GO.ID	Description	p.Val	FDR	Phenotype	Genes
GO:1902806	regulation of cell cycle G1/S phase transition	8.751377395667796e-15	8.751377395667796e-15	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,FBXW7,AKT1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A,TAF1,CDKN2C,EZH2
GO:0060485	mesenchyme development	9.862282326946854e-15	9.862282326946854e-15	+1	PTEN,APC,GATA3,NOTCH1,CTNNB1,TBX3,EPHA3,SOX9,WT1,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0001837	epithelial to mesenchymal transition	8.66688266531228e-14	8.66688266531228e-14	+1	PTEN,GATA3,NOTCH1,CTNNB1,TBX3,EPHA3,SOX9,HGF,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0048762	mesenchymal cell differentiation	9.451477011574507e-14	9.451477011574507e-14	+1	PTEN,GATA3,NOTCH1,CTNNB1,TBX3,EPHA3,SOX9,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0044843	cell cycle G1/S phase transition	9.993721986968416e-14	9.993721986968416e-14	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,FBXW7,AKT1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A,TAF1,ACVR1B,CDKN2C,EZH2
GO:0010717	regulation of epithelial to mesenchymal transition	1.8256508882580954e-12	1.8256508882580954e-12	+1	PTEN,GATA3,NOTCH1,CTNNB1,EPHA3,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0046777	protein autophosphorylation	1.8925142081100463e-12	1.8925142081100463e-12	+1	EGFR,FLT3,STK11,AKT1,ATM,ERBB4,MTOR,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,FGFR3,TAF1,ATR,CDK12,ACVR1B
GO:2000045	regulation of G1/S transition of mitotic cell cycle	2.6440117754608248e-12	2.6440117754608248e-12	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A,CDKN2C
GO:0048732	gland development	3.2160315113818793e-12	3.2160315113818793e-12	+1	NF1,GATA3,FBXW7,ARHGAP35,TBX3,CEBPA,AKT1,SOX9,WT1,HGF,ERBB4,ARID5B,ELF3,FGFR2,BRCA2
GO:0000082	G1/S transition of mitotic cell cycle	2.403554115065755e-11	2.403554115065755e-11	+1	TP53,PTEN,APC,ARID1A,PBRM1,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A,ACVR1B,CDKN2C
GO:0072331	signal transduction by p53 class mediator	7.137653196303363e-11	7.137653196303363e-11	+1	TP53,CDKN2A,STK11,AKT1,ATM,CDKN1B,MTOR,ATRX,CHEK2,EP300,CDKN1A,TAF1,ATR,RPL5
GO:0045926	negative regulation of growth	7.268139245623464e-11	7.268139245623464e-11	+1	TP53,PTEN,CDKN2A,RB1,STK11,CDKN1B,WT1,BRCA1,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0007062	sister chromatid cohesion	8.555005765368791e-11	8.555005765368791e-11	+1	RB1,FBXW7,CTNNB1,CTCF,STAG2,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0014065	phosphatidylinositol 3-kinase signaling	1.0071350848598098e-10	1.0071350848598098e-10	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0030308	negative regulation of cell growth	8.083164846926474e-10	8.083164846926474e-10	+1	TP53,CDKN2A,RB1,STK11,CDKN1B,WT1,BRCA1,SMAD4,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0048015	phosphatidylinositol-mediated signaling	1.3199527239293268e-9	1.3199527239293268e-9	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0048017	inositol lipid-mediated signaling	1.5418492786859195e-9	1.5418492786859195e-9	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0051348	negative regulation of transferase activity	1.5579589423217319e-9	1.5579589423217319e-9	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,EIF4A2,MAPK8IP1,RPL5
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	5.694031390949144e-9	5.694031390949144e-9	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:1904029	regulation of cyclin-dependent protein kinase activity	8.108768308754316e-9	8.108768308754316e-9	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	1.1588105550796382e-8	1.1588105550796382e-8	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	1.2533761245729082e-8	1.2533761245729082e-8	+1	PTEN,VHL,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,RPL5,AXIN2
GO:0071478	cellular response to radiation	1.457536439510599e-8	1.457536439510599e-8	+1	TP53,GATA3,FBXW7,NPM1,STK11,ATM,BRCA1,EP300,BRCA2,CDKN1A,TAF1,ATR
GO:0003170	heart valve development	1.5194949451634015e-8	1.5194949451634015e-8	+1	APC,GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2,SMAD2,AXIN2
GO:1901796	regulation of signal transduction by p53 class mediator	1.5641857881759326e-8	1.5641857881759326e-8	+1	CDKN2A,STK11,AKT1,ATM,MTOR,CHEK2,EP300,TAF1,ATR,RPL5
GO:0071901	negative regulation of protein serine/threonine kinase activity	2.402739552077579e-8	2.402739552077579e-8	+1	PTEN,APC,NF1,CDKN2A,RB1,CEBPA,AKT1,CDKN1B,CDKN1A,MAPK8IP1
GO:0010718	positive regulation of epithelial to mesenchymal transition	2.4268338048182372e-8	2.4268338048182372e-8	+1	NOTCH1,CTNNB1,MTOR,SMAD4,TGFBR2,SMAD2,AXIN2,EZH2
GO:1902807	negative regulation of cell cycle G1/S phase transition	2.5846953541327733e-8	2.5846953541327733e-8	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
GO:0030879	mammary gland development	2.857965567450439e-8	2.857965567450439e-8	+1	GATA3,ARHGAP35,TBX3,AKT1,ERBB4,ELF3,FGFR2,BRCA2
GO:0009411	response to UV	4.631719507336726e-8	4.631719507336726e-8	+1	TP53,EGFR,FBXW7,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR
GO:0003179	heart valve morphogenesis	7.262877527359386e-8	7.262877527359386e-8	+1	GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2,SMAD2,AXIN2
GO:1904030	negative regulation of cyclin-dependent protein kinase activity	9.672064804379436e-8	9.672064804379436e-8	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B,CDKN1A
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	9.672064804379436e-8	9.672064804379436e-8	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B,CDKN1A
GO:0090398	cellular senescence	1.0318608855826374e-7	1.0318608855826374e-7	+1	TP53,PTEN,CDKN2A,NPM1,TBX3,MAP2K4,ATM,CDKN1B,CDKN1A
GO:1902893	regulation of miRNA transcription	1.1103820253010874e-7	1.1103820253010874e-7	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,FOXA1,NCOR1
GO:0003180	aortic valve morphogenesis	1.1323818823840787e-7	1.1323818823840787e-7	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2,SMAD2,AXIN2
GO:0061614	miRNA transcription	1.2603275038745428e-7	1.2603275038745428e-7	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,FOXA1,NCOR1
GO:0033673	negative regulation of kinase activity	1.6899497232115894e-7	1.6899497232115894e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,MAPK8IP1
GO:0061026	cardiac muscle tissue regeneration	1.9246850958641273e-7	1.9246850958641273e-7	+1	RUNX1,CDKN1B,ERBB4,CDKN1A
GO:0090399	replicative senescence	2.048703353054538e-7	2.048703353054538e-7	+1	TP53,CDKN2A,ATM,CHEK2,ATR
GO:0003176	aortic valve development	2.760597900663725e-7	2.760597900663725e-7	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2,SMAD2,AXIN2
GO:0035265	organ growth	3.0625310438940976e-7	3.0625310438940976e-7	+1	PTEN,NOTCH1,RUNX1,SOX9,WT1,ERBB4,FGFR2,FGFR3
GO:1903050	regulation of proteolysis involved in protein catabolic process	3.0970410912689565e-7	3.0970410912689565e-7	+1	PTEN,VHL,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,RPL5,AXIN2
GO:0018108	peptidyl-tyrosine phosphorylation	3.7322635918198946e-7	3.7322635918198946e-7	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
GO:2000628	regulation of miRNA metabolic process	3.8666472987128117e-7	3.8666472987128117e-7	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,FOXA1,NCOR1
GO:0062197	cellular response to chemical stress	3.886928302959124e-7	3.886928302959124e-7	+1	TP53,PIK3CA,EGFR,FBXW7,KEAP1,NFE2L2,AKT1,ATM,HGF,MTOR,TLR4,LRRK2,PDGFRA
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	3.956041995145586e-7	3.956041995145586e-7	+1	PTEN,VHL,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,AXIN2
GO:0018212	peptidyl-tyrosine modification	4.047317298848807e-7	4.047317298848807e-7	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
GO:0048638	regulation of developmental growth	4.554220596603119e-7	4.554220596603119e-7	+1	PTEN,NOTCH1,RUNX1,EPPK1,CDKN1B,WT1,ERBB4,FGFR2,FGFR3,CDKN1A,SIN3A
GO:1905314	semi-lunar valve development	5.117069694794165e-7	5.117069694794165e-7	+1	GATA3,RB1,NOTCH1,SOX9,TGFBR2,SMAD2,AXIN2
GO:0003007	heart morphogenesis	5.117069694794165e-7	5.117069694794165e-7	+1	APC,GATA3,NOTCH1,CTNNB1,TBX3,SOX9,FGFR2,SMAD4,TGFBR2,SOX17,SMAD2
GO:0007064	mitotic sister chromatid cohesion	5.732817710956055e-7	5.732817710956055e-7	+1	RB1,STAG2,ATRX,SMC1A,SMC3,RAD21
GO:0030330	DNA damage response, signal transduction by p53 class mediator	5.8736970711559e-7	5.8736970711559e-7	+1	TP53,CDKN2A,ATM,CDKN1B,ATRX,CHEK2,CDKN1A,ATR
GO:0006469	negative regulation of protein kinase activity	6.011755760615701e-7	6.011755760615701e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,CDKN1A,MAPK8IP1
GO:0042770	signal transduction in response to DNA damage	6.752362292133168e-7	6.752362292133168e-7	+1	TP53,CDKN2A,ATM,CDKN1B,ATRX,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:0031571	mitotic G1 DNA damage checkpoint signaling	8.682404012694097e-7	8.682404012694097e-7	+1	TP53,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
GO:0044819	mitotic G1/S transition checkpoint signaling	0.0000010592989788153254	0.0000010592989788153254	+1	TP53,ATM,CDKN1B,CHEK2,CCND1,CDKN1A
GO:1901988	negative regulation of cell cycle phase transition	0.00000109185223957048	0.00000109185223957048	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:0043550	regulation of lipid kinase activity	0.0000011546870986109305	0.0000011546870986109305	+1	PIK3R1,RB1,FLT3,ERBB4,KIT,PDGFRA,FGFR3
GO:0034087	establishment of mitotic sister chromatid cohesion	0.0000011662951543876713	0.0000011662951543876713	+1	STAG2,SMC1A,SMC3,RAD21
GO:0048608	reproductive structure development	0.0000011957551178624392	0.0000011957551178624392	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
GO:0061458	reproductive system development	0.0000011957551178624392	0.0000011957551178624392	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
GO:0009416	response to light stimulus	0.0000012367594964748617	0.0000012367594964748617	+1	TP53,EGFR,NF1,FBXW7,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR
GO:0071479	cellular response to ionizing radiation	0.0000012962219628310096	0.0000012962219628310096	+1	TP53,GATA3,ATM,BRCA1,BRCA2,CDKN1A,ATR
GO:0048511	rhythmic process	0.0000013286219789887165	0.0000013286219789887165	+1	TP53,PTEN,FBXW7,MTOR,PDGFRA,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:0010586	miRNA metabolic process	0.0000015411447411955695	0.0000015411447411955695	+1	TP53,EGFR,GATA3,AR,SOX9,WT1,FOXA1,NCOR1
GO:0043405	regulation of MAP kinase activity	0.000001572731752545429	0.000001572731752545429	+1	EGFR,NF1,FLT3,PIK3CG,TLR4,LRRK2,KIT,CDK12,MAPK8IP1,EZH2
GO:0000077	DNA damage checkpoint signaling	0.000001706893238694812	0.000001706893238694812	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:0003203	endocardial cushion morphogenesis	0.000001784906642363385	0.000001784906642363385	+1	APC,NOTCH1,TBX3,SOX9,TGFBR2,SMAD2
GO:0007063	regulation of sister chromatid cohesion	0.0000017908363994318863	0.0000017908363994318863	+1	CTNNB1,CTCF,ATRX,AXIN2,RAD21
GO:0034644	cellular response to UV	0.0000018256085065244801	0.0000018256085065244801	+1	TP53,FBXW7,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0040029	epigenetic regulation of gene expression	0.000001854696444582077	0.000001854696444582077	+1	TP53,ARID1A,RB1,DNMT3A,CTCF,ATRX,BRCA1,EP300,SIN3A,EZH2
GO:0070372	regulation of ERK1 and ERK2 cascade	0.0000020579652875493475	0.0000020579652875493475	+1	PTEN,EGFR,NOTCH1,FBXW7,BRAF,ERBB4,TLR4,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
GO:1903052	positive regulation of proteolysis involved in protein catabolic process	0.000002088603255577029	0.000002088603255577029	+1	PTEN,VHL,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,AXIN2
GO:0033002	muscle cell proliferation	0.0000022333397329847474	0.0000022333397329847474	+1	PTEN,NOTCH1,CTNNB1,RUNX1,AKT1,CDKN1B,ERBB4,FGFR2,CDKN1A
GO:0033044	regulation of chromosome organization	0.000002422541849799711	0.000002422541849799711	+1	APC,ARID1A,PBRM1,RB1,CTNNB1,CTCF,ATM,ATRX,ATR,SIN3A,AXIN2,RAD21
GO:1901991	negative regulation of mitotic cell cycle phase transition	0.000002923041452623894	0.000002923041452623894	+1	TP53,PTEN,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
GO:0031570	DNA integrity checkpoint signaling	0.0000029280230936103025	0.0000029280230936103025	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:0045930	negative regulation of mitotic cell cycle	0.000003010667060551607	0.000003010667060551607	+1	TP53,PTEN,APC,RB1,CTNNB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	0.000003075195041890586	0.000003075195041890586	+1	TP53,ATM,CDKN1B,CHEK2,CDKN1A
GO:0050821	protein stabilization	0.0000031436834270614253	0.0000031436834270614253	+1	PTEN,VHL,PIK3R1,CDKN2A,FBXW7,CHEK2,EP300,USP9X,SOX17,TAF1,RPL5
GO:0010212	response to ionizing radiation	0.0000035669019791728334	0.0000035669019791728334	+1	TP53,GATA3,STK11,ATM,BRCA1,BRCA2,CDKN1A,ATR
GO:0007623	circadian rhythm	0.0000035894486941297008	0.0000035894486941297008	+1	TP53,PTEN,FBXW7,MTOR,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:0046620	regulation of organ growth	0.000003938479332966741	0.000003938479332966741	+1	PTEN,NOTCH1,RUNX1,WT1,ERBB4,FGFR2
GO:0043551	regulation of phosphatidylinositol 3-kinase activity	0.000003938479332966741	0.000003938479332966741	+1	PIK3R1,FLT3,ERBB4,KIT,PDGFRA,FGFR3
GO:0072132	mesenchyme morphogenesis	0.0000045924781942641955	0.0000045924781942641955	+1	APC,NOTCH1,TBX3,SOX9,TGFBR2,SMAD2
GO:0003197	endocardial cushion development	0.00000531625914390978	0.00000531625914390978	+1	APC,NOTCH1,TBX3,SOX9,TGFBR2,SMAD2
GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.000005712201359372987	0.000005712201359372987	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:1902895	positive regulation of miRNA transcription	0.000006075231298088634	0.000006075231298088634	+1	TP53,EGFR,GATA3,AR,WT1,FOXA1
GO:2000677	regulation of transcription regulatory region DNA binding	0.000006075231298088634	0.000006075231298088634	+1	GATA3,RB1,EP300,TAF1,SIN3A,NSD1
GO:0000075	cell cycle checkpoint signaling	0.000006333863758734198	0.000006333863758734198	+1	TP53,APC,ATM,CDKN1B,BRCA1,CHEK2,CCND1,BRCA2,CDKN1A,ATR
GO:2000136	regulation of cell proliferation involved in heart morphogenesis	0.000009177083035964711	0.000009177083035964711	+1	NOTCH1,CTNNB1,TBX3,SMAD4
GO:0034085	establishment of sister chromatid cohesion	0.000009177083035964711	0.000009177083035964711	+1	STAG2,SMC1A,SMC3,RAD21
GO:0061180	mammary gland epithelium development	0.000009534213129582222	0.000009534213129582222	+1	GATA3,AKT1,ERBB4,FGFR2,BRCA2
GO:0001763	morphogenesis of a branching structure	0.000010435287391363431	0.000010435287391363431	+1	CTNNB1,SOX9,WT1,HGF,LRRK2,FGFR2,TGFBR2
GO:0071482	cellular response to light stimulus	0.000011397984820411147	0.000011397984820411147	+1	TP53,FBXW7,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0071902	positive regulation of protein serine/threonine kinase activity	0.000011397984820411147	0.000011397984820411147	+1	EGFR,FLT3,AKT1,PIK3CG,TLR4,LRRK2,KIT,CCND1,EZH2
GO:0097193	intrinsic apoptotic signaling pathway	0.000012102537046317214	0.000012102537046317214	+1	TP53,FBXW7,NFE2L2,STK11,AKT1,ATM,BRCA1,LRRK2,CHEK2,EP300,CDKN1A
GO:0050678	regulation of epithelial cell proliferation	0.000012510872830148107	0.000012510872830148107	+1	EGFR,NF1,GATA3,FBXW7,NRAS,AKT1,EPPK1,SOX9,FGFR2,BRCA2,EGR3
GO:0001656	metanephros development	0.000012814330548661376	0.000012814330548661376	+1	NF1,GATA3,SOX9,WT1,PDGFRA,SOX17
GO:0061323	cell proliferation involved in heart morphogenesis	0.000013051237715112908	0.000013051237715112908	+1	NOTCH1,CTNNB1,TBX3,SMAD4
GO:0001822	kidney development	0.00001396330815741772	0.00001396330815741772	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:2000630	positive regulation of miRNA metabolic process	0.000014307770339340587	0.000014307770339340587	+1	TP53,EGFR,GATA3,AR,WT1,FOXA1
GO:0044773	mitotic DNA damage checkpoint signaling	0.000014307770339340587	0.000014307770339340587	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
GO:0034089	establishment of meiotic sister chromatid cohesion	0.000015277827057543148	0.000015277827057543148	+1	SMC1A,SMC3,RAD21
GO:0070602	regulation of centromeric sister chromatid cohesion	0.000015277827057543148	0.000015277827057543148	+1	CTNNB1,CTCF,AXIN2
GO:0051091	positive regulation of DNA-binding transcription factor activity	0.000016131799892108603	0.000016131799892108603	+1	PTEN,CTNNB1,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,TAF1
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	0.000016131799892108603	0.000016131799892108603	+1	FLT3,ERBB4,KIT,PDGFRA,FGFR3
GO:0038127	ERBB signaling pathway	0.000016469524932606996	0.000016469524932606996	+1	PIK3CA,EGFR,FBXW7,AKT1,BRAF,SOX9,ERBB4,PTPN11
GO:0048863	stem cell differentiation	0.00001695431211361414	0.00001695431211361414	+1	TP53,NOTCH1,CTNNB1,SOX9,ERBB4,KIT,SETD2,PDGFRA,FGFR2
GO:1903201	regulation of oxidative stress-induced cell death	0.000017652719933482163	0.000017652719933482163	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0072001	renal system development	0.000017711122327052507	0.000017711122327052507	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	0.00001821346031552472	0.00001821346031552472	+1	TP53,EGFR,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PPP2R1A,PTPN11
GO:0001503	ossification	0.000018421811186284707	0.000018421811186284707	+1	EGFR,NF1,NOTCH1,CTNNB1,RUNX1,SOX9,HGF,FGFR2,FGFR3,PTPN11,ACVR2A
GO:0034968	histone lysine methylation	0.000019214874847974106	0.000019214874847974106	+1	CTNNB1,SETBP1,KDM6A,BRCA1,SETD2,SMAD4,EZH2
GO:0044774	mitotic DNA integrity checkpoint signaling	0.000019214874847974106	0.000019214874847974106	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
GO:0007548	sex differentiation	0.00001936159672525494	0.00001936159672525494	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,PTPN11
GO:0001666	response to hypoxia	0.000021244549389332393	0.000021244549389332393	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0060562	epithelial tube morphogenesis	0.000021244549389332393	0.000021244549389332393	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,WT1,FGFR2,TGFBR2,SOX17
GO:0050680	negative regulation of epithelial cell proliferation	0.000022182365952833062	0.000022182365952833062	+1	NF1,GATA3,FBXW7,EPPK1,SOX9,FGFR2,BRCA2
GO:0003151	outflow tract morphogenesis	0.00002351505925578518	0.00002351505925578518	+1	NOTCH1,CTNNB1,FGFR2,SMAD4,TGFBR2,SOX17
GO:0034599	cellular response to oxidative stress	0.000023574604924448717	0.000023574604924448717	+1	TP53,EGFR,FBXW7,KEAP1,NFE2L2,AKT1,HGF,TLR4,LRRK2,PDGFRA
GO:0036293	response to decreased oxygen levels	0.00002408817693935068	0.00002408817693935068	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0022612	gland morphogenesis	0.000025104685853536872	0.000025104685853536872	+1	FBXW7,SOX9,HGF,ELF3,FGFR2
GO:0060420	regulation of heart growth	0.000025104685853536872	0.000025104685853536872	+1	NOTCH1,RUNX1,WT1,ERBB4,FGFR2
GO:0045165	cell fate commitment	0.000025104685853536872	0.000025104685853536872	+1	APC,GATA3,TBX3,SOX9,WT1,FGFR2,FOXA2,SOX17,SMAD2
GO:0043276	anoikis	0.000025104685853536872	0.000025104685853536872	+1	PIK3CA,NOTCH1,STK11,AKT1,MTOR
GO:0048568	embryonic organ development	0.000026382407311278753	0.000026382407311278753	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,KIT,PDGFRA,FGFR2,TGFBR2,SOX17
GO:0035051	cardiocyte differentiation	0.00003169415759416661	0.00003169415759416661	+1	EGFR,NOTCH1,TBX3,WT1,PDGFRA,SMAD4,SOX17
GO:0043406	positive regulation of MAP kinase activity	0.000033731065500659854	0.000033731065500659854	+1	EGFR,FLT3,PIK3CG,TLR4,LRRK2,KIT,EZH2
GO:0071680	response to indole-3-methanol	0.000033731065500659854	0.000033731065500659854	+1	CTNNB1,CDH1,BRCA1
GO:0071681	cellular response to indole-3-methanol	0.000033731065500659854	0.000033731065500659854	+1	CTNNB1,CDH1,BRCA1
GO:0090218	positive regulation of lipid kinase activity	0.000033793516775128976	0.000033793516775128976	+1	FLT3,ERBB4,KIT,PDGFRA,FGFR3
GO:1900407	regulation of cellular response to oxidative stress	0.000034293526184901875	0.000034293526184901875	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0046661	male sex differentiation	0.000034293526184901875	0.000034293526184901875	+1	GATA3,TBX3,AR,SOX9,WT1,KIT
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	0.000038393246041220075	0.000038393246041220075	+1	PTEN,EGFR,FLT3,SOX9,HGF,KIT,PDGFRA
GO:0070374	positive regulation of ERK1 and ERK2 cascade	0.00004115785262376654	0.00004115785262376654	+1	EGFR,NOTCH1,FBXW7,BRAF,ERBB4,PDGFRA,FGFR2,FGFR3,PTPN11
GO:1902105	regulation of leukocyte differentiation	0.00004148788123785468	0.00004148788123785468	+1	ARID1A,PBRM1,CDKN2A,GATA3,FBXW7,RUNX1,MTOR,TLR4,TGFBR2,CBFB
GO:1902749	regulation of cell cycle G2/M phase transition	0.00004714253381630908	0.00004714253381630908	+1	TP53,CDKN2A,NPM1,ATM,BRCA1,CCND1,CDKN1A
GO:0070482	response to oxygen levels	0.0000491383303496545	0.0000491383303496545	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:1900034	regulation of cellular response to heat	0.00005120128667180684	0.00005120128667180684	+1	ATM,MTOR,EP300,ATR
GO:0044839	cell cycle G2/M phase transition	0.00005120128667180684	0.00005120128667180684	+1	TP53,CDKN2A,NPM1,ATM,BRCA1,CHEK2,CCND1,CDKN1A
GO:0045732	positive regulation of protein catabolic process	0.00005335018978565137	0.00005335018978565137	+1	APC,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,LRRK2,TAF1,AXIN2
GO:0007093	mitotic cell cycle checkpoint signaling	0.00005363666840235121	0.00005363666840235121	+1	TP53,APC,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A
GO:0071496	cellular response to external stimulus	0.00005541040857353207	0.00005541040857353207	+1	TP53,MAP3K1,ARHGAP35,MAP2K4,SOX9,MTOR,TLR4,LRRK2,FOXA2,CDKN1A
GO:0048562	embryonic organ morphogenesis	0.00005613591768458038	0.00005613591768458038	+1	NOTCH1,CTNNB1,TBX3,SOX9,PDGFRA,FGFR2,TGFBR2,SOX17
GO:0042246	tissue regeneration	0.00005750170687220449	0.00005750170687220449	+1	RUNX1,EPPK1,CDKN1B,ERBB4,CDKN1A
GO:0061138	morphogenesis of a branching epithelium	0.00005829104023102262	0.00005829104023102262	+1	CTNNB1,SOX9,WT1,HGF,FGFR2,TGFBR2
GO:1902882	regulation of response to oxidative stress	0.00005829104023102262	0.00005829104023102262	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0043409	negative regulation of MAPK cascade	0.00005872965262313623	0.00005872965262313623	+1	PTEN,NF1,TLR4,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0007173	epidermal growth factor receptor signaling pathway	0.000059905721847718314	0.000059905721847718314	+1	PIK3CA,EGFR,FBXW7,AKT1,BRAF,SOX9,PTPN11
GO:0048738	cardiac muscle tissue development	0.00006128439546533973	0.00006128439546533973	+1	NOTCH1,RUNX1,TBX3,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0003348	cardiac endothelial cell differentiation	0.00006193248069314051	0.00006193248069314051	+1	NOTCH1,SMAD4,SOX17
GO:0032927	positive regulation of activin receptor signaling pathway	0.00006193248069314051	0.00006193248069314051	+1	ACVR1B,ACVR2A,SMAD2
GO:0060956	endocardial cell differentiation	0.00006193248069314051	0.00006193248069314051	+1	NOTCH1,SMAD4,SOX17
GO:0018022	peptidyl-lysine methylation	0.00006305282455045522	0.00006305282455045522	+1	CTNNB1,SETBP1,KDM6A,BRCA1,SETD2,SMAD4,EZH2
GO:0060419	heart growth	0.00007230603735123663	0.00007230603735123663	+1	NOTCH1,RUNX1,WT1,ERBB4,FGFR2
GO:0036473	cell death in response to oxidative stress	0.0000798900301961889	0.0000798900301961889	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:1901800	positive regulation of proteasomal protein catabolic process	0.00008036064896963017	0.00008036064896963017	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,AXIN2
GO:0009612	response to mechanical stimulus	0.00008036064896963017	0.00008036064896963017	+1	PIK3CA,CTNNB1,MAP3K1,MAP2K4,SOX9,TLR4,KIT
GO:0003281	ventricular septum development	0.00008096109977772823	0.00008096109977772823	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0014706	striated muscle tissue development	0.00008096109977772823	0.00008096109977772823	+1	NOTCH1,RUNX1,TBX3,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0016571	histone methylation	0.0000849188217829713	0.0000849188217829713	+1	CTNNB1,SETBP1,KDM6A,BRCA1,SETD2,SMAD4,EZH2
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	0.00008900507560853498	0.00008900507560853498	+1	TP53,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PTPN11
GO:0050870	positive regulation of T cell activation	0.00009096585603529538	0.00009096585603529538	+1	PIK3CA,ARID1A,PBRM1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0030217	T cell differentiation	0.00009818517785914932	0.00009818517785914932	+1	ARID1A,PBRM1,PIK3R1,CDKN2A,GATA3,RUNX1,KIT,TGFBR2,CBFB
GO:0009880	embryonic pattern specification	0.00010125723188344423	0.00010125723188344423	+1	TBX3,WT1,ERBB4,FGFR2,SMAD2
GO:0010507	negative regulation of autophagy	0.00010789583369741154	0.00010789583369741154	+1	PIK3CA,VHL,AKT1,HGF,MTOR,LRRK2
GO:0007389	pattern specification process	0.00010991615212708862	0.00010991615212708862	+1	APC,NOTCH1,TBX3,WT1,ERBB4,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0003181	atrioventricular valve morphogenesis	0.00011363223759713412	0.00011363223759713412	+1	NOTCH1,SMAD4,TGFBR2,AXIN2
GO:0060421	positive regulation of heart growth	0.00011363223759713412	0.00011363223759713412	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0046622	positive regulation of organ growth	0.00011363223759713412	0.00011363223759713412	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0034502	protein localization to chromosome	0.0001256803980560175	0.0001256803980560175	+1	RB1,CTCF,ATRX,SETD2,BRCA2,ATR,RAD21
GO:0002573	myeloid leukocyte differentiation	0.0001325197562141097	0.0001325197562141097	+1	GATA3,FBXW7,RUNX1,CEBPA,MTOR,TLR4,KIT,TGFBR2
GO:0060043	regulation of cardiac muscle cell proliferation	0.00013585532262483954	0.00013585532262483954	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0010632	regulation of epithelial cell migration	0.00013590211773694425	0.00013590211773694425	+1	PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,PIK3CG,SOX9,MTOR
GO:0003157	endocardium development	0.00015801126945372613	0.00015801126945372613	+1	NOTCH1,SMAD4,SOX17
GO:0060828	regulation of canonical Wnt signaling pathway	0.00016362167786669322	0.00016362167786669322	+1	APC,EGFR,STK11,SOX9,LRRK2,FGFR2,SOX17,TBL1XR1,AXIN2
GO:0062014	negative regulation of small molecule metabolic process	0.0001650245149994341	0.0001650245149994341	+1	TP53,AKT1,SOX9,BRCA1,EP300,NCOR1
GO:1903320	regulation of protein modification by small protein conjugation or removal	0.00016897755462118077	0.00016897755462118077	+1	PTEN,CDKN2A,FBXW7,CTNNB1,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0045445	myoblast differentiation	0.00017612291000653691	0.00017612291000653691	+1	ARID1A,PBRM1,RB1,NOTCH1,TBX3,SOX9
GO:0048145	regulation of fibroblast proliferation	0.0001863965797840322	0.0001863965797840322	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:1903039	positive regulation of leukocyte cell-cell adhesion	0.0001863965797840322	0.0001863965797840322	+1	PIK3CA,ARID1A,PBRM1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0003171	atrioventricular valve development	0.00018935908938316485	0.00018935908938316485	+1	NOTCH1,SMAD4,TGFBR2,AXIN2
GO:0000819	sister chromatid segregation	0.00019985937977326986	0.00019985937977326986	+1	APC,ARID1A,PBRM1,RB1,STAG2,ATM,CHEK2,SMC1A,SMC3
GO:0010518	positive regulation of phospholipase activity	0.0002047081203799518	0.0002047081203799518	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0048144	fibroblast proliferation	0.0002047081203799518	0.0002047081203799518	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:0071824	protein-DNA complex subunit organization	0.0002056724294145981	0.0002056724294145981	+1	TP53,ARID1A,RB1,NPM1,SOX9,ATRX,SETD2,TAF1,HIST1H2BD
GO:0031929	TOR signaling	0.00020940202772338668	0.00020940202772338668	+1	PIK3CA,GATA3,STK11,AKT1,ATM,MTOR,USP9X
GO:0007622	rhythmic behavior	0.0002193935716070108	0.0002193935716070108	+1	TP53,PTEN,MTOR,NCOR1
GO:0048512	circadian behavior	0.0002193935716070108	0.0002193935716070108	+1	TP53,PTEN,MTOR,NCOR1
GO:0060537	muscle tissue development	0.0002193935716070108	0.0002193935716070108	+1	NF1,NOTCH1,RUNX1,TBX3,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0060038	cardiac muscle cell proliferation	0.0002193935716070108	0.0002193935716070108	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0010721	negative regulation of cell development	0.00022307958686487226	0.00022307958686487226	+1	PTEN,NF1,CDKN2A,NOTCH1,FBXW7,RUNX1,TLR4,CBFB
GO:0045475	locomotor rhythm	0.00022352457113983007	0.00022352457113983007	+1	PTEN,MTOR,NCOR1
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0002238593385410458	0.0002238593385410458	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,AXIN2
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	0.00022699820844078943	0.00022699820844078943	+1	KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,AXIN2
GO:0045834	positive regulation of lipid metabolic process	0.00022699820844078943	0.00022699820844078943	+1	FLT3,AKT1,ERBB4,MTOR,KIT,PDGFRA,FGFR3
GO:0045582	positive regulation of T cell differentiation	0.00023729586558031386	0.00023729586558031386	+1	ARID1A,PBRM1,GATA3,RUNX1,TGFBR2,CBFB
GO:0061136	regulation of proteasomal protein catabolic process	0.00023845134164452865	0.00023845134164452865	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,AXIN2
GO:0055021	regulation of cardiac muscle tissue growth	0.00024961626070231724	0.00024961626070231724	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0060688	regulation of morphogenesis of a branching structure	0.00024961626070231724	0.00024961626070231724	+1	SOX9,HGF,LRRK2,FGFR2
GO:0016242	negative regulation of macroautophagy	0.00024961626070231724	0.00024961626070231724	+1	PIK3CA,AKT1,MTOR,LRRK2
GO:0008406	gonad development	0.0002504979187285683	0.0002504979187285683	+1	GATA3,AR,SOX9,WT1,KIT,PDGFRA
GO:0003208	cardiac ventricle morphogenesis	0.00025893590672815107	0.00025893590672815107	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0008584	male gonad development	0.00025893590672815107	0.00025893590672815107	+1	GATA3,AR,SOX9,WT1,KIT
GO:0051568	histone H3-K4 methylation	0.00025893590672815107	0.00025893590672815107	+1	CTNNB1,SETBP1,KDM6A,BRCA1,SMAD4
GO:0031396	regulation of protein ubiquitination	0.0002646699812938145	0.0002646699812938145	+1	PTEN,CDKN2A,FBXW7,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0045580	regulation of T cell differentiation	0.0002706183371151988	0.0002706183371151988	+1	ARID1A,PBRM1,CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:0045137	development of primary sexual characteristics	0.00028112172230206084	0.00028112172230206084	+1	GATA3,AR,SOX9,WT1,KIT,PDGFRA
GO:0046546	development of primary male sexual characteristics	0.00028113250526222346	0.00028113250526222346	+1	GATA3,AR,SOX9,WT1,KIT
GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.00028403260275452043	0.00028403260275452043	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,SIN3A,ACVR1B,ACVR2A,SMAD2
GO:0045922	negative regulation of fatty acid metabolic process	0.0002844589791301111	0.0002844589791301111	+1	AKT1,SOX9,BRCA1,NCOR1
GO:0051101	regulation of DNA binding	0.00029503760728091517	0.00029503760728091517	+1	GATA3,RB1,EP300,TAF1,SIN3A,NSD1
GO:0048705	skeletal system morphogenesis	0.00029503760728091517	0.00029503760728091517	+1	CTNNB1,SOX9,PDGFRA,FGFR2,FGFR3,TGFBR2
GO:0002053	positive regulation of mesenchymal cell proliferation	0.00029814250263464424	0.00029814250263464424	+1	SOX9,FGFR2,TGFBR2
GO:0070601	centromeric sister chromatid cohesion	0.00029814250263464424	0.00029814250263464424	+1	CTNNB1,CTCF,AXIN2
GO:0051494	negative regulation of cytoskeleton organization	0.0003371139692434871	0.0003371139692434871	+1	PIK3CA,APC,NAV3,PIK3R1,NPM1,BRCA1,SMAD4
GO:0060412	ventricular septum morphogenesis	0.00036789389140937074	0.00036789389140937074	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0048872	homeostasis of number of cells	0.0003807692907814447	0.0003807692907814447	+1	NOTCH1,FLT3,AKT1,SOX9,KIT,ACVR1B,ACVR2A
GO:1901989	positive regulation of cell cycle phase transition	0.00039164180061201914	0.00039164180061201914	+1	EGFR,RB1,NPM1,AKT1,CCND1,EZH2
GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	0.00039633761762411767	0.00039633761762411767	+1	EP300,TAF1,NSD1
GO:0072497	mesenchymal stem cell differentiation	0.00039633761762411767	0.00039633761762411767	+1	CTNNB1,SOX9,PDGFRA
GO:0071456	cellular response to hypoxia	0.0004122708545657859	0.0004122708545657859	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR
GO:0045661	regulation of myoblast differentiation	0.0004133695918853973	0.0004133695918853973	+1	ARID1A,PBRM1,NOTCH1,TBX3,SOX9
GO:0010517	regulation of phospholipase activity	0.0004467201340993999	0.0004467201340993999	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0006479	protein methylation	0.0004687992150124466	0.0004687992150124466	+1	CTNNB1,SETBP1,KDM6A,BRCA1,SETD2,SMAD4,EZH2
GO:0008213	protein alkylation	0.0004687992150124466	0.0004687992150124466	+1	CTNNB1,SETBP1,KDM6A,BRCA1,SETD2,SMAD4,EZH2
GO:0060193	positive regulation of lipase activity	0.00047955048425266865	0.00047955048425266865	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0048754	branching morphogenesis of an epithelial tube	0.00047955048425266865	0.00047955048425266865	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
GO:0019827	stem cell population maintenance	0.0004799071585734377	0.0004799071585734377	+1	ARID1A,NOTCH1,CTNNB1,SOX9,KIT,SIN3A
GO:0036294	cellular response to decreased oxygen levels	0.0004799071585734377	0.0004799071585734377	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR
GO:0018107	peptidyl-threonine phosphorylation	0.0004799071585734377	0.0004799071585734377	+1	STK11,AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
GO:0045621	positive regulation of lymphocyte differentiation	0.0004799071585734377	0.0004799071585734377	+1	ARID1A,PBRM1,GATA3,RUNX1,TGFBR2,CBFB
GO:0007259	receptor signaling pathway via JAK-STAT	0.0004836998951834341	0.0004836998951834341	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0003205	cardiac chamber development	0.0005035776282448006	0.0005035776282448006	+1	GATA3,NOTCH1,TBX3,FGFR2,SMAD4,TGFBR2
GO:0051177	meiotic sister chromatid cohesion	0.0005035776282448006	0.0005035776282448006	+1	SMC1A,SMC3,RAD21
GO:0036302	atrioventricular canal development	0.0005035776282448006	0.0005035776282448006	+1	TBX3,SMAD4,PTPN11
GO:0051547	regulation of keratinocyte migration	0.0005035776282448006	0.0005035776282448006	+1	PTEN,EPPK1,MTOR
GO:0098727	maintenance of cell number	0.0005035776282448006	0.0005035776282448006	+1	ARID1A,NOTCH1,CTNNB1,SOX9,KIT,SIN3A
GO:0031099	regeneration	0.000508044486901625	0.000508044486901625	+1	RUNX1,EPPK1,CDKN1B,ERBB4,CDKN1A
GO:0010828	positive regulation of glucose transmembrane transport	0.0005166737818164003	0.0005166737818164003	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0055017	cardiac muscle tissue growth	0.0005166737818164003	0.0005166737818164003	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0003279	cardiac septum development	0.0005448713710681839	0.0005448713710681839	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0007405	neuroblast proliferation	0.0005779172377934764	0.0005779172377934764	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:0014855	striated muscle cell proliferation	0.0005779172377934764	0.0005779172377934764	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0010719	negative regulation of epithelial to mesenchymal transition	0.0005779172377934764	0.0005779172377934764	+1	PTEN,GATA3,FOXA1,FOXA2
GO:0097696	receptor signaling pathway via STAT	0.0006081456947491993	0.0006081456947491993	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0030518	intracellular steroid hormone receptor signaling pathway	0.0006121353571469491	0.0006121353571469491	+1	ARID1A,AR,BRCA1,FOXA1,EP300,NCOR1
GO:0001708	cell fate specification	0.0006252984534462428	0.0006252984534462428	+1	APC,TBX3,SOX9,FOXA2,SOX17
GO:0034614	cellular response to reactive oxygen species	0.0006419873250892401	0.0006419873250892401	+1	EGFR,NFE2L2,AKT1,HGF,LRRK2,PDGFRA
GO:0071560	cellular response to transforming growth factor beta stimulus	0.0006678400723072147	0.0006678400723072147	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,SIN3A,SMAD2
GO:0042752	regulation of circadian rhythm	0.0006751122346871091	0.0006751122346871091	+1	TP53,FBXW7,MTOR,USP9X,SIN3A,EZH2
GO:0045619	regulation of lymphocyte differentiation	0.0006812434073248518	0.0006812434073248518	+1	ARID1A,PBRM1,CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:0042509	regulation of tyrosine phosphorylation of STAT protein	0.0007159310807652271	0.0007159310807652271	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:1903202	negative regulation of oxidative stress-induced cell death	0.0007159310807652271	0.0007159310807652271	+1	NFE2L2,AKT1,HGF,LRRK2
GO:0043627	response to estrogen	0.0007159310807652271	0.0007159310807652271	+1	GATA3,AR,BRCA1,EP300
GO:0043401	steroid hormone mediated signaling pathway	0.0007405211917760721	0.0007405211917760721	+1	ARID1A,AR,BRCA1,FOXA1,EP300,NCOR1
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	0.0007586070936416886	0.0007586070936416886	+1	FLT3,SOX9,HGF,KIT,PDGFRA
GO:0018210	peptidyl-threonine modification	0.0007724935627044961	0.0007724935627044961	+1	STK11,AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
GO:0003214	cardiac left ventricle morphogenesis	0.0007737203050095513	0.0007737203050095513	+1	NOTCH1,SMAD4,TGFBR2
GO:0045662	negative regulation of myoblast differentiation	0.0007737203050095513	0.0007737203050095513	+1	NOTCH1,TBX3,SOX9
GO:0048701	embryonic cranial skeleton morphogenesis	0.0007737203050095513	0.0007737203050095513	+1	PDGFRA,FGFR2,TGFBR2
GO:0070141	response to UV-A	0.0007737203050095513	0.0007737203050095513	+1	EGFR,AKT1,CCND1
GO:0071559	response to transforming growth factor beta	0.0007915670779998244	0.0007915670779998244	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,SIN3A,SMAD2
GO:0001649	osteoblast differentiation	0.0008095762357493264	0.0008095762357493264	+1	NF1,NOTCH1,CTNNB1,SOX9,HGF,FGFR2,ACVR2A
GO:0006282	regulation of DNA repair	0.0008157563727710663	0.0008157563727710663	+1	ARID1A,PBRM1,EGFR,BRCA1,POLQ,SETD2,ATR,AXIN2
GO:0071241	cellular response to inorganic substance	0.0008399606805797122	0.0008399606805797122	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,ATRX,LRRK2
GO:0071453	cellular response to oxygen levels	0.0008421187398973498	0.0008421187398973498	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR
GO:0048704	embryonic skeletal system morphogenesis	0.0008637412627274399	0.0008637412627274399	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:2000278	regulation of DNA biosynthetic process	0.0008794826310229962	0.0008794826310229962	+1	TP53,CTNNB1,ATM,HGF,CDKN1A,ATR
GO:0060348	bone development	0.0008794826310229962	0.0008794826310229962	+1	TP53,FBXW7,SOX9,KIT,FGFR2,FGFR3
GO:0072073	kidney epithelium development	0.0009027261401919677	0.0009027261401919677	+1	GATA3,CTNNB1,SOX9,WT1,FGFR2
GO:0007260	tyrosine phosphorylation of STAT protein	0.0009027261401919677	0.0009027261401919677	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:2001252	positive regulation of chromosome organization	0.0009163032747873275	0.0009163032747873275	+1	CTNNB1,ATM,ATRX,ATR,SIN3A,RAD21
GO:0097695	establishment of protein-containing complex localization to telomere	0.0009175759436999062	0.0009175759436999062	+1	ATM,ATR
GO:0003249	cell proliferation involved in heart valve morphogenesis	0.0009175759436999062	0.0009175759436999062	+1	NOTCH1,SMAD4
GO:0003250	regulation of cell proliferation involved in heart valve morphogenesis	0.0009175759436999062	0.0009175759436999062	+1	NOTCH1,SMAD4
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	0.0009175759436999062	0.0009175759436999062	+1	GATA3,BRCA2
GO:0097694	establishment of RNA localization to telomere	0.0009175759436999062	0.0009175759436999062	+1	ATM,ATR
GO:0010464	regulation of mesenchymal cell proliferation	0.0009297925815588563	0.0009297925815588563	+1	SOX9,FGFR2,TGFBR2
GO:0060045	positive regulation of cardiac muscle cell proliferation	0.0009297925815588563	0.0009297925815588563	+1	NOTCH1,ERBB4,FGFR2
GO:0032924	activin receptor signaling pathway	0.0009337355023360905	0.0009337355023360905	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
GO:0006739	NADP metabolic process	0.0009337355023360905	0.0009337355023360905	+1	TP53,IDH1,MTOR,IDH2
GO:0009408	response to heat	0.0009494378640613978	0.0009494378640613978	+1	AKT1,ATM,MTOR,EP300,ATR
GO:0090068	positive regulation of cell cycle process	0.0009573516504496236	0.0009573516504496236	+1	EGFR,RB1,NPM1,AKT1,ATRX,CCND1,RAD21,EZH2
GO:0034728	nucleosome organization	0.001041231199977318	0.001041231199977318	+1	ARID1A,NPM1,SOX9,ATRX,SETD2,HIST1H2BD
GO:0051546	keratinocyte migration	0.0011178858319346458	0.0011178858319346458	+1	PTEN,EPPK1,MTOR
GO:1901032	negative regulation of response to reactive oxygen species	0.0011178858319346458	0.0011178858319346458	+1	NFE2L2,HGF,LRRK2
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	0.0011178858319346458	0.0011178858319346458	+1	EGFR,AKT1,CCND1
GO:1903206	negative regulation of hydrogen peroxide-induced cell death	0.0011178858319346458	0.0011178858319346458	+1	NFE2L2,HGF,LRRK2
GO:0048485	sympathetic nervous system development	0.0011178858319346458	0.0011178858319346458	+1	NF1,GATA3,CTNNB1
GO:0003231	cardiac ventricle development	0.0011322921276152545	0.0011322921276152545	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0070828	heterochromatin organization	0.0011322921276152545	0.0011322921276152545	+1	RB1,ATRX,SIN3A,MECOM,EZH2
GO:0045927	positive regulation of growth	0.0011322921276152545	0.0011322921276152545	+1	EGFR,NOTCH1,AKT1,WT1,ERBB4,MTOR,FGFR2
GO:1902106	negative regulation of leukocyte differentiation	0.0011322921276152545	0.0011322921276152545	+1	CDKN2A,FBXW7,RUNX1,TLR4,CBFB
GO:1903707	negative regulation of hemopoiesis	0.0012008673615195348	0.0012008673615195348	+1	CDKN2A,FBXW7,RUNX1,TLR4,CBFB
GO:0001657	ureteric bud development	0.0012262709508319618	0.0012262709508319618	+1	GATA3,SOX9,WT1,FGFR2
GO:0031330	negative regulation of cellular catabolic process	0.0012508480506347435	0.0012508480506347435	+1	PIK3CA,VHL,AKT1,HGF,MTOR,LRRK2,AXIN2
GO:0003002	regionalization	0.0012726809128076255	0.0012726809128076255	+1	NOTCH1,TBX3,WT1,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0045945	positive regulation of transcription by RNA polymerase III	0.0013206331131921268	0.0013206331131921268	+1	AR,MTOR,SF3B1
GO:0051571	positive regulation of histone H3-K4 methylation	0.0013206331131921268	0.0013206331131921268	+1	CTNNB1,BRCA1,SMAD4
GO:0071480	cellular response to gamma radiation	0.0013206331131921268	0.0013206331131921268	+1	TP53,ATM,ATR
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	0.0013206331131921268	0.0013206331131921268	+1	CDKN2A,ATM,ATR
GO:1902692	regulation of neuroblast proliferation	0.0013206331131921268	0.0013206331131921268	+1	NF1,CTNNB1,LRRK2
GO:0007626	locomotory behavior	0.0013224003528220704	0.0013224003528220704	+1	PTEN,MTOR,FOXA2,NCOR1
GO:0001947	heart looping	0.0013224003528220704	0.0013224003528220704	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:0072163	mesonephric epithelium development	0.0013224003528220704	0.0013224003528220704	+1	GATA3,SOX9,WT1,FGFR2
GO:0030521	androgen receptor signaling pathway	0.0013224003528220704	0.0013224003528220704	+1	ARID1A,AR,EP300,NCOR1
GO:2001234	negative regulation of apoptotic signaling pathway	0.0013224003528220704	0.0013224003528220704	+1	RB1,NFE2L2,AKT1,AR,HGF,BRCA1,LRRK2
GO:0072164	mesonephric tubule development	0.0013224003528220704	0.0013224003528220704	+1	GATA3,SOX9,WT1,FGFR2
GO:0061448	connective tissue development	0.0013738263112670214	0.0013738263112670214	+1	RUNX1,SOX9,WT1,ARID5B,FGFR3,PTPN11
GO:0000086	G2/M transition of mitotic cell cycle	0.0013738263112670214	0.0013738263112670214	+1	CDKN2A,ATM,BRCA1,CHEK2,CCND1,CDKN1A
GO:0006289	nucleotide-excision repair	0.001402247529663343	0.001402247529663343	+1	TP53,ARID1A,PBRM1,BRCA2,ERCC2
GO:0046660	female sex differentiation	0.0014332999149219274	0.0014332999149219274	+1	TBX3,WT1,KIT,PDGFRA
GO:0060191	regulation of lipase activity	0.0014778010297519229	0.0014778010297519229	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0044344	cellular response to fibroblast growth factor stimulus	0.0014778010297519229	0.0014778010297519229	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:0000302	response to reactive oxygen species	0.0014841928876412423	0.0014841928876412423	+1	EGFR,NFE2L2,AKT1,HGF,LRRK2,PDGFRA
GO:0007179	transforming growth factor beta receptor signaling pathway	0.0014949619028477026	0.0014949619028477026	+1	STK11,EP300,SMAD4,USP9X,TGFBR2,SIN3A,SMAD2
GO:0062009	secondary palate development	0.0015272277985662569	0.0015272277985662569	+1	SMAD4,TGFBR2,SMAD2
GO:0055023	positive regulation of cardiac muscle tissue growth	0.0015272277985662569	0.0015272277985662569	+1	NOTCH1,ERBB4,FGFR2
GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	0.0015272277985662569	0.0015272277985662569	+1	PTEN,CDKN1B,CDKN1A
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	0.0015435247080014343	0.0015435247080014343	+1	CDKN2A,USP9X,TAF1,RPL5
GO:0048709	oligodendrocyte differentiation	0.0015435247080014343	0.0015435247080014343	+1	PTEN,NF1,NOTCH1,SOX9
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	0.0015474120298769973	0.0015474120298769973	+1	TP53,ATM,BRCA1,CHEK2,EP300
GO:0071774	response to fibroblast growth factor	0.00162830300904362	0.00162830300904362	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:0060972	left/right pattern formation	0.00162830300904362	0.00162830300904362	+1	NOTCH1,TBX3,TGFBR2,SOX17,SMAD2
GO:0007368	determination of left/right symmetry	0.00162830300904362	0.00162830300904362	+1	NOTCH1,TBX3,TGFBR2,SOX17,SMAD2
GO:1903321	negative regulation of protein modification by small protein conjugation or removal	0.00162830300904362	0.00162830300904362	+1	CDKN2A,CTNNB1,AKT1,TAF1,RPL5
GO:0003206	cardiac chamber morphogenesis	0.00162830300904362	0.00162830300904362	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0000070	mitotic sister chromatid segregation	0.0016286553720242644	0.0016286553720242644	+1	APC,RB1,STAG2,ATM,CHEK2,SMC1A,SMC3
GO:0043470	regulation of carbohydrate catabolic process	0.0016340711117565953	0.0016340711117565953	+1	TP53,MTOR,EP300,NCOR1
GO:0030916	otic vesicle formation	0.0016340711117565953	0.0016340711117565953	+1	SOX9,FGFR2
GO:0048853	forebrain morphogenesis	0.0016340711117565953	0.0016340711117565953	+1	PTEN,NF1
GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis	0.0016340711117565953	0.0016340711117565953	+1	NOTCH1,TBX3
GO:0010452	histone H3-K36 methylation	0.0016340711117565953	0.0016340711117565953	+1	SETBP1,SETD2
GO:0071600	otic vesicle morphogenesis	0.0016340711117565953	0.0016340711117565953	+1	SOX9,FGFR2
GO:0097676	histone H3-K36 dimethylation	0.0016340711117565953	0.0016340711117565953	+1	SETBP1,SETD2
GO:0030520	intracellular estrogen receptor signaling pathway	0.0016340711117565953	0.0016340711117565953	+1	ARID1A,AR,BRCA1,FOXA1
GO:0060445	branching involved in salivary gland morphogenesis	0.0016340711117565953	0.0016340711117565953	+1	HGF,FGFR2
GO:0048873	homeostasis of number of cells within a tissue	0.0016340711117565953	0.0016340711117565953	+1	NOTCH1,SOX9
GO:0030522	intracellular receptor signaling pathway	0.0016340711117565953	0.0016340711117565953	+1	ARID1A,AR,BRCA1,FOXA1,EP300,ASXL1,NCOR1,EZH2
GO:2000793	cell proliferation involved in heart valve development	0.0016340711117565953	0.0016340711117565953	+1	NOTCH1,SMAD4
GO:0060740	prostate gland epithelium morphogenesis	0.0016340711117565953	0.0016340711117565953	+1	SOX9,FGFR2
GO:0002011	morphogenesis of an epithelial sheet	0.0016340711117565953	0.0016340711117565953	+1	PTEN,NOTCH1,ARHGAP35,MTOR
GO:0060736	prostate gland growth	0.0016340711117565953	0.0016340711117565953	+1	SOX9,FGFR2
GO:2000047	regulation of cell-cell adhesion mediated by cadherin	0.0017233747264126795	0.0017233747264126795	+1	NOTCH1,FOXA1,FOXA2
GO:1902883	negative regulation of response to oxidative stress	0.0017233747264126795	0.0017233747264126795	+1	NFE2L2,HGF,LRRK2
GO:1904666	regulation of ubiquitin protein ligase activity	0.0017233747264126795	0.0017233747264126795	+1	PTEN,CDKN2A,RPL5
GO:1904031	positive regulation of cyclin-dependent protein kinase activity	0.0017233747264126795	0.0017233747264126795	+1	EGFR,AKT1,CCND1
GO:2001185	regulation of CD8-positive, alpha-beta T cell activation	0.0017233747264126795	0.0017233747264126795	+1	RUNX1,CBFB,MAPK8IP1
GO:1903205	regulation of hydrogen peroxide-induced cell death	0.0017233747264126795	0.0017233747264126795	+1	NFE2L2,HGF,LRRK2
GO:0043009	chordate embryonic development	0.001744841909696159	0.001744841909696159	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:0001823	mesonephros development	0.0017459099321647084	0.0017459099321647084	+1	GATA3,SOX9,WT1,FGFR2
GO:0001570	vasculogenesis	0.0017459099321647084	0.0017459099321647084	+1	NOTCH1,WT1,TGFBR2,SOX17
GO:0001889	liver development	0.0017459099321647084	0.0017459099321647084	+1	NF1,FBXW7,CEBPA,ARID5B
GO:0003143	embryonic heart tube morphogenesis	0.0017459099321647084	0.0017459099321647084	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:0010389	regulation of G2/M transition of mitotic cell cycle	0.0017459099321647084	0.0017459099321647084	+1	CDKN2A,ATM,BRCA1,CCND1,CDKN1A
GO:0061371	determination of heart left/right asymmetry	0.0017459099321647084	0.0017459099321647084	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:0045833	negative regulation of lipid metabolic process	0.0017459099321647084	0.0017459099321647084	+1	FBXW7,AKT1,SOX9,BRCA1,NCOR1
GO:0062012	regulation of small molecule metabolic process	0.001836443425672937	0.001836443425672937	+1	TP53,AKT1,SOX9,MTOR,BRCA1,EP300,FOXA2,NCOR1
GO:0008286	insulin receptor signaling pathway	0.0018384077568972205	0.0018384077568972205	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0051099	positive regulation of binding	0.0018612951252770708	0.0018612951252770708	+1	GATA3,RB1,LRRK2,EP300,USP9X,TAF1
GO:0071772	response to BMP	0.0018612951252770708	0.0018612951252770708	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0071773	cellular response to BMP stimulus	0.0018612951252770708	0.0018612951252770708	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0006109	regulation of carbohydrate metabolic process	0.0018612951252770708	0.0018612951252770708	+1	TP53,AKT1,MTOR,EP300,FOXA2,NCOR1
GO:0031297	replication fork processing	0.0018654059696795752	0.0018654059696795752	+1	ATRX,BRCA1,BRCA2,ATR
GO:1903053	regulation of extracellular matrix organization	0.0018654059696795752	0.0018654059696795752	+1	RB1,NOTCH1,RUNX1,AXIN2
GO:0120163	negative regulation of cold-induced thermogenesis	0.0018654059696795752	0.0018654059696795752	+1	RB1,NOTCH1,STK11,TLR4
GO:0061008	hepaticobiliary system development	0.0018654059696795752	0.0018654059696795752	+1	NF1,FBXW7,CEBPA,ARID5B
GO:0032925	regulation of activin receptor signaling pathway	0.001955882434123047	0.001955882434123047	+1	ACVR1B,ACVR2A,SMAD2
GO:0010463	mesenchymal cell proliferation	0.001955882434123047	0.001955882434123047	+1	SOX9,FGFR2,TGFBR2
GO:0048806	genitalia development	0.001955882434123047	0.001955882434123047	+1	TBX3,WT1,PTPN11
GO:0030336	negative regulation of cell migration	0.001996927517600081	0.001996927517600081	+1	PTEN,NAV3,NF1,NOTCH1,CDH1,AKT1,EPPK1,SIN3A
GO:0060411	cardiac septum morphogenesis	0.001996927517600081	0.001996927517600081	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0071260	cellular response to mechanical stimulus	0.001996927517600081	0.001996927517600081	+1	MAP3K1,MAP2K4,SOX9,TLR4
GO:0060993	kidney morphogenesis	0.001996927517600081	0.001996927517600081	+1	GATA3,SOX9,WT1,LRRK2
GO:0030071	regulation of mitotic metaphase/anaphase transition	0.001996927517600081	0.001996927517600081	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:0046425	regulation of receptor signaling pathway via JAK-STAT	0.001996927517600081	0.001996927517600081	+1	VHL,NOTCH1,ERBB4,KIT,PPP2R1A
GO:0045667	regulation of osteoblast differentiation	0.001996927517600081	0.001996927517600081	+1	NOTCH1,SOX9,HGF,FGFR2,ACVR2A
GO:1902808	positive regulation of cell cycle G1/S phase transition	0.001996927517600081	0.001996927517600081	+1	EGFR,AKT1,CCND1,EZH2
GO:1902107	positive regulation of leukocyte differentiation	0.0020538012234151606	0.0020538012234151606	+1	ARID1A,PBRM1,GATA3,RUNX1,TGFBR2,CBFB
GO:1903708	positive regulation of hemopoiesis	0.0020538012234151606	0.0020538012234151606	+1	ARID1A,PBRM1,GATA3,RUNX1,TGFBR2,CBFB
GO:0048660	regulation of smooth muscle cell proliferation	0.002098401305351134	0.002098401305351134	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:0072080	nephron tubule development	0.002134977448438086	0.002134977448438086	+1	GATA3,CTNNB1,SOX9,WT1
GO:0010827	regulation of glucose transmembrane transport	0.002134977448438086	0.002134977448438086	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0055006	cardiac cell development	0.002134977448438086	0.002134977448438086	+1	NOTCH1,TBX3,PDGFRA,SMAD4
GO:0034605	cellular response to heat	0.002134977448438086	0.002134977448438086	+1	ATM,MTOR,EP300,ATR
GO:0051438	regulation of ubiquitin-protein transferase activity	0.002134977448438086	0.002134977448438086	+1	PTEN,CDKN2A,FBXW7,RPL5
GO:0009855	determination of bilateral symmetry	0.002186611037505812	0.002186611037505812	+1	NOTCH1,TBX3,TGFBR2,SOX17,SMAD2
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	0.002186611037505812	0.002186611037505812	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:1903076	regulation of protein localization to plasma membrane	0.002186611037505812	0.002186611037505812	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0097305	response to alcohol	0.002186611037505812	0.002186611037505812	+1	CTNNB1,CDH1,BRCA1,TGFBR2,SMAD2
GO:0010821	regulation of mitochondrion organization	0.002192667395945116	0.002192667395945116	+1	TP53,FBXW7,AKT1,HGF,LRRK2,EP300
GO:0051569	regulation of histone H3-K4 methylation	0.0022060908871970315	0.0022060908871970315	+1	CTNNB1,BRCA1,SMAD4
GO:0007610	behavior	0.0022388289861445423	0.0022388289861445423	+1	TP53,PTEN,EGFR,NF1,MTOR,LRRK2,FOXA2,NCOR1
GO:0060560	developmental growth involved in morphogenesis	0.0022689075389941186	0.0022689075389941186	+1	NOTCH1,CTNNB1,SOX9,FGFR2,USP9X,SIN3A
GO:0061326	renal tubule development	0.002271541037130114	0.002271541037130114	+1	GATA3,CTNNB1,SOX9,WT1
GO:1901216	positive regulation of neuron death	0.002271541037130114	0.002271541037130114	+1	NF1,FBXW7,CTNNB1,TLR4
GO:0048706	embryonic skeletal system development	0.002271541037130114	0.002271541037130114	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	0.002271541037130114	0.002271541037130114	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:0009799	specification of symmetry	0.002271541037130114	0.002271541037130114	+1	NOTCH1,TBX3,TGFBR2,SOX17,SMAD2
GO:0048659	smooth muscle cell proliferation	0.002271541037130114	0.002271541037130114	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:0072006	nephron development	0.0023884105460957174	0.0023884105460957174	+1	GATA3,CTNNB1,SOX9,WT1,PDGFRA
GO:0071383	cellular response to steroid hormone stimulus	0.0024271830861259066	0.0024271830861259066	+1	ARID1A,AR,BRCA1,FOXA1,EP300,NCOR1
GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	0.002450247232213998	0.002450247232213998	+1	RUNX1,CBFB
GO:2000679	positive regulation of transcription regulatory region DNA binding	0.002450247232213998	0.002450247232213998	+1	GATA3,RB1,EP300
GO:0030539	male genitalia development	0.002450247232213998	0.002450247232213998	+1	TBX3,WT1
GO:1901723	negative regulation of cell proliferation involved in kidney development	0.002450247232213998	0.002450247232213998	+1	GATA3,WT1
GO:0048546	digestive tract morphogenesis	0.002450247232213998	0.002450247232213998	+1	PDGFRA,FGFR2,SOX17
GO:2000435	negative regulation of protein neddylation	0.002450247232213998	0.002450247232213998	+1	CDKN2A,RPL5
GO:2000617	positive regulation of histone H3-K9 acetylation	0.002450247232213998	0.002450247232213998	+1	BRCA1,SMAD4
GO:0065004	protein-DNA complex assembly	0.002450247232213998	0.002450247232213998	+1	TP53,RB1,NPM1,SOX9,ATRX,TAF1,HIST1H2BD
GO:0006102	isocitrate metabolic process	0.002450247232213998	0.002450247232213998	+1	IDH1,IDH2
GO:0060729	intestinal epithelial structure maintenance	0.002450247232213998	0.002450247232213998	+1	SOX9,TLR4
GO:0060512	prostate gland morphogenesis	0.002450247232213998	0.002450247232213998	+1	SOX9,FGFR2
GO:0003160	endocardium morphogenesis	0.002450247232213998	0.002450247232213998	+1	NOTCH1,SOX17
GO:0071285	cellular response to lithium ion	0.002450247232213998	0.002450247232213998	+1	CDH1,CDKN1B
GO:1903223	positive regulation of oxidative stress-induced neuron death	0.002450247232213998	0.002450247232213998	+1	FBXW7,TLR4
GO:0035066	positive regulation of histone acetylation	0.002450247232213998	0.002450247232213998	+1	BRCA1,SMAD4,SF3B1
GO:0003149	membranous septum morphogenesis	0.002450247232213998	0.002450247232213998	+1	FGFR2,TGFBR2
GO:0044784	metaphase/anaphase transition of cell cycle	0.0024510248562436957	0.0024510248562436957	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:0043542	endothelial cell migration	0.002481605986257627	0.002481605986257627	+1	PIK3CA,NF1,GATA3,NOTCH1,AKT1,PIK3CG,EGR3
GO:0071248	cellular response to metal ion	0.0025488806723894014	0.0025488806723894014	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:0009792	embryo development ending in birth or egg hatching	0.0025494513196377606	0.0025494513196377606	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:0035050	embryonic heart tube development	0.0025494513196377606	0.0025494513196377606	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:1904892	regulation of receptor signaling pathway via STAT	0.002558211369836691	0.002558211369836691	+1	VHL,NOTCH1,ERBB4,KIT,PPP2R1A
GO:0007254	JNK cascade	0.0026305546209430914	0.0026305546209430914	+1	EGFR,MAP2K4,LRRK2,MAPK8IP1,MECOM,NCOR1
GO:0008637	apoptotic mitochondrial changes	0.0026750665897024924	0.0026750665897024924	+1	TP53,CDKN2A,AKT1,HGF,ERBB4
GO:2000379	positive regulation of reactive oxygen species metabolic process	0.002717931130623656	0.002717931130623656	+1	TP53,TLR4,TGFBR2,CDKN1A
GO:0036474	cell death in response to hydrogen peroxide	0.002745501373617304	0.002745501373617304	+1	NFE2L2,HGF,LRRK2
GO:0072210	metanephric nephron development	0.002745501373617304	0.002745501373617304	+1	SOX9,WT1,PDGFRA
GO:1901031	regulation of response to reactive oxygen species	0.002745501373617304	0.002745501373617304	+1	NFE2L2,HGF,LRRK2
GO:0036037	CD8-positive, alpha-beta T cell activation	0.002745501373617304	0.002745501373617304	+1	RUNX1,CBFB,MAPK8IP1
GO:0006304	DNA modification	0.0027855333087076386	0.0027855333087076386	+1	DNMT3A,WT1,TET2,ATRX,USP9X
GO:0050679	positive regulation of epithelial cell proliferation	0.0027995358625458526	0.0027995358625458526	+1	EGFR,NRAS,AKT1,SOX9,FGFR2,EGR3
GO:1903078	positive regulation of protein localization to plasma membrane	0.0028910812157062907	0.0028910812157062907	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:0045005	DNA-templated DNA replication maintenance of fidelity	0.0028910812157062907	0.0028910812157062907	+1	ATRX,BRCA1,BRCA2,ATR
GO:0045931	positive regulation of mitotic cell cycle	0.003051832496451553	0.003051832496451553	+1	EGFR,RB1,AKT1,FOXA1,CCND1
GO:0009798	axis specification	0.0030803637363420798	0.0030803637363420798	+1	TBX3,WT1,FOXA2,SMAD2
GO:0003272	endocardial cushion formation	0.0030803637363420798	0.0030803637363420798	+1	NOTCH1,TBX3,TGFBR2
GO:0010332	response to gamma radiation	0.0030803637363420798	0.0030803637363420798	+1	TP53,ATM,ATR
GO:0060317	cardiac epithelial to mesenchymal transition	0.0030803637363420798	0.0030803637363420798	+1	NOTCH1,TBX3,TGFBR2
GO:0003148	outflow tract septum morphogenesis	0.0030803637363420798	0.0030803637363420798	+1	FGFR2,SMAD4,TGFBR2
GO:0022408	negative regulation of cell-cell adhesion	0.003198283556776063	0.003198283556776063	+1	CDKN2A,NOTCH1,CDH1,RUNX1,AKT1,CBFB
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	0.0032812148174747096	0.0032812148174747096	+1	FLT3,ERBB4,KIT,FGFR3
GO:0035270	endocrine system development	0.0032812148174747096	0.0032812148174747096	+1	NF1,AKT1,WT1,FOXA2
GO:0003158	endothelium development	0.0033123945060104945	0.0033123945060104945	+1	NOTCH1,CTNNB1,SMAD4,SOX17,VEZF1
GO:2000020	positive regulation of male gonad development	0.00341612647953664	0.00341612647953664	+1	SOX9,WT1
GO:1902498	regulation of protein autoubiquitination	0.00341612647953664	0.00341612647953664	+1	LRRK2,TAF1
GO:0090394	negative regulation of excitatory postsynaptic potential	0.00341612647953664	0.00341612647953664	+1	PTEN,LRRK2
GO:0033045	regulation of sister chromatid segregation	0.00341612647953664	0.00341612647953664	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:0035924	cellular response to vascular endothelial growth factor stimulus	0.00341612647953664	0.00341612647953664	+1	PIK3CA,NOTCH1,PDGFRA,EGR3
GO:0002062	chondrocyte differentiation	0.00341612647953664	0.00341612647953664	+1	RUNX1,SOX9,FGFR3,PTPN11
GO:2000615	regulation of histone H3-K9 acetylation	0.00341612647953664	0.00341612647953664	+1	BRCA1,SMAD4
GO:0090183	regulation of kidney development	0.00341612647953664	0.00341612647953664	+1	GATA3,SOX9,WT1
GO:0048755	branching morphogenesis of a nerve	0.00341612647953664	0.00341612647953664	+1	LRRK2,FGFR2
GO:0043456	regulation of pentose-phosphate shunt	0.00341612647953664	0.00341612647953664	+1	TP53,MTOR
GO:0010226	response to lithium ion	0.00341612647953664	0.00341612647953664	+1	CDH1,CDKN1B
GO:0031509	subtelomeric heterochromatin formation	0.00341612647953664	0.00341612647953664	+1	ATRX,EZH2
GO:1900180	regulation of protein localization to nucleus	0.00341612647953664	0.00341612647953664	+1	PIK3R1,CDKN2A,CDH1,AKT1,SIN3A
GO:1905323	telomerase holoenzyme complex assembly	0.00341612647953664	0.00341612647953664	+1	ATM,ATR
GO:0043970	histone H3-K9 acetylation	0.00341612647953664	0.00341612647953664	+1	BRCA1,SMAD4
GO:0030513	positive regulation of BMP signaling pathway	0.00341612647953664	0.00341612647953664	+1	NOTCH1,SMAD4,SMAD2
GO:0043525	positive regulation of neuron apoptotic process	0.00341612647953664	0.00341612647953664	+1	NF1,FBXW7,CTNNB1
GO:1905941	positive regulation of gonad development	0.00341612647953664	0.00341612647953664	+1	SOX9,WT1
GO:0071599	otic vesicle development	0.00341612647953664	0.00341612647953664	+1	SOX9,FGFR2
GO:1904888	cranial skeletal system development	0.00341612647953664	0.00341612647953664	+1	PDGFRA,FGFR2,TGFBR2
GO:0009266	response to temperature stimulus	0.0035341195439271347	0.0035341195439271347	+1	AKT1,ATM,MTOR,EP300,ATR
GO:0009755	hormone-mediated signaling pathway	0.0035663561172616523	0.0035663561172616523	+1	ARID1A,AR,BRCA1,FOXA1,EP300,NCOR1
GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus	0.0037546416670135394	0.0037546416670135394	+1	STK11,EP300,SMAD4
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.0037546416670135394	0.0037546416670135394	+1	FBXW7,NFE2L2,AKT1
GO:0046326	positive regulation of glucose import	0.0037546416670135394	0.0037546416670135394	+1	PIK3R1,AKT1,PTPN11
GO:0044331	cell-cell adhesion mediated by cadherin	0.0037546416670135394	0.0037546416670135394	+1	NOTCH1,FOXA1,FOXA2
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	0.0037546416670135394	0.0037546416670135394	+1	STK11,EP300,SMAD4
GO:0045815	transcription initiation-coupled chromatin remodeling	0.0037546416670135394	0.0037546416670135394	+1	TP53,ARID1A,EP300
GO:0045861	negative regulation of proteolysis	0.0037888591208420654	0.0037888591208420654	+1	CDKN2A,AKT1,HGF,LRRK2,USP9X,TAF1,RPL5
GO:0048565	digestive tract development	0.0038350338906269943	0.0038350338906269943	+1	KIT,PDGFRA,FGFR2,SOX17
GO:1903051	negative regulation of proteolysis involved in protein catabolic process	0.0038350338906269943	0.0038350338906269943	+1	CDKN2A,USP9X,TAF1,RPL5
GO:0030900	forebrain development	0.003897541916351448	0.003897541916351448	+1	PTEN,NF1,ERBB4,LRRK2,FGFR2,SIN3A
GO:1904377	positive regulation of protein localization to cell periphery	0.004072347255879301	0.004072347255879301	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:0048640	negative regulation of developmental growth	0.004072347255879301	0.004072347255879301	+1	PTEN,CDKN1B,FGFR3,CDKN1A
GO:1904375	regulation of protein localization to cell periphery	0.004142817721404779	0.004142817721404779	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0045637	regulation of myeloid cell differentiation	0.004148948159411293	0.004148948159411293	+1	FBXW7,RUNX1,MTOR,TLR4,ACVR1B,ACVR2A
GO:0048645	animal organ formation	0.004154384918189855	0.004154384918189855	+1	WT1,FGFR2,SOX17
GO:2000758	positive regulation of peptidyl-lysine acetylation	0.004154384918189855	0.004154384918189855	+1	BRCA1,SMAD4,SF3B1
GO:2000377	regulation of reactive oxygen species metabolic process	0.004290256345207337	0.004290256345207337	+1	TP53,TLR4,BRCA1,TGFBR2,CDKN1A
GO:0055123	digestive system development	0.004290256345207337	0.004290256345207337	+1	KIT,PDGFRA,FGFR2,SOX17
GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	0.004290256345207337	0.004290256345207337	+1	BRCA1,FOXA1,EP300,NCOR1
GO:0008543	fibroblast growth factor receptor signaling pathway	0.004290256345207337	0.004290256345207337	+1	GATA3,FGFR2,FGFR3,PTPN11
GO:0043491	protein kinase B signaling	0.004387468899347727	0.004387468899347727	+1	PIK3CA,PTEN,EGFR,GATA3,AKT1,PIK3CG
GO:0071897	DNA biosynthetic process	0.004387468899347727	0.004387468899347727	+1	TP53,CTNNB1,ATM,HGF,CDKN1A,ATR
GO:0035148	tube formation	0.004540405899554915	0.004540405899554915	+1	GATA3,NOTCH1,SOX9,FGFR2
GO:1901798	positive regulation of signal transduction by p53 class mediator	0.00454936415957644	0.00454936415957644	+1	CDKN2A,ATM,ATR
GO:2000018	regulation of male gonad development	0.00454936415957644	0.00454936415957644	+1	SOX9,WT1
GO:0048715	negative regulation of oligodendrocyte differentiation	0.00454936415957644	0.00454936415957644	+1	NF1,NOTCH1
GO:0060602	branch elongation of an epithelium	0.00454936415957644	0.00454936415957644	+1	SOX9,FGFR2
GO:0008340	determination of adult lifespan	0.00454936415957644	0.00454936415957644	+1	TP53,LRRK2
GO:0006359	regulation of transcription by RNA polymerase III	0.00454936415957644	0.00454936415957644	+1	AR,MTOR,SF3B1
GO:0071481	cellular response to X-ray	0.00454936415957644	0.00454936415957644	+1	GATA3,ATM
GO:0007435	salivary gland morphogenesis	0.00454936415957644	0.00454936415957644	+1	HGF,FGFR2
GO:0071364	cellular response to epidermal growth factor stimulus	0.00454936415957644	0.00454936415957644	+1	EGFR,SOX9,PTPN11
GO:0071371	cellular response to gonadotropin stimulus	0.00454936415957644	0.00454936415957644	+1	NOTCH1,WT1
GO:0003190	atrioventricular valve formation	0.00454936415957644	0.00454936415957644	+1	NOTCH1,SMAD4
GO:0048545	response to steroid hormone	0.004755423689578419	0.004755423689578419	+1	ARID1A,AR,BRCA1,FOXA1,EP300,NCOR1
GO:0002244	hematopoietic progenitor cell differentiation	0.004755423689578419	0.004755423689578419	+1	TP53,NOTCH1,FLT3,KIT
GO:0061041	regulation of wound healing	0.004767716714161708	0.004767716714161708	+1	PTEN,EPPK1,MTOR,PDGFRA,FOXA2
GO:0072009	nephron epithelium development	0.005024631659626406	0.005024631659626406	+1	GATA3,CTNNB1,SOX9,WT1
GO:0010001	glial cell differentiation	0.0051584005289252305	0.0051584005289252305	+1	PTEN,NF1,NOTCH1,SOX9,PRX
GO:0055007	cardiac muscle cell differentiation	0.005301265994634324	0.005301265994634324	+1	TBX3,WT1,PDGFRA,SMAD4
GO:0031507	heterochromatin formation	0.005301265994634324	0.005301265994634324	+1	RB1,ATRX,SIN3A,EZH2
GO:0032526	response to retinoic acid	0.005301265994634324	0.005301265994634324	+1	EPHA3,SOX9,ATM,ASXL1
GO:0051225	spindle assembly	0.005347509662781938	0.005347509662781938	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:0000578	embryonic axis specification	0.005484305823849224	0.005484305823849224	+1	TBX3,WT1,SMAD2
GO:0006275	regulation of DNA replication	0.0055534006427088245	0.0055534006427088245	+1	EGFR,ATRX,PPP2R1A,ATR,SMC3
GO:0097191	extrinsic apoptotic signaling pathway	0.005664290643324465	0.005664290643324465	+1	PTEN,AKT1,AR,BRCA1,FGFR3,ACVR1B
GO:0006260	DNA replication	0.005664290643324465	0.005664290643324465	+1	EGFR,ATRX,BRCA1,BRCA2,PPP2R1A,ATR,SMC3
GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	0.005837423037518443	0.005837423037518443	+1	NOTCH1,TGFBR2
GO:0034698	response to gonadotropin	0.005837423037518443	0.005837423037518443	+1	NOTCH1,WT1
GO:2000573	positive regulation of DNA biosynthetic process	0.005837423037518443	0.005837423037518443	+1	CTNNB1,ATM,HGF,ATR
GO:0060644	mammary gland epithelial cell differentiation	0.005837423037518443	0.005837423037518443	+1	AKT1,ERBB4
GO:1905939	regulation of gonad development	0.005837423037518443	0.005837423037518443	+1	SOX9,WT1
GO:0032071	regulation of endodeoxyribonuclease activity	0.005837423037518443	0.005837423037518443	+1	NPM1,AKT1
GO:0002327	immature B cell differentiation	0.005837423037518443	0.005837423037518443	+1	ATM,KIT
GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation	0.005837423037518443	0.005837423037518443	+1	RUNX1,CBFB
GO:2000739	regulation of mesenchymal stem cell differentiation	0.005837423037518443	0.005837423037518443	+1	SOX9,PDGFRA
GO:1902031	regulation of NADP metabolic process	0.005837423037518443	0.005837423037518443	+1	TP53,MTOR
GO:1903689	regulation of wound healing, spreading of epidermal cells	0.005837423037518443	0.005837423037518443	+1	PTEN,MTOR
GO:0090400	stress-induced premature senescence	0.005837423037518443	0.005837423037518443	+1	TP53,CDKN1A
GO:0007431	salivary gland development	0.005837423037518443	0.005837423037518443	+1	HGF,FGFR2
GO:0072239	metanephric glomerulus vasculature development	0.005837423037518443	0.005837423037518443	+1	WT1,PDGFRA
GO:0033599	regulation of mammary gland epithelial cell proliferation	0.005837423037518443	0.005837423037518443	+1	GATA3,BRCA2
GO:0010839	negative regulation of keratinocyte proliferation	0.005837423037518443	0.005837423037518443	+1	EPPK1,FGFR2
GO:0070198	protein localization to chromosome, telomeric region	0.005873557587735186	0.005873557587735186	+1	ATRX,BRCA2,ATR
GO:0060675	ureteric bud morphogenesis	0.005873557587735186	0.005873557587735186	+1	GATA3,SOX9,WT1
GO:0070849	response to epidermal growth factor	0.005873557587735186	0.005873557587735186	+1	EGFR,SOX9,PTPN11
GO:0071542	dopaminergic neuron differentiation	0.005873557587735186	0.005873557587735186	+1	CTNNB1,FOXA1,FOXA2
GO:0048483	autonomic nervous system development	0.005873557587735186	0.005873557587735186	+1	NF1,GATA3,CTNNB1
GO:0007095	mitotic G2 DNA damage checkpoint signaling	0.005873557587735186	0.005873557587735186	+1	ATM,BRCA1,CDKN1A
GO:0031214	biomineral tissue development	0.006059723694861281	0.006059723694861281	+1	NOTCH1,SOX9,FGFR2,FGFR3,ACVR2A
GO:0090307	mitotic spindle assembly	0.006059723694861281	0.006059723694861281	+1	STAG2,CHEK2,SMC1A,SMC3
GO:0051236	establishment of RNA localization	0.006059723694861281	0.006059723694861281	+1	NPM1,ATM,SETD2,TGFBR2,ATR
GO:0007162	negative regulation of cell adhesion	0.006223093536862006	0.006223093536862006	+1	PTEN,CDKN2A,NOTCH1,CDH1,RUNX1,AKT1,CBFB
GO:0043583	ear development	0.006343540562348506	0.006343540562348506	+1	GATA3,SOX9,FGFR2,PTPN11
GO:0072593	reactive oxygen species metabolic process	0.006343540562348506	0.006343540562348506	+1	TP53,TLR4,BRCA1,LRRK2,TGFBR2,CDKN1A
GO:0019362	pyridine nucleotide metabolic process	0.006343540562348506	0.006343540562348506	+1	TP53,IDH1,MTOR,IDH2
GO:0019217	regulation of fatty acid metabolic process	0.006343540562348506	0.006343540562348506	+1	AKT1,SOX9,BRCA1,NCOR1
GO:1900182	positive regulation of protein localization to nucleus	0.006343540562348506	0.006343540562348506	+1	PIK3R1,CDKN2A,CDH1,AKT1
GO:0046496	nicotinamide nucleotide metabolic process	0.006343540562348506	0.006343540562348506	+1	TP53,IDH1,MTOR,IDH2
GO:0032206	positive regulation of telomere maintenance	0.006343540562348506	0.006343540562348506	+1	CTNNB1,ATM,ATRX,ATR
GO:0070741	response to interleukin-6	0.006346267762636707	0.006346267762636707	+1	CEBPA,SMAD4,FOXA2
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	0.006346267762636707	0.006346267762636707	+1	TP53,VHL,NFE2L2
GO:0031062	positive regulation of histone methylation	0.006346267762636707	0.006346267762636707	+1	CTNNB1,BRCA1,SMAD4
GO:0090090	negative regulation of canonical Wnt signaling pathway	0.006452549904001351	0.006452549904001351	+1	APC,STK11,SOX9,SOX17,AXIN2
GO:0070661	leukocyte proliferation	0.006610936782547781	0.006610936782547781	+1	CDKN2A,FLT3,PIK3CG,ATM,KIT,TGFBR2,MAPK8IP1
GO:0033135	regulation of peptidyl-serine phosphorylation	0.006685789018722607	0.006685789018722607	+1	PTEN,EGFR,AKT1,BRAF,NSD1
GO:0031334	positive regulation of protein-containing complex assembly	0.006875347345853916	0.006875347345853916	+1	TP53,NAV3,AJUBA,ATM,TLR4,ATR
GO:0032212	positive regulation of telomere maintenance via telomerase	0.006879705463967186	0.006879705463967186	+1	CTNNB1,ATM,ATR
GO:0055010	ventricular cardiac muscle tissue morphogenesis	0.006879705463967186	0.006879705463967186	+1	NOTCH1,FGFR2,SMAD4
GO:0072171	mesonephric tubule morphogenesis	0.006879705463967186	0.006879705463967186	+1	GATA3,SOX9,WT1
GO:0090505	epiboly involved in wound healing	0.006879705463967186	0.006879705463967186	+1	PTEN,ARHGAP35,MTOR
GO:0044319	wound healing, spreading of cells	0.006879705463967186	0.006879705463967186	+1	PTEN,ARHGAP35,MTOR
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	0.00688915055824877	0.00688915055824877	+1	PTEN,CDKN2A,FBXW7,BRCA1,LRRK2
GO:0061351	neural precursor cell proliferation	0.006942176150464418	0.006942176150464418	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:0031397	negative regulation of protein ubiquitination	0.006942176150464418	0.006942176150464418	+1	CDKN2A,AKT1,TAF1,RPL5
GO:0060443	mammary gland morphogenesis	0.007098597931238416	0.007098597931238416	+1	ELF3,FGFR2
GO:0003416	endochondral bone growth	0.007098597931238416	0.007098597931238416	+1	SOX9,FGFR3
GO:0048557	embryonic digestive tract morphogenesis	0.007098597931238416	0.007098597931238416	+1	PDGFRA,FGFR2
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.007098597931238416	0.007098597931238416	+1	STK11,EP300,SMAD4,SIN3A,SMAD2
GO:0072079	nephron tubule formation	0.007098597931238416	0.007098597931238416	+1	GATA3,SOX9
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.007098597931238416	0.007098597931238416	+1	VHL,NFE2L2
GO:1901722	regulation of cell proliferation involved in kidney development	0.007098597931238416	0.007098597931238416	+1	GATA3,WT1
GO:0002328	pro-B cell differentiation	0.007098597931238416	0.007098597931238416	+1	NOTCH1,FLT3
GO:1901653	cellular response to peptide	0.007098597931238416	0.007098597931238416	+1	TP53,PIK3CA,APC,PIK3R1,AKT1,TLR4,PTPN11
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	0.007098597931238416	0.007098597931238416	+1	FOXA1,FOXA2
GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	0.007098597931238416	0.007098597931238416	+1	RUNX1,CBFB
GO:0062042	regulation of cardiac epithelial to mesenchymal transition	0.007098597931238416	0.007098597931238416	+1	NOTCH1,TGFBR2
GO:0090520	sphingolipid mediated signaling pathway	0.007098597931238416	0.007098597931238416	+1	AKT1,PIK3CG
GO:0003376	sphingosine-1-phosphate receptor signaling pathway	0.007098597931238416	0.007098597931238416	+1	AKT1,PIK3CG
GO:0046322	negative regulation of fatty acid oxidation	0.007098597931238416	0.007098597931238416	+1	AKT1,SOX9
GO:2000027	regulation of animal organ morphogenesis	0.007169563572968001	0.007169563572968001	+1	GATA3,SOX9,WT1,HGF
GO:1901992	positive regulation of mitotic cell cycle phase transition	0.007169563572968001	0.007169563572968001	+1	EGFR,RB1,AKT1,CCND1
GO:0046631	alpha-beta T cell activation	0.0072487551813894555	0.0072487551813894555	+1	GATA3,RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	0.007309451107491297	0.007309451107491297	+1	EGFR,AKT1,CCND1
GO:0035850	epithelial cell differentiation involved in kidney development	0.007309451107491297	0.007309451107491297	+1	GATA3,CTNNB1,WT1
GO:0090504	epiboly	0.007309451107491297	0.007309451107491297	+1	PTEN,ARHGAP35,MTOR
GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	0.007477793274428968	0.007477793274428968	+1	STK11,EP300,SMAD4,SIN3A,SMAD2
GO:0051100	negative regulation of binding	0.007477793274428968	0.007477793274428968	+1	AKT1,LRRK2,CDKN1A,TAF1,SIN3A
GO:0045814	negative regulation of gene expression, epigenetic	0.007851065744877943	0.007851065744877943	+1	RB1,ATRX,SIN3A,EZH2
GO:0072524	pyridine-containing compound metabolic process	0.007851065744877943	0.007851065744877943	+1	TP53,IDH1,MTOR,IDH2
GO:0021953	central nervous system neuron differentiation	0.007851065744877943	0.007851065744877943	+1	PTEN,ARHGAP35,FGFR2,SIN3A
GO:0045581	negative regulation of T cell differentiation	0.007865739828930504	0.007865739828930504	+1	CDKN2A,RUNX1,CBFB
GO:0046329	negative regulation of JNK cascade	0.007865739828930504	0.007865739828930504	+1	MAPK8IP1,MECOM,NCOR1
GO:0032355	response to estradiol	0.007865739828930504	0.007865739828930504	+1	EGFR,CTNNB1,FOXA1
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	0.007865739828930504	0.007865739828930504	+1	CDKN2A,ATM,ATR
GO:0046638	positive regulation of alpha-beta T cell differentiation	0.007865739828930504	0.007865739828930504	+1	RUNX1,TGFBR2,CBFB
GO:0051053	negative regulation of DNA metabolic process	0.007926524154931742	0.007926524154931742	+1	TP53,ATM,POLQ,CDKN1A,ATR
GO:0030509	BMP signaling pathway	0.007926524154931742	0.007926524154931742	+1	NOTCH1,SMAD4,USP9X,ACVR2A,SMAD2
GO:0051983	regulation of chromosome segregation	0.007926524154931742	0.007926524154931742	+1	APC,ARID1A,PBRM1,RB1,ATM
GO:0042692	muscle cell differentiation	0.008142260711440951	0.008142260711440951	+1	NOTCH1,TBX3,WT1,KIT,PDGFRA,FGFR2,SMAD4
GO:1903034	regulation of response to wounding	0.008193618334350372	0.008193618334350372	+1	PTEN,EPPK1,MTOR,PDGFRA,FOXA2
GO:0031668	cellular response to extracellular stimulus	0.008407659174243482	0.008407659174243482	+1	TP53,ARHGAP35,MTOR,LRRK2,FOXA2,CDKN1A
GO:1901214	regulation of neuron death	0.008407659174243482	0.008407659174243482	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
GO:0035520	monoubiquitinated protein deubiquitination	0.008426803141406747	0.008426803141406747	+1	BAP1,USP9X,ASXL1
GO:0009948	anterior/posterior axis specification	0.008426803141406747	0.008426803141406747	+1	TBX3,WT1,FOXA2
GO:0060021	roof of mouth development	0.008426803141406747	0.008426803141406747	+1	SMAD4,TGFBR2,SMAD2
GO:1904358	positive regulation of telomere maintenance via telomere lengthening	0.008426803141406747	0.008426803141406747	+1	CTNNB1,ATM,ATR
GO:1904667	negative regulation of ubiquitin protein ligase activity	0.008429553933820371	0.008429553933820371	+1	CDKN2A,RPL5
GO:0060039	pericardium development	0.008429553933820371	0.008429553933820371	+1	NOTCH1,WT1
GO:0046822	regulation of nucleocytoplasmic transport	0.008429553933820371	0.008429553933820371	+1	PIK3R1,CDKN2A,CDH1,SETD2
GO:0032070	regulation of deoxyribonuclease activity	0.008429553933820371	0.008429553933820371	+1	NPM1,AKT1
GO:0030850	prostate gland development	0.008429553933820371	0.008429553933820371	+1	SOX9,FGFR2
GO:0007183	SMAD protein complex assembly	0.008429553933820371	0.008429553933820371	+1	SMAD4,SMAD2
GO:0033598	mammary gland epithelial cell proliferation	0.008429553933820371	0.008429553933820371	+1	GATA3,BRCA2
GO:0051865	protein autoubiquitination	0.008429553933820371	0.008429553933820371	+1	BRCA1,LRRK2,BRCA2,TAF1
GO:0043217	myelin maintenance	0.008429553933820371	0.008429553933820371	+1	PTEN,PRX
GO:0003401	axis elongation	0.008429553933820371	0.008429553933820371	+1	SOX9,FGFR2
GO:0003183	mitral valve morphogenesis	0.008429553933820371	0.008429553933820371	+1	NOTCH1,AXIN2
GO:0072182	regulation of nephron tubule epithelial cell differentiation	0.008429553933820371	0.008429553933820371	+1	GATA3,CTNNB1
GO:1904659	glucose transmembrane transport	0.008429553933820371	0.008429553933820371	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	0.008429553933820371	0.008429553933820371	+1	AKT1,TLR4
GO:0140719	constitutive heterochromatin formation	0.008429553933820371	0.008429553933820371	+1	ATRX,EZH2
GO:1905208	negative regulation of cardiocyte differentiation	0.008429553933820371	0.008429553933820371	+1	EGFR,SMAD4
GO:0033157	regulation of intracellular protein transport	0.00846368060967278	0.00846368060967278	+1	PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,LRRK2
GO:0090287	regulation of cellular response to growth factor stimulus	0.008495251130950641	0.008495251130950641	+1	GATA3,NOTCH1,STK11,EP300,SMAD4,SIN3A,SMAD2
GO:0016573	histone acetylation	0.008560862690701611	0.008560862690701611	+1	BRCA1,EP300,SMAD4,BRCA2,SF3B1
GO:0046632	alpha-beta T cell differentiation	0.008740753694144206	0.008740753694144206	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0051145	smooth muscle cell differentiation	0.008877956436351206	0.008877956436351206	+1	NOTCH1,KIT,FGFR2
GO:0008585	female gonad development	0.008877956436351206	0.008877956436351206	+1	WT1,KIT,PDGFRA
GO:0010863	positive regulation of phospholipase C activity	0.008877956436351206	0.008877956436351206	+1	EGFR,KIT,PDGFRA
GO:1901985	positive regulation of protein acetylation	0.008877956436351206	0.008877956436351206	+1	BRCA1,SMAD4,SF3B1
GO:0046324	regulation of glucose import	0.008877956436351206	0.008877956436351206	+1	PIK3R1,AKT1,PTPN11
GO:0072078	nephron tubule morphogenesis	0.008877956436351206	0.008877956436351206	+1	GATA3,SOX9,WT1
GO:2000779	regulation of double-strand break repair	0.009375970245666514	0.009375970245666514	+1	ARID1A,PBRM1,POLQ,SETD2,ATR
GO:0018393	internal peptidyl-lysine acetylation	0.009375970245666514	0.009375970245666514	+1	BRCA1,EP300,SMAD4,BRCA2,SF3B1
GO:0030278	regulation of ossification	0.009497344053022341	0.009497344053022341	+1	NOTCH1,SOX9,PTPN11,ACVR2A
GO:0031295	T cell costimulation	0.009497642686686384	0.009497642686686384	+1	PIK3CA,AKT1,PTPN11
GO:0061005	cell differentiation involved in kidney development	0.009497642686686384	0.009497642686686384	+1	GATA3,CTNNB1,WT1
GO:0048662	negative regulation of smooth muscle cell proliferation	0.009497642686686384	0.009497642686686384	+1	PTEN,CDKN1B,CDKN1A
GO:0046545	development of primary female sexual characteristics	0.009497642686686384	0.009497642686686384	+1	WT1,KIT,PDGFRA
GO:0043620	regulation of DNA-templated transcription in response to stress	0.009497642686686384	0.009497642686686384	+1	TP53,VHL,NFE2L2
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	0.009497642686686384	0.009497642686686384	+1	FBXW7,NFE2L2,AKT1
GO:2001242	regulation of intrinsic apoptotic signaling pathway	0.00960098644712579	0.00960098644712579	+1	TP53,FBXW7,NFE2L2,AKT1,LRRK2
GO:0008645	hexose transmembrane transport	0.009857584474342146	0.009857584474342146	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0006475	internal protein amino acid acetylation	0.009903589939942344	0.009903589939942344	+1	BRCA1,EP300,SMAD4,BRCA2,SF3B1
GO:0046606	negative regulation of centrosome cycle	0.009927438973852901	0.009927438973852901	+1	NPM1,BRCA1
GO:0010826	negative regulation of centrosome duplication	0.009927438973852901	0.009927438973852901	+1	NPM1,BRCA1
GO:0098868	bone growth	0.009927438973852901	0.009927438973852901	+1	SOX9,FGFR3
GO:0043374	CD8-positive, alpha-beta T cell differentiation	0.009927438973852901	0.009927438973852901	+1	RUNX1,CBFB
GO:0003174	mitral valve development	0.009927438973852901	0.009927438973852901	+1	NOTCH1,AXIN2
GO:0030325	adrenal gland development	0.009927438973852901	0.009927438973852901	+1	NF1,WT1
GO:0060911	cardiac cell fate commitment	0.009927438973852901	0.009927438973852901	+1	WT1,SOX17
GO:0035988	chondrocyte proliferation	0.009927438973852901	0.009927438973852901	+1	SOX9,FGFR3
GO:2000177	regulation of neural precursor cell proliferation	0.010026257800160079	0.010026257800160079	+1	NF1,CTNNB1,LRRK2
GO:0045912	negative regulation of carbohydrate metabolic process	0.010026257800160079	0.010026257800160079	+1	EP300,FOXA2,NCOR1
GO:1902116	negative regulation of organelle assembly	0.010026257800160079	0.010026257800160079	+1	BRCA1,LRRK2,SMAD4
GO:0072028	nephron morphogenesis	0.010026257800160079	0.010026257800160079	+1	GATA3,SOX9,WT1
GO:0072088	nephron epithelium morphogenesis	0.010026257800160079	0.010026257800160079	+1	GATA3,SOX9,WT1
GO:0140467	integrated stress response signaling	0.010026257800160079	0.010026257800160079	+1	NFE2L2,CEBPA,NFE2L3
GO:0003229	ventricular cardiac muscle tissue development	0.010026257800160079	0.010026257800160079	+1	NOTCH1,FGFR2,SMAD4
GO:1905330	regulation of morphogenesis of an epithelium	0.010026257800160079	0.010026257800160079	+1	GATA3,SOX9,HGF
GO:1900274	regulation of phospholipase C activity	0.010026257800160079	0.010026257800160079	+1	EGFR,KIT,PDGFRA
GO:0060349	bone morphogenesis	0.010026257800160079	0.010026257800160079	+1	SOX9,FGFR2,FGFR3
GO:0045446	endothelial cell differentiation	0.010121254377856359	0.010121254377856359	+1	NOTCH1,SMAD4,SOX17,VEZF1
GO:0010634	positive regulation of epithelial cell migration	0.010353230522445423	0.010353230522445423	+1	GATA3,AKT1,PIK3CG,SOX9,MTOR
GO:1902904	negative regulation of supramolecular fiber organization	0.010353230522445423	0.010353230522445423	+1	PIK3CA,APC,NAV3,PIK3R1,SMAD4
GO:0035710	CD4-positive, alpha-beta T cell activation	0.01052556275721833	0.01052556275721833	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0048639	positive regulation of developmental growth	0.01052556275721833	0.01052556275721833	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:1904705	regulation of vascular associated smooth muscle cell proliferation	0.010595640293552038	0.010595640293552038	+1	PTEN,CDKN1B,CDKN1A
GO:0031648	protein destabilization	0.010595640293552038	0.010595640293552038	+1	CDKN2A,EP300,SOX17
GO:0061333	renal tubule morphogenesis	0.010595640293552038	0.010595640293552038	+1	GATA3,SOX9,WT1
GO:0048844	artery morphogenesis	0.010595640293552038	0.010595640293552038	+1	NF1,NOTCH1,TGFBR2
GO:1903214	regulation of protein targeting to mitochondrion	0.010595640293552038	0.010595640293552038	+1	FBXW7,BAP1,LRRK2
GO:0045620	negative regulation of lymphocyte differentiation	0.010595640293552038	0.010595640293552038	+1	CDKN2A,RUNX1,CBFB
GO:0006984	ER-nucleus signaling pathway	0.010595640293552038	0.010595640293552038	+1	TP53,FBXW7,NFE2L2
GO:1990000	amyloid fibril formation	0.010595640293552038	0.010595640293552038	+1	VHL,CDKN2A,USP9X
GO:1990874	vascular associated smooth muscle cell proliferation	0.010595640293552038	0.010595640293552038	+1	PTEN,CDKN1B,CDKN1A
GO:0031294	lymphocyte costimulation	0.010595640293552038	0.010595640293552038	+1	PIK3CA,AKT1,PTPN11
GO:0035065	regulation of histone acetylation	0.010595640293552038	0.010595640293552038	+1	BRCA1,SMAD4,SF3B1
GO:0051403	stress-activated MAPK cascade	0.010632958393074765	0.010632958393074765	+1	EGFR,MAP2K4,LRRK2,MAPK8IP1,MECOM,NCOR1
GO:0002761	regulation of myeloid leukocyte differentiation	0.010805743151332764	0.010805743151332764	+1	FBXW7,RUNX1,MTOR,TLR4
GO:0046634	regulation of alpha-beta T cell activation	0.010805743151332764	0.010805743151332764	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:0015749	monosaccharide transmembrane transport	0.010805743151332764	0.010805743151332764	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0006110	regulation of glycolytic process	0.011269601569019884	0.011269601569019884	+1	MTOR,EP300,NCOR1
GO:1903209	positive regulation of oxidative stress-induced cell death	0.011305779378337906	0.011305779378337906	+1	FBXW7,TLR4
GO:0035272	exocrine system development	0.011305779378337906	0.011305779378337906	+1	HGF,FGFR2
GO:2000696	regulation of epithelial cell differentiation involved in kidney development	0.011305779378337906	0.011305779378337906	+1	GATA3,CTNNB1
GO:0045686	negative regulation of glial cell differentiation	0.011305779378337906	0.011305779378337906	+1	NF1,NOTCH1
GO:0034088	maintenance of mitotic sister chromatid cohesion	0.011305779378337906	0.011305779378337906	+1	RB1,ATRX
GO:0034086	maintenance of sister chromatid cohesion	0.011305779378337906	0.011305779378337906	+1	RB1,ATRX
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	0.011305779378337906	0.011305779378337906	+1	PIK3CA,PIK3CG
GO:0072160	nephron tubule epithelial cell differentiation	0.011305779378337906	0.011305779378337906	+1	GATA3,CTNNB1
GO:0007530	sex determination	0.011305779378337906	0.011305779378337906	+1	SOX9,WT1
GO:0071493	cellular response to UV-B	0.011305779378337906	0.011305779378337906	+1	STK11,CDKN1A
GO:0072224	metanephric glomerulus development	0.011305779378337906	0.011305779378337906	+1	WT1,PDGFRA
GO:1900037	regulation of cellular response to hypoxia	0.011305779378337906	0.011305779378337906	+1	VHL,AJUBA
GO:0072350	tricarboxylic acid metabolic process	0.011305779378337906	0.011305779378337906	+1	IDH1,IDH2
GO:0018394	peptidyl-lysine acetylation	0.011686515179028445	0.011686515179028445	+1	BRCA1,EP300,SMAD4,BRCA2,SF3B1
GO:0032869	cellular response to insulin stimulus	0.011686515179028445	0.011686515179028445	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0031098	stress-activated protein kinase signaling cascade	0.011762384964259527	0.011762384964259527	+1	EGFR,MAP2K4,LRRK2,MAPK8IP1,MECOM,NCOR1
GO:0043388	positive regulation of DNA binding	0.011837655268113036	0.011837655268113036	+1	GATA3,RB1,EP300
GO:0055008	cardiac muscle tissue morphogenesis	0.011837655268113036	0.011837655268113036	+1	NOTCH1,FGFR2,SMAD4
GO:0031060	regulation of histone methylation	0.011837655268113036	0.011837655268113036	+1	CTNNB1,BRCA1,SMAD4
GO:0090199	regulation of release of cytochrome c from mitochondria	0.011837655268113036	0.011837655268113036	+1	TP53,AKT1,HGF
GO:0021954	central nervous system neuron development	0.011837655268113036	0.011837655268113036	+1	PTEN,ARHGAP35,FGFR2
GO:0070997	neuron death	0.0119740907089825	0.0119740907089825	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
GO:0090263	positive regulation of canonical Wnt signaling pathway	0.01197814066900523	0.01197814066900523	+1	EGFR,LRRK2,FGFR2,TBL1XR1
GO:1902075	cellular response to salt	0.012280425726094654	0.012280425726094654	+1	PIK3CA,CDH1,BRAF,CDKN1B,TAF1
GO:0051896	regulation of protein kinase B signaling	0.012280425726094654	0.012280425726094654	+1	PIK3CA,PTEN,EGFR,GATA3,PIK3CG
GO:0007422	peripheral nervous system development	0.01256990759248355	0.01256990759248355	+1	NF1,RUNX1,PRX
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	0.01256990759248355	0.01256990759248355	+1	NOTCH1,ERBB4,KIT
GO:0010614	negative regulation of cardiac muscle hypertrophy	0.012917475026047998	0.012917475026047998	+1	NOTCH1,SMAD4
GO:0072273	metanephric nephron morphogenesis	0.012917475026047998	0.012917475026047998	+1	SOX9,WT1
GO:0030889	negative regulation of B cell proliferation	0.012917475026047998	0.012917475026047998	+1	CDKN2A,ATM
GO:0043393	regulation of protein binding	0.012917475026047998	0.012917475026047998	+1	AKT1,LRRK2,USP9X,CDKN1A,TAF1
GO:0007413	axonal fasciculation	0.012917475026047998	0.012917475026047998	+1	ARHGAP35,EPHA3
GO:0014044	Schwann cell development	0.012917475026047998	0.012917475026047998	+1	NF1,PRX
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	0.012917475026047998	0.012917475026047998	+1	NOTCH1,TGFBR2
GO:0106030	neuron projection fasciculation	0.012917475026047998	0.012917475026047998	+1	ARHGAP35,EPHA3
GO:0014741	negative regulation of muscle hypertrophy	0.012917475026047998	0.012917475026047998	+1	NOTCH1,SMAD4
GO:0060231	mesenchymal to epithelial transition	0.012917475026047998	0.012917475026047998	+1	GATA3,WT1
GO:1905475	regulation of protein localization to membrane	0.012917475026047998	0.012917475026047998	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0003188	heart valve formation	0.012917475026047998	0.012917475026047998	+1	NOTCH1,SMAD4
GO:0070314	G1 to G0 transition	0.012917475026047998	0.012917475026047998	+1	TP53,STK11
GO:0032292	peripheral nervous system axon ensheathment	0.012917475026047998	0.012917475026047998	+1	NF1,PRX
GO:0022011	myelination in peripheral nervous system	0.012917475026047998	0.012917475026047998	+1	NF1,PRX
GO:0021772	olfactory bulb development	0.012917475026047998	0.012917475026047998	+1	ERBB4,LRRK2
GO:0045444	fat cell differentiation	0.01320995507931911	0.01320995507931911	+1	GATA3,CEBPA,AKT1,EP300,ASXL1
GO:0055013	cardiac muscle cell development	0.01320995507931911	0.01320995507931911	+1	TBX3,PDGFRA,SMAD4
GO:0051216	cartilage development	0.01326491161993717	0.01326491161993717	+1	RUNX1,SOX9,FGFR3,PTPN11
GO:0046651	lymphocyte proliferation	0.013492708867606654	0.013492708867606654	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:0030178	negative regulation of Wnt signaling pathway	0.013547448197552329	0.013547448197552329	+1	APC,STK11,SOX9,SOX17,AXIN2
GO:1905477	positive regulation of protein localization to membrane	0.013757966216267544	0.013757966216267544	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:0042063	gliogenesis	0.013900371453527969	0.013900371453527969	+1	PTEN,NF1,NOTCH1,SOX9,PRX
GO:0106106	cold-induced thermogenesis	0.013900371453527969	0.013900371453527969	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0120161	regulation of cold-induced thermogenesis	0.013900371453527969	0.013900371453527969	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0060079	excitatory postsynaptic potential	0.013934791876732987	0.013934791876732987	+1	PTEN,AKT1,LRRK2
GO:0032873	negative regulation of stress-activated MAPK cascade	0.013934791876732987	0.013934791876732987	+1	MAPK8IP1,MECOM,NCOR1
GO:0070303	negative regulation of stress-activated protein kinase signaling cascade	0.013934791876732987	0.013934791876732987	+1	MAPK8IP1,MECOM,NCOR1
GO:0045670	regulation of osteoclast differentiation	0.013934791876732987	0.013934791876732987	+1	FBXW7,MTOR,TLR4
GO:0034219	carbohydrate transmembrane transport	0.014213359789134327	0.014213359789134327	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0006403	RNA localization	0.014234813736655185	0.014234813736655185	+1	NPM1,ATM,SETD2,TGFBR2,ATR
GO:0032943	mononuclear cell proliferation	0.014316469150977281	0.014316469150977281	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:0010038	response to metal ion	0.014635820843308996	0.014635820843308996	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:1904894	positive regulation of receptor signaling pathway via STAT	0.014665741440586102	0.014665741440586102	+1	NOTCH1,ERBB4,KIT
GO:0035107	appendage morphogenesis	0.014665741440586102	0.014665741440586102	+1	CTNNB1,TBX3,FGFR2
GO:0035108	limb morphogenesis	0.014665741440586102	0.014665741440586102	+1	CTNNB1,TBX3,FGFR2
GO:1903747	regulation of establishment of protein localization to mitochondrion	0.014665741440586102	0.014665741440586102	+1	FBXW7,BAP1,LRRK2
GO:0072207	metanephric epithelium development	0.014665741440586102	0.014665741440586102	+1	SOX9,WT1
GO:0071300	cellular response to retinoic acid	0.014665741440586102	0.014665741440586102	+1	EPHA3,SOX9,ATM
GO:0016578	histone deubiquitination	0.014665741440586102	0.014665741440586102	+1	BAP1,BRCA1,ASXL1
GO:0048385	regulation of retinoic acid receptor signaling pathway	0.014665741440586102	0.014665741440586102	+1	ASXL1,EZH2
GO:0021988	olfactory lobe development	0.014665741440586102	0.014665741440586102	+1	ERBB4,LRRK2
GO:0008643	carbohydrate transport	0.015188008851653952	0.015188008851653952	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0050866	negative regulation of cell activation	0.015332713574750623	0.015332713574750623	+1	CDKN2A,RUNX1,ATM,PDGFRA,CBFB
GO:0048644	muscle organ morphogenesis	0.015452947348613372	0.015452947348613372	+1	NOTCH1,FGFR2,SMAD4
GO:0006306	DNA methylation	0.015452947348613372	0.015452947348613372	+1	DNMT3A,WT1,ATRX
GO:2000756	regulation of peptidyl-lysine acetylation	0.015452947348613372	0.015452947348613372	+1	BRCA1,SMAD4,SF3B1
GO:0060840	artery development	0.015452947348613372	0.015452947348613372	+1	NF1,NOTCH1,TGFBR2
GO:0044818	mitotic G2/M transition checkpoint	0.015452947348613372	0.015452947348613372	+1	ATM,BRCA1,CDKN1A
GO:0060415	muscle tissue morphogenesis	0.015452947348613372	0.015452947348613372	+1	NOTCH1,FGFR2,SMAD4
GO:0006305	DNA alkylation	0.015452947348613372	0.015452947348613372	+1	DNMT3A,WT1,ATRX
GO:0002042	cell migration involved in sprouting angiogenesis	0.015452947348613372	0.015452947348613372	+1	NOTCH1,AKT1,EGR3
GO:0006334	nucleosome assembly	0.01563564725711061	0.01563564725711061	+1	NPM1,SOX9,ATRX,HIST1H2BD
GO:0032868	response to insulin	0.01563564725711061	0.01563564725711061	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:1902850	microtubule cytoskeleton organization involved in mitosis	0.016035575242812575	0.016035575242812575	+1	STAG2,CHEK2,SETD2,SMC1A,SMC3
GO:0120034	positive regulation of plasma membrane bounded cell projection assembly	0.016173415251024892	0.016173415251024892	+1	PIK3CA,APC,PIK3R1,ARHGAP35
GO:0043966	histone H3 acetylation	0.016301277721948153	0.016301277721948153	+1	BRCA1,SMAD4,BRCA2
GO:0006103	2-oxoglutarate metabolic process	0.016481603755090866	0.016481603755090866	+1	IDH1,IDH2
GO:0032331	negative regulation of chondrocyte differentiation	0.016481603755090866	0.016481603755090866	+1	SOX9,PTPN11
GO:0072111	cell proliferation involved in kidney development	0.016481603755090866	0.016481603755090866	+1	GATA3,WT1
GO:2000678	negative regulation of transcription regulatory region DNA binding	0.016481603755090866	0.016481603755090866	+1	TAF1,SIN3A
GO:0035162	embryonic hemopoiesis	0.016481603755090866	0.016481603755090866	+1	KIT,TGFBR2
GO:0010165	response to X-ray	0.016481603755090866	0.016481603755090866	+1	GATA3,ATM
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	0.016481603755090866	0.016481603755090866	+1	NFE2L2,SMAD4
GO:0035994	response to muscle stretch	0.016481603755090866	0.016481603755090866	+1	PIK3CA,CTNNB1
GO:0010594	regulation of endothelial cell migration	0.016771691000958155	0.016771691000958155	+1	NF1,GATA3,NOTCH1,AKT1,PIK3CG
GO:0032886	regulation of microtubule-based process	0.01696033317790953	0.01696033317790953	+1	APC,NAV3,NPM1,STK11,EPHA3,BRCA1
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	0.017102351122673866	0.017102351122673866	+1	SMAD4,TGFBR2,ACVR2A
GO:1990845	adaptive thermogenesis	0.01765869448260254	0.01765869448260254	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0051897	positive regulation of protein kinase B signaling	0.017812656889761122	0.017812656889761122	+1	PIK3CA,EGFR,GATA3,PIK3CG
GO:0046323	glucose import	0.018009789937131516	0.018009789937131516	+1	PIK3R1,AKT1,PTPN11
GO:0046854	phosphatidylinositol phosphate biosynthetic process	0.018009789937131516	0.018009789937131516	+1	PIK3CA,PIK3R1,PIK3CG
GO:0038093	Fc receptor signaling pathway	0.018009789937131516	0.018009789937131516	+1	MAP3K1,MAP2K4,KIT
GO:0043534	blood vessel endothelial cell migration	0.018369859708800174	0.018369859708800174	+1	NF1,NOTCH1,AKT1,EGR3
GO:0001952	regulation of cell-matrix adhesion	0.018369859708800174	0.018369859708800174	+1	PTEN,NF1,CDKN2A,EPHA3
GO:0061037	negative regulation of cartilage development	0.018381114429188328	0.018381114429188328	+1	SOX9,PTPN11
GO:0048854	brain morphogenesis	0.018381114429188328	0.018381114429188328	+1	PTEN,NF1
GO:0003338	metanephros morphogenesis	0.018381114429188328	0.018381114429188328	+1	SOX9,WT1
GO:0110110	positive regulation of animal organ morphogenesis	0.018381114429188328	0.018381114429188328	+1	GATA3,SOX9
GO:0038092	nodal signaling pathway	0.018381114429188328	0.018381114429188328	+1	ACVR1B,SMAD2
GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	0.018381114429188328	0.018381114429188328	+1	RUNX1,CBFB
GO:0002320	lymphoid progenitor cell differentiation	0.018381114429188328	0.018381114429188328	+1	NOTCH1,FLT3
GO:0001569	branching involved in blood vessel morphogenesis	0.018381114429188328	0.018381114429188328	+1	CTNNB1,TGFBR2
GO:0043433	negative regulation of DNA-binding transcription factor activity	0.018381114429188328	0.018381114429188328	+1	CDKN2A,RB1,KEAP1,FOXA2,TAF1
GO:0072012	glomerulus vasculature development	0.018381114429188328	0.018381114429188328	+1	WT1,PDGFRA
GO:0046635	positive regulation of alpha-beta T cell activation	0.018742451196352306	0.018742451196352306	+1	RUNX1,TGFBR2,CBFB
GO:0070373	negative regulation of ERK1 and ERK2 cascade	0.018742451196352306	0.018742451196352306	+1	PTEN,TLR4,SMAD4
GO:0006383	transcription by RNA polymerase III	0.018742451196352306	0.018742451196352306	+1	AR,MTOR,SF3B1
GO:0001836	release of cytochrome c from mitochondria	0.018742451196352306	0.018742451196352306	+1	TP53,AKT1,HGF
GO:0099565	chemical synaptic transmission, postsynaptic	0.018742451196352306	0.018742451196352306	+1	PTEN,AKT1,LRRK2
GO:0021537	telencephalon development	0.0187681962451263	0.0187681962451263	+1	PTEN,NF1,ERBB4,LRRK2
GO:0009952	anterior/posterior pattern specification	0.01930984460893909	0.01930984460893909	+1	TBX3,WT1,FOXA2,SMAD2
GO:0038061	NIK/NF-kappaB signaling	0.01930984460893909	0.01930984460893909	+1	EGFR,AKT1,TLR4,EP300
GO:0032006	regulation of TOR signaling	0.01930984460893909	0.01930984460893909	+1	PIK3CA,STK11,ATM,USP9X
GO:0030856	regulation of epithelial cell differentiation	0.01930984460893909	0.01930984460893909	+1	GATA3,CTNNB1,SOX9,VEZF1
GO:0001659	temperature homeostasis	0.019572238581185272	0.019572238581185272	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0046637	regulation of alpha-beta T cell differentiation	0.019595724667517654	0.019595724667517654	+1	RUNX1,TGFBR2,CBFB
GO:0031398	positive regulation of protein ubiquitination	0.019891771184549423	0.019891771184549423	+1	PTEN,FBXW7,BRCA1,LRRK2
GO:1903038	negative regulation of leukocyte cell-cell adhesion	0.019891771184549423	0.019891771184549423	+1	CDKN2A,RUNX1,AKT1,CBFB
GO:0071356	cellular response to tumor necrosis factor	0.020001041847512054	0.020001041847512054	+1	TP53,GATA3,NFE2L2,AKT1,BRCA1
GO:0007252	I-kappaB phosphorylation	0.020207415872545768	0.020207415872545768	+1	AKT1,TLR4
GO:0010224	response to UV-B	0.020207415872545768	0.020207415872545768	+1	STK11,CDKN1A
GO:0055003	cardiac myofibril assembly	0.020207415872545768	0.020207415872545768	+1	PDGFRA,SMAD4
GO:0061437	renal system vasculature development	0.020207415872545768	0.020207415872545768	+1	WT1,PDGFRA
GO:0090201	negative regulation of release of cytochrome c from mitochondria	0.020207415872545768	0.020207415872545768	+1	AKT1,HGF
GO:0071425	hematopoietic stem cell proliferation	0.020207415872545768	0.020207415872545768	+1	RUNX1,MECOM
GO:0061440	kidney vasculature development	0.020207415872545768	0.020207415872545768	+1	WT1,PDGFRA
GO:1903203	regulation of oxidative stress-induced neuron death	0.020207415872545768	0.020207415872545768	+1	FBXW7,TLR4
GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	0.020207415872545768	0.020207415872545768	+1	VHL,PPP2R1A
GO:0014037	Schwann cell differentiation	0.020207415872545768	0.020207415872545768	+1	NF1,PRX
GO:0043032	positive regulation of macrophage activation	0.020207415872545768	0.020207415872545768	+1	CEBPA,TLR4
GO:0032204	regulation of telomere maintenance	0.020336711662258655	0.020336711662258655	+1	CTNNB1,ATM,ATRX,ATR
GO:1901224	positive regulation of NIK/NF-kappaB signaling	0.020336711662258655	0.020336711662258655	+1	EGFR,TLR4,EP300
GO:0002520	immune system development	0.020336711662258655	0.020336711662258655	+1	TP53,GATA3,POLQ,TGFBR2
GO:0032210	regulation of telomere maintenance via telomerase	0.020336711662258655	0.020336711662258655	+1	CTNNB1,ATM,ATR
GO:0010812	negative regulation of cell-substrate adhesion	0.020336711662258655	0.020336711662258655	+1	PTEN,CDKN2A,NOTCH1
GO:0002274	myeloid leukocyte activation	0.02054199170102029	0.02054199170102029	+1	CEBPA,PIK3CG,TLR4,KIT,TGFBR2
GO:0000209	protein polyubiquitination	0.02054199170102029	0.02054199170102029	+1	CDKN2A,CTNNB1,BRCA1,TAF1,CBFB,SPOP
GO:0010810	regulation of cell-substrate adhesion	0.02054199170102029	0.02054199170102029	+1	PTEN,NF1,CDKN2A,NOTCH1,EPHA3
GO:0010565	regulation of cellular ketone metabolic process	0.02054199170102029	0.02054199170102029	+1	AKT1,SOX9,BRCA1,NCOR1
GO:1901880	negative regulation of protein depolymerization	0.02054199170102029	0.02054199170102029	+1	PIK3CA,APC,NAV3
GO:0000724	double-strand break repair via homologous recombination	0.020690771084191286	0.020690771084191286	+1	BRCA1,POLQ,SETD2,BRCA2,RAD21
GO:0014014	negative regulation of gliogenesis	0.020690771084191286	0.020690771084191286	+1	NF1,NOTCH1
GO:2000243	positive regulation of reproductive process	0.020690771084191286	0.020690771084191286	+1	SOX9,WT1,ACVR1B
GO:0006098	pentose-phosphate shunt	0.020690771084191286	0.020690771084191286	+1	TP53,MTOR
GO:2000811	negative regulation of anoikis	0.020690771084191286	0.020690771084191286	+1	PIK3CA,NOTCH1
GO:0016331	morphogenesis of embryonic epithelium	0.020690771084191286	0.020690771084191286	+1	GATA3,SOX9,FGFR2
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.020690771084191286	0.020690771084191286	+1	NFE2L2,AKT1
GO:0070102	interleukin-6-mediated signaling pathway	0.020690771084191286	0.020690771084191286	+1	CEBPA,SMAD4
GO:0070723	response to cholesterol	0.020690771084191286	0.020690771084191286	+1	TGFBR2,SMAD2
GO:0035313	wound healing, spreading of epidermal cells	0.020690771084191286	0.020690771084191286	+1	PTEN,MTOR
GO:0061647	histone H3-K9 modification	0.020690771084191286	0.020690771084191286	+1	BRCA1,SMAD4
GO:0030198	extracellular matrix organization	0.02154086815499166	0.02154086815499166	+1	NF1,RB1,NOTCH1,RUNX1,WT1,AXIN2
GO:0070301	cellular response to hydrogen peroxide	0.021669698505456796	0.021669698505456796	+1	NFE2L2,HGF,LRRK2
GO:0072175	epithelial tube formation	0.021669698505456796	0.021669698505456796	+1	GATA3,SOX9,FGFR2
GO:0030183	B cell differentiation	0.02188721474951309	0.02188721474951309	+1	PIK3R1,FLT3,ATM,KIT
GO:0043062	extracellular structure organization	0.021889007745100695	0.021889007745100695	+1	NF1,RB1,NOTCH1,RUNX1,WT1,AXIN2
GO:0000725	recombinational repair	0.021985212572830724	0.021985212572830724	+1	BRCA1,POLQ,SETD2,BRCA2,RAD21
GO:0048147	negative regulation of fibroblast proliferation	0.02249208906324279	0.02249208906324279	+1	TP53,NF1
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	0.02249208906324279	0.02249208906324279	+1	ATM,BRCA1,CDKN1A
GO:0003184	pulmonary valve morphogenesis	0.02249208906324279	0.02249208906324279	+1	NOTCH1,SMAD2
GO:1902894	negative regulation of miRNA transcription	0.02249208906324279	0.02249208906324279	+1	SOX9,NCOR1
GO:1905207	regulation of cardiocyte differentiation	0.02249208906324279	0.02249208906324279	+1	EGFR,SMAD4
GO:0031056	regulation of histone modification	0.02249208906324279	0.02249208906324279	+1	CTNNB1,BRCA1,SMAD4,SF3B1
GO:0048713	regulation of oligodendrocyte differentiation	0.02249208906324279	0.02249208906324279	+1	NF1,NOTCH1
GO:0045229	external encapsulating structure organization	0.02249208906324279	0.02249208906324279	+1	NF1,RB1,NOTCH1,RUNX1,WT1,AXIN2
GO:0097306	cellular response to alcohol	0.02249208906324279	0.02249208906324279	+1	CTNNB1,CDH1,BRCA1
GO:0030277	maintenance of gastrointestinal epithelium	0.02249208906324279	0.02249208906324279	+1	SOX9,TLR4
GO:0032481	positive regulation of type I interferon production	0.02249208906324279	0.02249208906324279	+1	TLR4,SETD2,PTPN11
GO:0036475	neuron death in response to oxidative stress	0.02249208906324279	0.02249208906324279	+1	FBXW7,TLR4
GO:0035518	histone H2A monoubiquitination	0.02249208906324279	0.02249208906324279	+1	BRCA1,BRCA2
GO:1902115	regulation of organelle assembly	0.02249208906324279	0.02249208906324279	+1	ARHGAP35,NPM1,BRCA1,LRRK2,SMAD4
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	0.02249208906324279	0.02249208906324279	+1	TP53,NFE2L2
GO:0007350	blastoderm segmentation	0.02249208906324279	0.02249208906324279	+1	TBX3,WT1
GO:0001655	urogenital system development	0.02249208906324279	0.02249208906324279	+1	SOX9,FGFR2
GO:0051444	negative regulation of ubiquitin-protein transferase activity	0.02249208906324279	0.02249208906324279	+1	CDKN2A,RPL5
GO:0007351	tripartite regional subdivision	0.02249208906324279	0.02249208906324279	+1	TBX3,WT1
GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	0.02249208906324279	0.02249208906324279	+1	RUNX1,TGFBR2,CBFB
GO:0008595	anterior/posterior axis specification, embryo	0.02249208906324279	0.02249208906324279	+1	TBX3,WT1
GO:0006360	transcription by RNA polymerase I	0.02249208906324279	0.02249208906324279	+1	MTOR,SF3B1,TAF1
GO:0060350	endochondral bone morphogenesis	0.02249208906324279	0.02249208906324279	+1	SOX9,FGFR3
GO:0031669	cellular response to nutrient levels	0.02262229974123516	0.02262229974123516	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A
GO:0032388	positive regulation of intracellular transport	0.02262229974123516	0.02262229974123516	+1	PIK3R1,FBXW7,CDH1,BAP1,STK11
GO:0006473	protein acetylation	0.02262229974123516	0.02262229974123516	+1	BRCA1,EP300,SMAD4,BRCA2,SF3B1
GO:0051250	negative regulation of lymphocyte activation	0.02282634311989231	0.02282634311989231	+1	CDKN2A,RUNX1,ATM,CBFB
GO:0030032	lamellipodium assembly	0.023265658286438857	0.023265658286438857	+1	PIK3CA,PIK3R1,KIT
GO:0010965	regulation of mitotic sister chromatid separation	0.023265658286438857	0.023265658286438857	+1	APC,RB1,ATM
GO:0038202	TORC1 signaling	0.023265658286438857	0.023265658286438857	+1	STK11,ATM,MTOR
GO:0007051	spindle organization	0.023598072095956244	0.023598072095956244	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:2001236	regulation of extrinsic apoptotic signaling pathway	0.02415221225236549	0.02415221225236549	+1	PTEN,AKT1,AR,BRCA1
GO:0030168	platelet activation	0.02415221225236549	0.02415221225236549	+1	PIK3CA,PIK3CG,TLR4,PDGFRA
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	0.02426506703352739	0.02426506703352739	+1	TP53,STK11,EP300
GO:0048839	inner ear development	0.02426506703352739	0.02426506703352739	+1	SOX9,FGFR2,PTPN11
GO:2000736	regulation of stem cell differentiation	0.02426506703352739	0.02426506703352739	+1	NOTCH1,SOX9,PDGFRA
GO:1902750	negative regulation of cell cycle G2/M phase transition	0.02426506703352739	0.02426506703352739	+1	ATM,BRCA1,CDKN1A
GO:2000434	regulation of protein neddylation	0.024508892713669978	0.024508892713669978	+1	CDKN2A,RPL5
GO:0034405	response to fluid shear stress	0.024508892713669978	0.024508892713669978	+1	NFE2L2,AKT1
GO:2000629	negative regulation of miRNA metabolic process	0.024508892713669978	0.024508892713669978	+1	SOX9,NCOR1
GO:1904893	negative regulation of receptor signaling pathway via STAT	0.024508892713669978	0.024508892713669978	+1	VHL,PPP2R1A
GO:0048566	embryonic digestive tract development	0.024508892713669978	0.024508892713669978	+1	PDGFRA,FGFR2
GO:0072659	protein localization to plasma membrane	0.02468122739578989	0.02468122739578989	+1	EGFR,PIK3R1,CDH1,EPHA3,AKT1,AR
GO:0150116	regulation of cell-substrate junction organization	0.025215100960206415	0.025215100960206415	+1	PTEN,PIK3R1,EPHA3
GO:0051306	mitotic sister chromatid separation	0.025215100960206415	0.025215100960206415	+1	APC,RB1,ATM
GO:1901983	regulation of protein acetylation	0.025215100960206415	0.025215100960206415	+1	BRCA1,SMAD4,SF3B1
GO:0007369	gastrulation	0.025362921856690267	0.025362921856690267	+1	SETD2,FOXA2,SOX17,SMAD2
GO:0072655	establishment of protein localization to mitochondrion	0.025362921856690267	0.025362921856690267	+1	FBXW7,BAP1,AKT1,LRRK2
GO:0050878	regulation of body fluid levels	0.025478006460906668	0.025478006460906668	+1	PIK3CA,PIK3CG,ERBB4,TLR4,PDGFRA,FOXA2
GO:0007596	blood coagulation	0.02548601455669171	0.02548601455669171	+1	PIK3CA,PIK3CG,TLR4,PDGFRA,FOXA2
GO:0034612	response to tumor necrosis factor	0.02548601455669171	0.02548601455669171	+1	TP53,GATA3,NFE2L2,AKT1,BRCA1
GO:0007517	muscle organ development	0.02602481375663795	0.02602481375663795	+1	NOTCH1,WT1,FGFR2,SMAD4,EGR3
GO:0030177	positive regulation of Wnt signaling pathway	0.02602481375663795	0.02602481375663795	+1	EGFR,LRRK2,FGFR2,TBL1XR1
GO:0070988	demethylation	0.026181323224162643	0.026181323224162643	+1	KDM6A,TET2,USP9X
GO:0060541	respiratory system development	0.026181323224162643	0.026181323224162643	+1	CEBPA,WT1,FGFR2
GO:0060078	regulation of postsynaptic membrane potential	0.026181323224162643	0.026181323224162643	+1	PTEN,AKT1,LRRK2
GO:0033233	regulation of protein sumoylation	0.026516983056941418	0.026516983056941418	+1	CDKN2A,CTNNB1
GO:1903055	positive regulation of extracellular matrix organization	0.026516983056941418	0.026516983056941418	+1	RB1,RUNX1
GO:0001709	cell fate determination	0.026516983056941418	0.026516983056941418	+1	GATA3,SOX17
GO:0046639	negative regulation of alpha-beta T cell differentiation	0.026516983056941418	0.026516983056941418	+1	RUNX1,CBFB
GO:0098751	bone cell development	0.026516983056941418	0.026516983056941418	+1	FBXW7,KIT
GO:0006740	NADPH regeneration	0.026516983056941418	0.026516983056941418	+1	TP53,MTOR
GO:0035825	homologous recombination	0.027144920872209422	0.027144920872209422	+1	ATM,BRCA1,RAD21
GO:0061045	negative regulation of wound healing	0.027144920872209422	0.027144920872209422	+1	PTEN,EPPK1,PDGFRA
GO:1904356	regulation of telomere maintenance via telomere lengthening	0.027144920872209422	0.027144920872209422	+1	CTNNB1,ATM,ATR
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	0.027144920872209422	0.027144920872209422	+1	SMAD4,TGFBR2,ACVR2A
GO:0032092	positive regulation of protein binding	0.027144920872209422	0.027144920872209422	+1	LRRK2,USP9X,TAF1
GO:0032200	telomere organization	0.027498332178698175	0.027498332178698175	+1	CTNNB1,ATM,ATRX,ATR,EZH2
GO:0050817	coagulation	0.027498332178698175	0.027498332178698175	+1	PIK3CA,PIK3CG,TLR4,PDGFRA,FOXA2
GO:0046328	regulation of JNK cascade	0.028028978205342725	0.028028978205342725	+1	EGFR,MAPK8IP1,MECOM,NCOR1
GO:0055001	muscle cell development	0.028028978205342725	0.028028978205342725	+1	NOTCH1,TBX3,PDGFRA,SMAD4
GO:0010633	negative regulation of epithelial cell migration	0.028219089466993974	0.028219089466993974	+1	PTEN,NOTCH1,EPPK1
GO:0021782	glial cell development	0.028219089466993974	0.028219089466993974	+1	PTEN,NF1,PRX
GO:0070585	protein localization to mitochondrion	0.028591852235493834	0.028591852235493834	+1	FBXW7,BAP1,AKT1,LRRK2
GO:0021955	central nervous system neuron axonogenesis	0.028591852235493834	0.028591852235493834	+1	PTEN,ARHGAP35
GO:0030851	granulocyte differentiation	0.028591852235493834	0.028591852235493834	+1	RUNX1,CEBPA
GO:0051150	regulation of smooth muscle cell differentiation	0.028591852235493834	0.028591852235493834	+1	KIT,FGFR2
GO:0045671	negative regulation of osteoclast differentiation	0.028591852235493834	0.028591852235493834	+1	FBXW7,TLR4
GO:0007599	hemostasis	0.028591852235493834	0.028591852235493834	+1	PIK3CA,PIK3CG,TLR4,PDGFRA,FOXA2
GO:0018027	peptidyl-lysine dimethylation	0.028591852235493834	0.028591852235493834	+1	SETBP1,SETD2
GO:0035315	hair cell differentiation	0.028591852235493834	0.028591852235493834	+1	CTNNB1,ERCC2
GO:0032069	regulation of nuclease activity	0.028591852235493834	0.028591852235493834	+1	NPM1,AKT1
GO:0035886	vascular associated smooth muscle cell differentiation	0.028591852235493834	0.028591852235493834	+1	NOTCH1,KIT
GO:0010906	regulation of glucose metabolic process	0.02919474472254511	0.02919474472254511	+1	AKT1,EP300,FOXA2
GO:0043367	CD4-positive, alpha-beta T cell differentiation	0.02919474472254511	0.02919474472254511	+1	GATA3,RUNX1,CBFB
GO:0008361	regulation of cell size	0.030194754085099005	0.030194754085099005	+1	PTEN,ARHGAP35,MTOR,SIN3A
GO:0043242	negative regulation of protein-containing complex disassembly	0.030407714805119165	0.030407714805119165	+1	PIK3CA,APC,NAV3
GO:0006661	phosphatidylinositol biosynthetic process	0.03080114027049717	0.03080114027049717	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
GO:0036314	response to sterol	0.03080114027049717	0.03080114027049717	+1	TGFBR2,SMAD2
GO:2000209	regulation of anoikis	0.03080114027049717	0.03080114027049717	+1	PIK3CA,NOTCH1
GO:0001936	regulation of endothelial cell proliferation	0.03080114027049717	0.03080114027049717	+1	NF1,NRAS,AKT1,EGR3
GO:0046599	regulation of centriole replication	0.03080114027049717	0.03080114027049717	+1	NPM1,BRCA1
GO:0003177	pulmonary valve development	0.03080114027049717	0.03080114027049717	+1	NOTCH1,SMAD2
GO:0032727	positive regulation of interferon-alpha production	0.03080114027049717	0.03080114027049717	+1	TLR4,SETD2
GO:0140747	regulation of ncRNA transcription	0.03080114027049717	0.03080114027049717	+1	MTOR,ATRX
GO:2000001	regulation of DNA damage checkpoint	0.03080114027049717	0.03080114027049717	+1	BRCA1,BRCA2
GO:0038095	Fc-epsilon receptor signaling pathway	0.03080114027049717	0.03080114027049717	+1	MAP3K1,MAP2K4
GO:0071404	cellular response to low-density lipoprotein particle stimulus	0.03080114027049717	0.03080114027049717	+1	AKT1,TLR4
GO:0070168	negative regulation of biomineral tissue development	0.03080114027049717	0.03080114027049717	+1	NOTCH1,SOX9
GO:0060389	pathway-restricted SMAD protein phosphorylation	0.03139413178874879	0.03139413178874879	+1	SMAD4,TGFBR2,ACVR2A
GO:0016052	carbohydrate catabolic process	0.03157548173926697	0.03157548173926697	+1	TP53,MTOR,EP300,NCOR1
GO:0042542	response to hydrogen peroxide	0.03265190767260514	0.03265190767260514	+1	NFE2L2,HGF,LRRK2
GO:0010592	positive regulation of lamellipodium assembly	0.03317759250251507	0.03317759250251507	+1	PIK3CA,PIK3R1
GO:0007052	mitotic spindle organization	0.03317759250251507	0.03317759250251507	+1	STAG2,CHEK2,SMC1A,SMC3
GO:0010669	epithelial structure maintenance	0.03317759250251507	0.03317759250251507	+1	SOX9,TLR4
GO:0048384	retinoic acid receptor signaling pathway	0.03317759250251507	0.03317759250251507	+1	ASXL1,EZH2
GO:0055094	response to lipoprotein particle	0.03317759250251507	0.03317759250251507	+1	AKT1,TLR4
GO:0061311	cell surface receptor signaling pathway involved in heart development	0.03317759250251507	0.03317759250251507	+1	NOTCH1,CTNNB1
GO:0002067	glandular epithelial cell differentiation	0.03317759250251507	0.03317759250251507	+1	AKT1,FGFR2
GO:2000108	positive regulation of leukocyte apoptotic process	0.03317759250251507	0.03317759250251507	+1	TP53,CDKN2A
GO:1902074	response to salt	0.03370575691305119	0.03370575691305119	+1	PIK3CA,CDH1,BRAF,CDKN1B,TAF1
GO:1901879	regulation of protein depolymerization	0.03373439616807002	0.03373439616807002	+1	PIK3CA,APC,NAV3
GO:1905332	positive regulation of morphogenesis of an epithelium	0.034858798209907046	0.034858798209907046	+1	GATA3,SOX9
GO:0007098	centrosome cycle	0.034858798209907046	0.034858798209907046	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:0007004	telomere maintenance via telomerase	0.034858798209907046	0.034858798209907046	+1	CTNNB1,ATM,ATR
GO:0048736	appendage development	0.034858798209907046	0.034858798209907046	+1	CTNNB1,TBX3,FGFR2
GO:0007026	negative regulation of microtubule depolymerization	0.034858798209907046	0.034858798209907046	+1	APC,NAV3
GO:0006278	RNA-templated DNA biosynthetic process	0.034858798209907046	0.034858798209907046	+1	CTNNB1,ATM,ATR
GO:2000352	negative regulation of endothelial cell apoptotic process	0.034858798209907046	0.034858798209907046	+1	GATA3,NFE2L2
GO:0071402	cellular response to lipoprotein particle stimulus	0.034858798209907046	0.034858798209907046	+1	AKT1,TLR4
GO:0060173	limb development	0.034858798209907046	0.034858798209907046	+1	CTNNB1,TBX3,FGFR2
GO:0050869	negative regulation of B cell activation	0.034858798209907046	0.034858798209907046	+1	CDKN2A,ATM
GO:0071375	cellular response to peptide hormone stimulus	0.034858798209907046	0.034858798209907046	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0048588	developmental cell growth	0.034858798209907046	0.034858798209907046	+1	CTNNB1,SOX9,USP9X,SIN3A
GO:0030901	midbrain development	0.034858798209907046	0.034858798209907046	+1	CTNNB1,FGFR2,TAF1
GO:0030316	osteoclast differentiation	0.034858798209907046	0.034858798209907046	+1	FBXW7,MTOR,TLR4
GO:1902751	positive regulation of cell cycle G2/M phase transition	0.034858798209907046	0.034858798209907046	+1	NPM1,CCND1
GO:1903533	regulation of protein targeting	0.034858798209907046	0.034858798209907046	+1	FBXW7,BAP1,LRRK2
GO:0051298	centrosome duplication	0.034858798209907046	0.034858798209907046	+1	NPM1,BRCA1,BRCA2
GO:0045739	positive regulation of DNA repair	0.035465142096975925	0.035465142096975925	+1	ARID1A,PBRM1,EGFR,BRCA1
GO:0045648	positive regulation of erythrocyte differentiation	0.036225017491360194	0.036225017491360194	+1	ACVR1B,ACVR2A
GO:0090316	positive regulation of intracellular protein transport	0.036225017491360194	0.036225017491360194	+1	PIK3R1,FBXW7,CDH1,BAP1
GO:0033146	regulation of intracellular estrogen receptor signaling pathway	0.036225017491360194	0.036225017491360194	+1	BRCA1,FOXA1
GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	0.036225017491360194	0.036225017491360194	+1	RUNX1,CBFB
GO:1904262	negative regulation of TORC1 signaling	0.036225017491360194	0.036225017491360194	+1	STK11,ATM
GO:0010837	regulation of keratinocyte proliferation	0.036225017491360194	0.036225017491360194	+1	EPPK1,FGFR2
GO:0046890	regulation of lipid biosynthetic process	0.036225017491360194	0.036225017491360194	+1	FBXW7,AKT1,MTOR,BRCA1
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	0.036740384131846535	0.036740384131846535	+1	AKT1,AR,BRCA1
GO:1905818	regulation of chromosome separation	0.036740384131846535	0.036740384131846535	+1	APC,RB1,ATM
GO:0006096	glycolytic process	0.036740384131846535	0.036740384131846535	+1	MTOR,EP300,NCOR1
GO:0002695	negative regulation of leukocyte activation	0.03797955192524093	0.03797955192524093	+1	CDKN2A,RUNX1,ATM,CBFB
GO:0097581	lamellipodium organization	0.03802282208239562	0.03802282208239562	+1	PIK3CA,PIK3R1,KIT
GO:1903035	negative regulation of response to wounding	0.03802282208239562	0.03802282208239562	+1	PTEN,EPPK1,PDGFRA
GO:0031018	endocrine pancreas development	0.03858286776487957	0.03858286776487957	+1	AKT1,FOXA2
GO:0046320	regulation of fatty acid oxidation	0.03858286776487957	0.03858286776487957	+1	AKT1,SOX9
GO:0030279	negative regulation of ossification	0.03858286776487957	0.03858286776487957	+1	NOTCH1,SOX9
GO:0051156	glucose 6-phosphate metabolic process	0.03858286776487957	0.03858286776487957	+1	TP53,MTOR
GO:2000819	regulation of nucleotide-excision repair	0.03858286776487957	0.03858286776487957	+1	ARID1A,PBRM1
GO:0009267	cellular response to starvation	0.03871968011769459	0.03871968011769459	+1	TP53,MTOR,LRRK2,CDKN1A
GO:0071887	leukocyte apoptotic process	0.03920677387242699	0.03920677387242699	+1	TP53,CDKN2A,AKT1
GO:0042552	myelination	0.03920677387242699	0.03920677387242699	+1	PTEN,NF1,PRX
GO:0001935	endothelial cell proliferation	0.03961186128676506	0.03961186128676506	+1	NF1,NRAS,AKT1,EGR3
GO:0042593	glucose homeostasis	0.04052992946962073	0.04052992946962073	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:1905897	regulation of response to endoplasmic reticulum stress	0.04052992946962073	0.04052992946962073	+1	PIK3R1,NFE2L2,LRRK2
GO:0045639	positive regulation of myeloid cell differentiation	0.04052992946962073	0.04052992946962073	+1	RUNX1,ACVR1B,ACVR2A
GO:0035767	endothelial cell chemotaxis	0.040953423590908734	0.040953423590908734	+1	NOTCH1,EGR3
GO:0060765	regulation of androgen receptor signaling pathway	0.040953423590908734	0.040953423590908734	+1	EP300,NCOR1
GO:0032330	regulation of chondrocyte differentiation	0.040953423590908734	0.040953423590908734	+1	SOX9,PTPN11
GO:0071276	cellular response to cadmium ion	0.040953423590908734	0.040953423590908734	+1	EGFR,AKT1
GO:0032607	interferon-alpha production	0.040953423590908734	0.040953423590908734	+1	TLR4,SETD2
GO:0032647	regulation of interferon-alpha production	0.040953423590908734	0.040953423590908734	+1	TLR4,SETD2
GO:0042307	positive regulation of protein import into nucleus	0.040953423590908734	0.040953423590908734	+1	PIK3R1,CDH1
GO:0033522	histone H2A ubiquitination	0.040953423590908734	0.040953423590908734	+1	BRCA1,BRCA2
GO:0045116	protein neddylation	0.040953423590908734	0.040953423590908734	+1	CDKN2A,RPL5
GO:0006470	protein dephosphorylation	0.04151698870575354	0.04151698870575354	+1	PTEN,STK11,MTOR,PPP2R1A,PTPN11
GO:0007272	ensheathment of neurons	0.04164600493118214	0.04164600493118214	+1	PTEN,NF1,PRX
GO:0006446	regulation of translational initiation	0.04164600493118214	0.04164600493118214	+1	NPM1,MTOR,EIF4A2
GO:0008366	axon ensheathment	0.04164600493118214	0.04164600493118214	+1	PTEN,NF1,PRX
GO:0033500	carbohydrate homeostasis	0.042152441964257825	0.042152441964257825	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:0051304	chromosome separation	0.04300618317083747	0.04300618317083747	+1	APC,RB1,ATM
GO:0030510	regulation of BMP signaling pathway	0.04300618317083747	0.04300618317083747	+1	NOTCH1,SMAD4,SMAD2
GO:0032091	negative regulation of protein binding	0.04300618317083747	0.04300618317083747	+1	AKT1,LRRK2,CDKN1A
GO:0045740	positive regulation of DNA replication	0.04335886763609856	0.04335886763609856	+1	EGFR,ATRX
GO:0048146	positive regulation of fibroblast proliferation	0.04335886763609856	0.04335886763609856	+1	PDGFRA,CDKN1A
GO:0051443	positive regulation of ubiquitin-protein transferase activity	0.04335886763609856	0.04335886763609856	+1	PTEN,FBXW7
GO:0031114	regulation of microtubule depolymerization	0.04335886763609856	0.04335886763609856	+1	APC,NAV3
GO:0071354	cellular response to interleukin-6	0.04335886763609856	0.04335886763609856	+1	CEBPA,SMAD4
GO:0001658	branching involved in ureteric bud morphogenesis	0.04335886763609856	0.04335886763609856	+1	SOX9,WT1
GO:0080111	DNA demethylation	0.04335886763609856	0.04335886763609856	+1	TET2,USP9X
GO:0045429	positive regulation of nitric oxide biosynthetic process	0.04335886763609856	0.04335886763609856	+1	AKT1,TLR4
GO:0042098	T cell proliferation	0.043873914195084206	0.043873914195084206	+1	CDKN2A,PIK3CG,TGFBR2,MAPK8IP1
GO:0001938	positive regulation of endothelial cell proliferation	0.0442275213214603	0.0442275213214603	+1	NRAS,AKT1,EGR3
GO:0043543	protein acylation	0.044988420093341565	0.044988420093341565	+1	BRCA1,EP300,SMAD4,BRCA2,SF3B1
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	0.04559886631908718	0.04559886631908718	+1	NFE2L2,AKT1,LRRK2
GO:0030218	erythrocyte differentiation	0.04559886631908718	0.04559886631908718	+1	KIT,ACVR1B,ACVR2A
GO:0001704	formation of primary germ layer	0.04559886631908718	0.04559886631908718	+1	SETD2,SOX17,SMAD2
GO:0070231	T cell apoptotic process	0.0457422407955121	0.0457422407955121	+1	TP53,AKT1
GO:0060416	response to growth hormone	0.0457422407955121	0.0457422407955121	+1	PIK3R1,AKT1
GO:0046686	response to cadmium ion	0.0457422407955121	0.0457422407955121	+1	EGFR,AKT1
GO:1904407	positive regulation of nitric oxide metabolic process	0.0457422407955121	0.0457422407955121	+1	AKT1,TLR4
GO:0045746	negative regulation of Notch signaling pathway	0.0457422407955121	0.0457422407955121	+1	FBXW7,AKT1
GO:1903955	positive regulation of protein targeting to mitochondrion	0.0457422407955121	0.0457422407955121	+1	FBXW7,BAP1
GO:0050999	regulation of nitric-oxide synthase activity	0.0457422407955121	0.0457422407955121	+1	EGFR,AKT1
GO:0048009	insulin-like growth factor receptor signaling pathway	0.0457422407955121	0.0457422407955121	+1	PIK3R1,AKT1
GO:0035521	monoubiquitinated histone deubiquitination	0.0457422407955121	0.0457422407955121	+1	BAP1,ASXL1
GO:0035522	monoubiquitinated histone H2A deubiquitination	0.0457422407955121	0.0457422407955121	+1	BAP1,ASXL1
GO:0031023	microtubule organizing center organization	0.04652136445784009	0.04652136445784009	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:0043535	regulation of blood vessel endothelial cell migration	0.0467101870414155	0.0467101870414155	+1	NF1,NOTCH1,AKT1
GO:1901222	regulation of NIK/NF-kappaB signaling	0.0467101870414155	0.0467101870414155	+1	EGFR,TLR4,EP300
GO:0050768	negative regulation of neurogenesis	0.0467101870414155	0.0467101870414155	+1	PTEN,NF1,NOTCH1
GO:0032286	central nervous system myelin maintenance	0.046736392256369545	0.046736392256369545	+1	PTEN
GO:0055118	negative regulation of cardiac muscle contraction	0.046736392256369545	0.046736392256369545	+1	PIK3CG
GO:1905857	positive regulation of pentose-phosphate shunt	0.046736392256369545	0.046736392256369545	+1	MTOR
GO:0032354	response to follicle-stimulating hormone	0.046736392256369545	0.046736392256369545	+1	NOTCH1
GO:1990428	miRNA transport	0.046736392256369545	0.046736392256369545	+1	TGFBR2
GO:0032497	detection of lipopolysaccharide	0.046736392256369545	0.046736392256369545	+1	TLR4
GO:0060693	regulation of branching involved in salivary gland morphogenesis	0.046736392256369545	0.046736392256369545	+1	HGF
GO:1905289	regulation of CAMKK-AMPK signaling cascade	0.046736392256369545	0.046736392256369545	+1	LRRK2
GO:0002331	pre-B cell allelic exclusion	0.046736392256369545	0.046736392256369545	+1	ATM
GO:1904761	negative regulation of myofibroblast differentiation	0.046736392256369545	0.046736392256369545	+1	RB1
GO:0002514	B cell tolerance induction	0.046736392256369545	0.046736392256369545	+1	TGFBR2
GO:0001942	hair follicle development	0.046736392256369545	0.046736392256369545	+1	SOX9,FGFR2
GO:1904760	regulation of myofibroblast differentiation	0.046736392256369545	0.046736392256369545	+1	RB1
GO:1904466	positive regulation of matrix metallopeptidase secretion	0.046736392256369545	0.046736392256369545	+1	TLR4
GO:0060601	lateral sprouting from an epithelium	0.046736392256369545	0.046736392256369545	+1	FGFR2
GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	0.046736392256369545	0.046736392256369545	+1	PTEN
GO:0070167	regulation of biomineral tissue development	0.046736392256369545	0.046736392256369545	+1	NOTCH1,SOX9,ACVR2A
GO:0031134	sister chromatid biorientation	0.046736392256369545	0.046736392256369545	+1	RB1
GO:0051599	response to hydrostatic pressure	0.046736392256369545	0.046736392256369545	+1	PIK3CA
GO:1903335	regulation of vacuolar transport	0.046736392256369545	0.046736392256369545	+1	LRRK2
GO:1903300	negative regulation of hexokinase activity	0.046736392256369545	0.046736392256369545	+1	FOXA2
GO:1905072	cardiac jelly development	0.046736392256369545	0.046736392256369545	+1	TBX3
GO:0043303	mast cell degranulation	0.046736392256369545	0.046736392256369545	+1	PIK3CG,KIT
GO:0032765	positive regulation of mast cell cytokine production	0.046736392256369545	0.046736392256369545	+1	KIT
GO:0032763	regulation of mast cell cytokine production	0.046736392256369545	0.046736392256369545	+1	KIT
GO:0061001	regulation of dendritic spine morphogenesis	0.046736392256369545	0.046736392256369545	+1	PTEN,LRRK2
GO:0060916	mesenchymal cell proliferation involved in lung development	0.046736392256369545	0.046736392256369545	+1	FGFR2
GO:2001205	negative regulation of osteoclast development	0.046736392256369545	0.046736392256369545	+1	FBXW7
GO:0036023	embryonic skeletal limb joint morphogenesis	0.046736392256369545	0.046736392256369545	+1	CTNNB1
GO:0036022	limb joint morphogenesis	0.046736392256369545	0.046736392256369545	+1	CTNNB1
GO:0036216	cellular response to stem cell factor stimulus	0.046736392256369545	0.046736392256369545	+1	KIT
GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose	0.046736392256369545	0.046736392256369545	+1	FOXA2
GO:2000974	negative regulation of pro-B cell differentiation	0.046736392256369545	0.046736392256369545	+1	NOTCH1
GO:2000825	positive regulation of androgen receptor activity	0.046736392256369545	0.046736392256369545	+1	TAF1
GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	0.046736392256369545	0.046736392256369545	+1	FOXA2
GO:0036369	transcription factor catabolic process	0.046736392256369545	0.046736392256369545	+1	TAF1
GO:0036446	myofibroblast differentiation	0.046736392256369545	0.046736392256369545	+1	RB1
GO:0035564	regulation of kidney size	0.046736392256369545	0.046736392256369545	+1	LRRK2
GO:2000639	negative regulation of SREBP signaling pathway	0.046736392256369545	0.046736392256369545	+1	FBXW7
GO:0061209	cell proliferation involved in mesonephros development	0.046736392256369545	0.046736392256369545	+1	GATA3
GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway	0.046736392256369545	0.046736392256369545	+1	PDGFRA
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	0.046736392256369545	0.046736392256369545	+1	PDGFRA
GO:0034183	negative regulation of maintenance of mitotic sister chromatid cohesion	0.046736392256369545	0.046736392256369545	+1	ATRX
GO:0034092	negative regulation of maintenance of sister chromatid cohesion	0.046736392256369545	0.046736392256369545	+1	ATRX
GO:0038109	Kit signaling pathway	0.046736392256369545	0.046736392256369545	+1	KIT
GO:0038162	erythropoietin-mediated signaling pathway	0.046736392256369545	0.046736392256369545	+1	KIT
GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	0.046736392256369545	0.046736392256369545	+1	BRCA1,NCOR1
GO:0033132	negative regulation of glucokinase activity	0.046736392256369545	0.046736392256369545	+1	FOXA2
GO:2000172	regulation of branching morphogenesis of a nerve	0.046736392256369545	0.046736392256369545	+1	LRRK2
GO:2000111	positive regulation of macrophage apoptotic process	0.046736392256369545	0.046736392256369545	+1	CDKN2A
GO:0032808	lacrimal gland development	0.046736392256369545	0.046736392256369545	+1	FGFR2
GO:0061325	cell proliferation involved in outflow tract morphogenesis	0.046736392256369545	0.046736392256369545	+1	CTNNB1
GO:0060742	epithelial cell differentiation involved in prostate gland development	0.046736392256369545	0.046736392256369545	+1	FGFR2
GO:0032776	DNA methylation on cytosine	0.046736392256369545	0.046736392256369545	+1	DNMT3A
GO:0032762	mast cell cytokine production	0.046736392256369545	0.046736392256369545	+1	KIT
GO:0030997	regulation of centriole-centriole cohesion	0.046736392256369545	0.046736392256369545	+1	CTNNB1
GO:0045448	mitotic cell cycle, embryonic	0.046736392256369545	0.046736392256369545	+1	CTNNB1
GO:0030950	establishment or maintenance of actin cytoskeleton polarity	0.046736392256369545	0.046736392256369545	+1	ARHGAP35
GO:0014041	regulation of neuron maturation	0.046736392256369545	0.046736392256369545	+1	LRRK2
GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	0.046736392256369545	0.046736392256369545	+1	CTNNB1
GO:0010750	positive regulation of nitric oxide mediated signal transduction	0.046736392256369545	0.046736392256369545	+1	EGFR
GO:0048861	leukemia inhibitory factor signaling pathway	0.046736392256369545	0.046736392256369545	+1	LIFR
GO:0010611	regulation of cardiac muscle hypertrophy	0.046736392256369545	0.046736392256369545	+1	NOTCH1,SMAD4
GO:0097681	double-strand break repair via alternative nonhomologous end joining	0.046736392256369545	0.046736392256369545	+1	POLQ
GO:0048865	stem cell fate commitment	0.046736392256369545	0.046736392256369545	+1	SOX9
GO:0097252	oligodendrocyte apoptotic process	0.046736392256369545	0.046736392256369545	+1	TP53
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	0.046736392256369545	0.046736392256369545	+1	NFE2L2
GO:0010390	histone monoubiquitination	0.046736392256369545	0.046736392256369545	+1	BRCA1,BRCA2
GO:0097155	fasciculation of sensory neuron axon	0.046736392256369545	0.046736392256369545	+1	EPHA3
GO:0097028	dendritic cell differentiation	0.046736392256369545	0.046736392256369545	+1	FLT3,TGFBR2
GO:0009794	regulation of mitotic cell cycle, embryonic	0.046736392256369545	0.046736392256369545	+1	CTNNB1
GO:0060374	mast cell differentiation	0.046736392256369545	0.046736392256369545	+1	KIT
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	0.046736392256369545	0.046736392256369545	+1	FGFR2
GO:0009415	response to water	0.046736392256369545	0.046736392256369545	+1	PIK3CA
GO:0051136	regulation of NK T cell differentiation	0.046736392256369545	0.046736392256369545	+1	TGFBR2
GO:0060214	endocardium formation	0.046736392256369545	0.046736392256369545	+1	SOX17
GO:0072717	cellular response to actinomycin D	0.046736392256369545	0.046736392256369545	+1	TP53
GO:0006261	DNA-templated DNA replication	0.046736392256369545	0.046736392256369545	+1	ATRX,BRCA1,BRCA2,ATR
GO:0072277	metanephric glomerular capillary formation	0.046736392256369545	0.046736392256369545	+1	PDGFRA
GO:0072276	metanephric glomerulus vasculature morphogenesis	0.046736392256369545	0.046736392256369545	+1	PDGFRA
GO:0072275	metanephric glomerulus morphogenesis	0.046736392256369545	0.046736392256369545	+1	PDGFRA
GO:0072262	metanephric glomerular mesangial cell proliferation involved in metanephros development	0.046736392256369545	0.046736392256369545	+1	WT1
GO:0072179	nephric duct formation	0.046736392256369545	0.046736392256369545	+1	GATA3
GO:0060056	mammary gland involution	0.046736392256369545	0.046736392256369545	+1	ELF3
GO:0072125	negative regulation of glomerular mesangial cell proliferation	0.046736392256369545	0.046736392256369545	+1	WT1
GO:0006298	mismatch repair	0.046736392256369545	0.046736392256369545	+1	SETD2,AXIN2
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	0.046736392256369545	0.046736392256369545	+1	RB1
GO:0071557	histone H3-K27 demethylation	0.046736392256369545	0.046736392256369545	+1	KDM6A
GO:0090116	C-5 methylation of cytosine	0.046736392256369545	0.046736392256369545	+1	DNMT3A
GO:0016046	detection of fungus	0.046736392256369545	0.046736392256369545	+1	TLR4
GO:0014034	neural crest cell fate commitment	0.046736392256369545	0.046736392256369545	+1	SOX9
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	0.046736392256369545	0.046736392256369545	+1	LRRK2
GO:0021551	central nervous system morphogenesis	0.046736392256369545	0.046736392256369545	+1	ERBB4
GO:0003273	cell migration involved in endocardial cushion formation	0.046736392256369545	0.046736392256369545	+1	NOTCH1
GO:0046533	negative regulation of photoreceptor cell differentiation	0.046736392256369545	0.046736392256369545	+1	SOX9
GO:0036215	response to stem cell factor	0.046736392256369545	0.046736392256369545	+1	KIT
GO:0046532	regulation of photoreceptor cell differentiation	0.046736392256369545	0.046736392256369545	+1	SOX9
GO:0046640	regulation of alpha-beta T cell proliferation	0.046736392256369545	0.046736392256369545	+1	TGFBR2,MAPK8IP1
GO:0016241	regulation of macroautophagy	0.046736392256369545	0.046736392256369545	+1	PIK3CA,AKT1,MTOR,LRRK2
GO:1902822	regulation of late endosome to lysosome transport	0.046736392256369545	0.046736392256369545	+1	LRRK2
GO:1902948	negative regulation of tau-protein kinase activity	0.046736392256369545	0.046736392256369545	+1	RB1
GO:0046016	positive regulation of transcription by glucose	0.046736392256369545	0.046736392256369545	+1	FOXA2
GO:0003192	mitral valve formation	0.046736392256369545	0.046736392256369545	+1	NOTCH1
GO:0045899	positive regulation of RNA polymerase II transcription preinitiation complex assembly	0.046736392256369545	0.046736392256369545	+1	TP53
GO:0045726	positive regulation of integrin biosynthetic process	0.046736392256369545	0.046736392256369545	+1	AR
GO:0046488	phosphatidylinositol metabolic process	0.046736392256369545	0.046736392256369545	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
GO:1902499	positive regulation of protein autoubiquitination	0.046736392256369545	0.046736392256369545	+1	LRRK2
GO:0043467	regulation of generation of precursor metabolites and energy	0.04676736113865765	0.04676736113865765	+1	TP53,AKT1,MTOR
GO:0034101	erythrocyte homeostasis	0.04676736113865765	0.04676736113865765	+1	KIT,ACVR1B,ACVR2A
GO:1902745	positive regulation of lamellipodium organization	0.048056445229230804	0.048056445229230804	+1	PIK3CA,PIK3R1
GO:0001953	negative regulation of cell-matrix adhesion	0.048056445229230804	0.048056445229230804	+1	PTEN,CDKN2A
GO:0014743	regulation of muscle hypertrophy	0.048056445229230804	0.048056445229230804	+1	NOTCH1,SMAD4
GO:0050982	detection of mechanical stimulus	0.048056445229230804	0.048056445229230804	+1	CTNNB1,KIT
GO:0002448	mast cell mediated immunity	0.048056445229230804	0.048056445229230804	+1	PIK3CG,KIT
GO:0002279	mast cell activation involved in immune response	0.048056445229230804	0.048056445229230804	+1	PIK3CG,KIT
GO:1905898	positive regulation of response to endoplasmic reticulum stress	0.048056445229230804	0.048056445229230804	+1	PIK3R1,NFE2L2
GO:0022404	molting cycle process	0.048056445229230804	0.048056445229230804	+1	SOX9,FGFR2
GO:0022405	hair cycle process	0.048056445229230804	0.048056445229230804	+1	SOX9,FGFR2
GO:0098815	modulation of excitatory postsynaptic potential	0.048056445229230804	0.048056445229230804	+1	PTEN,LRRK2
GO:0010833	telomere maintenance via telomere lengthening	0.048056445229230804	0.048056445229230804	+1	CTNNB1,ATM,ATR
GO:0046633	alpha-beta T cell proliferation	0.048056445229230804	0.048056445229230804	+1	TGFBR2,MAPK8IP1
GO:0030282	bone mineralization	0.04933824960995425	0.04933824960995425	+1	FGFR2,FGFR3,ACVR2A
GO:2001235	positive regulation of apoptotic signaling pathway	0.04933824960995425	0.04933824960995425	+1	TP53,PTEN,FBXW7
GO:0051092	positive regulation of NF-kappaB transcription factor activity	0.04933824960995425	0.04933824960995425	+1	NPM1,AR,TLR4,EP300
GO:0150115	cell-substrate junction organization	0.04933824960995425	0.04933824960995425	+1	PTEN,PIK3R1,EPHA3
REAC:R-HSA-2219528	PI3K/AKT Signaling in Cancer	8.16821731109996e-10	8.16821731109996e-10	+1	PIK3CA,PTEN,EGFR,PIK3R1,FLT3,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PTPN11
REAC:R-HSA-8939211	ESR-mediated signaling	4.462652665576713e-9	4.462652665576713e-9	+1	PIK3CA,EGFR,PIK3R1,GATA3,RUNX1,NRAS,AKT1,STAG2,CDKN1B,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	1.6902658412807908e-7	1.6902658412807908e-7	+1	TP53,KRAS,CDKN2A,NOTCH1,CTNNB1,RUNX1,EP300,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-9703648	Signaling by FLT3 ITD and TKD mutants	2.7124682612073483e-7	2.7124682612073483e-7	+1	PIK3CA,PIK3R1,FLT3,NRAS,CDKN1A,PTPN11
REAC:R-HSA-199418	Negative regulation of the PI3K/AKT network	2.7124682612073483e-7	2.7124682612073483e-7	+1	PIK3CA,PTEN,EGFR,PIK3R1,FLT3,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-8951936	RUNX3 regulates p14-ARF	3.14478502211678e-7	3.14478502211678e-7	+1	KRAS,RUNX1,EP300,CCND1,CBFB
REAC:R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	6.40535160081551e-7	6.40535160081551e-7	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-2990846	SUMOylation	8.758394299114972e-7	8.758394299114972e-7	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	9.880247142448272e-7	9.880247142448272e-7	+1	PIK3CA,EGFR,PIK3R1,FLT3,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-9607240	FLT3 Signaling	0.0000020146690259216347	0.0000020146690259216347	+1	PIK3CA,PIK3R1,FLT3,NRAS,AKT1,CDKN1B,PTPN11
REAC:R-HSA-6804757	Regulation of TP53 Degradation	0.0000020146690259216347	0.0000020146690259216347	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-5633007	Regulation of TP53 Activity	0.000002088500838626918	0.000002088500838626918	+1	TP53,CDKN2A,STK11,AKT1,ATM,MTOR,BRCA1,CHEK2,EP300,TAF1,PPP2R1A,ATR
REAC:R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.0000022820604150523947	0.0000022820604150523947	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-9682385	FLT3 signaling in disease	0.0000065778267196197875	0.0000065778267196197875	+1	PIK3CA,PIK3R1,FLT3,NRAS,CDKN1A,PTPN11
REAC:R-HSA-9018519	Estrogen-dependent gene expression	0.00000679506305434031	0.00000679506305434031	+1	GATA3,RUNX1,STAG2,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.00000679506305434031	0.00000679506305434031	+1	PIK3CA,EGFR,PIK3R1,FLT3,HGF,KIT,PDGFRA,PTPN11
REAC:R-HSA-9614085	FOXO-mediated transcription	0.000007443724039673243	0.000007443724039673243	+1	STK11,AKT1,CDKN1B,EP300,SMAD4,CDKN1A,SIN3A,SMAD2
REAC:R-HSA-69231	Cyclin D associated events in G1	0.000008269998372362338	0.000008269998372362338	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-69236	G1 Phase	0.000008269998372362338	0.000008269998372362338	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-8848021	Signaling by PTK6	0.000015854400569925694	0.000015854400569925694	+1	EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
REAC:R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	0.000015854400569925694	0.000015854400569925694	+1	EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
REAC:R-HSA-5654741	Signaling by FGFR3	0.000015854400569925694	0.000015854400569925694	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5654743	Signaling by FGFR4	0.000026211876551835107	0.000026211876551835107	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-9673770	Signaling by PDGFRA extracellular domain mutants	0.00004213129440545434	0.00004213129440545434	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
REAC:R-HSA-9673767	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	0.00004213129440545434	0.00004213129440545434	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
REAC:R-HSA-2470946	Cohesin Loading onto Chromatin	0.00004213129440545434	0.00004213129440545434	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-1500620	Meiosis	0.00004918198020463039	0.00004918198020463039	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-8878166	Transcriptional regulation by RUNX2	0.0000496193863187196	0.0000496193863187196	+1	RB1,RUNX1,AKT1,AR,SOX9,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-5654736	Signaling by FGFR1	0.0000496193863187196	0.0000496193863187196	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.000057656224180005036	0.000057656224180005036	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-186763	Downstream signal transduction	0.00009613263082119196	0.00009613263082119196	+1	PIK3CA,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.00011373908871852157	0.00011373908871852157	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-68884	Mitotic Telophase/Cytokinesis	0.00011373908871852157	0.00011373908871852157	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.00011373908871852157	0.00011373908871852157	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-9009391	Extra-nuclear estrogen signaling	0.00013477262850763438	0.00013477262850763438	+1	PIK3CA,EGFR,PIK3R1,NRAS,AKT1,CDKN1B,CCND1
REAC:R-HSA-9665348	Signaling by ERBB2 ECD mutants	0.00015227472505216494	0.00015227472505216494	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	0.00015920697809039343	0.00015920697809039343	+1	RUNX1,CBFB,LIFR
REAC:R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	0.00015920697809039343	0.00015920697809039343	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-8851907	MET activates PI3K/AKT signaling	0.00015920697809039343	0.00015920697809039343	+1	PIK3CA,PIK3R1,HGF
REAC:R-HSA-1221632	Meiotic synapsis	0.00017385140899013217	0.00017385140899013217	+1	STAG2,BRCA1,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-1502540	Signaling by Activin	0.00018279953886142107	0.00018279953886142107	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-1474165	Reproduction	0.0001831366449427665	0.0001831366449427665	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-210993	Tie2 Signaling	0.0002307122738063217	0.0002307122738063217	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-180292	GAB1 signalosome	0.0002307122738063217	0.0002307122738063217	+1	PIK3CA,EGFR,PIK3R1,PTPN11
REAC:R-HSA-9711123	Cellular response to chemical stress	0.0002463439531645946	0.0002463439531645946	+1	CDKN2A,NOTCH1,KEAP1,NFE2L2,IDH1,AKT1,EP300,SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.0002463439531645946	0.0002463439531645946	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	0.0002463439531645946	0.0002463439531645946	+1	RB1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-9659787	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	0.0002463439531645946	0.0002463439531645946	+1	RB1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-157118	Signaling by NOTCH	0.0002463439531645946	0.0002463439531645946	+1	TP53,EGFR,NOTCH1,RUNX1,AKT1,ELF3,EP300,CCND1,HIST1H2BD,TBL1XR1,NCOR1
REAC:R-HSA-8941855	RUNX3 regulates CDKN1A transcription	0.0002463439531645946	0.0002463439531645946	+1	TP53,SMAD4,CDKN1A
REAC:R-HSA-9669938	Signaling by KIT in disease	0.0002463439531645946	0.0002463439531645946	+1	PIK3CA,PIK3R1,NRAS,KIT
REAC:R-HSA-9617828	FOXO-mediated transcription of cell cycle genes	0.0002463439531645946	0.0002463439531645946	+1	CDKN1B,SMAD4,CDKN1A,SMAD2
REAC:R-HSA-5655332	Signaling by FGFR3 in disease	0.0002463439531645946	0.0002463439531645946	+1	PIK3CA,PIK3R1,NRAS,FGFR3
REAC:R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.0002463439531645946	0.0002463439531645946	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.0002463439531645946	0.0002463439531645946	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-9703465	Signaling by FLT3 fusion proteins	0.0002463439531645946	0.0002463439531645946	+1	PIK3CA,PIK3R1,NRAS,CDKN1A
REAC:R-HSA-9670439	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	0.0002463439531645946	0.0002463439531645946	+1	PIK3CA,PIK3R1,NRAS,KIT
REAC:R-HSA-8934593	Regulation of RUNX1 Expression and Activity	0.0002463439531645946	0.0002463439531645946	+1	RUNX1,CCND1,CBFB,PTPN11
REAC:R-HSA-8878171	Transcriptional regulation by RUNX1	0.0002618654361570949	0.0002618654361570949	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,CCND1,CBFB,SIN3A,HIST1H2BD,PTPN11,LIFR
REAC:R-HSA-9006936	Signaling by TGFB family members	0.0002732251535310763	0.0002732251535310763	+1	EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,NCOR1,SMAD2
REAC:R-HSA-2559583	Cellular Senescence	0.0002732251535310763	0.0002732251535310763	+1	TP53,CDKN2A,RB1,MAP2K4,ATM,CDKN1B,CDKN1A,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-9671555	Signaling by PDGFR in disease	0.0002956067823451477	0.0002956067823451477	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
REAC:R-HSA-5654708	Downstream signaling of activated FGFR3	0.0002956067823451477	0.0002956067823451477	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	0.00029952371259960394	0.00029952371259960394	+1	ARID1A,PBRM1,RUNX1,EP300,CBFB
REAC:R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.0003384813277717632	0.0003384813277717632	+1	TP53,ATM,BRCA1,ATR,CDK12,ERCC2
REAC:R-HSA-69242	S Phase	0.00035552373186771184	0.00035552373186771184	+1	RB1,AKT1,STAG2,CDKN1B,CCND1,CDKN1A,SMC1A,SMC3,RAD21
REAC:R-HSA-6804760	Regulation of TP53 Activity through Methylation	0.00035552373186771184	0.00035552373186771184	+1	TP53,ATM,CHEK2,EP300
REAC:R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.0003685743602402723	0.0003685743602402723	+1	EGFR,NPM1,KIT,EP300,CDKN1A
REAC:R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.0003685743602402723	0.0003685743602402723	+1	TP53,STK11,ATM,BRCA1,CHEK2,TAF1,ATR
REAC:R-HSA-9675126	Diseases of mitotic cell cycle	0.0003685743602402723	0.0003685743602402723	+1	RB1,CDKN1B,ATRX,CCND1,CDKN1A
REAC:R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.00039105878451071443	0.00039105878451071443	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-1433557	Signaling by SCF-KIT	0.00040391166250181894	0.00040391166250181894	+1	PIK3CA,PIK3R1,NRAS,KIT,PTPN11
REAC:R-HSA-5654738	Signaling by FGFR2	0.00040391166250181894	0.00040391166250181894	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-112399	IRS-mediated signalling	0.00040391166250181894	0.00040391166250181894	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-5693532	DNA Double-Strand Break Repair	0.00043393605062620874	0.00043393605062620874	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-166520	Signaling by NTRKs	0.0004619029780751869	0.0004619029780751869	+1	PIK3CA,PIK3R1,NRAS,BRAF,EP300,PPP2R1A,PTPN11,EGR3
REAC:R-HSA-69563	p53-Dependent G1 DNA Damage Response	0.0004622401831548426	0.0004622401831548426	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	0.0004622401831548426	0.0004622401831548426	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-9664565	Signaling by ERBB2 KD Mutants	0.0004699598316575459	0.0004699598316575459	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-9006115	Signaling by NTRK2 (TRKB)	0.0004699598316575459	0.0004699598316575459	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-69615	G1/S DNA Damage Checkpoints	0.0005318697337258262	0.0005318697337258262	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.0005320226115425592	0.0005320226115425592	+1	APC,CTNNB1,AKT1,SOX9,SOX17
REAC:R-HSA-5654716	Downstream signaling of activated FGFR4	0.0005380617363202268	0.0005380617363202268	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.0005380617363202268	0.0005380617363202268	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-1227990	Signaling by ERBB2 in Cancer	0.0005380617363202268	0.0005380617363202268	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-5654687	Downstream signaling of activated FGFR1	0.0005380617363202268	0.0005380617363202268	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-388841	Costimulation by the CD28 family	0.0005457716663272211	0.0005457716663272211	+1	PIK3CA,PIK3R1,AKT1,MTOR,PPP2R1A,PTPN11
REAC:R-HSA-2428928	IRS-related events triggered by IGF1R	0.0005542589349356733	0.0005542589349356733	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-2428924	IGF1R signaling cascade	0.0005542589349356733	0.0005542589349356733	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-9755511	KEAP1-NFE2L2 pathway	0.0005542589349356733	0.0005542589349356733	+1	CDKN2A,NOTCH1,KEAP1,NFE2L2,IDH1,AKT1,EP300
REAC:R-HSA-5689880	Ub-specific processing proteases	0.0005803985235532626	0.0005803985235532626	+1	TP53,PTEN,GATA3,KEAP1,AR,SMAD4,USP9X,HIST1H2BD,SMAD2,AXIN2
REAC:R-HSA-1181150	Signaling by NODAL	0.0005911377696787633	0.0005911377696787633	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-9006335	Signaling by Erythropoietin	0.0005911377696787633	0.0005911377696787633	+1	PIK3CA,PIK3R1,NRAS,PIK3CG
REAC:R-HSA-5654696	Downstream signaling of activated FGFR2	0.0005911377696787633	0.0005911377696787633	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.0005911377696787633	0.0005911377696787633	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-1643713	Signaling by EGFR in Cancer	0.0005911377696787633	0.0005911377696787633	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	0.0006331894406869551	0.0006331894406869551	+1	CDKN2A,STAG2,BRCA1,SMC1A,SMC3,RAD21
REAC:R-HSA-5655291	Signaling by FGFR4 in disease	0.0006331894406869551	0.0006331894406869551	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-74751	Insulin receptor signalling cascade	0.0006405657976382274	0.0006405657976382274	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	0.0006806999972583256	0.0006806999972583256	+1	EGFR,AKT1,CDKN1B,CCND1
REAC:R-HSA-1227986	Signaling by ERBB2	0.0007013654224072962	0.0007013654224072962	+1	PIK3CA,EGFR,PIK3R1,NRAS,AKT1
REAC:R-HSA-190236	Signaling by FGFR	0.0007114781838251714	0.0007114781838251714	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-9707616	Heme signaling	0.0007600261293006511	0.0007600261293006511	+1	NFE2L2,TLR4,EP300,TBL1XR1,NCOR1
REAC:R-HSA-201556	Signaling by ALK	0.0007722847278567187	0.0007722847278567187	+1	PIK3CA,PIK3R1,EP300,SIN3A
REAC:R-HSA-1912422	Pre-NOTCH Expression and Processing	0.0007826629945327774	0.0007826629945327774	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-453279	Mitotic G1 phase and G1/S transition	0.00078500390451209	0.00078500390451209	+1	CDKN2A,RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-212165	Epigenetic regulation of gene expression	0.00078500390451209	0.00078500390451209	+1	DNMT3A,TET2,EP300,SF3B1,SIN3A,HIST1H2BD,ERCC2,EZH2
REAC:R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.0008037959406434783	0.0008037959406434783	+1	TP53,PIK3R1,GATA3,AKT1,HGF,CCND1,CDKN1A
REAC:R-HSA-177929	Signaling by EGFR	0.0008037959406434783	0.0008037959406434783	+1	PIK3CA,EGFR,PIK3R1,NRAS,PTPN11
REAC:R-HSA-9702518	STAT5 activation downstream of FLT3 ITD mutants	0.0008095892829428289	0.0008095892829428289	+1	FLT3,CDKN1A,PTPN11
REAC:R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.0008221394079033182	0.0008221394079033182	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.0008516886846317415	0.0008516886846317415	+1	AKT1,CDKN1B,MTOR,CDKN1A
REAC:R-HSA-5693606	DNA Double Strand Break Response	0.000860957916988144	0.000860957916988144	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-187037	Signaling by NTRK1 (TRKA)	0.000860957916988144	0.000860957916988144	+1	PIK3CA,PIK3R1,NRAS,BRAF,EP300,PPP2R1A,EGR3
REAC:R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.000860957916988144	0.000860957916988144	+1	TP53,NPM1,CDKN1B,EP300,CDKN1A
REAC:R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.0009287395435937569	0.0009287395435937569	+1	EP300,SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.0009733762034051421	0.0009733762034051421	+1	TP53,RB1,ATM,CDKN1B,CDKN1A,HIST1H2BD
REAC:R-HSA-9675151	Disorders of Developmental Biology	0.0010201470051385705	0.0010201470051385705	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9697154	Disorders of Nervous System Development	0.0010201470051385705	0.0010201470051385705	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	0.0010201470051385705	0.0010201470051385705	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9005895	Pervasive developmental disorders	0.0010201470051385705	0.0010201470051385705	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.001230637407413253	0.001230637407413253	+1	SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-5619507	Activation of HOX genes during differentiation	0.0012434016227376216	0.0012434016227376216	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.0012434016227376216	0.0012434016227376216	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-1236394	Signaling by ERBB4	0.0012526141433864574	0.0012526141433864574	+1	PIK3CA,EGFR,PIK3R1,NRAS,NCOR1
REAC:R-HSA-186797	Signaling by PDGF	0.0012526141433864574	0.0012526141433864574	+1	PIK3CA,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.0012960149286457307	0.0012960149286457307	+1	PIK3CA,PIK3R1,PIK3CG
REAC:R-HSA-8941326	RUNX2 regulates bone development	0.0013479355534724254	0.0013479355534724254	+1	RB1,AR,SMAD4,CBFB
REAC:R-HSA-1226099	Signaling by FGFR in disease	0.0014501983653058604	0.0014501983653058604	+1	PIK3CA,PIK3R1,NRAS,FGFR2,FGFR3
REAC:R-HSA-389356	CD28 co-stimulation	0.0015112239309745877	0.0015112239309745877	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-9616222	Transcriptional regulation of granulopoiesis	0.0015809893969708192	0.0015809893969708192	+1	RUNX1,CEBPA,EP300,CDKN1A,CBFB,HIST1H2BD
REAC:R-HSA-1963642	PI3K events in ERBB2 signaling	0.0015976258985131656	0.0015976258985131656	+1	PIK3CA,EGFR,PIK3R1
REAC:R-HSA-5654710	PI-3K cascade:FGFR3	0.0015976258985131656	0.0015976258985131656	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.0016483226872077994	0.0016483226872077994	+1	EP300,SMAD4,USP9X,TGFBR2,NCOR1,SMAD2
REAC:R-HSA-9753512	Signaling by RAS GTPase mutants	0.0017494203388804216	0.0017494203388804216	+1	KRAS,NRAS
REAC:R-HSA-9753510	Signaling by RAS GAP mutants	0.0017494203388804216	0.0017494203388804216	+1	KRAS,NRAS
REAC:R-HSA-8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	0.0017494203388804216	0.0017494203388804216	+1	RUNX1,CBFB
REAC:R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	0.0017494203388804216	0.0017494203388804216	+1	SMAD4,SMAD2
REAC:R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	0.0017494203388804216	0.0017494203388804216	+1	SMAD4,SMAD2
REAC:R-HSA-3304347	Loss of Function of SMAD4 in Cancer	0.0017494203388804216	0.0017494203388804216	+1	SMAD4,SMAD2
REAC:R-HSA-9649913	RAS GTPase cycle mutants	0.0017494203388804216	0.0017494203388804216	+1	KRAS,NRAS
REAC:R-HSA-2559585	Oncogene Induced Senescence	0.001794855524449829	0.001794855524449829	+1	TP53,CDKN2A,RB1,CDKN2C
REAC:R-HSA-1295596	Spry regulation of FGF signaling	0.0018634156173852297	0.0018634156173852297	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-198323	AKT phosphorylates targets in the cytosol	0.0018634156173852297	0.0018634156173852297	+1	AKT1,CDKN1B,CDKN1A
REAC:R-HSA-9034015	Signaling by NTRK3 (TRKC)	0.0018634156173852297	0.0018634156173852297	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.0018634156173852297	0.0018634156173852297	+1	TP53,CDKN1B,CDKN1A
REAC:R-HSA-69473	G2/M DNA damage checkpoint	0.0019168428979937932	0.0019168428979937932	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.0019168428979937932	0.0019168428979937932	+1	PIK3CA,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-9709570	Impaired BRCA2 binding to RAD51	0.0021573477300153585	0.0021573477300153585	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-114604	GPVI-mediated activation cascade	0.0021573477300153585	0.0021573477300153585	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
REAC:R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	0.0021711842017793255	0.0021711842017793255	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5654689	PI-3K cascade:FGFR1	0.0021711842017793255	0.0021711842017793255	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	0.0021711842017793255	0.0021711842017793255	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	0.0021711842017793255	0.0021711842017793255	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5339716	Signaling by GSK3beta mutants	0.0021711842017793255	0.0021711842017793255	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	0.0021711842017793255	0.0021711842017793255	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-4839743	Signaling by CTNNB1 phospho-site mutants	0.0021711842017793255	0.0021711842017793255	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	0.0022770019809173155	0.0022770019809173155	+1	RB1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-109704	PI3K Cascade	0.0022770019809173155	0.0022770019809173155	+1	PIK3CA,PIK3R1,FLT3,PTPN11
REAC:R-HSA-5655253	Signaling by FGFR2 in disease	0.0025198869795241383	0.0025198869795241383	+1	PIK3CA,PIK3R1,NRAS,FGFR2
REAC:R-HSA-201681	TCF dependent signaling in response to WNT	0.0025870793601669773	0.0025870793601669773	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
REAC:R-HSA-3656532	TGFBR1 KD Mutants in Cancer	0.002849999499829931	0.002849999499829931	+1	TGFBR2,SMAD2
REAC:R-HSA-69560	Transcriptional activation of p53 responsive genes  	0.002849999499829931	0.002849999499829931	+1	TP53,CDKN1A
REAC:R-HSA-194138	Signaling by VEGF	0.002849999499829931	0.002849999499829931	+1	PIK3CA,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-69895	Transcriptional  activation of  cell cycle inhibitor p21 	0.002849999499829931	0.002849999499829931	+1	TP53,CDKN1A
REAC:R-HSA-8853884	Transcriptional Regulation by VENTX	0.002849999499829931	0.002849999499829931	+1	TP53,CDKN2A,CTNNB1,CCND1
REAC:R-HSA-9682706	Replication of the SARS-CoV-1 genome	0.002849999499829931	0.002849999499829931	+1	VHL,RB1
REAC:R-HSA-196299	Beta-catenin phosphorylation cascade	0.002849999499829931	0.002849999499829931	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-9694686	Replication of the SARS-CoV-2 genome	0.002849999499829931	0.002849999499829931	+1	VHL,RB1
REAC:R-HSA-9679514	SARS-CoV-1 Genome Replication and Transcription	0.002849999499829931	0.002849999499829931	+1	VHL,RB1
REAC:R-HSA-9758941	Gastrulation	0.002849999499829931	0.002849999499829931	+1	CTNNB1,SMAD4,SMAD2
REAC:R-HSA-5654720	PI-3K cascade:FGFR4	0.002849999499829931	0.002849999499829931	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-9694682	SARS-CoV-2 Genome Replication and Transcription	0.002849999499829931	0.002849999499829931	+1	VHL,RB1
REAC:R-HSA-9754189	Germ layer formation at gastrulation	0.002849999499829931	0.002849999499829931	+1	CTNNB1,SMAD4,SMAD2
REAC:R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.002849999499829931	0.002849999499829931	+1	TGFBR2,SMAD2
REAC:R-HSA-8865999	MET activates PTPN11	0.002849999499829931	0.002849999499829931	+1	HGF,PTPN11
REAC:R-HSA-186712	Regulation of beta-cell development	0.002849999499829931	0.002849999499829931	+1	NOTCH1,AKT1,EP300,FOXA2
REAC:R-HSA-74752	Signaling by Insulin receptor	0.002885218525651244	0.002885218525651244	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.0030591367057050977	0.0030591367057050977	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-9701190	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	0.0033156730548414	0.0033156730548414	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-5654695	PI-3K cascade:FGFR2	0.0033156730548414	0.0033156730548414	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-9675136	Diseases of DNA Double-Strand Break Repair	0.0033156730548414	0.0033156730548414	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.003960602775147837	0.003960602775147837	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-6806834	Signaling by MET	0.004340462970024345	0.004340462970024345	+1	PIK3CA,PIK3R1,NRAS,HGF,PTPN11
REAC:R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.004413494376739577	0.004413494376739577	+1	CTNNB1,EP300
REAC:R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	0.004413494376739577	0.004413494376739577	+1	TGFBR2,SMAD2
REAC:R-HSA-389513	CTLA4 inhibitory signaling	0.004413494376739577	0.004413494376739577	+1	AKT1,PPP2R1A,PTPN11
REAC:R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	0.004413494376739577	0.004413494376739577	+1	RUNX1,CBFB
REAC:R-HSA-9759194	Nuclear events mediated by NFE2L2	0.004769303313842411	0.004769303313842411	+1	CDKN2A,NOTCH1,NFE2L2,IDH1,EP300
REAC:R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.004953303557658105	0.004953303557658105	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-69202	Cyclin E associated events during G1/S transition 	0.005919377075795278	0.005919377075795278	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-8857538	PTK6 promotes HIF1A stabilization	0.006143328166909798	0.006143328166909798	+1	EGFR,LRRK2
REAC:R-HSA-8849470	PTK6 Regulates Cell Cycle	0.006143328166909798	0.006143328166909798	+1	CDKN1B,CCND1
REAC:R-HSA-6802953	RAS signaling downstream of NF1 loss-of-function variants	0.006143328166909798	0.006143328166909798	+1	NF1,NRAS
REAC:R-HSA-2559580	Oxidative Stress Induced Senescence	0.006143328166909798	0.006143328166909798	+1	TP53,CDKN2A,MAP2K4,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-8931987	RUNX1 regulates estrogen receptor mediated transcription	0.006143328166909798	0.006143328166909798	+1	RUNX1,CBFB
REAC:R-HSA-8939245	RUNX1 regulates transcription of genes involved in BCR signaling	0.006143328166909798	0.006143328166909798	+1	RUNX1,CBFB
REAC:R-HSA-8939256	RUNX1 regulates transcription of genes involved in WNT signaling	0.006143328166909798	0.006143328166909798	+1	RUNX1,CBFB
REAC:R-HSA-8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	0.006143328166909798	0.006143328166909798	+1	RUNX1,CBFB
REAC:R-HSA-9028335	Activated NTRK2 signals through PI3K	0.006143328166909798	0.006143328166909798	+1	PIK3CA,PIK3R1
REAC:R-HSA-9603381	Activated NTRK3 signals through PI3K	0.006143328166909798	0.006143328166909798	+1	PIK3CA,PIK3R1
REAC:R-HSA-9022537	Loss of MECP2 binding ability to the NCoR/SMRT complex	0.006143328166909798	0.006143328166909798	+1	TBL1XR1,NCOR1
REAC:R-HSA-9645135	STAT5 Activation	0.006143328166909798	0.006143328166909798	+1	FLT3,PTPN11
REAC:R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.006189256584558282	0.006189256584558282	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-5654732	Negative regulation of FGFR3 signaling	0.006189256584558282	0.006189256584558282	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.006189256584558282	0.006189256584558282	+1	RB1,AR,CBFB
REAC:R-HSA-9675135	Diseases of DNA repair	0.0062868651350237	0.0062868651350237	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-9709603	Impaired BRCA2 binding to PALB2	0.006962695678432176	0.006962695678432176	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.00721731960792517	0.00721731960792517	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-109581	Apoptosis	0.007535990569322165	0.007535990569322165	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,AKT1,TLR4
REAC:R-HSA-9701193	Defective homologous recombination repair (HRR) due to PALB2 loss of function	0.007564505441769237	0.007564505441769237	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	0.007564505441769237	0.007564505441769237	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-9701192	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	0.007564505441769237	0.007564505441769237	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-2424491	DAP12 signaling	0.007564505441769237	0.007564505441769237	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-69206	G1/S Transition	0.007564505441769237	0.007564505441769237	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A
REAC:R-HSA-9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	0.007564505441769237	0.007564505441769237	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-2179392	EGFR Transactivation by Gastrin	0.007986977524720312	0.007986977524720312	+1	EGFR,NRAS
REAC:R-HSA-8941332	RUNX2 regulates genes involved in cell migration	0.007986977524720312	0.007986977524720312	+1	AKT1,CBFB
REAC:R-HSA-5654726	Negative regulation of FGFR1 signaling	0.008386385035326283	0.008386385035326283	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5218920	VEGFR2 mediated vascular permeability	0.009254267066613676	0.009254267066613676	+1	CTNNB1,AKT1,MTOR
REAC:R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.009254267066613676	0.009254267066613676	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-5654733	Negative regulation of FGFR4 signaling	0.009254267066613676	0.009254267066613676	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.009307819646703908	0.009307819646703908	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.009307819646703908	0.009307819646703908	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-69541	Stabilization of p53	0.009307819646703908	0.009307819646703908	+1	TP53,CDKN2A,ATM,CHEK2
REAC:R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.009307819646703908	0.009307819646703908	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.009307819646703908	0.009307819646703908	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.009307819646703908	0.009307819646703908	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-6807070	PTEN Regulation	0.009442609513772092	0.009442609513772092	+1	TP53,PTEN,AKT1,MTOR,MECOM,EZH2
REAC:R-HSA-5693538	Homology Directed Repair	0.009442609513772092	0.009442609513772092	+1	ATM,BRCA1,POLQ,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-350054	Notch-HLH transcription pathway	0.009818989684647285	0.009818989684647285	+1	NOTCH1,TBL1XR1,NCOR1
REAC:R-HSA-8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	0.009818989684647285	0.009818989684647285	+1	RUNX1,CBFB
REAC:R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.009818989684647285	0.009818989684647285	+1	CTNNB1,AXIN2
REAC:R-HSA-8851805	MET activates RAS signaling	0.009818989684647285	0.009818989684647285	+1	NRAS,HGF
REAC:R-HSA-8951430	RUNX3 regulates WNT signaling	0.009818989684647285	0.009818989684647285	+1	CTNNB1,CCND1
REAC:R-HSA-5654727	Negative regulation of FGFR2 signaling	0.009818989684647285	0.009818989684647285	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	0.010128204800278397	0.010128204800278397	+1	RUNX1,EP300,CBFB,SIN3A,HIST1H2BD
REAC:R-HSA-8943724	Regulation of PTEN gene transcription	0.010128204800278397	0.010128204800278397	+1	TP53,MTOR,MECOM,EZH2
REAC:R-HSA-8986944	Transcriptional Regulation by MECP2	0.010128204800278397	0.010128204800278397	+1	PTEN,SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.010858515275186534	0.010858515275186534	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-6804758	Regulation of TP53 Activity through Acetylation	0.011550940165270323	0.011550940165270323	+1	TP53,AKT1,EP300
REAC:R-HSA-9022692	Regulation of MECP2 expression and activity	0.011550940165270323	0.011550940165270323	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.011550940165270323	0.011550940165270323	+1	SMAD4,SIN3A,SMAD2
REAC:R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.011821248635829437	0.011821248635829437	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-9707564	Cytoprotection by HMOX1	0.01186911637754416	0.01186911637754416	+1	NFE2L2,SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-1250342	PI3K events in ERBB4 signaling	0.011911212951612769	0.011911212951612769	+1	PIK3CA,PIK3R1
REAC:R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	0.011911212951612769	0.011911212951612769	+1	NRAS,PTPN11
REAC:R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.011911212951612769	0.011911212951612769	+1	CTNNB1,CDH1
REAC:R-HSA-198203	PI3K/AKT activation	0.011911212951612769	0.011911212951612769	+1	PIK3CA,PIK3R1
REAC:R-HSA-6811555	PI5P Regulates TP53 Acetylation	0.011911212951612769	0.011911212951612769	+1	TP53,EP300
REAC:R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.012024757999586827	0.012024757999586827	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.012289004661239635	0.012289004661239635	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.01245104778435657	0.01245104778435657	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-9645723	Diseases of programmed cell death	0.012932498848247534	0.012932498848247534	+1	TP53,CDKN2A,DNMT3A,HIST1H2BD,EZH2
REAC:R-HSA-5655302	Signaling by FGFR1 in disease	0.013320671602866235	0.013320671602866235	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.013932575588795014	0.013932575588795014	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-2172127	DAP12 interactions	0.01420229626688025	0.01420229626688025	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-5673000	RAF activation	0.01420229626688025	0.01420229626688025	+1	NRAS,BRAF,PPP2R1A
REAC:R-HSA-9701898	STAT3 nuclear events downstream of ALK signaling	0.01420229626688025	0.01420229626688025	+1	EP300,SIN3A
REAC:R-HSA-8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	0.01420229626688025	0.01420229626688025	+1	RUNX1,CBFB
REAC:R-HSA-166166	MyD88-independent TLR4 cascade 	0.01420229626688025	0.01420229626688025	+1	TP53,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling 	0.01420229626688025	0.01420229626688025	+1	TP53,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-5357801	Programmed Cell Death	0.014384783868055914	0.014384783868055914	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,AKT1,TLR4
REAC:R-HSA-4791275	Signaling by WNT in cancer	0.015301382852091299	0.015301382852091299	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.015301382852091299	0.015301382852091299	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.015377517173325066	0.015377517173325066	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-5693537	Resolution of D-Loop Structures	0.016503815431813392	0.016503815431813392	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.016609277942317313	0.016609277942317313	+1	CDKN2A,CDKN1B,CDKN1A,HIST1H2BD,CDKN2C
REAC:R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.016609277942317313	0.016609277942317313	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-351906	Apoptotic cleavage of cell adhesion  proteins	0.016609277942317313	0.016609277942317313	+1	CTNNB1,CDH1
REAC:R-HSA-9690406	Transcriptional regulation of testis differentiation	0.016609277942317313	0.016609277942317313	+1	SOX9,WT1
REAC:R-HSA-179812	GRB2 events in EGFR signaling	0.016609277942317313	0.016609277942317313	+1	EGFR,NRAS
REAC:R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.016609277942317313	0.016609277942317313	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	0.017289726206463674	0.017289726206463674	+1	EP300,TBL1XR1,NCOR1
REAC:R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.017289726206463674	0.017289726206463674	+1	EP300,SMAD4,SMAD2
REAC:R-HSA-3214841	PKMTs methylate histone lysines	0.017289726206463674	0.017289726206463674	+1	SETD2,NSD1,MECOM,EZH2
REAC:R-HSA-1980143	Signaling by NOTCH1	0.018110024659856706	0.018110024659856706	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.018142147474806074	0.018142147474806074	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.018142147474806074	0.018142147474806074	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.018379777566900592	0.018379777566900592	+1	ATM,BRCA1,ATR
REAC:R-HSA-111465	Apoptotic cleavage of cellular proteins	0.018379777566900592	0.018379777566900592	+1	APC,CTNNB1,CDH1
REAC:R-HSA-168898	Toll-like Receptor Cascades	0.018816110425187355	0.018816110425187355	+1	TP53,MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-1433617	Regulation of signaling by NODAL	0.018901718187432658	0.018901718187432658	+1	ACVR1B,ACVR2A
REAC:R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	0.018901718187432658	0.018901718187432658	+1	POLQ,BRCA2
REAC:R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.018901718187432658	0.018901718187432658	+1	TP53,ATM
REAC:R-HSA-180336	SHC1 events in EGFR signaling	0.018901718187432658	0.018901718187432658	+1	EGFR,NRAS
REAC:R-HSA-8853659	RET signaling	0.019436793372603404	0.019436793372603404	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-69481	G2/M Checkpoints	0.019554083954187316	0.019554083954187316	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-5689896	Ovarian tumor domain proteases	0.02077506039357511	0.02077506039357511	+1	TP53,PTEN,APC
REAC:R-HSA-1963640	GRB2 events in ERBB2 signaling	0.021779687538148015	0.021779687538148015	+1	EGFR,NRAS
REAC:R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	0.021779687538148015	0.021779687538148015	+1	ARHGAP35,NRAS
REAC:R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.021779687538148015	0.021779687538148015	+1	RB1,PPP2R1A
REAC:R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.022961189095055554	0.022961189095055554	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
REAC:R-HSA-165159	MTOR signalling	0.02337437598190775	0.02337437598190775	+1	STK11,AKT1,MTOR
REAC:R-HSA-3899300	SUMOylation of transcription cofactors	0.02337437598190775	0.02337437598190775	+1	NPM1,EP300,SIN3A
REAC:R-HSA-3214858	RMTs methylate histone arginines	0.023552692559504124	0.023552692559504124	+1	ARID1A,PBRM1,DNMT3A,CCND1
REAC:R-HSA-4839748	Signaling by AMER1 mutants	0.02417511977528384	0.02417511977528384	+1	APC,PPP2R1A
REAC:R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.02417511977528384	0.02417511977528384	+1	APC,PPP2R1A
REAC:R-HSA-5654706	FRS-mediated FGFR3 signaling	0.02417511977528384	0.02417511977528384	+1	NRAS,PTPN11
REAC:R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.02417511977528384	0.02417511977528384	+1	TP53,AKT1
REAC:R-HSA-4839744	Signaling by APC mutants	0.02417511977528384	0.02417511977528384	+1	APC,PPP2R1A
REAC:R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.02417511977528384	0.02417511977528384	+1	APC,PPP2R1A
REAC:R-HSA-5675221	Negative regulation of MAPK pathway	0.02417511977528384	0.02417511977528384	+1	NRAS,BRAF,PPP2R1A
REAC:R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.02417511977528384	0.02417511977528384	+1	APC,PPP2R1A
REAC:R-HSA-4839735	Signaling by AXIN mutants	0.02417511977528384	0.02417511977528384	+1	APC,PPP2R1A
REAC:R-HSA-8941856	RUNX3 regulates NOTCH signaling	0.02417511977528384	0.02417511977528384	+1	NOTCH1,EP300
REAC:R-HSA-9649948	Signaling downstream of RAS mutants	0.024817685457610785	0.024817685457610785	+1	KRAS,NRAS,BRAF
REAC:R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.024817685457610785	0.024817685457610785	+1	KRAS,NRAS,BRAF
REAC:R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	0.024817685457610785	0.024817685457610785	+1	EP300,TBL1XR1,NCOR1
REAC:R-HSA-1500931	Cell-Cell communication	0.024817685457610785	0.024817685457610785	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,PTPN11
REAC:R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.024817685457610785	0.024817685457610785	+1	KRAS,NRAS,BRAF
REAC:R-HSA-1483255	PI Metabolism	0.024817685457610785	0.024817685457610785	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-6802957	Oncogenic MAPK signaling	0.024817685457610785	0.024817685457610785	+1	KRAS,NF1,NRAS,BRAF
REAC:R-HSA-6802949	Signaling by RAS mutants	0.024817685457610785	0.024817685457610785	+1	KRAS,NRAS,BRAF
REAC:R-HSA-5628897	TP53 Regulates Metabolic Genes	0.024817685457610785	0.024817685457610785	+1	TP53,PTEN,AKT1,MTOR
REAC:R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.024817685457610785	0.024817685457610785	+1	CEBPA,EP300,TBL1XR1,NCOR1
REAC:R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.024817685457610785	0.024817685457610785	+1	EGFR,KIT
REAC:R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.024817685457610785	0.024817685457610785	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.024866220806936266	0.024866220806936266	+1	ATM,BRCA1,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-9614657	FOXO-mediated transcription of cell death genes	0.026113039415426878	0.026113039415426878	+1	STK11,EP300
REAC:R-HSA-5654693	FRS-mediated FGFR1 signaling	0.026113039415426878	0.026113039415426878	+1	NRAS,PTPN11
REAC:R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.026113039415426878	0.026113039415426878	+1	EGFR,NRAS
REAC:R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.026113039415426878	0.026113039415426878	+1	TLR4,PTPN11
REAC:R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	0.026113039415426878	0.026113039415426878	+1	PIK3CA,PIK3R1
REAC:R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.026113039415426878	0.026113039415426878	+1	TP53,RB1
REAC:R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.026113039415426878	0.026113039415426878	+1	NOTCH1,EP300
REAC:R-HSA-3371556	Cellular response to heat stress	0.026384170596527368	0.026384170596527368	+1	ATM,MTOR,EP300,ATR
REAC:R-HSA-912446	Meiotic recombination	0.026384170596527368	0.026384170596527368	+1	ATM,BRCA1,BRCA2,HIST1H2BD
REAC:R-HSA-9609690	HCMV Early Events	0.02656314127300739	0.02656314127300739	+1	EGFR,HIST1H2BD,TBL1XR1,NCOR1,EZH2
REAC:R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.027135844749816368	0.027135844749816368	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-9012852	Signaling by NOTCH3	0.02866931503086912	0.02866931503086912	+1	EGFR,NOTCH1,EP300
REAC:R-HSA-432142	Platelet sensitization by LDL	0.028974464212556145	0.028974464212556145	+1	PPP2R1A,PTPN11
REAC:R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.030370571671592378	0.030370571671592378	+1	CTNNB1,EP300,HIST1H2BD,AXIN2
REAC:R-HSA-1250196	SHC1 events in ERBB2 signaling	0.0317673143718651	0.0317673143718651	+1	EGFR,NRAS
REAC:R-HSA-3232118	SUMOylation of transcription factors	0.0317673143718651	0.0317673143718651	+1	TP53,CDKN2A
REAC:R-HSA-5654712	FRS-mediated FGFR4 signaling	0.0317673143718651	0.0317673143718651	+1	NRAS,PTPN11
REAC:R-HSA-3214842	HDMs demethylate histones	0.0317673143718651	0.0317673143718651	+1	KDM6A,KDM5C,ARID5B
REAC:R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.0317673143718651	0.0317673143718651	+1	TP53,EP300
REAC:R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	0.0317673143718651	0.0317673143718651	+1	EGFR,NRAS
REAC:R-HSA-1368082	RORA activates gene expression	0.0317673143718651	0.0317673143718651	+1	EP300,TBL1XR1
REAC:R-HSA-75153	Apoptotic execution phase	0.032983727914507946	0.032983727914507946	+1	APC,CTNNB1,CDH1
REAC:R-HSA-8876384	Listeria monocytogenes entry into host cells	0.03486007031805235	0.03486007031805235	+1	CTNNB1,CDH1
REAC:R-HSA-5654700	FRS-mediated FGFR2 signaling	0.03486007031805235	0.03486007031805235	+1	NRAS,PTPN11
REAC:R-HSA-210745	Regulation of gene expression in beta cells	0.03486007031805235	0.03486007031805235	+1	AKT1,FOXA2
REAC:R-HSA-8978934	Metabolism of cofactors	0.03486007031805235	0.03486007031805235	+1	IDH1,AKT1
REAC:R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.03508227909356815	0.03508227909356815	+1	TP53,MAP3K1,MAP2K4,PPP2R1A
REAC:R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.03508227909356815	0.03508227909356815	+1	TP53,MAP3K1,MAP2K4,PPP2R1A
REAC:R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.03508227909356815	0.03508227909356815	+1	TP53,MAP3K1,MAP2K4,PPP2R1A
REAC:R-HSA-9700206	Signaling by ALK in cancer	0.03572723072900091	0.03572723072900091	+1	PIK3CA,PIK3R1,NPM1
REAC:R-HSA-9725370	Signaling by ALK fusions and activated point mutants	0.03572723072900091	0.03572723072900091	+1	PIK3CA,PIK3R1,NPM1
REAC:R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.03572723072900091	0.03572723072900091	+1	IDH2,TBL1XR1,NCOR1
REAC:R-HSA-5693607	Processing of DNA double-strand break ends	0.035980856314038856	0.035980856314038856	+1	ATM,BRCA1,ATR,HIST1H2BD
REAC:R-HSA-109606	Intrinsic Pathway for Apoptosis	0.037300404100035815	0.037300404100035815	+1	TP53,CDKN2A,AKT1
REAC:R-HSA-8941858	Regulation of RUNX3 expression and activity	0.037300404100035815	0.037300404100035815	+1	CDKN2A,EP300,CBFB
REAC:R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.03742365508269201	0.03742365508269201	+1	TP53,ATM
REAC:R-HSA-5621575	CD209 (DC-SIGN) signaling	0.03742365508269201	0.03742365508269201	+1	NRAS,EP300
REAC:R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	0.03742365508269201	0.03742365508269201	+1	NOTCH1,EP300
REAC:R-HSA-912631	Regulation of signaling by CBL	0.04091016575967785	0.04091016575967785	+1	PIK3CA,PIK3R1
REAC:R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.04091016575967785	0.04091016575967785	+1	TP53,NPM1
REAC:R-HSA-113510	E2F mediated regulation of DNA replication	0.042756571179204964	0.042756571179204964	+1	RB1,PPP2R1A
REAC:R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.042756571179204964	0.042756571179204964	+1	SMAD4,SMAD2
REAC:R-HSA-9609646	HCMV Infection	0.04497117366582014	0.04497117366582014	+1	EGFR,HIST1H2BD,TBL1XR1,NCOR1,EZH2
REAC:R-HSA-373753	Nephrin family interactions	0.04631596303698325	0.04631596303698325	+1	PIK3CA,PIK3R1
REAC:R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	0.04631596303698325	0.04631596303698325	+1	CDKN1B,CCND1,CDKN1A
REAC:R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.04826326999389789	0.04826326999389789	+1	EP300,PPP2R1A,EGR3
REAC:R-HSA-6783589	Interleukin-6 family signaling	0.04935524132807597	0.04935524132807597	+1	PTPN11,LIFR
REAC:R-HSA-9648002	RAS processing	0.04935524132807597	0.04935524132807597	+1	KRAS,NRAS
REAC:R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	0.04935524132807597	0.04935524132807597	+1	NOTCH1,EP300
REAC:R-HSA-3371571	HSF1-dependent transactivation	0.04935524132807597	0.04935524132807597	+1	MTOR,EP300
REAC:R-HSA-2173788	Downregulation of TGF-beta receptor signaling	0.04935524132807597	0.04935524132807597	+1	TGFBR2,SMAD2
REAC:R-HSA-9734009	Defective Intrinsic Pathway for Apoptosis	0.04935524132807597	0.04935524132807597	+1	TP53,CDKN2A
WP:WP4674	Head and neck squamous cell carcinoma	3.399868992931084e-25	3.399868992931084e-25	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,PIK3R1,CDKN2A,RB1,NOTCH1,CTNNB1,KEAP1,NFE2L2,NRAS,STK11,AKT1,AJUBA,PIK3CG,MTOR,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A
WP:WP2261	Glioblastoma signaling pathways	4.0577609883963766e-24	4.0577609883963766e-24	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NRAS,MAP2K4,AKT1,BRAF,PIK3CG,ATM,CDKN1B,BRCA1,PDGFRA,EP300,FGFR2,CCND1,BRCA2,CDKN1A,CDKN2C
WP:WP3651	Pathways affected in adenoid cystic carcinoma	5.405762643257573e-19	5.405762643257573e-19	+1	TP53,PIK3CA,PTEN,ARID1A,NOTCH1,FBXW7,CEBPA,KDM6A,AKT1,ATM,ARID5B,ATRX,BRCA1,CHEK2,SETD2,EP300,SMC1A,NSD1,NCOR1
WP:WP4155	Endometrial cancer	2.601834750949085e-16	2.601834750949085e-16	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,PIK3R1,CTNNB1,CDH1,NRAS,AKT1,BRAF,FGFR2,CCND1,FGFR3,CDKN1A,AXIN2
WP:WP4262	Breast cancer pathway	3.5364159001979764e-15	3.5364159001979764e-15	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,PIK3R1,RB1,NOTCH1,CTNNB1,NRAS,AKT1,BRAF,ATM,MTOR,BRCA1,KIT,CCND1,BRCA2,CDKN1A,ATR,AXIN2
WP:WP4685	Melanoma	2.0501596699816714e-14	2.0501596699816714e-14	+1	TP53,PIK3CA,PTEN,KRAS,NF1,PIK3R1,CDKN2A,RB1,CDH1,NRAS,AKT1,BRAF,ERBB4,KIT,CCND1,CDKN1A
WP:WP4263	Pancreatic adenocarcinoma pathway	1.392248144713195e-12	1.392248144713195e-12	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CDKN2A,RB1,AKT1,BRAF,MTOR,CCND1,SMAD4,BRCA2,TGFBR2,CDKN1A,SMAD2
WP:WP2263	Androgen receptor network in prostate cancer	2.384442185920085e-12	2.384442185920085e-12	+1	TP53,PIK3CA,PTEN,ARID1A,RB1,AKT1,AR,ATM,HGF,MTOR,BRCA1,FOXA1,CHEK2,CCND1,ATR,PTPN11,SMAD2
WP:WP710	DNA damage response (only ATM dependent)	2.384442185920085e-12	2.384442185920085e-12	+1	TP53,PIK3CA,PTEN,APC,KRAS,PIK3R1,CDKN2A,CTNNB1,MAP3K1,NRAS,AKT1,PIK3CG,ATM,CDKN1B,CCND1,SMAD4,CDKN1A
WP:WP2870	Extracellular vesicle-mediated signaling in recipient cells	2.5642417563611326e-12	2.5642417563611326e-12	+1	APC,KRAS,EGFR,CTNNB1,NRAS,AKT1,HGF,MTOR,SMAD4,TGFBR2,SMAD2
WP:WP2828	Bladder cancer	2.626582673788428e-12	2.626582673788428e-12	+1	TP53,KRAS,EGFR,PIK3R1,CDKN2A,RB1,CDH1,NRAS,BRAF,CCND1,FGFR3,CDKN1A
WP:WP4806	EGFR tyrosine kinase inhibitor resistance	6.810236290767009e-12	6.810236290767009e-12	+1	PIK3CA,PTEN,KRAS,EGFR,NF1,PIK3R1,NRAS,AKT1,BRAF,HGF,MTOR,PDGFRA,FGFR2,CCND1,FGFR3
WP:WP179	Cell cycle	7.517974934126832e-12	7.517974934126832e-12	+1	TP53,CDKN2A,RB1,STAG2,ATM,CDKN1B,CHEK2,EP300,CCND1,SMAD4,CDKN1A,ATR,SMC1A,SMC3,SMAD2,RAD21,CDKN2C
WP:WP138	Androgen receptor signaling pathway	2.422357143105224e-10	2.422357143105224e-10	+1	PTEN,EGFR,PIK3R1,RB1,CTNNB1,AKT1,AR,BRCA1,EP300,CCND1,SMAD4,CDKN1A,SIN3A,NCOR1
WP:WP673	ErbB signaling pathway	3.108888253238778e-10	3.108888253238778e-10	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,NRAS,MAP2K4,AKT1,BRAF,CDKN1B,ERBB4,MTOR,CCND1,CDKN1A
WP:WP1971	Integrated cancer pathway	5.616735210664859e-10	5.616735210664859e-10	+1	TP53,PTEN,RB1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CDKN1A,ATR,SMAD2
WP:WP5322	CKAP4 signaling pathway map	6.433266938243316e-10	6.433266938243316e-10	+1	TP53,PIK3CA,PTEN,EGFR,FBXW7,CTNNB1,CDH1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,SMAD4,TGFBR2
WP:WP3844	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities	2.4072612286739924e-9	2.4072612286739924e-9	+1	PIK3CA,PTEN,KRAS,PIK3R1,NRAS,AKT1,PIK3CG,CDKN1B,MTOR
WP:WP4255	Non-small cell lung cancer	2.8925845832413644e-9	2.8925845832413644e-9	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CDKN2A,RB1,NRAS,AKT1,BRAF,CCND1,CDKN1A
WP:WP4216	Chromosomal and microsatellite instability in colorectal cancer 	3.267742538830631e-9	3.267742538830631e-9	+1	TP53,APC,KRAS,CTNNB1,AKT1,BRAF,CCND1,SMAD4,TGFBR2,CDKN1A,SMAD2,AXIN2
WP:WP4659	Gastrin signaling pathway	4.909943506167988e-9	4.909943506167988e-9	+1	PIK3CA,KRAS,EGFR,PIK3R1,CDKN2A,CTNNB1,CDH1,AKT1,CDKN1B,MTOR,KIT,CCND1,CDKN1A,PTPN11
WP:WP5300	TROP2 regulatory signaling	9.339255342313674e-9	9.339255342313674e-9	+1	PTEN,EGFR,PIK3R1,CDKN2A,RB1,NOTCH1,CTNNB1,CDH1,CDKN1B,CCND1
WP:WP4666	Hepatitis B infection	2.0640343364594805e-8	2.0640343364594805e-8	+1	PIK3CA,KRAS,PIK3R1,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,TLR4,EP300,SMAD4,TGFBR2,CDKN1A,EGR3,SMAD2
WP:WP2857	Mesodermal commitment pathway	2.1778182814098993e-8	2.1778182814098993e-8	+1	GATA3,NFE2L2,TBX3,KDM6A,ARID5B,FOXA1,SETD2,CCND1,SMAD4,FOXA2,SOX17,PHF6,ACVR2A,SMAD2,AXIN2
WP:WP707	DNA damage response	2.2591417925474926e-8	2.2591417925474926e-8	+1	TP53,RB1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR,SMC1A
WP:WP3584	MECP2 and associated Rett syndrome	4.065173859492901e-8	4.065173859492901e-8	+1	PTEN,NF1,CTCF,AKT1,MTOR,TET2,TAF1,SIN3A,SMC3,NCOR1,EZH2
WP:WP3931	Embryonic stem cell pluripotency pathways	5.577529487498433e-8	5.577529487498433e-8	+1	PTEN,APC,EGFR,CTNNB1,AKT1,BRAF,MTOR,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11,LIFR
WP:WP2586	Aryl hydrocarbon receptor pathway	1.0340695402745666e-7	1.0340695402745666e-7	+1	KRAS,EGFR,NF1,RB1,NFE2L2,NRAS,CDKN1B,EP300,CDKN1A
WP:WP3981	miRNA regulation of prostate cancer signaling pathways	1.8047840871032025e-7	1.8047840871032025e-7	+1	TP53,PIK3CA,KRAS,CTNNB1,AR,CDKN1B,MTOR,CCND1,CDKN1A
WP:WP4018	Clear cell renal cell carcinoma pathways	1.991137379427883e-7	1.991137379427883e-7	+1	PTEN,VHL,PBRM1,EGFR,BAP1,AKT1,KDM5C,MTOR,SETD2,PDGFRA,EP300
WP:WP3611	Photodynamic therapy-induced AP-1 survival signaling	1.991137379427883e-7	1.991137379427883e-7	+1	TP53,EGFR,CDKN2A,RB1,NFE2L2,MAP2K4,PDGFRA,CCND1,CDKN1A
WP:WP4483	Relationship between inflammation, COX-2 and EGFR	3.068303888527467e-7	3.068303888527467e-7	+1	PIK3CA,KRAS,EGFR,NRAS,AKT1,BRAF,PIK3CG
WP:WP3959	DNA IR-double strand breaks and cellular response via ATM	4.4989903766299045e-7	4.4989903766299045e-7	+1	TP53,CDKN2A,ATM,BRCA1,CHEK2,BRCA2,ATR,SMC1A,SMC3
WP:WP4541	Hippo-Merlin signaling dysregulation	6.604305108768802e-7	6.604305108768802e-7	+1	KRAS,EGFR,CTNNB1,FLT3,CDH1,NRAS,AJUBA,KIT,PDGFRA,FGFR2,CCND1,FGFR3
WP:WP4205	MET in type 1 papillary renal cell carcinoma	6.903672339275345e-7	6.903672339275345e-7	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,BRAF,HGF,CDKN1A,PTPN11
WP:WP61	Notch signaling pathway	7.849550637680407e-7	7.849550637680407e-7	+1	PIK3R1,GATA3,NOTCH1,FBXW7,AKT1,EP300,CCND1,CDKN1A,NCOR1
WP:WP5118	SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome	0.00000177565123891795	0.00000177565123891795	+1	ATM,BRCA1,SMC1A,SMC3,RAD21
WP:WP3657	Hematopoietic stem cell gene regulation by GABP alpha/beta complex	0.00000177565123891795	0.00000177565123891795	+1	PTEN,DNMT3A,FLT3,ATM,EP300,SMAD4
WP:WP4239	Epithelial to mesenchymal transition in colorectal cancer	0.0000019772171325391477	0.0000019772171325391477	+1	TP53,PIK3CA,KRAS,PIK3R1,NOTCH1,CTNNB1,CDH1,MAP2K4,AKT1,SMAD4,TGFBR2,SMAD2,EZH2
WP:WP3680	Physico-chemical features and toxicity-associated pathways	0.0000019772171325391477	0.0000019772171325391477	+1	APC,EGFR,CTNNB1,MAP2K4,AKT1,PIK3CG,CDKN1B,ERBB4,CDKN1A
WP:WP3303	RAC1/PAK1/p38/MMP2 pathway	0.0000024684143874719614	0.0000024684143874719614	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CTNNB1,NRAS,AKT1,PTPN11
WP:WP4539	Synaptic signaling pathways associated with autism spectrum disorder	0.000002559949882083871	0.000002559949882083871	+1	PIK3CA,PTEN,KRAS,NF1,PIK3R1,NRAS,AKT1,MTOR
WP:WP4540	Hippo signaling regulation pathways	0.000005725629726008005	0.000005725629726008005	+1	EGFR,CTNNB1,FLT3,CDH1,MTOR,KIT,PDGFRA,FGFR2,FGFR3,SMAD2
WP:WP51	Regulation of actin cytoskeleton	0.000005725629726008005	0.000005725629726008005	+1	PIK3CA,APC,KRAS,EGFR,PIK3R1,ARHGAP35,NRAS,BRAF,PIK3CG,PDGFRA,FGFR2,FGFR3
WP:WP1530	miRNA regulation of DNA damage response	0.000005725629726008005	0.000005725629726008005	+1	TP53,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR,SMC1A
WP:WP4223	Ras signaling	0.0000071707795997661195	0.0000071707795997661195	+1	PIK3CA,KRAS,EGFR,NF1,PIK3R1,FLT3,NRAS,AKT1,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
WP:WP3658	Wnt/beta-catenin signaling pathway in leukemia	0.000007959766676907525	0.000007959766676907525	+1	APC,CTNNB1,FLT3,AKT1,CCND1,AXIN2
WP:WP366	TGF-beta signaling pathway	0.000010421608978090246	0.000010421608978090246	+1	TP53,PIK3R1,MAP2K4,AKT1,EP300,CCND1,SMAD4,TGFBR2,CDKN1A,SIN3A,SMAD2
WP:WP45	G1 to S cell cycle control	0.000015637107471692894	0.000015637107471692894	+1	TP53,CDKN2A,RB1,ATM,CDKN1B,CCND1,CDKN1A,CDKN2C
WP:WP2374	Oncostatin M signaling pathway	0.000017302434852931158	0.000017302434852931158	+1	TP53,KRAS,PIK3R1,AKT1,CDKN1B,MTOR,PTPN11,LIFR
WP:WP4566	Translation inhibitors in chronically activated PDGFRA cells	0.000017568565667915194	0.000017568565667915194	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PIK3CG,MTOR,EIF4A2
WP:WP1403	AMP-activated protein kinase signaling	0.000021073151221757084	0.000021073151221757084	+1	TP53,PIK3CA,PIK3R1,STK11,AKT1,PIK3CG,MTOR,CDKN1A
WP:WP4838	Regucalcin in proximal tubule epithelial kidney cells	0.000021523482363194313	0.000021523482363194313	+1	PIK3CA,AKT1,BRAF,MTOR,SMAD4,SMAD2
WP:WP3676	BDNF-TrkB signaling	0.00003112407382619536	0.00003112407382619536	+1	KRAS,NRAS,AKT1,BRAF,PIK3CG,MTOR
WP:WP382	MAPK signaling pathway	0.00003213727491052132	0.00003213727491052132	+1	TP53,KRAS,EGFR,NF1,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,LRRK2,FGFR2,FGFR3,TGFBR2,MAPK8IP1
WP:WP4658	Small cell lung cancer	0.000035462574088159654	0.000035462574088159654	+1	TP53,PIK3CA,PTEN,PIK3R1,RB1,AKT1,CDKN1B,CCND1,CDKN1A
WP:WP5117	Cohesin complex - Cornelia de Lange syndrome	0.00003551516728265503	0.00003551516728265503	+1	APC,STAG2,PPP2R1A,SMC1A,SMC3,RAD21
WP:WP3927	BMP signaling in eyelid development	0.000036374736303241164	0.000036374736303241164	+1	EGFR,NOTCH1,MAP3K1,FGFR2,SMAD4
WP:WP5144	NRP1-triggered signaling pathways in pancreatic cancer 	0.000045625657386810506	0.000045625657386810506	+1	EGFR,AKT1,CDKN1B,HGF,SMAD4,TGFBR2,SMAD2
WP:WP395	IL-4 signaling pathway	0.000045625657386810506	0.000045625657386810506	+1	PIK3CA,PIK3R1,GATA3,CEBPA,AKT1,EP300,PTPN11
WP:WP399	Wnt signaling pathway and pluripotency	0.000049806811572159	0.000049806811572159	+1	TP53,APC,CTNNB1,MAP2K4,LRRK2,EP300,CCND1,PPP2R1A,AXIN2
WP:WP3646	Hepatitis C and hepatocellular carcinoma	0.000056649011255557974	0.000056649011255557974	+1	TP53,AKT1,BRCA1,CCND1,SMAD4,CDKN1A,PTPN11
WP:WP4879	Overlap between signal transduction pathways contributing to LMNA laminopathies	0.00006290548970281178	0.00006290548970281178	+1	APC,RB1,NOTCH1,CTNNB1,CEBPA,CDKN1A,SMAD2
WP:WP2516	ATM signaling pathway	0.000085035147905295	0.000085035147905295	+1	TP53,ATM,BRCA1,CHEK2,CDKN1A,SMC1A
WP:WP5191	Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution	0.00008715997275838016	0.00008715997275838016	+1	PIK3CA,AKT1,PIK3CG,MTOR
WP:WP2853	Endoderm differentiation	0.00012296104284425594	0.00012296104284425594	+1	APC,NOTCH1,CTNNB1,FOXA1,SMAD4,FOXA2,SOX17,PHF6,SMAD2,EZH2
WP:WP5098	T-cell activation SARS-CoV-2	0.0001292981273002084	0.0001292981273002084	+1	TP53,PTEN,PIK3R1,CDKN2A,AKT1,MTOR,CCND1,CDKN1A
WP:WP2446	Retinoblastoma gene in cancer	0.00015036527538477685	0.00015036527538477685	+1	TP53,RB1,CDKN1B,CCND1,CDKN1A,SIN3A,SMC1A,SMC3
WP:WP2032	Thyroid stimulating hormone (TSH) signaling pathway	0.00015385047971664548	0.00015385047971664548	+1	PIK3CA,PIK3R1,RB1,AKT1,BRAF,CDKN1B,MTOR
WP:WP4787	Osteoblast differentiation and related diseases	0.00015473286745102386	0.00015473286745102386	+1	PIK3CA,PIK3R1,NOTCH1,CTNNB1,PIK3CG,SOX9,FGFR2,SMAD4,FGFR3
WP:WP3878	ATM signaling in development and disease 	0.00015473286745102386	0.00015473286745102386	+1	STK11,ATM,MTOR,CHEK2,ATR,SMC1A
WP:WP3969	H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity	0.00021125173871230744	0.00021125173871230744	+1	RB1,CTNNB1,CDH1,CCND1
WP:WP2572	Primary focal segmental glomerulosclerosis (FSGS)	0.0002514875752096751	0.0002514875752096751	+1	NOTCH1,CTNNB1,AKT1,CDKN1B,WT1,TLR4,CDKN1A
WP:WP4186	Somatroph axis (GH) and its relationship to dietary restriction and aging	0.0002514875752096751	0.0002514875752096751	+1	PTEN,AKT1,MTOR
WP:WP2253	Pilocytic astrocytoma	0.0002514875752096751	0.0002514875752096751	+1	NF1,BRAF,PTPN11
WP:WP363	Wnt signaling pathway	0.0003002548038654487	0.0003002548038654487	+1	APC,CTNNB1,AKT1,MTOR,CCND1,AXIN2
WP:WP2839	Hair follicle development: organogenesis - part 2 of 3	0.00031694141683065	0.00031694141683065	+1	CTNNB1,CDH1,PDGFRA,FGFR2,CCND1
WP:WP306	Focal adhesion	0.00032213638725608353	0.00032213638725608353	+1	PIK3CA,PTEN,EGFR,PIK3R1,CTNNB1,ARHGAP35,AKT1,BRAF,HGF,PDGFRA,CCND1
WP:WP3286	Copper homeostasis	0.00032213638725608353	0.00032213638725608353	+1	TP53,PIK3CA,PTEN,APC,AKT1,CCND1
WP:WP4872	MAP3K1 role in promoting and blocking gonadal determination	0.00032213638725608353	0.00032213638725608353	+1	CTNNB1,MAP3K1,SOX9,FGFR2
WP:WP3859	TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition	0.00032213638725608353	0.00032213638725608353	+1	CDH1,AKT1,SMAD4,SMAD2
WP:WP422	MAPK cascade	0.0003478382266354842	0.0003478382266354842	+1	KRAS,MAP3K1,NRAS,MAP2K4,BRAF
WP:WP1544	MicroRNAs in cardiomyocyte hypertrophy	0.00035328804119925077	0.00035328804119925077	+1	PIK3CA,PIK3R1,CTNNB1,MAP2K4,AKT1,PIK3CG,MTOR,FGFR2
WP:WP2813	Mammary gland development pathway - Embryonic development (Stage 1 of 4)	0.00039577945762029877	0.00039577945762029877	+1	CDH1,AKT1,ERBB4,CCND1
WP:WP4016	DNA IR-damage and cellular response via ATR	0.00047665442426903524	0.00047665442426903524	+1	TP53,ATM,BRCA1,CHEK2,BRCA2,ATR,SMC1A
WP:WP1742	TP53 network	0.0004850152326788212	0.0004850152326788212	+1	TP53,CDKN2A,ATM,CDKN1A
WP:WP3850	Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling	0.0005054085824033582	0.0005054085824033582	+1	PTEN,AKT1,PIK3CG,MTOR,SMAD2
WP:WP34	Ovarian infertility	0.0005718354301734102	0.0005718354301734102	+1	AKT1,ATM,CDKN1B,MTOR,NCOR1
WP:WP3585	Cytosine methylation	0.0005720608820845946	0.0005720608820845946	+1	IDH1,TET2,IDH2
WP:WP4191	Caloric restriction and aging	0.0005720608820845946	0.0005720608820845946	+1	TP53,AKT1,MTOR
WP:WP4871	Kisspeptin/kisspeptin receptor system in the ovary	0.0007158043459898762	0.0007158043459898762	+1	PIK3CA,KRAS,NRAS,AKT1,PIK3CG
WP:WP127	IL-5 signaling pathway	0.000800883478608621	0.000800883478608621	+1	KRAS,PIK3R1,AKT1,PIK3CG,PTPN11
WP:WP4549	Fragile X syndrome	0.0009160908114285147	0.0009160908114285147	+1	PTEN,KRAS,NF1,CDKN2A,AKT1,BRAF,MTOR,PTPN11
WP:WP4790	FGF23 signaling in hypophosphatemic rickets and related disorders	0.000975520762645359	0.000975520762645359	+1	FGFR2,CCND1,FGFR3,CDKN1A
WP:WP1539	Angiogenesis	0.001146784837634843	0.001146784837634843	+1	PIK3CA,AKT1,PDGFRA,FGFR2
WP:WP481	Insulin signaling	0.0012050689523820108	0.0012050689523820108	+1	PIK3CA,PTEN,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG,MTOR,PTPN11
WP:WP437	EGF/EGFR signaling pathway	0.001249703361671784	0.001249703361671784	+1	PTEN,KRAS,EGFR,PIK3R1,MAP3K1,AKT1,BRAF,MTOR,PTPN11
WP:WP4842	Mammalian disorder of sexual development	0.001298221187706887	0.001298221187706887	+1	CTNNB1,SOX9,WT1,FGFR2
WP:WP205	IL-7 signaling pathway	0.001298221187706887	0.001298221187706887	+1	PIK3R1,AKT1,CDKN1B,CCND1
WP:WP1591	Heart development	0.0015985080863161892	0.0015985080863161892	+1	NOTCH1,CTNNB1,SMAD4,FOXA2,PTPN11
WP:WP2064	Neural crest differentiation	0.001602144909816995	0.001602144909816995	+1	NOTCH1,CTNNB1,CDH1,SOX9,FGFR2,FGFR3,AXIN2
WP:WP5316	Primary ovarian insufficiency	0.0020690587415974396	0.0020690587415974396	+1	PTEN,AKT1,ATM,WT1,MTOR,BRCA1,KIT,BRCA2,TGFBR2
WP:WP2034	Leptin signaling pathway	0.0020690587415974396	0.0020690587415974396	+1	PTEN,PIK3R1,AKT1,MTOR,CCND1,PTPN11
WP:WP2037	Prolactin signaling pathway	0.0020690587415974396	0.0020690587415974396	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,MTOR,PTPN11
WP:WP3972	PDGFR-beta pathway	0.0022090891748852873	0.0022090891748852873	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4
WP:WP2406	Cardiac progenitor differentiation	0.0026515146867788298	0.0026515146867788298	+1	NOTCH1,KIT,PDGFRA,FOXA2,SOX17
WP:WP4204	Tumor suppressor activity of SMARCB1	0.00278944665688896	0.00278944665688896	+1	ARID1A,CDKN2A,RB1,EZH2
WP:WP3982	miRNA regulation of p53 pathway in prostate cancer	0.00278944665688896	0.00278944665688896	+1	TP53,PTEN,ATM,CHEK2
WP:WP5192	Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids	0.002885780193333632	0.002885780193333632	+1	PIK3CA,AKT1,MTOR
WP:WP4582	Cancer immunotherapy by CTLA4 blockade	0.002885780193333632	0.002885780193333632	+1	PIK3CA,PIK3R1,PTPN11
WP:WP560	TGF-beta receptor signaling	0.0029569415361788004	0.0029569415361788004	+1	CTNNB1,EP300,SMAD4,TGFBR2,SMAD2
WP:WP195	IL-1 signaling pathway	0.0029569415361788004	0.0029569415361788004	+1	PIK3R1,MAP3K1,MAP2K4,AKT1,PTPN11
WP:WP2795	Cardiac hypertrophic response	0.0029569415361788004	0.0029569415361788004	+1	MAP3K1,MAP2K4,AKT1,MTOR,FGFR2
WP:WP3995	Prion disease pathway	0.002993496114738633	0.002993496114738633	+1	CTCF,EP300,SMC3,RAD21
WP:WP2431	Spinal cord injury	0.0032485317398143767	0.0032485317398143767	+1	TP53,EGFR,RB1,SOX9,CDKN1B,TLR4,CCND1
WP:WP2817	Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)	0.003260080792804165	0.003260080792804165	+1	EGFR,CEBPA,ERBB4,CCND1
WP:WP4874	CAMKK2 pathway	0.003260080792804165	0.003260080792804165	+1	NFE2L2,MTOR,EP300,SMC1A
WP:WP244	Alpha 6 beta 4 signaling pathway	0.003260080792804165	0.003260080792804165	+1	PIK3R1,AKT1,MTOR,PTPN11
WP:WP3	Transcriptional activation by NRF2 in response to phytochemicals	0.0032817518878660093	0.0032817518878660093	+1	PIK3CA,KEAP1,NFE2L2
WP:WP4240	Regulation of sister chromatid separation at the metaphase-anaphase transition	0.0032817518878660093	0.0032817518878660093	+1	SMC1A,SMC3,RAD21
WP:WP313	Hepatocyte growth factor receptor signaling	0.0035399430562494325	0.0035399430562494325	+1	PIK3CA,PTEN,HGF,PTPN11
WP:WP4241	Type 2 papillary renal cell carcinoma	0.0035399430562494325	0.0035399430562494325	+1	VHL,SETD2,EP300,CDKN1A
WP:WP254	Apoptosis	0.003546689147272914	0.003546689147272914	+1	TP53,PIK3R1,CDKN2A,MAP3K1,MAP2K4,AKT1
WP:WP2840	Hair follicle development: cytodifferentiation - part 3 of 3	0.003546689147272914	0.003546689147272914	+1	EGFR,GATA3,NOTCH1,CTNNB1,SOX9,SMAD4
WP:WP5236	Markers of kidney cell lineage	0.0036395739147015273	0.0036395739147015273	+1	NOTCH1,CTNNB1,WT1,KIT,AXIN2
WP:WP304	Kit receptor signaling pathway	0.0036395739147015273	0.0036395739147015273	+1	PIK3R1,AKT1,KIT,EP300,PTPN11
WP:WP4816	TGF-beta receptor signaling in skeletal dysplasias	0.0036395739147015273	0.0036395739147015273	+1	CTNNB1,EP300,SMAD4,TGFBR2,SMAD2
WP:WP5053	Development of ureteric collection system	0.0038986335295874814	0.0038986335295874814	+1	GATA3,CTNNB1,WT1,FGFR2,CCND1
WP:WP5180	DYRK1A	0.004421234606965616	0.004421234606965616	+1	TP53,NOTCH1,CDKN1B,MTOR,CCND1
WP:WP3874	Canonical and non-canonical TGF-B signaling	0.004421234606965616	0.004421234606965616	+1	SMAD4,TGFBR2,SMAD2
WP:WP3678	Amplification and expansion of oncogenic pathways as metastatic traits	0.004421234606965616	0.004421234606965616	+1	VHL,NOTCH1,PIK3CG
WP:WP4331	Neovascularisation processes	0.0044929206478199445	0.0044929206478199445	+1	NOTCH1,AKT1,KIT,SMAD2
WP:WP4844	Influence of laminopathies on Wnt signaling	0.0044929206478199445	0.0044929206478199445	+1	APC,CTNNB1,CEBPA,CCND1
WP:WP4829	mBDNF and proBDNF regulation of GABA neurotransmission	0.004933934370089789	0.004933934370089789	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
WP:WP4301	Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells	0.00509451591159036	0.00509451591159036	+1	KRAS,NRAS,BRAF
WP:WP236	Adipogenesis	0.0053250752867954115	0.0053250752867954115	+1	GATA3,RB1,CTNNB1,CEBPA,CDKN1A,LIFR,NCOR1
WP:WP4564	Neural crest cell migration during development	0.0053250752867954115	0.0053250752867954115	+1	PIK3CA,AKT1,PIK3CG,EPHB6
WP:WP4258	lncRNA in canonical Wnt signaling and colorectal cancer	0.0056121490484951795	0.0056121490484951795	+1	APC,CTNNB1,CCND1,SOX17,AXIN2,EZH2
WP:WP3915	Angiopoietin-like protein 8 regulatory pathway	0.005693689406671112	0.005693689406671112	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG,MTOR
WP:WP3941	Oxidative damage response	0.005693689406671112	0.005693689406671112	+1	MAP3K1,MAP2K4,CDKN1B,CDKN1A
WP:WP2526	PDGF pathway	0.005693689406671112	0.005693689406671112	+1	PIK3R1,MAP3K1,MAP2K4,PTPN11
WP:WP1545	miRNAs involved in DNA damage response	0.00613493642418063	0.00613493642418063	+1	TP53,ATM,CDKN1B,CCND1,CDKN1A
WP:WP3998	Prader-Willi and Angelman syndrome	0.00613493642418063	0.00613493642418063	+1	TP53,CDKN2A,RB1,CCND1,CDKN2C
WP:WP3640	Imatinib and chronic myeloid leukemia	0.0065084230431677855	0.0065084230431677855	+1	CDKN1B,KIT,PDGFRA
WP:WP4206	Hereditary leiomyomatosis and renal cell carcinoma pathway	0.0065084230431677855	0.0065084230431677855	+1	TP53,KEAP1,NFE2L2
WP:WP4565	Neural crest cell migration in cancer	0.006602568358014849	0.006602568358014849	+1	PIK3CA,AKT1,PIK3CG,EPHB6
WP:WP75	Toll-like receptor signaling pathway	0.007063330767544603	0.007063330767544603	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PIK3CG,TLR4
WP:WP364	IL6 signaling pathway	0.007063330767544603	0.007063330767544603	+1	PIK3R1,MAP2K4,AKT1,PTPN11
WP:WP4300	Extracellular vesicles in the crosstalk of cardiac cells	0.007273894911932461	0.007273894911932461	+1	PTEN,EGFR,TLR4
WP:WP4141	PI3K/AKT/mTOR - vitamin D3 signaling	0.008233273442480135	0.008233273442480135	+1	PIK3CA,AKT1,MTOR
WP:WP2873	Aryl hydrocarbon receptor pathway	0.008233273442480135	0.008233273442480135	+1	EGFR,NFE2L2,CDKN1B,EP300
WP:WP2380	Brain-derived neurotrophic factor (BDNF) signaling pathway	0.008474265712077038	0.008474265712077038	+1	APC,PIK3R1,CTNNB1,MAP3K1,AKT1,MTOR,PTPN11
WP:WP4535	Envelope proteins and their potential roles in EDMD physiopathology	0.008658577632520871	0.008658577632520871	+1	KRAS,NRAS,SMAD4,SMAD2
WP:WP2038	Microtubule cytoskeleton regulation	0.008658577632520871	0.008658577632520871	+1	PIK3CA,PTEN,APC,AKT1
WP:WP712	Estrogen signaling pathway	0.008916485668868684	0.008916485668868684	+1	PIK3CA,AKT1,BRAF
WP:WP4357	NRF2-ARE regulation	0.008916485668868684	0.008916485668868684	+1	PIK3CA,KEAP1,NFE2L2
WP:WP4830	GDNF/RET signaling axis	0.008916485668868684	0.008916485668868684	+1	GATA3,CTNNB1,SOX17
WP:WP5044	Kynurenine pathway and links to cell senescence	0.008916485668868684	0.008916485668868684	+1	TP53,TLR4,CDKN1A
WP:WP2203	Thymic stromal lymphopoietin (TSLP) signaling pathway	0.009082099449271982	0.009082099449271982	+1	PIK3CA,AKT1,MTOR,PTPN11
WP:WP3953	mRNA, protein, and metabolite inducation pathway by cyclosporin A	0.009235315679736959	0.009235315679736959	+1	KEAP1,NFE2L2
WP:WP4312	Rett syndrome causing genes	0.00968878536846185	0.00968878536846185	+1	BRAF,SMC1A,TBL1XR1,NCOR1
WP:WP5074	Kallmann syndrome	0.009850053377345194	0.009850053377345194	+1	PIK3CA,AKT1,PTPN11
WP:WP5055	Burn wound healing	0.010138594665489912	0.010138594665489912	+1	TP53,AKT1,HGF,TLR4,FGFR2,FGFR3
WP:WP3668	Hypothesized pathways in pathogenesis of cardiovascular disease	0.010953931459649794	0.010953931459649794	+1	SMAD4,TGFBR2,SMAD2
WP:WP3300	Dual hijack model of Vif in HIV infection	0.01170950908254365	0.01170950908254365	+1	RUNX1,CBFB
WP:WP4904	LDLRAD4 and what we know about it	0.01170950908254365	0.01170950908254365	+1	TGFBR2,SMAD2
WP:WP5119	NIPBL role in DNA damage - Cornelia de Lange syndrome	0.01170950908254365	0.01170950908254365	+1	ATM,ATR
WP:WP4747	Netrin-UNC5B signaling pathway	0.012416925137542617	0.012416925137542617	+1	TP53,PIK3CA,AKT1,PTPN11
WP:WP4767	FGFR3 signaling in chondrocyte proliferation and terminal differentiation	0.01327033482833353	0.01327033482833353	+1	SOX9,FGFR3,CDKN1A
WP:WP585	Interferon type I signaling pathways	0.014049554495535355	0.014049554495535355	+1	PIK3R1,MAP3K1,MTOR,PTPN11
WP:WP2643	Nanoparticle-mediated activation of receptor signaling	0.014308304240174477	0.014308304240174477	+1	KRAS,EGFR,NRAS
WP:WP5200	Dravet syndrome	0.014308304240174477	0.014308304240174477	+1	PIK3CA,AKT1,MTOR
WP:WP5121	Sphingolipid metabolism in senescence	0.014308304240174477	0.014308304240174477	+1	RB1,MTOR,CDKN1A
WP:WP5036	Angiotensin II receptor type 1 pathway	0.014308304240174477	0.014308304240174477	+1	SMAD4,TGFBR2,PTPN11
WP:WP3929	Chemokine signaling pathway	0.015547589435937178	0.015547589435937178	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,BRAF,PIK3CG
WP:WP4336	ncRNAs involved in Wnt signaling in hepatocellular carcinoma	0.01579361772910606	0.01579361772910606	+1	APC,CTNNB1,CCND1,SOX17,EZH2
WP:WP4217	Ebola virus infection in host	0.017012341646209902	0.017012341646209902	+1	PIK3CA,EGFR,PIK3R1,AKT1,TLR4,EP300
WP:WP5102	Familial partial lipodystrophy	0.017012341646209902	0.017012341646209902	+1	PIK3CA,GATA3,CEBPA
WP:WP5050	TCA cycle in senescence	0.017192821403344306	0.017192821403344306	+1	TP53,BRAF
WP:WP2815	Mammary gland development pathway - Involution (Stage 4 of 4)	0.017192821403344306	0.017192821403344306	+1	TP53,CDH1
WP:WP231	TNF-alpha signaling pathway	0.01764414737610873	0.01764414737610873	+1	KRAS,MAP3K1,NRAS,MAP2K4,AKT1
WP:WP4746	Thyroid hormones production and peripheral downstream signaling effects	0.018353307516597587	0.018353307516597587	+1	TP53,PIK3CA,NOTCH1,CTNNB1,MTOR
WP:WP2363	Gastric cancer network 2	0.019738369104275157	0.019738369104275157	+1	TP53,EGFR,CTNNB1
WP:WP4149	White fat cell differentiation	0.019738369104275157	0.019738369104275157	+1	GATA3,CEBPA,MECOM
WP:WP4147	PTF1A related regulatory pathway	0.020071156610165987	0.020071156610165987	+1	NOTCH1,CTNNB1
WP:WP5049	Glycolysis in senescence	0.020071156610165987	0.020071156610165987	+1	TP53,RB1
WP:WP3672	lncRNA-mediated mechanisms of therapeutic resistance	0.020071156610165987	0.020071156610165987	+1	TP53,CDKN1A
WP:WP4481	Resistin as a regulator of inflammation	0.021036247849079114	0.021036247849079114	+1	PIK3CA,AKT1,PIK3CG
WP:WP23	B cell receptor signaling pathway	0.021036247849079114	0.021036247849079114	+1	PIK3R1,AKT1,BRAF,PIK3CG,PTPN11
WP:WP4630	Measles virus infection	0.021232954921358346	0.021232954921358346	+1	TP53,PIK3CA,PIK3R1,CDKN1B,TLR4,CCND1
WP:WP2290	RalA downstream regulated genes	0.023388768114286883	0.023388768114286883	+1	KRAS,NRAS
WP:WP2369	Histone modifications	0.023889022688786187	0.023889022688786187	+1	SETBP1,SETD2,NSD1,EZH2
WP:WP4211	Transcriptional cascade regulating adipogenesis	0.026719637143256567	0.026719637143256567	+1	GATA3,CEBPA
WP:WP186	Homologous recombination	0.026719637143256567	0.026719637143256567	+1	ATM,BRCA2
WP:WP4919	Neuroinflammation	0.026719637143256567	0.026719637143256567	+1	MTOR,TLR4
WP:WP4673	Male infertility	0.02743265553056813	0.02743265553056813	+1	NFE2L2,AR,ATM,EP300,BRCA2,ERCC2
WP:WP722	Serotonin HTR1 group and FOS pathway	0.02743265553056813	0.02743265553056813	+1	PIK3CA,MAP3K1,BRAF
WP:WP5130	Th17 cell differentiation pathway	0.02828532545709481	0.02828532545709481	+1	GATA3,RUNX1,MTOR,SMAD2
WP:WP4814	Somatic sex determination	0.03029954170627259	0.03029954170627259	+1	SOX9,WT1
WP:WP3937	Microglia pathogen phagocytosis pathway	0.033396060358149814	0.033396060358149814	+1	PIK3CA,PIK3R1,PIK3CG
WP:WP3594	Circadian rhythm genes	0.036396025893997645	0.036396025893997645	+1	TP53,PTEN,EP300,SIN3A,EGR3,NCOR1,EZH2
WP:WP49	IL-2 signaling pathway	0.0376998123202731	0.0376998123202731	+1	PIK3R1,AKT1,PTPN11
WP:WP4928	MAPK pathway in congenital thyroid cancer	0.03833147428688354	0.03833147428688354	+1	KRAS,BRAF
WP:WP2435	Quercetin and Nf-kB / AP-1 induced apoptosis	0.03833147428688354	0.03833147428688354	+1	KEAP1,NFE2L2
WP:WP5198	Inflammatory bowel disease signaling	0.039197915793723295	0.039197915793723295	+1	GATA3,TLR4,SMAD2
WP:WP4136	Fibrin complement receptor 3 signaling pathway	0.039197915793723295	0.039197915793723295	+1	PIK3CA,AKT1,TLR4
WP:WP314	Fas ligand pathway and stress induction of heat shock proteins	0.039197915793723295	0.039197915793723295	+1	RB1,MAP3K1,MAP2K4
WP:WP4538	Regulatory circuits of the STAT3 signaling pathway	0.04061776603010664	0.04061776603010664	+1	EGFR,MTOR,PDGFRA,LIFR
WP:WP2332	Interleukin-11 signaling pathway	0.04108581786480675	0.04108581786480675	+1	PIK3R1,AKT1,PTPN11
WP:WP4823	Genes controlling nephrogenesis	0.04108581786480675	0.04108581786480675	+1	CTNNB1,WT1,FGFR2
WP:WP3664	Regulation of Wnt / B-catenin signaling by small molecule compounds	0.041296848383633886	0.041296848383633886	+1	APC,CTNNB1
WP:WP3935	Leptin-insulin signaling overlap	0.041296848383633886	0.041296848383633886	+1	AKT1,PIK3CG
WP:WP3413	NOTCH1 regulation of endothelial cell calcification	0.041296848383633886	0.041296848383633886	+1	NOTCH1,FGFR3
WP:WP4946	DNA repair pathways, full network	0.041775979415695164	0.041775979415695164	+1	ATM,BRCA1,BRCA2,ATR,ERCC2
WP:WP5205	Clock-controlled autophagy in bone metabolism	0.042737881638516814	0.042737881638516814	+1	NOTCH1,AKT1,MTOR,SMAD4
WP:WP4533	Transcription co-factors SKI and SKIL protein partners	0.04523152744862273	0.04523152744862273	+1	NF1,SIN3A
WP:WP3879	4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression	0.04523152744862273	0.04523152744862273	+1	AKT1,MTOR
WP:WP2848	Pluripotent stem cell differentiation pathway	0.049795311602753606	0.049795311602753606	+1	NOTCH1,HGF,KIT