GO.ID Description p.Val FDR Phenotype Genes GO:0034109 homotypic cell-cell adhesion 1.834168662428844e-15 1.834168662428844e-15 +1 GP1BA,ITGB3,MYL9,TUBB1,ALOX12,CD9,DMTN,ILK,FERMT3,CCL5,ACTB,MYL12A,TLN1,ACTG1,FLNA,CD99,PLEK,GNAS,HSPB1 GO:0030168 platelet activation 1.834168662428844e-15 1.834168662428844e-15 +1 GP9,TREML1,PF4,GP1BA,ITGB3,MYL9,TUBB1,ALOX12,CD9,DMTN,ILK,FERMT3,P2RX1,ACTB,MYL12A,TLN1,ACTG1,FLNA,PLEK,GNAS,HSPB1 GO:0070527 platelet aggregation 2.58017631268421e-15 2.58017631268421e-15 +1 GP1BA,ITGB3,MYL9,TUBB1,ALOX12,CD9,DMTN,ILK,FERMT3,ACTB,MYL12A,TLN1,ACTG1,FLNA,PLEK,GNAS,HSPB1 GO:0007596 blood coagulation 4.0766377181062517e-13 4.0766377181062517e-13 +1 GP9,TREML1,PF4,GP1BA,ITGB3,MYL9,F13A1,TUBB1,ALOX12,C6ORF25,CD9,DMTN,ILK,FERMT3,P2RX1,ACTB,MYL12A,TLN1,ACTG1,FLNA,PLEK,GNAS,HSPB1 GO:0007599 hemostasis 4.11888697576423e-13 4.11888697576423e-13 +1 GP9,TREML1,PF4,GP1BA,ITGB3,MYL9,F13A1,TUBB1,ALOX12,C6ORF25,CD9,DMTN,ILK,FERMT3,P2RX1,ACTB,MYL12A,TLN1,ACTG1,FLNA,PLEK,GNAS,HSPB1 GO:0042060 wound healing 4.11888697576423e-13 4.11888697576423e-13 +1 GP9,TREML1,PF4,GP1BA,ITGB3,MYL9,F13A1,TUBB1,ALOX12,C6ORF25,CD9,DMTN,TPM1,ILK,FERMT3,P2RX1,GPX1,CHMP6,CD151,ACTB,TIMP1,MYL12A,TGFB1,TLN1,ACTG1,FLNA,ITGB1,PLEK,GNAS,HSPB1 GO:0050817 coagulation 4.11888697576423e-13 4.11888697576423e-13 +1 GP9,TREML1,PF4,GP1BA,ITGB3,MYL9,F13A1,TUBB1,ALOX12,C6ORF25,CD9,DMTN,ILK,FERMT3,P2RX1,ACTB,MYL12A,TLN1,ACTG1,FLNA,PLEK,GNAS,HSPB1 GO:0050878 regulation of body fluid levels 4.216098816434705e-10 4.216098816434705e-10 +1 GP9,TREML1,PF4,GP1BA,ITGB3,MYL9,F13A1,TUBB1,ALOX12,C6ORF25,CD9,DMTN,ILK,FERMT3,P2RX1,ACTB,MYL12A,TLN1,USF2,ACTG1,FLNA,PLEK,GNAS,HSPB1 GO:0007015 actin filament organization 1.1585984388814404e-7 1.1585984388814404e-7 +1 ARHGAP6,ESAM,CTTN,GAS2L1,DMTN,TPM1,TPM4,PDLIM1,ACTN1,GSN,ARPC1B,ARPC5,TMSB4X,WDR1,MTPN,ACTG1,DBNL,FLNA,ARF1,PLEK,BRK1,TPM3,DIAPH1 GO:1902903 regulation of supramolecular fiber organization 1.689622867633167e-7 1.689622867633167e-7 +1 CLU,ARHGAP6,ESAM,CTTN,SNCA,DMTN,TPM1,GSN,GPX1,ARPC1B,ARPC5,TMSB4X,WDR1,APP,MTPN,ACTG1,DBNL,FLNA,ARF1,PLEK,BRK1 GO:0032956 regulation of actin cytoskeleton organization 3.813229471735515e-7 3.813229471735515e-7 +1 ITGB3,ARHGAP6,ESAM,CTTN,DMTN,TPM1,GSN,ARPC1B,ARPC5,TMSB4X,WDR1,TGFB1,MTPN,ACTG1,DBNL,FLNA,ARF1,ARHGDIB,PLEK,BRK1 GO:0007229 integrin-mediated signaling pathway 6.562109094338202e-7 6.562109094338202e-7 +1 ITGA2B,ITGB3,C6ORF25,DMTN,ILK,FERMT3,LIMS1,TIMP1,TLN1,FLNA,ITGB1,PLEK GO:0110053 regulation of actin filament organization 9.364779769007346e-7 9.364779769007346e-7 +1 ARHGAP6,ESAM,CTTN,DMTN,TPM1,GSN,ARPC1B,ARPC5,TMSB4X,WDR1,MTPN,ACTG1,DBNL,FLNA,ARF1,PLEK,BRK1 GO:0032970 regulation of actin filament-based process 0.0000017359367154882633 0.0000017359367154882633 +1 ITGB3,ARHGAP6,ESAM,CTTN,DMTN,TPM1,GSN,ARPC1B,ARPC5,TMSB4X,WDR1,TGFB1,MTPN,ACTG1,DBNL,FLNA,ARF1,ARHGDIB,PLEK,BRK1 GO:0140029 exocytic process 0.000002599222413562905 0.000002599222413562905 +1 SEPT5,SNCA,DMTN,SCFD2,P2RX1,RAB10,STX11,SNAP23,STXBP2,PLEK GO:0008154 actin polymerization or depolymerization 0.0000033771400990899224 0.0000033771400990899224 +1 ARHGAP6,ESAM,CTTN,DMTN,GSN,ARPC1B,ARPC5,TMSB4X,WDR1,MTPN,DBNL,PLEK,BRK1,DIAPH1 GO:0008064 regulation of actin polymerization or depolymerization 0.00001306990718453609 0.00001306990718453609 +1 ESAM,CTTN,DMTN,GSN,ARPC1B,ARPC5,TMSB4X,WDR1,MTPN,DBNL,PLEK,BRK1 GO:0051651 maintenance of location in cell 0.00001425809036693751 0.00001425809036693751 +1 GP9,GP1BA,ITGB3,SNCA,GSN,FKBP1A,TMSB4X,TGFB1,SRGN,FLNA,FTH1,GSTO1,DIAPH1,SKP1 GO:0030832 regulation of actin filament length 0.000014760230202030933 0.000014760230202030933 +1 ESAM,CTTN,DMTN,GSN,ARPC1B,ARPC5,TMSB4X,WDR1,MTPN,DBNL,PLEK,BRK1 GO:0030100 regulation of endocytosis 0.00003554517849401159 0.00003554517849401159 +1 ITGB3,CLU,SNCA,RUFY1,CD151,ACTB,PACSIN2,TGFB1,ACTG1,ARF1,HMGB1,SNX3,LDLRAP1,RAB4A,AP2M1 GO:1904062 regulation of monoatomic cation transmembrane transport 0.000037470797852811276 0.000037470797852811276 +1 ITGB3,SCN1B,SNCA,P2RX1,FHL1,YWHAH,GNB5,FKBP1A,TMSB4X,TGFB1,FLNA,ITGB1,GSTO1,G6PD,STOM,DIAPH1 GO:0010543 regulation of platelet activation 0.00008509133513712481 0.00008509133513712481 +1 GP9,GP1BA,ALOX12,CD9,DMTN,FLNA,PLEK GO:0030041 actin filament polymerization 0.0001302235304367338 0.0001302235304367338 +1 ARHGAP6,ESAM,CTTN,DMTN,GSN,ARPC1B,ARPC5,TMSB4X,MTPN,DBNL,DIAPH1 GO:0010572 positive regulation of platelet activation 0.00013507826794266346 0.00013507826794266346 +1 GP9,GP1BA,FLNA,PLEK GO:0051258 protein polymerization 0.00013507826794266346 0.00013507826794266346 +1 ARHGAP6,ESAM,TUBB1,CTTN,SNCA,DMTN,GSN,ARPC1B,ARPC5,TMSB4X,GPX4,MTPN,DBNL,DIAPH1 GO:0043254 regulation of protein-containing complex assembly 0.0001457515820775623 0.0001457515820775623 +1 CLU,ESAM,CTTN,SNCA,DMTN,GSN,ARPC1B,ARPC5,TMSB4X,RIOK3,MTPN,RAP1B,DBNL,HMGB1,PLEK,BRK1,SVIP GO:0030220 platelet formation 0.000149581419241446 0.000149581419241446 +1 CLEC1B,TUBB1,C6ORF25,ACTN1,WDR1 GO:0001667 ameboidal-type cell migration 0.0001749687701285536 0.0001749687701285536 +1 SPARC,ITGB3,FSTL1,DMTN,ILK,PDLIM1,GPX1,RAB11A,TIMP1,TMSB4X,TGFB1,ADIPOR1,HMGB1,ITGB1,ARHGDIB,GLUL,HSPB1 GO:0031532 actin cytoskeleton reorganization 0.00018736184281534183 0.00018736184281534183 +1 ESAM,CTTN,DMTN,PARVB,GSN,TGFB1,FLNA,ARHGDIB,PLEK GO:0006874 intracellular calcium ion homeostasis 0.0002121857455578346 0.0002121857455578346 +1 GP9,GP1BA,ITGB3,SNCA,P2RX1,CCL5,MCUR1,ATP2A3,FKBP1A,TGFB1,APP,FLNA,GSTO1,DIAPH1 GO:0036344 platelet morphogenesis 0.00021573315067526194 0.00021573315067526194 +1 CLEC1B,TUBB1,C6ORF25,ACTN1,WDR1 GO:0034329 cell junction assembly 0.00024598613200916 0.00024598613200916 +1 CLDN5,ITGB3,ARHGAP6,ESAM,CTTN,CD9,SNCA,DMTN,ACTN1,LIMS1,ACTB,WDR1,APP,TLN1,RAP1B,ACTG1,DBNL GO:0010959 regulation of metal ion transport 0.00032266900261687615 0.00032266900261687615 +1 ITGB3,SCN1B,SNCA,P2RX1,CCL5,FHL1,YWHAH,GNB5,FKBP1A,TGFB1,FLNA,ITGB1,GSTO1,G6PD,STOM,DIAPH1 GO:0022898 regulation of transmembrane transporter activity 0.0003370972392988866 0.0003370972392988866 +1 SCN1B,SNCA,CAPN1,FHL1,YWHAH,GNB5,ACTB,FKBP1A,TMSB4X,APP,ITGB1,GSTO1,STOM GO:0007044 cell-substrate junction assembly 0.000348530550434625 0.000348530550434625 +1 ITGB3,ARHGAP6,CTTN,DMTN,ACTN1,LIMS1,TLN1,ACTG1 GO:0051209 release of sequestered calcium ion into cytosol 0.00035133518922587947 0.00035133518922587947 +1 GP9,GP1BA,ITGB3,SNCA,FKBP1A,TGFB1,FLNA,GSTO1,DIAPH1 GO:0051283 negative regulation of sequestering of calcium ion 0.00037077373112710354 0.00037077373112710354 +1 GP9,GP1BA,ITGB3,SNCA,FKBP1A,TGFB1,FLNA,GSTO1,DIAPH1 GO:0031589 cell-substrate adhesion 0.0003719305462443835 0.0003719305462443835 +1 ITGA2B,ITGB3,ARHGAP6,CTTN,DMTN,ILK,ACTN1,PARVB,FERMT3,RSU1,LIMS1,TLN1,ACTG1,FLNA,ITGB1 GO:0007160 cell-matrix adhesion 0.0003738243623643821 0.0003738243623643821 +1 ITGA2B,ITGB3,ARHGAP6,CTTN,DMTN,ILK,ACTN1,FERMT3,LIMS1,TLN1,ACTG1,ITGB1 GO:0051282 regulation of sequestering of calcium ion 0.00040837167633217124 0.00040837167633217124 +1 GP9,GP1BA,ITGB3,SNCA,FKBP1A,TGFB1,FLNA,GSTO1,DIAPH1 GO:0055074 calcium ion homeostasis 0.0004151829329538542 0.0004151829329538542 +1 GP9,GP1BA,ITGB3,SNCA,P2RX1,CCL5,MCUR1,ATP2A3,FKBP1A,TGFB1,APP,FLNA,GSTO1,DIAPH1 GO:0051208 sequestering of calcium ion 0.0005118890048224046 0.0005118890048224046 +1 GP9,GP1BA,ITGB3,SNCA,FKBP1A,TGFB1,FLNA,GSTO1,DIAPH1 GO:0150115 cell-substrate junction organization 0.0005323346935581377 0.0005323346935581377 +1 ITGB3,ARHGAP6,CTTN,DMTN,ACTN1,LIMS1,TLN1,ACTG1 GO:0032409 regulation of transporter activity 0.0005583776092774142 0.0005583776092774142 +1 SCN1B,SNCA,CAPN1,FHL1,YWHAH,GNB5,ACTB,FKBP1A,TMSB4X,APP,ITGB1,GSTO1,STOM GO:0051235 maintenance of location 0.0006735539859643749 0.0006735539859643749 +1 GP9,GP1BA,ITGB3,SNCA,GSN,FKBP1A,TMSB4X,TGFB1,SRGN,FLNA,FTH1,GSTO1,DIAPH1,SKP1 GO:0070588 calcium ion transmembrane transport 0.0006735539859643749 0.0006735539859643749 +1 GP9,GP1BA,ITGB3,SNCA,P2RX1,MCUR1,GNB5,ATP2A3,FKBP1A,TGFB1,FLNA,GSTO1,G6PD,DIAPH1 GO:0010763 positive regulation of fibroblast migration 0.0007019224003986912 0.0007019224003986912 +1 ITGB3,DMTN,TGFB1,ITGB1 GO:0030833 regulation of actin filament polymerization 0.0007197766793759212 0.0007197766793759212 +1 ESAM,CTTN,DMTN,GSN,ARPC1B,ARPC5,TMSB4X,MTPN,DBNL GO:0010761 fibroblast migration 0.000759696293098713 0.000759696293098713 +1 ITGB3,DMTN,ILK,PDLIM1,TGFB1,ITGB1 GO:1905475 regulation of protein localization to membrane 0.0008130592090777544 0.0008130592090777544 +1 DMTN,PGRMC1,GSN,ACTB,TGFB1,ITGB1,LDLRAP1,SQSTM1,STOM,AP2M1 GO:0072378 blood coagulation, fibrin clot formation 0.0008721143316052841 0.0008721143316052841 +1 GP9,GP1BA,F13A1,FLNA GO:0097553 calcium ion transmembrane import into cytosol 0.0008721143316052841 0.0008721143316052841 +1 GP9,GP1BA,ITGB3,SNCA,P2RX1,FKBP1A,TGFB1,FLNA,GSTO1,DIAPH1 GO:0061515 myeloid cell development 0.0009247979642405442 0.0009247979642405442 +1 GP9,GP1BA,C6ORF25,DMTN,APP,FLNA,G6PD GO:0035633 maintenance of blood-brain barrier 0.0010146836582026275 0.0010146836582026275 +1 CLDN5,ESAM,ACTB,ACTG1,ITGB1 GO:0048041 focal adhesion assembly 0.0010967060378381517 0.0010967060378381517 +1 ARHGAP6,CTTN,DMTN,ACTN1,LIMS1,TLN1,ACTG1 GO:0031333 negative regulation of protein-containing complex assembly 0.0010967060378381517 0.0010967060378381517 +1 CLU,SNCA,DMTN,GSN,TMSB4X,RIOK3,MTPN,HMGB1,SVIP GO:0016050 vesicle organization 0.0011799650953845657 0.0011799650953845657 +1 ACRBP,SNCA,CHMP6,LAMTOR1,RAB11A,SRGN,AP1B1,RAB32,STX11,SNX3,SNAP23,SQSTM1,VAPA,AP2M1 GO:0034765 regulation of monoatomic ion transmembrane transport 0.001206224575519482 0.001206224575519482 +1 ITGB3,SCN1B,SNCA,P2RX1,FHL1,YWHAH,GNB5,FKBP1A,TMSB4X,TGFB1,FLNA,ITGB1,GSTO1,G6PD,STOM,DIAPH1 GO:0030099 myeloid cell differentiation 0.0012657595196503156 0.0012657595196503156 +1 GP9,PF4,GP1BA,CLEC1B,FAXDC2,TUBB1,C6ORF25,DMTN,ACTN1,WDR1,TGFB1,APP,FLNA,G6PD,EIF2AK1 GO:0032535 regulation of cellular component size 0.0013473770123717747 0.0013473770123717747 +1 ESAM,CTTN,DMTN,GSN,ARPC1B,RAB11A,ARPC5,TMSB4X,WDR1,MTPN,DBNL,PLEK,BRK1,AP2M1 GO:0072376 protein activation cascade 0.001493747284041171 0.001493747284041171 +1 GP9,GP1BA,F13A1,FLNA GO:0007163 establishment or maintenance of cell polarity 0.0016597110711859997 0.0016597110711859997 +1 ILK,PDLIM1,PARVB,GSN,ACTB,WDR1,LMNA,RAP1B,RAB10,ITGB1,SPINT2 GO:1990000 amyloid fibril formation 0.0017075756869751838 0.0017075756869751838 +1 CLU,SNCA,GSN,FKBP1A,APP GO:2001044 regulation of integrin-mediated signaling pathway 0.0017381534066003086 0.0017381534066003086 +1 DMTN,LIMS1,TIMP1,FLNA GO:0030219 megakaryocyte differentiation 0.0017432358194817241 0.0017432358194817241 +1 GP9,PF4,GP1BA,FAXDC2,C6ORF25,FLNA GO:0032271 regulation of protein polymerization 0.0017544279806608724 0.0017544279806608724 +1 ESAM,CTTN,SNCA,DMTN,GSN,ARPC1B,ARPC5,TMSB4X,MTPN,DBNL GO:0006816 calcium ion transport 0.0019215209828144396 0.0019215209828144396 +1 GP9,GP1BA,ITGB3,SNCA,P2RX1,CCL5,MCUR1,GNB5,ATP2A3,FKBP1A,TGFB1,FLNA,GSTO1,G6PD,DIAPH1 GO:0035855 megakaryocyte development 0.002321025760345014 0.002321025760345014 +1 GP9,GP1BA,C6ORF25,FLNA GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 0.00240284217816339 0.00240284217816339 +1 ITGB3,DMTN,ILK,LIMS1,FLNA GO:1902905 positive regulation of supramolecular fiber organization 0.0027637827043893786 0.0027637827043893786 +1 CLU,CTTN,TPM1,GSN,GPX1,WDR1,APP,PLEK,BRK1 GO:0006887 exocytosis 0.0027840456384282193 0.0027840456384282193 +1 SEPT5,SNCA,DMTN,SCFD2,P2RX1,CCL5,RAB11A,RAP1B,RAB10,STX11,SNAP23,STXBP2,PLEK GO:0032412 regulation of monoatomic ion transmembrane transporter activity 0.0028658282602071826 0.0028658282602071826 +1 SCN1B,CAPN1,FHL1,YWHAH,GNB5,FKBP1A,TMSB4X,APP,ITGB1,GSTO1,STOM GO:0044403 biological process involved in symbiotic interaction 0.0034185307987618734 0.0034185307987618734 +1 PF4,ITGB3,GSN,GPX1,CHMP6,CCL5,HMGB1,ITGB1,SNX3,GAPDH,VAPA,STOM GO:0033622 integrin activation 0.003432226060849663 0.003432226060849663 +1 FERMT3,TLN1,RAP1B,PLEK GO:1903421 regulation of synaptic vesicle recycling 0.003432226060849663 0.003432226060849663 +1 SNCA,ACTB,ACTG1,AP2M1 GO:0099003 vesicle-mediated transport in synapse 0.003445425733972746 0.003445425733972746 +1 SEPT5,ITGB3,SNCA,P2RX1,ACTB,RAP1B,ACTG1,STX11,SNAP23,AP2M1 GO:1903169 regulation of calcium ion transmembrane transport 0.0037414159190893 0.0037414159190893 +1 ITGB3,SNCA,P2RX1,GNB5,FKBP1A,TGFB1,GSTO1,G6PD,DIAPH1 GO:1990748 cellular detoxification 0.00376481730560389 0.00376481730560389 +1 PTGS1,GPX1,PRDX6,RDH11,GPX4,SOD2,GSTO1 GO:0055001 muscle cell development 0.0038336180658667947 0.0038336180658667947 +1 MYL9,TPM1,ACTN1,GPX1,WDR1,LMNA,ACTG1,ITGB1,G6PD GO:0034446 substrate adhesion-dependent cell spreading 0.003899685259314171 0.003899685259314171 +1 ITGB3,DMTN,ILK,PARVB,FERMT3,LIMS1,FLNA GO:0019372 lipoxygenase pathway 0.0039069845124040745 0.0039069845124040745 +1 ALOX12,GPX1,GPX4 GO:0003012 muscle system process 0.004008708211507073 0.004008708211507073 +1 MYL9,SCN1B,CTTN,TPM1,TPM4,P2RX1,GSN,MYL6,LMNA,MTPN,FLNA,GSTO1,G6PD,TPM3 GO:0045055 regulated exocytosis 0.004164597948100292 0.004164597948100292 +1 SEPT5,SNCA,DMTN,P2RX1,RAP1B,RAB10,STX11,SNAP23,STXBP2,PLEK GO:0009636 response to toxic substance 0.004267475985834423 0.004267475985834423 +1 PTGS1,SNN,GPX1,CCL5,MPST,PRDX6,RDH11,GPX4,SOD2,GSTO1 GO:0006749 glutathione metabolic process 0.004922740067317379 0.004922740067317379 +1 GPX1,GPX4,SOD2,GSTO1,G6PD GO:0042692 muscle cell differentiation 0.004922740067317379 0.004922740067317379 +1 MYL9,CD9,TPM1,ACTN1,GPX1,WDR1,TGFB1,LMNA,MTPN,SOD2,ACTG1,ITGB1,G6PD GO:0051279 regulation of release of sequestered calcium ion into cytosol 0.005425242349572085 0.005425242349572085 +1 ITGB3,SNCA,FKBP1A,TGFB1,GSTO1,DIAPH1 GO:0097237 cellular response to toxic substance 0.005583496119523845 0.005583496119523845 +1 PTGS1,GPX1,PRDX6,RDH11,GPX4,SOD2,GSTO1 GO:0051017 actin filament bundle assembly 0.005932697196856174 0.005932697196856174 +1 ARHGAP6,DMTN,TPM1,PDLIM1,ACTN1,ACTG1,FLNA,PLEK GO:0006836 neurotransmitter transport 0.005932697196856174 0.005932697196856174 +1 SEPT5,ITGB3,SNCA,P2RX1,RAP1B,STX11,ITGB1,SNAP23,STXBP2 GO:0070493 thrombin-activated receptor signaling pathway 0.0060410628085331135 0.0060410628085331135 +1 GP1BA,SNCA,PLEK GO:0098974 postsynaptic actin cytoskeleton organization 0.0060410628085331135 0.0060410628085331135 +1 ACTB,ACTG1,DBNL GO:2001046 positive regulation of integrin-mediated signaling pathway 0.0060410628085331135 0.0060410628085331135 +1 DMTN,LIMS1,FLNA GO:0099504 synaptic vesicle cycle 0.006203584566125204 0.006203584566125204 +1 SEPT5,SNCA,P2RX1,ACTB,RAP1B,ACTG1,STX11,SNAP23,AP2M1 GO:0050900 leukocyte migration 0.006203584566125204 0.006203584566125204 +1 PF4,GP1BA,ITGB3,PPBP,CD9,MPP1,CCL5,WDR1,TGFB1,APP,HMGB1,ITGB1,CD99 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.006203584566125204 0.006203584566125204 +1 SNCA,P2RX1,GSN,CDKN2D,GPX1,DAP,ATP2A3,DNAJB6,HMGB1 GO:0030834 regulation of actin filament depolymerization 0.006375823932156113 0.006375823932156113 +1 DMTN,GSN,WDR1,MTPN,PLEK GO:0019369 arachidonic acid metabolic process 0.006375823932156113 0.006375823932156113 +1 ALOX12,PTGS1,GPX1,MGLL,GPX4 GO:0061572 actin filament bundle organization 0.006375823932156113 0.006375823932156113 +1 ARHGAP6,DMTN,TPM1,PDLIM1,ACTN1,ACTG1,FLNA,PLEK GO:0010927 cellular component assembly involved in morphogenesis 0.006630131293492168 0.006630131293492168 +1 MYL9,ACRBP,CD9,TPM1,WDR1,ACTG1,ITGB1 GO:0045216 cell-cell junction organization 0.0066611651703721185 0.0066611651703721185 +1 CLDN5,ESAM,CD9,LIMS1,ACTB,WDR1,TLN1,ACTG1,FLNA GO:0006596 polyamine biosynthetic process 0.007145580517019939 0.007145580517019939 +1 ODC1,OAZ1,SAT1 GO:0031623 receptor internalization 0.007145580517019939 0.007145580517019939 +1 ITGB3,CD9,SNCA,ARF1,ITGB1,LDLRAP1,AP2M1 GO:0010631 epithelial cell migration 0.007145580517019939 0.007145580517019939 +1 SPARC,ITGB3,FSTL1,GPX1,RAB11A,TMSB4X,ADIPOR1,HMGB1,ITGB1,GLUL,HSPB1 GO:0052547 regulation of peptidase activity 0.007365692183663766 0.007365692183663766 +1 SNCA,P2RX1,GSN,CDKN2D,GPX1,DAP,ATP2A3,TIMP1,DNAJB6,APP,HMGB1,SPINT2,GAPDH GO:0006898 receptor-mediated endocytosis 0.00744542656677144 0.00744542656677144 +1 ITGB3,CLU,CTTN,CD9,SNCA,DBNL,ARF1,ITGB1,LDLRAP1,AP2M1 GO:0090132 epithelium migration 0.0075734688639461836 0.0075734688639461836 +1 SPARC,ITGB3,FSTL1,GPX1,RAB11A,TMSB4X,ADIPOR1,HMGB1,ITGB1,GLUL,HSPB1 GO:0001505 regulation of neurotransmitter levels 0.007860173955742601 0.007860173955742601 +1 SEPT5,ITGB3,SNCA,P2RX1,RAP1B,STX11,ITGB1,SNAP23,STXBP2 GO:1900024 regulation of substrate adhesion-dependent cell spreading 0.008129285038858602 0.008129285038858602 +1 ITGB3,DMTN,ILK,LIMS1,FLNA GO:0022406 membrane docking 0.008129285038858602 0.008129285038858602 +1 SCFD2,RAB10,STX11,SNX3,STXBP2,PLEK GO:1901888 regulation of cell junction assembly 0.008237653054544202 0.008237653054544202 +1 CLDN5,ARHGAP6,SNCA,DMTN,LIMS1,APP,TLN1,RAP1B,ACTG1 GO:1901163 regulation of trophoblast cell migration 0.008397417383054821 0.008397417383054821 +1 ITGB3,TIMP1,ARHGDIB GO:0098869 cellular oxidant detoxification 0.008435591896596841 0.008435591896596841 +1 PTGS1,GPX1,PRDX6,GPX4,SOD2,GSTO1 GO:0051588 regulation of neurotransmitter transport 0.008435591896596841 0.008435591896596841 +1 SEPT5,ITGB3,SNCA,P2RX1,RAP1B,ITGB1 GO:0045010 actin nucleation 0.00851671790797528 0.00851671790797528 +1 GSN,ARPC1B,ARPC5,ARF1,BRK1 GO:0090130 tissue migration 0.00851671790797528 0.00851671790797528 +1 SPARC,ITGB3,FSTL1,GPX1,RAB11A,TMSB4X,ADIPOR1,HMGB1,ITGB1,GLUL,HSPB1 GO:0030042 actin filament depolymerization 0.00851671790797528 0.00851671790797528 +1 DMTN,GSN,WDR1,MTPN,PLEK GO:0010810 regulation of cell-substrate adhesion 0.008559853684444597 0.008559853684444597 +1 ITGB3,ARHGAP6,DMTN,ILK,RSU1,LIMS1,TLN1,ACTG1,FLNA GO:0043542 endothelial cell migration 0.008778481237912727 0.008778481237912727 +1 SPARC,ITGB3,FSTL1,GPX1,TMSB4X,HMGB1,ITGB1,GLUL,HSPB1 GO:0051924 regulation of calcium ion transport 0.009206241162511872 0.009206241162511872 +1 ITGB3,SNCA,P2RX1,CCL5,GNB5,FKBP1A,TGFB1,GSTO1,G6PD,DIAPH1 GO:0042176 regulation of protein catabolic process 0.009232186772181239 0.009232186772181239 +1 CLU,SNCA,ODC1,CTSA,GPX1,CHMP6,OAZ1,TIMP1,FLNA,SNX3,RBX1,SVIP GO:0006878 intracellular copper ion homeostasis 0.009393862728710572 0.009393862728710572 +1 ANKRD9,APP,ARF1 GO:0099188 postsynaptic cytoskeleton organization 0.009393862728710572 0.009393862728710572 +1 ACTB,ACTG1,DBNL GO:0061450 trophoblast cell migration 0.009393862728710572 0.009393862728710572 +1 ITGB3,TIMP1,ARHGDIB GO:0061684 chaperone-mediated autophagy 0.009393862728710572 0.009393862728710572 +1 CLU,SNCA,CTSA GO:0090109 regulation of cell-substrate junction assembly 0.009393862728710572 0.009393862728710572 +1 ARHGAP6,DMTN,LIMS1,TLN1,ACTG1 GO:0051893 regulation of focal adhesion assembly 0.009393862728710572 0.009393862728710572 +1 ARHGAP6,DMTN,LIMS1,TLN1,ACTG1 GO:0016079 synaptic vesicle exocytosis 0.009393862728710572 0.009393862728710572 +1 SEPT5,SNCA,P2RX1,RAP1B,STX11,SNAP23 GO:0098754 detoxification 0.009762320783852238 0.009762320783852238 +1 PTGS1,GPX1,PRDX6,RDH11,GPX4,SOD2,GSTO1 GO:0048278 vesicle docking 0.009796637745357863 0.009796637745357863 +1 SCFD2,RAB10,STX11,STXBP2,PLEK GO:0008277 regulation of G protein-coupled receptor signaling pathway 0.0102684663077413 0.0102684663077413 +1 ITGB3,RGS18,SNCA,RGS10,MGLL,CCL5,PLEK GO:0034110 regulation of homotypic cell-cell adhesion 0.0102684663077413 0.0102684663077413 +1 ALOX12,CD9,DMTN,CCL5 GO:0042401 biogenic amine biosynthetic process 0.0102684663077413 0.0102684663077413 +1 SNCA,ODC1,OAZ1,SAT1 GO:0033631 cell-cell adhesion mediated by integrin 0.010744121308640917 0.010744121308640917 +1 FERMT3,CCL5,ITGB1 GO:0052548 regulation of endopeptidase activity 0.01079120769783165 0.01079120769783165 +1 SNCA,P2RX1,GSN,CDKN2D,GPX1,DAP,ATP2A3,TIMP1,DNAJB6,HMGB1,GAPDH GO:0007269 neurotransmitter secretion 0.010932426643884335 0.010932426643884335 +1 SEPT5,SNCA,P2RX1,RAP1B,STX11,SNAP23,STXBP2 GO:0099643 signal release from synapse 0.010932426643884335 0.010932426643884335 +1 SEPT5,SNCA,P2RX1,RAP1B,STX11,SNAP23,STXBP2 GO:0010762 regulation of fibroblast migration 0.011027268834150514 0.011027268834150514 +1 ITGB3,DMTN,TGFB1,ITGB1 GO:0002685 regulation of leukocyte migration 0.011027268834150514 0.011027268834150514 +1 GP1BA,ITGB3,CD9,MPP1,CCL5,TGFB1,APP,HMGB1,CD99 GO:0009309 amine biosynthetic process 0.011027268834150514 0.011027268834150514 +1 SNCA,ODC1,OAZ1,SAT1 GO:0045806 negative regulation of endocytosis 0.011205561923910172 0.011205561923910172 +1 ITGB3,PACSIN2,TGFB1,HMGB1,SNX3 GO:0030239 myofibril assembly 0.011205561923910172 0.011205561923910172 +1 MYL9,TPM1,WDR1,ACTG1,ITGB1 GO:0051051 negative regulation of transport 0.011511871618618297 0.011511871618618297 +1 ITGB3,SNCA,DMTN,OAZ1,GNB5,PACSIN2,TGFB1,UBAC2,RAP1B,HMGB1,SNX3,GSTO1,SVIP GO:0055002 striated muscle cell development 0.011812674532036799 0.011812674532036799 +1 MYL9,TPM1,WDR1,ACTG1,ITGB1 GO:0150116 regulation of cell-substrate junction organization 0.011812674532036799 0.011812674532036799 +1 ARHGAP6,DMTN,LIMS1,TLN1,ACTG1 GO:0098751 bone cell development 0.011858633887969228 0.011858633887969228 +1 GP9,GP1BA,C6ORF25,FLNA GO:0006595 polyamine metabolic process 0.012091876182351451 0.012091876182351451 +1 ODC1,OAZ1,SAT1 GO:0051146 striated muscle cell differentiation 0.01211577122336086 0.01211577122336086 +1 MYL9,CD9,TPM1,GPX1,WDR1,LMNA,MTPN,ACTG1,ITGB1,G6PD GO:2000116 regulation of cysteine-type endopeptidase activity 0.01229941363449169 0.01229941363449169 +1 SNCA,P2RX1,GSN,CDKN2D,GPX1,DAP,ATP2A3,DNAJB6,HMGB1 GO:1903076 regulation of protein localization to plasma membrane 0.012426845596673125 0.012426845596673125 +1 PGRMC1,ACTB,ITGB1,LDLRAP1,SQSTM1,AP2M1 GO:0043547 positive regulation of GTPase activity 0.012657163751493167 0.012657163751493167 +1 ARHGAP6,RGS10,RSU1,CCL5,LIMS1,GNB5,TAX1BP3,RABGAP1L,ITGB1,GNAS GO:0048144 fibroblast proliferation 0.012883526459101501 0.012883526459101501 +1 ITGB3,GPX1,TGFB1,SOD2,FTH1,BRK1 GO:0043270 positive regulation of monoatomic ion transport 0.012883526459101501 0.012883526459101501 +1 SCN1B,SNCA,P2RX1,CCL5,FHL1,TMSB4X,FLNA,GSTO1,G6PD GO:0055070 copper ion homeostasis 0.013685277423479855 0.013685277423479855 +1 ANKRD9,APP,ARF1 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 0.013685277423479855 0.013685277423479855 +1 GPX1,SOD2,HSPB1 GO:0051580 regulation of neurotransmitter uptake 0.013685277423479855 0.013685277423479855 +1 ITGB3,SNCA,ITGB1 GO:1900242 regulation of synaptic vesicle endocytosis 0.013685277423479855 0.013685277423479855 +1 ACTB,ACTG1,AP2M1 GO:0006936 muscle contraction 0.01438878766575094 0.01438878766575094 +1 MYL9,SCN1B,CTTN,TPM1,TPM4,P2RX1,GSN,MYL6,FLNA,GSTO1,TPM3 GO:0007043 cell-cell junction assembly 0.01484952974371174 0.01484952974371174 +1 CLDN5,ESAM,CD9,ACTB,WDR1,TLN1,ACTG1 GO:0071677 positive regulation of mononuclear cell migration 0.015126680992196018 0.015126680992196018 +1 ITGB3,CCL5,TGFB1,APP,HMGB1 GO:0006837 serotonin transport 0.015615885740127025 0.015615885740127025 +1 ITGB3,SNCA,P2RX1 GO:0006904 vesicle docking involved in exocytosis 0.01574137352094473 0.01574137352094473 +1 SCFD2,RAB10,STXBP2,PLEK GO:0045214 sarcomere organization 0.01574137352094473 0.01574137352094473 +1 TPM1,WDR1,ACTG1,ITGB1 GO:0042177 negative regulation of protein catabolic process 0.016226205320309686 0.016226205320309686 +1 SNCA,CTSA,TIMP1,FLNA,SNX3,SVIP GO:0016125 sterol metabolic process 0.016861262444794307 0.016861262444794307 +1 FAXDC2,CYB5R1,APP,LDLRAP1,ACADVL,CYB5R3,G6PD GO:0090201 negative regulation of release of cytochrome c from mitochondria 0.017623963704696183 0.017623963704696183 +1 CLU,GPX1,LMNA GO:0021762 substantia nigra development 0.018264780512647235 0.018264780512647235 +1 YWHAH,ACTB,DYNLL1,G6PD GO:0050765 negative regulation of phagocytosis 0.019997837210667654 0.019997837210667654 +1 TGFB1,HMGB1,SNX3 GO:0034314 Arp2/3 complex-mediated actin nucleation 0.02077439310478359 0.02077439310478359 +1 ARPC1B,ARPC5,ARF1,BRK1 GO:1903034 regulation of response to wounding 0.02084768926179917 0.02084768926179917 +1 GP1BA,ALOX12,CD9,DMTN,ACTG1,FLNA,ITGB1 GO:0050808 synapse organization 0.02101537265382135 0.02101537265382135 +1 ITGB3,CTTN,SNCA,PGRMC1,ACTN1,ACTB,APP,RAP1B,ACTG1,DBNL,FLNA,ARF1,ITGB1 GO:0051702 biological process involved in interaction with symbiont 0.02101537265382135 0.02101537265382135 +1 PF4,GPX1,CCL5,GAPDH,VAPA,STOM GO:0001952 regulation of cell-matrix adhesion 0.022738159772816312 0.022738159772816312 +1 ITGB3,ARHGAP6,DMTN,LIMS1,TLN1,ACTG1 GO:0032272 negative regulation of protein polymerization 0.02317036190919418 0.02317036190919418 +1 SNCA,DMTN,GSN,TMSB4X,MTPN GO:0140056 organelle localization by membrane tethering 0.02317036190919418 0.02317036190919418 +1 SCFD2,RAB10,STX11,STXBP2,PLEK GO:0006979 response to oxidative stress 0.024165619605941557 0.024165619605941557 +1 PTGS1,SNCA,TPM1,PDLIM1,GPX1,PRDX6,APP,PYCR2,GPX4,SOD2,G6PD,HSPB1 GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 0.024206621999743824 0.024206621999743824 +1 PF4,PPBP,HIST1H2BJ,HIST1H2BK,GAPDH GO:1900273 positive regulation of long-term synaptic potentiation 0.024297773946866247 0.024297773946866247 +1 NRGN,APP,SQSTM1 GO:2000178 negative regulation of neural precursor cell proliferation 0.024297773946866247 0.024297773946866247 +1 ILK,TGFB1,SPINT2 GO:1902904 negative regulation of supramolecular fiber organization 0.025471558071869013 0.025471558071869013 +1 CLU,ARHGAP6,SNCA,DMTN,GSN,TMSB4X,MTPN GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.025951726164452217 0.025951726164452217 +1 SNCA,P2RX1,GSN,DAP,ATP2A3,HMGB1 GO:0099623 regulation of cardiac muscle cell membrane repolarization 0.02669899735679711 0.02669899735679711 +1 SCN1B,WDR1,FLNA GO:0050804 modulation of chemical synaptic transmission 0.02669899735679711 0.02669899735679711 +1 SEPT5,NRGN,CA2,SNCA,P2RX1,YWHAH,PACSIN2,APP,RAP1B,ARF1,ITGB1,SQSTM1,GLUL GO:0010811 positive regulation of cell-substrate adhesion 0.02669899735679711 0.02669899735679711 +1 ITGB3,DMTN,ILK,RSU1,LIMS1,FLNA GO:0099177 regulation of trans-synaptic signaling 0.026816654774527434 0.026816654774527434 +1 SEPT5,NRGN,CA2,SNCA,P2RX1,YWHAH,PACSIN2,APP,RAP1B,ARF1,ITGB1,SQSTM1,GLUL GO:0031647 regulation of protein stability 0.02732105555467322 0.02732105555467322 +1 CLU,SNCA,CTSA,GSN,UBL4A,MFSD1,LMNA,SERF2,FLNA,GAPDH GO:0048145 regulation of fibroblast proliferation 0.0295477355212304 0.0295477355212304 +1 ITGB3,TGFB1,SOD2,FTH1,BRK1 GO:0033627 cell adhesion mediated by integrin 0.0295477355212304 0.0295477355212304 +1 ITGA2B,ITGB3,FERMT3,CCL5,ITGB1 GO:0061041 regulation of wound healing 0.030280539262955153 0.030280539262955153 +1 GP1BA,ALOX12,CD9,DMTN,ACTG1,ITGB1 GO:1904375 regulation of protein localization to cell periphery 0.031115322601062683 0.031115322601062683 +1 PGRMC1,ACTB,ITGB1,LDLRAP1,SQSTM1,AP2M1 GO:1990266 neutrophil migration 0.031115322601062683 0.031115322601062683 +1 PF4,PPBP,MPP1,CCL5,WDR1,CD99 GO:0010466 negative regulation of peptidase activity 0.031115322601062683 0.031115322601062683 +1 SNCA,CDKN2D,GPX1,TIMP1,DNAJB6,APP,SPINT2,GAPDH GO:0030225 macrophage differentiation 0.031115322601062683 0.031115322601062683 +1 PF4,TGFB1,APP,EIF2AK1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 0.03206859253129402 0.03206859253129402 +1 CHMP6,LEPROT,TMEM50A GO:0010632 regulation of epithelial cell migration 0.03283605497737428 0.03283605497737428 +1 SPARC,ITGB3,RAB11A,TMSB4X,ADIPOR1,HMGB1,GLUL,HSPB1 GO:0140694 non-membrane-bounded organelle assembly 0.03283605497737428 0.03283605497737428 +1 MYL9,TUBB1,TPM1,GSN,CHMP6,RAB11A,WDR1,ACTG1,DBNL,FLNA,ITGB1 GO:0001836 release of cytochrome c from mitochondria 0.03283605497737428 0.03283605497737428 +1 CLU,GPX1,LMNA,SOD2 GO:0097581 lamellipodium organization 0.03283605497737428 0.03283605497737428 +1 CTTN,DMTN,PARVB,ITGB1,BRK1 GO:0015850 organic hydroxy compound transport 0.03318167066651345 0.03318167066651345 +1 ITGB3,CLU,SNCA,ABCC3,P2RX1,ACTB,LAMTOR1,LDLRAP1,VAPA GO:2000177 regulation of neural precursor cell proliferation 0.033528016491732426 0.033528016491732426 +1 ILK,TGFB1,NAP1L1,ITGB1,SPINT2 GO:0033157 regulation of intracellular protein transport 0.03362348461762821 0.03362348461762821 +1 DMTN,OAZ1,LEPROT,TGFB1,UBAC2,FLNA,STOM,SVIP GO:0032386 regulation of intracellular transport 0.034183040718697814 0.034183040718697814 +1 DMTN,OAZ1,LEPROT,TGFB1,UBAC2,FLNA,SNX3,LDLRAP1,STOM,SVIP GO:1901879 regulation of protein depolymerization 0.03475096192200541 0.03475096192200541 +1 DMTN,GSN,WDR1,MTPN,PLEK GO:2001234 negative regulation of apoptotic signaling pathway 0.03499342605948778 0.03499342605948778 +1 PF4,CLU,CTTN,CDKN2D,GPX1,LMNA,SOD2,HSPB1 GO:0007032 endosome organization 0.03600113237489271 0.03600113237489271 +1 CHMP6,LAMTOR1,RAB11A,SNX3,SQSTM1 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 0.03693557441734123 0.03693557441734123 +1 GPX1,SOD2,HSPB1 GO:0072659 protein localization to plasma membrane 0.03708998222161334 0.03708998222161334 +1 PGRMC1,ACTB,RAB11A,RAB10,FLNA,ITGB1,LDLRAP1,SQSTM1,AP2M1 GO:0090257 regulation of muscle system process 0.03709136832092698 0.03709136832092698 +1 MYL9,CTTN,TPM1,P2RX1,LMNA,MTPN,GSTO1,G6PD GO:0045185 maintenance of protein location 0.03709136832092698 0.03709136832092698 +1 GSN,TMSB4X,SRGN,FLNA,SKP1 GO:0045765 regulation of angiogenesis 0.03747283345764014 0.03747283345764014 +1 SPARC,CLDN5,PF4,ITGB3,PKM,ITGB1,GLUL,HTATIP2,HSPB1 GO:0032387 negative regulation of intracellular transport 0.03844569946136037 0.03844569946136037 +1 DMTN,UBAC2,SNX3,SVIP GO:0001738 morphogenesis of a polarized epithelium 0.03844569946136037 0.03844569946136037 +1 DAAM1,ACTB,WDR1,RAB10,ACTG1 GO:0034764 positive regulation of transmembrane transport 0.03844569946136037 0.03844569946136037 +1 CA2,SNCA,P2RX1,TMSB4X,FLNA,ITGB1,GSTO1,G6PD GO:0044000 movement in host 0.03844569946136037 0.03844569946136037 +1 ITGB3,GSN,CHMP6,HMGB1,ITGB1,SNX3,VAPA GO:1901342 regulation of vasculature development 0.039918225840560095 0.039918225840560095 +1 SPARC,CLDN5,PF4,ITGB3,PKM,ITGB1,GLUL,HTATIP2,HSPB1 GO:0016126 sterol biosynthetic process 0.04021265743953201 0.04021265743953201 +1 FAXDC2,CYB5R1,CYB5R3,G6PD GO:1901617 organic hydroxy compound biosynthetic process 0.04057617091215644 0.04057617091215644 +1 FAXDC2,ALOX12,SNCA,CYB5R1,ASAH1,CYB5R3,PLEK,G6PD GO:1901222 regulation of NIK/NF-kappaB signaling 0.040580577412592696 0.040580577412592696 +1 ILK,LIMS1,TMSB4X,APP,ADIPOR1 GO:0006576 biogenic amine metabolic process 0.040580577412592696 0.040580577412592696 +1 SNCA,ODC1,OAZ1,SAT1,MTPN GO:0002274 myeloid leukocyte activation 0.04130366000351639 0.04130366000351639 +1 CLU,SNCA,CCL5,TGFB1,APP,HMGB1,SNAP23,STXBP2 GO:0007265 Ras protein signal transduction 0.04143709318940049 0.04143709318940049 +1 ARHGAP6,GRAP2,TAX1BP3,RAP1B,DBNL,ITGB1,SQSTM1,ARHGDIB,BRK1,RAB4A GO:0071870 cellular response to catecholamine stimulus 0.041467393744859374 0.041467393744859374 +1 SNCA,GNB5,APP,FLNA,GNAS GO:0071868 cellular response to monoamine stimulus 0.041467393744859374 0.041467393744859374 +1 SNCA,GNB5,APP,FLNA,GNAS GO:0070252 actin-mediated cell contraction 0.041467393744859374 0.041467393744859374 +1 SCN1B,TPM1,GSN,MYL6,FLNA GO:2001257 regulation of cation channel activity 0.041467393744859374 0.041467393744859374 +1 GNB5,FKBP1A,TMSB4X,ITGB1,GSTO1,STOM GO:0090330 regulation of platelet aggregation 0.041467393744859374 0.041467393744859374 +1 ALOX12,CD9,DMTN GO:2001056 positive regulation of cysteine-type endopeptidase activity 0.041467393744859374 0.041467393744859374 +1 SNCA,P2RX1,GSN,DAP,ATP2A3,HMGB1 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 0.041467393744859374 0.041467393744859374 +1 CLU,CDKN2D,GPX1,SOD2,HSPB1 GO:0099173 postsynapse organization 0.04210517295861097 0.04210517295861097 +1 ITGB3,CTTN,ACTN1,ACTB,ACTG1,DBNL,ARF1 GO:0097529 myeloid leukocyte migration 0.042376329311810186 0.042376329311810186 +1 PF4,PPBP,CD9,MPP1,CCL5,WDR1,HMGB1,CD99 GO:0042552 myelination 0.042376329311810186 0.042376329311810186 +1 CLDN5,CLU,CD9,ILK,TGFB1,RNF10 GO:0032760 positive regulation of tumor necrosis factor production 0.042845458412627206 0.042845458412627206 +1 PF4,CLU,APP,HMGB1,HSPB1 GO:0034341 response to type II interferon 0.04362070498827734 0.04362070498827734 +1 SNCA,GSN,CCL5,ACTG1,STXBP2,GAPDH GO:0010039 response to iron ion 0.044770895469912655 0.044770895469912655 +1 SNCA,SLC40A1,G6PD GO:0008366 axon ensheathment 0.0447854937989941 0.0447854937989941 +1 CLDN5,CLU,CD9,ILK,TGFB1,RNF10 GO:0007272 ensheathment of neurons 0.0447854937989941 0.0447854937989941 +1 CLDN5,CLU,CD9,ILK,TGFB1,RNF10 GO:0044829 positive regulation by host of viral genome replication 0.04556684382559478 0.04556684382559478 +1 VAPA,STOM GO:0070862 negative regulation of protein exit from endoplasmic reticulum 0.04556684382559478 0.04556684382559478 +1 UBAC2,SVIP GO:0071869 response to catecholamine 0.04570473949670286 0.04570473949670286 +1 SNCA,GNB5,APP,FLNA,GNAS GO:0071867 response to monoamine 0.04570473949670286 0.04570473949670286 +1 SNCA,GNB5,APP,FLNA,GNAS GO:0016197 endosomal transport 0.04644571457854348 0.04644571457854348 +1 CHMP6,LEPROT,LAMTOR1,RAB11A,RAB10,TMEM50A,SNX3,SQSTM1 GO:0032231 regulation of actin filament bundle assembly 0.04707523290059008 0.04707523290059008 +1 ARHGAP6,TPM1,ACTG1,FLNA,PLEK GO:0045785 positive regulation of cell adhesion 0.04707523290059008 0.04707523290059008 +1 GP1BA,ITGB3,DMTN,TPM1,ILK,RSU1,CCL5,LIMS1,ACTB,TGFB1,FLNA,HMGB1 GO:0060306 regulation of membrane repolarization 0.04754184988243117 0.04754184988243117 +1 SCN1B,WDR1,FLNA GO:0010634 positive regulation of epithelial cell migration 0.048181770727127864 0.048181770727127864 +1 SPARC,ITGB3,RAB11A,TMSB4X,HMGB1,HSPB1 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 0.048457809277487864 0.048457809277487864 +1 PF4,CLU,APP,HMGB1,HSPB1 GO:1905477 positive regulation of protein localization to membrane 0.048457809277487864 0.048457809277487864 +1 PGRMC1,TGFB1,ITGB1,SQSTM1,STOM GO:0010595 positive regulation of endothelial cell migration 0.048457809277487864 0.048457809277487864 +1 SPARC,ITGB3,TMSB4X,HMGB1,HSPB1 GO:0002687 positive regulation of leukocyte migration 0.04931250989113863 0.04931250989113863 +1 ITGB3,CCL5,TGFB1,APP,HMGB1,CD99 REAC:R-HSA-76002 Platelet activation, signaling and aggregation 7.963235032661613e-17 7.963235032661613e-17 +1 GP9,ITGA2B,LY6G6F,SPARC,GNG11,PF4,GP1BA,ITGB3,CLEC1B,CLU,PPBP,F13A1,C6ORF25,CD9,ACTN1,FERMT3,MGLL,TAGLN2,GNB5,TUBA4A,CYB5R1,TIMP1,TMSB4X,WDR1,APP,TLN1,SRGN,RAP1B,FLNA,STXBP2,MAGED2,PLEK REAC:R-HSA-114608 Platelet degranulation 7.963235032661613e-17 7.963235032661613e-17 +1 ITGA2B,LY6G6F,SPARC,PF4,ITGB3,CLU,PPBP,F13A1,CD9,ACTN1,FERMT3,TAGLN2,TUBA4A,CYB5R1,TIMP1,TMSB4X,WDR1,APP,TLN1,SRGN,FLNA,STXBP2,MAGED2,PLEK REAC:R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 1.399951566321132e-16 1.399951566321132e-16 +1 ITGA2B,LY6G6F,SPARC,PF4,ITGB3,CLU,PPBP,F13A1,CD9,ACTN1,FERMT3,TAGLN2,TUBA4A,CYB5R1,TIMP1,TMSB4X,WDR1,APP,TLN1,SRGN,FLNA,STXBP2,MAGED2,PLEK REAC:R-HSA-446353 Cell-extracellular matrix interactions 4.510061131369075e-10 4.510061131369075e-10 +1 ILK,ACTN1,PARVB,RSU1,LIMS1,ACTB,ACTG1,FLNA,ITGB1 REAC:R-HSA-195258 RHO GTPase Effectors 1.3033369342858539e-9 1.3033369342858539e-9 +1 MYL9,TUBA8,TUBB1,CTTN,HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,DAAM1,TUBA1C,H2AFJ,YWHAH,MYL6,H3F3A,TUBA4A,ARPC1B,ACTB,TAX1BP3,DYNLL1,ARPC5,ACTG1,FLNA,ITGB1,TUBB4B,BRK1,DIAPH1 REAC:R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 1.4038612510567085e-7 1.4038612510567085e-7 +1 TUBA8,TUBB1,TUBA1C,YWHAH,TUBA4A,ACTB,RAB11A,RAB10,ACTG1,SNAP23,TUBB4B,RAB4A REAC:R-HSA-6798695 Neutrophil degranulation 2.3506757496022592e-7 2.3506757496022592e-7 +1 PPBP,PGRMC1,CTSA,P2RX1,GSN,CAPN1,PRDX6,LAMTOR1,GLA,DYNLL1,ARPC5,ASAH1,PYGL,PKM,RAP1B,RAB10,DBNL,HMGB1,RAB37,SNAP23,TUBB4B,FTH1,VAPA,CYB5R3,STOM,HLA-C,DIAPH1,SVIP REAC:R-HSA-446728 Cell junction organization 0.000017452790681216157 0.000017452790681216157 +1 CLDN5,ILK,ACTN1,PARVB,RSU1,CD151,LIMS1,ACTB,ACTG1,FLNA,ITGB1 REAC:R-HSA-373760 L1CAM interactions 0.000033460449212538533 0.000033460449212538533 +1 ITGA2B,ITGB3,SCN1B,TUBA8,TUBB1,TUBA1C,TUBA4A,ACTB,ACTG1,ITGB1,TUBB4B,AP2M1 REAC:R-HSA-5626467 RHO GTPases activate IQGAPs 0.000039530138418852866 0.000039530138418852866 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,ACTB,ACTG1,TUBB4B REAC:R-HSA-437239 Recycling pathway of L1 0.00004868811585879276 0.00004868811585879276 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,ACTB,ACTG1,TUBB4B,AP2M1 REAC:R-HSA-190828 Gap junction trafficking 0.00005379898747761936 0.00005379898747761936 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,ACTB,ACTG1,TUBB4B,AP2M1 REAC:R-HSA-157858 Gap junction trafficking and regulation 0.00005944758165490418 0.00005944758165490418 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,ACTB,ACTG1,TUBB4B,AP2M1 REAC:R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 0.00015861795561201086 0.00015861795561201086 +1 ITGA2B,PF4,GP1BA,MYL9,HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-445355 Smooth Muscle Contraction 0.0002014025439807289 0.0002014025439807289 +1 MYL9,TPM1,TPM4,MYL6,MYL12A,TLN1,TPM3 REAC:R-HSA-1500931 Cell-Cell communication 0.0002469197781184751 0.0002469197781184751 +1 CLDN5,ILK,ACTN1,PARVB,RSU1,CD151,LIMS1,ACTB,ACTG1,FLNA,ITGB1 REAC:R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.0003627238928352279 0.0003627238928352279 +1 TUBA8,TUBB1,TUBA1C,CHMP6,TUBA4A,TUBB4B REAC:R-HSA-9609646 HCMV Infection 0.0003627238928352279 0.0003627238928352279 +1 TUBA8,TUBB1,HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,TUBA1C,CHMP6,TUBA4A,DYNLL1,ITGB1,TUBB4B REAC:R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.00038877546234803595 0.00038877546234803595 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,ACTB,TUBB4B REAC:R-HSA-9609690 HCMV Early Events 0.00038877546234803595 0.00038877546234803595 +1 TUBA8,TUBB1,HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,TUBA1C,TUBA4A,DYNLL1,ITGB1,TUBB4B REAC:R-HSA-5663220 RHO GTPases Activate Formins 0.00038877546234803595 0.00038877546234803595 +1 TUBA8,TUBB1,DAAM1,TUBA1C,TUBA4A,ACTB,DYNLL1,ACTG1,ITGB1,TUBB4B,DIAPH1 REAC:R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 0.00039122230174230626 0.00039122230174230626 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-190872 Transport of connexons to the plasma membrane 0.0004892531548781351 0.0004892531548781351 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.0004990986557137482 0.0004990986557137482 +1 ITGA2B,ITGB3,ACTB,TLN1,RAP1B,ACTG1 REAC:R-HSA-5625740 RHO GTPases activate PKNs 0.0005494110528725212 0.0005494110528725212 +1 MYL9,HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,YWHAH,MYL6,H3F3A REAC:R-HSA-76009 Platelet Aggregation (Plug Formation) 0.000734165995060133 0.000734165995060133 +1 GP9,ITGA2B,GP1BA,ITGB3,TLN1,RAP1B REAC:R-HSA-2132295 MHC class II antigen presentation 0.000734165995060133 0.000734165995060133 +1 TUBA8,TUBB1,CTSA,TUBA1C,TUBA4A,DYNLL1,AP1B1,ARF1,TUBB4B,AP2M1 REAC:R-HSA-5674135 MAP2K and MAPK activation 0.0007706125511353859 0.0007706125511353859 +1 ITGA2B,ITGB3,ACTB,TLN1,RAP1B,ACTG1 REAC:R-HSA-389977 Post-chaperonin tubulin folding pathway 0.0007706125511353859 0.0007706125511353859 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-9656223 Signaling by RAF1 mutants 0.000870903159992723 0.000870903159992723 +1 ITGA2B,ITGB3,ACTB,TLN1,RAP1B,ACTG1 REAC:R-HSA-9645723 Diseases of programmed cell death 0.0009812083666340108 0.0009812083666340108 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,CAPN1,H2AFJ,H3F3A,APP,SOD2 REAC:R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 0.0010732577119925916 0.0010732577119925916 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.0011336285135092653 0.0011336285135092653 +1 ITGA2B,ITGB3,TLN1,RAP1B REAC:R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.0012385620145826744 0.0012385620145826744 +1 ITGA2B,ITGB3,ACTB,TLN1,RAP1B,ACTG1 REAC:R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.0012385620145826744 0.0012385620145826744 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-9646399 Aggrephagy 0.0012385620145826744 0.0012385620145826744 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,DYNLL1,TUBB4B REAC:R-HSA-977225 Amyloid fiber formation 0.0012385620145826744 0.0012385620145826744 +1 HIST1H2AC,SNCA,HIST1H2BJ,HIST1H2BD,HIST1H2BK,GSN,H3F3A,ITM2B,APP REAC:R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.0012385620145826744 0.0012385620145826744 +1 ITGA2B,ITGB3,ACTB,TLN1,LMNA,RAP1B,ACTG1 REAC:R-HSA-9649948 Signaling downstream of RAS mutants 0.0012385620145826744 0.0012385620145826744 +1 ITGA2B,ITGB3,ACTB,TLN1,RAP1B,ACTG1 REAC:R-HSA-6802949 Signaling by RAS mutants 0.0012385620145826744 0.0012385620145826744 +1 ITGA2B,ITGB3,ACTB,TLN1,RAP1B,ACTG1 REAC:R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.0012385620145826744 0.0012385620145826744 +1 ITGA2B,ITGB3,ACTB,TLN1,RAP1B,ACTG1 REAC:R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.0012385620145826744 0.0012385620145826744 +1 ITGA2B,ITGB3,TLN1,RAP1B REAC:R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.0012385620145826744 0.0012385620145826744 +1 TUBB1,TUBA1C,TUBA4A,ACTB,TUBB4B REAC:R-HSA-2682334 EPH-Ephrin signaling 0.001524266224334975 0.001524266224334975 +1 MYL9,MYL6,ARPC1B,ACTB,ARPC5,MYL12A,ACTG1,AP2M1 REAC:R-HSA-390466 Chaperonin-mediated protein folding 0.0016188172398984913 0.0016188172398984913 +1 GNG11,TUBA8,TUBB1,TUBA1C,GNB5,TUBA4A,ACTB,TUBB4B REAC:R-HSA-391251 Protein folding 0.0025829167209520825 0.0025829167209520825 +1 GNG11,TUBA8,TUBB1,TUBA1C,GNB5,TUBA4A,ACTB,TUBB4B REAC:R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.002768574869759585 0.002768574869759585 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,DYNLL1,TUBB4B REAC:R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 0.003084316653995031 0.003084316653995031 +1 ARPC1B,ACTB,ARPC5,ACTG1,BRK1 REAC:R-HSA-6807878 COPI-mediated anterograde transport 0.0032412708992724014 0.0032412708992724014 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,DYNLL1,ARF1,TMED3,TUBB4B REAC:R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand 0.003925516277359702 0.003925516277359702 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,DYNLL1,TUBB4B REAC:R-HSA-9663891 Selective autophagy 0.003925516277359702 0.003925516277359702 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,DYNLL1,SQSTM1,TUBB4B REAC:R-HSA-5627123 RHO GTPases activate PAKs 0.004005394776944784 0.004005394776944784 +1 MYL9,CTTN,MYL6,FLNA REAC:R-HSA-1632852 Macroautophagy 0.004055096143491854 0.004055096143491854 +1 TUBA8,TUBB1,TUBA1C,CHMP6,TUBA4A,LAMTOR1,DYNLL1,SQSTM1,TUBB4B REAC:R-HSA-190861 Gap junction assembly 0.0041123148566748835 0.0041123148566748835 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 0.0041123148566748835 0.0041123148566748835 +1 TALDO1,RAP1B,SOD2,ARF1,GSTO1 REAC:R-HSA-6802957 Oncogenic MAPK signaling 0.004240171859720032 0.004240171859720032 +1 ITGA2B,ITGB3,ACTB,TLN1,LMNA,RAP1B,ACTG1 REAC:R-HSA-912446 Meiotic recombination 0.00600077431554831 0.00600077431554831 +1 HIST1H2AC,HIST1H2BJ,MLH3,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-73728 RNA Polymerase I Promoter Opening 0.0060533720305469265 0.0060533720305469265 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-5334118 DNA methylation 0.006781848630893004 0.006781848630893004 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.006781848630893004 0.006781848630893004 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-196025 Formation of annular gap junctions 0.006781848630893004 0.006781848630893004 +1 ACTB,ACTG1,AP2M1 REAC:R-HSA-430116 GP1b-IX-V activation signalling 0.006781848630893004 0.006781848630893004 +1 GP9,GP1BA,FLNA REAC:R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.006783920249239787 0.006783920249239787 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A,ACTB REAC:R-HSA-9612973 Autophagy 0.007543975737381783 0.007543975737381783 +1 TUBA8,TUBB1,TUBA1C,CHMP6,TUBA4A,LAMTOR1,DYNLL1,SQSTM1,TUBB4B REAC:R-HSA-9670095 Inhibition of DNA recombination at telomere 0.0075729718138408415 0.0075729718138408415 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 0.0075729718138408415 0.0075729718138408415 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-354192 Integrin signaling 0.007628157556303989 0.007628157556303989 +1 ITGA2B,ITGB3,TLN1,RAP1B REAC:R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 0.007664471404056832 0.007664471404056832 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-427359 SIRT1 negatively regulates rRNA expression 0.007895366943236814 0.007895366943236814 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-190873 Gap junction degradation 0.008016224560109043 0.008016224560109043 +1 ACTB,ACTG1,AP2M1 REAC:R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.008328992813538636 0.008328992813538636 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.008828611842381777 0.008828611842381777 +1 TUBA8,TUBB1,TUBA1C,CHMP6,TUBA4A,TUBB4B REAC:R-HSA-9020591 Interleukin-12 signaling 0.008828611842381777 0.008828611842381777 +1 TALDO1,RAP1B,SOD2,ARF1,GSTO1 REAC:R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.010447175683468604 0.010447175683468604 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,ARF1,TMED3,TUBB4B REAC:R-HSA-2299718 Condensation of Prophase Chromosomes 0.01046291612143182 0.01046291612143182 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-9710421 Defective pyroptosis 0.01046291612143182 0.01046291612143182 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-212300 PRC2 methylates histones and DNA 0.01046291612143182 0.01046291612143182 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-8856688 Golgi-to-ER retrograde transport 0.012396927200610471 0.012396927200610471 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,DYNLL1,ARF1,TMED3,TUBB4B REAC:R-HSA-171306 Packaging Of Telomere Ends 0.012396927200610471 0.012396927200610471 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.012396927200610471 0.012396927200610471 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-157118 Signaling by NOTCH 0.012396927200610471 0.012396927200610471 +1 PTCRA,HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A,ATP2A3,TACC3,RBX1,SKP1 REAC:R-HSA-438064 Post NMDA receptor activation events 0.012396927200610471 0.012396927200610471 +1 NRGN,TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-8878171 Transcriptional regulation by RUNX1 0.012763082414917776 0.012763082414917776 +1 ITGA2B,CLDN5,PF4,GP1BA,MYL9,HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-9700206 Signaling by ALK in cancer 0.012763082414917776 0.012763082414917776 +1 TPM4,SQSTM1,RBX1,TPM3,SKP1 REAC:R-HSA-75892 Platelet Adhesion to exposed collagen 0.012763082414917776 0.012763082414917776 +1 GP9,GP1BA,ITGB1 REAC:R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.012763082414917776 0.012763082414917776 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A,ACTB REAC:R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.012763082414917776 0.012763082414917776 +1 TPM4,SQSTM1,RBX1,TPM3,SKP1 REAC:R-HSA-5620924 Intraflagellar transport 0.013601739065295703 0.013601739065295703 +1 TUBB1,TUBA1C,TUBA4A,DYNLL1,TUBB4B REAC:R-HSA-110331 Cleavage of the damaged purine 0.014225520526368465 0.014225520526368465 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine 0.014225520526368465 0.014225520526368465 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-73927 Depurination 0.014225520526368465 0.014225520526368465 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-9651496 Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 0.014412511585434976 0.014412511585434976 +1 GP9,GP1BA,TPST2 REAC:R-HSA-1912422 Pre-NOTCH Expression and Processing 0.014412511585434976 0.014412511585434976 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A,ATP2A3 REAC:R-HSA-9671793 Diseases of hemostasis 0.014412511585434976 0.014412511585434976 +1 GP9,GP1BA,TPST2 REAC:R-HSA-447115 Interleukin-12 family signaling 0.01608971775501191 0.01608971775501191 +1 TALDO1,RAP1B,SOD2,ARF1,GSTO1 REAC:R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.016121645538334662 0.016121645538334662 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,CDKN2D,H2AFJ,H3F3A REAC:R-HSA-1474165 Reproduction 0.016121645538334662 0.016121645538334662 +1 HIST1H2AC,CD9,HIST1H2BJ,MLH3,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-5610787 Hedgehog 'off' state 0.01680872556119143 0.01680872556119143 +1 TUBB1,TUBA1C,TUBA4A,TUBB4B,RBX1,GNAS,SKP1 REAC:R-HSA-9012999 RHO GTPase cycle 0.018162484804341617 0.018162484804341617 +1 ARHGAP6,TPM4,ACTN1,DAAM1,ACTB,LAMTOR1,RBBP6,ACTG1,ITGB1,SNAP23,ARHGDIB,UBXN11,BRK1,STOM,TPM3,DIAPH1 REAC:R-HSA-195721 Signaling by WNT 0.01822992439385733 0.01822992439385733 +1 GNG11,HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,DAAM1,H2AFJ,GNB5,H3F3A,SNX3,RBX1,AP2M1,SKP1 REAC:R-HSA-73928 Depyrimidination 0.018390112951433456 0.018390112951433456 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-983189 Kinesins 0.018390112951433456 0.018390112951433456 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 0.018390112951433456 0.018390112951433456 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-110329 Cleavage of the damaged pyrimidine 0.018390112951433456 0.018390112951433456 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-8939211 ESR-mediated signaling 0.01851978283037962 0.01851978283037962 +1 GNG11,HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,GNB5,H3F3A,USF2,HSPB1 REAC:R-HSA-1500620 Meiosis 0.018823783247249162 0.018823783247249162 +1 HIST1H2AC,HIST1H2BJ,MLH3,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-73929 Base-Excision Repair, AP Site Formation 0.019305241040907337 0.019305241040907337 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.02012218830701651 0.02012218830701651 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.02012218830701651 0.02012218830701651 +1 NRGN,TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.020569464855350366 0.020569464855350366 +1 UBL4A,APP,VAPA REAC:R-HSA-392851 Prostacyclin signalling through prostacyclin receptor 0.020569464855350366 0.020569464855350366 +1 GNG11,GNB5,GNAS REAC:R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 0.021574346029014205 0.021574346029014205 +1 GP9,PF4,GP1BA,F13A1 REAC:R-HSA-73772 RNA Polymerase I Promoter Escape 0.021635613442315044 0.021635613442315044 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.021635613442315044 0.021635613442315044 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-199977 ER to Golgi Anterograde Transport 0.022046677117880706 0.022046677117880706 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,DYNLL1,ARF1,TMED3,TUBB4B REAC:R-HSA-8873719 RAB geranylgeranylation 0.022046677117880706 0.022046677117880706 +1 RAB11A,RAB10,RAB32,RAB37,RAB4A REAC:R-HSA-2559580 Oxidative Stress Induced Senescence 0.022059490522703073 0.022059490522703073 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,CDKN2D,H2AFJ,H3F3A REAC:R-HSA-445144 Signal transduction by L1 0.022059490522703073 0.022059490522703073 +1 ITGA2B,ITGB3,ITGB1 REAC:R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0.022059490522703073 0.022059490522703073 +1 AP1B1,ARF1,AP2M1 REAC:R-HSA-3928662 EPHB-mediated forward signaling 0.022059490522703073 0.022059490522703073 +1 ARPC1B,ACTB,ARPC5,ACTG1 REAC:R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.022574657941360706 0.022574657941360706 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-9013423 RAC3 GTPase cycle 0.0236296620463197 0.0236296620463197 +1 ARHGAP6,LAMTOR1,ITGB1,SNAP23,ARHGDIB,BRK1 REAC:R-HSA-449147 Signaling by Interleukins 0.023772497560823384 0.023772497560823384 +1 F13A1,CCL5,TIMP1,TALDO1,APP,PTPN18,RAP1B,SOD2,ARF1,HMGB1,ITGB1,STXBP2,SQSTM1,GSTO1,RBX1,SKP1 REAC:R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.02439953031426287 0.02439953031426287 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,DYNLL1,TUBB4B REAC:R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 0.02439953031426287 0.02439953031426287 +1 CAPN1,APP,SOD2 REAC:R-HSA-8863678 Neurodegenerative Diseases 0.02439953031426287 0.02439953031426287 +1 CAPN1,APP,SOD2 REAC:R-HSA-9035034 RHOF GTPase cycle 0.02504380863611751 0.02504380863611751 +1 ACTN1,ACTB,SNAP23,DIAPH1 REAC:R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.027084971088541326 0.027084971088541326 +1 GNG11,GNB5,RAB11A,GNAS REAC:R-HSA-9634597 GPER1 signaling 0.029225871921135918 0.029225871921135918 +1 GNG11,GNB5,ITGB1,GNAS REAC:R-HSA-397014 Muscle contraction 0.0313183512692464 0.0313183512692464 +1 MYL9,SCN1B,TPM1,TPM4,MYL6,ATP2A3,MYL12A,TLN1,TPM3 REAC:R-HSA-199992 trans-Golgi Network Vesicle Budding 0.03265762615764876 0.03265762615764876 +1 APP,AP1B1,ARF1,SNAP23,FTH1 REAC:R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.033772631410156705 0.033772631410156705 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-5578749 Transcriptional regulation by small RNAs 0.033772631410156705 0.033772631410156705 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.033772631410156705 0.033772631410156705 +1 CAPN1,APP,SOD2 REAC:R-HSA-774815 Nucleosome assembly 0.033772631410156705 0.033772631410156705 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-3000178 ECM proteoglycans 0.03728362285165274 0.03728362285165274 +1 ITGA2B,SPARC,ITGB3,APP,ITGB1 REAC:R-HSA-427413 NoRC negatively regulates rRNA expression 0.03798922914820772 0.03798922914820772 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-163685 Integration of energy metabolism 0.03946909776025441 0.03946909776025441 +1 GNG11,AGPAT1,GNB5,TALDO1,ADIPOR1,GNAS REAC:R-HSA-9006931 Signaling by Nuclear Receptors 0.03969372271101891 0.03969372271101891 +1 GNG11,HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,GNB5,H3F3A,RDH11,USF2,HSPB1 REAC:R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.040066533262419254 0.040066533262419254 +1 AP1B1,ARF1,AP2M1 REAC:R-HSA-3000170 Syndecan interactions 0.040066533262419254 0.040066533262419254 +1 ITGB3,ACTN1,ITGB1 REAC:R-HSA-1221632 Meiotic synapsis 0.040066533262419254 0.040066533262419254 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-9759194 Nuclear events mediated by NFE2L2 0.04080788595528625 0.04080788595528625 +1 TALDO1,SQSTM1,RBX1,G6PD,SKP1 REAC:R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.04080788595528625 0.04080788595528625 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-73854 RNA Polymerase I Promoter Clearance 0.042078299015885536 0.042078299015885536 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-8856828 Clathrin-mediated endocytosis 0.04217871619559647 0.04217871619559647 +1 CTTN,ACTB,PACSIN2,ARPC5,ACTG1,LDLRAP1,AP2M1 REAC:R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.042239387880429344 0.042239387880429344 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,TUBB4B REAC:R-HSA-73864 RNA Polymerase I Transcription 0.043144916313017166 0.043144916313017166 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.04396999591942864 0.04396999591942864 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ REAC:R-HSA-157579 Telomere Maintenance 0.04447907602140951 0.04447907602140951 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A REAC:R-HSA-445717 Aquaporin-mediated transport 0.044717180415433364 0.044717180415433364 +1 GNG11,GNB5,RAB11A,GNAS REAC:R-HSA-212165 Epigenetic regulation of gene expression 0.045370847994124414 0.045370847994124414 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A,ACTB REAC:R-HSA-9018519 Estrogen-dependent gene expression 0.046726257970719436 0.046726257970719436 +1 HIST1H2AC,HIST1H2BJ,HIST1H2BD,HIST1H2BK,H2AFJ,H3F3A,USF2 REAC:R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.046973708100848666 0.046973708100848666 +1 MPP1,GSN,ACTB,ACTG1 REAC:R-HSA-5358351 Signaling by Hedgehog 0.04784344959661201 0.04784344959661201 +1 TUBB1,TUBA1C,TUBA4A,TUBB4B,RBX1,GNAS,SKP1 REAC:R-HSA-948021 Transport to the Golgi and subsequent modification 0.04831451131663808 0.04831451131663808 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,DYNLL1,ARF1,TMED3,TUBB4B REAC:R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.04836339505451069 0.04836339505451069 +1 TUBA8,TUBB1,TUBA1C,TUBA4A,DYNLL1,TUBB4B WP:WP2272 Pathogenic Escherichia coli infection 0.0000014201459716107103 0.0000014201459716107103 +1 TUBA8,TUBB1,CTTN,TUBA1C,TUBA4A,ARPC1B,ACTB,ARPC5,ACTG1,ITGB1,TUBB4B WP:WP4313 Ferroptosis 0.0026209905501943347 0.0026209905501943347 +1 NCOA4,CHMP6,SLC40A1,SAT1,GPX4,VDAC3,FTH1,HSPB1 WP:WP306 Focal adhesion 0.0026209905501943347 0.0026209905501943347 +1 ITGA2B,ITGB3,MYL9,ILK,ACTN1,PARVB,ACTB,MYL12A,TLN1,RAP1B,ACTG1,FLNA,ITGB1,DIAPH1 WP:WP2118 Arrhythmogenic right ventricular cardiomyopathy 0.021595543998329213 0.021595543998329213 +1 ITGA2B,ITGB3,ACTN1,ACTB,LMNA,ACTG1,ITGB1 WP:WP2359 Parkin-ubiquitin proteasomal system pathway 0.021595543998329213 0.021595543998329213 +1 SEPT5,TUBA8,TUBB1,SNCA,TUBA1C,TUBA4A,TUBB4B WP:WP3888 VEGFA-VEGFR2 signaling 0.021595543998329213 0.021595543998329213 +1 ITGB3,NEXN,GPX1,TUBA1C,SH3BGRL3,PRDX6,RAB11A,TMSB4X,NAP1L1,RAP1B,SOD2,ACTG1,HMGB1,RAB37,ITGB1,GAPDH,RAB4A,TPM3,HSPB1 WP:WP2572 Primary focal segmental glomerulosclerosis (FSGS) 0.021595543998329213 0.021595543998329213 +1 ITGB3,ILK,CD151,LIMS1,TGFB1,TLN1,ITGB1 WP:WP289 Myometrial relaxation and contraction pathways 0.024669562027841697 0.024669562027841697 +1 GNG11,RGS18,RGS10,YWHAH,GNB5,ACTB,ATP2A3,ACTG1,GSTO1,GNAS WP:WP383 Striated muscle contraction pathway 0.024758640309446613 0.024758640309446613 +1 MYL9,TPM1,TPM4,ACTG1,TPM3 WP:WP5049 Glycolysis in senescence 0.02909917175465149 0.02909917175465149 +1 PKM,GAPDH,G6PD WP:WP5233 Arsenic metabolism and reactive oxygen species generation 0.02909917175465149 0.02909917175465149 +1 SOD2,GSTO1,SDHA WP:WP4290 Metabolic reprogramming in colon cancer 0.029625618120856123 0.029625618120856123 +1 TALDO1,PKM,PYCR2,GAPDH,G6PD WP:WP314 Fas ligand pathway and stress induction of heat shock proteins 0.03048175368544168 0.03048175368544168 +1 ACTB,LMNA,ACTG1,ARHGDIB,HSPB1