	dopaminergic neuron differentiation	0.0035199459451595544	0.0035199459451595544	+1	CTNNB1,FOXA1,FOXA2
TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 81%937061	TRIF (TICAM1)-mediated TLR4 signaling	0.0035199459451595544	0.0035199459451595544	+1	TP53,MAP2K4,TLR4,PPP2R1A,PTPN11
OTIC VESICLE DEVELOPMENT%GOBP%GO:0071599	otic vesicle development	0.0035199459451595544	0.0035199459451595544	+1	SOX9,FGFR2
ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS	ALK1 signaling events	0.0035199459451595544	0.0035199459451595544	+1	SMAD4,TGFBR2,ACVR2A
RESPONSE TO LITHIUM ION%GOBP%GO:0010226	response to lithium ion	0.0035199459451595544	0.0035199459451595544	+1	CDH1,CDKN1B
LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 81%9022537	Loss of MECP2 binding ability to the NCoR SMRT complex	0.0035199459451595544	0.0035199459451595544	+1	TBL1XR1,NCOR1
NEGATIVE REGULATION OF FATTY ACID METABOLIC PROCESS%GOBP%GO:0045922	negative regulation of fatty acid metabolic process	0.0035199459451595544	0.0035199459451595544	+1	SOX9,BRCA1,NCOR1
BURN WOUND HEALING%WIKIPATHWAYS_20240510%WP5055%HOMO SAPIENS	Burn wound healing	0.0035199459451595544	0.0035199459451595544	+1	HGF,TLR4,FGFR2,FGFR3
POSITIVE REGULATION OF MALE GONAD DEVELOPMENT%GOBP%GO:2000020	positive regulation of male gonad development	0.0035199459451595544	0.0035199459451595544	+1	SOX9,WT1
POSITIVE REGULATION OF GONAD DEVELOPMENT%GOBP%GO:1905941	positive regulation of gonad development	0.0035199459451595544	0.0035199459451595544	+1	SOX9,WT1
POSITIVE REGULATION OF DNA BIOSYNTHETIC PROCESS%GOBP%GO:2000573	positive regulation of DNA biosynthetic process	0.0035199459451595544	0.0035199459451595544	+1	CTNNB1,ATM,HGF,ATR
REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING%GOBP%GO:1904356	regulation of telomere maintenance via telomere lengthening	0.0035199459451595544	0.0035199459451595544	+1	TP53,CTNNB1,ATM,ATR
DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 81%186763	Downstream signal transduction	0.0035199459451595544	0.0035199459451595544	+1	PIK3CA,PDGFRA,PTPN11
CRANIAL SKELETAL SYSTEM DEVELOPMENT%GOBP%GO:1904888	cranial skeletal system development	0.0035199459451595544	0.0035199459451595544	+1	PDGFRA,FGFR2,TGFBR2
SUBTELOMERIC HETEROCHROMATIN FORMATION%GOBP%GO:0031509	subtelomeric heterochromatin formation	0.0035199459451595544	0.0035199459451595544	+1	ATRX,EZH2
LDLRAD4 AND WHAT WE KNOW ABOUT IT%WIKIPATHWAYS_20240510%WP4904%HOMO SAPIENS	LDLRAD4 and what we know about it	0.0035199459451595544	0.0035199459451595544	+1	TGFBR2,SMAD2
MRNA PROTEIN AND METABOLITE INDUCATION PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20240510%WP3953%HOMO SAPIENS	mRNA protein and metabolite inducation pathway by cyclosporin A	0.0035199459451595544	0.0035199459451595544	+1	KEAP1,NFE2L2
PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4	PTK6 promotes HIF1A stabilization	0.0035199459451595544	0.0035199459451595544	+1	EGFR,LRRK2
NEGATIVE REGULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL%GOBP%GO:0090394	negative regulation of excitatory postsynaptic potential	0.0035199459451595544	0.0035199459451595544	+1	PTEN,LRRK2
STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5	STAT5 Activation	0.0035199459451595544	0.0035199459451595544	+1	FLT3,PTPN11
HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5	HDMs demethylate histones	0.0035199459451595544	0.0035199459451595544	+1	KDM6A,KDM5C,ARID5B
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 81%8939256	RUNX1 regulates transcription of genes involved in WNT signaling	0.0035199459451595544	0.0035199459451595544	+1	RUNX1,CBFB
MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4	MyD88-independent TLR4 cascade	0.0035199459451595544	0.0035199459451595544	+1	TP53,MAP2K4,TLR4,PPP2R1A,PTPN11
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 81%8939245	RUNX1 regulates transcription of genes involved in BCR signaling	0.0035199459451595544	0.0035199459451595544	+1	RUNX1,CBFB
REGULATION OF PROTEIN AUTOUBIQUITINATION%GOBP%GO:1902498	regulation of protein autoubiquitination	0.0035199459451595544	0.0035199459451595544	+1	LRRK2,TAF1
REGULATION OF CD4-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	0.0035199459451595544	0.0035199459451595544	+1	RUNX1,EP300,TGFBR2,CBFB
LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 81%3656534	Loss of Function of TGFBR1 in Cancer	0.0035199459451595544	0.0035199459451595544	+1	TGFBR2,SMAD2
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8939246.3	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	0.0035199459451595544	0.0035199459451595544	+1	RUNX1,CBFB
PTK6 REGULATES CELL CYCLE%REACTOME%R-HSA-8849470.2	PTK6 Regulates Cell Cycle	0.0035199459451595544	0.0035199459451595544	+1	CDKN1B,CCND1
RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 81%8931987	RUNX1 regulates estrogen receptor mediated transcription	0.0035199459451595544	0.0035199459451595544	+1	RUNX1,CBFB
REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	0.0035867830032807364	0.0035867830032807364	+1	BRCA1,FOXA1,EP300,NCOR1
NEGATIVE REGULATION OF G2/M TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	0.0035867830032807364	0.0035867830032807364	+1	ATM,BRCA1,CDKN1A,ATR
REGULATION OF RECEPTOR SIGNALING PATHWAY VIA JAK-STAT%GOBP%GO:0046425	regulation of receptor signaling pathway via JAK-STAT	0.0035867830032807364	0.0035867830032807364	+1	VHL,NOTCH1,KIT,EP300
KIDNEY EPITHELIUM DEVELOPMENT%GOBP%GO:0072073	kidney epithelium development	0.0035867830032807364	0.0035867830032807364	+1	GATA3,SOX9,WT1,FGFR2
ADIPOGENESIS%REACTOME DATABASE ID RELEASE 81%9843745	Adipogenesis	0.0036655092789670374	0.0036655092789670374	+1	CEBPA,EP300,SMAD4,TBL1XR1,NCOR1
POSITIVE REGULATION OF BINDING%GOBP%GO:0051099	positive regulation of binding	0.0036655092789670374	0.0036655092789670374	+1	GATA3,RB1,LRRK2,USP9X,TAF1
CYTOPROTECTION BY HMOX1%REACTOME%R-HSA-9707564.5	Cytoprotection by HMOX1	0.0037901198311833615	0.0037901198311833615	+1	NFE2L2,SIN3A,TBL1XR1,NCOR1
REGULATION OF STEM CELL DIFFERENTIATION%GOBP%GO:2000736	regulation of stem cell differentiation	0.0037901198311833615	0.0037901198311833615	+1	NOTCH1,SOX9,PDGFRA,TGFBR2
RESPONSE TO RETINOIC ACID%GOBP%GO:0032526	response to retinoic acid	0.0037901198311833615	0.0037901198311833615	+1	EPHA3,SOX9,ATM,ASXL1
FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20240510%WP4767%HOMO SAPIENS	FGFR3 signaling in chondrocyte proliferation and terminal differentiation	0.003798436783192138	0.003798436783192138	+1	SOX9,FGFR3,CDKN1A
BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY	BIOCARTA_MET_PATHWAY	0.003798436783192138	0.003798436783192138	+1	PTEN,HGF,PTPN11
RESPONSE TO INTERLEUKIN-6%GOBP%GO:0070741	response to interleukin-6	0.003798436783192138	0.003798436783192138	+1	CEBPA,SMAD4,FOXA2
RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 81%5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.003798436783192138	0.003798436783192138	+1	ATM,BRCA1,BRCA2
SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III	Signaling events mediated by HDAC Class III	0.003798436783192138	0.003798436783192138	+1	TP53,EP300,CDKN1A
REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20240510%WP4838%HOMO SAPIENS	Regucalcin in proximal tubule epithelial kidney cells	0.003798436783192138	0.003798436783192138	+1	BRAF,SMAD4,SMAD2
NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-HSA-5654733.3	Negative regulation of FGFR4 signaling	0.003798436783192138	0.003798436783192138	+1	BRAF,PPP2R1A,PTPN11
VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20240510%WP2877%HOMO SAPIENS	Vitamin D receptor pathway	0.0038396323531591707	0.0038396323531591707	+1	CDKN2A,CEBPA,CDKN1B,CCND1,CDKN1A,CDKN2C
HOMEOSTASIS OF NUMBER OF CELLS%GOBP%GO:0048872	homeostasis of number of cells	0.0039163770494567846	0.0039163770494567846	+1	NOTCH1,FLT3,SOX9,KIT,PPP2R1A
MALE INFERTILITY%WIKIPATHWAYS_20240510%WP4673%HOMO SAPIENS	Male infertility	0.0039163770494567846	0.0039163770494567846	+1	NFE2L2,ATM,EP300,BRCA2,ERCC2
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	0.0039587284235168595	0.0039587284235168595	+1	RUNX1,EP300,CBFB,SIN3A
INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS	Integrins in angiogenesis	0.0039587284235168595	0.0039587284235168595	+1	PIK3CA,CDKN1B,TGFBR2,PTPN11
NEGATIVE REGULATION OF CELL CYCLE G2/M PHASE TRANSITION%GOBP%GO:1902750	negative regulation of cell cycle G2/M phase transition	0.0039587284235168595	0.0039587284235168595	+1	ATM,BRCA1,CDKN1A,ATR
RESPONSE TO REACTIVE OXYGEN SPECIES%GOBP%GO:0000302	response to reactive oxygen species	0.0040486581964391385	0.0040486581964391385	+1	EGFR,NFE2L2,ATM,LRRK2,PDGFRA
SIGNALING BY NTRK1 (TRKA)%REACTOME DATABASE ID RELEASE 81%187037	Signaling by NTRK1 (TRKA)	0.0040486581964391385	0.0040486581964391385	+1	PIK3CA,BRAF,EP300,PPP2R1A,EGR3
INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 81%6785807	Interleukin-4 and Interleukin-13 signaling	0.0040486581964391385	0.0040486581964391385	+1	TP53,GATA3,HGF,CCND1,CDKN1A
MAMMARY GLAND DEVELOPMENT PATHWAY PREGNANCY AND LACTATION STAGE 3 OF 4 %WIKIPATHWAYS_20240510%WP2817%HOMO SAPIENS	Mammary gland development pathway Pregnancy and lactation Stage 3 of 4	0.0041423752880314505	0.0041423752880314505	+1	EGFR,CEBPA,CCND1
NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME%R-HSA-5654727.3	Negative regulation of FGFR2 signaling	0.0041423752880314505	0.0041423752880314505	+1	BRAF,PPP2R1A,PTPN11
PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY	PID_MET_PATHWAY	0.0041423752880314505	0.0041423752880314505	+1	CTNNB1,MAP2K4,HGF,PTPN11
NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 81%350054	Notch-HLH transcription pathway	0.0041423752880314505	0.0041423752880314505	+1	NOTCH1,TBL1XR1,NCOR1
ANGIOGENESIS%GOBP%GO:0001525	angiogenesis	0.0041423752880314505	0.0041423752880314505	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
AUTONOMIC NERVOUS SYSTEM DEVELOPMENT%GOBP%GO:0048483	autonomic nervous system development	0.0041423752880314505	0.0041423752880314505	+1	NF1,GATA3,CTNNB1
SIGNALING BY ALK%REACTOME%R-HSA-201556.5	Signaling by ALK	0.0041423752880314505	0.0041423752880314505	+1	PIK3CA,EP300,SIN3A
REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 81%9022692	Regulation of MECP2 expression and activity	0.0041423752880314505	0.0041423752880314505	+1	SIN3A,TBL1XR1,NCOR1
MITOTIC CELL CYCLE PHASE TRANSITION%GOBP%GO:0044772	mitotic cell cycle phase transition	0.004338923325215737	0.004338923325215737	+1	CDKN1B,CHEK2,CCND1,CDKN1A,ACVR1B
SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 81%5654738	Signaling by FGFR2	0.004375690326444819	0.004375690326444819	+1	PIK3CA,BRAF,PPP2R1A,PTPN11
NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001234	negative regulation of apoptotic signaling pathway	0.004375690326444819	0.004375690326444819	+1	RB1,NFE2L2,AR,HGF,BRCA1,LRRK2
AXONOGENESIS%GOBP%GO:0007409	axonogenesis	0.0044316718412205905	0.0044316718412205905	+1	PTEN,NOTCH1,ARHGAP35,EPHA3,FGFR2,EPHB6,USP9X
MYELOID CELL DIFFERENTIATION%GOBP%GO:0030099	myeloid cell differentiation	0.00449852854093047	0.00449852854093047	+1	GATA3,RUNX1,CEBPA,TET2,KIT,TGFBR2
EMBRYONIC AXIS SPECIFICATION%GOBP%GO:0000578	embryonic axis specification	0.004533580096182888	0.004533580096182888	+1	TBX3,WT1,SMAD2
CELLULAR RESPONSE TO EPIDERMAL GROWTH FACTOR STIMULUS%GOBP%GO:0071364	cellular response to epidermal growth factor stimulus	0.004533580096182888	0.004533580096182888	+1	EGFR,SOX9,PTPN11
HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20240510%WP313%HOMO SAPIENS	Hepatocyte growth factor receptor signaling	0.004533580096182888	0.004533580096182888	+1	PTEN,HGF,PTPN11
NEPHRON TUBULE MORPHOGENESIS%GOBP%GO:0072078	nephron tubule morphogenesis	0.004533580096182888	0.004533580096182888	+1	GATA3,SOX9,WT1
CAMKK2 PATHWAY%WIKIPATHWAYS_20240510%WP4874%HOMO SAPIENS	CAMKK2 pathway	0.004533580096182888	0.004533580096182888	+1	NFE2L2,EP300,SMC1A
INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20240510%WP4844%HOMO SAPIENS	Influence of laminopathies on Wnt signaling	0.004533580096182888	0.004533580096182888	+1	CTNNB1,CEBPA,CCND1
LOCOMOTOR RHYTHM%GOBP%GO:0045475	locomotor rhythm	0.00454999749397154	0.00454999749397154	+1	PTEN,NCOR1
DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20240510%WP3300%HOMO SAPIENS	Dual hijack model of Vif in HIV infection	0.00454999749397154	0.00454999749397154	+1	RUNX1,CBFB
BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL	BMP Signalling Pathway	0.00454999749397154	0.00454999749397154	+1	SMAD4,ACVR2A
BIOCARTA_FBW7_PATHWAY%MSIGDB_C2%BIOCARTA_FBW7_PATHWAY	BIOCARTA_FBW7_PATHWAY	0.00454999749397154	0.00454999749397154	+1	RB1,FBXW7
SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2	Signaling events mediated by VEGFR1 and VEGFR2	0.00454999749397154	0.00454999749397154	+1	PIK3CA,CTNNB1,BRAF,PTPN11
CELLULAR RESPONSE TO GONADOTROPIN STIMULUS%GOBP%GO:0071371	cellular response to gonadotropin stimulus	0.00454999749397154	0.00454999749397154	+1	NOTCH1,WT1
NEGATIVE REGULATION OF OLIGODENDROCYTE DIFFERENTIATION%GOBP%GO:0048715	negative regulation of oligodendrocyte differentiation	0.00454999749397154	0.00454999749397154	+1	NF1,NOTCH1
NRF2 PATHWAY%WIKIPATHWAYS_20240510%WP2884%HOMO SAPIENS	NRF2 pathway	0.00454999749397154	0.00454999749397154	+1	KEAP1,NFE2L2,EPHA3,HGF,TGFBR2
BIOCARTA_MELANOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MELANOCYTE_PATHWAY	BIOCARTA_MELANOCYTE_PATHWAY	0.00454999749397154	0.00454999749397154	+1	KIT,EP300
ATRIOVENTRICULAR VALVE FORMATION%GOBP%GO:0003190	atrioventricular valve formation	0.00454999749397154	0.00454999749397154	+1	NOTCH1,SMAD4
MAMMARY GLAND MORPHOGENESIS%GOBP%GO:0060443	mammary gland morphogenesis	0.00454999749397154	0.00454999749397154	+1	ELF3,FGFR2
POSITIVE REGULATION OF PROTEIN-CONTAINING COMPLEX ASSEMBLY%GOBP%GO:0031334	positive regulation of protein-containing complex assembly	0.00454999749397154	0.00454999749397154	+1	TP53,NAV3,AJUBA,ATM,TLR4,ATR
REGULATION OF MALE GONAD DEVELOPMENT%GOBP%GO:2000018	regulation of male gonad development	0.00454999749397154	0.00454999749397154	+1	SOX9,WT1
NEPHRON TUBULE FORMATION%GOBP%GO:0072079	nephron tubule formation	0.00454999749397154	0.00454999749397154	+1	GATA3,SOX9
AXIS ELONGATION%GOBP%GO:0003401	axis elongation	0.00454999749397154	0.00454999749397154	+1	SOX9,FGFR2
APOPTOSIS%REACTOME DATABASE ID RELEASE 81%109581	Apoptosis	0.00478682218035648	0.00478682218035648	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,TLR4
JNK CASCADE%GOBP%GO:0007254	JNK cascade	0.004889338271983531	0.004889338271983531	+1	MAP2K4,LRRK2,MAPK8IP1
NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20240510%WP4331%HOMO SAPIENS	Neovascularization processes	0.004889338271983531	0.004889338271983531	+1	NOTCH1,KIT,SMAD2
FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.004889338271983531	0.004889338271983531	+1	SMAD4,SIN3A,SMAD2
NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY	Nectin adhesion pathway	0.004889338271983531	0.004889338271983531	+1	PIK3CA,CTNNB1,CDH1
POSITIVE REGULATION OF TELOMERE MAINTENANCE%GOBP%GO:0032206	positive regulation of telomere maintenance	0.005000390402080903	0.005000390402080903	+1	CTNNB1,ATM,ATRX,ATR
ENDOTHELIUM DEVELOPMENT%GOBP%GO:0003158	endothelium development	0.0052693874613152815	0.0052693874613152815	+1	NOTCH1,CTNNB1,SMAD4,SOX17
HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 81%5685942	HDR through Homologous Recombination (HRR)	0.0052693874613152815	0.0052693874613152815	+1	ATM,BRCA1,BRCA2,ATR
MITOTIC G2 DNA DAMAGE CHECKPOINT SIGNALING%GOBP%GO:0007095	mitotic G2 DNA damage checkpoint signaling	0.005335241371926457	0.005335241371926457	+1	ATM,BRCA1,CDKN1A
URETERIC BUD DEVELOPMENT%GOBP%GO:0001657	ureteric bud development	0.005335241371926457	0.005335241371926457	+1	GATA3,WT1,FGFR2
AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING	Aurora A signaling	0.005335241371926457	0.005335241371926457	+1	TP53,AJUBA,BRCA1
POSITIVE REGULATION OF PHOSPHOLIPASE C ACTIVITY%GOBP%GO:0010863	positive regulation of phospholipase C activity	0.005335241371926457	0.005335241371926457	+1	EGFR,KIT,PDGFRA
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 81%4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.005335241371926457	0.005335241371926457	+1	APC,CTNNB1,PPP2R1A
RAS PATHWAY%PANTHER PATHWAY%P04393	Ras Pathway	0.005507122309094198	0.005507122309094198	+1	PIK3CA,MAP2K4,BRAF,PIK3CG
REGULATION OF RECEPTOR SIGNALING PATHWAY VIA STAT%GOBP%GO:1904892	regulation of receptor signaling pathway via STAT	0.005507122309094198	0.005507122309094198	+1	VHL,NOTCH1,KIT,EP300
DISEASES OF PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 81%9645723	Diseases of programmed cell death	0.005507122309094198	0.005507122309094198	+1	TP53,CDKN2A,DNMT3A,EZH2
MICROTUBULE CYTOSKELETON ORGANIZATION INVOLVED IN MITOSIS%GOBP%GO:1902850	microtubule cytoskeleton organization involved in mitosis	0.005600528797990277	0.005600528797990277	+1	STAG2,CHEK2,SETD2,SMC1A,SMC3
MESONEPHRIC EPITHELIUM DEVELOPMENT%GOBP%GO:0072163	mesonephric epithelium development	0.0056654147562893884	0.0056654147562893884	+1	GATA3,WT1,FGFR2
RENAL TUBULE MORPHOGENESIS%GOBP%GO:0061333	renal tubule morphogenesis	0.0056654147562893884	0.0056654147562893884	+1	GATA3,SOX9,WT1
BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY	BIOCARTA_ALK_PATHWAY	0.0056654147562893884	0.0056654147562893884	+1	CTNNB1,SMAD4,TGFBR2
CARDIAC CELL FATE COMMITMENT%GOBP%GO:0060911	cardiac cell fate commitment	0.0056654147562893884	0.0056654147562893884	+1	WT1,SOX17
POSITIVE REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	0.0056654147562893884	0.0056654147562893884	+1	RUNX1,CBFB
HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION%GOBP%GO:0002244	hematopoietic progenitor cell differentiation	0.0056654147562893884	0.0056654147562893884	+1	TP53,FLT3,KIT
RESPONSE TO EPIDERMAL GROWTH FACTOR%GOBP%GO:0070849	response to epidermal growth factor	0.0056654147562893884	0.0056654147562893884	+1	EGFR,SOX9,PTPN11
NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20240510%WP5119%HOMO SAPIENS	NIPBL role in DNA damage Cornelia de Lange syndrome	0.0056654147562893884	0.0056654147562893884	+1	ATM,ATR
NEPHRON MORPHOGENESIS%GOBP%GO:0072028	nephron morphogenesis	0.0056654147562893884	0.0056654147562893884	+1	GATA3,SOX9,WT1
EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 81%9009391	Extra-nuclear estrogen signaling	0.0056654147562893884	0.0056654147562893884	+1	PIK3CA,EGFR,CDKN1B,CCND1
PROSTATE GLAND DEVELOPMENT%GOBP%GO:0030850	prostate gland development	0.0056654147562893884	0.0056654147562893884	+1	SOX9,FGFR2
NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME DATABASE ID RELEASE 81%9818032	NFE2L2 regulating MDR associated enzymes	0.0056654147562893884	0.0056654147562893884	+1	NFE2L2,EP300
EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY	EGF receptor (ErbB1) signaling pathway	0.0056654147562893884	0.0056654147562893884	+1	PIK3CA,EGFR,PTPN11
RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 81%8951430	RUNX3 regulates WNT signaling	0.0056654147562893884	0.0056654147562893884	+1	CTNNB1,CCND1
IMMATURE B CELL DIFFERENTIATION%GOBP%GO:0002327	immature B cell differentiation	0.0056654147562893884	0.0056654147562893884	+1	ATM,KIT
BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851	Bile Acid Indirect Signalling Pathway	0.0056654147562893884	0.0056654147562893884	+1	FGFR2,FGFR3
REGULATION OF MAMMARY GLAND EPITHELIAL CELL PROLIFERATION%GOBP%GO:0033599	regulation of mammary gland epithelial cell proliferation	0.0056654147562893884	0.0056654147562893884	+1	GATA3,BRCA2
CONSTITUTIVE HETEROCHROMATIN FORMATION%GOBP%GO:0140719	constitutive heterochromatin formation	0.0056654147562893884	0.0056654147562893884	+1	ATRX,EZH2
POSITIVE REGULATION OF CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	0.0056654147562893884	0.0056654147562893884	+1	NOTCH1,TGFBR2
NEGATIVE REGULATION OF CHROMOSOME ORGANIZATION%GOBP%GO:2001251	negative regulation of chromosome organization	0.0056654147562893884	0.0056654147562893884	+1	TP53,APC,ATM,ATRX
NEPHRON EPITHELIUM MORPHOGENESIS%GOBP%GO:0072088	nephron epithelium morphogenesis	0.0056654147562893884	0.0056654147562893884	+1	GATA3,SOX9,WT1
NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2	NFE2L2 regulates pentose phosphate pathway genes	0.0056654147562893884	0.0056654147562893884	+1	NFE2L2,EP300
RESPONSE TO GONADOTROPIN%GOBP%GO:0034698	response to gonadotropin	0.0056654147562893884	0.0056654147562893884	+1	NOTCH1,WT1
NEGATIVE REGULATION OF KERATINOCYTE PROLIFERATION%GOBP%GO:0010839	negative regulation of keratinocyte proliferation	0.0056654147562893884	0.0056654147562893884	+1	EPPK1,FGFR2
REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation	0.0056654147562893884	0.0056654147562893884	+1	RUNX1,CBFB
RESPONSE TO ESTRADIOL%GOBP%GO:0032355	response to estradiol	0.0056654147562893884	0.0056654147562893884	+1	EGFR,CTNNB1,FOXA1
STRESS-INDUCED PREMATURE SENESCENCE%GOBP%GO:0090400	stress-induced premature senescence	0.0056654147562893884	0.0056654147562893884	+1	TP53,CDKN1A
HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 81%5693538	Homology Directed Repair	0.0056654147562893884	0.0056654147562893884	+1	ATM,BRCA1,POLQ,BRCA2,ATR
BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 81%4411364	Binding of TCF LEF:CTNNB1 to target gene promoters	0.0056654147562893884	0.0056654147562893884	+1	CTNNB1,AXIN2
MESONEPHRIC TUBULE DEVELOPMENT%GOBP%GO:0072164	mesonephric tubule development	0.0056654147562893884	0.0056654147562893884	+1	GATA3,WT1,FGFR2
REGULATION OF GONAD DEVELOPMENT%GOBP%GO:1905939	regulation of gonad development	0.0056654147562893884	0.0056654147562893884	+1	SOX9,WT1
BIOCARTA_BTG2_PATHWAY%MSIGDB_C2%BIOCARTA_BTG2_PATHWAY	BIOCARTA_BTG2_PATHWAY	0.0056654147562893884	0.0056654147562893884	+1	RB1,CCND1
OVARIAN INFERTILITY%WIKIPATHWAYS_20240510%WP34%HOMO SAPIENS	Ovarian infertility	0.0056654147562893884	0.0056654147562893884	+1	ATM,CDKN1B,NCOR1
ENDOCHONDRAL BONE GROWTH%GOBP%GO:0003416	endochondral bone growth	0.0056654147562893884	0.0056654147562893884	+1	SOX9,FGFR3
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.2	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	0.0056654147562893884	0.0056654147562893884	+1	RUNX1,CBFB
SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 81%1980143	Signaling by NOTCH1	0.005853660005181678	0.005853660005181678	+1	NOTCH1,EP300,TBL1XR1,NCOR1
CELLULAR RESPONSE TO METAL ION%GOBP%GO:0071248	cellular response to metal ion	0.005970620791705806	0.005970620791705806	+1	EGFR,CDH1,BRAF,CDKN1B,LRRK2
CELL CYCLE PHASE TRANSITION%GOBP%GO:0044770	cell cycle phase transition	0.005970620791705806	0.005970620791705806	+1	CDKN1B,CHEK2,CCND1,CDKN1A,ACVR1B
POSITIVE REGULATION OF TELOMERE MAINTENANCE VIA TELOMERASE%GOBP%GO:0032212	positive regulation of telomere maintenance via telomerase	0.006065201295479065	0.006065201295479065	+1	CTNNB1,ATM,ATR
PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY	PID_TCPTP_PATHWAY	0.006065201295479065	0.006065201295479065	+1	EGFR,HGF,ATR
GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 81%114604	GPVI-mediated activation cascade	0.006065201295479065	0.006065201295479065	+1	PIK3CA,PIK3CG,PTPN11
HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDBHALLMARK%HALLMARK_WNT_BETA_CATENIN_SIGNALING	HALLMARK_WNT_BETA_CATENIN_SIGNALING	0.006065201295479065	0.006065201295479065	+1	NOTCH1,CTNNB1,AXIN2
PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY	PID_FRA_PATHWAY	0.006065201295479065	0.006065201295479065	+1	CDKN2A,EP300,CCND1
NEGATIVE REGULATION OF LEUKOCYTE DIFFERENTIATION%GOBP%GO:1902106	negative regulation of leukocyte differentiation	0.006098644578301237	0.006098644578301237	+1	FBXW7,RUNX1,TLR4,CBFB
EAR DEVELOPMENT%GOBP%GO:0043583	ear development	0.006098644578301237	0.006098644578301237	+1	GATA3,SOX9,FGFR2,PTPN11
PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047	PDGF signaling pathway	0.0061310003536647764	0.0061310003536647764	+1	PIK3CA,BRAF,PIK3CG,ELF3,PDGFRA
REGULATION OF CHROMOSOME SEGREGATION%GOBP%GO:0051983	regulation of chromosome segregation	0.006337913886216679	0.006337913886216679	+1	APC,ARID1A,PBRM1,RB1,ATM
NEGATIVE REGULATION OF DNA METABOLIC PROCESS%GOBP%GO:0051053	negative regulation of DNA metabolic process	0.006337913886216679	0.006337913886216679	+1	TP53,ATM,POLQ,CDKN1A,ATR
REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING%GOBP%GO:2000677	regulation of transcription regulatory region DNA binding	0.006530369583866049	0.006530369583866049	+1	GATA3,RB1,NSD1
N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS	N-cadherin signaling events	0.006530369583866049	0.006530369583866049	+1	PIK3CA,CTNNB1,PTPN11
REGULATION OF PHOSPHOLIPASE C ACTIVITY%GOBP%GO:1900274	regulation of phospholipase C activity	0.006530369583866049	0.006530369583866049	+1	EGFR,KIT,PDGFRA
PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY	PID_ATR_PATHWAY	0.006530369583866049	0.006530369583866049	+1	BRCA2,PPP2R1A,ATR
DNA-TEMPLATED DNA REPLICATION%GOBP%GO:0006261	DNA-templated DNA replication	0.006530369583866049	0.006530369583866049	+1	ATRX,BRCA1,POLQ,BRCA2,ATR
NEGATIVE REGULATION OF JNK CASCADE%GOBP%GO:0046329	negative regulation of JNK cascade	0.006530369583866049	0.006530369583866049	+1	MAPK8IP1,MECOM,NCOR1
SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 81%4791275	Signaling by WNT in cancer	0.006530369583866049	0.006530369583866049	+1	APC,CTNNB1,PPP2R1A
TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY%GOBP%GO:0007179	transforming growth factor beta receptor signaling pathway	0.006644420941951893	0.006644420941951893	+1	SMAD4,USP9X,TGFBR2,SMAD2
NEGATIVE REGULATION OF HEMOPOIESIS%GOBP%GO:1903707	negative regulation of hemopoiesis	0.006644420941951893	0.006644420941951893	+1	FBXW7,RUNX1,TLR4,CBFB
CELLULAR RESPONSE TO HYPOXIA%GOBP%GO:0071456	cellular response to hypoxia	0.006644420941951893	0.006644420941951893	+1	TP53,VHL,NOTCH1,NFE2L2
EPITHELIAL CELL MIGRATION%GOBP%GO:0010631	epithelial cell migration	0.006963803160952821	0.006963803160952821	+1	PIK3CA,KIT,SMAD4,EGR3
NCRNAS INVOLVED IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20240510%WP4336%HOMO SAPIENS	ncRNAs involved in Wnt signaling in hepatocellular carcinoma	0.006963803160952821	0.006963803160952821	+1	CTNNB1,CCND1,SOX17,EZH2
INTEGRATED STRESS RESPONSE SIGNALING%GOBP%GO:0140467	integrated stress response signaling	0.006965783116063301	0.006965783116063301	+1	NFE2L2,CEBPA,NFE2L3
NEGATIVE REGULATION OF CARDIOCYTE DIFFERENTIATION%GOBP%GO:1905208	negative regulation of cardiocyte differentiation	0.006965783116063301	0.006965783116063301	+1	EGFR,SMAD4
RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.4	Resolution of D-loop Structures through Holliday Junction Intermediates	0.006965783116063301	0.006965783116063301	+1	ATM,BRCA1,BRCA2
POSITIVE REGULATION OF CELL-CELL ADHESION MEDIATED BY CADHERIN%GOBP%GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	0.006965783116063301	0.006965783116063301	+1	FOXA1,FOXA2
ANOIKIS%GOBP%GO:0043276	anoikis	0.006965783116063301	0.006965783116063301	+1	PIK3CA,STK11
INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 81%8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.006965783116063301	0.006965783116063301	+1	CTNNB1,CDH1
POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS%GOBP%GO:0043525	positive regulation of neuron apoptotic process	0.006965783116063301	0.006965783116063301	+1	NF1,FBXW7,CTNNB1
PI5P REGULATES TP53 ACETYLATION%REACTOME%R-HSA-6811555.3	PI5P Regulates TP53 Acetylation	0.006965783116063301	0.006965783116063301	+1	TP53,EP300
CHONDROCYTE DIFFERENTIATION%GOBP%GO:0002062	chondrocyte differentiation	0.006965783116063301	0.006965783116063301	+1	RUNX1,SOX9,FGFR3
RESPONSE TO ESTROGEN%GOBP%GO:0043627	response to estrogen	0.006965783116063301	0.006965783116063301	+1	GATA3,AR,EP300
VENTRICULAR CARDIAC MUSCLE TISSUE MORPHOGENESIS%GOBP%GO:0055010	ventricular cardiac muscle tissue morphogenesis	0.006965783116063301	0.006965783116063301	+1	NOTCH1,FGFR2,SMAD4
EMBRYONIC DIGESTIVE TRACT MORPHOGENESIS%GOBP%GO:0048557	embryonic digestive tract morphogenesis	0.006965783116063301	0.006965783116063301	+1	PDGFRA,FGFR2
MONOUBIQUITINATED PROTEIN DEUBIQUITINATION%GOBP%GO:0035520	monoubiquitinated protein deubiquitination	0.006965783116063301	0.006965783116063301	+1	BAP1,USP9X
POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20240510%WP2571%HOMO SAPIENS	Polycystic kidney disease pathway	0.0071867879578954115	0.0071867879578954115	+1	CTNNB1,STK11,BRAF,CCND1
NEPHRON DEVELOPMENT%GOBP%GO:0072006	nephron development	0.0071867879578954115	0.0071867879578954115	+1	GATA3,SOX9,WT1,PDGFRA
GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959	Gastrin_CCK2R_240212	0.0072884355752798275	0.0072884355752798275	+1	CTNNB1,CDH1,MAP2K4,BRAF,PTPN11
G1 S TRANSITION%REACTOME DATABASE ID RELEASE 81%69206	G1 S Transition	0.0072884355752798275	0.0072884355752798275	+1	RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A
RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 81%5693537	Resolution of D-Loop Structures	0.007397653977500956	0.007397653977500956	+1	ATM,BRCA1,BRCA2
NEPHRON TUBULE DEVELOPMENT%GOBP%GO:0072080	nephron tubule development	0.007397653977500956	0.007397653977500956	+1	GATA3,SOX9,WT1
MESONEPHROS DEVELOPMENT%GOBP%GO:0001823	mesonephros development	0.007397653977500956	0.007397653977500956	+1	GATA3,WT1,FGFR2
PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY	PID_ECADHERIN_STABILIZATION_PATHWAY	0.007397653977500956	0.007397653977500956	+1	EGFR,CTNNB1,HGF
ANTERIOR/POSTERIOR AXIS SPECIFICATION%GOBP%GO:0009948	anterior/posterior axis specification	0.007397653977500956	0.007397653977500956	+1	TBX3,WT1,FOXA2
POSITIVE REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING%GOBP%GO:1904358	positive regulation of telomere maintenance via telomere lengthening	0.007397653977500956	0.007397653977500956	+1	CTNNB1,ATM,ATR
INTRINSIC APOPTOTIC SIGNALING PATHWAY BY P53 CLASS MEDIATOR%GOBP%GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	0.007397653977500956	0.007397653977500956	+1	TP53,STK11,EP300
T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20240510%WP5098%HOMO SAPIENS	T cell activation SARS CoV 2	0.007397653977500956	0.007397653977500956	+1	PTEN,CDKN2A,CCND1,CDKN1A
CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING	CD40 CD40L signaling	0.007397653977500956	0.007397653977500956	+1	PIK3CA,MAP2K4,PIK3CG
EPITHELIUM MIGRATION%GOBP%GO:0090132	epithelium migration	0.007397653977500956	0.007397653977500956	+1	PIK3CA,KIT,SMAD4,EGR3
SIGNALING BY FGFR%REACTOME%R-HSA-190236.4	Signaling by FGFR	0.007397653977500956	0.007397653977500956	+1	PIK3CA,BRAF,PPP2R1A,PTPN11
LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2	LXRs regulate gene expression linked to cholesterol transport and efflux	0.007397653977500956	0.007397653977500956	+1	EP300,TBL1XR1,NCOR1
PI3K CASCADE%REACTOME%R-HSA-109704.7	PI3K Cascade	0.007397653977500956	0.007397653977500956	+1	PIK3CA,FLT3,PTPN11
SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6	SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription	0.007397653977500956	0.007397653977500956	+1	EP300,SMAD4,SMAD2
NEGATIVE REGULATION OF LIPID METABOLIC PROCESS%GOBP%GO:0045833	negative regulation of lipid metabolic process	0.007397653977500956	0.007397653977500956	+1	FBXW7,SOX9,BRCA1,NCOR1
CELLULAR RESPONSE TO DECREASED OXYGEN LEVELS%GOBP%GO:0036294	cellular response to decreased oxygen levels	0.007397653977500956	0.007397653977500956	+1	TP53,VHL,NOTCH1,NFE2L2
NUCLEAR CHROMOSOME SEGREGATION%GOBP%GO:0098813	nuclear chromosome segregation	0.007535713723833743	0.007535713723833743	+1	PTEN,RB1,STAG2,CHEK2,SMC1A,SMC3
VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION	Validated targets of C-MYC transcriptional activation	0.0077204240395473715	0.0077204240395473715	+1	TP53,NPM1,EP300,SMAD4
SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4	Senescence-Associated Secretory Phenotype (SASP)	0.0077204240395473715	0.0077204240395473715	+1	CDKN2A,CDKN1B,CDKN1A,CDKN2C
REGULATION OF MITOCHONDRION ORGANIZATION%GOBP%GO:0010821	regulation of mitochondrion organization	0.007878601312241103	0.007878601312241103	+1	TP53,FBXW7,HGF,LRRK2,EP300
POSITIVE REGULATION OF SMAD PROTEIN SIGNAL TRANSDUCTION%GOBP%GO:0060391	positive regulation of SMAD protein signal transduction	0.007900452730432562	0.007900452730432562	+1	SMAD4,TGFBR2,ACVR2A
PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY	PID_HEDGEHOG_GLI_PATHWAY	0.007900452730432562	0.007900452730432562	+1	FOXA2,SIN3A,SPOP
ROOF OF MOUTH DEVELOPMENT%GOBP%GO:0060021	roof of mouth development	0.007900452730432562	0.007900452730432562	+1	SMAD4,TGFBR2,SMAD2
NEGATIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:0048662	negative regulation of smooth muscle cell proliferation	0.007900452730432562	0.007900452730432562	+1	PTEN,CDKN1B,CDKN1A
OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20240510%WP3941%HOMO SAPIENS	Oxidative damage response	0.007900452730432562	0.007900452730432562	+1	MAP2K4,CDKN1B,CDKN1A
VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2	Validated transcriptional targets of AP1 family members Fra1 and Fra2	0.007900452730432562	0.007900452730432562	+1	CDKN2A,EP300,CCND1
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-HSA-111465.5	Apoptotic cleavage of cellular proteins	0.007900452730432562	0.007900452730432562	+1	APC,CTNNB1,CDH1
LIVER DEVELOPMENT%GOBP%GO:0001889	liver development	0.007900452730432562	0.007900452730432562	+1	NF1,CEBPA,ARID5B
HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5685938.3	HDR through Single Strand Annealing (SSA)	0.007900452730432562	0.007900452730432562	+1	ATM,BRCA1,ATR
REGULATION OF OSSIFICATION%GOBP%GO:0030278	regulation of ossification	0.00797383978304836	0.00797383978304836	+1	NOTCH1,SOX9,PTPN11,ACVR2A
DETERMINATION OF LEFT/RIGHT SYMMETRY%GOBP%GO:0007368	determination of left/right symmetry	0.00797383978304836	0.00797383978304836	+1	NOTCH1,TGFBR2,SOX17,SMAD2
HCMV EARLY EVENTS%REACTOME DATABASE ID RELEASE 81%9609690	HCMV Early Events	0.00797383978304836	0.00797383978304836	+1	EGFR,TBL1XR1,NCOR1,EZH2
REGULATION OF CELL PROLIFERATION INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:1901722	regulation of cell proliferation involved in kidney development	0.008182936226708943	0.008182936226708943	+1	GATA3,WT1
VINDESINE ACTION PATHWAY%SMPDB%SMP0000438	Vindesine Action Pathway	0.008182936226708943	0.008182936226708943	+1	TP53,CDKN1A
BONE GROWTH%GOBP%GO:0098868	bone growth	0.008182936226708943	0.008182936226708943	+1	SOX9,FGFR3
MYELIN MAINTENANCE%GOBP%GO:0043217	myelin maintenance	0.008182936226708943	0.008182936226708943	+1	PTEN,PRX
PERICARDIUM DEVELOPMENT%GOBP%GO:0060039	pericardium development	0.008182936226708943	0.008182936226708943	+1	NOTCH1,WT1
RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 81%8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	0.008182936226708943	0.008182936226708943	+1	RUNX1,CBFB
METANEPHRIC NEPHRON MORPHOGENESIS%GOBP%GO:0072273	metanephric nephron morphogenesis	0.008182936226708943	0.008182936226708943	+1	SOX9,WT1
BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY	BIOCARTA_RB_PATHWAY	0.008182936226708943	0.008182936226708943	+1	RB1,ATM
SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	0.008182936226708943	0.008182936226708943	+1	PIK3CA,PDGFRA
REGULATION OF NEPHRON TUBULE EPITHELIAL CELL DIFFERENTIATION%GOBP%GO:0072182	regulation of nephron tubule epithelial cell differentiation	0.008182936226708943	0.008182936226708943	+1	GATA3,CTNNB1
REGULATION OF MESENCHYMAL STEM CELL DIFFERENTIATION%GOBP%GO:2000739	regulation of mesenchymal stem cell differentiation	0.008182936226708943	0.008182936226708943	+1	SOX9,PDGFRA
SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2	Signaling by PDGFRA extracellular domain mutants	0.008182936226708943	0.008182936226708943	+1	PIK3CA,PDGFRA
MESENCHYMAL TO EPITHELIAL TRANSITION%GOBP%GO:0060231	mesenchymal to epithelial transition	0.008182936226708943	0.008182936226708943	+1	GATA3,WT1
VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437	Vincristine Action Pathway	0.008182936226708943	0.008182936226708943	+1	TP53,CDKN1A
LEFT/RIGHT PATTERN FORMATION%GOBP%GO:0060972	left/right pattern formation	0.008214329163613757	0.008214329163613757	+1	NOTCH1,TGFBR2,SOX17,SMAD2
HEPATICOBILIARY SYSTEM DEVELOPMENT%GOBP%GO:0061008	hepaticobiliary system development	0.008312765302002149	0.008312765302002149	+1	NF1,CEBPA,ARID5B
BONE MORPHOGENESIS%GOBP%GO:0060349	bone morphogenesis	0.008312765302002149	0.008312765302002149	+1	SOX9,FGFR2,FGFR3
RENAL TUBULE DEVELOPMENT%GOBP%GO:0061326	renal tubule development	0.008312765302002149	0.008312765302002149	+1	GATA3,SOX9,WT1
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0008543	fibroblast growth factor receptor signaling pathway	0.008312765302002149	0.008312765302002149	+1	FGFR2,FGFR3,PTPN11
REGULATION OF VASCULAR ASSOCIATED SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:1904705	regulation of vascular associated smooth muscle cell proliferation	0.008312765302002149	0.008312765302002149	+1	PTEN,CDKN1B,CDKN1A
REGULATION OF MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:1905330	regulation of morphogenesis of an epithelium	0.008312765302002149	0.008312765302002149	+1	GATA3,SOX9,HGF
PERIPHERAL NERVOUS SYSTEM DEVELOPMENT%GOBP%GO:0007422	peripheral nervous system development	0.008312765302002149	0.008312765302002149	+1	NF1,RUNX1,PRX
SISTER CHROMATID SEGREGATION%GOBP%GO:0000819	sister chromatid segregation	0.008364092271935174	0.008364092271935174	+1	RB1,STAG2,CHEK2,SMC1A,SMC3
GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK	Glucocorticoid receptor regulatory network	0.008503447398813665	0.008503447398813665	+1	TP53,GATA3,EP300,CDKN1A
TISSUE MIGRATION%GOBP%GO:0090130	tissue migration	0.008503447398813665	0.008503447398813665	+1	PIK3CA,KIT,SMAD4,EGR3
REGULATION OF DOUBLE-STRAND BREAK REPAIR%GOBP%GO:2000779	regulation of double-strand break repair	0.00880607790562473	0.00880607790562473	+1	ARID1A,PBRM1,POLQ,SETD2,ATR
TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 81%166016	Toll Like Receptor 4 (TLR4) Cascade	0.00880607790562473	0.00880607790562473	+1	TP53,MAP2K4,TLR4,PPP2R1A,PTPN11
REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 81%186712	Regulation of beta-cell development	0.00880607790562473	0.00880607790562473	+1	NOTCH1,EP300,FOXA2
INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20240510%WP5198%HOMO SAPIENS	Inflammatory bowel disease signaling	0.00880607790562473	0.00880607790562473	+1	GATA3,TLR4,SMAD2
FEMALE SEX DIFFERENTIATION%GOBP%GO:0046660	female sex differentiation	0.00880607790562473	0.00880607790562473	+1	TBX3,KIT,PDGFRA
IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 81%112399	IRS-mediated signalling	0.00880607790562473	0.00880607790562473	+1	PIK3CA,FLT3,PTPN11
CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 81%69202	Cyclin E associated events during G1 S transition	0.00880607790562473	0.00880607790562473	+1	RB1,CDKN1B,CCND1,CDKN1A
OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 81%5689896	Ovarian tumor domain proteases	0.00880607790562473	0.00880607790562473	+1	TP53,PTEN,APC
CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT%GOBP%GO:0021954	central nervous system neuron development	0.00880607790562473	0.00880607790562473	+1	PTEN,ARHGAP35,FGFR2
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 81%381340	Transcriptional regulation of white adipocyte differentiation	0.00880607790562473	0.00880607790562473	+1	CEBPA,EP300,TBL1XR1,NCOR1
PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY	PID_PS1_PATHWAY	0.00880607790562473	0.00880607790562473	+1	NOTCH1,CTNNB1,CCND1
SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 81%1433557	Signaling by SCF-KIT	0.00880607790562473	0.00880607790562473	+1	PIK3CA,KIT,PTPN11
PEPTIDYL-SERINE PHOSPHORYLATION%GOBP%GO:0018105	peptidyl-serine phosphorylation	0.00880607790562473	0.00880607790562473	+1	ATM,LRRK2,TAF1,ATR
ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY	ATR signaling pathway	0.00880607790562473	0.00880607790562473	+1	BRCA2,PPP2R1A,ATR
DETERMINATION OF BILATERAL SYMMETRY%GOBP%GO:0009855	determination of bilateral symmetry	0.009136586075731125	0.009136586075731125	+1	NOTCH1,TGFBR2,SOX17,SMAD2
SPECIFICATION OF SYMMETRY%GOBP%GO:0009799	specification of symmetry	0.009136586075731125	0.009136586075731125	+1	NOTCH1,TGFBR2,SOX17,SMAD2
PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 81%5357801	Programmed Cell Death	0.009345114065302378	0.009345114065302378	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,TLR4
INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036	Interleukin signaling pathway	0.00935193403736327	0.00935193403736327	+1	PIK3CA,BRAF,CDKN1B,CDKN1A
VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436	Vinblastine Action Pathway	0.00935193403736327	0.00935193403736327	+1	TP53,CDKN1A
GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20240510%WP4823%HOMO SAPIENS	Genes controlling nephrogenesis	0.00935193403736327	0.00935193403736327	+1	CTNNB1,WT1,FGFR2
CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6	Cyclin A:Cdk2-associated events at S phase entry	0.00935193403736327	0.00935193403736327	+1	RB1,CDKN1B,CCND1,CDKN1A
METANEPHRIC EPITHELIUM DEVELOPMENT%GOBP%GO:0072207	metanephric epithelium development	0.00935193403736327	0.00935193403736327	+1	SOX9,WT1
BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY	BIOCARTA_HIF_PATHWAY	0.00935193403736327	0.00935193403736327	+1	VHL,EP300
REGULATION OF CELLULAR RESPONSE TO HYPOXIA%GOBP%GO:1900037	regulation of cellular response to hypoxia	0.00935193403736327	0.00935193403736327	+1	VHL,AJUBA
PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20240510%WP4147%HOMO SAPIENS	PTF1A related regulatory pathway	0.00935193403736327	0.00935193403736327	+1	NOTCH1,CTNNB1
STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3	STAT3 nuclear events downstream of ALK signaling	0.00935193403736327	0.00935193403736327	+1	EP300,SIN3A
TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 81%9690406	Transcriptional regulation of testis differentiation	0.00935193403736327	0.00935193403736327	+1	SOX9,WT1
BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY	BIOCARTA_ARF_PATHWAY	0.00935193403736327	0.00935193403736327	+1	CDKN2A,RB1
VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439	Vinorelbine Action Pathway	0.00935193403736327	0.00935193403736327	+1	TP53,CDKN1A
PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY	PID_SMAD2_3PATHWAY	0.00935193403736327	0.00935193403736327	+1	SMAD4,SMAD2
POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY%GOBP%GO:0090263	positive regulation of canonical Wnt signaling pathway	0.00935193403736327	0.00935193403736327	+1	EGFR,LRRK2,FGFR2,TBL1XR1
NEGATIVE REGULATION OF CENTROSOME CYCLE%GOBP%GO:0046606	negative regulation of centrosome cycle	0.00935193403736327	0.00935193403736327	+1	NPM1,BRCA1
ARTERY MORPHOGENESIS%GOBP%GO:0048844	artery morphogenesis	0.00935193403736327	0.00935193403736327	+1	NF1,NOTCH1,TGFBR2
PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY	PID_RHOA_PATHWAY	0.00935193403736327	0.00935193403736327	+1	PTEN,MAP2K4,CDKN1B
LOCOMOTORY BEHAVIOR%GOBP%GO:0007626	locomotory behavior	0.00935193403736327	0.00935193403736327	+1	PTEN,FOXA2,NCOR1
BIOCARTA_HSWI_SNF_PATHWAY%MSIGDB_C2%BIOCARTA_HSWI_SNF_PATHWAY	BIOCARTA_HSWI_SNF_PATHWAY	0.00935193403736327	0.00935193403736327	+1	ARID1A,NF1
MITRAL VALVE MORPHOGENESIS%GOBP%GO:0003183	mitral valve morphogenesis	0.00935193403736327	0.00935193403736327	+1	NOTCH1,AXIN2
RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 81%5626467	RHO GTPases activate IQGAPs	0.00935193403736327	0.00935193403736327	+1	CTNNB1,CDH1
HEMATOPOIETIC STEM CELL PROLIFERATION%GOBP%GO:0071425	hematopoietic stem cell proliferation	0.00935193403736327	0.00935193403736327	+1	RUNX1,MECOM
BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY	BIOCARTA_PPARA_PATHWAY	0.00935193403736327	0.00935193403736327	+1	RB1,EP300,NCOR1
BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY	BIOCARTA_CBL_PATHWAY	0.00935193403736327	0.00935193403736327	+1	EGFR,PDGFRA
NEGATIVE REGULATION OF CENTROSOME DUPLICATION%GOBP%GO:0010826	negative regulation of centrosome duplication	0.00935193403736327	0.00935193403736327	+1	NPM1,BRCA1
BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY	BIOCARTA_P27_PATHWAY	0.00935193403736327	0.00935193403736327	+1	RB1,CDKN1B
REGULATION OF CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0062042	regulation of cardiac epithelial to mesenchymal transition	0.00935193403736327	0.00935193403736327	+1	NOTCH1,TGFBR2
AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20240510%WP3678%HOMO SAPIENS	Amplification and expansion of oncogenic pathways as metastatic traits	0.00935193403736327	0.00935193403736327	+1	VHL,NOTCH1
RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20240510%WP3873%HOMO SAPIENS	RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis	0.00935193403736327	0.00935193403736327	+1	PTEN,EGFR
POSITIVE REGULATION OF RECEPTOR SIGNALING PATHWAY VIA JAK-STAT%GOBP%GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	0.00935193403736327	0.00935193403736327	+1	NOTCH1,KIT,EP300
ADRENAL GLAND DEVELOPMENT%GOBP%GO:0030325	adrenal gland development	0.00935193403736327	0.00935193403736327	+1	NF1,WT1
APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 81%351906	Apoptotic cleavage of cell adhesion proteins	0.00935193403736327	0.00935193403736327	+1	CTNNB1,CDH1
HEART LOOPING%GOBP%GO:0001947	heart looping	0.00935193403736327	0.00935193403736327	+1	NOTCH1,TGFBR2,SOX17
PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY	PID_ERBB1_DOWNSTREAM_PATHWAY	0.00960078881329582	0.00960078881329582	+1	EGFR,MAP2K4,BRAF,PPP2R1A
REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:0048660	regulation of smooth muscle cell proliferation	0.00960078881329582	0.00960078881329582	+1	PTEN,CTNNB1,CDKN1B,CDKN1A
VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0003229	ventricular cardiac muscle tissue development	0.009723633252129212	0.009723633252129212	+1	NOTCH1,FGFR2,SMAD4
NEGATIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS%GOBP%GO:0045912	negative regulation of carbohydrate metabolic process	0.009723633252129212	0.009723633252129212	+1	EP300,FOXA2,NCOR1
SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7	SUMOylation of transcription cofactors	0.009723633252129212	0.009723633252129212	+1	NPM1,EP300,SIN3A
REGULATION OF PROTEIN TARGETING TO MITOCHONDRION%GOBP%GO:1903214	regulation of protein targeting to mitochondrion	0.009723633252129212	0.009723633252129212	+1	FBXW7,BAP1,LRRK2
BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY	BIOCARTA_KERATINOCYTE_PATHWAY	0.009723633252129212	0.009723633252129212	+1	EGFR,MAP2K4,CEBPA
IL 4 SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP395%HOMO SAPIENS	IL 4 signaling pathway	0.009723633252129212	0.009723633252129212	+1	CEBPA,EP300,PTPN11
IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY	IFN-gamma pathway	0.009723633252129212	0.009723633252129212	+1	PIK3CA,EP300,PTPN11
BONE DEVELOPMENT%GOBP%GO:0060348	bone development	0.009935670173556501	0.009935670173556501	+1	TP53,SOX9,FGFR2,FGFR3
GASTRULATION%GOBP%GO:0007369	gastrulation	0.010338252106437022	0.010338252106437022	+1	SETD2,FOXA2,SOX17,SMAD2
MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20240510%WP5353%HOMO SAPIENS	Macrophage stimulating protein MSP signaling	0.010338252106437022	0.010338252106437022	+1	PTEN,CTNNB1,PDGFRA,SMAD2
NEGATIVE REGULATION OF GLIAL CELL DIFFERENTIATION%GOBP%GO:0045686	negative regulation of glial cell differentiation	0.010759447034272888	0.010759447034272888	+1	NF1,NOTCH1
REGULATION OF COLD-INDUCED THERMOGENESIS%GOBP%GO:0120161	regulation of cold-induced thermogenesis	0.010759447034272888	0.010759447034272888	+1	APC,RB1,NOTCH1,STK11,TLR4
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME DATABASE ID RELEASE 81%6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.010759447034272888	0.010759447034272888	+1	TP53,ATM
CELLULAR RESPONSE TO RETINOIC ACID%GOBP%GO:0071300	cellular response to retinoic acid	0.010759447034272888	0.010759447034272888	+1	EPHA3,SOX9,ATM
FLK2 FLT3%IOB%FLK2 FLT3	FLK2 FLT3	0.010759447034272888	0.010759447034272888	+1	FLT3,CEBPA
NEGATIVE REGULATION OF PROTEIN DEPOLYMERIZATION%GOBP%GO:1901880	negative regulation of protein depolymerization	0.010759447034272888	0.010759447034272888	+1	PIK3CA,APC,NAV3
SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME DATABASE ID RELEASE 81%9827857	Specification of primordial germ cells	0.010759447034272888	0.010759447034272888	+1	TET2,SOX17
TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20240510%WP4533%HOMO SAPIENS	Transcription co factors SKI and SKIL protein partners	0.010759447034272888	0.010759447034272888	+1	NF1,SIN3A
HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20240510%WP186%HOMO SAPIENS	Homologous recombination	0.010759447034272888	0.010759447034272888	+1	ATM,BRCA2
METANEPHROS MORPHOGENESIS%GOBP%GO:0003338	metanephros morphogenesis	0.010759447034272888	0.010759447034272888	+1	SOX9,WT1
BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY	BIOCARTA_PS1_PATHWAY	0.010759447034272888	0.010759447034272888	+1	NOTCH1,CTNNB1
MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME DATABASE ID RELEASE 81%9816359	Maternal to zygotic transition (MZT)	0.010759447034272888	0.010759447034272888	+1	TP53,KDM6A,EP300,EIF4A2
CELLULAR RESPONSE TO UV-B%GOBP%GO:0071493	cellular response to UV-B	0.010759447034272888	0.010759447034272888	+1	STK11,CDKN1A
SEX DETERMINATION%GOBP%GO:0007530	sex determination	0.010759447034272888	0.010759447034272888	+1	SOX9,WT1
MAST CELL DEGRANULATION%GOBP%GO:0043303	mast cell degranulation	0.010759447034272888	0.010759447034272888	+1	PIK3CG,KIT
TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20240510%WP4211%HOMO SAPIENS	Transcriptional cascade regulating adipogenesis	0.010759447034272888	0.010759447034272888	+1	GATA3,CEBPA
IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 81%2428924	IGF1R signaling cascade	0.010759447034272888	0.010759447034272888	+1	PIK3CA,FLT3,PTPN11
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.2	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.010759447034272888	0.010759447034272888	+1	PIK3CA,PIK3CG
NEGATIVE REGULATION OF ORGANELLE ASSEMBLY%GOBP%GO:1902116	negative regulation of organelle assembly	0.010759447034272888	0.010759447034272888	+1	BRCA1,LRRK2,SMAD4
MITRAL VALVE DEVELOPMENT%GOBP%GO:0003174	mitral valve development	0.010759447034272888	0.010759447034272888	+1	NOTCH1,AXIN2
IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3	IRS-related events triggered by IGF1R	0.010759447034272888	0.010759447034272888	+1	PIK3CA,FLT3,PTPN11
REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION%GOBP%GO:1903747	regulation of establishment of protein localization to mitochondrion	0.010759447034272888	0.010759447034272888	+1	FBXW7,BAP1,LRRK2
POSITIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	0.010759447034272888	0.010759447034272888	+1	EGFR,CCND1
MAST CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE%GOBP%GO:0002279	mast cell activation involved in immune response	0.010759447034272888	0.010759447034272888	+1	PIK3CG,KIT
TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20240510%WP3859%HOMO SAPIENS	TGF beta signaling in thyroid cells for epithelial mesenchymal transition	0.010759447034272888	0.010759447034272888	+1	SMAD4,SMAD2
REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 81%1433617	Regulation of signaling by NODAL	0.010759447034272888	0.010759447034272888	+1	ACVR1B,ACVR2A
REGULATION OF EPITHELIAL CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:2000696	regulation of epithelial cell differentiation involved in kidney development	0.010759447034272888	0.010759447034272888	+1	GATA3,CTNNB1
PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20240510%WP2848%HOMO SAPIENS	Pluripotent stem cell differentiation pathway	0.010759447034272888	0.010759447034272888	+1	NOTCH1,HGF,KIT
POSITIVE REGULATION OF SMOOTH MUSCLE CELL DIFFERENTIATION%GOBP%GO:0051152	positive regulation of smooth muscle cell differentiation	0.010759447034272888	0.010759447034272888	+1	NOTCH1,KIT
LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS	LKB1 signaling events	0.010759447034272888	0.010759447034272888	+1	TP53,STK11,SMAD4
PHOSPHATIDYLINOSITOL-3-PHOSPHATE BIOSYNTHETIC PROCESS%GOBP%GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	0.010759447034272888	0.010759447034272888	+1	PIK3CA,PIK3CG
PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY	PID_FOXO_PATHWAY	0.010759447034272888	0.010759447034272888	+1	CTNNB1,CDKN1B,EP300
HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 81%5685939	HDR through MMEJ (alt-NHEJ)	0.010759447034272888	0.010759447034272888	+1	POLQ,BRCA2
REGULATION OF KERATINOCYTE MIGRATION%GOBP%GO:0051547	regulation of keratinocyte migration	0.010759447034272888	0.010759447034272888	+1	PTEN,EPPK1
MITOTIC SPINDLE ORGANIZATION%GOBP%GO:0007052	mitotic spindle organization	0.010802850381383698	0.010802850381383698	+1	STAG2,CHEK2,SMC1A,SMC3
CELLULAR RESPONSE TO TUMOR NECROSIS FACTOR%GOBP%GO:0071356	cellular response to tumor necrosis factor	0.010802850381383698	0.010802850381383698	+1	TP53,GATA3,NFE2L2,BRCA1
PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20240510%WP3998%HOMO SAPIENS	Prader Willi and Angelman syndrome	0.010802850381383698	0.010802850381383698	+1	CDKN2A,RB1,CCND1,CDKN2C
CONNECTIVE TISSUE DEVELOPMENT%GOBP%GO:0061448	connective tissue development	0.010802850381383698	0.010802850381383698	+1	RUNX1,SOX9,ARID5B,FGFR3
CELLULAR RESPONSE TO OXYGEN LEVELS%GOBP%GO:0071453	cellular response to oxygen levels	0.010802850381383698	0.010802850381383698	+1	TP53,VHL,NOTCH1,NFE2L2
REGULATION OF MYELOID CELL DIFFERENTIATION%GOBP%GO:0045637	regulation of myeloid cell differentiation	0.010869434817182671	0.010869434817182671	+1	FBXW7,RUNX1,TLR4,ACVR1B,ACVR2A
G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5	G2 M Checkpoints	0.011177918971454667	0.011177918971454667	+1	TP53,ATM,BRCA1,CHEK2,ATR
GLIAL CELL DIFFERENTIATION%GOBP%GO:0010001	glial cell differentiation	0.01121318845585738	0.01121318845585738	+1	PTEN,NF1,SOX9,PRX
CARDIAC CELL DEVELOPMENT%GOBP%GO:0055006	cardiac cell development	0.011310020165004282	0.011310020165004282	+1	NOTCH1,TBX3,PDGFRA
PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY	PID_AR_TF_PATHWAY	0.011310020165004282	0.011310020165004282	+1	MAP2K4,CEBPA,EP300
TRAIL%IOB%TRAIL	TRAIL	0.011310020165004282	0.011310020165004282	+1	CTNNB1,ATM,CHEK2
APPENDAGE MORPHOGENESIS%GOBP%GO:0035107	appendage morphogenesis	0.011310020165004282	0.011310020165004282	+1	CTNNB1,TBX3,FGFR2
EMBRYONIC HEART TUBE MORPHOGENESIS%GOBP%GO:0003143	embryonic heart tube morphogenesis	0.011310020165004282	0.011310020165004282	+1	NOTCH1,TGFBR2,SOX17
SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME DATABASE ID RELEASE 81%2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.011310020165004282	0.011310020165004282	+1	PIK3CA,FLT3,PTPN11
DETERMINATION OF HEART LEFT/RIGHT ASYMMETRY%GOBP%GO:0061371	determination of heart left/right asymmetry	0.011310020165004282	0.011310020165004282	+1	NOTCH1,TGFBR2,SOX17
LIMB MORPHOGENESIS%GOBP%GO:0035108	limb morphogenesis	0.011310020165004282	0.011310020165004282	+1	CTNNB1,TBX3,FGFR2
CARDIAC MUSCLE TISSUE MORPHOGENESIS%GOBP%GO:0055008	cardiac muscle tissue morphogenesis	0.011310020165004282	0.011310020165004282	+1	NOTCH1,FGFR2,SMAD4
APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006	Apoptosis signaling pathway	0.011556796225448532	0.011556796225448532	+1	TP53,PIK3CA,MAP2K4,PIK3CG
DNA REPLICATION%GOBP%GO:0006260	DNA replication	0.011702367746554353	0.011702367746554353	+1	ATRX,BRCA1,POLQ,BRCA2,ATR
PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY	PID_KIT_PATHWAY	0.011938913085449459	0.011938913085449459	+1	PTEN,KIT,PTPN11
LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 81%9024446	LXR-mediated signaling	0.011938913085449459	0.011938913085449459	+1	EP300,TBL1XR1,NCOR1
RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY	RhoA signaling pathway	0.011938913085449459	0.011938913085449459	+1	PTEN,MAP2K4,CDKN1B
MUSCLE ORGAN DEVELOPMENT%GOBP%GO:0007517	muscle organ development	0.011938913085449459	0.011938913085449459	+1	NOTCH1,WT1,FGFR2,SMAD4,EGR3
REGULATION OF AUTOPHAGOSOME ASSEMBLY%GOBP%GO:2000785	regulation of autophagosome assembly	0.011938913085449459	0.011938913085449459	+1	ATM,LRRK2,CHEK2
INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-HSA-74751.5	Insulin receptor signalling cascade	0.011938913085449459	0.011938913085449459	+1	PIK3CA,FLT3,PTPN11
A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING	a6b1 and a6b4 Integrin signaling	0.011938913085449459	0.011938913085449459	+1	PIK3CA,EGFR,CDH1
TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6	TGF-beta receptor signaling activates SMADs	0.011938913085449459	0.011938913085449459	+1	SMAD4,TGFBR2,SMAD2
CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS	Class I PI3K signaling events	0.011938913085449459	0.011938913085449459	+1	PIK3CA,PTEN,PIK3CG
INTERLEUKIN-6-MEDIATED SIGNALING PATHWAY%GOBP%GO:0070102	interleukin-6-mediated signaling pathway	0.01202238860850817	0.01202238860850817	+1	CEBPA,SMAD4
BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY	BIOCARTA_TEL_PATHWAY	0.01202238860850817	0.01202238860850817	+1	EGFR,RB1
AXONAL FASCICULATION%GOBP%GO:0007413	axonal fasciculation	0.01202238860850817	0.01202238860850817	+1	ARHGAP35,EPHA3
SIGNALING BY EGFRVIII IN CANCER%REACTOME DATABASE ID RELEASE 81%5637812	Signaling by EGFRvIII in Cancer	0.01202238860850817	0.01202238860850817	+1	PIK3CA,EGFR
TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20240510%WP3%HOMO SAPIENS	Transcriptional activation by NRF2 in response to phytochemicals	0.01202238860850817	0.01202238860850817	+1	KEAP1,NFE2L2
HEART VALVE FORMATION%GOBP%GO:0003188	heart valve formation	0.01202238860850817	0.01202238860850817	+1	NOTCH1,SMAD4
TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 81%8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.01202238860850817	0.01202238860850817	+1	EGFR,KIT
PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 81%1963642	PI3K events in ERBB2 signaling	0.01202238860850817	0.01202238860850817	+1	PIK3CA,EGFR
PERIPHERAL NERVOUS SYSTEM AXON ENSHEATHMENT%GOBP%GO:0032292	peripheral nervous system axon ensheathment	0.01202238860850817	0.01202238860850817	+1	NF1,PRX
MYELINATION IN PERIPHERAL NERVOUS SYSTEM%GOBP%GO:0022011	myelination in peripheral nervous system	0.01202238860850817	0.01202238860850817	+1	NF1,PRX
PI-3K CASCADE:FGFR3%REACTOME%R-HSA-5654710.4	PI-3K cascade:FGFR3	0.01202238860850817	0.01202238860850817	+1	PIK3CA,PTPN11
CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 81%5637810	Constitutive Signaling by EGFRvIII	0.01202238860850817	0.01202238860850817	+1	PIK3CA,EGFR
NEGATIVE REGULATION OF CARDIAC MUSCLE HYPERTROPHY%GOBP%GO:0010614	negative regulation of cardiac muscle hypertrophy	0.01202238860850817	0.01202238860850817	+1	NOTCH1,SMAD4
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 81%113501	Inhibition of replication initiation of damaged DNA by RB1 E2F1	0.01202238860850817	0.01202238860850817	+1	RB1,PPP2R1A
MAST CELL MEDIATED IMMUNITY%GOBP%GO:0002448	mast cell mediated immunity	0.01202238860850817	0.01202238860850817	+1	PIK3CG,KIT
PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY	PID_HIF1A_PATHWAY	0.01202238860850817	0.01202238860850817	+1	VHL,CDKN2A
NEURON PROJECTION FASCICULATION%GOBP%GO:0106030	neuron projection fasciculation	0.01202238860850817	0.01202238860850817	+1	ARHGAP35,EPHA3
NEGATIVE REGULATION OF MUSCLE HYPERTROPHY%GOBP%GO:0014741	negative regulation of muscle hypertrophy	0.01202238860850817	0.01202238860850817	+1	NOTCH1,SMAD4
SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20240510%WP4814%HOMO SAPIENS	Somatic sex determination	0.01202238860850817	0.01202238860850817	+1	SOX9,WT1
SCHWANN CELL DEVELOPMENT%GOBP%GO:0014044	Schwann cell development	0.01202238860850817	0.01202238860850817	+1	NF1,PRX
REGULATION OF PEPTIDYL-SERINE PHOSPHORYLATION%GOBP%GO:0033135	regulation of peptidyl-serine phosphorylation	0.012115901668694445	0.012115901668694445	+1	PTEN,EGFR,BRAF,NSD1
POSITIVE REGULATION OF MITOTIC CELL CYCLE%GOBP%GO:0045931	positive regulation of mitotic cell cycle	0.012115901668694445	0.012115901668694445	+1	EGFR,RB1,FOXA1,CCND1
ANTERIOR/POSTERIOR PATTERN SPECIFICATION%GOBP%GO:0009952	anterior/posterior pattern specification	0.012115901668694445	0.012115901668694445	+1	TBX3,WT1,FOXA2,SMAD2
POSITIVE REGULATION OF RECEPTOR SIGNALING PATHWAY VIA STAT%GOBP%GO:1904894	positive regulation of receptor signaling pathway via STAT	0.012390262944404687	0.012390262944404687	+1	NOTCH1,KIT,EP300
PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY	PID_TAP63_PATHWAY	0.012390262944404687	0.012390262944404687	+1	CDKN2A,EP300,CDKN1A
EPHRIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0048013	ephrin receptor signaling pathway	0.012390262944404687	0.012390262944404687	+1	EPHA3,EPHB6,PTPN11
REGULATION OF CD4-POSITIVE, ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation	0.012390262944404687	0.012390262944404687	+1	RUNX1,EP300,CBFB
BMP SIGNALING PATHWAY%GOBP%GO:0030509	BMP signaling pathway	0.012390262944404687	0.012390262944404687	+1	SMAD4,USP9X,ACVR2A
PEPTIDYL-SERINE MODIFICATION%GOBP%GO:0018209	peptidyl-serine modification	0.012496507385689748	0.012496507385689748	+1	ATM,LRRK2,TAF1,ATR
REGULATION OF MUSCLE CELL DIFFERENTIATION%GOBP%GO:0051147	regulation of muscle cell differentiation	0.012496507385689748	0.012496507385689748	+1	NOTCH1,KIT,FGFR2,SMAD4
SARS-COV-1-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 81%9692914	SARS-CoV-1-host interactions	0.012496507385689748	0.012496507385689748	+1	NPM1,RUNX1,EP300,SMAD4
REGULATORY NCRNA-MEDIATED GENE SILENCING%GOBP%GO:0031047	regulatory ncRNA-mediated gene silencing	0.01296547554192232	0.01296547554192232	+1	DNMT3A,AJUBA,SMAD2,EZH2
ARTERY DEVELOPMENT%GOBP%GO:0060840	artery development	0.01307964604796401	0.01307964604796401	+1	NF1,NOTCH1,TGFBR2
T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977	T Cell Receptor Signaling Pathway	0.01307964604796401	0.01307964604796401	+1	PIK3CA,MAP2K4,PIK3CG
IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS	IL6-mediated signaling events	0.01307964604796401	0.01307964604796401	+1	PIK3CA,MAP2K4,PTPN11
POSITIVE REGULATION OF CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:1902808	positive regulation of cell cycle G1/S phase transition	0.01307964604796401	0.01307964604796401	+1	EGFR,CCND1,EZH2
22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20240510%WP4657%HOMO SAPIENS	22q11 2 copy number variation syndrome	0.013385525850863014	0.013385525850863014	+1	EGFR,FGFR2,FOXA2,NCOR1
REGULATION OF TORC1 SIGNALING%GOBP%GO:1903432	regulation of TORC1 signaling	0.013385525850863014	0.013385525850863014	+1	VHL,STK11,ATM,EP300
REGULATION OF MICROTUBULE-BASED PROCESS%GOBP%GO:0032886	regulation of microtubule-based process	0.013408176885119381	0.013408176885119381	+1	APC,NAV3,NPM1,STK11,EPHA3,BRCA1
NODAL SIGNALING PATHWAY%GOBP%GO:0038092	nodal signaling pathway	0.013475197850882472	0.013475197850882472	+1	ACVR1B,SMAD2
ANIMAL ORGAN FORMATION%GOBP%GO:0048645	animal organ formation	0.013475197850882472	0.013475197850882472	+1	FGFR2,SOX17
AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.3	AXIN missense mutants destabilize the destruction complex	0.013475197850882472	0.013475197850882472	+1	APC,PPP2R1A
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 81%198323	AKT phosphorylates targets in the cytosol	0.013475197850882472	0.013475197850882472	+1	CDKN1B,CDKN1A
SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 81%4839744	Signaling by APC mutants	0.013475197850882472	0.013475197850882472	+1	APC,PPP2R1A
NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20240510%WP3413%HOMO SAPIENS	NOTCH1 regulation of endothelial cell calcification	0.013475197850882472	0.013475197850882472	+1	NOTCH1,FGFR3
QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20240510%WP2435%HOMO SAPIENS	Quercetin and Nf kB AP 1 induced apoptosis	0.013475197850882472	0.013475197850882472	+1	KEAP1,NFE2L2
POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION%GOBP%GO:0060045	positive regulation of cardiac muscle cell proliferation	0.013475197850882472	0.013475197850882472	+1	NOTCH1,FGFR2
TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.4	Truncations of AMER1 destabilize the destruction complex	0.013475197850882472	0.013475197850882472	+1	APC,PPP2R1A
MAST CELL ACTIVATION%GOBP%GO:0045576	mast cell activation	0.013475197850882472	0.013475197850882472	+1	PIK3CG,KIT
REGULATION OF RETINOIC ACID RECEPTOR SIGNALING PATHWAY%GOBP%GO:0048385	regulation of retinoic acid receptor signaling pathway	0.013475197850882472	0.013475197850882472	+1	ASXL1,EZH2
SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 81%4839735	Signaling by AXIN mutants	0.013475197850882472	0.013475197850882472	+1	APC,PPP2R1A
IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS	IL5-mediated signaling events	0.013475197850882472	0.013475197850882472	+1	PIK3CA,PTPN11
APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME DATABASE ID RELEASE 81%5467337	APC truncation mutants have impaired AXIN binding	0.013475197850882472	0.013475197850882472	+1	APC,PPP2R1A
BRANCHING INVOLVED IN BLOOD VESSEL MORPHOGENESIS%GOBP%GO:0001569	branching involved in blood vessel morphogenesis	0.013475197850882472	0.013475197850882472	+1	CTNNB1,TGFBR2
SIGNALING BY AMER1 MUTANTS%REACTOME DATABASE ID RELEASE 81%4839748	Signaling by AMER1 mutants	0.013475197850882472	0.013475197850882472	+1	APC,PPP2R1A
RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2	RUNX3 regulates NOTCH signaling	0.013475197850882472	0.013475197850882472	+1	NOTCH1,EP300
POSITIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN KINASE ACTIVITY%GOBP%GO:1904031	positive regulation of cyclin-dependent protein kinase activity	0.013475197850882472	0.013475197850882472	+1	EGFR,CCND1
RESPONSE TO UV-A%GOBP%GO:0070141	response to UV-A	0.013475197850882472	0.013475197850882472	+1	EGFR,CCND1
OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20240510%WP3971%HOMO SAPIENS	OSX and miRNAs in tooth development	0.013475197850882472	0.013475197850882472	+1	NOTCH1,CTNNB1
SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 81%9665348	Signaling by ERBB2 ECD mutants	0.013475197850882472	0.013475197850882472	+1	PIK3CA,EGFR
HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS	Hedgehog signaling events mediated by Gli proteins	0.013522208039841811	0.013522208039841811	+1	FOXA2,SIN3A,SPOP
REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION%GOBP%GO:2000177	regulation of neural precursor cell proliferation	0.013522208039841811	0.013522208039841811	+1	NF1,CTNNB1,LRRK2
ENDOCRINE SYSTEM DEVELOPMENT%GOBP%GO:0035270	endocrine system development	0.013522208039841811	0.013522208039841811	+1	NF1,WT1,FOXA2
THYROID STIMULATING HORMONE TSH SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP2032%HOMO SAPIENS	Thyroid stimulating hormone TSH signaling pathway	0.013522208039841811	0.013522208039841811	+1	RB1,BRAF,CDKN1B
SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3	Signaling by NOTCH3	0.013522208039841811	0.013522208039841811	+1	EGFR,NOTCH1,EP300
POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY	Posttranslational regulation of adherens junction stability and dissassembly	0.013522208039841811	0.013522208039841811	+1	EGFR,CTNNB1,CDH1
MYELOID LEUKOCYTE ACTIVATION%GOBP%GO:0002274	myeloid leukocyte activation	0.013522981052307988	0.013522981052307988	+1	PIK3CG,TLR4,KIT,TGFBR2
REGULATION OF CIRCADIAN RHYTHM%GOBP%GO:0042752	regulation of circadian rhythm	0.013522981052307988	0.013522981052307988	+1	TP53,FBXW7,USP9X,EZH2
TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.9	Toll-like Receptor Cascades	0.01395404297813478	0.01395404297813478	+1	TP53,MAP2K4,TLR4,PPP2R1A,PTPN11
TELOMERE ORGANIZATION%GOBP%GO:0032200	telomere organization	0.013975743992361848	0.013975743992361848	+1	ATM,ATRX,ATR,EZH2
TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.5	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation	0.013975743992361848	0.013975743992361848	+1	TP53,MAP2K4,TLR4,PPP2R1A
REGULATION OF CELL-MATRIX ADHESION%GOBP%GO:0001952	regulation of cell-matrix adhesion	0.013975743992361848	0.013975743992361848	+1	PTEN,NF1,CDKN2A,EPHA3
EMBRYONIC HEART TUBE DEVELOPMENT%GOBP%GO:0035050	embryonic heart tube development	0.01413979913489087	0.01413979913489087	+1	NOTCH1,TGFBR2,SOX17
WOUND HEALING%GOBP%GO:0042060	wound healing	0.01413979913489087	0.01413979913489087	+1	PIK3CA,NF1,ARHGAP35,EPPK1,PIK3CG,PDGFRA
SIGNALING BY PDGF%REACTOME%R-HSA-186797.6	Signaling by PDGF	0.01413979913489087	0.01413979913489087	+1	PIK3CA,PDGFRA,PTPN11
KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP304%HOMO SAPIENS	Kit receptor signaling pathway	0.01413979913489087	0.01413979913489087	+1	KIT,EP300,PTPN11
PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY	PID_SHP2_PATHWAY	0.01413979913489087	0.01413979913489087	+1	EGFR,ARHGAP35,PTPN11
EPITHELIAL TUBE FORMATION%GOBP%GO:0072175	epithelial tube formation	0.01413979913489087	0.01413979913489087	+1	GATA3,SOX9,FGFR2
NEGATIVE REGULATION OF TORC1 SIGNALING%GOBP%GO:1904262	negative regulation of TORC1 signaling	0.01413979913489087	0.01413979913489087	+1	VHL,STK11,ATM
HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20240510%WP2849%HOMO SAPIENS	Hematopoietic stem cell differentiation	0.01413979913489087	0.01413979913489087	+1	NOTCH1,RUNX1,ACVR1B
FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING	FoxO family signaling	0.01413979913489087	0.01413979913489087	+1	CTNNB1,CDKN1B,EP300
REGULATION OF CARBOHYDRATE CATABOLIC PROCESS%GOBP%GO:0043470	regulation of carbohydrate catabolic process	0.01413979913489087	0.01413979913489087	+1	TP53,EP300,NCOR1
HETEROCHROMATIN FORMATION%GOBP%GO:0031507	heterochromatin formation	0.014337946854558248	0.014337946854558248	+1	RB1,DNMT3A,ATRX,EZH2
MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 81%975155	MyD88 dependent cascade initiated on endosome	0.014337946854558248	0.014337946854558248	+1	TP53,MAP2K4,TLR4,PPP2R1A
NEGATIVE REGULATION OF CELL ADHESION%GOBP%GO:0007162	negative regulation of cell adhesion	0.014612594372078706	0.014612594372078706	+1	PTEN,CDKN2A,NOTCH1,CDH1,RUNX1,CBFB
TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.8	Toll Like Receptor 7 8 (TLR7 8) Cascade	0.014831943049536368	0.014831943049536368	+1	TP53,MAP2K4,TLR4,PPP2R1A
CELLULAR RESPONSE TO EXTERNAL STIMULUS%GOBP%GO:0071496	cellular response to external stimulus	0.014832522717260184	0.014832522717260184	+1	MAP2K4,SOX9,TLR4
DEVELOPMENTAL CELL GROWTH%GOBP%GO:0048588	developmental cell growth	0.014832522717260184	0.014832522717260184	+1	CTNNB1,SOX9,USP9X
MUSCLE ORGAN MORPHOGENESIS%GOBP%GO:0048644	muscle organ morphogenesis	0.014832522717260184	0.014832522717260184	+1	NOTCH1,FGFR2,SMAD4
CELLULAR RESPONSE TO MECHANICAL STIMULUS%GOBP%GO:0071260	cellular response to mechanical stimulus	0.014832522717260184	0.014832522717260184	+1	MAP2K4,SOX9,TLR4
ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING	Angiopoietin receptor Tie2-mediated signaling	0.014832522717260184	0.014832522717260184	+1	PIK3CA,CDKN1A,PTPN11
MUSCLE TISSUE MORPHOGENESIS%GOBP%GO:0060415	muscle tissue morphogenesis	0.014832522717260184	0.014832522717260184	+1	NOTCH1,FGFR2,SMAD4
POSITIVE REGULATION OF PROTEIN BINDING%GOBP%GO:0032092	positive regulation of protein binding	0.014832522717260184	0.014832522717260184	+1	LRRK2,USP9X,TAF1
EMBRYONIC HEMOPOIESIS%GOBP%GO:0035162	embryonic hemopoiesis	0.014854953147847407	0.014854953147847407	+1	KIT,TGFBR2
NEGATIVE REGULATION OF CD4-POSITIVE, ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	0.014854953147847407	0.014854953147847407	+1	RUNX1,CBFB
RESPONSE TO MUSCLE STRETCH%GOBP%GO:0035994	response to muscle stretch	0.014854953147847407	0.014854953147847407	+1	PIK3CA,CTNNB1
PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY	PID_BETA_CATENIN_DEG_PATHWAY	0.014854953147847407	0.014854953147847407	+1	CTNNB1,AXIN2
BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY	BIOCARTA_TID_PATHWAY	0.014854953147847407	0.014854953147847407	+1	RB1,WT1
SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 81%9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	0.014854953147847407	0.014854953147847407	+1	EP300,SMAD4
BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY	BIOCARTA_TOB1_PATHWAY	0.014854953147847407	0.014854953147847407	+1	SMAD4,TGFBR2
GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20240510%WP4970%HOMO SAPIENS	Galanin receptor pathway	0.014854953147847407	0.014854953147847407	+1	CDKN1B,CDKN1A
PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4	PI-3K cascade:FGFR1	0.014854953147847407	0.014854953147847407	+1	PIK3CA,PTPN11
BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY	BIOCARTA_PITX2_PATHWAY	0.014854953147847407	0.014854953147847407	+1	CTNNB1,EP300
POSITIVE REGULATION OF ANIMAL ORGAN MORPHOGENESIS%GOBP%GO:0110110	positive regulation of animal organ morphogenesis	0.014854953147847407	0.014854953147847407	+1	GATA3,SOX9
NEGATIVE REGULATION OF CHONDROCYTE DIFFERENTIATION%GOBP%GO:0032331	negative regulation of chondrocyte differentiation	0.014854953147847407	0.014854953147847407	+1	SOX9,PTPN11
FOXA2 PATHWAY%WIKIPATHWAYS_20240510%WP5066%HOMO SAPIENS	FOXA2 pathway	0.014854953147847407	0.014854953147847407	+1	FOXA1,FOXA2
HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20240510%WP4206%HOMO SAPIENS	Hereditary leiomyomatosis and renal cell carcinoma pathway	0.014854953147847407	0.014854953147847407	+1	KEAP1,NFE2L2
PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20240510%WP5342%HOMO SAPIENS	Pathophysiological roles of DUX4 in FSHD1	0.014854953147847407	0.014854953147847407	+1	EP300,CDKN1A
REGULATION OF CELL-SUBSTRATE ADHESION%GOBP%GO:0010810	regulation of cell-substrate adhesion	0.014965627429516388	0.014965627429516388	+1	PTEN,NF1,CDKN2A,NOTCH1,EPHA3
REGULATION OF PROTEIN UBIQUITINATION%GOBP%GO:0031396	regulation of protein ubiquitination	0.015341152239045546	0.015341152239045546	+1	PTEN,FBXW7,CTNNB1,LRRK2,TAF1
CELL GROWTH%GOBP%GO:0016049	cell growth	0.01542320347899745	0.01542320347899745	+1	CTNNB1,SOX9,USP9X
SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 81%177929	Signaling by EGFR	0.01542320347899745	0.01542320347899745	+1	PIK3CA,EGFR,PTPN11
APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 81%75153	Apoptotic execution phase	0.01542320347899745	0.01542320347899745	+1	APC,CTNNB1,CDH1
MRNA PROCESSING%WIKIPATHWAYS_20240510%WP411%HOMO SAPIENS	mRNA processing	0.015532132695036194	0.015532132695036194	+1	U2AF1,SF3B1,SMC1A,SPOP
SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 81%2467813	Separation of Sister Chromatids	0.016044121304007723	0.016044121304007723	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-HSA-168138.5	Toll Like Receptor 9 (TLR9) Cascade	0.016044121304007723	0.016044121304007723	+1	TP53,MAP2K4,TLR4,PPP2R1A
HCMV INFECTION%REACTOME DATABASE ID RELEASE 81%9609646	HCMV Infection	0.016044121304007723	0.016044121304007723	+1	EGFR,TBL1XR1,NCOR1,EZH2
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4	Transcriptional activation of mitochondrial biogenesis	0.016183764310454433	0.016183764310454433	+1	IDH2,TBL1XR1,NCOR1
DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20240510%WP5180%HOMO SAPIENS	DYRK1A involvement regarding cell proliferation in brain development	0.016183764310454433	0.016183764310454433	+1	NOTCH1,CDKN1B,CCND1
NEGATIVE REGULATION OF CELL-SUBSTRATE ADHESION%GOBP%GO:0010812	negative regulation of cell-substrate adhesion	0.016183764310454433	0.016183764310454433	+1	PTEN,CDKN2A,NOTCH1
POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN%GOBP%GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	0.016183764310454433	0.016183764310454433	+1	FLT3,KIT,FGFR3
MEIOTIC CELL CYCLE%GOBP%GO:0051321	meiotic cell cycle	0.01638274924264717	0.01638274924264717	+1	PTEN,ATM,SMC1A,SMC3,RAD21
NEGATIVE REGULATION OF CARTILAGE DEVELOPMENT%GOBP%GO:0061037	negative regulation of cartilage development	0.01654302586570557	0.01654302586570557	+1	SOX9,PTPN11
POSITIVE REGULATION OF DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	0.01654302586570557	0.01654302586570557	+1	ATM,ATR
RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20240510%WP4483%HOMO SAPIENS	Relationship between inflammation COX 2 and EGFR	0.01654302586570557	0.01654302586570557	+1	EGFR,BRAF
REGULATION OF EXTRACELLULAR MATRIX ASSEMBLY%GOBP%GO:1901201	regulation of extracellular matrix assembly	0.01654302586570557	0.01654302586570557	+1	NOTCH1,SMAD4
FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 81%2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.01654302586570557	0.01654302586570557	+1	TP53,RB1
POSITIVE REGULATION OF TRANSCRIPTION BY RNA POLYMERASE III%GOBP%GO:0045945	positive regulation of transcription by RNA polymerase III	0.01654302586570557	0.01654302586570557	+1	AR,SF3B1
REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 81%210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.01654302586570557	0.01654302586570557	+1	NOTCH1,EP300
SCHWANN CELL DIFFERENTIATION%GOBP%GO:0014037	Schwann cell differentiation	0.01654302586570557	0.01654302586570557	+1	NF1,PRX
REGULATION OF SMALL MOLECULE METABOLIC PROCESS%GOBP%GO:0062012	regulation of small molecule metabolic process	0.01654302586570557	0.01654302586570557	+1	TP53,SOX9,BRCA1,EP300,FOXA2,NCOR1
TIE2 SIGNALING%REACTOME%R-HSA-210993.3	Tie2 Signaling	0.01654302586570557	0.01654302586570557	+1	PIK3CA,PTPN11
FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 81%9614657	FOXO-mediated transcription of cell death genes	0.01654302586570557	0.01654302586570557	+1	STK11,EP300
BRAIN MORPHOGENESIS%GOBP%GO:0048854	brain morphogenesis	0.01654302586570557	0.01654302586570557	+1	PTEN,NF1
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-HSA-1660499.8	Synthesis of PIPs at the plasma membrane	0.016850867486552887	0.016850867486552887	+1	PIK3CA,PTEN,PIK3CG
ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN	Alpha6Beta4Integrin	0.016850867486552887	0.016850867486552887	+1	EGFR,PTPN11,SMAD2
MORPHOGENESIS OF EMBRYONIC EPITHELIUM%GOBP%GO:0016331	morphogenesis of embryonic epithelium	0.016850867486552887	0.016850867486552887	+1	GATA3,SOX9,FGFR2
CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20240510%WP3594%HOMO SAPIENS	Circadian rhythm genes	0.016988782072570097	0.016988782072570097	+1	PTEN,EP300,SIN3A,NCOR1,EZH2
NEDDYLATION%REACTOME%R-HSA-8951664.7	Neddylation	0.01708976573522066	0.01708976573522066	+1	VHL,FBXW7,KEAP1,NFE2L2,BRCA1,CDKN1A
REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS%GOBP%GO:0090287	regulation of cellular response to growth factor stimulus	0.017385767617025146	0.017385767617025146	+1	GATA3,NOTCH1,STK11,EP300,SMAD4,SMAD2
WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057	Wnt signaling pathway	0.017385767617025146	0.017385767617025146	+1	ARID1A,CTNNB1,CDH1,EP300,SMAD4,TBL1XR1
NEGATIVE REGULATION OF CELL MIGRATION%GOBP%GO:0030336	negative regulation of cell migration	0.017385767617025146	0.017385767617025146	+1	PTEN,NAV3,NF1,NOTCH1,CDH1,EPPK1
RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY	RAC1 signaling pathway	0.01757208208903523	0.01757208208903523	+1	CTNNB1,CDH1,MAP2K4
CARDIAC MUSCLE CELL DIFFERENTIATION%GOBP%GO:0055007	cardiac muscle cell differentiation	0.01757208208903523	0.01757208208903523	+1	TBX3,WT1,PDGFRA
MEIOTIC RECOMBINATION%REACTOME%R-HSA-912446.5	Meiotic recombination	0.01757208208903523	0.01757208208903523	+1	ATM,BRCA1,BRCA2
NUCLEOTIDE-EXCISION REPAIR%GOBP%GO:0006289	nucleotide-excision repair	0.01757208208903523	0.01757208208903523	+1	TP53,BRCA2,ERCC2
VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS	Validated transcriptional targets of TAp63 isoforms	0.01757208208903523	0.01757208208903523	+1	CDKN2A,EP300,CDKN1A
REGULATION OF VACUOLE ORGANIZATION%GOBP%GO:0044088	regulation of vacuole organization	0.01757208208903523	0.01757208208903523	+1	ATM,LRRK2,CHEK2
NEGATIVE REGULATION OF PROTEIN-CONTAINING COMPLEX DISASSEMBLY%GOBP%GO:0043242	negative regulation of protein-containing complex disassembly	0.01757208208903523	0.01757208208903523	+1	PIK3CA,APC,NAV3
SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 81%1236394	Signaling by ERBB4	0.01757208208903523	0.01757208208903523	+1	PIK3CA,EGFR,NCOR1
IMMUNE RESPONSE-REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0002768	immune response-regulating cell surface receptor signaling pathway	0.017944058357297343	0.017944058357297343	+1	PIK3CA,GATA3,MAP2K4,TLR4,KIT,EP300
ANGIOGENESIS%WIKIPATHWAYS_20240510%WP1539%HOMO SAPIENS	Angiogenesis	0.01807272864078637	0.01807272864078637	+1	PDGFRA,FGFR2
SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5	Signaling by KIT in disease	0.01807272864078637	0.01807272864078637	+1	PIK3CA,KIT
REGULATION OF EPITHELIAL CELL DIFFERENTIATION%GOBP%GO:0030856	regulation of epithelial cell differentiation	0.01807272864078637	0.01807272864078637	+1	GATA3,CTNNB1,SOX9,VEZF1
TRIPARTITE REGIONAL SUBDIVISION%GOBP%GO:0007351	tripartite regional subdivision	0.01807272864078637	0.01807272864078637	+1	TBX3,WT1
RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20240510%WP3303%HOMO SAPIENS	RAC1 PAK1 p38 MMP2 pathway	0.01807272864078637	0.01807272864078637	+1	EGFR,CTNNB1,PTPN11
NEGATIVE REGULATION OF ANOIKIS%GOBP%GO:2000811	negative regulation of anoikis	0.01807272864078637	0.01807272864078637	+1	PIK3CA,NOTCH1
PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY	PID_VEGFR1_2_PATHWAY	0.01807272864078637	0.01807272864078637	+1	CTNNB1,BRAF,PTPN11
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 81%8941858	Regulation of RUNX3 expression and activity	0.01807272864078637	0.01807272864078637	+1	CDKN2A,EP300,CBFB
SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 81%9703465	Signaling by FLT3 fusion proteins	0.01807272864078637	0.01807272864078637	+1	PIK3CA,CDKN1A
INTRACELLULAR ESTROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0030520	intracellular estrogen receptor signaling pathway	0.01807272864078637	0.01807272864078637	+1	ARID1A,AR
UROGENITAL SYSTEM DEVELOPMENT%GOBP%GO:0001655	urogenital system development	0.01807272864078637	0.01807272864078637	+1	SOX9,FGFR2
CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 81%1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.01807272864078637	0.01807272864078637	+1	PIK3CA,EGFR
ANTERIOR/POSTERIOR AXIS SPECIFICATION, EMBRYO%GOBP%GO:0008595	anterior/posterior axis specification, embryo	0.01807272864078637	0.01807272864078637	+1	TBX3,WT1
ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6	Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	0.01807272864078637	0.01807272864078637	+1	TLR4,PTPN11
BLASTODERM SEGMENTATION%GOBP%GO:0007350	blastoderm segmentation	0.01807272864078637	0.01807272864078637	+1	TBX3,WT1
BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY	BIOCARTA_MTOR_PATHWAY	0.01807272864078637	0.01807272864078637	+1	PTEN,EIF4A2
NEPHRON EPITHELIUM DEVELOPMENT%GOBP%GO:0072009	nephron epithelium development	0.01807272864078637	0.01807272864078637	+1	GATA3,SOX9,WT1
SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 81%5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.01807272864078637	0.01807272864078637	+1	PIK3CA,EGFR
POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE GROWTH%GOBP%GO:0055023	positive regulation of cardiac muscle tissue growth	0.01807272864078637	0.01807272864078637	+1	NOTCH1,FGFR2
CELLULAR RESPONSE TO ALCOHOL%GOBP%GO:0097306	cellular response to alcohol	0.01807272864078637	0.01807272864078637	+1	CTNNB1,CDH1,BRCA1
SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	0.01807272864078637	0.01807272864078637	+1	PIK3CA,KIT
PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.4	Platelet sensitization by LDL	0.01807272864078637	0.01807272864078637	+1	PPP2R1A,PTPN11
REGULATORY NCRNA-MEDIATED HETEROCHROMATIN FORMATION%GOBP%GO:0031048	regulatory ncRNA-mediated heterochromatin formation	0.01807272864078637	0.01807272864078637	+1	DNMT3A,EZH2
RESPONSE TO UV-B%GOBP%GO:0010224	response to UV-B	0.01807272864078637	0.01807272864078637	+1	STK11,CDKN1A
RESPONSE TO TUMOR NECROSIS FACTOR%GOBP%GO:0034612	response to tumor necrosis factor	0.01807272864078637	0.01807272864078637	+1	TP53,GATA3,NFE2L2,BRCA1
PI-3K CASCADE:FGFR4%REACTOME%R-HSA-5654720.4	PI-3K cascade:FGFR4	0.01807272864078637	0.01807272864078637	+1	PIK3CA,PTPN11
SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 81%5655332	Signaling by FGFR3 in disease	0.01807272864078637	0.01807272864078637	+1	PIK3CA,FGFR3
BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY	BIOCARTA_GSK3_PATHWAY	0.01807272864078637	0.01807272864078637	+1	CTNNB1,CCND1
MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-166058.5	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.018518738954889057	0.018518738954889057	+1	TP53,MAP2K4,TLR4,PPP2R1A
TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.3	Toll Like Receptor TLR1:TLR2 Cascade	0.018518738954889057	0.018518738954889057	+1	TP53,MAP2K4,TLR4,PPP2R1A
TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3	Toll Like Receptor 2 (TLR2) Cascade	0.018518738954889057	0.018518738954889057	+1	TP53,MAP2K4,TLR4,PPP2R1A
CELLULAR RESPONSE TO NUTRIENT LEVELS%GOBP%GO:0031669	cellular response to nutrient levels	0.018518738954889057	0.018518738954889057	+1	TP53,LRRK2,EP300,FOXA2,CDKN1A
TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3	Toll Like Receptor TLR6:TLR2 Cascade	0.018518738954889057	0.018518738954889057	+1	TP53,MAP2K4,TLR4,PPP2R1A
GLIAL CELL DEVELOPMENT%GOBP%GO:0021782	glial cell development	0.018873164525954837	0.018873164525954837	+1	PTEN,NF1,PRX
PKR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 81%9833482	PKR-mediated signaling	0.018873164525954837	0.018873164525954837	+1	TP53,NPM1,PPP2R1A
LEUKOCYTE PROLIFERATION%GOBP%GO:0070661	leukocyte proliferation	0.018873164525954837	0.018873164525954837	+1	FLT3,PIK3CG,KIT
REGULATION OF SMAD PROTEIN SIGNAL TRANSDUCTION%GOBP%GO:0060390	regulation of SMAD protein signal transduction	0.018873164525954837	0.018873164525954837	+1	SMAD4,TGFBR2,ACVR2A
REGULATION OF WOUND HEALING%GOBP%GO:0061041	regulation of wound healing	0.019043288288212515	0.019043288288212515	+1	PTEN,EPPK1,PDGFRA,FOXA2
SMAD PROTEIN SIGNAL TRANSDUCTION%GOBP%GO:0060395	SMAD protein signal transduction	0.019327586425603546	0.019327586425603546	+1	SMAD4,SMAD2
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-HSA-5654708.3	Downstream signaling of activated FGFR3	0.019327586425603546	0.019327586425603546	+1	PIK3CA,PTPN11
HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 81%5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.019327586425603546	0.019327586425603546	+1	ATM,BRCA1,BRCA2,ATR
REGULATION OF MITOTIC SISTER CHROMATID SEPARATION%GOBP%GO:0010965	regulation of mitotic sister chromatid separation	0.019327586425603546	0.019327586425603546	+1	APC,RB1,ATM
REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING	Regulation of cytoplasmic and nuclear SMAD2 3 signaling	0.019327586425603546	0.019327586425603546	+1	SMAD4,SMAD2
MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 81%68877	Mitotic Prometaphase	0.019327586425603546	0.019327586425603546	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
RORA ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-1368082.5	RORA activates gene expression	0.019327586425603546	0.019327586425603546	+1	EP300,TBL1XR1
G2 M TRANSITION%REACTOME DATABASE ID RELEASE 81%69275	G2 M Transition	0.019327586425603546	0.019327586425603546	+1	TP53,AJUBA,EP300,CDKN1A,PPP2R1A
SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 81%3232118	SUMOylation of transcription factors	0.019327586425603546	0.019327586425603546	+1	TP53,CDKN2A
SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7	Signaling by FGFR in disease	0.019327586425603546	0.019327586425603546	+1	PIK3CA,FGFR2,FGFR3
MITOTIC G2-G2 M PHASES%REACTOME%R-HSA-453274.4	Mitotic G2-G2 M phases	0.019327586425603546	0.019327586425603546	+1	TP53,AJUBA,EP300,CDKN1A,PPP2R1A
SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4	Signaling by PDGFR in disease	0.019327586425603546	0.019327586425603546	+1	PIK3CA,PDGFRA
ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME%R-HSA-9819196.1	Zygotic genome activation (ZGA)	0.019327586425603546	0.019327586425603546	+1	TP53,EP300
GLIOGENESIS%GOBP%GO:0042063	gliogenesis	0.019327586425603546	0.019327586425603546	+1	PTEN,NF1,SOX9,PRX
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.019327586425603546	0.019327586425603546	+1	TP53,EP300
NEGATIVE REGULATION OF FIBROBLAST PROLIFERATION%GOBP%GO:0048147	negative regulation of fibroblast proliferation	0.019327586425603546	0.019327586425603546	+1	TP53,NF1
REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME%R-HSA-400206.8	Regulation of lipid metabolism by PPARalpha	0.019327586425603546	0.019327586425603546	+1	EP300,SIN3A,TBL1XR1,NCOR1
FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 81%201722	Formation of the beta-catenin:TCF transactivating complex	0.019327586425603546	0.019327586425603546	+1	CTNNB1,EP300,AXIN2
BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597	Bafetinib Inhibition of BCR-ABL	0.019327586425603546	0.019327586425603546	+1	TP53,CDKN1B
BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596	Bosutinib Inhibition of BCR-ABL	0.019327586425603546	0.019327586425603546	+1	TP53,CDKN1B
NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595	Nilotinib Inhibition of BCR-ABL	0.019327586425603546	0.019327586425603546	+1	TP53,CDKN1B
DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594	Dasatinib Inhibition of BCR-ABL	0.019327586425603546	0.019327586425603546	+1	TP53,CDKN1B
ENDOTHELIAL CELL DIFFERENTIATION%GOBP%GO:0045446	endothelial cell differentiation	0.019327586425603546	0.019327586425603546	+1	NOTCH1,SMAD4,SOX17
BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692	BCR-ABL Action in CML Pathogenesis	0.019327586425603546	0.019327586425603546	+1	TP53,CDKN1B
PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598	Ponatinib Inhibition of BCR-ABL	0.019327586425603546	0.019327586425603546	+1	TP53,CDKN1B
NEGATIVE REGULATION OF WOUND HEALING%GOBP%GO:0061045	negative regulation of wound healing	0.019327586425603546	0.019327586425603546	+1	PTEN,EPPK1,PDGFRA
REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 81%8943724	Regulation of PTEN gene transcription	0.019327586425603546	0.019327586425603546	+1	TP53,MECOM,EZH2
NEGATIVE REGULATION OF GLIOGENESIS%GOBP%GO:0014014	negative regulation of gliogenesis	0.019327586425603546	0.019327586425603546	+1	NF1,NOTCH1
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME DATABASE ID RELEASE 81%8876384	Listeria monocytogenes entry into host cells	0.019327586425603546	0.019327586425603546	+1	CTNNB1,CDH1
NUCLEOSOME ASSEMBLY%GOBP%GO:0006334	nucleosome assembly	0.019327586425603546	0.019327586425603546	+1	NPM1,SOX9,ATRX
ANDROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0030521	androgen receptor signaling pathway	0.019327586425603546	0.019327586425603546	+1	ARID1A,AR
NEGATIVE REGULATION OF NUCLEOTIDE METABOLIC PROCESS%GOBP%GO:0045980	negative regulation of nucleotide metabolic process	0.019327586425603546	0.019327586425603546	+1	TP53,NCOR1
PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20240510%WP5103%HOMO SAPIENS	Progeria associated lipodystrophy	0.019327586425603546	0.019327586425603546	+1	SMAD4,SMAD2
REGULATION OF DNA DAMAGE CHECKPOINT%GOBP%GO:2000001	regulation of DNA damage checkpoint	0.019327586425603546	0.019327586425603546	+1	BRCA1,BRCA2
BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY	BIOCARTA_ARENRF2_PATHWAY	0.019327586425603546	0.019327586425603546	+1	KEAP1,NFE2L2
MYELINATION%GOBP%GO:0042552	myelination	0.019327586425603546	0.019327586425603546	+1	PTEN,NF1,PRX
PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY	PID_HDAC_CLASSI_PATHWAY	0.019327586425603546	0.019327586425603546	+1	EP300,SIN3A,NCOR1
POSITIVE REGULATION OF MACROPHAGE ACTIVATION%GOBP%GO:0043032	positive regulation of macrophage activation	0.019327586425603546	0.019327586425603546	+1	CEBPA,TLR4
POSITIVE REGULATION OF WNT SIGNALING PATHWAY%GOBP%GO:0030177	positive regulation of Wnt signaling pathway	0.019327586425603546	0.019327586425603546	+1	EGFR,LRRK2,FGFR2,TBL1XR1
MAINTENANCE OF GASTROINTESTINAL EPITHELIUM%GOBP%GO:0030277	maintenance of gastrointestinal epithelium	0.019327586425603546	0.019327586425603546	+1	SOX9,TLR4
REGULATION OF OLIGODENDROCYTE DIFFERENTIATION%GOBP%GO:0048713	regulation of oligodendrocyte differentiation	0.019327586425603546	0.019327586425603546	+1	NF1,NOTCH1
CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20240510%WP5417%HOMO SAPIENS	Cell lineage map for neuronal differentiation	0.019327586425603546	0.019327586425603546	+1	NOTCH1,SOX9,FOXA2,SOX17
ENDOCHONDRAL BONE MORPHOGENESIS%GOBP%GO:0060350	endochondral bone morphogenesis	0.019327586425603546	0.019327586425603546	+1	SOX9,FGFR3
REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN%GOBP%GO:0042509	regulation of tyrosine phosphorylation of STAT protein	0.019327586425603546	0.019327586425603546	+1	FLT3,KIT,FGFR3
CELL CHEMOTAXIS%GOBP%GO:0060326	cell chemotaxis	0.019327586425603546	0.019327586425603546	+1	PIK3CG,HGF,KIT,PDGFRA,EGR3
EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING	EPHA2 forward signaling	0.019327586425603546	0.019327586425603546	+1	PIK3CA,ARHGAP35
CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS%GOBP%GO:0021955	central nervous system neuron axonogenesis	0.019327586425603546	0.019327586425603546	+1	PTEN,ARHGAP35
NEGATIVE REGULATION OF PURINE NUCLEOTIDE METABOLIC PROCESS%GOBP%GO:1900543	negative regulation of purine nucleotide metabolic process	0.019327586425603546	0.019327586425603546	+1	TP53,NCOR1
CELL FATE DETERMINATION%GOBP%GO:0001709	cell fate determination	0.019327586425603546	0.019327586425603546	+1	GATA3,SOX17
POSITIVE REGULATION OF REPRODUCTIVE PROCESS%GOBP%GO:2000243	positive regulation of reproductive process	0.019327586425603546	0.019327586425603546	+1	SOX9,WT1,ACVR1B
PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 81%5654695	PI-3K cascade:FGFR2	0.019327586425603546	0.019327586425603546	+1	PIK3CA,PTPN11
RESPIRATORY SYSTEM DEVELOPMENT%GOBP%GO:0060541	respiratory system development	0.019327586425603546	0.019327586425603546	+1	CEBPA,WT1,FGFR2
PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY	PID_CDC42_PATHWAY	0.019327586425603546	0.019327586425603546	+1	CTNNB1,MAP2K4,BRAF
VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING PATHWAY%GOBP%GO:0038084	vascular endothelial growth factor signaling pathway	0.019327586425603546	0.019327586425603546	+1	PIK3CA,PDGFRA
NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3	NFE2L2 regulating anti-oxidant detoxification enzymes	0.019327586425603546	0.019327586425603546	+1	NFE2L2,EP300
HOMOLOGOUS RECOMBINATION%GOBP%GO:0035825	homologous recombination	0.019759585302971346	0.019759585302971346	+1	ATM,BRCA1,RAD21
KITRECEPTOR%IOB%KITRECEPTOR	KitReceptor	0.019759585302971346	0.019759585302971346	+1	KIT,EP300,PTPN11
T CELL ACTIVATION%PANTHER PATHWAY%P00053	T cell activation	0.019759585302971346	0.019759585302971346	+1	PIK3CA,BRAF,PIK3CG
NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 81%198725	Nuclear Events (kinase and transcription factor activation)	0.019759585302971346	0.019759585302971346	+1	EP300,PPP2R1A,EGR3
SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 81%187577	SCF(Skp2)-mediated degradation of p27 p21	0.019759585302971346	0.019759585302971346	+1	CDKN1B,CCND1,CDKN1A
DOUBLE-STRAND BREAK REPAIR VIA HOMOLOGOUS RECOMBINATION%GOBP%GO:0000724	double-strand break repair via homologous recombination	0.019784834057318307	0.019784834057318307	+1	ATM,BRCA1,BRCA2,RAD21
VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056	VEGF signaling pathway	0.020574482380065685	0.020574482380065685	+1	PIK3CA,BRAF,PIK3CG
ENSHEATHMENT OF NEURONS%GOBP%GO:0007272	ensheathment of neurons	0.020574482380065685	0.020574482380065685	+1	PTEN,NF1,PRX
AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20240510%WP5356%HOMO SAPIENS	Affected pathways in Duchenne muscular dystrophy	0.020574482380065685	0.020574482380065685	+1	SMAD4,TGFBR2,SMAD2
AXON ENSHEATHMENT%GOBP%GO:0008366	axon ensheathment	0.020574482380065685	0.020574482380065685	+1	PTEN,NF1,PRX
NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING	Neurotrophic factor-mediated Trk receptor signaling	0.020574482380065685	0.020574482380065685	+1	PIK3CA,CCND1,PTPN11
TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20240510%WP5130%HOMO SAPIENS	Th17 cell differentiation pathway	0.020574482380065685	0.020574482380065685	+1	GATA3,RUNX1,SMAD2
NEGATIVE REGULATION OF NEUROGENESIS%GOBP%GO:0050768	negative regulation of neurogenesis	0.020574482380065685	0.020574482380065685	+1	PTEN,NF1,NOTCH1
ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20240510%WP2858%HOMO SAPIENS	Ectoderm differentiation	0.020874872770660424	0.020874872770660424	+1	CTNNB1,FGFR2,SMAD4,FOXA2
INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20240510%WP4559%HOMO SAPIENS	Interactions between immune cells and microRNAs in tumor microenvironment	0.020913594630148316	0.020913594630148316	+1	TLR4,TGFBR2
KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20240510%WP5044%HOMO SAPIENS	Kynurenine pathway and links to cell senescence	0.020913594630148316	0.020913594630148316	+1	TLR4,CDKN1A
NEGATIVE REGULATION OF ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0046639	negative regulation of alpha-beta T cell differentiation	0.020913594630148316	0.020913594630148316	+1	RUNX1,CBFB
REGULATION OF RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1902882	regulation of response to oxidative stress	0.020913594630148316	0.020913594630148316	+1	KEAP1,NFE2L2
CTLA4 INHIBITORY SIGNALING%REACTOME%R-HSA-389513.4	CTLA4 inhibitory signaling	0.020913594630148316	0.020913594630148316	+1	PPP2R1A,PTPN11
INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE BY P53 CLASS MEDIATOR%GOBP%GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	0.020913594630148316	0.020913594630148316	+1	TP53,EP300
PULMONARY VALVE MORPHOGENESIS%GOBP%GO:0003184	pulmonary valve morphogenesis	0.020913594630148316	0.020913594630148316	+1	NOTCH1,SMAD2
BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY	BIOCARTA_EIF4_PATHWAY	0.020913594630148316	0.020913594630148316	+1	PTEN,EIF4A2
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2	NOTCH4 Intracellular Domain Regulates Transcription	0.020913594630148316	0.020913594630148316	+1	NOTCH1,EP300
BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY	BIOCARTA_HER2_PATHWAY	0.020913594630148316	0.020913594630148316	+1	EGFR,EP300
POSITIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING%GOBP%GO:2000679	positive regulation of transcription regulatory region DNA binding	0.020913594630148316	0.020913594630148316	+1	GATA3,RB1
STEM CELL PROLIFERATION%GOBP%GO:0072089	stem cell proliferation	0.020913594630148316	0.020913594630148316	+1	RUNX1,MECOM
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.020913594630148316	0.020913594630148316	+1	TP53,ATM
POSITIVE REGULATION OF UBIQUITIN-PROTEIN TRANSFERASE ACTIVITY%GOBP%GO:0051443	positive regulation of ubiquitin-protein transferase activity	0.020913594630148316	0.020913594630148316	+1	PTEN,FBXW7
NRF2 ARE REGULATION%WIKIPATHWAYS_20240510%WP4357%HOMO SAPIENS	NRF2 ARE regulation	0.020913594630148316	0.020913594630148316	+1	KEAP1,NFE2L2
CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY	Canonical Wnt signaling pathway	0.020913594630148316	0.020913594630148316	+1	APC,CTNNB1
EMBRYONIC DIGESTIVE TRACT DEVELOPMENT%GOBP%GO:0048566	embryonic digestive tract development	0.020913594630148316	0.020913594630148316	+1	PDGFRA,FGFR2
RESPONSE TO CHOLESTEROL%GOBP%GO:0070723	response to cholesterol	0.020913594630148316	0.020913594630148316	+1	TGFBR2,SMAD2
REGULATION OF JNK CASCADE%GOBP%GO:0046328	regulation of JNK cascade	0.021176240053197657	0.021176240053197657	+1	EGFR,MAPK8IP1,MECOM,NCOR1
FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS	Fc-epsilon receptor I signaling in mast cells	0.021176240053197657	0.021176240053197657	+1	PIK3CA,MAP2K4,PTPN11
REGULATION OF PROTEIN DEPOLYMERIZATION%GOBP%GO:1901879	regulation of protein depolymerization	0.021176240053197657	0.021176240053197657	+1	PIK3CA,APC,NAV3
REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY%GOBP%GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.021176240053197657	0.021176240053197657	+1	STK11,EP300,SMAD4,SMAD2
PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY	PID_AVB3_INTEGRIN_PATHWAY	0.021176240053197657	0.021176240053197657	+1	CDKN1B,TGFBR2,PTPN11
REGULATION OF PROTEIN BINDING%GOBP%GO:0043393	regulation of protein binding	0.021764410395796338	0.021764410395796338	+1	LRRK2,USP9X,CDKN1A,TAF1
INNER EAR DEVELOPMENT%GOBP%GO:0048839	inner ear development	0.02208967762596969	0.02208967762596969	+1	SOX9,FGFR2,PTPN11
16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20240510%WP4949%HOMO SAPIENS	16p11 2 proximal deletion syndrome	0.02208967762596969	0.02208967762596969	+1	PTEN,MLL2,PPP2R1A
RECOMBINATIONAL REPAIR%GOBP%GO:0000725	recombinational repair	0.02233482181709834	0.02233482181709834	+1	ATM,BRCA1,BRCA2,RAD21
REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS%GOBP%GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	0.02233482181709834	0.02233482181709834	+1	STK11,EP300,SMAD4,SMAD2
NEGATIVE REGULATION OF HIPPO SIGNALING%GOBP%GO:0035331	negative regulation of hippo signaling	0.022654492667512002	0.022654492667512002	+1	AJUBA,PPP2R1A
POSITIVE REGULATION OF LEUKOCYTE APOPTOTIC PROCESS%GOBP%GO:2000108	positive regulation of leukocyte apoptotic process	0.022654492667512002	0.022654492667512002	+1	TP53,CDKN2A
BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY	BIOCARTA_TFF_PATHWAY	0.022654492667512002	0.022654492667512002	+1	EGFR,CTNNB1
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.022654492667512002	0.022654492667512002	+1	TP53,NPM1
PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY	PID_MYC_PATHWAY	0.022654492667512002	0.022654492667512002	+1	CDKN2A,FBXW7
NEGATIVE REGULATION OF MICROTUBULE DEPOLYMERIZATION%GOBP%GO:0007026	negative regulation of microtubule depolymerization	0.022654492667512002	0.022654492667512002	+1	APC,NAV3
IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694	Imatinib Inhibition of BCR-ABL	0.022654492667512002	0.022654492667512002	+1	TP53,CDKN1B
SIGNALING BY NTRK2 (TRKB)%REACTOME%R-HSA-9006115.3	Signaling by NTRK2 (TRKB)	0.022654492667512002	0.022654492667512002	+1	PIK3CA,PTPN11
URETERIC BUD MORPHOGENESIS%GOBP%GO:0060675	ureteric bud morphogenesis	0.022654492667512002	0.022654492667512002	+1	GATA3,WT1
PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY	PDGFR-alpha signaling pathway	0.022654492667512002	0.022654492667512002	+1	PIK3CA,PDGFRA
SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3	Signaling by ERBB2 KD Mutants	0.022654492667512002	0.022654492667512002	+1	PIK3CA,EGFR
PROTEIN LOCALIZATION TO CHROMOSOME, CENTROMERIC REGION%GOBP%GO:0071459	protein localization to chromosome, centromeric region	0.022654492667512002	0.022654492667512002	+1	RB1,CTCF
CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0060317	cardiac epithelial to mesenchymal transition	0.022654492667512002	0.022654492667512002	+1	NOTCH1,TBX3
SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS	Syndecan-3-mediated signaling events	0.022654492667512002	0.022654492667512002	+1	EGFR,FGFR3
NEGATIVE REGULATION OF EPITHELIAL CELL MIGRATION%GOBP%GO:0010633	negative regulation of epithelial cell migration	0.022796383410287873	0.022796383410287873	+1	PTEN,NOTCH1,EPPK1
SIGNALING BY MET%REACTOME DATABASE ID RELEASE 81%6806834	Signaling by MET	0.022796383410287873	0.022796383410287873	+1	PIK3CA,HGF,PTPN11
NEGATIVE REGULATION OF SUPRAMOLECULAR FIBER ORGANIZATION%GOBP%GO:1902904	negative regulation of supramolecular fiber organization	0.023362413860988213	0.023362413860988213	+1	PIK3CA,APC,NAV3,SMAD4
LIMB DEVELOPMENT%GOBP%GO:0060173	limb development	0.02374390210311276	0.02374390210311276	+1	CTNNB1,TBX3,FGFR2
APPENDAGE DEVELOPMENT%GOBP%GO:0048736	appendage development	0.02374390210311276	0.02374390210311276	+1	CTNNB1,TBX3,FGFR2
RESPONSE TO METAL ION%GOBP%GO:0010038	response to metal ion	0.023891476041419592	0.023891476041419592	+1	EGFR,CDH1,BRAF,CDKN1B,LRRK2
EGF EGFR SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP437%HOMO SAPIENS	EGF EGFR signaling pathway	0.023956171441185104	0.023956171441185104	+1	PTEN,EGFR,BRAF,PTPN11
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-HSA-5654716.3	Downstream signaling of activated FGFR4	0.024360004490080096	0.024360004490080096	+1	PIK3CA,PTPN11
SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 81%1227990	Signaling by ERBB2 in Cancer	0.024360004490080096	0.024360004490080096	+1	PIK3CA,EGFR
MIDBRAIN DEVELOPMENT%GOBP%GO:0030901	midbrain development	0.024360004490080096	0.024360004490080096	+1	CTNNB1,FGFR2,TAF1
ENDOCARDIAL CUSHION FORMATION%GOBP%GO:0003272	endocardial cushion formation	0.024360004490080096	0.024360004490080096	+1	NOTCH1,TBX3
REGULATION OF ACTIVIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0032925	regulation of activin receptor signaling pathway	0.024360004490080096	0.024360004490080096	+1	ACVR1B,ACVR2A
PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20240510%WP3612%HOMO SAPIENS	Photodynamic therapy induced NFE2L2 NRF2 survival signaling	0.024360004490080096	0.024360004490080096	+1	KEAP1,NFE2L2
HAIR CELL DIFFERENTIATION%GOBP%GO:0035315	hair cell differentiation	0.024360004490080096	0.024360004490080096	+1	CTNNB1,ERCC2
CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 81%400253	Circadian Clock	0.024360004490080096	0.024360004490080096	+1	EP300,TBL1XR1,NCOR1
BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY	BIOCARTA_PDGF_PATHWAY	0.024360004490080096	0.024360004490080096	+1	MAP2K4,PDGFRA
INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033	Insulin IGF pathway-protein kinase B signaling cascade	0.024360004490080096	0.024360004490080096	+1	PIK3CA,PTEN
SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20240510%WP5121%HOMO SAPIENS	Sphingolipid metabolism in senescence	0.024360004490080096	0.024360004490080096	+1	RB1,CDKN1A
BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY	BIOCARTA_EGF_PATHWAY	0.024360004490080096	0.024360004490080096	+1	EGFR,MAP2K4
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4	Transcriptional regulation of pluripotent stem cells	0.024360004490080096	0.024360004490080096	+1	SMAD4,SMAD2
AMEBOIDAL-TYPE CELL MIGRATION%GOBP%GO:0001667	ameboidal-type cell migration	0.024360004490080096	0.024360004490080096	+1	PIK3CA,KIT,SMAD4,EGR3
PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463	Phosphatidylinositol Phosphate Metabolism	0.024360004490080096	0.024360004490080096	+1	PTEN,EGFR
NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT%GOBP%GO:0051961	negative regulation of nervous system development	0.024360004490080096	0.024360004490080096	+1	PTEN,NF1,NOTCH1
JOUBERT SYNDROME%SMPDB%SMP0000582	Joubert Syndrome	0.024360004490080096	0.024360004490080096	+1	PTEN,EGFR
HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK	HIF-1-alpha transcription factor network	0.024360004490080096	0.024360004490080096	+1	NPM1,EP300,SMAD4
POSITIVE REGULATION OF INTERFERON-ALPHA PRODUCTION%GOBP%GO:0032727	positive regulation of interferon-alpha production	0.024360004490080096	0.024360004490080096	+1	TLR4,SETD2
BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2	Bacterial Infection Pathways	0.024360004490080096	0.024360004490080096	+1	CTNNB1,CDH1,MAP2K4
SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I	Signaling events mediated by HDAC Class I	0.024360004490080096	0.024360004490080096	+1	EP300,SIN3A,NCOR1
E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5	E2F mediated regulation of DNA replication	0.024360004490080096	0.024360004490080096	+1	RB1,PPP2R1A
REGULATION OF ANOIKIS%GOBP%GO:2000209	regulation of anoikis	0.024360004490080096	0.024360004490080096	+1	PIK3CA,NOTCH1
REGULATION OF FATTY ACID METABOLIC PROCESS%GOBP%GO:0019217	regulation of fatty acid metabolic process	0.025353318045568545	0.025353318045568545	+1	SOX9,BRCA1,NCOR1
NEGATIVE REGULATION OF TOR SIGNALING%GOBP%GO:0032007	negative regulation of TOR signaling	0.025353318045568545	0.025353318045568545	+1	VHL,STK11,ATM
ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.7	Antiviral mechanism by IFN-stimulated genes	0.025556699210612523	0.025556699210612523	+1	TP53,NPM1,PPP2R1A,EIF4A2
DENDRITIC CELL DIFFERENTIATION%GOBP%GO:0097028	dendritic cell differentiation	0.02611907660887812	0.02611907660887812	+1	FLT3,TGFBR2
POSITIVE REGULATION OF BMP SIGNALING PATHWAY%GOBP%GO:0030513	positive regulation of BMP signaling pathway	0.02611907660887812	0.02611907660887812	+1	NOTCH1,SMAD2
SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.3	Signaling by EGFR in Cancer	0.02611907660887812	0.02611907660887812	+1	PIK3CA,EGFR
BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY	BIOCARTA_ERK_PATHWAY	0.02611907660887812	0.02611907660887812	+1	EGFR,PDGFRA
BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY	BIOCARTA_AT1R_PATHWAY	0.02611907660887812	0.02611907660887812	+1	EGFR,MAP2K4
POSITIVE REGULATION OF TYPE I INTERFERON PRODUCTION%GOBP%GO:0032481	positive regulation of type I interferon production	0.02611907660887812	0.02611907660887812	+1	TLR4,SETD2,PTPN11
SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5	Signaling by Erythropoietin	0.02611907660887812	0.02611907660887812	+1	PIK3CA,PIK3CG
RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 81%9820960	Respiratory syncytial virus (RSV) attachment and entry	0.02611907660887812	0.02611907660887812	+1	EGFR,TLR4
NEGATIVE REGULATION OF OSTEOCLAST DIFFERENTIATION%GOBP%GO:0045671	negative regulation of osteoclast differentiation	0.02611907660887812	0.02611907660887812	+1	FBXW7,TLR4
MYOBLAST DIFFERENTIATION%GOBP%GO:0045445	myoblast differentiation	0.02611907660887812	0.02611907660887812	+1	RB1,NOTCH1
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 81%5654696	Downstream signaling of activated FGFR2	0.02611907660887812	0.02611907660887812	+1	PIK3CA,PTPN11
SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371	superpathway of inositol phosphate compounds	0.02611907660887812	0.02611907660887812	+1	PIK3CA,PTEN,PIK3CG
PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY	PID_GLYPICAN_1PATHWAY	0.02611907660887812	0.02611907660887812	+1	TGFBR2,SMAD2
CELLULAR RESPONSE TO INTERLEUKIN-6%GOBP%GO:0071354	cellular response to interleukin-6	0.02611907660887812	0.02611907660887812	+1	CEBPA,SMAD4
CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION%GOBP%GO:0021953	central nervous system neuron differentiation	0.02611907660887812	0.02611907660887812	+1	PTEN,ARHGAP35,FGFR2
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 81%5654687	Downstream signaling of activated FGFR1	0.02611907660887812	0.02611907660887812	+1	PIK3CA,PTPN11
PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY	PID_REG_GR_PATHWAY	0.02611907660887812	0.02611907660887812	+1	GATA3,EP300,CDKN1A
PHOSPHATIDYLINOSITOL-MEDIATED SIGNALING%GOBP%GO:0048015	phosphatidylinositol-mediated signaling	0.02611907660887812	0.02611907660887812	+1	PIK3CA,PIK3CG
NEGATIVE REGULATION OF CD4-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	0.02611907660887812	0.02611907660887812	+1	RUNX1,CBFB
CARTILAGE DEVELOPMENT%GOBP%GO:0051216	cartilage development	0.02611907660887812	0.02611907660887812	+1	RUNX1,SOX9,FGFR3
REGULATION OF CENTRIOLE REPLICATION%GOBP%GO:0046599	regulation of centriole replication	0.02611907660887812	0.02611907660887812	+1	NPM1,BRCA1
MESONEPHRIC TUBULE MORPHOGENESIS%GOBP%GO:0072171	mesonephric tubule morphogenesis	0.02611907660887812	0.02611907660887812	+1	GATA3,WT1
FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5	Formation of paraxial mesoderm	0.02705739469792632	0.02705739469792632	+1	NOTCH1,CTNNB1,EP300
REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL%GOBP%GO:1903320	regulation of protein modification by small protein conjugation or removal	0.0271934831402602	0.0271934831402602	+1	PTEN,FBXW7,CTNNB1,LRRK2,TAF1
SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20240510%WP706%HOMO SAPIENS	Sudden infant death syndrome SIDS susceptibility pathways	0.0271934831402602	0.0271934831402602	+1	GATA3,CTNNB1,CTCF,EP300
REGULATION OF RESPONSE TO WOUNDING%GOBP%GO:1903034	regulation of response to wounding	0.0271934831402602	0.0271934831402602	+1	PTEN,EPPK1,PDGFRA,FOXA2
REGULATION OF CARBOHYDRATE METABOLIC PROCESS%GOBP%GO:0006109	regulation of carbohydrate metabolic process	0.0271934831402602	0.0271934831402602	+1	TP53,EP300,FOXA2,NCOR1
SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20240510%WP5381%HOMO SAPIENS	Smith Magenis and Potocki Lupski syndrome copy number variation	0.02789177889176027	0.02789177889176027	+1	PTEN,TLR4,FOXA1,FOXA2
POSITIVE REGULATION OF CELL CYCLE G2/M PHASE TRANSITION%GOBP%GO:1902751	positive regulation of cell cycle G2/M phase transition	0.02800124239445213	0.02800124239445213	+1	NPM1,CCND1
LEPTIN%IOB%LEPTIN	Leptin	0.02800124239445213	0.02800124239445213	+1	EGFR,PTPN11
NEGATIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT%GOBP%GO:0070168	negative regulation of biomineral tissue development	0.02800124239445213	0.02800124239445213	+1	NOTCH1,SOX9
LEUKOCYTE DEGRANULATION%GOBP%GO:0043299	leukocyte degranulation	0.02800124239445213	0.02800124239445213	+1	PIK3CG,KIT
INTERLEUKIN-6 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 81%6783589	Interleukin-6 family signaling	0.02800124239445213	0.02800124239445213	+1	PTPN11,LIFR
RAS SIGNALING PATHWAY%SMPDB%SMP0063784	Ras Signaling Pathway	0.02800124239445213	0.02800124239445213	+1	PIK3CA,SMAD4
POSITIVE REGULATION OF MITOTIC CELL CYCLE PHASE TRANSITION%GOBP%GO:1901992	positive regulation of mitotic cell cycle phase transition	0.02800124239445213	0.02800124239445213	+1	EGFR,RB1,CCND1
FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20240510%WP5102%HOMO SAPIENS	Familial partial lipodystrophy	0.02800124239445213	0.02800124239445213	+1	GATA3,CEBPA
PULMONARY VALVE DEVELOPMENT%GOBP%GO:0003177	pulmonary valve development	0.02800124239445213	0.02800124239445213	+1	NOTCH1,SMAD2
BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY	BIOCARTA_FAS_PATHWAY	0.02800124239445213	0.02800124239445213	+1	RB1,MAP2K4
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2	NOTCH3 Intracellular Domain Regulates Transcription	0.02800124239445213	0.02800124239445213	+1	NOTCH1,EP300
DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 81%9734009	Defective Intrinsic Pathway for Apoptosis	0.02800124239445213	0.02800124239445213	+1	TP53,CDKN2A
POSITIVE REGULATION OF SIGNALING RECEPTOR ACTIVITY%GOBP%GO:2000273	positive regulation of signaling receptor activity	0.02800124239445213	0.02800124239445213	+1	FBXW7,TAF1
PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY	PID_HDAC_CLASSIII_PATHWAY	0.02800124239445213	0.02800124239445213	+1	EP300,CDKN1A
REGULATION OF PROTEIN TARGETING%GOBP%GO:1903533	regulation of protein targeting	0.02800124239445213	0.02800124239445213	+1	FBXW7,BAP1,LRRK2
POSITIVE REGULATION OF DNA REPAIR%GOBP%GO:0045739	positive regulation of DNA repair	0.02831333085114114	0.02831333085114114	+1	ARID1A,PBRM1,EGFR,BRCA1
MITOTIC SISTER CHROMATID SEGREGATION%GOBP%GO:0000070	mitotic sister chromatid segregation	0.02831333085114114	0.02831333085114114	+1	STAG2,CHEK2,SMC1A,SMC3
REGULATION OF PURINE NUCLEOTIDE METABOLIC PROCESS%GOBP%GO:1900542	regulation of purine nucleotide metabolic process	0.02877184546412084	0.02877184546412084	+1	TP53,EP300,NCOR1
EXTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:0097191	extrinsic apoptotic signaling pathway	0.02877184546412084	0.02877184546412084	+1	SMAD4,FGFR3,ACVR1B
POSITIVE REGULATION OF TOR SIGNALING%GOBP%GO:0032008	positive regulation of TOR signaling	0.02877184546412084	0.02877184546412084	+1	PIK3CA,EP300,USP9X
REGULATION OF CHROMOSOME SEPARATION%GOBP%GO:1905818	regulation of chromosome separation	0.02877184546412084	0.02877184546412084	+1	APC,RB1,ATM
REGULATION OF POST-TRANSLATIONAL PROTEIN MODIFICATION%GOBP%GO:1901873	regulation of post-translational protein modification	0.02893182522493591	0.02893182522493591	+1	PTEN,FBXW7,CTNNB1,LRRK2,TAF1
REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001242	regulation of intrinsic apoptotic signaling pathway	0.028936113562686314	0.028936113562686314	+1	TP53,FBXW7,NFE2L2,LRRK2
POSITIVE REGULATION OF MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:1905332	positive regulation of morphogenesis of an epithelium	0.029767476101339233	0.029767476101339233	+1	GATA3,SOX9
HALLMARK_NOTCH_SIGNALING%MSIGDBHALLMARK%HALLMARK_NOTCH_SIGNALING	HALLMARK_NOTCH_SIGNALING	0.029767476101339233	0.029767476101339233	+1	NOTCH1,CCND1
BONE MINERALIZATION%GOBP%GO:0030282	bone mineralization	0.029767476101339233	0.029767476101339233	+1	FGFR2,FGFR3
PI3K AKT MTOR SIGNALING PATHWAY AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20240510%WP3844%HOMO SAPIENS	PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer	0.029767476101339233	0.029767476101339233	+1	PTEN,CDKN1B
NEGATIVE REGULATION OF MIRNA TRANSCRIPTION%GOBP%GO:1902894	negative regulation of miRNA transcription	0.029767476101339233	0.029767476101339233	+1	SOX9,NCOR1
EPITHELIAL STRUCTURE MAINTENANCE%GOBP%GO:0010669	epithelial structure maintenance	0.029767476101339233	0.029767476101339233	+1	SOX9,TLR4
VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM	VEGFR3 signaling in lymphatic endothelium	0.029767476101339233	0.029767476101339233	+1	PIK3CA,MAP2K4
EPO%IOB%EPO	EPO	0.029767476101339233	0.029767476101339233	+1	BRAF,PTPN11
REGULATION OF MICROTUBULE DEPOLYMERIZATION%GOBP%GO:0031114	regulation of microtubule depolymerization	0.029767476101339233	0.029767476101339233	+1	APC,NAV3
REGULATION OF INTRACELLULAR ESTROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033146	regulation of intracellular estrogen receptor signaling pathway	0.029767476101339233	0.029767476101339233	+1	BRCA1,FOXA1
TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY	TRAIL signaling pathway	0.029767476101339233	0.029767476101339233	+1	PIK3CA,MAP2K4
REGULATION OF NUCLEOTIDE METABOLIC PROCESS%GOBP%GO:0006140	regulation of nucleotide metabolic process	0.029767476101339233	0.029767476101339233	+1	TP53,EP300,NCOR1
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 81%5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.029767476101339233	0.029767476101339233	+1	CDKN1B,CDKN1A
NEGATIVE REGULATION OF MACROAUTOPHAGY%GOBP%GO:0016242	negative regulation of macroautophagy	0.029767476101339233	0.029767476101339233	+1	PIK3CA,LRRK2
AMYLOID FIBRIL FORMATION%GOBP%GO:1990000	amyloid fibril formation	0.029767476101339233	0.029767476101339233	+1	VHL,USP9X
DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-HSA-2173788.3	Downregulation of TGF-beta receptor signaling	0.029767476101339233	0.029767476101339233	+1	TGFBR2,SMAD2
C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY	C-MYC pathway	0.029767476101339233	0.029767476101339233	+1	CDKN2A,FBXW7
COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 81%388841	Costimulation by the CD28 family	0.029767476101339233	0.029767476101339233	+1	PIK3CA,PPP2R1A,PTPN11
PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY	PID_AURORA_A_PATHWAY	0.029767476101339233	0.029767476101339233	+1	AJUBA,BRCA1
HAIR FOLLICLE DEVELOPMENT%GOBP%GO:0001942	hair follicle development	0.029767476101339233	0.029767476101339233	+1	SOX9,FGFR2
RESPONSE TO STEROL%GOBP%GO:0036314	response to sterol	0.029767476101339233	0.029767476101339233	+1	TGFBR2,SMAD2
NEGATIVE REGULATION OF RESPONSE TO WOUNDING%GOBP%GO:1903035	negative regulation of response to wounding	0.030528329657703454	0.030528329657703454	+1	PTEN,EPPK1,PDGFRA
FORMATION OF PRIMARY GERM LAYER%GOBP%GO:0001704	formation of primary germ layer	0.030528329657703454	0.030528329657703454	+1	SETD2,SOX17,SMAD2
SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.4	Signaling by Insulin receptor	0.030528329657703454	0.030528329657703454	+1	PIK3CA,FLT3,PTPN11
NEGATIVE REGULATION OF DNA-BINDING TRANSCRIPTION FACTOR ACTIVITY%GOBP%GO:0043433	negative regulation of DNA-binding transcription factor activity	0.030696610909730176	0.030696610909730176	+1	CDKN2A,RB1,KEAP1,FOXA2
PTEN REGULATION%REACTOME DATABASE ID RELEASE 81%6807070	PTEN Regulation	0.030696610909730176	0.030696610909730176	+1	TP53,PTEN,MECOM,EZH2
POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION%GOBP%GO:0050679	positive regulation of epithelial cell proliferation	0.031442935946556644	0.031442935946556644	+1	EGFR,SOX9,FGFR2,EGR3
REGULATION OF DNA BINDING%GOBP%GO:0051101	regulation of DNA binding	0.03155730124955485	0.03155730124955485	+1	GATA3,RB1,NSD1
MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20240510%WP1544%HOMO SAPIENS	MicroRNAs in cardiomyocyte hypertrophy	0.03155730124955485	0.03155730124955485	+1	CTNNB1,MAP2K4,FGFR2
CORTICOTROPIN RELEASING HORMONE SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP2355%HOMO SAPIENS	Corticotropin releasing hormone signaling pathway	0.03155730124955485	0.03155730124955485	+1	CTNNB1,BRAF,TLR4
NEGATIVE REGULATION OF MIRNA METABOLIC PROCESS%GOBP%GO:2000629	negative regulation of miRNA metabolic process	0.031820673343023666	0.031820673343023666	+1	SOX9,NCOR1
BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY	BIOCARTA_TNFR1_PATHWAY	0.031820673343023666	0.031820673343023666	+1	RB1,MAP2K4
PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20240510%WP5122%HOMO SAPIENS	Prostaglandin and leukotriene metabolism in senescence	0.031820673343023666	0.031820673343023666	+1	RB1,CDKN1A
EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING	Ephrin B reverse signaling	0.031820673343023666	0.031820673343023666	+1	PIK3CA,MAP2K4
GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK	Glypican 1 network	0.031820673343023666	0.031820673343023666	+1	TGFBR2,SMAD2
EGF SIGNALLING PATHWAY%SMPDB%SMP0063810	EGF Signalling Pathway	0.031820673343023666	0.031820673343023666	+1	EGFR,MAP2K4
IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS	IL3-mediated signaling events	0.03213006310678617	0.03213006310678617	+1	PIK3CA,PTPN11
3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352	3-phosphoinositide biosynthesis	0.03213006310678617	0.03213006310678617	+1	PIK3CA,PIK3CG
NEGATIVE REGULATION OF ENDOTHELIAL CELL APOPTOTIC PROCESS%GOBP%GO:2000352	negative regulation of endothelial cell apoptotic process	0.03213006310678617	0.03213006310678617	+1	GATA3,NFE2L2
HAIR CYCLE PROCESS%GOBP%GO:0022405	hair cycle process	0.03213006310678617	0.03213006310678617	+1	SOX9,FGFR2
VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS	VEGFR1 specific signals	0.03213006310678617	0.03213006310678617	+1	PIK3CA,PTPN11
ER-NUCLEUS SIGNALING PATHWAY%GOBP%GO:0006984	ER-nucleus signaling pathway	0.03213006310678617	0.03213006310678617	+1	TP53,NFE2L2
REGULATION OF INTERFERON-ALPHA PRODUCTION%GOBP%GO:0032647	regulation of interferon-alpha production	0.03213006310678617	0.03213006310678617	+1	TLR4,SETD2
CARDIOGENESIS%REACTOME DATABASE ID RELEASE 81%9733709	Cardiogenesis	0.03213006310678617	0.03213006310678617	+1	CTNNB1,SMAD4
REGULATION OF TRANSCRIPTION BY RNA POLYMERASE III%GOBP%GO:0006359	regulation of transcription by RNA polymerase III	0.03213006310678617	0.03213006310678617	+1	AR,SF3B1
REGULATION OF KERATINOCYTE PROLIFERATION%GOBP%GO:0010837	regulation of keratinocyte proliferation	0.03213006310678617	0.03213006310678617	+1	EPPK1,FGFR2
POSITIVE REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:1901798	positive regulation of signal transduction by p53 class mediator	0.03213006310678617	0.03213006310678617	+1	ATM,ATR
REGULATION OF NUCLEOTIDE-EXCISION REPAIR%GOBP%GO:2000819	regulation of nucleotide-excision repair	0.03213006310678617	0.03213006310678617	+1	ARID1A,PBRM1
MONONUCLEAR CELL DIFFERENTIATION%GOBP%GO:1903131	mononuclear cell differentiation	0.03213006310678617	0.03213006310678617	+1	GATA3,FLT3,ATM,KIT,TGFBR2
MOLTING CYCLE PROCESS%GOBP%GO:0022404	molting cycle process	0.03213006310678617	0.03213006310678617	+1	SOX9,FGFR2
OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20240510%WP5094%HOMO SAPIENS	Orexin receptor pathway	0.03213006310678617	0.03213006310678617	+1	VHL,NFE2L2,PTPN11
POSITIVE REGULATION OF ERYTHROCYTE DIFFERENTIATION%GOBP%GO:0045648	positive regulation of erythrocyte differentiation	0.03213006310678617	0.03213006310678617	+1	ACVR1B,ACVR2A
REGULATION OF INTRACELLULAR TRANSPORT%GOBP%GO:0032386	regulation of intracellular transport	0.03213006310678617	0.03213006310678617	+1	CDH1,STK11,LRRK2,SETD2,EP300
SPINDLE ASSEMBLY CHECKPOINT SIGNALING%GOBP%GO:0071173	spindle assembly checkpoint signaling	0.03213006310678617	0.03213006310678617	+1	APC,ATM
CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-HSA-1234174.5	Cellular response to hypoxia	0.03213006310678617	0.03213006310678617	+1	VHL,AJUBA,EP300
MITOTIC SPINDLE ASSEMBLY CHECKPOINT SIGNALING%GOBP%GO:0007094	mitotic spindle assembly checkpoint signaling	0.03213006310678617	0.03213006310678617	+1	APC,ATM
NEGATIVE REGULATION OF OSSIFICATION%GOBP%GO:0030279	negative regulation of ossification	0.03213006310678617	0.03213006310678617	+1	NOTCH1,SOX9
NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20240510%WP5366%HOMO SAPIENS	NF1 copy number variation syndrome	0.03213006310678617	0.03213006310678617	+1	EGFR,NF1,ATR
MITOTIC SPINDLE CHECKPOINT SIGNALING%GOBP%GO:0071174	mitotic spindle checkpoint signaling	0.03213006310678617	0.03213006310678617	+1	APC,ATM
ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20240510%WP5113%HOMO SAPIENS	Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway	0.03213006310678617	0.03213006310678617	+1	KEAP1,NFE2L2
PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20240510%WP5321%HOMO SAPIENS	Prostaglandin and leukotriene metabolism in senescence	0.03213006310678617	0.03213006310678617	+1	RB1,CDKN1A
REGULATION OF ALPHA-BETA T CELL PROLIFERATION%GOBP%GO:0046640	regulation of alpha-beta T cell proliferation	0.03213006310678617	0.03213006310678617	+1	TGFBR2,MAPK8IP1
CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.8	Cell-Cell communication	0.03214903374628781	0.03214903374628781	+1	PIK3CA,CTNNB1,CDH1,PTPN11
REGULATION OF PROTEIN LOCALIZATION TO MEMBRANE%GOBP%GO:1905475	regulation of protein localization to membrane	0.03214903374628781	0.03214903374628781	+1	PIK3CA,EGFR,EPHA3,AR
POSITIVE REGULATION OF DEVELOPMENTAL GROWTH%GOBP%GO:0048639	positive regulation of developmental growth	0.032657555556567915	0.032657555556567915	+1	NOTCH1,WT1,FGFR2
PROTEIN-DNA COMPLEX ASSEMBLY%GOBP%GO:0065004	protein-DNA complex assembly	0.032860356866778524	0.032860356866778524	+1	NPM1,SOX9,ATRX,TAF1
CAMERA-TYPE EYE DEVELOPMENT%GOBP%GO:0043010	camera-type eye development	0.032860356866778524	0.032860356866778524	+1	NF1,SOX9,WT1,PDGFRA
REGULATION OF CHONDROCYTE DIFFERENTIATION%GOBP%GO:0032330	regulation of chondrocyte differentiation	0.034114027064013945	0.034114027064013945	+1	SOX9,PTPN11
PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY	PID_HIF2PATHWAY	0.034114027064013945	0.034114027064013945	+1	VHL,EP300
NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE	Nephrin Neph1 signaling in the kidney podocyte	0.034114027064013945	0.034114027064013945	+1	PIK3CA,MAP2K4
SPINDLE CHECKPOINT SIGNALING%GOBP%GO:0031577	spindle checkpoint signaling	0.034114027064013945	0.034114027064013945	+1	APC,ATM
PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY	PID_IFNG_PATHWAY	0.034114027064013945	0.034114027064013945	+1	EP300,PTPN11
REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT%GOBP%GO:0046822	regulation of nucleocytoplasmic transport	0.03478710175655474	0.03478710175655474	+1	CDH1,SETD2,EP300
PLATELET ACTIVATION%GOBP%GO:0030168	platelet activation	0.03478710175655474	0.03478710175655474	+1	PIK3CA,PIK3CG,PDGFRA
POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION%GOBP%GO:0045639	positive regulation of myeloid cell differentiation	0.03478710175655474	0.03478710175655474	+1	RUNX1,ACVR1B,ACVR2A
NEGATIVE REGULATION OF CELL ACTIVATION%GOBP%GO:0050866	negative regulation of cell activation	0.03585839049794403	0.03585839049794403	+1	RUNX1,ATM,PDGFRA,CBFB
PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4	Processing of DNA double-strand break ends	0.0359382711567535	0.0359382711567535	+1	ATM,BRCA1,ATR
REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY	Reelin signaling pathway	0.03616148693963167	0.03616148693963167	+1	PIK3CA,MAPK8IP1
NEGATIVE REGULATION OF MITOTIC SISTER CHROMATID SEPARATION%GOBP%GO:2000816	negative regulation of mitotic sister chromatid separation	0.03616148693963167	0.03616148693963167	+1	APC,ATM
PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY	PID_ECADHERIN_NASCENT_AJ_PATHWAY	0.03616148693963167	0.03616148693963167	+1	CTNNB1,CCND1
NEGATIVE REGULATION OF MITOTIC SISTER CHROMATID SEGREGATION%GOBP%GO:0033048	negative regulation of mitotic sister chromatid segregation	0.03616148693963167	0.03616148693963167	+1	APC,ATM
NEGATIVE REGULATION OF MITOTIC METAPHASE/ANAPHASE TRANSITION%GOBP%GO:0045841	negative regulation of mitotic metaphase/anaphase transition	0.03616148693963167	0.03616148693963167	+1	APC,ATM
WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20240510%WP4149%HOMO SAPIENS	White fat cell differentiation	0.03616148693963167	0.03616148693963167	+1	GATA3,CEBPA
GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20240510%WP2363%HOMO SAPIENS	Gastric cancer network 2	0.03616148693963167	0.03616148693963167	+1	EGFR,CTNNB1
PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY	PID_NCADHERIN_PATHWAY	0.03616148693963167	0.03616148693963167	+1	CTNNB1,PTPN11
NEGATIVE REGULATION OF SISTER CHROMATID SEGREGATION%GOBP%GO:0033046	negative regulation of sister chromatid segregation	0.03616148693963167	0.03616148693963167	+1	APC,ATM
REGULATION OF ANDROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0060765	regulation of androgen receptor signaling pathway	0.03616148693963167	0.03616148693963167	+1	EP300,NCOR1
POSITIVE REGULATION OF PROTEIN IMPORT INTO NUCLEUS%GOBP%GO:0042307	positive regulation of protein import into nucleus	0.03616148693963167	0.03616148693963167	+1	CDH1,EP300
MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 81%68882	Mitotic Anaphase	0.03684540828911212	0.03684540828911212	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
IMMUNE SYSTEM DEVELOPMENT%GOBP%GO:0002520	immune system development	0.036879547708887475	0.036879547708887475	+1	TP53,GATA3,POLQ
MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 81%2555396	Mitotic Metaphase and Anaphase	0.037444629422222056	0.037444629422222056	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
MITOTIC NUCLEAR DIVISION%GOBP%GO:0140014	mitotic nuclear division	0.037989342217310415	0.037989342217310415	+1	STAG2,CHEK2,SMC1A,SMC3
NEGATIVE REGULATION OF CELL-CELL ADHESION%GOBP%GO:0022408	negative regulation of cell-cell adhesion	0.037989342217310415	0.037989342217310415	+1	NOTCH1,CDH1,RUNX1,CBFB
P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20240510%WP4963%HOMO SAPIENS	p53 transcriptional gene network	0.03802141718341889	0.03802141718341889	+1	PTEN,NOTCH1,CDKN1A
NEGATIVE REGULATION OF DNA BIOSYNTHETIC PROCESS%GOBP%GO:2000279	negative regulation of DNA biosynthetic process	0.03809140635128652	0.03809140635128652	+1	TP53,CDKN1A
TRANSCRIPTION ELONGATION BY RNA POLYMERASE II%GOBP%GO:0006368	transcription elongation by RNA polymerase II	0.03809140635128652	0.03809140635128652	+1	PBRM1,SETD2
IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY	IGF1 pathway	0.03809140635128652	0.03809140635128652	+1	PIK3CA,PTPN11
IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5	IL2 signaling events mediated by STAT5	0.03809140635128652	0.03809140635128652	+1	PIK3CA,PTPN11
FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20240510%WP3850%HOMO SAPIENS	Factors and pathways affecting insulin like growth factor IGF1 Akt signaling	0.03809140635128652	0.03809140635128652	+1	PTEN,SMAD2
MESODERM MORPHOGENESIS%GOBP%GO:0048332	mesoderm morphogenesis	0.03809140635128652	0.03809140635128652	+1	TBX3,SMAD2
MAPK CASCADE%WIKIPATHWAYS_20240510%WP422%HOMO SAPIENS	MAPK cascade	0.03809140635128652	0.03809140635128652	+1	MAP2K4,BRAF
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	0.03809140635128652	0.03809140635128652	+1	EGFR,PTPN11
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5	Regulation of TP53 Activity through Acetylation	0.03809140635128652	0.03809140635128652	+1	TP53,EP300
FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709	FAS signaling pathway ( CD95 )	0.03809140635128652	0.03809140635128652	+1	RB1,MAP2K4
PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY	PID_ARF6_PATHWAY	0.03809140635128652	0.03809140635128652	+1	EGFR,HGF
PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY	PID_PI3KCI_AKT_PATHWAY	0.03809140635128652	0.03809140635128652	+1	CDKN1B,CDKN1A
POSITIVE REGULATION OF FIBROBLAST PROLIFERATION%GOBP%GO:0048146	positive regulation of fibroblast proliferation	0.03809140635128652	0.03809140635128652	+1	PDGFRA,CDKN1A
SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME DATABASE ID RELEASE 81%9680350	Signaling by CSF1 (M-CSF) in myeloid cells	0.03809140635128652	0.03809140635128652	+1	PIK3CA,PTPN11
AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009	Axon guidance mediated by netrin	0.03809140635128652	0.03809140635128652	+1	PIK3CA,PIK3CG
OLIGODENDROCYTE DIFFERENTIATION%GOBP%GO:0048709	oligodendrocyte differentiation	0.03809140635128652	0.03809140635128652	+1	PTEN,SOX9
METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 81%5689901	Metalloprotease DUBs	0.03809140635128652	0.03809140635128652	+1	BRCA1,EP300
REGULATION OF BIOMINERAL TISSUE DEVELOPMENT%GOBP%GO:0070167	regulation of biomineral tissue development	0.038853731621370985	0.038853731621370985	+1	NOTCH1,SOX9,ACVR2A
DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4	Degradation of beta-catenin by the destruction complex	0.038853731621370985	0.038853731621370985	+1	APC,CTNNB1,PPP2R1A
PI METABOLISM%REACTOME%R-HSA-1483255.7	PI Metabolism	0.04005125912346011	0.04005125912346011	+1	PIK3CA,PTEN,PIK3CG
CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS	CXCR4-mediated signaling events	0.04005125912346011	0.04005125912346011	+1	PIK3CA,PIK3CG,PTPN11
POSITIVE REGULATION OF GROWTH%GOBP%GO:0045927	positive regulation of growth	0.04005125912346011	0.04005125912346011	+1	EGFR,NOTCH1,WT1,FGFR2
REGULATION OF CARDIAC MUSCLE HYPERTROPHY%GOBP%GO:0010611	regulation of cardiac muscle hypertrophy	0.040193593280914194	0.040193593280914194	+1	NOTCH1,SMAD4
REGULATION OF CELL FATE COMMITMENT%GOBP%GO:0010453	regulation of cell fate commitment	0.040193593280914194	0.040193593280914194	+1	EP300,SOX17
NEGATIVE REGULATION OF CELL-MATRIX ADHESION%GOBP%GO:0001953	negative regulation of cell-matrix adhesion	0.040193593280914194	0.040193593280914194	+1	PTEN,CDKN2A
NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING	Nongenotropic Androgen signaling	0.040193593280914194	0.040193593280914194	+1	PIK3CA,AR
NEGATIVE REGULATION OF CHROMOSOME SEPARATION%GOBP%GO:1905819	negative regulation of chromosome separation	0.040193593280914194	0.040193593280914194	+1	APC,ATM
SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 81%201451	Signaling by BMP	0.040193593280914194	0.040193593280914194	+1	SMAD4,ACVR2A
NEGATIVE REGULATION OF METAPHASE/ANAPHASE TRANSITION OF CELL CYCLE%GOBP%GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	0.040193593280914194	0.040193593280914194	+1	APC,ATM
SEGMENTATION%GOBP%GO:0035282	segmentation	0.040193593280914194	0.040193593280914194	+1	TBX3,WT1
POSITIVE REGULATION OF PROTEIN TARGETING TO MITOCHONDRION%GOBP%GO:1903955	positive regulation of protein targeting to mitochondrion	0.040193593280914194	0.040193593280914194	+1	FBXW7,BAP1
POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION%GOBP%GO:1903749	positive regulation of establishment of protein localization to mitochondrion	0.040193593280914194	0.040193593280914194	+1	FBXW7,BAP1
NEGATIVE REGULATION OF CHROMOSOME SEGREGATION%GOBP%GO:0051985	negative regulation of chromosome segregation	0.040193593280914194	0.040193593280914194	+1	APC,ATM
POSITIVE REGULATION OF PROTEIN LOCALIZATION TO MEMBRANE%GOBP%GO:1905477	positive regulation of protein localization to membrane	0.04104801869254379	0.04104801869254379	+1	PIK3CA,EGFR,EPHA3
NEURON PROJECTION GUIDANCE%GOBP%GO:0097485	neuron projection guidance	0.0414629621219162	0.0414629621219162	+1	NOTCH1,ARHGAP35,EPHA3,EPHB6
AXON GUIDANCE%GOBP%GO:0007411	axon guidance	0.0414629621219162	0.0414629621219162	+1	NOTCH1,ARHGAP35,EPHA3,EPHB6
REGULATION OF ENDOTHELIAL CELL MIGRATION%GOBP%GO:0010594	regulation of endothelial cell migration	0.0414629621219162	0.0414629621219162	+1	NF1,GATA3,NOTCH1,PIK3CG
ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004	Alzheimer disease-presenilin pathway	0.04220006200133007	0.04220006200133007	+1	NOTCH1,CTNNB1,CDH1
CENTROSOME CYCLE%GOBP%GO:0007098	centrosome cycle	0.04220006200133007	0.04220006200133007	+1	CTNNB1,NPM1,BRCA2
B CELL DIFFERENTIATION%GOBP%GO:0030183	B cell differentiation	0.04220006200133007	0.04220006200133007	+1	FLT3,ATM,KIT
MODULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL%GOBP%GO:0098815	modulation of excitatory postsynaptic potential	0.04237038894141284	0.04237038894141284	+1	PTEN,LRRK2
NEGATIVE REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	0.04237038894141284	0.04237038894141284	+1	BRCA1,NCOR1
REGULATION OF MUSCLE HYPERTROPHY%GOBP%GO:0014743	regulation of muscle hypertrophy	0.04237038894141284	0.04237038894141284	+1	NOTCH1,SMAD4
POSITIVE REGULATION OF GLUCOSE TRANSMEMBRANE TRANSPORT%GOBP%GO:0010828	positive regulation of glucose transmembrane transport	0.04237038894141284	0.04237038894141284	+1	BRAF,PTPN11
TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593	Toll-Like Receptor Pathway 2	0.04237038894141284	0.04237038894141284	+1	MAP2K4,TLR4
PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY	PID_UPA_UPAR_PATHWAY	0.04237038894141284	0.04237038894141284	+1	EGFR,HGF
NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 81%9725371	Nuclear events stimulated by ALK signaling in cancer	0.04237038894141284	0.04237038894141284	+1	RB1,NPM1
CELLULAR RESPONSE TO BIOTIC STIMULUS%GOBP%GO:0071216	cellular response to biotic stimulus	0.04299240150252579	0.04299240150252579	+1	TP53,NOTCH1,TLR4,SMC1A
REGULATION OF ANGIOGENESIS%GOBP%GO:0045765	regulation of angiogenesis	0.043007218400288455	0.043007218400288455	+1	NF1,CTNNB1,RUNX1,PIK3CG,BRCA1
REGULATION OF SYNAPTIC VESICLE CLUSTERING%GOBP%GO:2000807	regulation of synaptic vesicle clustering	0.043126060089105196	0.043126060089105196	+1	PTEN
CARDIAC CELL FATE DETERMINATION%GOBP%GO:0060913	cardiac cell fate determination	0.043126060089105196	0.043126060089105196	+1	SOX17
HALLMARK_HYPOXIA%MSIGDBHALLMARK%HALLMARK_HYPOXIA	HALLMARK_HYPOXIA	0.043126060089105196	0.043126060089105196	+1	VHL,EGFR,CDKN1B,CDKN1A
RESPONSE TO NITROSATIVE STRESS%GOBP%GO:0051409	response to nitrosative stress	0.043126060089105196	0.043126060089105196	+1	ATM
REGULATION OF BRANCHING MORPHOGENESIS OF A NERVE%GOBP%GO:2000172	regulation of branching morphogenesis of a nerve	0.043126060089105196	0.043126060089105196	+1	LRRK2
POSITIVE REGULATION OF APOPTOTIC PROCESS INVOLVED IN DEVELOPMENT%GOBP%GO:1904747	positive regulation of apoptotic process involved in development	0.043126060089105196	0.043126060089105196	+1	NOTCH1
G-CSF%IOB%G-CSF	G-CSF	0.043126060089105196	0.043126060089105196	+1	CDKN1B,PTPN11
POSITIVE REGULATION OF MACROPHAGE APOPTOTIC PROCESS%GOBP%GO:2000111	positive regulation of macrophage apoptotic process	0.043126060089105196	0.043126060089105196	+1	CDKN2A
REGULATION OF NEURON MATURATION%GOBP%GO:0014041	regulation of neuron maturation	0.043126060089105196	0.043126060089105196	+1	LRRK2
REGULATION OF OXIDATIVE STRESS-INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.043126060089105196	0.043126060089105196	+1	FBXW7,NFE2L2
POSITIVE REGULATION OF CELL PROLIFERATION BY VEGF-ACTIVATED PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	0.043126060089105196	0.043126060089105196	+1	PDGFRA
NEGATIVE REGULATION OF SREBP SIGNALING PATHWAY%GOBP%GO:2000639	negative regulation of SREBP signaling pathway	0.043126060089105196	0.043126060089105196	+1	FBXW7
STEM CELL FATE COMMITMENT%GOBP%GO:0048865	stem cell fate commitment	0.043126060089105196	0.043126060089105196	+1	SOX9
LUTEINIZATION%GOBP%GO:0001553	luteinization	0.043126060089105196	0.043126060089105196	+1	PDGFRA
NATURAL KILLER CELL CHEMOTAXIS%GOBP%GO:0035747	natural killer cell chemotaxis	0.043126060089105196	0.043126060089105196	+1	PIK3CG
CARDIAC CONDUCTION SYSTEM DEVELOPMENT%GOBP%GO:0003161	cardiac conduction system development	0.043126060089105196	0.043126060089105196	+1	TBX3,SMAD4
GONADOTROPIN SECRETION%GOBP%GO:0032274	gonadotropin secretion	0.043126060089105196	0.043126060089105196	+1	TBX3
REGULATION OF MAST CELL CYTOKINE PRODUCTION%GOBP%GO:0032763	regulation of mast cell cytokine production	0.043126060089105196	0.043126060089105196	+1	KIT
REGULATION OF VACUOLAR TRANSPORT%GOBP%GO:1903335	regulation of vacuolar transport	0.043126060089105196	0.043126060089105196	+1	LRRK2
MESENCHYMAL STEM CELL DIFFERENTIATION%GOBP%GO:0072497	mesenchymal stem cell differentiation	0.043126060089105196	0.043126060089105196	+1	CTNNB1
NEGATIVE REGULATION OF HELICASE ACTIVITY%GOBP%GO:0051097	negative regulation of helicase activity	0.043126060089105196	0.043126060089105196	+1	TP53
POSITIVE REGULATION OF HEPARAN SULFATE PROTEOGLYCAN BIOSYNTHETIC PROCESS%GOBP%GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	0.043126060089105196	0.043126060089105196	+1	CTNNB1
NEPHRIC DUCT FORMATION%GOBP%GO:0072179	nephric duct formation	0.043126060089105196	0.043126060089105196	+1	GATA3
NEGATIVE REGULATION OF GLOMERULAR MESANGIAL CELL PROLIFERATION%GOBP%GO:0072125	negative regulation of glomerular mesangial cell proliferation	0.043126060089105196	0.043126060089105196	+1	WT1
ENDOCARDIUM FORMATION%GOBP%GO:0060214	endocardium formation	0.043126060089105196	0.043126060089105196	+1	SOX17
POSITIVE REGULATION OF THYMOCYTE APOPTOTIC PROCESS%GOBP%GO:0070245	positive regulation of thymocyte apoptotic process	0.043126060089105196	0.043126060089105196	+1	TP53
PRO-B CELL DIFFERENTIATION%GOBP%GO:0002328	pro-B cell differentiation	0.043126060089105196	0.043126060089105196	+1	FLT3
REGULATION OF NK T CELL DIFFERENTIATION%GOBP%GO:0051136	regulation of NK T cell differentiation	0.043126060089105196	0.043126060089105196	+1	TGFBR2
DETECTION OF MECHANICAL STIMULUS%GOBP%GO:0050982	detection of mechanical stimulus	0.043126060089105196	0.043126060089105196	+1	CTNNB1,KIT
MESONEPHRIC TUBULE FORMATION%GOBP%GO:0072172	mesonephric tubule formation	0.043126060089105196	0.043126060089105196	+1	GATA3
POSITIVE REGULATION OF APOPTOTIC PROCESS INVOLVED IN MORPHOGENESIS%GOBP%GO:1902339	positive regulation of apoptotic process involved in morphogenesis	0.043126060089105196	0.043126060089105196	+1	NOTCH1
NEGATIVE REGULATION OF T CELL DIFFERENTIATION%GOBP%GO:0045581	negative regulation of T cell differentiation	0.043126060089105196	0.043126060089105196	+1	RUNX1,CBFB
CENTRAL NERVOUS SYSTEM MYELIN MAINTENANCE%GOBP%GO:0032286	central nervous system myelin maintenance	0.043126060089105196	0.043126060089105196	+1	PTEN
POSITIVE REGULATION OF EPIDERMAL GROWTH FACTOR-ACTIVATED RECEPTOR ACTIVITY%GOBP%GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	0.043126060089105196	0.043126060089105196	+1	FBXW7
FEMALE GONAD DEVELOPMENT%GOBP%GO:0008585	female gonad development	0.043126060089105196	0.043126060089105196	+1	KIT,PDGFRA
POSITIVE REGULATION OF ANDROGEN RECEPTOR ACTIVITY%GOBP%GO:2000825	positive regulation of androgen receptor activity	0.043126060089105196	0.043126060089105196	+1	TAF1
RESPONSE TO HYDROSTATIC PRESSURE%GOBP%GO:0051599	response to hydrostatic pressure	0.043126060089105196	0.043126060089105196	+1	PIK3CA
POSITIVE REGULATION OF MAST CELL CYTOKINE PRODUCTION%GOBP%GO:0032765	positive regulation of mast cell cytokine production	0.043126060089105196	0.043126060089105196	+1	KIT
POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER BY GLUCOSE%GOBP%GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	0.043126060089105196	0.043126060089105196	+1	FOXA2
NEGATIVE REGULATION OF ALPHA-BETA T CELL ACTIVATION%GOBP%GO:0046636	negative regulation of alpha-beta T cell activation	0.043126060089105196	0.043126060089105196	+1	RUNX1,CBFB
PDGF PATHWAY%WIKIPATHWAYS_20240510%WP2526%HOMO SAPIENS	PDGF pathway	0.043126060089105196	0.043126060089105196	+1	MAP2K4,PTPN11
PRE-B CELL ALLELIC EXCLUSION%GOBP%GO:0002331	pre-B cell allelic exclusion	0.043126060089105196	0.043126060089105196	+1	ATM
NEGATIVE REGULATION OF MYOFIBROBLAST DIFFERENTIATION%GOBP%GO:1904761	negative regulation of myofibroblast differentiation	0.043126060089105196	0.043126060089105196	+1	RB1
BRANCHING MORPHOGENESIS OF A NERVE%GOBP%GO:0048755	branching morphogenesis of a nerve	0.043126060089105196	0.043126060089105196	+1	FGFR2
FASCICULATION OF SENSORY NEURON AXON%GOBP%GO:0097155	fasciculation of sensory neuron axon	0.043126060089105196	0.043126060089105196	+1	EPHA3
TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909	Toll-Like Receptor Pathway 1	0.043126060089105196	0.043126060089105196	+1	MAP2K4,TLR4
LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME DATABASE ID RELEASE 81%3642278	Loss of Function of TGFBR2 in Cancer	0.043126060089105196	0.043126060089105196	+1	TGFBR2
MAST CELL CHEMOTAXIS%GOBP%GO:0002551	mast cell chemotaxis	0.043126060089105196	0.043126060089105196	+1	KIT
DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5	Diseases of Cellular Senescence	0.043126060089105196	0.043126060089105196	+1	CDKN2A
REGULATION OF MITOTIC CELL CYCLE, EMBRYONIC%GOBP%GO:0009794	regulation of mitotic cell cycle, embryonic	0.043126060089105196	0.043126060089105196	+1	CTNNB1
VIRAL RNA GENOME REPLICATION%GOBP%GO:0039694	viral RNA genome replication	0.043126060089105196	0.043126060089105196	+1	PCBP1
NEGATIVE REGULATION OF PHOTORECEPTOR CELL DIFFERENTIATION%GOBP%GO:0046533	negative regulation of photoreceptor cell differentiation	0.043126060089105196	0.043126060089105196	+1	SOX9
RESPONSE TO WATER%GOBP%GO:0009415	response to water	0.043126060089105196	0.043126060089105196	+1	PIK3CA
ZYGOTIC SPECIFICATION OF DORSAL/VENTRAL AXIS%GOBP%GO:0007352	zygotic specification of dorsal/ventral axis	0.043126060089105196	0.043126060089105196	+1	SMAD2
GROWTH PLATE CARTILAGE CHONDROCYTE DIFFERENTIATION%GOBP%GO:0003418	growth plate cartilage chondrocyte differentiation	0.043126060089105196	0.043126060089105196	+1	SOX9
REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER BY GLUCOSE%GOBP%GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose	0.043126060089105196	0.043126060089105196	+1	FOXA2
METANEPHRIC GLOMERULUS MORPHOGENESIS%GOBP%GO:0072275	metanephric glomerulus morphogenesis	0.043126060089105196	0.043126060089105196	+1	PDGFRA
ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251	Erlotinib Action Pathway	0.043126060089105196	0.043126060089105196	+1	EGFR
MIRNA TRANSPORT%GOBP%GO:1990428	miRNA transport	0.043126060089105196	0.043126060089105196	+1	TGFBR2
VEGF-ACTIVATED PLATELET-DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway	0.043126060089105196	0.043126060089105196	+1	PDGFRA
METANEPHRIC GLOMERULUS VASCULATURE MORPHOGENESIS%GOBP%GO:0072276	metanephric glomerulus vasculature morphogenesis	0.043126060089105196	0.043126060089105196	+1	PDGFRA
RESPONSE TO FOLLICLE-STIMULATING HORMONE%GOBP%GO:0032354	response to follicle-stimulating hormone	0.043126060089105196	0.043126060089105196	+1	NOTCH1
METANEPHRIC S-SHAPED BODY MORPHOGENESIS%GOBP%GO:0072284	metanephric S-shaped body morphogenesis	0.043126060089105196	0.043126060089105196	+1	WT1
POSITIVE REGULATION OF PROTEIN AUTOUBIQUITINATION%GOBP%GO:1902499	positive regulation of protein autoubiquitination	0.043126060089105196	0.043126060089105196	+1	LRRK2
SISTER CHROMATID BIORIENTATION%GOBP%GO:0031134	sister chromatid biorientation	0.043126060089105196	0.043126060089105196	+1	RB1
TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3645790.4	TGFBR2 Kinase Domain Mutants in Cancer	0.043126060089105196	0.043126060089105196	+1	TGFBR2
EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9630794.4	Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	0.043126060089105196	0.043126060089105196	+1	CDKN2A
NEURAL CREST CELL FATE COMMITMENT%GOBP%GO:0014034	neural crest cell fate commitment	0.043126060089105196	0.043126060089105196	+1	SOX9
MAST CELL MIGRATION%GOBP%GO:0097531	mast cell migration	0.043126060089105196	0.043126060089105196	+1	KIT
METANEPHRIC GLOMERULAR CAPILLARY FORMATION%GOBP%GO:0072277	metanephric glomerular capillary formation	0.043126060089105196	0.043126060089105196	+1	PDGFRA
CARDIAC MUSCLE TISSUE REGENERATION%GOBP%GO:0061026	cardiac muscle tissue regeneration	0.043126060089105196	0.043126060089105196	+1	RUNX1
PROTEIN POLYUBIQUITINATION%GOBP%GO:0000209	protein polyubiquitination	0.043126060089105196	0.043126060089105196	+1	CTNNB1,BRCA1,TAF1,CBFB,SPOP
POSITIVE REGULATION OF TRANSCRIPTION BY GLUCOSE%GOBP%GO:0046016	positive regulation of transcription by glucose	0.043126060089105196	0.043126060089105196	+1	FOXA2
CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3	Cellular response to heat stress	0.043126060089105196	0.043126060089105196	+1	ATM,EP300,ATR
NEGATIVE REGULATION OF MAINTENANCE OF MITOTIC SISTER CHROMATID COHESION%GOBP%GO:0034183	negative regulation of maintenance of mitotic sister chromatid cohesion	0.043126060089105196	0.043126060089105196	+1	ATRX
DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4	Diseases of cellular response to stress	0.043126060089105196	0.043126060089105196	+1	CDKN2A
REGULATION OF BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS%GOBP%GO:0060693	regulation of branching involved in salivary gland morphogenesis	0.043126060089105196	0.043126060089105196	+1	HGF
REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME%R-HSA-9824585.1	Regulation of MITF-M-dependent genes involved in pigmentation	0.043126060089105196	0.043126060089105196	+1	ARID1A,CTNNB1
REGULATION OF MYOFIBROBLAST DIFFERENTIATION%GOBP%GO:1904760	regulation of myofibroblast differentiation	0.043126060089105196	0.043126060089105196	+1	RB1
MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 81%8875791	MET activates STAT3	0.043126060089105196	0.043126060089105196	+1	HGF
NEGATIVE REGULATION OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR SIGNALING PATHWAY%GOBP%GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	0.043126060089105196	0.043126060089105196	+1	ASXL1
NEGATIVE REGULATION OF MICROTUBULE POLYMERIZATION OR DEPOLYMERIZATION%GOBP%GO:0031111	negative regulation of microtubule polymerization or depolymerization	0.043126060089105196	0.043126060089105196	+1	APC,NAV3
REGULATION OF LATE ENDOSOME TO LYSOSOME TRANSPORT%GOBP%GO:1902822	regulation of late endosome to lysosome transport	0.043126060089105196	0.043126060089105196	+1	LRRK2
EPITHELIAL CELL DIFFERENTIATION INVOLVED IN PROSTATE GLAND DEVELOPMENT%GOBP%GO:0060742	epithelial cell differentiation involved in prostate gland development	0.043126060089105196	0.043126060089105196	+1	FGFR2
NEURON RECOGNITION%GOBP%GO:0008038	neuron recognition	0.043126060089105196	0.043126060089105196	+1	ARHGAP35,EPHA3
REGULATION OF PHOTORECEPTOR CELL DIFFERENTIATION%GOBP%GO:0046532	regulation of photoreceptor cell differentiation	0.043126060089105196	0.043126060089105196	+1	SOX9
CHONDROCYTE DIFFERENTIATION INVOLVED IN ENDOCHONDRAL BONE MORPHOGENESIS%GOBP%GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	0.043126060089105196	0.043126060089105196	+1	SOX9
EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5	Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	0.043126060089105196	0.043126060089105196	+1	CDKN2A
EMBRYONIC SKELETAL LIMB JOINT MORPHOGENESIS%GOBP%GO:0036023	embryonic skeletal limb joint morphogenesis	0.043126060089105196	0.043126060089105196	+1	CTNNB1
NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2	NFE2L2 regulating TCA cycle genes	0.043126060089105196	0.043126060089105196	+1	NFE2L2
POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION INVOLVED IN LUNG MORPHOGENESIS%GOBP%GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	0.043126060089105196	0.043126060089105196	+1	FGFR2
RAF ACTIVATION%REACTOME%R-HSA-5673000.4	RAF activation	0.043126060089105196	0.043126060089105196	+1	BRAF,PPP2R1A
NEGATIVE REGULATION OF CARDIAC MUSCLE CONTRACTION%GOBP%GO:0055118	negative regulation of cardiac muscle contraction	0.043126060089105196	0.043126060089105196	+1	PIK3CG
EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING	EPHA forward signaling	0.043126060089105196	0.043126060089105196	+1	EPHA3,PIK3CG
DETECTION OF FUNGUS%GOBP%GO:0016046	detection of fungus	0.043126060089105196	0.043126060089105196	+1	TLR4
LACRIMAL GLAND DEVELOPMENT%GOBP%GO:0032808	lacrimal gland development	0.043126060089105196	0.043126060089105196	+1	FGFR2
POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001235	positive regulation of apoptotic signaling pathway	0.043126060089105196	0.043126060089105196	+1	TP53,FBXW7,TLR4
MODEL FOR REGULATION OF MSMP EXPRESSION IN CANCER CELLS AND ITS PROANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20240510%WP4397%HOMO SAPIENS	Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors	0.043126060089105196	0.043126060089105196	+1	CTCF
REGULATION OF CAMKK-AMPK SIGNALING CASCADE%GOBP%GO:1905289	regulation of CAMKK-AMPK signaling cascade	0.043126060089105196	0.043126060089105196	+1	LRRK2
N-TERMINAL PEPTIDYL-LYSINE ACETYLATION%GOBP%GO:0018076	N-terminal peptidyl-lysine acetylation	0.043126060089105196	0.043126060089105196	+1	EP300
CELL MIGRATION INVOLVED IN ENDOCARDIAL CUSHION FORMATION%GOBP%GO:0003273	cell migration involved in endocardial cushion formation	0.043126060089105196	0.043126060089105196	+1	NOTCH1
FOREBRAIN DEVELOPMENT%GOBP%GO:0030900	forebrain development	0.043126060089105196	0.043126060089105196	+1	PTEN,NF1,LRRK2,FGFR2
MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20240510%WP3938%HOMO SAPIENS	miR 222 in exercise induced cardiac growth	0.043126060089105196	0.043126060089105196	+1	CDKN1B
EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4	Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	0.043126060089105196	0.043126060089105196	+1	CDKN2A
ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS	AlphaE beta7 integrin cell surface interactions	0.043126060089105196	0.043126060089105196	+1	CDH1
ESTABLISHMENT OR MAINTENANCE OF ACTIN CYTOSKELETON POLARITY%GOBP%GO:0030950	establishment or maintenance of actin cytoskeleton polarity	0.043126060089105196	0.043126060089105196	+1	ARHGAP35
ERYTHROPOIETIN-MEDIATED SIGNALING PATHWAY%GOBP%GO:0038162	erythropoietin-mediated signaling pathway	0.043126060089105196	0.043126060089105196	+1	KIT
NR1D1 (REV-ERBA) REPRESSES GENE EXPRESSION%REACTOME%R-HSA-1368071.5	NR1D1 (REV-ERBA) represses gene expression	0.043126060089105196	0.043126060089105196	+1	NCOR1
LIMB JOINT MORPHOGENESIS%GOBP%GO:0036022	limb joint morphogenesis	0.043126060089105196	0.043126060089105196	+1	CTNNB1
NEGATIVE REGULATION OF PRO-B CELL DIFFERENTIATION%GOBP%GO:2000974	negative regulation of pro-B cell differentiation	0.043126060089105196	0.043126060089105196	+1	NOTCH1
LEUKEMIA INHIBITORY FACTOR SIGNALING PATHWAY%GOBP%GO:0048861	leukemia inhibitory factor signaling pathway	0.043126060089105196	0.043126060089105196	+1	LIFR
POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION%GOBP%GO:1904951	positive regulation of establishment of protein localization	0.043126060089105196	0.043126060089105196	+1	FBXW7,CDH1,BAP1,TLR4,EP300
POSITIVE REGULATION OF INTEGRIN BIOSYNTHETIC PROCESS%GOBP%GO:0045726	positive regulation of integrin biosynthetic process	0.043126060089105196	0.043126060089105196	+1	AR
REGULATION OF CENTRIOLE-CENTRIOLE COHESION%GOBP%GO:0030997	regulation of centriole-centriole cohesion	0.043126060089105196	0.043126060089105196	+1	CTNNB1
NEGATIVE REGULATION OF MAINTENANCE OF SISTER CHROMATID COHESION%GOBP%GO:0034092	negative regulation of maintenance of sister chromatid cohesion	0.043126060089105196	0.043126060089105196	+1	ATRX
MITRAL VALVE FORMATION%GOBP%GO:0003192	mitral valve formation	0.043126060089105196	0.043126060089105196	+1	NOTCH1
CELLULAR RESPONSE TO ACTINOMYCIN D%GOBP%GO:0072717	cellular response to actinomycin D	0.043126060089105196	0.043126060089105196	+1	TP53
EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5	Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	0.043126060089105196	0.043126060089105196	+1	CDKN2A
REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION%GOBP%GO:0002761	regulation of myeloid leukocyte differentiation	0.04315769694428109	0.04315769694428109	+1	FBXW7,RUNX1,TLR4
HALLMARK_MITOTIC_SPINDLE%MSIGDBHALLMARK%HALLMARK_MITOTIC_SPINDLE	HALLMARK_MITOTIC_SPINDLE	0.043790071563897755	0.043790071563897755	+1	NF1,BRCA2,SMC1A,SMC3
REGULATION OF VASCULATURE DEVELOPMENT%GOBP%GO:1901342	regulation of vasculature development	0.044370352327192046	0.044370352327192046	+1	NF1,CTNNB1,RUNX1,PIK3CG,BRCA1
NEGATIVE REGULATION OF TELOMERE MAINTENANCE%GOBP%GO:0032205	negative regulation of telomere maintenance	0.044370352327192046	0.044370352327192046	+1	TP53,ATM
REGULATION OF G0 TO G1 TRANSITION%GOBP%GO:0070316	regulation of G0 to G1 transition	0.044370352327192046	0.044370352327192046	+1	ARID1A,PBRM1
HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK	HIF-2-alpha transcription factor network	0.044370352327192046	0.044370352327192046	+1	VHL,EP300
TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME DATABASE ID RELEASE 81%8953750	Transcriptional Regulation by E2F6	0.044370352327192046	0.044370352327192046	+1	BRCA1,EZH2
IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS	IL8- and CXCR2-mediated signaling events	0.044370352327192046	0.044370352327192046	+1	PIK3CG,PPP2R1A
REGULATION OF DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	0.044370352327192046	0.044370352327192046	+1	ATM,ATR
DEVELOPMENT OF PRIMARY FEMALE SEXUAL CHARACTERISTICS%GOBP%GO:0046545	development of primary female sexual characteristics	0.044370352327192046	0.044370352327192046	+1	KIT,PDGFRA
POSITIVE REGULATION OF PROTEIN UBIQUITINATION%GOBP%GO:0031398	positive regulation of protein ubiquitination	0.04547245266930623	0.04547245266930623	+1	PTEN,FBXW7,LRRK2
REGULATION OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE%GOBP%GO:1903076	regulation of protein localization to plasma membrane	0.04547245266930623	0.04547245266930623	+1	EGFR,EPHA3,AR
MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-1592230.4	Mitochondrial biogenesis	0.04547245266930623	0.04547245266930623	+1	IDH2,TBL1XR1,NCOR1
INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034	Integrin signalling pathway	0.046226168869450565	0.046226168869450565	+1	PIK3CA,MAP2K4,BRAF,PIK3CG
TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20240510%WP4566%HOMO SAPIENS	Translation inhibitors in chronically activated PDGFRA cells	0.046463372920107195	0.046463372920107195	+1	MAP2K4,EIF4A2
OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20240510%WP5424%HOMO SAPIENS	Omega 6 fatty acids in senescence	0.046463372920107195	0.046463372920107195	+1	RB1,CDKN1A
IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K	IL2 signaling events mediated by PI3K	0.046463372920107195	0.046463372920107195	+1	PIK3CA,PTPN11
ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS	ErbB4 signaling events	0.046463372920107195	0.046463372920107195	+1	PIK3CA,NCOR1
POSITIVE REGULATION OF G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	0.046463372920107195	0.046463372920107195	+1	EGFR,CCND1
CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT	Class I PI3K signaling events mediated by Akt	0.046463372920107195	0.046463372920107195	+1	CDKN1B,CDKN1A
HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20240510%WP4249%HOMO SAPIENS	Hedgehog signaling pathway	0.046463372920107195	0.046463372920107195	+1	CCND1,SPOP
LIMBIC SYSTEM DEVELOPMENT%GOBP%GO:0021761	limbic system development	0.046463372920107195	0.046463372920107195	+1	PTEN,FGFR2
LEUKOCYTE HOMEOSTASIS%GOBP%GO:0001776	leukocyte homeostasis	0.046463372920107195	0.046463372920107195	+1	FLT3,PPP2R1A
COLUMNAR/CUBOIDAL EPITHELIAL CELL DIFFERENTIATION%GOBP%GO:0002065	columnar/cuboidal epithelial cell differentiation	0.046463372920107195	0.046463372920107195	+1	FGFR2,SMAD2
DNA-TEMPLATED TRANSCRIPTION ELONGATION%GOBP%GO:0006354	DNA-templated transcription elongation	0.046463372920107195	0.046463372920107195	+1	PBRM1,SETD2
ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS	Arf6 signaling events	0.046463372920107195	0.046463372920107195	+1	EGFR,HGF
NEGATIVE REGULATION OF OSTEOBLAST DIFFERENTIATION%GOBP%GO:0045668	negative regulation of osteoblast differentiation	0.046463372920107195	0.046463372920107195	+1	NOTCH1,SOX9
INTERFERON SIGNALING%REACTOME%R-HSA-913531.4	Interferon Signaling	0.046661904507481027	0.046661904507481027	+1	TP53,NPM1,PPP2R1A,EIF4A2,PTPN11
HALLMARK_MYOGENESIS%MSIGDBHALLMARK%HALLMARK_MYOGENESIS	HALLMARK_MYOGENESIS	0.0477199504920608	0.0477199504920608	+1	RB1,NOTCH1,CDKN1A,EIF4A2
TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA	Trk receptor signaling mediated by PI3K and PLC-gamma	0.04852824341259221	0.04852824341259221	+1	PIK3CA,CCND1
POSTREPLICATION REPAIR%GOBP%GO:0006301	postreplication repair	0.04852824341259221	0.04852824341259221	+1	BRCA1,POLQ
PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY	PID_ILK_PATHWAY	0.04852824341259221	0.04852824341259221	+1	CTNNB1,CCND1
MOLTING CYCLE%GOBP%GO:0042303	molting cycle	0.04852824341259221	0.04852824341259221	+1	SOX9,FGFR2
ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20240510%WP4535%HOMO SAPIENS	Envelope proteins and their potential roles in EDMD physiopathology	0.04852824341259221	0.04852824341259221	+1	SMAD4,SMAD2
T CELL COSTIMULATION%GOBP%GO:0031295	T cell costimulation	0.04852824341259221	0.04852824341259221	+1	PIK3CA,PTPN11
FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20240510%WP314%HOMO SAPIENS	Fas ligand pathway and stress induction of heat shock proteins	0.04852824341259221	0.04852824341259221	+1	RB1,MAP2K4
REGULATION OF HIPPO SIGNALING%GOBP%GO:0035330	regulation of hippo signaling	0.04852824341259221	0.04852824341259221	+1	AJUBA,PPP2R1A
REGULATION OF CARTILAGE DEVELOPMENT%GOBP%GO:0061035	regulation of cartilage development	0.04852824341259221	0.04852824341259221	+1	SOX9,PTPN11
NEGATIVE REGULATION OF MITOTIC NUCLEAR DIVISION%GOBP%GO:0045839	negative regulation of mitotic nuclear division	0.04852824341259221	0.04852824341259221	+1	APC,ATM
POSITIVE REGULATION OF CD4-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2000516	positive regulation of CD4-positive, alpha-beta T cell activation	0.04852824341259221	0.04852824341259221	+1	EP300,TGFBR2
NEGATIVE REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION%GOBP%GO:0002762	negative regulation of myeloid leukocyte differentiation	0.04852824341259221	0.04852824341259221	+1	FBXW7,TLR4
SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS	Syndecan-2-mediated signaling events	0.04852824341259221	0.04852824341259221	+1	NF1,FGFR3
LYMPHOCYTE DIFFERENTIATION%GOBP%GO:0030098	lymphocyte differentiation	0.04852824341259221	0.04852824341259221	+1	GATA3,FLT3,ATM,KIT
TNFALPHA%IOB%TNFALPHA	TNFalpha	0.04852824341259221	0.04852824341259221	+1	EGFR,RB1,FBXW7,PTPN11
REGULATION OF CELLULAR SENESCENCE%GOBP%GO:2000772	regulation of cellular senescence	0.04852824341259221	0.04852824341259221	+1	TP53,PTEN
HAIR CYCLE%GOBP%GO:0042633	hair cycle	0.04852824341259221	0.04852824341259221	+1	SOX9,FGFR2
MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 81%975871	MyD88 cascade initiated on plasma membrane	0.0486049103174014	0.0486049103174014	+1	TP53,MAP2K4,PPP2R1A
TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.3	Toll Like Receptor 5 (TLR5) Cascade	0.0486049103174014	0.0486049103174014	+1	TP53,MAP2K4,PPP2R1A
TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-HSA-168142.3	Toll Like Receptor 10 (TLR10) Cascade	0.0486049103174014	0.0486049103174014	+1	TP53,MAP2K4,PPP2R1A
UCH PROTEINASES%REACTOME%R-HSA-5689603.4	UCH proteinases	0.04993906863243961	0.04993906863243961	+1	BAP1,ASXL1,TGFBR2