GO.ID	Description	p.Val	FDR	Phenotype	Genes
GO:0051171	regulation of nitrogen compound metabolic process	9.255029390066472e-27	9.255029390066472e-27	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0060255	regulation of macromolecule metabolic process	9.255029390066472e-27	9.255029390066472e-27	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,RPL22,STK11,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0031323	regulation of cellular metabolic process	9.255029390066472e-27	9.255029390066472e-27	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0080090	regulation of primary metabolic process	1.1006594357267935e-26	1.1006594357267935e-26	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0019222	regulation of metabolic process	1.1006594357267935e-26	1.1006594357267935e-26	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,RPL22,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0051173	positive regulation of nitrogen compound metabolic process	4.35815961872012e-26	4.35815961872012e-26	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,ERCC2,EZH2,PCBP1
GO:0010604	positive regulation of macromolecule metabolic process	3.8132597887361297e-25	3.8132597887361297e-25	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,ERCC2,EZH2,PCBP1
GO:0009893	positive regulation of metabolic process	2.2288311058563653e-24	2.2288311058563653e-24	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,ERCC2,EZH2,PCBP1
GO:0031325	positive regulation of cellular metabolic process	2.3436626320608965e-24	2.3436626320608965e-24	+1	TP53,PTEN,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,ERCC2,EZH2,PCBP1
GO:0048522	positive regulation of cellular process	2.6414079475282037e-23	2.6414079475282037e-23	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2,PCBP1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5.843200521981466e-23	5.843200521981466e-23	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0048523	negative regulation of cellular process	1.5807182594032776e-22	1.5807182594032776e-22	+1	TP53,PIK3CA,PTEN,APC,VHL,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,CDKN2C,EZH2
GO:0097659	nucleic acid-templated transcription	2.0462163404764657e-22	2.0462163404764657e-22	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:1903506	regulation of nucleic acid-templated transcription	2.176125537752541e-22	2.176125537752541e-22	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,EZH2,PCBP1
GO:2001141	regulation of RNA biosynthetic process	2.176125537752541e-22	2.176125537752541e-22	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,EZH2,PCBP1
GO:0032774	RNA biosynthetic process	2.176125537752541e-22	2.176125537752541e-22	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0048518	positive regulation of biological process	2.696402062019307e-22	2.696402062019307e-22	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,CBFB,ATR,SIN3A,VEZF1,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2,PCBP1
GO:0010468	regulation of gene expression	8.288953801497787e-22	8.288953801497787e-22	+1	TP53,PTEN,VHL,KRAS,ARID1A,NAV3,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,EZH2,PCBP1
GO:0051252	regulation of RNA metabolic process	8.288953801497787e-22	8.288953801497787e-22	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,RAD21,EZH2,PCBP1
GO:0006351	transcription, DNA-templated	8.5878062987319e-22	8.5878062987319e-22	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0006355	regulation of transcription, DNA-templated	1.0055976587050765e-21	1.0055976587050765e-21	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,EZH2,PCBP1
GO:0016310	phosphorylation	1.2735432481447244e-21	1.2735432481447244e-21	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0048519	negative regulation of biological process	2.2563382296512833e-21	2.2563382296512833e-21	+1	TP53,PIK3CA,PTEN,APC,VHL,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,CDKN2C,EZH2
GO:0042325	regulation of phosphorylation	2.2563382296512833e-21	2.2563382296512833e-21	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,FLT3,NPM1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,NCOR1,AXIN2,CDKN2C,EZH2
GO:2000112	regulation of cellular macromolecule biosynthetic process	2.956542478257435e-21	2.956542478257435e-21	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,EZH2,PCBP1
GO:0010556	regulation of macromolecule biosynthetic process	4.80165097078508e-21	4.80165097078508e-21	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,EZH2,PCBP1
GO:0006468	protein phosphorylation	6.739719065854931e-21	6.739719065854931e-21	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,SMAD2,AXIN2,CDKN2C,EZH2
GO:0031326	regulation of cellular biosynthetic process	6.739719065854931e-21	6.739719065854931e-21	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,EZH2,PCBP1
GO:0016070	RNA metabolic process	1.488293994279692e-20	1.488293994279692e-20	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0031324	negative regulation of cellular metabolic process	1.5976428393418906e-20	1.5976428393418906e-20	+1	TP53,PIK3CA,PTEN,APC,VHL,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,MTOR,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0034654	nucleobase-containing compound biosynthetic process	1.888873647692008e-20	1.888873647692008e-20	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0009889	regulation of biosynthetic process	1.888873647692008e-20	1.888873647692008e-20	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,EZH2,PCBP1
GO:0043412	macromolecule modification	4.097128455094109e-20	4.097128455094109e-20	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,MAP2K4,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:0036211	protein modification process	4.113826758035855e-20	4.113826758035855e-20	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,MAP2K4,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:1902680	positive regulation of RNA biosynthetic process	4.113826758035855e-20	4.113826758035855e-20	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,SMAD2,PCBP1
GO:1903508	positive regulation of nucleic acid-templated transcription	4.113826758035855e-20	4.113826758035855e-20	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,SMAD2,PCBP1
GO:0006464	cellular protein modification process	4.113826758035855e-20	4.113826758035855e-20	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,MAP2K4,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:0044260	cellular macromolecule metabolic process	4.113826758035855e-20	4.113826758035855e-20	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0090304	nucleic acid metabolic process	4.113826758035855e-20	4.113826758035855e-20	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0045893	positive regulation of transcription, DNA-templated	4.113826758035855e-20	4.113826758035855e-20	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,SMAD2,PCBP1
GO:0018130	heterocycle biosynthetic process	4.113826758035855e-20	4.113826758035855e-20	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0019438	aromatic compound biosynthetic process	4.113826758035855e-20	4.113826758035855e-20	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0009892	negative regulation of metabolic process	6.296798313682093e-20	6.296798313682093e-20	+1	TP53,PIK3CA,PTEN,APC,VHL,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,RPL22,STK11,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,CDKN2C,EZH2
GO:0043170	macromolecule metabolic process	8.486847146180299e-20	8.486847146180299e-20	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0042127	regulation of cell population proliferation	1.166023713198514e-19	1.166023713198514e-19	+1	TP53,PTEN,APC,VHL,KRAS,PBRM1,EGFR,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,CTCF,BAP1,NPM1,RUNX1,NRAS,TBX3,STK11,CEBPA,AKT1,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,ERBB4,TLR4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,BRCA2,FGFR3,TGFBR2,CDKN1A,MAPK8IP1,EGR3,LIFR,AXIN2,CDKN2C,EZH2
GO:0010467	gene expression	1.166023713198514e-19	1.166023713198514e-19	+1	TP53,PTEN,VHL,KRAS,ARID1A,NAV3,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2,PCBP1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	1.3387464049607832e-19	1.3387464049607832e-19	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,ASXL1,SOX17,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,SMAD2,ERCC2,PCBP1
GO:0019220	regulation of phosphate metabolic process	2.0795548418483672e-19	2.0795548418483672e-19	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,FLT3,NPM1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,NCOR1,AXIN2,CDKN2C,EZH2
GO:0051174	regulation of phosphorus metabolic process	2.1007734267015846e-19	2.1007734267015846e-19	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,FLT3,NPM1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,NCOR1,AXIN2,CDKN2C,EZH2
GO:0008283	cell population proliferation	2.252896148824593e-19	2.252896148824593e-19	+1	TP53,PTEN,APC,VHL,KRAS,PBRM1,EGFR,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,CTCF,BAP1,NPM1,RUNX1,NRAS,TBX3,STK11,CEBPA,AKT1,AR,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,ERBB4,TLR4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,BRCA2,FGFR3,TGFBR2,CDKN1A,MAPK8IP1,EGR3,MECOM,LIFR,AXIN2,CDKN2C,EZH2
GO:0010557	positive regulation of macromolecule biosynthetic process	2.619830665237262e-19	2.619830665237262e-19	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,PCBP1
GO:1901362	organic cyclic compound biosynthetic process	3.0338989394603754e-19	3.0338989394603754e-19	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0006366	transcription by RNA polymerase II	4.448329654251796e-19	4.448329654251796e-19	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AR,TSHZ2,SOX9,ATM,WT1,HGF,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,CBFB,SIN3A,VEZF1,CDK12,PHF6,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0051254	positive regulation of RNA metabolic process	4.997069291851304e-19	4.997069291851304e-19	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,SMAD2,PCBP1
GO:0051338	regulation of transferase activity	7.103990836589114e-19	7.103990836589114e-19	+1	TP53,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,FLT3,NPM1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,CDKN1B,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,EIF4A2,CDK12,MAPK8IP1,RPL5,CDKN2C,EZH2
GO:0009059	macromolecule biosynthetic process	1.140187604359435e-18	1.140187604359435e-18	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0031399	regulation of protein modification process	1.6409752634295179e-18	1.6409752634295179e-18	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,CTNNB1,FLT3,NPM1,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,KIT,EP300,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,RPL5,AXIN2,CDKN2C,EZH2
GO:0034645	cellular macromolecule biosynthetic process	2.3899747087934912e-18	2.3899747087934912e-18	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0031328	positive regulation of cellular biosynthetic process	2.6491598697034048e-18	2.6491598697034048e-18	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,PCBP1
GO:0006357	regulation of transcription by RNA polymerase II	2.9020172051346096e-18	2.9020172051346096e-18	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AR,TSHZ2,SOX9,ATM,WT1,HGF,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,CBFB,SIN3A,VEZF1,CDK12,PHF6,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,EZH2,PCBP1
GO:0006139	nucleobase-containing compound metabolic process	3.2349203669841616e-18	3.2349203669841616e-18	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0009891	positive regulation of biosynthetic process	5.417336039556527e-18	5.417336039556527e-18	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,EP300,FGFR2,SMAD4,FOXA2,BRCA2,ASXL1,SOX17,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,ACVR2A,MECOM,RPL5,SMAD2,PCBP1
GO:0044271	cellular nitrogen compound biosynthetic process	5.864281627004696e-18	5.864281627004696e-18	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0043549	regulation of kinase activity	5.867065934808498e-18	5.867065934808498e-18	+1	PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,FLT3,NPM1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,CDKN1B,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0010605	negative regulation of macromolecule metabolic process	5.876086289436832e-18	5.876086289436832e-18	+1	TP53,PTEN,APC,VHL,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0007049	cell cycle	6.312840424134501e-18	6.312840424134501e-18	+1	TP53,PTEN,APC,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,TBX3,STK11,CEBPA,AKT1,STAG2,AJUBA,SOX9,ATM,CDKN1B,HGF,MTOR,ATRX,BRCA1,FOXA1,CHEK2,SETD2,EP300,FGFR2,CCND1,BRCA2,CDKN1A,TAF1,PPP2R1A,ATR,SMC1A,ACVR1B,MECOM,SMC3,NCOR1,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0051172	negative regulation of nitrogen compound metabolic process	8.936797209974389e-18	8.936797209974389e-18	+1	TP53,PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,EIF4A2,PHF6,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0048583	regulation of response to stimulus	9.974763058477946e-18	9.974763058477946e-18	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,CBFB,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0046483	heterocycle metabolic process	1.895268316023106e-17	1.895268316023106e-17	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0006725	cellular aromatic compound metabolic process	2.823032617063184e-17	2.823032617063184e-17	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	3.9839074509399746e-17	3.9839074509399746e-17	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,ATM,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,POLQ,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0001932	regulation of protein phosphorylation	5.624640596009414e-17	5.624640596009414e-17	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,FLT3,NPM1,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,AXIN2,CDKN2C,EZH2
GO:0010646	regulation of cell communication	1.3975192562183714e-16	1.3975192562183714e-16	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,ARHGAP35,NFE2L2,RUNX1,MAP2K4,STK11,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,CBFB,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0009966	regulation of signal transduction	2.2203321505674875e-16	2.2203321505674875e-16	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,ARHGAP35,NFE2L2,RUNX1,MAP2K4,STK11,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,CBFB,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0023051	regulation of signaling	2.5892447288896114e-16	2.5892447288896114e-16	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,ARHGAP35,NFE2L2,RUNX1,MAP2K4,STK11,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,CBFB,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0051726	regulation of cell cycle	2.901186192759446e-16	2.901186192759446e-16	+1	TP53,PTEN,APC,EGFR,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,TBX3,STK11,CEBPA,AKT1,SOX9,ATM,CDKN1B,MTOR,ATRX,BRCA1,FOXA1,CHEK2,SETD2,EP300,FGFR2,CCND1,CDKN1A,TAF1,PPP2R1A,ATR,MECOM,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:1903507	negative regulation of nucleic acid-templated transcription	3.541752855282259e-16	3.541752855282259e-16	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:1902679	negative regulation of RNA biosynthetic process	3.5907855684655153e-16	3.5907855684655153e-16	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:1901360	organic cyclic compound metabolic process	3.5907855684655153e-16	3.5907855684655153e-16	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0006807	nitrogen compound metabolic process	7.067475188011264e-16	7.067475188011264e-16	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0045595	regulation of cell differentiation	7.679330383709071e-16	7.679330383709071e-16	+1	PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,TBX3,EPHA3,AKT1,AR,SOX9,HGF,MTOR,TLR4,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,ASXL1,TGFBR2,PPP2R1A,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0051253	negative regulation of RNA metabolic process	8.6583662027312e-16	8.6583662027312e-16	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0048513	animal organ development	1.0512647193781281e-15	1.0512647193781281e-15	+1	TP53,PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,ARHGAP35,RUNX1,TBX3,CEBPA,EPHA3,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,SIN3A,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,EZH2
GO:0044238	primary metabolic process	1.1214146731757786e-15	1.1214146731757786e-15	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0044249	cellular biosynthetic process	1.3196113173438972e-15	1.3196113173438972e-15	+1	TP53,PIK3CA,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0044237	cellular metabolic process	1.5076242837192678e-15	1.5076242837192678e-15	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,IDH1,TBX3,MAP2K4,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0031327	negative regulation of cellular biosynthetic process	1.5213192001524085e-15	1.5213192001524085e-15	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,CBFB,ATR,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0045892	negative regulation of transcription, DNA-templated	1.9739615423300395e-15	1.9739615423300395e-15	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0010558	negative regulation of macromolecule biosynthetic process	2.492398404243299e-15	2.492398404243299e-15	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,CBFB,ATR,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0050793	regulation of developmental process	2.568694050228851e-15	2.568694050228851e-15	+1	PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,AR,EPPK1,SOX9,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0009890	negative regulation of biosynthetic process	2.568694050228851e-15	2.568694050228851e-15	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,CBFB,ATR,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:1901576	organic substance biosynthetic process	3.1793491397526543e-15	3.1793491397526543e-15	+1	TP53,PIK3CA,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0007275	multicellular organism development	3.4809070450669654e-15	3.4809070450669654e-15	+1	TP53,PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0051276	chromosome organization	3.822174764412998e-15	3.822174764412998e-15	+1	TP53,APC,ARID1A,PBRM1,CDKN2A,RB1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,KDM6A,STAG2,SOX9,ATM,KDM5C,TET2,ATRX,BRCA1,FOXA1,SETD2,EP300,SMAD4,BRCA2,ASXL1,ATR,SIN3A,HIST1H2BD,SMC1A,NSD1,TBL1XR1,MECOM,SMC3,AXIN2,RAD21,ERCC2,EZH2
GO:0034641	cellular nitrogen compound metabolic process	4.0750177109960806e-15	4.0750177109960806e-15	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0045944	positive regulation of transcription by RNA polymerase II	4.327194019365129e-15	4.327194019365129e-15	+1	TP53,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,NFE2L2,NPM1,RUNX1,CEBPA,AR,SOX9,ATM,WT1,HGF,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,EP300,FGFR2,SMAD4,FOXA2,ASXL1,SOX17,SIN3A,VEZF1,CDK12,TBL1XR1,ACVR2A,SMAD2,PCBP1
GO:0009058	biosynthetic process	7.01510921782268e-15	7.01510921782268e-15	+1	TP53,PIK3CA,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2,PCBP1
GO:0044267	cellular protein metabolic process	7.218296129413687e-15	7.218296129413687e-15	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,MAP2K4,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,EIF4A2,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:0051246	regulation of protein metabolic process	7.570224356131368e-15	7.570224356131368e-15	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,CTNNB1,FLT3,KEAP1,NFE2L2,NPM1,RUNX1,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,CHEK2,KIT,EP300,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,RPL5,SPOP,AXIN2,CDKN2C,EZH2
GO:0048731	system development	8.009630905242854e-15	8.009630905242854e-15	+1	TP53,PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,SIN3A,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:2000113	negative regulation of cellular macromolecule biosynthetic process	1.041885959379447e-14	1.041885959379447e-14	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,CBFB,ATR,SIN3A,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0048869	cellular developmental process	1.2301461907294995e-14	1.2301461907294995e-14	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,ARHGAP35,NPM1,RUNX1,TBX3,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,PRX,ERBB4,MTOR,TLR4,TET2,ELF3,LRRK2,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0040007	growth	2.061702585346427e-14	2.061702585346427e-14	+1	TP53,PTEN,EGFR,CDKN2A,RB1,NOTCH1,CTNNB1,BAP1,RUNX1,STK11,AKT1,EPPK1,SOX9,CDKN1B,WT1,ERBB4,MTOR,FGFR2,SMAD4,USP9X,FGFR3,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,CDKN2C
GO:0006915	apoptotic process	2.2121504528939358e-14	2.2121504528939358e-14	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,ERCC2
GO:0012501	programmed cell death	2.786407189307092e-14	2.786407189307092e-14	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,MECOM,ERCC2
GO:0006796	phosphate-containing compound metabolic process	3.180891564027067e-14	3.180891564027067e-14	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0018193	peptidyl-amino acid modification	3.21079103094946e-14	3.21079103094946e-14	+1	TP53,PTEN,EGFR,CDKN2A,FBXW7,CTNNB1,FLT3,KDM6A,EPHA3,AKT1,BRAF,ATM,HGF,ERBB4,MTOR,TET2,ATRX,BRCA1,LRRK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,BRCA2,FGFR3,TGFBR2,TAF1,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,NSD1,EZH2
GO:0008285	negative regulation of cell population proliferation	3.674412261149444e-14	3.674412261149444e-14	+1	TP53,PTEN,APC,VHL,PBRM1,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,STK11,CEBPA,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,ERBB4,FGFR2,BRCA2,CDKN1A,AXIN2,CDKN2C
GO:0006793	phosphorus metabolic process	4.858005510678236e-14	4.858005510678236e-14	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0065009	regulation of molecular function	5.002480388735138e-14	5.002480388735138e-14	+1	TP53,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CTCF,NPM1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,CDKN1B,HGF,ERBB4,MTOR,TLR4,ARID5B,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,CDK12,MAPK8IP1,NSD1,RPL5,SMAD2,CDKN2C,EZH2
GO:0032268	regulation of cellular protein metabolic process	5.485251752159558e-14	5.485251752159558e-14	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,FBXW7,CTNNB1,FLT3,KEAP1,NFE2L2,NPM1,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,KIT,EP300,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,RPL5,AXIN2,CDKN2C,EZH2
GO:0051128	regulation of cellular component organization	5.487935302899697e-14	5.487935302899697e-14	+1	TP53,PIK3CA,PTEN,APC,NAV3,EGFR,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,STK11,EPHA3,AKT1,AR,AJUBA,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,PDGFRA,EP300,SMAD4,SOX17,CDKN1A,PPP2R1A,CBFB,ATR,SIN3A,PTPN11,ACVR1B,NSD1,AXIN2,MIR142,RAD21,ERCC2,CDKN2C
GO:0048584	positive regulation of response to stimulus	6.178640424905172e-14	6.178640424905172e-14	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,NFE2L2,RUNX1,NRAS,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,ELF3,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,CBFB,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0008219	cell death	8.497380075877251e-14	8.497380075877251e-14	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,MECOM,AXIN2,ERCC2
GO:0040008	regulation of growth	1.1927410757135742e-13	1.1927410757135742e-13	+1	TP53,PTEN,EGFR,CDKN2A,RB1,NOTCH1,BAP1,RUNX1,STK11,AKT1,EPPK1,CDKN1B,WT1,ERBB4,MTOR,FGFR2,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,CDKN2C
GO:0070887	cellular response to chemical stimulus	1.2882370415756379e-13	1.2882370415756379e-13	+1	TP53,PIK3CA,APC,VHL,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CDH1,NFE2L2,NPM1,RUNX1,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,TGFBR2,CDKN1A,TAF1,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2
GO:0048856	anatomical structure development	1.7157434182454863e-13	1.7157434182454863e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0071495	cellular response to endogenous stimulus	2.282652489681664e-13	2.282652489681664e-13	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,CDH1,RUNX1,STK11,AKT1,AR,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,FOXA1,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,TAF1,CBFB,SMC1A,PTPN11,EGR3,ACVR2A,NCOR1,SMAD2
GO:0019538	protein metabolic process	2.565881401464047e-13	2.565881401464047e-13	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,RUNX1,MAP2K4,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,EIF4A2,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:0045859	regulation of protein kinase activity	3.074475745211296e-13	3.074475745211296e-13	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,FBXW7,FLT3,NPM1,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,CDKN1B,MTOR,TLR4,LRRK2,KIT,CCND1,TGFBR2,CDKN1A,PPP2R1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0009628	response to abiotic stimulus	3.8844982434104666e-13	3.8844982434104666e-13	+1	TP53,PIK3CA,PTEN,VHL,EGFR,NF1,GATA3,NOTCH1,FBXW7,CTNNB1,MAP3K1,NFE2L2,NPM1,MAP2K4,STK11,AKT1,AJUBA,SOX9,ATM,MTOR,TLR4,BRCA1,KIT,EP300,CCND1,SMAD4,CDKN1A,TAF1,ATR,SMC1A,ERCC2
GO:0009967	positive regulation of signal transduction	3.925551185106819e-13	3.925551185106819e-13	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,EZH2
GO:0032502	developmental process	4.747361827919941e-13	4.747361827919941e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,NPM1,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:1902531	regulation of intracellular signal transduction	4.956672212940722e-13	4.956672212940722e-13	+1	TP53,PIK3CA,PTEN,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,ARHGAP35,NFE2L2,MAP2K4,STK11,AKT1,BRAF,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,BRCA1,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,TAF1,PPP2R1A,ATR,PTPN11,MAPK8IP1,MECOM,NCOR1,RPL5,EZH2
GO:0010033	response to organic substance	5.226680010894851e-13	5.226680010894851e-13	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,FLT3,CDH1,NFE2L2,NPM1,RUNX1,STK11,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2,MIR142
GO:0022402	cell cycle process	5.909837350333808e-13	5.909837350333808e-13	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,CTCF,NPM1,STK11,AKT1,STAG2,AJUBA,SOX9,ATM,CDKN1B,MTOR,ATRX,BRCA1,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,TAF1,PPP2R1A,SMC1A,ACVR1B,SMC3,NCOR1,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0042327	positive regulation of phosphorylation	6.373762291681358e-13	6.373762291681358e-13	+1	TP53,KRAS,EGFR,FBXW7,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,ACVR2A,AXIN2,EZH2
GO:1902806	regulation of cell cycle G1/S phase transition	6.705257113615978e-13	6.705257113615978e-13	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,FBXW7,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,TAF1,CDKN2C,EZH2
GO:0016043	cellular component organization	6.74291252153073e-13	6.74291252153073e-13	+1	TP53,PIK3CA,PTEN,APC,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,IDH1,STK11,KDM6A,EPHA3,AKT1,STAG2,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,USP9X,BRCA2,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,SMC1A,PTPN11,ACVR1B,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2
GO:0009719	response to endogenous stimulus	7.145356920425977e-13	7.145356920425977e-13	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,CDH1,RUNX1,STK11,AKT1,AR,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,FOXA1,EP300,FGFR2,CCND1,SMAD4,USP9X,FGFR3,TGFBR2,TAF1,CBFB,SMC1A,PTPN11,EGR3,ACVR2A,NCOR1,SMAD2
GO:0060485	mesenchyme development	9.083945423548902e-13	9.083945423548902e-13	+1	PTEN,GATA3,NOTCH1,CTNNB1,EPHA3,SOX9,WT1,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0048762	mesenchymal cell differentiation	9.237049467635044e-13	9.237049467635044e-13	+1	PTEN,GATA3,NOTCH1,CTNNB1,EPHA3,SOX9,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0010647	positive regulation of cell communication	9.331455668993332e-13	9.331455668993332e-13	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,TSHZ3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,EZH2
GO:0023056	positive regulation of signaling	1.0594781128096735e-12	1.0594781128096735e-12	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,TSHZ3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,EZH2
GO:0051247	positive regulation of protein metabolic process	1.373377105641316e-12	1.373377105641316e-12	+1	TP53,PTEN,APC,KRAS,EGFR,CDKN2A,FBXW7,CTNNB1,FLT3,KEAP1,NFE2L2,NPM1,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PTPN11,ACVR2A,RPL5,AXIN2,EZH2
GO:0001837	epithelial to mesenchymal transition	1.3802349071567072e-12	1.3802349071567072e-12	+1	PTEN,GATA3,NOTCH1,CTNNB1,EPHA3,SOX9,HGF,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0030154	cell differentiation	1.430620239087148e-12	1.430620239087148e-12	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,ARHGAP35,RUNX1,TBX3,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,PRX,ERBB4,MTOR,TLR4,TET2,ELF3,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,PPP2R1A,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0042221	response to chemical	1.4746164468161194e-12	1.4746164468161194e-12	+1	TP53,PIK3CA,APC,VHL,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CDH1,ARHGAP35,NFE2L2,NPM1,RUNX1,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2,MIR142
GO:0006950	response to stress	1.5477853650445656e-12	1.5477853650445656e-12	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,KEAP1,ARHGAP35,NFE2L2,NPM1,NRAS,TBX3,MAP2K4,STK11,CEBPA,AKT1,BRAF,AJUBA,EPPK1,PIK3CG,ATM,CDKN1B,HGF,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,KIT,SETD2,PDGFRA,EP300,CCND1,SMAD4,FOXA2,BRCA2,CDKN1A,TAF1,ATR,SIN3A,VEZF1,SMC1A,PTPN11,MAPK8IP1,MECOM,NCOR1,AXIN2,MIR142,RAD21,ERCC2
GO:0000122	negative regulation of transcription by RNA polymerase II	1.6666590967392588e-12	1.6666590967392588e-12	+1	TP53,VHL,GATA3,RB1,NOTCH1,DNMT3A,CTCF,RUNX1,TBX3,AR,SOX9,WT1,ARID5B,ATRX,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,NCOR1,SMAD2,EZH2
GO:0048732	gland development	1.8434300547880917e-12	1.8434300547880917e-12	+1	NF1,GATA3,FBXW7,ARHGAP35,TBX3,CEBPA,AKT1,SOX9,WT1,HGF,ERBB4,ARID5B,ELF3,FGFR2,BRCA2
GO:0035556	intracellular signal transduction	1.845523935817185e-12	1.845523935817185e-12	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,FLT3,ARHGAP35,NFE2L2,NRAS,MAP2K4,STK11,AKT1,BRAF,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,CDKN1A,TAF1,PPP2R1A,ATR,PTPN11,MAPK8IP1,MECOM,NCOR1,RPL5,SMAD2,EZH2
GO:0050794	regulation of cellular process	2.1727553976209105e-12	2.1727553976209105e-12	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,SMC3,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0071310	cellular response to organic substance	2.511489616769263e-12	2.511489616769263e-12	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,NOTCH1,CTNNB1,FLT3,CDH1,NFE2L2,NPM1,RUNX1,STK11,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,TGFBR2,CDKN1A,TAF1,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2
GO:0071900	regulation of protein serine/threonine kinase activity	2.8051704975679817e-12	2.8051704975679817e-12	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,FLT3,MAP2K4,CEBPA,AKT1,PIK3CG,CDKN1B,TLR4,LRRK2,KIT,CCND1,CDKN1A,PPP2R1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0006325	chromatin organization	2.848856638091879e-12	2.848856638091879e-12	+1	TP53,ARID1A,PBRM1,CDKN2A,RB1,CTNNB1,CTCF,BAP1,NPM1,KDM6A,SOX9,KDM5C,TET2,ATRX,BRCA1,FOXA1,SETD2,EP300,SMAD4,BRCA2,ASXL1,SIN3A,HIST1H2BD,NSD1,TBL1XR1,MECOM,EZH2
GO:0010717	regulation of epithelial to mesenchymal transition	3.131138470805265e-12	3.131138470805265e-12	+1	PTEN,GATA3,NOTCH1,CTNNB1,EPHA3,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0010562	positive regulation of phosphorus metabolic process	3.175847572165059e-12	3.175847572165059e-12	+1	TP53,KRAS,EGFR,FBXW7,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,ACVR2A,AXIN2,EZH2
GO:0045937	positive regulation of phosphate metabolic process	3.175847572165059e-12	3.175847572165059e-12	+1	TP53,KRAS,EGFR,FBXW7,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,ACVR2A,AXIN2,EZH2
GO:0071840	cellular component organization or biogenesis	3.717399318009047e-12	3.717399318009047e-12	+1	TP53,PIK3CA,PTEN,APC,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,IDH1,STK11,KDM6A,EPHA3,AKT1,STAG2,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,USP9X,BRCA2,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,SMC1A,PTPN11,ACVR1B,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2
GO:0046777	protein autophosphorylation	3.828923904992137e-12	3.828923904992137e-12	+1	EGFR,FLT3,STK11,AKT1,ATM,ERBB4,MTOR,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,FGFR3,TAF1,ATR,CDK12,ACVR1B
GO:0051716	cellular response to stimulus	3.89058367217884e-12	3.89058367217884e-12	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SMC1A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2
GO:0010564	regulation of cell cycle process	4.868946545801132e-12	4.868946545801132e-12	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,FBXW7,CTNNB1,CTCF,NPM1,AKT1,SOX9,ATM,CDKN1B,ATRX,BRCA1,CHEK2,SETD2,EP300,CCND1,CDKN1A,TAF1,PPP2R1A,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0032270	positive regulation of cellular protein metabolic process	5.458099759157759e-12	5.458099759157759e-12	+1	TP53,PTEN,KRAS,EGFR,CDKN2A,FBXW7,CTNNB1,FLT3,KEAP1,NFE2L2,NPM1,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PTPN11,ACVR2A,RPL5,AXIN2,EZH2
GO:0033554	cellular response to stress	7.455367398471668e-12	7.455367398471668e-12	+1	TP53,PIK3CA,APC,VHL,EGFR,PIK3R1,CDKN2A,NOTCH1,FBXW7,KEAP1,NFE2L2,NPM1,TBX3,MAP2K4,STK11,AKT1,BRAF,AJUBA,ATM,CDKN1B,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,POLQ,CHEK2,SETD2,PDGFRA,EP300,CCND1,BRCA2,CDKN1A,TAF1,ATR,SMC1A,MAPK8IP1,MECOM,NCOR1,AXIN2,RAD21,ERCC2
GO:0009888	tissue development	1.1239867237303953e-11	1.1239867237303953e-11	+1	TP53,PTEN,NF1,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,EPPK1,SOX9,CDKN1B,WT1,HGF,ERBB4,MTOR,ARID5B,FOXA1,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,BRCA2,FGFR3,TGFBR2,SOX17,CDKN1A,CBFB,VEZF1,PTPN11,ACVR2A,SMAD2,AXIN2,ERCC2,EZH2
GO:0007507	heart development	1.535194411688762e-11	1.535194411688762e-11	+1	PTEN,EGFR,NF1,GATA3,RB1,NOTCH1,CTNNB1,RUNX1,TBX3,SOX9,CDKN1B,WT1,ERBB4,PDGFRA,FGFR2,SMAD4,TGFBR2,SOX17,CDKN1A,PTPN11
GO:0016049	cell growth	2.0884524479360995e-11	2.0884524479360995e-11	+1	TP53,EGFR,CDKN2A,RB1,CTNNB1,BAP1,STK11,AKT1,SOX9,CDKN1B,WT1,MTOR,SMAD4,USP9X,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,CDKN2C
GO:0031401	positive regulation of protein modification process	2.275696750880274e-11	2.275696750880274e-11	+1	TP53,PTEN,KRAS,EGFR,CDKN2A,FBXW7,CTNNB1,FLT3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,ACVR2A,AXIN2,EZH2
GO:0044843	cell cycle G1/S phase transition	4.0385062613970675e-11	4.0385062613970675e-11	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,FBXW7,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,TAF1,ACVR1B,CDKN2C,EZH2
GO:0048585	negative regulation of response to stimulus	4.569834653755625e-11	4.569834653755625e-11	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,AKT1,AR,AJUBA,EPPK1,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,POLQ,PDGFRA,SMAD4,FOXA2,ASXL1,TGFBR2,SOX17,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,MIR142,EZH2
GO:0007062	sister chromatid cohesion	6.963568400644621e-11	6.963568400644621e-11	+1	RB1,FBXW7,CTNNB1,CTCF,STAG2,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0007154	cell communication	7.747385765890495e-11	7.747385765890495e-11	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0006996	organelle organization	7.851562468575926e-11	7.851562468575926e-11	+1	TP53,PIK3CA,PTEN,APC,ARID1A,PBRM1,NAV3,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,CTCF,BAP1,NPM1,IDH1,KDM6A,EPHA3,AKT1,STAG2,AJUBA,EPPK1,SOX9,ATM,HGF,KDM5C,ERBB4,MTOR,TET2,ATRX,BRCA1,LRRK2,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,SMAD4,USP9X,BRCA2,ASXL1,PPP2R1A,ATR,SIN3A,HIST1H2BD,SMC1A,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,RPL5,AXIN2,RAD21,ERCC2,EZH2
GO:0023052	signaling	7.891650844973366e-11	7.891650844973366e-11	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0010941	regulation of cell death	8.551175231741089e-11	8.551175231741089e-11	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,TLR4,BRCA1,LRRK2,FOXA1,FGFR2,EGR3,MECOM,AXIN2
GO:0001934	positive regulation of protein phosphorylation	8.735737905264088e-11	8.735737905264088e-11	+1	TP53,KRAS,EGFR,FBXW7,FLT3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,ACVR2A,AXIN2,EZH2
GO:0045787	positive regulation of cell cycle	9.472098492409256e-11	9.472098492409256e-11	+1	TP53,EGFR,CDKN2A,RB1,NPM1,TBX3,AKT1,ATM,CDKN1B,ATRX,BRCA1,FOXA1,CHEK2,EP300,FGFR2,CCND1,CDKN1A,RAD21,EZH2
GO:0080134	regulation of response to stress	9.641581674550597e-11	9.641581674550597e-11	+1	PTEN,KRAS,EGFR,PIK3R1,CDKN2A,GATA3,RB1,FBXW7,NFE2L2,NPM1,NRAS,CEBPA,AKT1,AJUBA,EPPK1,ATM,HGF,MTOR,TLR4,BRCA1,LRRK2,POLQ,SETD2,PDGFRA,EP300,FOXA2,ATR,SIN3A,PTPN11,MAPK8IP1,MECOM,NCOR1,AXIN2,MIR142
GO:0050790	regulation of catalytic activity	1.041483834697044e-10	1.041483834697044e-10	+1	TP53,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,FLT3,NPM1,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,EIF4A2,CDK12,MAPK8IP1,RPL5,CDKN2C,EZH2
GO:1901987	regulation of cell cycle phase transition	1.5493047601680086e-10	1.5493047601680086e-10	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,FBXW7,NPM1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,TAF1,PPP2R1A,ERCC2,CDKN2C,EZH2
GO:0045926	negative regulation of growth	1.5725198093784066e-10	1.5725198093784066e-10	+1	TP53,PTEN,CDKN2A,RB1,NOTCH1,STK11,CDKN1B,WT1,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0007165	signal transduction	1.798365479156288e-10	1.798365479156288e-10	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0000165	MAPK cascade	2.0583121665914663e-10	2.0583121665914663e-10	+1	PTEN,KRAS,EGFR,NF1,NOTCH1,FBXW7,FLT3,NRAS,MAP2K4,BRAF,PIK3CG,SOX9,HGF,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PPP2R1A,PTPN11,MAPK8IP1,MECOM,NCOR1,EZH2
GO:1901564	organonitrogen compound metabolic process	2.169181937306056e-10	2.169181937306056e-10	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,RUNX1,MAP2K4,RPL22,STK11,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,EIF4A2,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,NCOR1,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:0009968	negative regulation of signal transduction	2.4868338925249587e-10	2.4868338925249587e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,TGFBR2,SOX17,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:2000045	regulation of G1/S transition of mitotic cell cycle	2.626970726252527e-10	2.626970726252527e-10	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0010628	positive regulation of gene expression	3.7669022740563513e-10	3.7669022740563513e-10	+1	TP53,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CTCF,NFE2L2,NPM1,RUNX1,AKT1,BRAF,AR,SOX9,ATM,WT1,MTOR,TLR4,BRCA1,SETD2,EP300,SF3B1,PTPN11,NCOR1,RPL5,AXIN2
GO:0014065	phosphatidylinositol 3-kinase signaling	3.895616170483653e-10	3.895616170483653e-10	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0000278	mitotic cell cycle	4.123246606895921e-10	4.123246606895921e-10	+1	TP53,PTEN,APC,PBRM1,EGFR,CDKN2A,RB1,CTNNB1,AKT1,STAG2,AJUBA,ATM,CDKN1B,HGF,ATRX,FOXA1,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,PPP2R1A,SMC1A,ACVR1B,SMC3,RAD21,ERCC2,CDKN2C
GO:0045786	negative regulation of cell cycle	4.416201246751903e-10	4.416201246751903e-10	+1	TP53,PTEN,APC,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,NPM1,STK11,CEBPA,ATM,CDKN1B,MTOR,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR,CDKN2C,EZH2
GO:0051348	negative regulation of transferase activity	5.490272155460288e-10	5.490272155460288e-10	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,EIF4A2,MAPK8IP1,RPL5
GO:0007166	cell surface receptor signaling pathway	5.891858910877645e-10	5.891858910877645e-10	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,RUNX1,NRAS,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,SOX9,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,FGFR3,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,PTPN11,ACVR1B,TBL1XR1,ACVR2A,LIFR,SMAD2,AXIN2
GO:0050896	response to stimulus	5.89585288668168e-10	5.89585288668168e-10	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,SMC1A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2
GO:0071214	cellular response to abiotic stimulus	6.029880738027979e-10	6.029880738027979e-10	+1	TP53,PIK3CA,PTEN,GATA3,FBXW7,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
GO:0104004	cellular response to environmental stimulus	6.029880738027979e-10	6.029880738027979e-10	+1	TP53,PIK3CA,PTEN,GATA3,FBXW7,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
GO:0072359	circulatory system development	6.029880738027979e-10	6.029880738027979e-10	+1	PIK3CA,PTEN,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,TBX3,STK11,AKT1,SOX9,CDKN1B,WT1,ERBB4,BRCA1,KIT,PDGFRA,FGFR2,SMAD4,TGFBR2,SOX17,CDKN1A,PTPN11,EGR3
GO:0007050	cell cycle arrest	6.359468196260832e-10	6.359468196260832e-10	+1	TP53,APC,CDKN2A,RB1,NOTCH1,STK11,ATM,CDKN1B,MTOR,BRCA1,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0044770	cell cycle phase transition	6.734882216582621e-10	6.734882216582621e-10	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,FBXW7,NPM1,AKT1,AJUBA,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,TAF1,PPP2R1A,ACVR1B,ERCC2,CDKN2C,EZH2
GO:0010648	negative regulation of cell communication	6.734882216582621e-10	6.734882216582621e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,TGFBR2,SOX17,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0033674	positive regulation of kinase activity	7.130824721861246e-10	7.130824721861246e-10	+1	EGFR,FBXW7,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,PIK3CG,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,EZH2
GO:0023057	negative regulation of signaling	7.249409185553723e-10	7.249409185553723e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,TGFBR2,SOX17,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0043067	regulation of programmed cell death	7.696925963678846e-10	7.696925963678846e-10	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,ERBB4,BRCA1,LRRK2,FOXA1,FGFR2,EGR3,MECOM
GO:0051239	regulation of multicellular organismal process	7.920464499816562e-10	7.920464499816562e-10	+1	PTEN,APC,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,TSHZ3,RUNX1,STK11,AKT1,EPPK1,PIK3CG,SOX9,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,BRCA2,TGFBR2,SOX17,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0043408	regulation of MAPK cascade	8.561960274219722e-10	8.561960274219722e-10	+1	PTEN,EGFR,NF1,NOTCH1,FBXW7,FLT3,MAP2K4,BRAF,PIK3CG,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PPP2R1A,PTPN11,MAPK8IP1,MECOM,NCOR1,EZH2
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	1.0917262127408518e-9	1.0917262127408518e-9	+1	TP53,PTEN,APC,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0051052	regulation of DNA metabolic process	1.2776980619843826e-9	1.2776980619843826e-9	+1	TP53,EGFR,CDKN2A,NPM1,AKT1,ATM,WT1,HGF,ATRX,BRCA1,POLQ,SETD2,USP9X,CDKN1A,ATR,AXIN2,ERCC2
GO:0007167	enzyme linked receptor protein signaling pathway	1.3081199195529815e-9	1.3081199195529815e-9	+1	PIK3CA,APC,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,STK11,EPHA3,AKT1,BRAF,SOX9,HGF,ERBB4,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,PTPN11,ACVR1B,ACVR2A,LIFR,SMAD2
GO:0051347	positive regulation of transferase activity	1.5020880138585562e-9	1.5020880138585562e-9	+1	PTEN,EGFR,FBXW7,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,PIK3CG,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,EZH2
GO:0090068	positive regulation of cell cycle process	1.6809481448257573e-9	1.6809481448257573e-9	+1	TP53,EGFR,CDKN2A,RB1,NPM1,AKT1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,RAD21,EZH2
GO:1902807	negative regulation of cell cycle G1/S phase transition	1.7275606845654922e-9	1.7275606845654922e-9	+1	TP53,PTEN,APC,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0001558	regulation of cell growth	1.7628696365240022e-9	1.7628696365240022e-9	+1	TP53,EGFR,CDKN2A,RB1,BAP1,STK11,AKT1,CDKN1B,WT1,MTOR,SMAD4,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,CDKN2C
GO:0043069	negative regulation of programmed cell death	1.7628696365240022e-9	1.7628696365240022e-9	+1	TP53,PIK3CA,VHL,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,WT1,HGF,ERBB4,BRCA1,LRRK2,FGFR2,EGR3,MECOM
GO:0042981	regulation of apoptotic process	1.7659713284085903e-9	1.7659713284085903e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,ERBB4,BRCA1,LRRK2,FOXA1,FGFR2,EGR3
GO:1902533	positive regulation of intracellular signal transduction	1.976275604505139e-9	1.976275604505139e-9	+1	TP53,PIK3CA,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,MAP2K4,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,LRRK2,KIT,PDGFRA,EP300,FGFR2,FGFR3,ATR,PTPN11,MAPK8IP1,EZH2
GO:0009314	response to radiation	2.447319747236685e-9	2.447319747236685e-9	+1	TP53,EGFR,NF1,GATA3,FBXW7,NPM1,STK11,AKT1,ATM,BRCA1,EP300,CCND1,CDKN1A,TAF1,ATR,SMC1A,ERCC2
GO:0009411	response to UV	2.9169999503171284e-9	2.9169999503171284e-9	+1	TP53,EGFR,FBXW7,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
GO:0009653	anatomical structure morphogenesis	3.3094351770362968e-9	3.3094351770362968e-9	+1	PIK3CA,PTEN,VHL,NF1,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,BRAF,SOX9,WT1,HGF,ERBB4,MTOR,ELF3,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,SIN3A,PTPN11,EGR3,SMAD2,AXIN2
GO:0051094	positive regulation of developmental process	3.4079481430433348e-9	3.4079481430433348e-9	+1	VHL,CDKN2A,GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,AR,SOX9,WT1,HGF,ERBB4,MTOR,BRCA1,KIT,FGFR2,SMAD4,FOXA2,TGFBR2,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0044093	positive regulation of molecular function	3.669981390704965e-9	3.669981390704965e-9	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,FLT3,NPM1,MAP2K4,STK11,EPHA3,AKT1,BRAF,AR,PIK3CG,ERBB4,MTOR,TLR4,ARID5B,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,TAF1,EZH2
GO:0022607	cellular component assembly	4.276083943343485e-9	4.276083943343485e-9	+1	TP53,PIK3CA,PTEN,APC,NAV3,PIK3R1,CDKN2A,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,CTCF,NPM1,RUNX1,EPHA3,STAG2,AJUBA,EPPK1,SOX9,ATM,TLR4,ATRX,BRCA1,LRRK2,POLQ,CHEK2,KIT,PDGFRA,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,CBFB,ATR,HIST1H2BD,SMC1A,PTPN11,SMC3,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2
GO:0048015	phosphatidylinositol-mediated signaling	4.572170931012867e-9	4.572170931012867e-9	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0048017	inositol lipid-mediated signaling	5.265457825630741e-9	5.265457825630741e-9	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0043066	negative regulation of apoptotic process	5.675534185590697e-9	5.675534185590697e-9	+1	TP53,PIK3CA,VHL,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,WT1,HGF,ERBB4,BRCA1,LRRK2,FGFR2,EGR3
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	8.52762443172642e-9	8.52762443172642e-9	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:0000082	G1/S transition of mitotic cell cycle	8.71068568525455e-9	8.71068568525455e-9	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,ACVR1B,CDKN2C
GO:0071363	cellular response to growth factor stimulus	8.912197799530905e-9	8.912197799530905e-9	+1	PIK3CA,EGFR,GATA3,NOTCH1,CTNNB1,STK11,AKT1,SOX9,HGF,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,PTPN11,ACVR1B,EGR3,ACVR2A,SMAD2
GO:0051093	negative regulation of developmental process	1.1368536331979266e-8	1.1368536331979266e-8	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,TBX3,SOX9,CDKN1B,WT1,TLR4,FOXA1,SMAD4,FOXA2,FGFR3,ASXL1,CDKN1A,CBFB,PTPN11
GO:1903047	mitotic cell cycle process	1.2077761355234637e-8	1.2077761355234637e-8	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,AKT1,STAG2,AJUBA,ATM,CDKN1B,ATRX,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,PPP2R1A,SMC1A,ACVR1B,SMC3,RAD21,ERCC2,CDKN2C
GO:0060548	negative regulation of cell death	1.2777672260874834e-8	1.2777672260874834e-8	+1	TP53,PIK3CA,VHL,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,WT1,HGF,ERBB4,BRCA1,LRRK2,FGFR2,EGR3,MECOM
GO:0080135	regulation of cellular response to stress	1.305763172922393e-8	1.305763172922393e-8	+1	EGFR,PIK3R1,CDKN2A,FBXW7,NFE2L2,NPM1,AKT1,AJUBA,ATM,HGF,MTOR,TLR4,BRCA1,LRRK2,POLQ,SETD2,EP300,ATR,MAPK8IP1,MECOM,NCOR1,AXIN2
GO:1904029	regulation of cyclin-dependent protein kinase activity	1.3112713622596352e-8	1.3112713622596352e-8	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:0030308	negative regulation of cell growth	1.3162332867672677e-8	1.3162332867672677e-8	+1	TP53,CDKN2A,RB1,STK11,CDKN1B,WT1,SMAD4,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0009887	animal organ morphogenesis	1.3661464181837559e-8	1.3661464181837559e-8	+1	PTEN,NF1,GATA3,NOTCH1,FBXW7,CTNNB1,TBX3,BRAF,SOX9,WT1,HGF,ELF3,LRRK2,PDGFRA,FGFR2,SMAD4,FGFR3,ASXL1,TGFBR2,SOX17,SMAD2,AXIN2
GO:0070848	response to growth factor	1.4234647543729432e-8	1.4234647543729432e-8	+1	PIK3CA,EGFR,GATA3,NOTCH1,CTNNB1,STK11,AKT1,SOX9,HGF,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,PTPN11,ACVR1B,EGR3,ACVR2A,SMAD2
GO:0045597	positive regulation of cell differentiation	1.4354656797901372e-8	1.4354656797901372e-8	+1	VHL,GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,AR,SOX9,HGF,MTOR,KIT,SMAD4,TGFBR2,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0010718	positive regulation of epithelial to mesenchymal transition	1.9230670242435824e-8	1.9230670242435824e-8	+1	NOTCH1,CTNNB1,MTOR,SMAD4,TGFBR2,SMAD2,AXIN2,EZH2
GO:1901700	response to oxygen-containing compound	2.0121469140120368e-8	2.0121469140120368e-8	+1	TP53,PIK3CA,APC,EGFR,PIK3R1,CTNNB1,CDH1,NFE2L2,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,FOXA1,PDGFRA,FOXA2,ASXL1,TGFBR2,TAF1,PTPN11,SMAD2,MIR142
GO:0006974	cellular response to DNA damage stimulus	2.0121469140120368e-8	2.0121469140120368e-8	+1	TP53,APC,EGFR,CDKN2A,FBXW7,NPM1,STK11,ATM,CDKN1B,ATRX,BRCA1,POLQ,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,TAF1,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:0008284	positive regulation of cell population proliferation	2.077041206162166e-8	2.077041206162166e-8	+1	PTEN,KRAS,EGFR,NOTCH1,CTNNB1,FLT3,NPM1,NRAS,TBX3,AKT1,AR,SOX9,ERBB4,TLR4,PDGFRA,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,EGR3,LIFR,EZH2
GO:0051896	regulation of protein kinase B signaling	2.1126375276463025e-8	2.1126375276463025e-8	+1	PIK3CA,PTEN,EGFR,PIK3R1,GATA3,AKT1,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0030879	mammary gland development	3.1960317596419914e-8	3.1960317596419914e-8	+1	GATA3,ARHGAP35,TBX3,AKT1,ERBB4,ELF3,FGFR2,BRCA2
GO:0006259	DNA metabolic process	3.498257690678029e-8	3.498257690678029e-8	+1	TP53,EGFR,CDKN2A,DNMT3A,NPM1,AKT1,ATM,WT1,HGF,TET2,ATRX,BRCA1,POLQ,CHEK2,SETD2,EP300,USP9X,BRCA2,CDKN1A,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:0007059	chromosome segregation	3.8234908729014174e-8	3.8234908729014174e-8	+1	APC,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,BRCA1,PPP2R1A,SMC1A,SMC3,AXIN2,RAD21,ERCC2
GO:0042326	negative regulation of phosphorylation	3.8399741779133595e-8	3.8399741779133595e-8	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,LRRK2,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,NCOR1,CDKN2C
GO:0044087	regulation of cellular component biogenesis	3.902700897500691e-8	3.902700897500691e-8	+1	TP53,PIK3CA,PTEN,APC,NAV3,PIK3R1,RB1,NOTCH1,ARHGAP35,NPM1,RUNX1,EPHA3,AJUBA,ATM,TLR4,BRCA1,LRRK2,EP300,SMAD4,CBFB,ATR,PTPN11,MIR142,ERCC2
GO:0072331	signal transduction by p53 class mediator	4.376188007883382e-8	4.376188007883382e-8	+1	TP53,CDKN2A,STK11,AKT1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,TAF1,ATR,RPL5
GO:0043491	protein kinase B signaling	4.590480045308791e-8	4.590480045308791e-8	+1	PIK3CA,PTEN,EGFR,PIK3R1,GATA3,AKT1,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0051897	positive regulation of protein kinase B signaling	4.839802826697821e-8	4.839802826697821e-8	+1	PIK3CA,EGFR,PIK3R1,GATA3,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0031400	negative regulation of protein modification process	4.9973700567463964e-8	4.9973700567463964e-8	+1	PTEN,APC,NF1,CDKN2A,RB1,CTNNB1,NPM1,CEBPA,AKT1,CDKN1B,BRCA1,LRRK2,CDKN1A,TAF1,PPP2R1A,SIN3A,MAPK8IP1,RPL5
GO:0044085	cellular component biogenesis	5.0379353274446186e-8	5.0379353274446186e-8	+1	TP53,PIK3CA,PTEN,APC,NAV3,PIK3R1,CDKN2A,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,CTCF,NPM1,RUNX1,EPHA3,STAG2,AJUBA,EPPK1,SOX9,ATM,TLR4,ATRX,BRCA1,LRRK2,POLQ,CHEK2,KIT,PDGFRA,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,CBFB,ATR,HIST1H2BD,SMC1A,PTPN11,SMC3,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2
GO:0030330	DNA damage response, signal transduction by p53 class mediator	6.21374373179971e-8	6.21374373179971e-8	+1	TP53,CDKN2A,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,ATR
GO:0010948	negative regulation of cell cycle process	6.381843786296621e-8	6.381843786296621e-8	+1	TP53,PTEN,APC,CDKN2A,RB1,NPM1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,CDKN2C,EZH2
GO:0051241	negative regulation of multicellular organismal process	6.985499711593425e-8	6.985499711593425e-8	+1	PTEN,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,STK11,EPPK1,PIK3CG,SOX9,WT1,TLR4,FOXA1,PDGFRA,SMAD4,FOXA2,BRCA2,CBFB,PTPN11,MIR142
GO:0002520	immune system development	7.858686129838267e-8	7.858686129838267e-8	+1	TP53,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,TET2,POLQ,KIT,EP300,FGFR2,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A,MECOM
GO:0033673	negative regulation of kinase activity	8.37425062152523e-8	8.37425062152523e-8	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1
GO:0007063	regulation of sister chromatid cohesion	9.317898707939975e-8	9.317898707939975e-8	+1	RB1,CTNNB1,CTCF,ATRX,AXIN2,RAD21
GO:0030097	hemopoiesis	9.763713796435973e-8	9.763713796435973e-8	+1	TP53,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,TET2,KIT,EP300,FGFR2,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A,MECOM
GO:0032501	multicellular organismal process	9.766319813185351e-8	9.766319813185351e-8	+1	TP53,PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0045596	negative regulation of cell differentiation	1.0131500201665781e-7	1.0131500201665781e-7	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,RUNX1,TBX3,SOX9,TLR4,FOXA1,SMAD4,FOXA2,ASXL1,CBFB,PTPN11
GO:0000819	sister chromatid segregation	1.0695808191508401e-7	1.0695808191508401e-7	+1	APC,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0097190	apoptotic signaling pathway	1.1462949790979605e-7	1.1462949790979605e-7	+1	TP53,PTEN,RB1,FBXW7,NFE2L2,STK11,AKT1,AR,ATM,HGF,TLR4,BRCA1,LRRK2,CHEK2,EP300,FGFR3,CDKN1A,ACVR1B
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	1.2205984610047814e-7	1.2205984610047814e-7	+1	PIK3CA,PTEN,EGFR,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0050821	protein stabilization	1.2713248869670514e-7	1.2713248869670514e-7	+1	PTEN,VHL,PIK3R1,CDKN2A,FBXW7,CHEK2,EP300,USP9X,SOX17,CDKN1A,TAF1,RPL5
GO:0034968	histone lysine methylation	1.2893289356829136e-7	1.2893289356829136e-7	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0048534	hematopoietic or lymphoid organ development	1.3731065851709157e-7	1.3731065851709157e-7	+1	TP53,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,TET2,KIT,EP300,FGFR2,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A,MECOM
GO:0016570	histone modification	1.5452921594321974e-7	1.5452921594321974e-7	+1	CTNNB1,BAP1,KDM6A,KDM5C,TET2,ATRX,BRCA1,SETD2,EP300,SMAD4,BRCA2,ASXL1,SIN3A,NSD1,TBL1XR1,EZH2
GO:0045936	negative regulation of phosphate metabolic process	1.700429394326313e-7	1.700429394326313e-7	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,LRRK2,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,NCOR1,CDKN2C
GO:0031647	regulation of protein stability	1.7302682621562238e-7	1.7302682621562238e-7	+1	PTEN,VHL,KRAS,PIK3R1,CDKN2A,FBXW7,LRRK2,CHEK2,EP300,USP9X,SOX17,CDKN1A,TAF1,RPL5
GO:0010563	negative regulation of phosphorus metabolic process	1.7462298225070156e-7	1.7462298225070156e-7	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,LRRK2,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,NCOR1,CDKN2C
GO:0033043	regulation of organelle organization	1.7900083551195716e-7	1.7900083551195716e-7	+1	TP53,PIK3CA,APC,NAV3,PIK3R1,RB1,FBXW7,CTNNB1,ARHGAP35,CTCF,NPM1,EPHA3,AKT1,ATM,HGF,MTOR,ATRX,BRCA1,LRRK2,PDGFRA,EP300,SMAD4,ATR,SIN3A,AXIN2,RAD21
GO:2000677	regulation of transcription regulatory region DNA binding	2.2011103268990774e-7	2.2011103268990774e-7	+1	GATA3,RB1,CTNNB1,EP300,TAF1,SIN3A,NSD1
GO:0071901	negative regulation of protein serine/threonine kinase activity	2.2829009200397066e-7	2.2829009200397066e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,CEBPA,AKT1,CDKN1B,PPP2R1A,MAPK8IP1
GO:0009416	response to light stimulus	2.355137717824576e-7	2.355137717824576e-7	+1	TP53,EGFR,NF1,FBXW7,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
GO:0009894	regulation of catabolic process	2.3675347612760407e-7	2.3675347612760407e-7	+1	TP53,PIK3CA,PTEN,APC,EGFR,CDKN2A,FBXW7,KEAP1,NFE2L2,NPM1,STK11,CEBPA,AKT1,ATM,CDKN1B,HGF,MTOR,LRRK2,CHEK2,EP300,TAF1,NCOR1,RPL5,AXIN2
GO:0016569	covalent chromatin modification	2.4133758170686416e-7	2.4133758170686416e-7	+1	CTNNB1,BAP1,KDM6A,KDM5C,TET2,ATRX,BRCA1,SETD2,EP300,SMAD4,BRCA2,ASXL1,SIN3A,NSD1,TBL1XR1,EZH2
GO:0043410	positive regulation of MAPK cascade	2.5452998451516685e-7	2.5452998451516685e-7	+1	EGFR,NOTCH1,FBXW7,FLT3,MAP2K4,BRAF,PIK3CG,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,FGFR3,PTPN11,MAPK8IP1,EZH2
GO:1904030	negative regulation of cyclin-dependent protein kinase activity	2.7317918537673185e-7	2.7317918537673185e-7	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B,CDKN1A
GO:0006469	negative regulation of protein kinase activity	2.7317918537673185e-7	2.7317918537673185e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,CDKN1A,PPP2R1A,MAPK8IP1
GO:0090399	replicative senescence	3.0816698268376586e-7	3.0816698268376586e-7	+1	TP53,CDKN2A,ATM,CHEK2,ATR
GO:0070647	protein modification by small protein conjugation or removal	3.0816698268376586e-7	3.0816698268376586e-7	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,CTNNB1,KEAP1,NFE2L2,BAP1,AKT1,AR,BRCA1,LRRK2,EP300,SMAD4,USP9X,ASXL1,TAF1,CBFB,HIST1H2BD,RPL5,SMAD2,SPOP
GO:0048589	developmental growth	3.3435715895717174e-7	3.3435715895717174e-7	+1	PTEN,NOTCH1,CTNNB1,RUNX1,EPPK1,SOX9,CDKN1B,WT1,ERBB4,FGFR2,USP9X,FGFR3,CDKN1A,SIN3A
GO:0014070	response to organic cyclic compound	3.5623403332362776e-7	3.5623403332362776e-7	+1	ARID1A,EGFR,CTNNB1,CDH1,NPM1,RUNX1,AR,WT1,BRCA1,LRRK2,FOXA1,EP300,TGFBR2,TAF1,CBFB,NCOR1,SMAD2
GO:2000026	regulation of multicellular organismal development	4.004531904965417e-7	4.004531904965417e-7	+1	PTEN,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,RUNX1,SOX9,WT1,ERBB4,MTOR,TLR4,BRCA1,EP300,FGFR2,FOXA2,TGFBR2,SOX17,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,MIR142
GO:0042770	signal transduction in response to DNA damage	4.048752575483649e-7	4.048752575483649e-7	+1	TP53,CDKN2A,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,ATR
GO:0043086	negative regulation of catalytic activity	4.1131830772092367e-7	4.1131830772092367e-7	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NOTCH1,NPM1,CEBPA,AKT1,CDKN1B,HGF,LRRK2,FOXA2,CDKN1A,PPP2R1A,EIF4A2,MAPK8IP1,RPL5
GO:0033993	response to lipid	4.1976532155912007e-7	4.1976532155912007e-7	+1	ARID1A,EGFR,CTNNB1,RUNX1,EPHA3,AR,SOX9,ATM,TLR4,BRCA1,FOXA1,EP300,ASXL1,TGFBR2,CBFB,NCOR1,SMAD2,MIR142
GO:1901701	cellular response to oxygen-containing compound	4.780237264983619e-7	4.780237264983619e-7	+1	TP53,PIK3CA,APC,EGFR,PIK3R1,CTNNB1,CDH1,NFE2L2,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,PDGFRA,FOXA2,TAF1,PTPN11
GO:1901796	regulation of signal transduction by p53 class mediator	4.846150511687334e-7	4.846150511687334e-7	+1	TP53,CDKN2A,STK11,AKT1,ATM,BRCA1,CHEK2,EP300,TAF1,ATR,RPL5
GO:1901990	regulation of mitotic cell cycle phase transition	5.124818670931306e-7	5.124818670931306e-7	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,PPP2R1A,ERCC2,CDKN2C
GO:0030155	regulation of cell adhesion	5.891472780518522e-7	5.891472780518522e-7	+1	PIK3CA,PTEN,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,CDH1,RUNX1,EPHA3,AKT1,PIK3CG,ATM,FOXA1,FOXA2,TGFBR2,PPP2R1A,CBFB,PTPN11
GO:0018022	peptidyl-lysine methylation	5.987431680891356e-7	5.987431680891356e-7	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0071407	cellular response to organic cyclic compound	6.213272483364187e-7	6.213272483364187e-7	+1	ARID1A,EGFR,CTNNB1,CDH1,NPM1,RUNX1,AR,WT1,BRCA1,LRRK2,FOXA1,EP300,TAF1,CBFB,NCOR1
GO:0018108	peptidyl-tyrosine phosphorylation	6.216197347868265e-7	6.216197347868265e-7	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
GO:1901988	negative regulation of cell cycle phase transition	6.776054646594516e-7	6.776054646594516e-7	+1	TP53,PTEN,APC,CDKN2A,RB1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0018212	peptidyl-tyrosine modification	7.060358696529423e-7	7.060358696529423e-7	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
GO:0045860	positive regulation of protein kinase activity	8.210141829935033e-7	8.210141829935033e-7	+1	EGFR,FBXW7,FLT3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,MTOR,TLR4,LRRK2,KIT,CCND1,TGFBR2,CDKN1A,EZH2
GO:0043550	regulation of lipid kinase activity	8.449834522537562e-7	8.449834522537562e-7	+1	PIK3R1,RB1,FLT3,ERBB4,KIT,PDGFRA,FGFR3
GO:0051129	negative regulation of cellular component organization	9.395285177363637e-7	9.395285177363637e-7	+1	PIK3CA,PTEN,APC,NAV3,PIK3R1,NOTCH1,NPM1,EPHA3,AKT1,AR,ATM,HGF,ATRX,BRCA1,LRRK2,EP300,SMAD4,SIN3A,MIR142
GO:0070371	ERK1 and ERK2 cascade	9.462065219606808e-7	9.462065219606808e-7	+1	PTEN,EGFR,NOTCH1,FBXW7,BRAF,SOX9,ERBB4,TLR4,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
GO:0016571	histone methylation	9.617412915020455e-7	9.617412915020455e-7	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0044772	mitotic cell cycle phase transition	0.0000010100185582961823	0.0000010100185582961823	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,AKT1,AJUBA,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,PPP2R1A,ACVR1B,ERCC2,CDKN2C
GO:0007346	regulation of mitotic cell cycle	0.0000010626360097952137	0.0000010626360097952137	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,CTNNB1,AKT1,ATM,CDKN1B,FOXA1,CHEK2,EP300,CCND1,CDKN1A,PPP2R1A,ERCC2,CDKN2C
GO:0071156	regulation of cell cycle arrest	0.0000012111962797332337	0.0000012111962797332337	+1	TP53,CDKN2A,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	0.0000012220276457700263	0.0000012220276457700263	+1	PIK3CA,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0048511	rhythmic process	0.0000012875140421621298	0.0000012875140421621298	+1	TP53,PTEN,FBXW7,MTOR,PDGFRA,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:0048638	regulation of developmental growth	0.0000012875140421621298	0.0000012875140421621298	+1	PTEN,NOTCH1,RUNX1,EPPK1,CDKN1B,WT1,ERBB4,FGFR2,FGFR3,CDKN1A,SIN3A
GO:0034644	cellular response to UV	0.0000013363948858697809	0.0000013363948858697809	+1	TP53,FBXW7,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0016579	protein deubiquitination	0.000001400398569591253	0.000001400398569591253	+1	TP53,PTEN,APC,GATA3,KEAP1,BAP1,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,SMAD2
GO:1901699	cellular response to nitrogen compound	0.0000017299423453263028	0.0000017299423453263028	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,NPM1,AKT1,SOX9,WT1,MTOR,TLR4,ATRX,BRCA1,LRRK2,TAF1,PTPN11
GO:0071158	positive regulation of cell cycle arrest	0.000001768884808850898	0.000001768884808850898	+1	TP53,CDKN2A,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0007399	nervous system development	0.0000018254662108350116	0.0000018254662108350116	+1	PIK3CA,PTEN,APC,NAV3,NF1,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,SOX9,PRX,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,TGFBR2,TAF1,SIN3A,PTPN11,ACVR1B,MIR142,ERCC2
GO:0065008	regulation of biological quality	0.0000018681919546735149	0.0000018681919546735149	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,FLT3,TSHZ3,KEAP1,ARHGAP35,NFE2L2,NPM1,TBX3,STK11,CEBPA,AKT1,PIK3CG,SOX9,ATM,ERBB4,MTOR,TLR4,ATRX,LRRK2,CHEK2,KIT,PDGFRA,EP300,SMAD4,FOXA2,USP9X,SOX17,CDKN1A,TAF1,ATR,SIN3A,PTPN11,ACVR1B,ACVR2A,RPL5,AXIN2,MIR142
GO:0098813	nuclear chromosome segregation	0.0000020781158704448043	0.0000020781158704448043	+1	APC,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0048863	stem cell differentiation	0.000002240496954983941	0.000002240496954983941	+1	TP53,GATA3,NOTCH1,RUNX1,SOX9,ERBB4,KIT,SETD2,PDGFRA,FGFR2,CBFB
GO:0007569	cell aging	0.0000023000251373040086	0.0000023000251373040086	+1	TP53,CDKN2A,NPM1,TBX3,ATM,CHEK2,CDKN1A,ATR
GO:1901991	negative regulation of mitotic cell cycle phase transition	0.0000023518657477828666	0.0000023518657477828666	+1	TP53,PTEN,APC,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:1903827	regulation of cellular protein localization	0.000002458579391837423	0.000002458579391837423	+1	TP53,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,AR,LRRK2,SETD2,SIN3A
GO:0035265	organ growth	0.000002485932366608277	0.000002485932366608277	+1	PTEN,NOTCH1,RUNX1,SOX9,WT1,ERBB4,FGFR2,FGFR3
GO:0034502	protein localization to chromosome	0.000002485932366608277	0.000002485932366608277	+1	RB1,CTCF,ATM,ATRX,SETD2,BRCA2,ATR,RAD21
GO:0051240	positive regulation of multicellular organismal process	0.000002580338053526307	0.000002580338053526307	+1	APC,GATA3,NOTCH1,CTNNB1,RUNX1,SOX9,WT1,ERBB4,MTOR,TLR4,BRCA1,SETD2,EP300,FGFR2,SMAD4,FOXA2,TGFBR2,CBFB,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0001933	negative regulation of protein phosphorylation	0.0000026474897521296936	0.0000026474897521296936	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CEBPA,AKT1,CDKN1B,LRRK2,CDKN1A,PPP2R1A,MAPK8IP1
GO:0071478	cellular response to radiation	0.000002734120029965608	0.000002734120029965608	+1	TP53,GATA3,FBXW7,NPM1,STK11,ATM,EP300,CDKN1A,TAF1,ATR
GO:0070646	protein modification by small protein removal	0.000002734120029965608	0.000002734120029965608	+1	TP53,PTEN,APC,GATA3,KEAP1,BAP1,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,SMAD2
GO:0033365	protein localization to organelle	0.0000027401093300931414	0.0000027401093300931414	+1	TP53,APC,PIK3R1,CDKN2A,RB1,FBXW7,CDH1,CTCF,BAP1,IDH1,RPL22,AKT1,ATM,ATRX,LRRK2,SETD2,USP9X,BRCA2,ATR,SIN3A,RPL5,RAD21
GO:0033044	regulation of chromosome organization	0.00000284315983250008	0.00000284315983250008	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,BRCA1,SMAD4,ATR,SIN3A,AXIN2,RAD21
GO:0007568	aging	0.0000029499638993791003	0.0000029499638993791003	+1	TP53,CDKN2A,NPM1,TBX3,ATM,LRRK2,CHEK2,CDKN1A,ATR
GO:0044092	negative regulation of molecular function	0.0000031116693340018725	0.0000031116693340018725	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NOTCH1,KEAP1,NPM1,CEBPA,AKT1,CDKN1B,HGF,LRRK2,FOXA2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,MAPK8IP1,RPL5
GO:0030099	myeloid cell differentiation	0.0000032359306275499015	0.0000032359306275499015	+1	FBXW7,RUNX1,CEBPA,MTOR,TLR4,TET2,KIT,EP300,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A
GO:0051090	regulation of DNA-binding transcription factor activity	0.0000032359306275499015	0.0000032359306275499015	+1	PTEN,CDKN2A,RB1,CTNNB1,KEAP1,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,FOXA2,TAF1
GO:0048729	tissue morphogenesis	0.0000032359306275499015	0.0000032359306275499015	+1	PTEN,GATA3,NOTCH1,CTNNB1,ARHGAP35,TBX3,SOX9,WT1,HGF,MTOR,FGFR2,SMAD4,TGFBR2,SOX17,SMAD2
GO:0070372	regulation of ERK1 and ERK2 cascade	0.0000035987378821097076	0.0000035987378821097076	+1	PTEN,EGFR,NOTCH1,FBXW7,BRAF,ERBB4,TLR4,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
GO:0045930	negative regulation of mitotic cell cycle	0.0000035987378821097076	0.0000035987378821097076	+1	TP53,PTEN,APC,CDKN2A,RB1,CTNNB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0034097	response to cytokine	0.000003675484923492983	0.000003675484923492983	+1	TP53,PIK3CA,PIK3R1,GATA3,FLT3,NFE2L2,RUNX1,CEBPA,AKT1,SOX9,HGF,TLR4,BRCA1,KIT,SETD2,CCND1,SMAD4,FOXA2,CDKN1A,CBFB,PTPN11,LIFR,MIR142
GO:0060429	epithelium development	0.000003692184317545395	0.000003692184317545395	+1	PTEN,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,TBX3,AKT1,EPPK1,SOX9,WT1,HGF,ERBB4,MTOR,FGFR2,SMAD4,BRCA2,TGFBR2,SOX17,CBFB,VEZF1,ERCC2
GO:0061026	cardiac muscle tissue regeneration	0.0000037189697181336986	0.0000037189697181336986	+1	RUNX1,CDKN1B,ERBB4,CDKN1A
GO:0043551	regulation of phosphatidylinositol 3-kinase activity	0.000003826880235949753	0.000003826880235949753	+1	PIK3R1,FLT3,ERBB4,KIT,PDGFRA,FGFR3
GO:0060341	regulation of cellular localization	0.00000384271901767778	0.00000384271901767778	+1	TP53,PTEN,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,CDH1,BAP1,STK11,EPHA3,AKT1,AR,LRRK2,SETD2,FOXA2,SIN3A
GO:0007623	circadian rhythm	0.000003886982510307114	0.000003886982510307114	+1	TP53,PTEN,FBXW7,MTOR,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:0043405	regulation of MAP kinase activity	0.000003984423910550755	0.000003984423910550755	+1	EGFR,NF1,FLT3,MAP2K4,PIK3CG,TLR4,LRRK2,KIT,PPP2R1A,CDK12,MAPK8IP1,EZH2
GO:0009790	embryo development	0.0000043892357545545	0.0000043892357545545	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,WT1,ERBB4,BRCA1,KIT,SETD2,PDGFRA,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0043085	positive regulation of catalytic activity	0.0000043948028700711265	0.0000043948028700711265	+1	PTEN,EGFR,NF1,CDKN2A,FBXW7,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,PIK3CG,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,EZH2
GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	0.000004608894474820887	0.000004608894474820887	+1	PTEN,APC,EGFR,GATA3,CTNNB1,RUNX1,STK11,AKT1,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,TBL1XR1,AXIN2
GO:0031571	mitotic G1 DNA damage checkpoint	0.000004659134468975382	0.000004659134468975382	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0009725	response to hormone	0.000004967919210587469	0.000004967919210587469	+1	PIK3CA,APC,ARID1A,PIK3R1,GATA3,NOTCH1,RUNX1,AKT1,AR,WT1,BRCA1,FOXA1,EP300,CCND1,CBFB,PTPN11,NCOR1
GO:0044819	mitotic G1/S transition checkpoint	0.000005135835847205932	0.000005135835847205932	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0044783	G1 DNA damage checkpoint	0.000005135835847205932	0.000005135835847205932	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0051054	positive regulation of DNA metabolic process	0.000005836244008323118	0.000005836244008323118	+1	EGFR,AKT1,ATM,WT1,HGF,ATRX,BRCA1,USP9X,ATR,ERCC2
GO:0051130	positive regulation of cellular component organization	0.000006084493057964281	0.000006084493057964281	+1	TP53,PIK3CA,APC,NAV3,PIK3R1,RB1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AR,AJUBA,ATM,TLR4,ATRX,BRCA1,EP300,SMAD4,ATR,SIN3A,RAD21,ERCC2
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	0.000006084493057964281	0.000006084493057964281	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B
GO:0018205	peptidyl-lysine modification	0.000006298083475091109	0.000006298083475091109	+1	CDKN2A,CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,EP300,SMAD4,BRCA2,SIN3A,NSD1,EZH2
GO:0016055	Wnt signaling pathway	0.0000063920098721225125	0.0000063920098721225125	+1	PTEN,APC,EGFR,GATA3,CTNNB1,RUNX1,STK11,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,TBL1XR1,AXIN2
GO:0038127	ERBB signaling pathway	0.000006425317210145972	0.000006425317210145972	+1	PIK3CA,EGFR,PIK3R1,FBXW7,AKT1,BRAF,SOX9,ERBB4,PTPN11
GO:0198738	cell-cell signaling by wnt	0.000007124401480338455	0.000007124401480338455	+1	PTEN,APC,EGFR,GATA3,CTNNB1,RUNX1,STK11,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,TBL1XR1,AXIN2
GO:0062197	cellular response to chemical stress	0.000007510450894895851	0.000007510450894895851	+1	TP53,PIK3CA,EGFR,FBXW7,KEAP1,NFE2L2,AKT1,ATM,HGF,TLR4,LRRK2,PDGFRA
GO:0042176	regulation of protein catabolic process	0.000007638496089570738	0.000007638496089570738	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,LRRK2,CHEK2,TAF1,RPL5
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	0.000007639333893991661	0.000007639333893991661	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:0006479	protein methylation	0.00000806988039518468	0.00000806988039518468	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0008213	protein alkylation	0.00000806988039518468	0.00000806988039518468	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0000077	DNA damage checkpoint	0.000008544884864706652	0.000008544884864706652	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0006352	DNA-templated transcription, initiation	0.000009098679158388204	0.000009098679158388204	+1	TP53,PTEN,NOTCH1,CTNNB1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
GO:0001501	skeletal system development	0.000009244425185797828	0.000009244425185797828	+1	TP53,FBXW7,CTNNB1,RUNX1,TBX3,SOX9,KIT,PDGFRA,FGFR2,FGFR3,TGFBR2,PTPN11
GO:0030518	intracellular steroid hormone receptor signaling pathway	0.000009380112865982727	0.000009380112865982727	+1	ARID1A,RUNX1,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0071417	cellular response to organonitrogen compound	0.00000940555461502141	0.00000940555461502141	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,AKT1,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,TAF1,PTPN11
GO:0030111	regulation of Wnt signaling pathway	0.00000940555461502141	0.00000940555461502141	+1	APC,EGFR,CTNNB1,RUNX1,STK11,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,TBL1XR1,AXIN2
GO:0002009	morphogenesis of an epithelium	0.00000940555461502141	0.00000940555461502141	+1	PTEN,GATA3,NOTCH1,CTNNB1,ARHGAP35,TBX3,SOX9,WT1,HGF,MTOR,FGFR2,TGFBR2,SOX17
GO:0032870	cellular response to hormone stimulus	0.00001065380304671895	0.00001065380304671895	+1	PIK3CA,APC,ARID1A,PIK3R1,NOTCH1,RUNX1,AKT1,AR,WT1,BRCA1,FOXA1,EP300,CBFB,PTPN11,NCOR1
GO:0072422	signal transduction involved in DNA damage checkpoint	0.00001065380304671895	0.00001065380304671895	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0072401	signal transduction involved in DNA integrity checkpoint	0.00001065380304671895	0.00001065380304671895	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.000010775990230321693	0.000010775990230321693	+1	PIK3CA,APC,EGFR,PIK3R1,GATA3,FBXW7,FLT3,EPHA3,AKT1,BRAF,SOX9,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0001656	metanephros development	0.00001090366155891318	0.00001090366155891318	+1	NF1,GATA3,SOX9,WT1,PDGFRA,SOX17
GO:0061180	mammary gland epithelium development	0.000010990315573574608	0.000010990315573574608	+1	GATA3,AKT1,ERBB4,FGFR2,BRCA2
GO:0001822	kidney development	0.000011048784381124814	0.000011048784381124814	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:0097193	intrinsic apoptotic signaling pathway	0.000011776234183918502	0.000011776234183918502	+1	TP53,FBXW7,NFE2L2,STK11,AKT1,ATM,BRCA1,LRRK2,CHEK2,EP300,CDKN1A
GO:0006367	transcription initiation from RNA polymerase II promoter	0.000012043918358021305	0.000012043918358021305	+1	TP53,PTEN,NOTCH1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
GO:0043401	steroid hormone mediated signaling pathway	0.000012043918358021305	0.000012043918358021305	+1	ARID1A,RUNX1,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0016477	cell migration	0.000012992682346856518	0.000012992682346856518	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0072395	signal transduction involved in cell cycle checkpoint	0.000013628846330324592	0.000013628846330324592	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0003179	heart valve morphogenesis	0.000013735394751967122	0.000013735394751967122	+1	GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2
GO:0050678	regulation of epithelial cell proliferation	0.00001413571468839615	0.00001413571468839615	+1	EGFR,NF1,GATA3,FBXW7,NRAS,AKT1,EPPK1,SOX9,TLR4,FGFR2,BRCA2,EGR3
GO:0051091	positive regulation of DNA-binding transcription factor activity	0.000014169093605096926	0.000014169093605096926	+1	PTEN,CTNNB1,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,TAF1
GO:0072001	renal system development	0.000014257959277633201	0.000014257959277633201	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:0031570	DNA integrity checkpoint	0.000014257959277633201	0.000014257959277633201	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0022008	neurogenesis	0.000014395311046207588	0.000014395311046207588	+1	PIK3CA,PTEN,NF1,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,PRX,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,SIN3A,PTPN11,MIR142,ERCC2
GO:0010639	negative regulation of organelle organization	0.000014452314130063468	0.000014452314130063468	+1	PIK3CA,APC,NAV3,PIK3R1,NPM1,AKT1,ATM,HGF,ATRX,BRCA1,LRRK2,SMAD4
GO:0001763	morphogenesis of a branching structure	0.000014571618848914799	0.000014571618848914799	+1	CTNNB1,SOX9,WT1,HGF,LRRK2,FGFR2,TGFBR2
GO:1902532	negative regulation of intracellular signal transduction	0.00001474787969711664	0.00001474787969711664	+1	PTEN,NF1,ARHGAP35,NFE2L2,STK11,AKT1,AJUBA,ATM,TLR4,LRRK2,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0070602	regulation of centromeric sister chromatid cohesion	0.000015021816850542111	0.000015021816850542111	+1	CTNNB1,CTCF,AXIN2
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	0.00001551397169352577	0.00001551397169352577	+1	FLT3,ERBB4,KIT,PDGFRA,FGFR3
GO:0001667	ameboidal-type cell migration	0.000015583347225495812	0.000015583347225495812	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,PIK3CG,SOX9,ERBB4,MTOR,KIT,ACVR1B,EGR3
GO:0000075	cell cycle checkpoint	0.000016031747418686027	0.000016031747418686027	+1	TP53,APC,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0061458	reproductive system development	0.00001636612444025367	0.00001636612444025367	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
GO:0048608	reproductive structure development	0.00001636612444025367	0.00001636612444025367	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
GO:0030520	intracellular estrogen receptor signaling pathway	0.000016766457413325788	0.000016766457413325788	+1	ARID1A,RUNX1,AR,BRCA1,FOXA1,CBFB
GO:0048699	generation of neurons	0.000016766457413325788	0.000016766457413325788	+1	PIK3CA,PTEN,NF1,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,SIN3A,PTPN11,MIR142,ERCC2
GO:0007173	epidermal growth factor receptor signaling pathway	0.000017170238121341052	0.000017170238121341052	+1	PIK3CA,EGFR,PIK3R1,FBXW7,AKT1,BRAF,SOX9,PTPN11
GO:0019216	regulation of lipid metabolic process	0.000017539361931293576	0.000017539361931293576	+1	FBXW7,FLT3,AKT1,SOX9,ERBB4,MTOR,BRCA1,KIT,PDGFRA,FGFR3,SIN3A,TBL1XR1,NCOR1
GO:0043414	macromolecule methylation	0.00001788496928417009	0.00001788496928417009	+1	CTNNB1,DNMT3A,KDM6A,WT1,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0045165	cell fate commitment	0.00001794305947200758	0.00001794305947200758	+1	APC,GATA3,TBX3,SOX9,WT1,FGFR2,FOXA2,SOX17,SMAD2
GO:0048568	embryonic organ development	0.000017948391728524803	0.000017948391728524803	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,KIT,PDGFRA,FGFR2,TGFBR2,SOX17
GO:0006338	chromatin remodeling	0.000018723689808477666	0.000018723689808477666	+1	ARID1A,PBRM1,CDKN2A,RB1,NPM1,KDM6A,SOX9,KDM5C,ATRX,FOXA1
GO:0022407	regulation of cell-cell adhesion	0.00001899004906023217	0.00001899004906023217	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,NOTCH1,CDH1,RUNX1,AKT1,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:0098609	cell-cell adhesion	0.000019801605695393535	0.000019801605695393535	+1	PIK3CA,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,RUNX1,AKT1,PIK3CG,FOXA1,KIT,PDGFRA,FOXA2,TGFBR2,CBFB,PTPN11
GO:0031329	regulation of cellular catabolic process	0.000019961403589124584	0.000019961403589124584	+1	TP53,PIK3CA,PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,NPM1,STK11,CEBPA,AKT1,ATM,HGF,MTOR,LRRK2,EP300,TAF1,RPL5,AXIN2
GO:0060070	canonical Wnt signaling pathway	0.00002008514461628109	0.00002008514461628109	+1	PTEN,APC,EGFR,GATA3,CTNNB1,STK11,SOX9,LRRK2,FGFR2,SOX17,TBL1XR1,AXIN2
GO:0007548	sex differentiation	0.000020340799249076453	0.000020340799249076453	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,PTPN11
GO:0043276	anoikis	0.000021242508442279413	0.000021242508442279413	+1	PIK3CA,NOTCH1,STK11,AKT1,MTOR
GO:0071482	cellular response to light stimulus	0.000021570529660229208	0.000021570529660229208	+1	TP53,FBXW7,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0048598	embryonic morphogenesis	0.000022689044805117216	0.000022689044805117216	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,SETD2,PDGFRA,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0001655	urogenital system development	0.000022689044805117216	0.000022689044805117216	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:0003170	heart valve development	0.000022696677843728092	0.000022696677843728092	+1	GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2
GO:0071824	protein-DNA complex subunit organization	0.000024341298049461708	0.000024341298049461708	+1	TP53,ARID1A,RB1,CTCF,NPM1,SOX9,ATRX,SETD2,TAF1,HIST1H2BD,ERCC2
GO:0022612	gland morphogenesis	0.00002475192564731563	0.00002475192564731563	+1	FBXW7,SOX9,HGF,ELF3,FGFR2
GO:0006281	DNA repair	0.00002475192564731563	0.00002475192564731563	+1	TP53,EGFR,NPM1,ATM,BRCA1,POLQ,CHEK2,SETD2,EP300,BRCA2,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:0003151	outflow tract morphogenesis	0.000025080977436820518	0.000025080977436820518	+1	NOTCH1,CTNNB1,FGFR2,SMAD4,TGFBR2,SOX17
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	0.000026700766553880974	0.000026700766553880974	+1	TP53,EGFR,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PPP2R1A,PTPN11
GO:0007155	cell adhesion	0.00002727241816512689	0.00002727241816512689	+1	PIK3CA,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,RUNX1,EPHA3,AKT1,PIK3CG,ATM,FOXA1,KIT,PDGFRA,FOXA2,TGFBR2,PPP2R1A,CBFB,PTPN11
GO:0051101	regulation of DNA binding	0.00002819833301154093	0.00002819833301154093	+1	GATA3,RB1,CTNNB1,EP300,TAF1,SIN3A,NSD1
GO:0033002	muscle cell proliferation	0.000028555020058014186	0.000028555020058014186	+1	PTEN,NOTCH1,CTNNB1,RUNX1,AKT1,CDKN1B,ERBB4,FGFR2,CDKN1A
GO:0090218	positive regulation of lipid kinase activity	0.000028651272586932847	0.000028651272586932847	+1	FLT3,ERBB4,KIT,PDGFRA,FGFR3
GO:1903706	regulation of hemopoiesis	0.000028651272586932847	0.000028651272586932847	+1	CDKN2A,GATA3,FBXW7,RUNX1,MTOR,TLR4,EP300,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A
GO:0006508	proteolysis	0.000028651272586932847	0.000028651272586932847	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,CTNNB1,KEAP1,NFE2L2,BAP1,RUNX1,CEBPA,AKT1,AR,HGF,BRCA1,LRRK2,EP300,SMAD4,USP9X,ASXL1,TAF1,TBL1XR1,RPL5,SMAD2,SPOP
GO:0034613	cellular protein localization	0.000029037257280247613	0.000029037257280247613	+1	TP53,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,IDH1,RPL22,EPHA3,AKT1,BRAF,AR,ATM,U2AF1,ATRX,LRRK2,SETD2,USP9X,BRCA2,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:0022610	biological adhesion	0.00002969298955818948	0.00002969298955818948	+1	PIK3CA,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,RUNX1,EPHA3,AKT1,PIK3CG,ATM,FOXA1,KIT,PDGFRA,FOXA2,TGFBR2,PPP2R1A,CBFB,PTPN11
GO:0051098	regulation of binding	0.000030510264326826558	0.000030510264326826558	+1	GATA3,RB1,CTNNB1,AKT1,LRRK2,EP300,CDKN1A,TAF1,SIN3A,NSD1,SMAD2
GO:0060562	epithelial tube morphogenesis	0.00003098859667700505	0.00003098859667700505	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,WT1,FGFR2,TGFBR2,SOX17
GO:0009895	negative regulation of catabolic process	0.0000314820404699505	0.0000314820404699505	+1	PIK3CA,EGFR,CDKN2A,AKT1,HGF,MTOR,LRRK2,TAF1,NCOR1,RPL5,AXIN2
GO:0048468	cell development	0.00003187039977873783	0.00003187039977873783	+1	PIK3CA,PTEN,NF1,PIK3R1,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,WT1,PRX,ERBB4,LRRK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,SIN3A,PTPN11,MIR142
GO:0010212	response to ionizing radiation	0.00003193283431644148	0.00003193283431644148	+1	TP53,GATA3,STK11,ATM,BRCA1,CDKN1A,ATR
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	0.00003193283431644148	0.00003193283431644148	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0070727	cellular macromolecule localization	0.00003204534476856854	0.00003204534476856854	+1	TP53,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,IDH1,RPL22,EPHA3,AKT1,BRAF,AR,ATM,U2AF1,ATRX,LRRK2,SETD2,USP9X,BRCA2,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:0003007	heart morphogenesis	0.00003207982250137841	0.00003207982250137841	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,FGFR2,SMAD4,TGFBR2,SOX17
GO:0032259	methylation	0.00003217602851455248	0.00003217602851455248	+1	CTNNB1,DNMT3A,KDM6A,WT1,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0046620	regulation of organ growth	0.00003281032327230826	0.00003281032327230826	+1	PTEN,NOTCH1,RUNX1,WT1,ERBB4,FGFR2
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	0.00003281032327230826	0.00003281032327230826	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0032879	regulation of localization	0.00003291724877482473	0.00003291724877482473	+1	TP53,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,BAP1,STK11,EPHA3,AKT1,BRAF,AR,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,SETD2,PDGFRA,FOXA2,SIN3A,PTPN11,ACVR1B
GO:0018105	peptidyl-serine phosphorylation	0.000032958783377501524	0.000032958783377501524	+1	PTEN,EGFR,AKT1,BRAF,ATM,MTOR,LRRK2,TGFBR2,TAF1,ATR,NSD1
GO:0071681	cellular response to indole-3-methanol	0.000032958783377501524	0.000032958783377501524	+1	CTNNB1,CDH1,BRCA1
GO:0071680	response to indole-3-methanol	0.000032958783377501524	0.000032958783377501524	+1	CTNNB1,CDH1,BRCA1
GO:0010629	negative regulation of gene expression	0.000033214504183325587	0.000033214504183325587	+1	TP53,VHL,NAV3,EGFR,RB1,NOTCH1,FBXW7,DNMT3A,NPM1,RUNX1,RPL22,AKT1,AJUBA,ATM,TLR4,LRRK2,TAF1,PPP2R1A,SIN3A,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0050673	epithelial cell proliferation	0.00003425625111131519	0.00003425625111131519	+1	EGFR,NF1,GATA3,FBXW7,NRAS,AKT1,EPPK1,SOX9,TLR4,FGFR2,BRCA2,EGR3
GO:0071496	cellular response to external stimulus	0.00003493525881474542	0.00003493525881474542	+1	TP53,MAP3K1,ARHGAP35,MAP2K4,SOX9,MTOR,TLR4,LRRK2,FOXA2,CDKN1A
GO:0030522	intracellular receptor signaling pathway	0.00003493525881474542	0.00003493525881474542	+1	ARID1A,RUNX1,AR,BRCA1,FOXA1,EP300,ASXL1,CBFB,NCOR1,EZH2
GO:0032880	regulation of protein localization	0.000035155465251244334	0.000035155465251244334	+1	TP53,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,AR,TLR4,LRRK2,SETD2,FOXA2,SIN3A
GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint	0.00003531789481547096	0.00003531789481547096	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:1902400	intracellular signal transduction involved in G1 DNA damage checkpoint	0.00003531789481547096	0.00003531789481547096	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0002682	regulation of immune system process	0.00003531789481547096	0.00003531789481547096	+1	PIK3CA,KRAS,PIK3R1,CDKN2A,GATA3,FBXW7,MAP3K1,RUNX1,NRAS,MAP2K4,CEBPA,AKT1,SOX9,ATM,MTOR,TLR4,KIT,EP300,TGFBR2,CBFB,SIN3A,PTPN11,ACVR1B,MAPK8IP1,ACVR2A,MIR142
GO:0051248	negative regulation of protein metabolic process	0.00003531789481547096	0.00003531789481547096	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,CTNNB1,NPM1,CEBPA,AKT1,CDKN1B,HGF,BRCA1,LRRK2,CDKN1A,TAF1,PPP2R1A,SIN3A,MAPK8IP1,RPL5
GO:1901698	response to nitrogen compound	0.00003680913737081293	0.00003680913737081293	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,NFE2L2,NPM1,AKT1,SOX9,WT1,MTOR,TLR4,ATRX,BRCA1,LRRK2,TAF1,PTPN11
GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.00003809605788861499	0.00003809605788861499	+1	NOTCH1,STK11,EP300,SMAD4,ACVR1B,ACVR2A,SMAD2
GO:0030182	neuron differentiation	0.000041406963643957534	0.000041406963643957534	+1	PIK3CA,PTEN,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,SIN3A,PTPN11,ERCC2
GO:1902402	signal transduction involved in mitotic DNA damage checkpoint	0.00004245369522580385	0.00004245369522580385	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:1902403	signal transduction involved in mitotic DNA integrity checkpoint	0.00004245369522580385	0.00004245369522580385	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0050865	regulation of cell activation	0.00004287155936896252	0.00004287155936896252	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,CEBPA,AKT1,ATM,TLR4,PDGFRA,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:0071396	cellular response to lipid	0.00004602504822197722	0.00004602504822197722	+1	ARID1A,EGFR,RUNX1,EPHA3,AR,SOX9,ATM,TLR4,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0046661	male sex differentiation	0.0000464193843176499	0.0000464193843176499	+1	GATA3,TBX3,AR,SOX9,WT1,KIT
GO:0048562	embryonic organ morphogenesis	0.000046754063889660164	0.000046754063889660164	+1	NOTCH1,CTNNB1,TBX3,SOX9,PDGFRA,FGFR2,TGFBR2,SOX17
GO:0032269	negative regulation of cellular protein metabolic process	0.00004731315251938787	0.00004731315251938787	+1	PTEN,APC,NF1,CDKN2A,RB1,CTNNB1,NPM1,CEBPA,AKT1,CDKN1B,HGF,BRCA1,LRRK2,CDKN1A,TAF1,PPP2R1A,SIN3A,MAPK8IP1,RPL5
GO:0010631	epithelial cell migration	0.00004760706477901232	0.00004760706477901232	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,PIK3CG,SOX9,MTOR,KIT,EGR3
GO:0071383	cellular response to steroid hormone stimulus	0.00004908019204134088	0.00004908019204134088	+1	ARID1A,RUNX1,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0090132	epithelium migration	0.00005025687427080739	0.00005025687427080739	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,PIK3CG,SOX9,MTOR,KIT,EGR3
GO:0072413	signal transduction involved in mitotic cell cycle checkpoint	0.00005025687427080739	0.00005025687427080739	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0071345	cellular response to cytokine stimulus	0.00005025687427080739	0.00005025687427080739	+1	TP53,PIK3CA,PIK3R1,GATA3,FLT3,NFE2L2,RUNX1,CEBPA,AKT1,SOX9,HGF,TLR4,BRCA1,KIT,CCND1,SMAD4,CDKN1A,CBFB,PTPN11,LIFR
GO:0043933	protein-containing complex subunit organization	0.000050542421966773546	0.000050542421966773546	+1	TP53,PIK3CA,APC,ARID1A,NAV3,RB1,CTNNB1,CTCF,NPM1,AJUBA,SOX9,ATM,TLR4,ATRX,LRRK2,POLQ,SETD2,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,ATR,HIST1H2BD,PTPN11,RPL5,SMAD2,AXIN2,ERCC2
GO:0070374	positive regulation of ERK1 and ERK2 cascade	0.0000521654026164037	0.0000521654026164037	+1	EGFR,NOTCH1,FBXW7,BRAF,ERBB4,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0001944	vasculature development	0.000052626423473228645	0.000052626423473228645	+1	PIK3CA,NF1,NOTCH1,FBXW7,CTNNB1,RUNX1,STK11,AKT1,WT1,BRCA1,KIT,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0006260	DNA replication	0.00005303428162595841	0.00005303428162595841	+1	EGFR,ATM,ATRX,BRCA1,POLQ,CHEK2,BRCA2,PPP2R1A,ATR,SMC3
GO:0022409	positive regulation of cell-cell adhesion	0.00005303428162595841	0.00005303428162595841	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:0090130	tissue migration	0.000055703110997416375	0.000055703110997416375	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,PIK3CG,SOX9,MTOR,KIT,EGR3
GO:0018209	peptidyl-serine modification	0.0000569604179830601	0.0000569604179830601	+1	PTEN,EGFR,AKT1,BRAF,ATM,MTOR,LRRK2,TGFBR2,TAF1,ATR,NSD1
GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	0.000059319128031096615	0.000059319128031096615	+1	RUNX1,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0060956	endocardial cell differentiation	0.00006067043795015087	0.00006067043795015087	+1	NOTCH1,SMAD4,SOX17
GO:0032927	positive regulation of activin receptor signaling pathway	0.00006067043795015087	0.00006067043795015087	+1	ACVR1B,ACVR2A,SMAD2
GO:0003348	cardiac endothelial cell differentiation	0.00006067043795015087	0.00006067043795015087	+1	NOTCH1,SMAD4,SOX17
GO:0009880	embryonic pattern specification	0.00006112952315410062	0.00006112952315410062	+1	TBX3,WT1,ERBB4,FGFR2,SMAD2
GO:1903050	regulation of proteolysis involved in cellular protein catabolic process	0.00006355132249614367	0.00006355132249614367	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:1903201	regulation of oxidative stress-induced cell death	0.00006404798723039511	0.00006404798723039511	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0051674	localization of cell	0.00006586336766201704	0.00006586336766201704	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0048870	cell motility	0.00006586336766201704	0.00006586336766201704	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0044773	mitotic DNA damage checkpoint	0.00006646171556239277	0.00006646171556239277	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0007389	pattern specification process	0.00006708612188718822	0.00006708612188718822	+1	APC,NOTCH1,TBX3,WT1,ERBB4,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0071902	positive regulation of protein serine/threonine kinase activity	0.00007724158721011823	0.00007724158721011823	+1	EGFR,FLT3,MAP2K4,AKT1,PIK3CG,TLR4,LRRK2,KIT,CCND1,EZH2
GO:0030334	regulation of cell migration	0.00007724158721011823	0.00007724158721011823	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,KIT,PDGFRA,ACVR1B
GO:0034599	cellular response to oxidative stress	0.00007724158721011823	0.00007724158721011823	+1	TP53,EGFR,FBXW7,KEAP1,NFE2L2,AKT1,HGF,TLR4,LRRK2,PDGFRA
GO:0003281	ventricular septum development	0.00007757686805034786	0.00007757686805034786	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0040012	regulation of locomotion	0.00008009575399240052	0.00008009575399240052	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,ACVR1B
GO:0002694	regulation of leukocyte activation	0.00008097089083276184	0.00008097089083276184	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,CEBPA,AKT1,ATM,TLR4,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:0061138	morphogenesis of a branching epithelium	0.00008115387688892648	0.00008115387688892648	+1	CTNNB1,SOX9,WT1,HGF,FGFR2,TGFBR2
GO:2001252	positive regulation of chromosome organization	0.00008205614047910945	0.00008205614047910945	+1	CTNNB1,ATM,ATRX,BRCA1,SMAD4,ATR,SIN3A,RAD21
GO:0042110	T cell activation	0.00008205614047910945	0.00008205614047910945	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,PIK3CG,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0009612	response to mechanical stimulus	0.00008396553823940965	0.00008396553823940965	+1	PIK3CA,CTNNB1,MAP3K1,MAP2K4,SOX9,TLR4,KIT
GO:0042246	tissue regeneration	0.00008658574960844616	0.00008658574960844616	+1	RUNX1,EPPK1,CDKN1B,ERBB4,CDKN1A
GO:0009057	macromolecule catabolic process	0.00008903533284004108	0.00008903533284004108	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,RPL22,CEBPA,AKT1,ATM,CDKN1B,MTOR,LRRK2,CHEK2,USP9X,TAF1,PPP2R1A,TBL1XR1,RPL5,SPOP,AXIN2
GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process	0.00009429788936855445	0.00009429788936855445	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0044774	mitotic DNA integrity checkpoint	0.00009429788936855445	0.00009429788936855445	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0045732	positive regulation of protein catabolic process	0.00010086564021059793	0.00010086564021059793	+1	PTEN,APC,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,LRRK2,TAF1
GO:0051568	histone H3-K4 methylation	0.00010884329336652233	0.00010884329336652233	+1	CTNNB1,KDM6A,TET2,BRCA1,SMAD4
GO:0045637	regulation of myeloid cell differentiation	0.00010887306716364883	0.00010887306716364883	+1	FBXW7,RUNX1,MTOR,TLR4,EP300,CBFB,SIN3A,ACVR1B,ACVR2A
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	0.00011067803552212753	0.00011067803552212753	+1	NOTCH1,NFE2L2,EP300,SMAD4
GO:0007417	central nervous system development	0.00011073366678249346	0.00011073366678249346	+1	PTEN,NF1,NOTCH1,CTNNB1,ARHGAP35,TBX3,SOX9,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,SIN3A,PTPN11,MIR142
GO:0010243	response to organonitrogen compound	0.00011764836654737432	0.00011764836654737432	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,NFE2L2,AKT1,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,TAF1,PTPN11
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	0.00011824804546201845	0.00011824804546201845	+1	TP53,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PTPN11
GO:0002521	leukocyte differentiation	0.00012024444856059292	0.00012024444856059292	+1	CDKN2A,GATA3,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,KIT,TGFBR2,CBFB
GO:1903829	positive regulation of cellular protein localization	0.00012082786693503975	0.00012082786693503975	+1	TP53,APC,EGFR,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,EPHA3,AKT1
GO:0007093	mitotic cell cycle checkpoint	0.00012320470866261854	0.00012320470866261854	+1	TP53,APC,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0001503	ossification	0.0001244744618671283	0.0001244744618671283	+1	EGFR,NF1,NOTCH1,RUNX1,SOX9,HGF,FGFR2,FGFR3,PTPN11,ACVR2A
GO:1900407	regulation of cellular response to oxidative stress	0.0001266709484398398	0.0001266709484398398	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0043409	negative regulation of MAPK cascade	0.00012807391276869665	0.00012807391276869665	+1	PTEN,NF1,TLR4,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0009755	hormone-mediated signaling pathway	0.00012807391276869665	0.00012807391276869665	+1	ARID1A,RUNX1,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0035295	tube development	0.00012984580607727542	0.00012984580607727542	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,TBX3,CEBPA,AKT1,SOX9,WT1,BRCA1,KIT,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:2000679	positive regulation of transcription regulatory region DNA binding	0.00013107426124005003	0.00013107426124005003	+1	GATA3,RB1,CTNNB1,EP300
GO:0006359	regulation of transcription by RNA polymerase III	0.00013107426124005003	0.00013107426124005003	+1	CEBPA,AR,MTOR,BRCA1
GO:0051270	regulation of cellular component movement	0.00013154657336015015	0.00013154657336015015	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,STK11,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,KIT,PDGFRA,ACVR1B
GO:0007010	cytoskeleton organization	0.00013436801417828092	0.00013436801417828092	+1	PIK3CA,APC,NAV3,NF1,PIK3R1,CTNNB1,ARHGAP35,NPM1,EPHA3,STAG2,AJUBA,EPPK1,MTOR,BRCA1,CHEK2,KIT,SETD2,PDGFRA,SMAD4,BRCA2,SMC1A,SMC3,NCOR1
GO:0065003	protein-containing complex assembly	0.00013602496776111072	0.00013602496776111072	+1	TP53,APC,NAV3,RB1,CTNNB1,NPM1,AJUBA,SOX9,ATM,TLR4,ATRX,LRRK2,POLQ,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,ATR,HIST1H2BD,PTPN11,RPL5,SMAD2,AXIN2,ERCC2
GO:0008104	protein localization	0.00013602496776111072	0.00013602496776111072	+1	TP53,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,KEAP1,CDH1,CTCF,BAP1,NPM1,IDH1,RPL22,EPHA3,AKT1,BRAF,AR,ATM,TLR4,U2AF1,ATRX,LRRK2,SETD2,FOXA2,USP9X,BRCA2,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:0042060	wound healing	0.00013691592121908207	0.00013691592121908207	+1	PIK3CA,PTEN,NF1,PIK3R1,GATA3,ARHGAP35,EPPK1,PIK3CG,MTOR,TLR4,PDGFRA,FOXA2,PTPN11
GO:0051272	positive regulation of cellular component movement	0.00013926196562882403	0.00013926196562882403	+1	APC,EGFR,GATA3,NOTCH1,STK11,AKT1,PIK3CG,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:0072594	establishment of protein localization to organelle	0.00014202642631353738	0.00014202642631353738	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,IDH1,RPL22,AKT1,ATM,LRRK2,USP9X,BRCA2,ATR,RPL5
GO:1903320	regulation of protein modification by small protein conjugation or removal	0.00014244868092059537	0.00014244868092059537	+1	PTEN,CDKN2A,FBXW7,CTNNB1,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0050863	regulation of T cell activation	0.00014244868092059537	0.00014244868092059537	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0006979	response to oxidative stress	0.00014244868092059537	0.00014244868092059537	+1	TP53,EGFR,FBXW7,KEAP1,NFE2L2,AKT1,HGF,TLR4,LRRK2,PDGFRA,ERCC2
GO:0044839	cell cycle G2/M phase transition	0.00014691650910618188	0.00014691650910618188	+1	TP53,CDKN2A,NPM1,AJUBA,ATM,BRCA1,CHEK2,CCND1,CDKN1A,PPP2R1A
GO:0003157	endocardium development	0.00015188719137367878	0.00015188719137367878	+1	NOTCH1,SMAD4,SOX17
GO:0002244	hematopoietic progenitor cell differentiation	0.00016843475761456656	0.00016843475761456656	+1	TP53,GATA3,NOTCH1,FLT3,RUNX1,KIT,CBFB
GO:0030163	protein catabolic process	0.00016855497970329696	0.00016855497970329696	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,CDKN1B,MTOR,LRRK2,CHEK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:2000145	regulation of cell motility	0.0001753119037336344	0.0001753119037336344	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,KIT,PDGFRA,ACVR1B
GO:0071479	cellular response to ionizing radiation	0.00017600910746798113	0.00017600910746798113	+1	TP53,GATA3,ATM,CDKN1A,ATR
GO:0060828	regulation of canonical Wnt signaling pathway	0.00017600910746798113	0.00017600910746798113	+1	APC,EGFR,CTNNB1,STK11,SOX9,LRRK2,FGFR2,SOX17,TBL1XR1,AXIN2
GO:0048872	homeostasis of number of cells	0.00017600910746798113	0.00017600910746798113	+1	NOTCH1,FLT3,AKT1,SOX9,KIT,ACVR1B,ACVR2A
GO:0031060	regulation of histone methylation	0.00017600910746798113	0.00017600910746798113	+1	CTNNB1,ATRX,BRCA1,SMAD4,NSD1
GO:0007064	mitotic sister chromatid cohesion	0.00018115812309272574	0.00018115812309272574	+1	RB1,ATRX,SMC1A,RAD21
GO:0010942	positive regulation of cell death	0.00018220380043777097	0.00018220380043777097	+1	TP53,PTEN,APC,NF1,CDKN2A,NOTCH1,FBXW7,CTNNB1,ATM,CDKN1B,TLR4,LRRK2,FOXA1,AXIN2
GO:0007265	Ras protein signal transduction	0.00018605994628195818	0.00018605994628195818	+1	TP53,KRAS,NF1,CDKN2A,RB1,NOTCH1,ARHGAP35,NRAS,PIK3CG,CDKN1A
GO:1902882	regulation of response to oxidative stress	0.0001864087292952401	0.0001864087292952401	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:1903362	regulation of cellular protein catabolic process	0.0001864087292952401	0.0001864087292952401	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:0048545	response to steroid hormone	0.0001901223864281195	0.0001901223864281195	+1	ARID1A,RUNX1,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0048646	anatomical structure formation involved in morphogenesis	0.00019949387939056928	0.00019949387939056928	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,SOX9,WT1,BRCA1,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,TGFBR2,SOX17,EGR3,SMAD2
GO:2001233	regulation of apoptotic signaling pathway	0.00020890063610552091	0.00020890063610552091	+1	TP53,PTEN,RB1,FBXW7,NFE2L2,AKT1,AR,HGF,BRCA1,LRRK2
GO:0060688	regulation of morphogenesis of a branching structure	0.00021047970389570557	0.00021047970389570557	+1	SOX9,HGF,LRRK2,FGFR2
GO:0007622	rhythmic behavior	0.00021047970389570557	0.00021047970389570557	+1	TP53,PTEN,MTOR,NCOR1
GO:0048512	circadian behavior	0.00021047970389570557	0.00021047970389570557	+1	TP53,PTEN,MTOR,NCOR1
GO:0060420	regulation of heart growth	0.00021051997198661725	0.00021051997198661725	+1	NOTCH1,RUNX1,WT1,ERBB4,FGFR2
GO:0036473	cell death in response to oxidative stress	0.00021111842212189443	0.00021111842212189443	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0045475	locomotor rhythm	0.00021781580277153311	0.00021781580277153311	+1	PTEN,MTOR,NCOR1
GO:0140014	mitotic nuclear division	0.0002261692655804621	0.0002261692655804621	+1	APC,RB1,STAG2,ATM,ATRX,CHEK2,PPP2R1A,SMC1A,SMC3,RAD21
GO:0001708	cell fate specification	0.00023036645958083085	0.00023036645958083085	+1	APC,TBX3,SOX9,FOXA2,SOX17
GO:0002696	positive regulation of leukocyte activation	0.00023607579466931327	0.00023607579466931327	+1	PIK3CA,PIK3R1,GATA3,RUNX1,CEBPA,AKT1,TLR4,TGFBR2,CBFB,PTPN11,MIR142
GO:0045785	positive regulation of cell adhesion	0.00023607579466931327	0.00023607579466931327	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,ATM,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:0009605	response to external stimulus	0.00023835825710393302	0.00023835825710393302	+1	TP53,PIK3CA,PTEN,KRAS,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,MAP3K1,ARHGAP35,NRAS,MAP2K4,CEBPA,EPHA3,EPPK1,PIK3CG,SOX9,HGF,MTOR,TLR4,LRRK2,KIT,SETD2,PDGFRA,EP300,FOXA2,CDKN1A,SIN3A,PTPN11,EGR3,MIR142
GO:0008406	gonad development	0.00023870851528833955	0.00023870851528833955	+1	GATA3,AR,SOX9,WT1,KIT,PDGFRA
GO:0001666	response to hypoxia	0.00024070223993121235	0.00024070223993121235	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0003208	cardiac ventricle morphogenesis	0.0002506522196595211	0.0002506522196595211	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:1903364	positive regulation of cellular protein catabolic process	0.0002564963015649541	0.0002564963015649541	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0031330	negative regulation of cellular catabolic process	0.0002566438056809875	0.0002566438056809875	+1	PIK3CA,CDKN2A,AKT1,HGF,MTOR,LRRK2,TAF1,RPL5,AXIN2
GO:0050870	positive regulation of T cell activation	0.00026745517509031344	0.00026745517509031344	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0040011	locomotion	0.00026745517509031344	0.00026745517509031344	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0021953	central nervous system neuron differentiation	0.00026802645645511105	0.00026802645645511105	+1	PTEN,CTNNB1,ARHGAP35,ERBB4,FGFR2,SIN3A
GO:0048705	skeletal system morphogenesis	0.00026802645645511105	0.00026802645645511105	+1	CTNNB1,SOX9,PDGFRA,FGFR2,FGFR3,TGFBR2
GO:0045137	development of primary sexual characteristics	0.00026802645645511105	0.00026802645645511105	+1	GATA3,AR,SOX9,WT1,KIT,PDGFRA
GO:0048145	regulation of fibroblast proliferation	0.00027122999549042366	0.00027122999549042366	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:0036293	response to decreased oxygen levels	0.0002714823151997549	0.0002714823151997549	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0016242	negative regulation of macroautophagy	0.0002779260472459056	0.0002779260472459056	+1	PIK3CA,AKT1,MTOR,LRRK2
GO:0045834	positive regulation of lipid metabolic process	0.0002784848411852803	0.0002784848411852803	+1	FLT3,AKT1,ERBB4,MTOR,KIT,PDGFRA,FGFR3
GO:0016567	protein ubiquitination	0.00028080951689013814	0.00028080951689013814	+1	PTEN,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,AKT1,BRCA1,LRRK2,USP9X,TAF1,CBFB,HIST1H2BD,RPL5,SPOP
GO:0006275	regulation of DNA replication	0.0002829167709820355	0.0002829167709820355	+1	EGFR,ATRX,CHEK2,PPP2R1A,ATR,SMC3
GO:0048144	fibroblast proliferation	0.0002940376947948071	0.0002940376947948071	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	0.00029543974569893445	0.00029543974569893445	+1	EP300,TAF1,NSD1
GO:0045945	positive regulation of transcription by RNA polymerase III	0.00029543974569893445	0.00029543974569893445	+1	CEBPA,AR,MTOR
GO:0070601	centromeric sister chromatid cohesion	0.00029543974569893445	0.00029543974569893445	+1	CTNNB1,CTCF,AXIN2
GO:0050867	positive regulation of cell activation	0.00029543974569893445	0.00029543974569893445	+1	PIK3CA,PIK3R1,GATA3,RUNX1,CEBPA,AKT1,TLR4,TGFBR2,CBFB,PTPN11,MIR142
GO:1901989	positive regulation of cell cycle phase transition	0.0002978970853837271	0.0002978970853837271	+1	EGFR,RB1,NPM1,AKT1,CCND1,EZH2
GO:0019827	stem cell population maintenance	0.0002978970853837271	0.0002978970853837271	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
GO:0031396	regulation of protein ubiquitination	0.0003047415729981591	0.0003047415729981591	+1	PTEN,CDKN2A,FBXW7,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0030335	positive regulation of cell migration	0.0003140113239086279	0.0003140113239086279	+1	APC,EGFR,GATA3,NOTCH1,AKT1,PIK3CG,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:0050680	negative regulation of epithelial cell proliferation	0.00031530575985920875	0.00031530575985920875	+1	NF1,GATA3,FBXW7,EPPK1,SOX9,FGFR2,BRCA2
GO:0098727	maintenance of cell number	0.00031530575985920875	0.00031530575985920875	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
GO:0008584	male gonad development	0.0003154280585327096	0.0003154280585327096	+1	GATA3,AR,SOX9,WT1,KIT
GO:0051494	negative regulation of cytoskeleton organization	0.0003297273198577584	0.0003297273198577584	+1	PIK3CA,APC,NAV3,PIK3R1,NPM1,BRCA1,SMAD4
GO:0008593	regulation of Notch signaling pathway	0.00033366073016111966	0.00033366073016111966	+1	EGFR,NOTCH1,FBXW7,AKT1,ELF3,EP300
GO:0046546	development of primary male sexual characteristics	0.000342597712966309	0.000342597712966309	+1	GATA3,AR,SOX9,WT1,KIT
GO:0048667	cell morphogenesis involved in neuron differentiation	0.0003538160516936954	0.0003538160516936954	+1	PIK3CA,PTEN,PIK3R1,RB1,NOTCH1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:0060412	ventricular septum morphogenesis	0.00035542282369117347	0.00035542282369117347	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0010518	positive regulation of phospholipase activity	0.00036766253469635896	0.00036766253469635896	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0060348	bone development	0.0003700811957931624	0.0003700811957931624	+1	TP53,FBXW7,SOX9,KIT,FGFR2,FGFR3
GO:0002053	positive regulation of mesenchymal cell proliferation	0.0003894567374624207	0.0003894567374624207	+1	SOX9,FGFR2,TGFBR2
GO:1901800	positive regulation of proteasomal protein catabolic process	0.0003916983057831862	0.0003916983057831862	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0070482	response to oxygen levels	0.00039493031937581924	0.00039493031937581924	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0043406	positive regulation of MAP kinase activity	0.0004004839267364196	0.0004004839267364196	+1	EGFR,FLT3,MAP2K4,PIK3CG,TLR4,LRRK2,KIT,EZH2
GO:0003180	aortic valve morphogenesis	0.000403016440861617	0.000403016440861617	+1	GATA3,RB1,NOTCH1,SOX9
GO:0010506	regulation of autophagy	0.00040369308415097243	0.00040369308415097243	+1	PIK3CA,FBXW7,KEAP1,STK11,AKT1,ATM,HGF,MTOR,LRRK2,EP300
GO:0048738	cardiac muscle tissue development	0.00040369308415097243	0.00040369308415097243	+1	NOTCH1,RUNX1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0046649	lymphocyte activation	0.00042520475604989694	0.00042520475604989694	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,AKT1,PIK3CG,ATM,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0009611	response to wounding	0.0004269405105702633	0.0004269405105702633	+1	PIK3CA,PTEN,NF1,PIK3R1,GATA3,ARHGAP35,EPPK1,PIK3CG,MTOR,TLR4,PDGFRA,FOXA2,PTPN11
GO:2000147	positive regulation of cell motility	0.0004436990703220688	0.0004436990703220688	+1	APC,EGFR,GATA3,NOTCH1,AKT1,PIK3CG,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:0002376	immune system process	0.00044801576794618224	0.00044801576794618224	+1	TP53,PIK3CA,KRAS,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,MAP3K1,FLT3,RUNX1,NRAS,IDH1,MAP2K4,CEBPA,AKT1,PIK3CG,SOX9,ATM,MTOR,TLR4,TET2,POLQ,KIT,SETD2,EP300,FGFR2,TGFBR2,CBFB,SIN3A,PTPN11,ACVR1B,MAPK8IP1,ACVR2A,MECOM,MIR142
GO:0070198	protein localization to chromosome, telomeric region	0.000454790964743629	0.000454790964743629	+1	ATM,ATRX,BRCA2,ATR
GO:0032989	cellular component morphogenesis	0.0004624550175111779	0.0004624550175111779	+1	PIK3CA,PTEN,PIK3R1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,LRRK2,PDGFRA,FGFR2,SMAD4,USP9X,SIN3A,PTPN11
GO:0040029	regulation of gene expression, epigenetic	0.0004741277073310616	0.0004741277073310616	+1	ARID1A,DNMT3A,CTCF,BRCA1,EP300,SF3B1,SIN3A,EZH2
GO:0003205	cardiac chamber development	0.00048410379269489166	0.00048410379269489166	+1	GATA3,NOTCH1,TBX3,FGFR2,SMAD4,TGFBR2
GO:0030855	epithelial cell differentiation	0.0004950612879020278	0.0004950612879020278	+1	GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,SOX9,WT1,ERBB4,FGFR2,SMAD4,SOX17,CBFB,VEZF1,ERCC2
GO:0002573	myeloid leukocyte differentiation	0.0004973565107931221	0.0004973565107931221	+1	FBXW7,RUNX1,CEBPA,MTOR,TLR4,KIT,TGFBR2
GO:0051547	regulation of keratinocyte migration	0.0005011834097571357	0.0005011834097571357	+1	PTEN,EPPK1,MTOR
GO:2000136	regulation of cell proliferation involved in heart morphogenesis	0.0005011834097571357	0.0005011834097571357	+1	NOTCH1,CTNNB1,SMAD4
GO:0035239	tube morphogenesis	0.0005027350298292163	0.0005027350298292163	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,TBX3,AKT1,SOX9,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0006333	chromatin assembly or disassembly	0.0005039723412360893	0.0005039723412360893	+1	TP53,ARID1A,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H2BD
GO:0038128	ERBB2 signaling pathway	0.0005083974040310981	0.0005083974040310981	+1	PIK3CA,EGFR,PIK3R1,ERBB4
GO:0040017	positive regulation of locomotion	0.0005189499776579318	0.0005189499776579318	+1	APC,EGFR,GATA3,NOTCH1,AKT1,PIK3CG,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:1903039	positive regulation of leukocyte cell-cell adhesion	0.0005198721911495508	0.0005198721911495508	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0060419	heart growth	0.0005287941248186245	0.0005287941248186245	+1	NOTCH1,RUNX1,WT1,ERBB4,FGFR2
GO:0044265	cellular macromolecule catabolic process	0.0005433976605447203	0.0005433976605447203	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,RPL22,CEBPA,AKT1,ATM,LRRK2,CHEK2,USP9X,TAF1,PPP2R1A,TBL1XR1,RPL5,SPOP,AXIN2
GO:0033146	regulation of intracellular estrogen receptor signaling pathway	0.0005697205010638998	0.0005697205010638998	+1	RUNX1,BRCA1,FOXA1,CBFB
GO:0010828	positive regulation of glucose transmembrane transport	0.0005697205010638998	0.0005697205010638998	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:1902105	regulation of leukocyte differentiation	0.000573700169265155	0.000573700169265155	+1	CDKN2A,GATA3,FBXW7,RUNX1,MTOR,TLR4,TGFBR2,CBFB
GO:0019221	cytokine-mediated signaling pathway	0.0005758014209340108	0.0005758014209340108	+1	TP53,PIK3CA,PIK3R1,GATA3,FLT3,RUNX1,CEBPA,AKT1,HGF,KIT,CCND1,SMAD4,CDKN1A,CBFB,PTPN11,LIFR
GO:0007259	receptor signaling pathway via JAK-STAT	0.0006035260867648556	0.0006035260867648556	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0003279	cardiac septum development	0.000609049563887798	0.000609049563887798	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0032147	activation of protein kinase activity	0.0006153652288940197	0.0006153652288940197	+1	MAP2K4,STK11,AKT1,BRAF,MTOR,TLR4,LRRK2,KIT,TGFBR2
GO:0042752	regulation of circadian rhythm	0.0006192724474397021	0.0006192724474397021	+1	TP53,FBXW7,MTOR,USP9X,SIN3A,EZH2
GO:0045662	negative regulation of myoblast differentiation	0.0006304114911542796	0.0006304114911542796	+1	NOTCH1,TBX3,SOX9
GO:0061323	cell proliferation involved in heart morphogenesis	0.0006304114911542796	0.0006304114911542796	+1	NOTCH1,CTNNB1,SMAD4
GO:0003176	aortic valve development	0.0006318394797733747	0.0006318394797733747	+1	GATA3,RB1,NOTCH1,SOX9
GO:0045922	negative regulation of fatty acid metabolic process	0.0006318394797733747	0.0006318394797733747	+1	AKT1,SOX9,BRCA1,NCOR1
GO:0071241	cellular response to inorganic substance	0.0006756916368919993	0.0006756916368919993	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,ATRX,LRRK2
GO:2000736	regulation of stem cell differentiation	0.0006824042041999065	0.0006824042041999065	+1	GATA3,NOTCH1,RUNX1,SOX9,PDGFRA,CBFB
GO:0048754	branching morphogenesis of an epithelial tube	0.0006956995850789553	0.0006956995850789553	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
GO:0060421	positive regulation of heart growth	0.0007026932612725908	0.0007026932612725908	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0007405	neuroblast proliferation	0.0007026932612725908	0.0007026932612725908	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:0046622	positive regulation of organ growth	0.0007026932612725908	0.0007026932612725908	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:2001020	regulation of response to DNA damage stimulus	0.0007363990238003235	0.0007363990238003235	+1	EGFR,CDKN2A,ATM,BRCA1,POLQ,SETD2,ATR,AXIN2
GO:0010517	regulation of phospholipase activity	0.0007404634319463504	0.0007404634319463504	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0031099	regeneration	0.0007404634319463504	0.0007404634319463504	+1	RUNX1,EPPK1,CDKN1B,ERBB4,CDKN1A
GO:1902749	regulation of cell cycle G2/M phase transition	0.0007562422346921501	0.0007562422346921501	+1	TP53,CDKN2A,NPM1,ATM,BRCA1,CCND1,CDKN1A,PPP2R1A
GO:0065004	protein-DNA complex assembly	0.0007562422346921501	0.0007562422346921501	+1	TP53,RB1,NPM1,SOX9,ATRX,TAF1,HIST1H2BD,ERCC2
GO:0048666	neuron development	0.0007562422346921501	0.0007562422346921501	+1	PIK3CA,PTEN,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,LRRK2,EP300,FGFR2,USP9X,SIN3A,PTPN11
GO:0003214	cardiac left ventricle morphogenesis	0.0007744805845335907	0.0007744805845335907	+1	NOTCH1,SMAD4,TGFBR2
GO:0043627	response to estrogen	0.0007744805845335907	0.0007744805845335907	+1	GATA3,AR,BRCA1,EP300
GO:0072132	mesenchyme morphogenesis	0.0007744805845335907	0.0007744805845335907	+1	NOTCH1,SOX9,TGFBR2,SMAD2
GO:0070141	response to UV-A	0.0007744805845335907	0.0007744805845335907	+1	EGFR,AKT1,CCND1
GO:0048701	embryonic cranial skeleton morphogenesis	0.0007744805845335907	0.0007744805845335907	+1	PDGFRA,FGFR2,TGFBR2
GO:0035051	cardiocyte differentiation	0.0007775692208472134	0.0007775692208472134	+1	EGFR,NOTCH1,WT1,PDGFRA,SMAD4,SOX17
GO:0010035	response to inorganic substance	0.0007963167224126559	0.0007963167224126559	+1	PIK3CA,EGFR,CDH1,NFE2L2,AKT1,BRAF,CDKN1B,HGF,ATRX,LRRK2
GO:0032446	protein modification by small protein conjugation	0.0008165239718801786	0.0008165239718801786	+1	PTEN,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,AKT1,BRCA1,LRRK2,USP9X,TAF1,CBFB,HIST1H2BD,RPL5,SPOP
GO:0033036	macromolecule localization	0.0008294189421268739	0.0008294189421268739	+1	TP53,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,KEAP1,CDH1,CTCF,BAP1,NPM1,IDH1,RPL22,EPHA3,AKT1,BRAF,AR,ATM,TLR4,U2AF1,ATRX,LRRK2,SETD2,FOXA2,USP9X,BRCA2,TGFBR2,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:0060193	positive regulation of lipase activity	0.0008347999311748658	0.0008347999311748658	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0048704	embryonic skeletal system morphogenesis	0.0008523766300749149	0.0008523766300749149	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:0031056	regulation of histone modification	0.0008523766300749149	0.0008523766300749149	+1	CTNNB1,ATRX,BRCA1,SMAD4,SIN3A,NSD1
GO:0000226	microtubule cytoskeleton organization	0.0008559214806278338	0.0008559214806278338	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,CHEK2,SETD2,BRCA2,SMC1A,SMC3,NCOR1
GO:0031175	neuron projection development	0.0008559214806278338	0.0008559214806278338	+1	PIK3CA,PTEN,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,EP300,FGFR2,USP9X,SIN3A,PTPN11
GO:0097696	receptor signaling pathway via STAT	0.000860557482177901	0.000860557482177901	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0072073	kidney epithelium development	0.0008857032890819112	0.0008857032890819112	+1	GATA3,CTNNB1,SOX9,WT1,FGFR2
GO:1903037	regulation of leukocyte cell-cell adhesion	0.0008949346582454369	0.0008949346582454369	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.0008949346582454369	0.0008949346582454369	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0051546	keratinocyte migration	0.0009296663798108206	0.0009296663798108206	+1	PTEN,EPPK1,MTOR
GO:0051571	positive regulation of histone H3-K4 methylation	0.0009296663798108206	0.0009296663798108206	+1	CTNNB1,BRCA1,SMAD4
GO:0030521	androgen receptor signaling pathway	0.0009296663798108206	0.0009296663798108206	+1	ARID1A,AR,EP300,NCOR1
GO:0006511	ubiquitin-dependent protein catabolic process	0.0009321246194304147	0.0009321246194304147	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0061061	muscle structure development	0.0009408244215085529	0.0009408244215085529	+1	RB1,NOTCH1,CTNNB1,TBX3,SOX9,WT1,KIT,PDGFRA,FGFR2,SMAD4,EGR3
GO:0034728	nucleosome organization	0.0009424274840490078	0.0009424274840490078	+1	ARID1A,CTCF,NPM1,SOX9,ATRX,SETD2,HIST1H2BD
GO:0050679	positive regulation of epithelial cell proliferation	0.0009424274840490078	0.0009424274840490078	+1	EGFR,NRAS,AKT1,SOX9,TLR4,FGFR2,EGR3
GO:0060537	muscle tissue development	0.0009629441325986274	0.0009629441325986274	+1	NF1,NOTCH1,RUNX1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:1901575	organic substance catabolic process	0.000974870719929236	0.000974870719929236	+1	TP53,PTEN,APC,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,RPL22,CEBPA,AKT1,ATM,CDKN1B,MTOR,TET2,LRRK2,CHEK2,EP300,USP9X,TAF1,PPP2R1A,TBL1XR1,NCOR1,RPL5,SPOP,AXIN2
GO:0071456	cellular response to hypoxia	0.000974870719929236	0.000974870719929236	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:0010507	negative regulation of autophagy	0.0009822107071711659	0.0009822107071711659	+1	PIK3CA,AKT1,HGF,MTOR,LRRK2
GO:0010001	glial cell differentiation	0.0009985526658219833	0.0009985526658219833	+1	PTEN,NF1,NOTCH1,SOX9,PRX,MIR142
GO:0060043	regulation of cardiac muscle cell proliferation	0.0010047938944145014	0.0010047938944145014	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:1905314	semi-lunar valve development	0.0010047938944145014	0.0010047938944145014	+1	GATA3,RB1,NOTCH1,SOX9
GO:0046660	female sex differentiation	0.0010047938944145014	0.0010047938944145014	+1	TBX3,WT1,KIT,PDGFRA
GO:0019941	modification-dependent protein catabolic process	0.0010047938944145014	0.0010047938944145014	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0048812	neuron projection morphogenesis	0.0010136115953912146	0.0010136115953912146	+1	PIK3CA,PTEN,PIK3R1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:0032481	positive regulation of type I interferon production	0.0010376594055776125	0.0010376594055776125	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:0051249	regulation of lymphocyte activation	0.0010468910506355722	0.0010468910506355722	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,ATM,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0007409	axonogenesis	0.001054132127584061	0.001054132127584061	+1	PIK3CA,PTEN,PIK3R1,NOTCH1,ARHGAP35,EPHA3,FGFR2,USP9X,SIN3A,PTPN11
GO:1902106	negative regulation of leukocyte differentiation	0.0011005616497956883	0.0011005616497956883	+1	CDKN2A,FBXW7,RUNX1,TLR4,CBFB
GO:0010719	negative regulation of epithelial to mesenchymal transition	0.0011005616497956883	0.0011005616497956883	+1	PTEN,GATA3,FOXA1,FOXA2
GO:0010464	regulation of mesenchymal cell proliferation	0.0011017106323420874	0.0011017106323420874	+1	SOX9,FGFR2,TGFBR2
GO:0048485	sympathetic nervous system development	0.0011017106323420874	0.0011017106323420874	+1	NF1,GATA3,CTNNB1
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	0.0011017106323420874	0.0011017106323420874	+1	CDKN2A,ATM,ATR
GO:0036294	cellular response to decreased oxygen levels	0.0011068868231489404	0.0011068868231489404	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:0031929	TOR signaling	0.0011241927438926155	0.0011241927438926155	+1	PIK3CA,GATA3,STK11,AKT1,ATM,MTOR
GO:0061448	connective tissue development	0.0011241927438926155	0.0011241927438926155	+1	RUNX1,SOX9,WT1,ARID5B,FGFR3,PTPN11
GO:0010632	regulation of epithelial cell migration	0.0011414335993944614	0.0011414335993944614	+1	PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,PIK3CG,SOX9,MTOR
GO:0003231	cardiac ventricle development	0.0011584279054668199	0.0011584279054668199	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0006928	movement of cell or subcellular component	0.0011652379717861936	0.0011652379717861936	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,STK11,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0043632	modification-dependent macromolecule catabolic process	0.0011843023965318034	0.0011843023965318034	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0001889	liver development	0.0011901840231128965	0.0011901840231128965	+1	NF1,FBXW7,CEBPA,ARID5B
GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	0.0011901840231128965	0.0011901840231128965	+1	TP53,GATA3,SOX9,WT1
GO:0001657	ureteric bud development	0.0011901840231128965	0.0011901840231128965	+1	GATA3,SOX9,WT1,FGFR2
GO:0034614	cellular response to reactive oxygen species	0.0012188395707482809	0.0012188395707482809	+1	EGFR,NFE2L2,AKT1,HGF,LRRK2,PDGFRA
GO:0042509	regulation of tyrosine phosphorylation of STAT protein	0.0012206324386393453	0.0012206324386393453	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0030162	regulation of proteolysis	0.0012361029064944992	0.0012361029064944992	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,RUNX1,CEBPA,AKT1,HGF,LRRK2,TAF1,RPL5,SPOP
GO:0051641	cellular localization	0.0012531156226721866	0.0012531156226721866	+1	TP53,PTEN,APC,EGFR,PIK3R1,CDKN2A,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,NRAS,IDH1,RPL22,STK11,EPHA3,AKT1,BRAF,AR,PIK3CG,ATM,HGF,MTOR,U2AF1,ATRX,LRRK2,KIT,SETD2,FOXA2,USP9X,BRCA2,PPP2R1A,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:0120039	plasma membrane bounded cell projection morphogenesis	0.0012531156226721866	0.0012531156226721866	+1	PIK3CA,PTEN,PIK3R1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:0043388	positive regulation of DNA binding	0.0012858025645138386	0.0012858025645138386	+1	GATA3,RB1,CTNNB1,EP300
GO:0031497	chromatin assembly	0.0012858025645138386	0.0012858025645138386	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H2BD
GO:1903707	negative regulation of hemopoiesis	0.0012858025645138386	0.0012858025645138386	+1	CDKN2A,FBXW7,RUNX1,TLR4,CBFB
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	0.0012858025645138386	0.0012858025645138386	+1	EGFR,AKT1,CCND1
GO:0071480	cellular response to gamma radiation	0.0012858025645138386	0.0012858025645138386	+1	TP53,ATM,ATR
GO:0061614	pri-miRNA transcription by RNA polymerase II	0.0012858025645138386	0.0012858025645138386	+1	TP53,GATA3,SOX9,WT1
GO:0072163	mesonephric epithelium development	0.0012858025645138386	0.0012858025645138386	+1	GATA3,SOX9,WT1,FGFR2
GO:0072164	mesonephric tubule development	0.0012858025645138386	0.0012858025645138386	+1	GATA3,SOX9,WT1,FGFR2
GO:0060038	cardiac muscle cell proliferation	0.0012858025645138386	0.0012858025645138386	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0048858	cell projection morphogenesis	0.0013058946798460145	0.0013058946798460145	+1	PIK3CA,PTEN,PIK3R1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:0007267	cell-cell signaling	0.001318457816849708	0.001318457816849708	+1	PTEN,APC,EGFR,GATA3,CTNNB1,TSHZ3,RUNX1,TBX3,STK11,AKT1,AR,SOX9,HGF,LRRK2,FGFR2,FOXA2,SOX17,PPP2R1A,CBFB,TBL1XR1,AXIN2,MIR142
GO:0044728	DNA methylation or demethylation	0.0013462914292689699	0.0013462914292689699	+1	DNMT3A,WT1,TET2,ATRX,USP9X
GO:0007368	determination of left/right symmetry	0.0013462914292689699	0.0013462914292689699	+1	NOTCH1,TBX3,TGFBR2,SOX17,SMAD2
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0013462914292689699	0.0013462914292689699	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0061008	hepaticobiliary system development	0.0013944401745122775	0.0013944401745122775	+1	NF1,FBXW7,CEBPA,ARID5B
GO:0046822	regulation of nucleocytoplasmic transport	0.0014231766368290025	0.0014231766368290025	+1	TP53,PIK3R1,CDKN2A,CDH1,SETD2
GO:0007260	tyrosine phosphorylation of STAT protein	0.0014231766368290025	0.0014231766368290025	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.0014904725320714273	0.0014904725320714273	+1	NOTCH1,STK11,EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:2001185	regulation of CD8-positive, alpha-beta T cell activation	0.0015094152278567125	0.0015094152278567125	+1	RUNX1,CBFB,MAPK8IP1
GO:0070200	establishment of protein localization to telomere	0.0015094152278567125	0.0015094152278567125	+1	ATM,BRCA2,ATR
GO:0062009	secondary palate development	0.0015094152278567125	0.0015094152278567125	+1	SMAD4,TGFBR2,SMAD2
GO:0001947	heart looping	0.001510709098604099	0.001510709098604099	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:0030856	regulation of epithelial cell differentiation	0.0015321200341002776	0.0015321200341002776	+1	GATA3,CTNNB1,RUNX1,SOX9,CBFB,VEZF1
GO:0032990	cell part morphogenesis	0.0015348333340879012	0.0015348333340879012	+1	PIK3CA,PTEN,PIK3R1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:0048285	organelle fission	0.0015348333340879012	0.0015348333340879012	+1	APC,RB1,STAG2,ATM,ATRX,LRRK2,CHEK2,PPP2R1A,SMC1A,SMC3,RAD21
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	0.0015755721193905531	0.0015755721193905531	+1	TP53,ATM,BRCA1,CHEK2,EP300
GO:0003206	cardiac chamber morphogenesis	0.0015755721193905531	0.0015755721193905531	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:2000379	positive regulation of reactive oxygen species metabolic process	0.0015755721193905531	0.0015755721193905531	+1	TP53,AKT1,TLR4,TGFBR2,CDKN1A
GO:0071453	cellular response to oxygen levels	0.001596907010343139	0.001596907010343139	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:0002011	morphogenesis of an epithelial sheet	0.0016265054118675347	0.0016265054118675347	+1	PTEN,NOTCH1,ARHGAP35,MTOR
GO:0006383	transcription by RNA polymerase III	0.0016265054118675347	0.0016265054118675347	+1	CEBPA,AR,MTOR,BRCA1
GO:0055021	regulation of cardiac muscle tissue growth	0.0016265054118675347	0.0016265054118675347	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0000902	cell morphogenesis	0.0016416614715923116	0.0016416614715923116	+1	PIK3CA,PTEN,VHL,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,LRRK2,KIT,FGFR2,USP9X,SIN3A,PTPN11
GO:0060736	prostate gland growth	0.0016474010044105747	0.0016474010044105747	+1	SOX9,FGFR2
GO:0071600	otic vesicle morphogenesis	0.0016474010044105747	0.0016474010044105747	+1	SOX9,FGFR2
GO:0030916	otic vesicle formation	0.0016474010044105747	0.0016474010044105747	+1	SOX9,FGFR2
GO:1903321	negative regulation of protein modification by small protein conjugation or removal	0.0016474010044105747	0.0016474010044105747	+1	CDKN2A,CTNNB1,AKT1,TAF1,RPL5
GO:0048873	homeostasis of number of cells within a tissue	0.0016474010044105747	0.0016474010044105747	+1	NOTCH1,SOX9
GO:0035521	monoubiquitinated histone deubiquitination	0.0016474010044105747	0.0016474010044105747	+1	BAP1,ASXL1
GO:2000793	cell proliferation involved in heart valve development	0.0016474010044105747	0.0016474010044105747	+1	NOTCH1,SMAD4
GO:0060740	prostate gland epithelium morphogenesis	0.0016474010044105747	0.0016474010044105747	+1	SOX9,FGFR2
GO:0048853	forebrain morphogenesis	0.0016474010044105747	0.0016474010044105747	+1	PTEN,NF1
GO:0035522	monoubiquitinated histone H2A deubiquitination	0.0016474010044105747	0.0016474010044105747	+1	BAP1,ASXL1
GO:0044089	positive regulation of cellular component biogenesis	0.0016491514908072737	0.0016491514908072737	+1	TP53,PIK3CA,APC,NAV3,PIK3R1,ARHGAP35,AJUBA,ATM,TLR4,ATR,ERCC2
GO:0007420	brain development	0.0016498047853544474	0.0016498047853544474	+1	PTEN,NF1,CTNNB1,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,SIN3A,PTPN11
GO:0061564	axon development	0.0016498047853544474	0.0016498047853544474	+1	PIK3CA,PTEN,PIK3R1,NOTCH1,ARHGAP35,EPHA3,FGFR2,USP9X,SIN3A,PTPN11
GO:0051099	positive regulation of binding	0.001685252935131204	0.001685252935131204	+1	GATA3,RB1,CTNNB1,LRRK2,EP300,TAF1
GO:1902692	regulation of neuroblast proliferation	0.0017164798697696037	0.0017164798697696037	+1	NF1,CTNNB1,LRRK2
GO:2000047	regulation of cell-cell adhesion mediated by cadherin	0.0017164798697696037	0.0017164798697696037	+1	NOTCH1,FOXA1,FOXA2
GO:0048709	oligodendrocyte differentiation	0.0017245574029819653	0.0017245574029819653	+1	PTEN,NF1,NOTCH1,SOX9
GO:0007626	locomotory behavior	0.0017245574029819653	0.0017245574029819653	+1	PTEN,MTOR,FOXA2,NCOR1
GO:0001823	mesonephros development	0.0017245574029819653	0.0017245574029819653	+1	GATA3,SOX9,WT1,FGFR2
GO:0010638	positive regulation of organelle organization	0.001729371514305047	0.001729371514305047	+1	TP53,NAV3,RB1,CTNNB1,ARHGAP35,ATM,ATRX,BRCA1,SMAD4,ATR,SIN3A,RAD21
GO:0032386	regulation of intracellular transport	0.001729371514305047	0.001729371514305047	+1	TP53,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,STK11,LRRK2,SETD2
GO:2001234	negative regulation of apoptotic signaling pathway	0.0017645923208096707	0.0017645923208096707	+1	RB1,NFE2L2,AKT1,AR,HGF,BRCA1,LRRK2
GO:0062014	negative regulation of small molecule metabolic process	0.001797406990703389	0.001797406990703389	+1	AKT1,SOX9,BRCA1,EP300,NCOR1
GO:0035196	production of miRNAs involved in gene silencing by miRNA	0.001854949679050782	0.001854949679050782	+1	TP53,EGFR,NCOR1,SMAD2
GO:0060993	kidney morphogenesis	0.001854949679050782	0.001854949679050782	+1	GATA3,SOX9,WT1,LRRK2
GO:0120163	negative regulation of cold-induced thermogenesis	0.001854949679050782	0.001854949679050782	+1	RB1,NOTCH1,STK11,TLR4
GO:1903961	positive regulation of anion transmembrane transport	0.001854949679050782	0.001854949679050782	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0043009	chordate embryonic development	0.001870362926456764	0.001870362926456764	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:0009855	determination of bilateral symmetry	0.0018840369507617963	0.0018840369507617963	+1	NOTCH1,TBX3,TGFBR2,SOX17,SMAD2
GO:0007159	leukocyte cell-cell adhesion	0.0019247323449424838	0.0019247323449424838	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0009056	catabolic process	0.001929455393938544	0.001929455393938544	+1	TP53,PIK3CA,PTEN,APC,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,RPL22,STK11,CEBPA,AKT1,ATM,CDKN1B,HGF,MTOR,TET2,LRRK2,CHEK2,EP300,USP9X,TAF1,PPP2R1A,TBL1XR1,NCOR1,RPL5,SPOP,AXIN2
GO:0007219	Notch signaling pathway	0.0019413065840316482	0.0019413065840316482	+1	EGFR,NOTCH1,FBXW7,AKT1,ELF3,EP300
GO:0045321	leukocyte activation	0.0019481139836838714	0.0019481139836838714	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,NRAS,IDH1,CEBPA,AKT1,PIK3CG,ATM,TLR4,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:1903798	regulation of production of miRNAs involved in gene silencing by miRNA	0.0019516001863521058	0.0019516001863521058	+1	TP53,EGFR,NCOR1
GO:0070920	regulation of production of small RNA involved in gene silencing by RNA	0.0019516001863521058	0.0019516001863521058	+1	TP53,EGFR,NCOR1
GO:1904031	positive regulation of cyclin-dependent protein kinase activity	0.0019516001863521058	0.0019516001863521058	+1	EGFR,AKT1,CCND1
GO:0003181	atrioventricular valve morphogenesis	0.0019516001863521058	0.0019516001863521058	+1	NOTCH1,SMAD4,TGFBR2
GO:0032925	regulation of activin receptor signaling pathway	0.0019516001863521058	0.0019516001863521058	+1	ACVR1B,ACVR2A,SMAD2
GO:0009799	specification of symmetry	0.001963306344918061	0.001963306344918061	+1	NOTCH1,TBX3,TGFBR2,SOX17,SMAD2
GO:0003143	embryonic heart tube morphogenesis	0.001973576104577415	0.001973576104577415	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:0061371	determination of heart left/right asymmetry	0.001973576104577415	0.001973576104577415	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:0001570	vasculogenesis	0.001973576104577415	0.001973576104577415	+1	NOTCH1,WT1,TGFBR2,SOX17
GO:0071248	cellular response to metal ion	0.0019927006642851412	0.0019927006642851412	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:0043254	regulation of protein-containing complex assembly	0.0020411468961268283	0.0020411468961268283	+1	TP53,NAV3,RB1,AJUBA,ATM,TLR4,EP300,ATR,PTPN11,ERCC2
GO:0007610	behavior	0.0020482058530861495	0.0020482058530861495	+1	TP53,PTEN,EGFR,NF1,MTOR,LRRK2,FOXA2,NCOR1
GO:0051493	regulation of cytoskeleton organization	0.0020548798013234303	0.0020548798013234303	+1	PIK3CA,APC,NAV3,PIK3R1,ARHGAP35,NPM1,EPHA3,MTOR,BRCA1,PDGFRA,SMAD4
GO:0060560	developmental growth involved in morphogenesis	0.002058222852767379	0.002058222852767379	+1	NOTCH1,CTNNB1,SOX9,FGFR2,USP9X,SIN3A
GO:0071773	cellular response to BMP stimulus	0.002058222852767379	0.002058222852767379	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0071772	response to BMP	0.002058222852767379	0.002058222852767379	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0070741	response to interleukin-6	0.0021100427472333476	0.0021100427472333476	+1	CEBPA,SMAD4,FOXA2,PTPN11
GO:1902808	positive regulation of cell cycle G1/S phase transition	0.0021100427472333476	0.0021100427472333476	+1	EGFR,AKT1,CCND1,EZH2
GO:0072080	nephron tubule development	0.0021100427472333476	0.0021100427472333476	+1	GATA3,CTNNB1,SOX9,WT1
GO:0030219	megakaryocyte differentiation	0.002144810264547996	0.002144810264547996	+1	RUNX1,KIT,EP300,CBFB,SIN3A
GO:0030098	lymphocyte differentiation	0.0021941569805078165	0.0021941569805078165	+1	CDKN2A,GATA3,FLT3,RUNX1,ATM,KIT,TGFBR2,CBFB
GO:0010463	mesenchymal cell proliferation	0.0022105953447742396	0.0022105953447742396	+1	SOX9,FGFR2,TGFBR2
GO:0051569	regulation of histone H3-K4 methylation	0.0022105953447742396	0.0022105953447742396	+1	CTNNB1,BRCA1,SMAD4
GO:0048806	genitalia development	0.0022105953447742396	0.0022105953447742396	+1	TBX3,WT1,PTPN11
GO:1903076	regulation of protein localization to plasma membrane	0.0022454024292506117	0.0022454024292506117	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0070918	production of small RNA involved in gene silencing by RNA	0.0022466581454661963	0.0022466581454661963	+1	TP53,EGFR,NCOR1,SMAD2
GO:0031050	dsRNA processing	0.0022466581454661963	0.0022466581454661963	+1	TP53,EGFR,NCOR1,SMAD2
GO:0071260	cellular response to mechanical stimulus	0.0022466581454661963	0.0022466581454661963	+1	MAP3K1,MAP2K4,SOX9,TLR4
GO:0061326	renal tubule development	0.0022466581454661963	0.0022466581454661963	+1	GATA3,CTNNB1,SOX9,WT1
GO:0060411	cardiac septum morphogenesis	0.0022466581454661963	0.0022466581454661963	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0051438	regulation of ubiquitin-protein transferase activity	0.0022466581454661963	0.0022466581454661963	+1	PTEN,CDKN2A,FBXW7,RPL5
GO:0060322	head development	0.0022473719063913506	0.0022473719063913506	+1	PTEN,NF1,CTNNB1,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,SIN3A,PTPN11
GO:0000904	cell morphogenesis involved in differentiation	0.002257409251570853	0.002257409251570853	+1	PIK3CA,PTEN,PIK3R1,RB1,NOTCH1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:0044257	cellular protein catabolic process	0.002328724388224946	0.002328724388224946	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,CHEK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0097305	response to alcohol	0.0023316788801634424	0.0023316788801634424	+1	CTNNB1,CDH1,BRCA1,TGFBR2,SMAD2
GO:0072006	nephron development	0.0023316788801634424	0.0023316788801634424	+1	GATA3,CTNNB1,SOX9,WT1,PDGFRA
GO:0030168	platelet activation	0.0023446719092050663	0.0023446719092050663	+1	PIK3CA,PIK3R1,PIK3CG,TLR4,PDGFRA,PTPN11
GO:0009798	axis specification	0.002394510812840613	0.002394510812840613	+1	TBX3,WT1,FOXA2,SMAD2
GO:1903202	negative regulation of oxidative stress-induced cell death	0.002394510812840613	0.002394510812840613	+1	NFE2L2,AKT1,HGF,LRRK2
GO:0048706	embryonic skeletal system development	0.002394510812840613	0.002394510812840613	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:0014855	striated muscle cell proliferation	0.002394510812840613	0.002394510812840613	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0000280	nuclear division	0.002405784813198193	0.002405784813198193	+1	APC,RB1,STAG2,ATM,ATRX,CHEK2,PPP2R1A,SMC1A,SMC3,RAD21
GO:0061919	process utilizing autophagic mechanism	0.002417103871069752	0.002417103871069752	+1	TP53,PIK3CA,FBXW7,KEAP1,STK11,AKT1,ATM,HGF,MTOR,LRRK2,EP300
GO:0006914	autophagy	0.002417103871069752	0.002417103871069752	+1	TP53,PIK3CA,FBXW7,KEAP1,STK11,AKT1,ATM,HGF,MTOR,LRRK2,EP300
GO:0070925	organelle assembly	0.002427360097127848	0.002427360097127848	+1	PTEN,NOTCH1,ARHGAP35,NPM1,STAG2,BRCA1,LRRK2,CHEK2,PDGFRA,SMAD4,PPP2R1A,SMC1A,SMC3,NCOR1,RPL5
GO:0007264	small GTPase mediated signal transduction	0.0024422288372394855	0.0024422288372394855	+1	TP53,KRAS,NF1,CDKN2A,RB1,NOTCH1,ARHGAP35,NRAS,PIK3CG,CDKN1A
GO:0060512	prostate gland morphogenesis	0.0024464065963776547	0.0024464065963776547	+1	SOX9,FGFR2
GO:0048546	digestive tract morphogenesis	0.0024464065963776547	0.0024464065963776547	+1	PDGFRA,FGFR2,SOX17
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.0024464065963776547	0.0024464065963776547	+1	NOTCH1,NFE2L2
GO:0060729	intestinal epithelial structure maintenance	0.0024464065963776547	0.0024464065963776547	+1	SOX9,TLR4
GO:0003171	atrioventricular valve development	0.0024464065963776547	0.0024464065963776547	+1	NOTCH1,SMAD4,TGFBR2
GO:1901798	positive regulation of signal transduction by p53 class mediator	0.0024464065963776547	0.0024464065963776547	+1	CDKN2A,ATM,ATR
GO:0043032	positive regulation of macrophage activation	0.0024464065963776547	0.0024464065963776547	+1	CEBPA,TLR4,MIR142
GO:0010226	response to lithium ion	0.0024464065963776547	0.0024464065963776547	+1	CDH1,CDKN1B
GO:0036037	CD8-positive, alpha-beta T cell activation	0.0024464065963776547	0.0024464065963776547	+1	RUNX1,CBFB,MAPK8IP1
GO:0030539	male genitalia development	0.0024464065963776547	0.0024464065963776547	+1	TBX3,WT1
GO:0003149	membranous septum morphogenesis	0.0024464065963776547	0.0024464065963776547	+1	FGFR2,TGFBR2
GO:1903223	positive regulation of oxidative stress-induced neuron death	0.0024464065963776547	0.0024464065963776547	+1	FBXW7,TLR4
GO:0003160	endocardium morphogenesis	0.0024464065963776547	0.0024464065963776547	+1	NOTCH1,SOX17
GO:1904666	regulation of ubiquitin protein ligase activity	0.0024464065963776547	0.0024464065963776547	+1	PTEN,CDKN2A,RPL5
GO:0006102	isocitrate metabolic process	0.0024464065963776547	0.0024464065963776547	+1	IDH1,IDH2
GO:2000435	negative regulation of protein neddylation	0.0024464065963776547	0.0024464065963776547	+1	CDKN2A,RPL5
GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	0.0024464065963776547	0.0024464065963776547	+1	RUNX1,CBFB
GO:2000617	positive regulation of histone H3-K9 acetylation	0.0024464065963776547	0.0024464065963776547	+1	BRCA1,SMAD4
GO:0046425	regulation of receptor signaling pathway via JAK-STAT	0.0024897301827731446	0.0024897301827731446	+1	VHL,NOTCH1,ERBB4,KIT,PPP2R1A
GO:0022414	reproductive process	0.0024940458625543234	0.0024940458625543234	+1	GATA3,TBX3,AR,SOX9,ATM,WT1,KIT,PDGFRA,FGFR2,USP9X,SMC1A,PTPN11,ACVR1B,SMC3,RAD21
GO:0031295	T cell costimulation	0.0024993703654819046	0.0024993703654819046	+1	PIK3CA,PIK3R1,AKT1,PTPN11
GO:0010821	regulation of mitochondrion organization	0.0025305159136422262	0.0025305159136422262	+1	TP53,FBXW7,AKT1,HGF,LRRK2,EP300
GO:0042592	homeostatic process	0.0025505193849581272	0.0025505193849581272	+1	APC,NF1,PIK3R1,RB1,NOTCH1,FBXW7,FLT3,NFE2L2,STK11,CEBPA,AKT1,SOX9,ATM,TLR4,ATRX,LRRK2,KIT,PDGFRA,SMAD4,FOXA2,ATR,ACVR1B,ACVR2A
GO:0060191	regulation of lipase activity	0.0025945342023427284	0.0025945342023427284	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0045833	negative regulation of lipid metabolic process	0.0025945342023427284	0.0025945342023427284	+1	FBXW7,AKT1,SOX9,BRCA1,NCOR1
GO:1901565	organonitrogen compound catabolic process	0.002597770139896301	0.002597770139896301	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,CDKN1B,MTOR,TET2,LRRK2,CHEK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0000003	reproduction	0.002602866530246778	0.002602866530246778	+1	GATA3,TBX3,AR,SOX9,ATM,WT1,KIT,PDGFRA,FGFR2,USP9X,SMC1A,PTPN11,ACVR1B,SMC3,RAD21
GO:0048514	blood vessel morphogenesis	0.002611398544592023	0.002611398544592023	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0009792	embryo development ending in birth or egg hatching	0.0026247518139017245	0.0026247518139017245	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:0043966	histone H3 acetylation	0.0026567548278904757	0.0026567548278904757	+1	BRCA1,SMAD4,BRCA2,SIN3A
GO:2000810	regulation of bicellular tight junction assembly	0.0027235622746606294	0.0027235622746606294	+1	RUNX1,CBFB,MIR142
GO:0072210	metanephric nephron development	0.0027235622746606294	0.0027235622746606294	+1	SOX9,WT1,PDGFRA
GO:0009896	positive regulation of catabolic process	0.00274367986726664	0.00274367986726664	+1	PTEN,APC,FBXW7,KEAP1,NFE2L2,STK11,CEBPA,CDKN1B,LRRK2,TAF1
GO:0001775	cell activation	0.002779727458712512	0.002779727458712512	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,NRAS,IDH1,CEBPA,AKT1,PIK3CG,ATM,TLR4,KIT,PDGFRA,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:1903078	positive regulation of protein localization to plasma membrane	0.002830140533837903	0.002830140533837903	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:0031294	lymphocyte costimulation	0.002830140533837903	0.002830140533837903	+1	PIK3CA,PIK3R1,AKT1,PTPN11
GO:0035050	embryonic heart tube development	0.002830140533837903	0.002830140533837903	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:0014706	striated muscle tissue development	0.0028398938405543453	0.0028398938405543453	+1	NOTCH1,RUNX1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0000302	response to reactive oxygen species	0.0028717589535458997	0.0028717589535458997	+1	EGFR,NFE2L2,AKT1,HGF,LRRK2,PDGFRA
GO:1901216	positive regulation of neuron death	0.0030212465114340557	0.0030212465114340557	+1	NF1,FBXW7,CTNNB1,TLR4
GO:0010827	regulation of glucose transmembrane transport	0.0030212465114340557	0.0030212465114340557	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	0.0030389898463512683	0.0030389898463512683	+1	STK11,EP300,SMAD4
GO:0010332	response to gamma radiation	0.0030389898463512683	0.0030389898463512683	+1	TP53,ATM,ATR
GO:0003148	outflow tract septum morphogenesis	0.0030389898463512683	0.0030389898463512683	+1	FGFR2,SMAD4,TGFBR2
GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus	0.0030389898463512683	0.0030389898463512683	+1	STK11,EP300,SMAD4
GO:1903206	negative regulation of hydrogen peroxide-induced cell death	0.0030389898463512683	0.0030389898463512683	+1	NFE2L2,HGF,LRRK2
GO:0030513	positive regulation of BMP signaling pathway	0.0030389898463512683	0.0030389898463512683	+1	NOTCH1,SMAD4,SMAD2
GO:0090183	regulation of kidney development	0.0030389898463512683	0.0030389898463512683	+1	GATA3,SOX9,WT1
GO:0045931	positive regulation of mitotic cell cycle	0.0030544142995954523	0.0030544142995954523	+1	EGFR,RB1,AKT1,FOXA1,CCND1
GO:2000278	regulation of DNA biosynthetic process	0.0030544142995954523	0.0030544142995954523	+1	TP53,ATM,HGF,CDKN1A,ATR
GO:0043068	positive regulation of programmed cell death	0.003055481157814437	0.003055481157814437	+1	TP53,PTEN,APC,NF1,CDKN2A,NOTCH1,FBXW7,CTNNB1,ATM,LRRK2,FOXA1
GO:0051603	proteolysis involved in cellular protein catabolic process	0.0031859331943218053	0.0031859331943218053	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0045667	regulation of osteoblast differentiation	0.003187386177424362	0.003187386177424362	+1	NOTCH1,SOX9,HGF,FGFR2,ACVR2A
GO:0055017	cardiac muscle tissue growth	0.003187386177424362	0.003187386177424362	+1	NOTCH1,RUNX1,ERBB4,FGFR2
GO:0071560	cellular response to transforming growth factor beta stimulus	0.00322027453255025	0.00322027453255025	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,SMAD2
GO:0030900	forebrain development	0.0033648226611259447	0.0033648226611259447	+1	PTEN,NF1,ERBB4,LRRK2,FGFR2,SIN3A
GO:0000578	embryonic axis specification	0.0033767022145520338	0.0033767022145520338	+1	TBX3,WT1,SMAD2
GO:0045445	myoblast differentiation	0.0033767022145520338	0.0033767022145520338	+1	RB1,NOTCH1,TBX3,SOX9
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	0.0033767022145520338	0.0033767022145520338	+1	TP53,NOTCH1,NFE2L2
GO:1901032	negative regulation of response to reactive oxygen species	0.0033767022145520338	0.0033767022145520338	+1	NFE2L2,HGF,LRRK2
GO:1904888	cranial skeletal system development	0.0033767022145520338	0.0033767022145520338	+1	PDGFRA,FGFR2,TGFBR2
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.0033767022145520338	0.0033767022145520338	+1	FBXW7,NFE2L2,AKT1
GO:0002062	chondrocyte differentiation	0.0033767022145520338	0.0033767022145520338	+1	RUNX1,SOX9,FGFR3,PTPN11
GO:1901723	negative regulation of cell proliferation involved in kidney development	0.0034101004837006127	0.0034101004837006127	+1	GATA3,WT1
GO:1905178	regulation of cardiac muscle tissue regeneration	0.0034101004837006127	0.0034101004837006127	+1	CDKN1B,CDKN1A
GO:0048755	branching morphogenesis of a nerve	0.0034101004837006127	0.0034101004837006127	+1	LRRK2,FGFR2
GO:1905323	telomerase holoenzyme complex assembly	0.0034101004837006127	0.0034101004837006127	+1	ATM,ATR
GO:1900180	regulation of protein localization to nucleus	0.0034101004837006127	0.0034101004837006127	+1	PIK3R1,CDKN2A,CDH1,AKT1,SIN3A
GO:0071599	otic vesicle development	0.0034101004837006127	0.0034101004837006127	+1	SOX9,FGFR2
GO:1905941	positive regulation of gonad development	0.0034101004837006127	0.0034101004837006127	+1	SOX9,WT1
GO:1902498	regulation of protein autoubiquitination	0.0034101004837006127	0.0034101004837006127	+1	LRRK2,TAF1
GO:2000020	positive regulation of male gonad development	0.0034101004837006127	0.0034101004837006127	+1	SOX9,WT1
GO:0006304	DNA modification	0.0034101004837006127	0.0034101004837006127	+1	DNMT3A,WT1,TET2,ATRX,USP9X
GO:2000739	regulation of mesenchymal stem cell differentiation	0.0034101004837006127	0.0034101004837006127	+1	SOX9,PDGFRA
GO:0007435	salivary gland morphogenesis	0.0034101004837006127	0.0034101004837006127	+1	HGF,FGFR2
GO:0008340	determination of adult lifespan	0.0034101004837006127	0.0034101004837006127	+1	TP53,LRRK2
GO:0044262	cellular carbohydrate metabolic process	0.003420122645905884	0.003420122645905884	+1	TP53,PTEN,AKT1,BRAF,EP300,FOXA2,NCOR1
GO:0002768	immune response-regulating cell surface receptor signaling pathway	0.0035091669018209024	0.0035091669018209024	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,MAP2K4,KIT,EP300,CBFB
GO:0006323	DNA packaging	0.00350964026595826	0.00350964026595826	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H2BD
GO:0002764	immune response-regulating signaling pathway	0.0036197857291716358	0.0036197857291716358	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,MAP2K4,KIT,EP300,CBFB
GO:1904892	regulation of receptor signaling pathway via STAT	0.0037006830513628764	0.0037006830513628764	+1	VHL,NOTCH1,ERBB4,KIT,PPP2R1A
GO:0071559	response to transforming growth factor beta	0.0037006830513628764	0.0037006830513628764	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,SMAD2
GO:0044331	cell-cell adhesion mediated by cadherin	0.0037084957457126375	0.0037084957457126375	+1	NOTCH1,FOXA1,FOXA2
GO:2000637	positive regulation of gene silencing by miRNA	0.0037084957457126375	0.0037084957457126375	+1	TP53,EGFR,AJUBA
GO:0001525	angiogenesis	0.003720749682191713	0.003720749682191713	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:2000377	regulation of reactive oxygen species metabolic process	0.0037322823186363165	0.0037322823186363165	+1	TP53,AKT1,TLR4,BRCA1,TGFBR2,CDKN1A
GO:0035270	endocrine system development	0.003742931406669559	0.003742931406669559	+1	NF1,AKT1,WT1,FOXA2
GO:0071103	DNA conformation change	0.003756583871440865	0.003756583871440865	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H2BD,ERCC2
GO:0033157	regulation of intracellular protein transport	0.003772125780587999	0.003772125780587999	+1	TP53,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,LRRK2
GO:0001568	blood vessel development	0.003822268708822669	0.003822268708822669	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0000070	mitotic sister chromatid segregation	0.0038262890935548566	0.0038262890935548566	+1	APC,RB1,ATM,ATRX,SMC1A,RAD21
GO:0022408	negative regulation of cell-cell adhesion	0.0038262890935548566	0.0038262890935548566	+1	CDKN2A,NOTCH1,CDH1,RUNX1,AKT1,CBFB
GO:0010675	regulation of cellular carbohydrate metabolic process	0.0038262890935548566	0.0038262890935548566	+1	TP53,AKT1,EP300,FOXA2,NCOR1
GO:0042063	gliogenesis	0.0038262890935548566	0.0038262890935548566	+1	PTEN,NF1,NOTCH1,SOX9,PRX,MIR142
GO:1902275	regulation of chromatin organization	0.0039489414061777695	0.0039489414061777695	+1	CTNNB1,ATRX,BRCA1,SMAD4,SIN3A,NSD1
GO:1904377	positive regulation of protein localization to cell periphery	0.0039489414061777695	0.0039489414061777695	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:2001022	positive regulation of response to DNA damage stimulus	0.003969195380856022	0.003969195380856022	+1	EGFR,CDKN2A,ATM,BRCA1,ATR
GO:0051225	spindle assembly	0.003969195380856022	0.003969195380856022	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:0046326	positive regulation of glucose import	0.004064394288594725	0.004064394288594725	+1	PIK3R1,AKT1,PTPN11
GO:0060148	positive regulation of posttranscriptional gene silencing	0.004064394288594725	0.004064394288594725	+1	TP53,EGFR,AJUBA
GO:0070199	establishment of protein localization to chromosome	0.004064394288594725	0.004064394288594725	+1	ATM,BRCA2,ATR
GO:0048645	animal organ formation	0.004064394288594725	0.004064394288594725	+1	WT1,FGFR2,SOX17
GO:0071168	protein localization to chromatin	0.004064394288594725	0.004064394288594725	+1	RB1,SETD2,RAD21
GO:1904375	regulation of protein localization to cell periphery	0.004108170522498997	0.004108170522498997	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0031214	biomineral tissue development	0.004108170522498997	0.004108170522498997	+1	NOTCH1,SOX9,FGFR2,FGFR3,ACVR2A
GO:0110148	biomineralization	0.004108170522498997	0.004108170522498997	+1	NOTCH1,SOX9,FGFR2,FGFR3,ACVR2A
GO:0048565	digestive tract development	0.004152782400959854	0.004152782400959854	+1	KIT,PDGFRA,FGFR2,SOX17
GO:0061136	regulation of proteasomal protein catabolic process	0.004163061197913943	0.004163061197913943	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0045184	establishment of protein localization	0.004223929291388321	0.004223929291388321	+1	TP53,EGFR,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,NPM1,IDH1,RPL22,AKT1,BRAF,ATM,TLR4,U2AF1,LRRK2,SETD2,FOXA2,USP9X,BRCA2,ATR,RPL5
GO:0018107	peptidyl-threonine phosphorylation	0.004268751958061665	0.004268751958061665	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
GO:0007017	microtubule-based process	0.004443231973796771	0.004443231973796771	+1	APC,NAV3,CTNNB1,NPM1,STK11,EPHA3,STAG2,BRCA1,CHEK2,SETD2,BRCA2,SMC1A,SMC3,NCOR1
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	0.004443231973796771	0.004443231973796771	+1	TP53,VHL,NOTCH1,NFE2L2,EP300
GO:0061647	histone H3-K9 modification	0.004465220185591	0.004465220185591	+1	ATRX,BRCA1,SMAD4
GO:0060045	positive regulation of cardiac muscle cell proliferation	0.004465220185591	0.004465220185591	+1	NOTCH1,ERBB4,FGFR2
GO:0071364	cellular response to epidermal growth factor stimulus	0.004465220185591	0.004465220185591	+1	EGFR,SOX9,PTPN11
GO:1903205	regulation of hydrogen peroxide-induced cell death	0.004465220185591	0.004465220185591	+1	NFE2L2,HGF,LRRK2
GO:0090394	negative regulation of excitatory postsynaptic potential	0.004489308005515672	0.004489308005515672	+1	PTEN,LRRK2
GO:0007431	salivary gland development	0.004489308005515672	0.004489308005515672	+1	HGF,FGFR2
GO:0071371	cellular response to gonadotropin stimulus	0.004489308005515672	0.004489308005515672	+1	NOTCH1,WT1
GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation	0.004489308005515672	0.004489308005515672	+1	RUNX1,CBFB
GO:0071481	cellular response to X-ray	0.004489308005515672	0.004489308005515672	+1	GATA3,ATM
GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	0.004489308005515672	0.004489308005515672	+1	NOTCH1,TGFBR2
GO:0060602	branch elongation of an epithelium	0.004489308005515672	0.004489308005515672	+1	SOX9,FGFR2
GO:0003190	atrioventricular valve formation	0.004489308005515672	0.004489308005515672	+1	NOTCH1,SMAD4
GO:0003376	sphingosine-1-phosphate receptor signaling pathway	0.004489308005515672	0.004489308005515672	+1	AKT1,PIK3CG
GO:2000018	regulation of male gonad development	0.004489308005515672	0.004489308005515672	+1	SOX9,WT1
GO:0090520	sphingolipid mediated signaling pathway	0.004489308005515672	0.004489308005515672	+1	AKT1,PIK3CG
GO:0048715	negative regulation of oligodendrocyte differentiation	0.004489308005515672	0.004489308005515672	+1	NF1,NOTCH1
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	0.0045742919877294185	0.0045742919877294185	+1	FLT3,ERBB4,KIT,FGFR3
GO:0055123	digestive system development	0.0045742919877294185	0.0045742919877294185	+1	KIT,PDGFRA,FGFR2,SOX17
GO:0044070	regulation of anion transport	0.004618501557941065	0.004618501557941065	+1	TP53,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,AKT1,BRAF,TLR4,LRRK2,SETD2,FOXA2,PTPN11
GO:0034622	cellular protein-containing complex assembly	0.0046686758762398564	0.0046686758762398564	+1	TP53,NAV3,RB1,NPM1,SOX9,ATM,TLR4,ATRX,SMAD4,SF3B1,TAF1,ATR,HIST1H2BD,RPL5,SMAD2,ERCC2
GO:0045580	regulation of T cell differentiation	0.0047210573138228365	0.0047210573138228365	+1	CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:0044248	cellular catabolic process	0.0048009414911469005	0.0048009414911469005	+1	TP53,PIK3CA,PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,RPL22,STK11,CEBPA,AKT1,ATM,HGF,MTOR,TET2,LRRK2,CHEK2,EP300,USP9X,TAF1,PPP2R1A,TBL1XR1,RPL5,SPOP,AXIN2
GO:0045582	positive regulation of T cell differentiation	0.0048169216792942355	0.0048169216792942355	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0072009	nephron epithelium development	0.0048169216792942355	0.0048169216792942355	+1	GATA3,CTNNB1,SOX9,WT1
GO:0090307	mitotic spindle assembly	0.0048169216792942355	0.0048169216792942355	+1	STAG2,CHEK2,SMC1A,SMC3
GO:1902883	negative regulation of response to oxidative stress	0.004829924227192309	0.004829924227192309	+1	NFE2L2,HGF,LRRK2
GO:0003203	endocardial cushion morphogenesis	0.004829924227192309	0.004829924227192309	+1	NOTCH1,SOX9,TGFBR2
GO:0048483	autonomic nervous system development	0.004829924227192309	0.004829924227192309	+1	NF1,GATA3,CTNNB1
GO:0006629	lipid metabolic process	0.004852245902307417	0.004852245902307417	+1	PIK3CA,PTEN,PIK3R1,FBXW7,FLT3,AKT1,PIK3CG,SOX9,ERBB4,MTOR,BRCA1,KIT,PDGFRA,FGFR3,B4GALT3,PPP2R1A,SIN3A,TBL1XR1,NCOR1
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.004871760515363877	0.004871760515363877	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
GO:0031334	positive regulation of protein-containing complex assembly	0.004897506266957389	0.004897506266957389	+1	TP53,NAV3,AJUBA,ATM,TLR4,ATR,ERCC2
GO:1903131	mononuclear cell differentiation	0.004964781373132222	0.004964781373132222	+1	CDKN2A,GATA3,FLT3,RUNX1,ATM,KIT,TGFBR2,CBFB
GO:1905475	regulation of protein localization to membrane	0.005007350995852038	0.005007350995852038	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0035148	tube formation	0.005046411911157238	0.005046411911157238	+1	GATA3,NOTCH1,SOX9,FGFR2
GO:1905477	positive regulation of protein localization to membrane	0.005046411911157238	0.005046411911157238	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1
GO:0032526	response to retinoic acid	0.005046411911157238	0.005046411911157238	+1	EPHA3,SOX9,ATM,ASXL1
GO:0072593	reactive oxygen species metabolic process	0.005122430857098402	0.005122430857098402	+1	TP53,AKT1,TLR4,BRCA1,LRRK2,TGFBR2,CDKN1A
GO:0051236	establishment of RNA localization	0.00513325381226838	0.00513325381226838	+1	NPM1,ATM,U2AF1,SETD2,TGFBR2,ATR
GO:0001649	osteoblast differentiation	0.00513325381226838	0.00513325381226838	+1	NF1,NOTCH1,SOX9,HGF,FGFR2,ACVR2A
GO:0042330	taxis	0.005153272467761098	0.005153272467761098	+1	PIK3CA,PIK3R1,NOTCH1,ARHGAP35,EPHA3,PIK3CG,HGF,KIT,PDGFRA,PTPN11,EGR3
GO:0006935	chemotaxis	0.005153272467761098	0.005153272467761098	+1	PIK3CA,PIK3R1,NOTCH1,ARHGAP35,EPHA3,PIK3CG,HGF,KIT,PDGFRA,PTPN11,EGR3
GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	0.0052146626851931905	0.0052146626851931905	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
GO:0043525	positive regulation of neuron apoptotic process	0.005245291888320094	0.005245291888320094	+1	NF1,FBXW7,CTNNB1
GO:1904837	beta-catenin-TCF complex assembly	0.005245291888320094	0.005245291888320094	+1	CTNNB1,EP300,AXIN2
GO:0010837	regulation of keratinocyte proliferation	0.005245291888320094	0.005245291888320094	+1	EPPK1,TLR4,FGFR2
GO:0048640	negative regulation of developmental growth	0.0052768572442399905	0.0052768572442399905	+1	PTEN,CDKN1B,FGFR3,CDKN1A
GO:0090398	cellular senescence	0.0052768572442399905	0.0052768572442399905	+1	TP53,CDKN2A,TBX3,CDKN1A
GO:0043583	ear development	0.0052768572442399905	0.0052768572442399905	+1	GATA3,SOX9,FGFR2,PTPN11
GO:0061041	regulation of wound healing	0.005375440918468795	0.005375440918468795	+1	PTEN,EPPK1,MTOR,PDGFRA,FOXA2
GO:0043620	regulation of DNA-templated transcription in response to stress	0.005375440918468795	0.005375440918468795	+1	TP53,VHL,NOTCH1,NFE2L2,EP300
GO:0008286	insulin receptor signaling pathway	0.005375440918468795	0.005375440918468795	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0006913	nucleocytoplasmic transport	0.005535480780441793	0.005535480780441793	+1	TP53,PIK3R1,CDKN2A,CDH1,NPM1,AKT1,U2AF1,SETD2
GO:0021782	glial cell development	0.005552824180434446	0.005552824180434446	+1	PTEN,NF1,PRX,MIR142
GO:0070661	leukocyte proliferation	0.005566525556565592	0.005566525556565592	+1	CDKN2A,FLT3,PIK3CG,ATM,KIT,TGFBR2,MAPK8IP1
GO:0008637	apoptotic mitochondrial changes	0.005567664495369315	0.005567664495369315	+1	TP53,CDKN2A,AKT1,HGF,ERBB4
GO:0002327	immature B cell differentiation	0.005584023163223576	0.005584023163223576	+1	ATM,KIT
GO:0043970	histone H3-K9 acetylation	0.005584023163223576	0.005584023163223576	+1	BRCA1,SMAD4
GO:0090400	stress-induced premature senescence	0.005584023163223576	0.005584023163223576	+1	TP53,CDKN1A
GO:0036302	atrioventricular canal development	0.005584023163223576	0.005584023163223576	+1	SMAD4,PTPN11
GO:0072239	metanephric glomerulus vasculature development	0.005584023163223576	0.005584023163223576	+1	WT1,PDGFRA
GO:0010259	multicellular organism aging	0.005584023163223576	0.005584023163223576	+1	TP53,LRRK2
GO:0060644	mammary gland epithelial cell differentiation	0.005584023163223576	0.005584023163223576	+1	AKT1,ERBB4
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	0.005584023163223576	0.005584023163223576	+1	PIK3CA,PIK3CG
GO:0060675	ureteric bud morphogenesis	0.005584023163223576	0.005584023163223576	+1	GATA3,SOX9,WT1
GO:0072497	mesenchymal stem cell differentiation	0.005584023163223576	0.005584023163223576	+1	SOX9,PDGFRA
GO:0070849	response to epidermal growth factor	0.005584023163223576	0.005584023163223576	+1	EGFR,SOX9,PTPN11
GO:0034698	response to gonadotropin	0.005584023163223576	0.005584023163223576	+1	NOTCH1,WT1
GO:0030217	T cell differentiation	0.005584023163223576	0.005584023163223576	+1	CDKN2A,GATA3,RUNX1,KIT,TGFBR2,CBFB
GO:0032071	regulation of endodeoxyribonuclease activity	0.005584023163223576	0.005584023163223576	+1	NPM1,AKT1
GO:0032101	regulation of response to external stimulus	0.005584023163223576	0.005584023163223576	+1	PTEN,KRAS,GATA3,RB1,NOTCH1,NRAS,CEBPA,EPPK1,TLR4,PDGFRA,EP300,FOXA2,SIN3A,PTPN11,MIR142
GO:0048711	positive regulation of astrocyte differentiation	0.005584023163223576	0.005584023163223576	+1	NOTCH1,MIR142
GO:2000615	regulation of histone H3-K9 acetylation	0.005584023163223576	0.005584023163223576	+1	BRCA1,SMAD4
GO:0006975	DNA damage induced protein phosphorylation	0.005584023163223576	0.005584023163223576	+1	ATM,CHEK2
GO:0033599	regulation of mammary gland epithelial cell proliferation	0.005584023163223576	0.005584023163223576	+1	GATA3,BRCA2
GO:0071493	cellular response to UV-B	0.005584023163223576	0.005584023163223576	+1	STK11,CDKN1A
GO:1905634	regulation of protein localization to chromatin	0.005584023163223576	0.005584023163223576	+1	RB1,SETD2
GO:1905939	regulation of gonad development	0.005584023163223576	0.005584023163223576	+1	SOX9,WT1
GO:0071542	dopaminergic neuron differentiation	0.005584023163223576	0.005584023163223576	+1	CTNNB1,FOXA1,FOXA2
GO:0062042	regulation of cardiac epithelial to mesenchymal transition	0.005584023163223576	0.005584023163223576	+1	NOTCH1,TGFBR2
GO:0018210	peptidyl-threonine modification	0.0056328998273801716	0.0056328998273801716	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0056328998273801716	0.0056328998273801716	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0003158	endothelium development	0.0056328998273801716	0.0056328998273801716	+1	NOTCH1,CTNNB1,SMAD4,SOX17,VEZF1
GO:1903793	positive regulation of anion transport	0.00567673805692003	0.00567673805692003	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,AKT1,BRAF,TLR4,PTPN11
GO:0051169	nuclear transport	0.005705642397948165	0.005705642397948165	+1	TP53,PIK3R1,CDKN2A,CDH1,NPM1,AKT1,U2AF1,SETD2
GO:0051251	positive regulation of lymphocyte activation	0.005705642397948165	0.005705642397948165	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0045927	positive regulation of growth	0.005864955554535467	0.005864955554535467	+1	EGFR,NOTCH1,AKT1,WT1,ERBB4,FGFR2
GO:0031668	cellular response to extracellular stimulus	0.005864955554535467	0.005864955554535467	+1	TP53,ARHGAP35,MTOR,LRRK2,FOXA2,CDKN1A
GO:1903747	regulation of establishment of protein localization to mitochondrion	0.005980949502323851	0.005980949502323851	+1	TP53,FBXW7,BAP1,LRRK2
GO:0006739	NADP metabolic process	0.006019350785199752	0.006019350785199752	+1	TP53,IDH1,IDH2
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	0.006019350785199752	0.006019350785199752	+1	CDKN2A,ATM,ATR
GO:0097191	extrinsic apoptotic signaling pathway	0.006019350785199752	0.006019350785199752	+1	PTEN,AKT1,AR,BRCA1,FGFR3,ACVR1B
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	0.006019350785199752	0.006019350785199752	+1	TP53,GATA3,WT1
GO:0090505	epiboly involved in wound healing	0.006019350785199752	0.006019350785199752	+1	PTEN,ARHGAP35,MTOR
GO:0036474	cell death in response to hydrogen peroxide	0.006019350785199752	0.006019350785199752	+1	NFE2L2,HGF,LRRK2
GO:0044319	wound healing, spreading of cells	0.006019350785199752	0.006019350785199752	+1	PTEN,ARHGAP35,MTOR
GO:0009948	anterior/posterior axis specification	0.006019350785199752	0.006019350785199752	+1	TBX3,WT1,FOXA2
GO:0055023	positive regulation of cardiac muscle tissue growth	0.006019350785199752	0.006019350785199752	+1	NOTCH1,ERBB4,FGFR2
GO:0007596	blood coagulation	0.006123104252690936	0.006123104252690936	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,TLR4,PDGFRA,FOXA2,PTPN11
GO:0051336	regulation of hydrolase activity	0.006155893796954552	0.006155893796954552	+1	TP53,EGFR,NF1,CDKN2A,NPM1,EPHA3,AKT1,HGF,MTOR,LRRK2,KIT,PDGFRA,FGFR2,FGFR3,EZH2
GO:0016573	histone acetylation	0.006203227890497445	0.006203227890497445	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:1900182	positive regulation of protein localization to nucleus	0.006228996955594175	0.006228996955594175	+1	PIK3R1,CDKN2A,CDH1,AKT1
GO:0006310	DNA recombination	0.006448525198200074	0.006448525198200074	+1	ATM,BRCA1,POLQ,SETD2,BRCA2,RAD21,ERCC2
GO:0055010	ventricular cardiac muscle tissue morphogenesis	0.006504377087928826	0.006504377087928826	+1	NOTCH1,FGFR2,SMAD4
GO:0090504	epiboly	0.006504377087928826	0.006504377087928826	+1	PTEN,ARHGAP35,MTOR
GO:0045746	negative regulation of Notch signaling pathway	0.006504377087928826	0.006504377087928826	+1	EGFR,FBXW7,AKT1
GO:1901031	regulation of response to reactive oxygen species	0.006504377087928826	0.006504377087928826	+1	NFE2L2,HGF,LRRK2
GO:0031572	G2 DNA damage checkpoint	0.006504377087928826	0.006504377087928826	+1	ATM,BRCA1,CDKN1A
GO:0031062	positive regulation of histone methylation	0.006504377087928826	0.006504377087928826	+1	CTNNB1,BRCA1,SMAD4
GO:0072171	mesonephric tubule morphogenesis	0.006504377087928826	0.006504377087928826	+1	GATA3,SOX9,WT1
GO:0008585	female gonad development	0.006504377087928826	0.006504377087928826	+1	WT1,KIT,PDGFRA
GO:0007599	hemostasis	0.0065629533642233215	0.0065629533642233215	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,TLR4,PDGFRA,FOXA2,PTPN11
GO:0048660	regulation of smooth muscle cell proliferation	0.006597619699465225	0.006597619699465225	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:0009408	response to heat	0.006597619699465225	0.006597619699465225	+1	AKT1,ATM,MTOR,EP300,ATR
GO:0007179	transforming growth factor beta receptor signaling pathway	0.0066091145087782315	0.0066091145087782315	+1	STK11,EP300,SMAD4,USP9X,TGFBR2,SMAD2
GO:0050817	coagulation	0.006671681658333141	0.006671681658333141	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,TLR4,PDGFRA,FOXA2,PTPN11
GO:0033135	regulation of peptidyl-serine phosphorylation	0.006804101595624215	0.006804101595624215	+1	PTEN,EGFR,AKT1,BRAF,NSD1
GO:0032479	regulation of type I interferon production	0.006804101595624215	0.006804101595624215	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:0031397	negative regulation of protein ubiquitination	0.006804101595624215	0.006804101595624215	+1	CDKN2A,AKT1,TAF1,RPL5
GO:0018393	internal peptidyl-lysine acetylation	0.006804101595624215	0.006804101595624215	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0035520	monoubiquitinated protein deubiquitination	0.006807051757590207	0.006807051757590207	+1	BAP1,ASXL1
GO:0046322	negative regulation of fatty acid oxidation	0.006807051757590207	0.006807051757590207	+1	AKT1,SOX9
GO:0048557	embryonic digestive tract morphogenesis	0.006807051757590207	0.006807051757590207	+1	PDGFRA,FGFR2
GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	0.006807051757590207	0.006807051757590207	+1	RUNX1,CBFB
GO:0003416	endochondral bone growth	0.006807051757590207	0.006807051757590207	+1	SOX9,FGFR3
GO:0043065	positive regulation of apoptotic process	0.006807051757590207	0.006807051757590207	+1	TP53,PTEN,APC,NF1,CDKN2A,NOTCH1,FBXW7,CTNNB1,ATM,FOXA1
GO:0002328	pro-B cell differentiation	0.006807051757590207	0.006807051757590207	+1	NOTCH1,FLT3
GO:1903689	regulation of wound healing, spreading of epidermal cells	0.006807051757590207	0.006807051757590207	+1	PTEN,MTOR
GO:0072079	nephron tubule formation	0.006807051757590207	0.006807051757590207	+1	GATA3,SOX9
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	0.006807051757590207	0.006807051757590207	+1	FOXA1,FOXA2
GO:0070102	interleukin-6-mediated signaling pathway	0.006949312470977472	0.006949312470977472	+1	CEBPA,SMAD4,PTPN11
GO:0035850	epithelial cell differentiation involved in kidney development	0.006949312470977472	0.006949312470977472	+1	GATA3,CTNNB1,WT1
GO:0046545	development of primary female sexual characteristics	0.006949312470977472	0.006949312470977472	+1	WT1,KIT,PDGFRA
GO:0032606	type I interferon production	0.006955188727258973	0.006955188727258973	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:0048659	smooth muscle cell proliferation	0.006955188727258973	0.006955188727258973	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:1901992	positive regulation of mitotic cell cycle phase transition	0.007027812523772627	0.007027812523772627	+1	EGFR,RB1,AKT1,CCND1
GO:0061351	neural precursor cell proliferation	0.007027812523772627	0.007027812523772627	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:0070830	bicellular tight junction assembly	0.007027812523772627	0.007027812523772627	+1	APC,RUNX1,CBFB,MIR142
GO:0044344	cellular response to fibroblast growth factor stimulus	0.007161941137411311	0.007161941137411311	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:0006475	internal protein amino acid acetylation	0.007161941137411311	0.007161941137411311	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0000086	G2/M transition of mitotic cell cycle	0.007161941137411311	0.007161941137411311	+1	CDKN2A,AJUBA,ATM,CHEK2,CCND1,CDKN1A,PPP2R1A
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	0.007161941137411311	0.007161941137411311	+1	PTEN,CDKN2A,FBXW7,BRCA1,LRRK2
GO:0045661	regulation of myoblast differentiation	0.007469738103965848	0.007469738103965848	+1	NOTCH1,TBX3,SOX9
GO:0003197	endocardial cushion development	0.007469738103965848	0.007469738103965848	+1	NOTCH1,SOX9,TGFBR2
GO:0002683	negative regulation of immune system process	0.007469738103965848	0.007469738103965848	+1	CDKN2A,FBXW7,RUNX1,AKT1,SOX9,ATM,TLR4,CBFB
GO:0003229	ventricular cardiac muscle tissue development	0.007469738103965848	0.007469738103965848	+1	NOTCH1,FGFR2,SMAD4
GO:0006282	regulation of DNA repair	0.007643946496082065	0.007643946496082065	+1	EGFR,BRCA1,POLQ,SETD2,AXIN2
GO:0071774	response to fibroblast growth factor	0.007643946496082065	0.007643946496082065	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:0030278	regulation of ossification	0.007669036359700999	0.007669036359700999	+1	NOTCH1,SOX9,PTPN11,ACVR2A
GO:0120192	tight junction assembly	0.007669036359700999	0.007669036359700999	+1	APC,RUNX1,CBFB,MIR142
GO:0045621	positive regulation of lymphocyte differentiation	0.007669036359700999	0.007669036359700999	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0045216	cell-cell junction organization	0.007762938820315911	0.007762938820315911	+1	APC,CTNNB1,CDH1,RUNX1,CBFB,MIR142
GO:2000146	negative regulation of cell motility	0.007855260431420805	0.007855260431420805	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.00801688088618119	0.00801688088618119	+1	VHL,NOTCH1,NFE2L2,EP300
GO:0032924	activin receptor signaling pathway	0.00801688088618119	0.00801688088618119	+1	ACVR1B,ACVR2A,SMAD2
GO:0046329	negative regulation of JNK cascade	0.00801688088618119	0.00801688088618119	+1	MAPK8IP1,MECOM,NCOR1
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	0.00801688088618119	0.00801688088618119	+1	EGFR,AKT1,CCND1
GO:0035924	cellular response to vascular endothelial growth factor stimulus	0.00801688088618119	0.00801688088618119	+1	PIK3CA,NOTCH1,PDGFRA,EGR3
GO:0051100	negative regulation of binding	0.008110271804363297	0.008110271804363297	+1	AKT1,LRRK2,CDKN1A,TAF1,SIN3A
GO:0007183	SMAD protein complex assembly	0.008167044004089786	0.008167044004089786	+1	SMAD4,SMAD2
GO:0043374	CD8-positive, alpha-beta T cell differentiation	0.008167044004089786	0.008167044004089786	+1	RUNX1,CBFB
GO:0060443	mammary gland morphogenesis	0.008167044004089786	0.008167044004089786	+1	ELF3,FGFR2
GO:1901722	regulation of cell proliferation involved in kidney development	0.008167044004089786	0.008167044004089786	+1	GATA3,WT1
GO:0050878	regulation of body fluid levels	0.008167044004089786	0.008167044004089786	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,ERBB4,TLR4,PDGFRA,FOXA2,PTPN11
GO:1904667	negative regulation of ubiquitin protein ligase activity	0.008167044004089786	0.008167044004089786	+1	CDKN2A,RPL5
GO:0072182	regulation of nephron tubule epithelial cell differentiation	0.008167044004089786	0.008167044004089786	+1	GATA3,CTNNB1
GO:0032070	regulation of deoxyribonuclease activity	0.008167044004089786	0.008167044004089786	+1	NPM1,AKT1
GO:0033598	mammary gland epithelial cell proliferation	0.008167044004089786	0.008167044004089786	+1	GATA3,BRCA2
GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	0.008167044004089786	0.008167044004089786	+1	TP53,EGFR
GO:0007162	negative regulation of cell adhesion	0.008170754602337255	0.008170754602337255	+1	PTEN,CDKN2A,NOTCH1,CDH1,RUNX1,AKT1,CBFB
GO:0045862	positive regulation of proteolysis	0.008186729308999606	0.008186729308999606	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0030509	BMP signaling pathway	0.008278050993642119	0.008278050993642119	+1	NOTCH1,SMAD4,USP9X,ACVR2A,SMAD2
GO:0045619	regulation of lymphocyte differentiation	0.008278050993642119	0.008278050993642119	+1	CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:0120193	tight junction organization	0.008278050993642119	0.008278050993642119	+1	APC,RUNX1,CBFB,MIR142
GO:0002684	positive regulation of immune system process	0.008452305175823956	0.008452305175823956	+1	PIK3CA,KRAS,PIK3R1,GATA3,RUNX1,NRAS,CEBPA,AKT1,TLR4,EP300,TGFBR2,CBFB,SIN3A,PTPN11,MIR142
GO:0045581	negative regulation of T cell differentiation	0.008452732724657819	0.008452732724657819	+1	CDKN2A,RUNX1,CBFB
GO:0120036	plasma membrane bounded cell projection organization	0.008452732724657819	0.008452732724657819	+1	PIK3CA,PTEN,APC,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,KIT,EP300,FGFR2,USP9X,PPP2R1A,SIN3A,PTPN11
GO:1902116	negative regulation of organelle assembly	0.008452732724657819	0.008452732724657819	+1	BRCA1,LRRK2,SMAD4
GO:0060021	roof of mouth development	0.008452732724657819	0.008452732724657819	+1	SMAD4,TGFBR2,SMAD2
GO:0072078	nephron tubule morphogenesis	0.008452732724657819	0.008452732724657819	+1	GATA3,SOX9,WT1
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	0.008452732724657819	0.008452732724657819	+1	FBXW7,NFE2L2,AKT1
GO:0045685	regulation of glial cell differentiation	0.008452732724657819	0.008452732724657819	+1	NF1,NOTCH1,MIR142
GO:0043616	keratinocyte proliferation	0.008452732724657819	0.008452732724657819	+1	EPPK1,TLR4,FGFR2
GO:0046638	positive regulation of alpha-beta T cell differentiation	0.008452732724657819	0.008452732724657819	+1	RUNX1,TGFBR2,CBFB
GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	0.008452732724657819	0.008452732724657819	+1	PTEN,CDKN1B,CDKN1A
GO:0001816	cytokine production	0.008452732724657819	0.008452732724657819	+1	NAV3,GATA3,CTNNB1,RUNX1,PIK3CG,TLR4,BRCA1,KIT,SETD2,EP300,SMAD4,PTPN11,MIR142
GO:0010677	negative regulation of cellular carbohydrate metabolic process	0.008452732724657819	0.008452732724657819	+1	EP300,FOXA2,NCOR1
GO:0018394	peptidyl-lysine acetylation	0.008455820197351176	0.008455820197351176	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0051271	negative regulation of cellular component movement	0.008528497101992738	0.008528497101992738	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1
GO:1904659	glucose transmembrane transport	0.008544400013758613	0.008544400013758613	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0060284	regulation of cell development	0.008675749858152922	0.008675749858152922	+1	PTEN,NF1,NOTCH1,FBXW7,CTNNB1,LRRK2,SMAD4,MIR142
GO:0022603	regulation of anatomical structure morphogenesis	0.008703733345651313	0.008703733345651313	+1	PTEN,NF1,GATA3,CTNNB1,ARHGAP35,RUNX1,SOX9,WT1,HGF,BRCA1,LRRK2,KIT,FGFR2,FOXA2
GO:0051147	regulation of muscle cell differentiation	0.008705688206256019	0.008705688206256019	+1	NOTCH1,CTNNB1,KIT,FGFR2,SMAD4
GO:0006302	double-strand break repair	0.008910641169162273	0.008910641169162273	+1	ATM,BRCA1,POLQ,CHEK2,SETD2,BRCA2,RAD21
GO:0045652	regulation of megakaryocyte differentiation	0.008910641169162273	0.008910641169162273	+1	RUNX1,EP300,CBFB,SIN3A
GO:1900034	regulation of cellular response to heat	0.008910641169162273	0.008910641169162273	+1	ATM,MTOR,EP300,ATR
GO:1905330	regulation of morphogenesis of an epithelium	0.009024369188215121	0.009024369188215121	+1	GATA3,SOX9,HGF
GO:0060349	bone morphogenesis	0.009024369188215121	0.009024369188215121	+1	SOX9,FGFR2,FGFR3
GO:0031648	protein destabilization	0.009024369188215121	0.009024369188215121	+1	CDKN2A,EP300,SOX17
GO:0061005	cell differentiation involved in kidney development	0.009024369188215121	0.009024369188215121	+1	GATA3,CTNNB1,WT1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	0.00920143631076762	0.00920143631076762	+1	FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,TBL1XR1,SPOP
GO:1903034	regulation of response to wounding	0.009228152033431776	0.009228152033431776	+1	PTEN,EPPK1,MTOR,PDGFRA,FOXA2
GO:0002761	regulation of myeloid leukocyte differentiation	0.009238542196806518	0.009238542196806518	+1	FBXW7,RUNX1,MTOR,TLR4
GO:0090287	regulation of cellular response to growth factor stimulus	0.009238542196806518	0.009238542196806518	+1	GATA3,NOTCH1,STK11,EP300,SMAD4,TGFBR2,SMAD2
GO:0046634	regulation of alpha-beta T cell activation	0.009238542196806518	0.009238542196806518	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:0043297	apical junction assembly	0.009238542196806518	0.009238542196806518	+1	APC,RUNX1,CBFB,MIR142
GO:1901214	regulation of neuron death	0.009378245405903604	0.009378245405903604	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
GO:0007423	sensory organ development	0.009406384125784586	0.009406384125784586	+1	NF1,GATA3,SOX9,WT1,PDGFRA,FGFR2,PTPN11
GO:0060968	regulation of gene silencing	0.009467716005602745	0.009467716005602745	+1	TP53,EGFR,AJUBA,SIN3A,NCOR1
GO:0000724	double-strand break repair via homologous recombination	0.009467716005602745	0.009467716005602745	+1	BRCA1,POLQ,SETD2,BRCA2,RAD21
GO:0060039	pericardium development	0.009467783276650736	0.009467783276650736	+1	NOTCH1,WT1
GO:0010826	negative regulation of centrosome duplication	0.009467783276650736	0.009467783276650736	+1	NPM1,BRCA1
GO:0046606	negative regulation of centrosome cycle	0.009467783276650736	0.009467783276650736	+1	NPM1,BRCA1
GO:0030325	adrenal gland development	0.009467783276650736	0.009467783276650736	+1	NF1,WT1
GO:2000434	regulation of protein neddylation	0.009467783276650736	0.009467783276650736	+1	CDKN2A,RPL5
GO:0035272	exocrine system development	0.009467783276650736	0.009467783276650736	+1	HGF,FGFR2
GO:0030850	prostate gland development	0.009467783276650736	0.009467783276650736	+1	SOX9,FGFR2
GO:0030030	cell projection organization	0.009467783276650736	0.009467783276650736	+1	PIK3CA,PTEN,APC,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,KIT,EP300,FGFR2,USP9X,PPP2R1A,SIN3A,PTPN11
GO:0033262	regulation of nuclear cell cycle DNA replication	0.009467783276650736	0.009467783276650736	+1	ATRX,CHEK2
GO:0003188	heart valve formation	0.009467783276650736	0.009467783276650736	+1	NOTCH1,SMAD4
GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	0.009467783276650736	0.009467783276650736	+1	AKT1,TLR4
GO:0098868	bone growth	0.009467783276650736	0.009467783276650736	+1	SOX9,FGFR3
GO:0003401	axis elongation	0.009467783276650736	0.009467783276650736	+1	SOX9,FGFR2
GO:0072028	nephron morphogenesis	0.009481413841108349	0.009481413841108349	+1	GATA3,SOX9,WT1
GO:0031297	replication fork processing	0.009481413841108349	0.009481413841108349	+1	ATRX,BRCA2,ATR
GO:1903053	regulation of extracellular matrix organization	0.009481413841108349	0.009481413841108349	+1	RB1,NOTCH1,RUNX1
GO:0046854	phosphatidylinositol phosphorylation	0.009481413841108349	0.009481413841108349	+1	PIK3CA,PIK3R1,PIK3CG
GO:0045912	negative regulation of carbohydrate metabolic process	0.009481413841108349	0.009481413841108349	+1	EP300,FOXA2,NCOR1
GO:0072088	nephron epithelium morphogenesis	0.009481413841108349	0.009481413841108349	+1	GATA3,SOX9,WT1
GO:0072655	establishment of protein localization to mitochondrion	0.009601856451512148	0.009601856451512148	+1	TP53,FBXW7,BAP1,AKT1,LRRK2
GO:0000725	recombinational repair	0.009601856451512148	0.009601856451512148	+1	BRCA1,POLQ,SETD2,BRCA2,RAD21
GO:0032388	positive regulation of intracellular transport	0.009898250337077183	0.009898250337077183	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,STK11
GO:2001242	regulation of intrinsic apoptotic signaling pathway	0.009898250337077183	0.009898250337077183	+1	TP53,FBXW7,NFE2L2,AKT1,LRRK2
GO:0042692	muscle cell differentiation	0.01001021130353076	0.01001021130353076	+1	NOTCH1,CTNNB1,WT1,KIT,PDGFRA,FGFR2,SMAD4
GO:0048708	astrocyte differentiation	0.010118413202224383	0.010118413202224383	+1	NF1,NOTCH1,MIR142
GO:0021954	central nervous system neuron development	0.010118413202224383	0.010118413202224383	+1	PTEN,ARHGAP35,FGFR2
GO:0018023	peptidyl-lysine trimethylation	0.010118413202224383	0.010118413202224383	+1	TET2,ATRX,SETD2
GO:0061333	renal tubule morphogenesis	0.010118413202224383	0.010118413202224383	+1	GATA3,SOX9,WT1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	0.010165862438420284	0.010165862438420284	+1	STAG2,CHEK2,SETD2,SMC1A,SMC3
GO:0060218	hematopoietic stem cell differentiation	0.010243151180511709	0.010243151180511709	+1	TP53,GATA3,RUNX1,CBFB
GO:1903959	regulation of anion transmembrane transport	0.010243151180511709	0.010243151180511709	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:1902904	negative regulation of supramolecular fiber organization	0.010438088207204314	0.010438088207204314	+1	PIK3CA,APC,NAV3,PIK3R1,SMAD4
GO:0090263	positive regulation of canonical Wnt signaling pathway	0.010438088207204314	0.010438088207204314	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
GO:0007043	cell-cell junction assembly	0.010438088207204314	0.010438088207204314	+1	APC,CTNNB1,RUNX1,CBFB,MIR142
GO:0070585	protein localization to mitochondrion	0.010438088207204314	0.010438088207204314	+1	TP53,FBXW7,BAP1,AKT1,LRRK2
GO:0008645	hexose transmembrane transport	0.010651275809668676	0.010651275809668676	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0031331	positive regulation of cellular catabolic process	0.010681761805680432	0.010681761805680432	+1	PTEN,FBXW7,KEAP1,NFE2L2,STK11,CEBPA,LRRK2,TAF1
GO:0045670	regulation of osteoclast differentiation	0.010731738007791446	0.010731738007791446	+1	FBXW7,MTOR,TLR4
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	0.010731738007791446	0.010731738007791446	+1	NOTCH1,ERBB4,KIT
GO:0045620	negative regulation of lymphocyte differentiation	0.010731738007791446	0.010731738007791446	+1	CDKN2A,RUNX1,CBFB
GO:1903214	regulation of protein targeting to mitochondrion	0.010731738007791446	0.010731738007791446	+1	FBXW7,BAP1,LRRK2
GO:0035065	regulation of histone acetylation	0.010731738007791446	0.010731738007791446	+1	BRCA1,SMAD4,SIN3A
GO:0006403	RNA localization	0.010751262177549377	0.010751262177549377	+1	NPM1,ATM,U2AF1,SETD2,TGFBR2,ATR
GO:0072160	nephron tubule epithelial cell differentiation	0.010863412015145226	0.010863412015145226	+1	GATA3,CTNNB1
GO:0072224	metanephric glomerulus development	0.010863412015145226	0.010863412015145226	+1	WT1,PDGFRA
GO:0043217	myelin maintenance	0.010863412015145226	0.010863412015145226	+1	PTEN,PRX
GO:0022011	myelination in peripheral nervous system	0.010863412015145226	0.010863412015145226	+1	NF1,PRX
GO:0014044	Schwann cell development	0.010863412015145226	0.010863412015145226	+1	NF1,PRX
GO:0035988	chondrocyte proliferation	0.010863412015145226	0.010863412015145226	+1	SOX9,FGFR3
GO:0010839	negative regulation of keratinocyte proliferation	0.010863412015145226	0.010863412015145226	+1	EPPK1,FGFR2
GO:0010452	histone H3-K36 methylation	0.010863412015145226	0.010863412015145226	+1	SETD2,NSD1
GO:0021772	olfactory bulb development	0.010863412015145226	0.010863412015145226	+1	ERBB4,LRRK2
GO:0032292	peripheral nervous system axon ensheathment	0.010863412015145226	0.010863412015145226	+1	NF1,PRX
GO:0060911	cardiac cell fate commitment	0.010863412015145226	0.010863412015145226	+1	WT1,SOX17
GO:0034088	maintenance of mitotic sister chromatid cohesion	0.010863412015145226	0.010863412015145226	+1	RB1,ATRX
GO:0034086	maintenance of sister chromatid cohesion	0.010863412015145226	0.010863412015145226	+1	RB1,ATRX
GO:2000696	regulation of epithelial cell differentiation involved in kidney development	0.010863412015145226	0.010863412015145226	+1	GATA3,CTNNB1
GO:0106030	neuron projection fasciculation	0.010863412015145226	0.010863412015145226	+1	ARHGAP35,EPHA3
GO:0072350	tricarboxylic acid metabolic process	0.010863412015145226	0.010863412015145226	+1	IDH1,IDH2
GO:0007413	axonal fasciculation	0.010863412015145226	0.010863412015145226	+1	ARHGAP35,EPHA3
GO:1901532	regulation of hematopoietic progenitor cell differentiation	0.010865918238452388	0.010865918238452388	+1	GATA3,NOTCH1,RUNX1,CBFB
GO:0019217	regulation of fatty acid metabolic process	0.010865918238452388	0.010865918238452388	+1	AKT1,SOX9,BRCA1,NCOR1
GO:1905269	positive regulation of chromatin organization	0.010865918238452388	0.010865918238452388	+1	CTNNB1,BRCA1,SMAD4,SIN3A
GO:0043542	endothelial cell migration	0.010957016019087685	0.010957016019087685	+1	PIK3CA,NF1,GATA3,NOTCH1,AKT1,PIK3CG,EGR3
GO:0040013	negative regulation of locomotion	0.011002895272954774	0.011002895272954774	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1
GO:0006396	RNA processing	0.01103837812023391	0.01103837812023391	+1	TP53,EGFR,PIK3R1,WT1,PRX,U2AF1,SF3B1,PPP2R1A,CDK12,NCOR1,RPL5,SMAD2,ERCC2,PCBP1
GO:2000177	regulation of neural precursor cell proliferation	0.01123039132170867	0.01123039132170867	+1	NF1,CTNNB1,LRRK2
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	0.01123039132170867	0.01123039132170867	+1	CDKN2A,TAF1,RPL5
GO:0007422	peripheral nervous system development	0.01123039132170867	0.01123039132170867	+1	NF1,RUNX1,PRX
GO:0046324	regulation of glucose import	0.01123039132170867	0.01123039132170867	+1	PIK3R1,AKT1,PTPN11
GO:0034219	carbohydrate transmembrane transport	0.01124961235802347	0.01124961235802347	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0015749	monosaccharide transmembrane transport	0.01124961235802347	0.01124961235802347	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:1901888	regulation of cell junction assembly	0.011439400711629528	0.011439400711629528	+1	PTEN,RUNX1,EPHA3,CBFB,MIR142
GO:0034329	cell junction assembly	0.011918153687382653	0.011918153687382653	+1	PTEN,APC,CTNNB1,CDH1,RUNX1,EPHA3,CBFB,MIR142
GO:0032355	response to estradiol	0.011941138425540305	0.011941138425540305	+1	EGFR,CTNNB1,FOXA1
GO:0055008	cardiac muscle tissue morphogenesis	0.011941138425540305	0.011941138425540305	+1	NOTCH1,FGFR2,SMAD4
GO:0090199	regulation of release of cytochrome c from mitochondria	0.011941138425540305	0.011941138425540305	+1	TP53,AKT1,HGF
GO:0051179	localization	0.011967849205510292	0.011967849205510292	+1	TP53,PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,KEAP1,CDH1,ARHGAP35,CTCF,BAP1,NPM1,NRAS,IDH1,TBX3,RPL22,STK11,EPHA3,AKT1,BRAF,AR,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,U2AF1,ATRX,LRRK2,KIT,SETD2,PDGFRA,FOXA2,USP9X,BRCA2,TGFBR2,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,EGR3,RPL5,AXIN2,RAD21
GO:0046651	lymphocyte proliferation	0.012352745821696829	0.012352745821696829	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:0120161	regulation of cold-induced thermogenesis	0.01243391284290262	0.01243391284290262	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0106106	cold-induced thermogenesis	0.01243391284290262	0.01243391284290262	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0035067	negative regulation of histone acetylation	0.012445418228316097	0.012445418228316097	+1	BRCA1,SIN3A
GO:0072273	metanephric nephron morphogenesis	0.012445418228316097	0.012445418228316097	+1	SOX9,WT1
GO:0030889	negative regulation of B cell proliferation	0.012445418228316097	0.012445418228316097	+1	CDKN2A,ATM
GO:1905208	negative regulation of cardiocyte differentiation	0.012445418228316097	0.012445418228316097	+1	EGFR,SMAD4
GO:0021988	olfactory lobe development	0.012445418228316097	0.012445418228316097	+1	ERBB4,LRRK2
GO:1903209	positive regulation of oxidative stress-induced cell death	0.012445418228316097	0.012445418228316097	+1	FBXW7,TLR4
GO:1902969	mitotic DNA replication	0.012445418228316097	0.012445418228316097	+1	CHEK2,BRCA2
GO:0002320	lymphoid progenitor cell differentiation	0.012445418228316097	0.012445418228316097	+1	NOTCH1,FLT3
GO:0010224	response to UV-B	0.012445418228316097	0.012445418228316097	+1	STK11,CDKN1A
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	0.012445418228316097	0.012445418228316097	+1	NOTCH1,TGFBR2
GO:0060231	mesenchymal to epithelial transition	0.012445418228316097	0.012445418228316097	+1	GATA3,WT1
GO:0032886	regulation of microtubule-based process	0.012487360942897456	0.012487360942897456	+1	APC,NAV3,NPM1,STK11,EPHA3,BRCA1
GO:0051216	cartilage development	0.012487360942897456	0.012487360942897456	+1	RUNX1,SOX9,FGFR3,PTPN11
GO:0120034	positive regulation of plasma membrane bounded cell projection assembly	0.012487360942897456	0.012487360942897456	+1	PIK3CA,APC,PIK3R1,ARHGAP35
GO:0010863	positive regulation of phospholipase C activity	0.012521500681639347	0.012521500681639347	+1	EGFR,KIT,PDGFRA
GO:0071300	cellular response to retinoic acid	0.012521500681639347	0.012521500681639347	+1	EPHA3,SOX9,ATM
GO:0038202	TORC1 signaling	0.012521500681639347	0.012521500681639347	+1	STK11,ATM,MTOR
GO:0035019	somatic stem cell population maintenance	0.012521500681639347	0.012521500681639347	+1	SOX9,SMAD4,SMAD2
GO:0010038	response to metal ion	0.012726510332032613	0.012726510332032613	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:0032943	mononuclear cell proliferation	0.013015655682859069	0.013015655682859069	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:1904894	positive regulation of receptor signaling pathway via STAT	0.01330376216338101	0.01330376216338101	+1	NOTCH1,ERBB4,KIT
GO:0070997	neuron death	0.01330376216338101	0.01330376216338101	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
GO:0097485	neuron projection guidance	0.013586216003400608	0.013586216003400608	+1	PIK3CA,PIK3R1,NOTCH1,ARHGAP35,EPHA3,PTPN11
GO:0007411	axon guidance	0.013586216003400608	0.013586216003400608	+1	PIK3CA,PIK3R1,NOTCH1,ARHGAP35,EPHA3,PTPN11
GO:0006261	DNA-dependent DNA replication	0.01368875743412897	0.01368875743412897	+1	ATRX,POLQ,CHEK2,BRCA2,ATR
GO:0071354	cellular response to interleukin-6	0.014067807473981127	0.014067807473981127	+1	CEBPA,SMAD4,PTPN11
GO:1900274	regulation of phospholipase C activity	0.014067807473981127	0.014067807473981127	+1	EGFR,KIT,PDGFRA
GO:0060079	excitatory postsynaptic potential	0.014067807473981127	0.014067807473981127	+1	PTEN,AKT1,LRRK2
GO:0009266	response to temperature stimulus	0.014067807473981127	0.014067807473981127	+1	AKT1,ATM,MTOR,EP300,ATR
GO:0006984	ER-nucleus signaling pathway	0.014067807473981127	0.014067807473981127	+1	TP53,FBXW7,NFE2L2
GO:0007530	sex determination	0.014107074265035437	0.014107074265035437	+1	SOX9,WT1
GO:2000757	negative regulation of peptidyl-lysine acetylation	0.014107074265035437	0.014107074265035437	+1	BRCA1,SIN3A
GO:0008595	anterior/posterior axis specification, embryo	0.014107074265035437	0.014107074265035437	+1	TBX3,WT1
GO:0007351	tripartite regional subdivision	0.014107074265035437	0.014107074265035437	+1	TBX3,WT1
GO:0007350	blastoderm segmentation	0.014107074265035437	0.014107074265035437	+1	TBX3,WT1
GO:0045686	negative regulation of glial cell differentiation	0.014107074265035437	0.014107074265035437	+1	NF1,NOTCH1
GO:0035162	embryonic hemopoiesis	0.014107074265035437	0.014107074265035437	+1	KIT,TGFBR2
GO:0006103	2-oxoglutarate metabolic process	0.014107074265035437	0.014107074265035437	+1	IDH1,IDH2
GO:0048385	regulation of retinoic acid receptor signaling pathway	0.014107074265035437	0.014107074265035437	+1	ASXL1,EZH2
GO:0072425	signal transduction involved in G2 DNA damage checkpoint	0.014107074265035437	0.014107074265035437	+1	ATM,BRCA1
GO:0072207	metanephric epithelium development	0.014107074265035437	0.014107074265035437	+1	SOX9,WT1
GO:0051223	regulation of protein transport	0.014601284454201823	0.014601284454201823	+1	TP53,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,TLR4,LRRK2,FOXA2
GO:0034330	cell junction organization	0.014741806567090735	0.014741806567090735	+1	PTEN,APC,PIK3R1,CTNNB1,CDH1,RUNX1,EPHA3,LRRK2,CBFB,MIR142
GO:0045747	positive regulation of Notch signaling pathway	0.01477179778267984	0.01477179778267984	+1	NOTCH1,ELF3,EP300
GO:2000756	regulation of peptidyl-lysine acetylation	0.01477179778267984	0.01477179778267984	+1	BRCA1,SMAD4,SIN3A
GO:1990845	adaptive thermogenesis	0.015067703460732508	0.015067703460732508	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0051345	positive regulation of hydrolase activity	0.015284010595745289	0.015284010595745289	+1	EGFR,NF1,CDKN2A,AKT1,MTOR,KIT,PDGFRA,FGFR2,FGFR3,EZH2
GO:0009952	anterior/posterior pattern specification	0.015335882020896498	0.015335882020896498	+1	TBX3,WT1,FOXA2,SMAD2
GO:1901653	cellular response to peptide	0.015336261216143414	0.015336261216143414	+1	TP53,PIK3CA,APC,PIK3R1,AKT1,TLR4,PTPN11
GO:0050866	negative regulation of cell activation	0.01544087903426309	0.01544087903426309	+1	CDKN2A,RUNX1,ATM,PDGFRA,CBFB
GO:0032873	negative regulation of stress-activated MAPK cascade	0.015564482365000146	0.015564482365000146	+1	MAPK8IP1,MECOM,NCOR1
GO:0045005	DNA-dependent DNA replication maintenance of fidelity	0.015564482365000146	0.015564482365000146	+1	ATRX,BRCA2,ATR
GO:0014013	regulation of gliogenesis	0.015564482365000146	0.015564482365000146	+1	NF1,NOTCH1,MIR142
GO:0070303	negative regulation of stress-activated protein kinase signaling cascade	0.015564482365000146	0.015564482365000146	+1	MAPK8IP1,MECOM,NCOR1
GO:0021537	telencephalon development	0.015803494444984544	0.015803494444984544	+1	PTEN,NF1,ERBB4,LRRK2
GO:0008643	carbohydrate transport	0.015803494444984544	0.015803494444984544	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0071897	DNA biosynthetic process	0.015803494444984544	0.015803494444984544	+1	TP53,ATM,HGF,CDKN1A,ATR
GO:0071514	genetic imprinting	0.01591053957620971	0.01591053957620971	+1	DNMT3A,CTCF
GO:0035994	response to muscle stretch	0.01591053957620971	0.01591053957620971	+1	PIK3CA,CTNNB1
GO:0032331	negative regulation of chondrocyte differentiation	0.01591053957620971	0.01591053957620971	+1	SOX9,PTPN11
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	0.01591053957620971	0.01591053957620971	+1	TP53,BRCA1
GO:0035635	entry of bacterium into host cell	0.01591053957620971	0.01591053957620971	+1	CTNNB1,CDH1
GO:0010165	response to X-ray	0.01591053957620971	0.01591053957620971	+1	GATA3,ATM
GO:0038092	nodal signaling pathway	0.01591053957620971	0.01591053957620971	+1	ACVR1B,SMAD2
GO:0035108	limb morphogenesis	0.016276386626349646	0.016276386626349646	+1	CTNNB1,TBX3,FGFR2
GO:0048644	muscle organ morphogenesis	0.016276386626349646	0.016276386626349646	+1	NOTCH1,FGFR2,SMAD4
GO:0035107	appendage morphogenesis	0.016276386626349646	0.016276386626349646	+1	CTNNB1,TBX3,FGFR2
GO:0032206	positive regulation of telomere maintenance	0.016276386626349646	0.016276386626349646	+1	ATM,ATRX,ATR
GO:0046834	lipid phosphorylation	0.016276386626349646	0.016276386626349646	+1	PIK3CA,PIK3R1,PIK3CG
GO:0048639	positive regulation of developmental growth	0.016276386626349646	0.016276386626349646	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0060415	muscle tissue morphogenesis	0.016276386626349646	0.016276386626349646	+1	NOTCH1,FGFR2,SMAD4
GO:0090316	positive regulation of intracellular protein transport	0.016467238917381163	0.016467238917381163	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1
GO:0030258	lipid modification	0.01668578992969202	0.01668578992969202	+1	PIK3CA,PTEN,PIK3R1,AKT1,PIK3CG,SOX9
GO:0120035	regulation of plasma membrane bounded cell projection organization	0.016904119317627087	0.016904119317627087	+1	PIK3CA,PTEN,APC,PIK3R1,ARHGAP35,EPHA3,AKT1,LRRK2,EP300
GO:0051966	regulation of synaptic transmission, glutamatergic	0.01715971291343462	0.01715971291343462	+1	TSHZ3,LRRK2,MIR142
GO:0046824	positive regulation of nucleocytoplasmic transport	0.01715971291343462	0.01715971291343462	+1	TP53,PIK3R1,CDH1
GO:0045444	fat cell differentiation	0.017288893683873905	0.017288893683873905	+1	GATA3,CEBPA,AKT1,EP300,ASXL1
GO:1902115	regulation of organelle assembly	0.017288893683873905	0.017288893683873905	+1	ARHGAP35,NPM1,BRCA1,LRRK2,SMAD4
GO:0110110	positive regulation of animal organ morphogenesis	0.017725002095889675	0.017725002095889675	+1	GATA3,SOX9
GO:0071850	mitotic cell cycle arrest	0.017725002095889675	0.017725002095889675	+1	CDKN1B,CDKN1A
GO:0072111	cell proliferation involved in kidney development	0.017725002095889675	0.017725002095889675	+1	GATA3,WT1
GO:0001659	temperature homeostasis	0.017725002095889675	0.017725002095889675	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0014037	Schwann cell differentiation	0.017725002095889675	0.017725002095889675	+1	NF1,PRX
GO:2000678	negative regulation of transcription regulatory region DNA binding	0.017725002095889675	0.017725002095889675	+1	TAF1,SIN3A
GO:0003338	metanephros morphogenesis	0.017725002095889675	0.017725002095889675	+1	SOX9,WT1
GO:0051570	regulation of histone H3-K9 methylation	0.017725002095889675	0.017725002095889675	+1	ATRX,BRCA1
GO:1904262	negative regulation of TORC1 signaling	0.017725002095889675	0.017725002095889675	+1	STK11,ATM
GO:0042772	DNA damage response, signal transduction resulting in transcription	0.017725002095889675	0.017725002095889675	+1	TP53,BRCA1
GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	0.017725002095889675	0.017725002095889675	+1	RUNX1,CBFB
GO:0051444	negative regulation of ubiquitin-protein transferase activity	0.017725002095889675	0.017725002095889675	+1	CDKN2A,RPL5
GO:0055003	cardiac myofibril assembly	0.017725002095889675	0.017725002095889675	+1	PDGFRA,SMAD4
GO:0045446	endothelial cell differentiation	0.017765441693611782	0.017765441693611782	+1	NOTCH1,SMAD4,SOX17,VEZF1
GO:0046635	positive regulation of alpha-beta T cell activation	0.017875565318949793	0.017875565318949793	+1	RUNX1,TGFBR2,CBFB
GO:0043030	regulation of macrophage activation	0.017875565318949793	0.017875565318949793	+1	CEBPA,TLR4,MIR142
GO:0046637	regulation of alpha-beta T cell differentiation	0.017875565318949793	0.017875565318949793	+1	RUNX1,TGFBR2,CBFB
GO:0031669	cellular response to nutrient levels	0.01797106773987259	0.01797106773987259	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A
GO:0010498	proteasomal protein catabolic process	0.018052394765609384	0.018052394765609384	+1	FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,TBL1XR1,SPOP
GO:0003002	regionalization	0.0183876290320416	0.0183876290320416	+1	TBX3,WT1,FGFR2,FOXA2,SMAD2
GO:0097435	supramolecular fiber organization	0.0183876290320416	0.0183876290320416	+1	PIK3CA,APC,NAV3,NF1,PIK3R1,CDKN2A,RB1,ARHGAP35,EPPK1,PDGFRA,SMAD4
GO:0006109	regulation of carbohydrate metabolic process	0.0183876290320416	0.0183876290320416	+1	TP53,AKT1,EP300,FOXA2,NCOR1
GO:0001819	positive regulation of cytokine production	0.01843285269031732	0.01843285269031732	+1	GATA3,CTNNB1,RUNX1,TLR4,BRCA1,SETD2,EP300,PTPN11
GO:0003006	developmental process involved in reproduction	0.018484523531609977	0.018484523531609977	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
GO:0099565	chemical synaptic transmission, postsynaptic	0.01874390900625891	0.01874390900625891	+1	PTEN,AKT1,LRRK2
GO:1901880	negative regulation of protein depolymerization	0.01874390900625891	0.01874390900625891	+1	PIK3CA,APC,NAV3
GO:0045861	negative regulation of proteolysis	0.018871148471412313	0.018871148471412313	+1	CDKN2A,AKT1,HGF,LRRK2,TAF1,RPL5
GO:0070201	regulation of establishment of protein localization	0.01893839524959707	0.01893839524959707	+1	TP53,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,TLR4,LRRK2,FOXA2
GO:0006473	protein acetylation	0.019253704399550965	0.019253704399550965	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0001952	regulation of cell-matrix adhesion	0.01941108496030997	0.01941108496030997	+1	PTEN,NF1,CDKN2A,EPHA3
GO:0034605	cellular response to heat	0.01941108496030997	0.01941108496030997	+1	ATM,MTOR,EP300,ATR
GO:0008543	fibroblast growth factor receptor signaling pathway	0.01941108496030997	0.01941108496030997	+1	GATA3,FGFR2,FGFR3,PTPN11
GO:0042177	negative regulation of protein catabolic process	0.01941108496030997	0.01941108496030997	+1	EGFR,CDKN2A,TAF1,RPL5
GO:0090087	regulation of peptide transport	0.01941108496030997	0.01941108496030997	+1	TP53,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,TLR4,LRRK2,FOXA2
GO:0098751	bone cell development	0.019546268887048975	0.019546268887048975	+1	FBXW7,KIT
GO:0007221	positive regulation of transcription of Notch receptor target	0.019546268887048975	0.019546268887048975	+1	NOTCH1,EP300
GO:0007252	I-kappaB phosphorylation	0.019546268887048975	0.019546268887048975	+1	AKT1,TLR4
GO:0035313	wound healing, spreading of epidermal cells	0.019546268887048975	0.019546268887048975	+1	PTEN,MTOR
GO:0072012	glomerulus vasculature development	0.019546268887048975	0.019546268887048975	+1	WT1,PDGFRA
GO:0061037	negative regulation of cartilage development	0.019546268887048975	0.019546268887048975	+1	SOX9,PTPN11
GO:2000811	negative regulation of anoikis	0.019546268887048975	0.019546268887048975	+1	PIK3CA,NOTCH1
GO:0001836	release of cytochrome c from mitochondria	0.019546268887048975	0.019546268887048975	+1	TP53,AKT1,HGF
GO:0030071	regulation of mitotic metaphase/anaphase transition	0.019546268887048975	0.019546268887048975	+1	APC,RB1,ATM
GO:0006886	intracellular protein transport	0.019628080529231002	0.019628080529231002	+1	TP53,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,NPM1,IDH1,RPL22,AKT1,U2AF1,LRRK2,SETD2,USP9X,RPL5
GO:0031349	positive regulation of defense response	0.019646223192512358	0.019646223192512358	+1	KRAS,NRAS,CEBPA,TLR4,EP300,SIN3A,MIR142
GO:0030336	negative regulation of cell migration	0.019965378455741017	0.019965378455741017	+1	PTEN,NAV3,NF1,NOTCH1,CDH1,AKT1,EPPK1
GO:0030177	positive regulation of Wnt signaling pathway	0.019965378455741017	0.019965378455741017	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
GO:0031344	regulation of cell projection organization	0.019965378455741017	0.019965378455741017	+1	PIK3CA,PTEN,APC,PIK3R1,ARHGAP35,EPHA3,AKT1,LRRK2,EP300
GO:0010810	regulation of cell-substrate adhesion	0.020042499033464067	0.020042499033464067	+1	PTEN,NF1,CDKN2A,NOTCH1,EPHA3
GO:0010634	positive regulation of epithelial cell migration	0.020042499033464067	0.020042499033464067	+1	GATA3,AKT1,PIK3CG,SOX9,MTOR
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	0.020042499033464067	0.020042499033464067	+1	APC,RB1,ATM
GO:0007051	spindle organization	0.020042499033464067	0.020042499033464067	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:0006740	NADPH regeneration	0.020042499033464067	0.020042499033464067	+1	TP53,IDH1
GO:0006306	DNA methylation	0.020042499033464067	0.020042499033464067	+1	DNMT3A,WT1,ATRX
GO:0006289	nucleotide-excision repair	0.020042499033464067	0.020042499033464067	+1	TP53,EP300,BRCA2,ERCC2
GO:0006305	DNA alkylation	0.020042499033464067	0.020042499033464067	+1	DNMT3A,WT1,ATRX
GO:0031398	positive regulation of protein ubiquitination	0.020042499033464067	0.020042499033464067	+1	PTEN,FBXW7,BRCA1,LRRK2
GO:0033260	nuclear DNA replication	0.020042499033464067	0.020042499033464067	+1	ATRX,CHEK2,BRCA2
GO:0032956	regulation of actin cytoskeleton organization	0.020042499033464067	0.020042499033464067	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,MTOR,PDGFRA,SMAD4
GO:2000243	positive regulation of reproductive process	0.020042499033464067	0.020042499033464067	+1	SOX9,WT1,ACVR1B
GO:1901984	negative regulation of protein acetylation	0.020042499033464067	0.020042499033464067	+1	BRCA1,SIN3A
GO:0061437	renal system vasculature development	0.020042499033464067	0.020042499033464067	+1	WT1,PDGFRA
GO:0061440	kidney vasculature development	0.020042499033464067	0.020042499033464067	+1	WT1,PDGFRA
GO:1901224	positive regulation of NIK/NF-kappaB signaling	0.020042499033464067	0.020042499033464067	+1	EGFR,TLR4,EP300
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	0.020042499033464067	0.020042499033464067	+1	APC,RB1,ATM
GO:0045687	positive regulation of glial cell differentiation	0.020042499033464067	0.020042499033464067	+1	NOTCH1,MIR142
GO:0048710	regulation of astrocyte differentiation	0.020042499033464067	0.020042499033464067	+1	NOTCH1,MIR142
GO:0046323	glucose import	0.020042499033464067	0.020042499033464067	+1	PIK3R1,AKT1,PTPN11
GO:0090201	negative regulation of release of cytochrome c from mitochondria	0.020042499033464067	0.020042499033464067	+1	AKT1,HGF
GO:0048854	brain morphogenesis	0.020042499033464067	0.020042499033464067	+1	PTEN,NF1
GO:0046631	alpha-beta T cell activation	0.02015207450470182	0.02015207450470182	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:0032869	cellular response to insulin stimulus	0.020216754194375533	0.020216754194375533	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0007254	JNK cascade	0.020216754194375533	0.020216754194375533	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:1903708	positive regulation of hemopoiesis	0.020700834955432387	0.020700834955432387	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0016331	morphogenesis of embryonic epithelium	0.020700834955432387	0.020700834955432387	+1	GATA3,SOX9,FGFR2
GO:0051053	negative regulation of DNA metabolic process	0.020700834955432387	0.020700834955432387	+1	TP53,ATM,POLQ,CDKN1A
GO:0051145	smooth muscle cell differentiation	0.020700834955432387	0.020700834955432387	+1	NOTCH1,KIT,FGFR2
GO:0048839	inner ear development	0.020700834955432387	0.020700834955432387	+1	SOX9,FGFR2,PTPN11
GO:1902107	positive regulation of leukocyte differentiation	0.020700834955432387	0.020700834955432387	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0097306	cellular response to alcohol	0.021585233224290828	0.021585233224290828	+1	CTNNB1,CDH1,BRCA1
GO:0044784	metaphase/anaphase transition of cell cycle	0.021585233224290828	0.021585233224290828	+1	APC,RB1,ATM
GO:0072175	epithelial tube formation	0.021585233224290828	0.021585233224290828	+1	GATA3,SOX9,FGFR2
GO:0048662	negative regulation of smooth muscle cell proliferation	0.021585233224290828	0.021585233224290828	+1	PTEN,CDKN1B,CDKN1A
GO:0090090	negative regulation of canonical Wnt signaling pathway	0.021585233224290828	0.021585233224290828	+1	APC,STK11,SOX9,SOX17,AXIN2
GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	0.021585233224290828	0.021585233224290828	+1	RUNX1,TGFBR2,CBFB
GO:0010965	regulation of mitotic sister chromatid separation	0.021585233224290828	0.021585233224290828	+1	APC,RB1,ATM
GO:0045815	positive regulation of gene expression, epigenetic	0.021585233224290828	0.021585233224290828	+1	ARID1A,EP300,SF3B1
GO:1903749	positive regulation of establishment of protein localization to mitochondrion	0.021585233224290828	0.021585233224290828	+1	TP53,FBXW7,BAP1
GO:1903051	negative regulation of proteolysis involved in cellular protein catabolic process	0.021585233224290828	0.021585233224290828	+1	CDKN2A,TAF1,RPL5
GO:1903203	regulation of oxidative stress-induced neuron death	0.021851246871090642	0.021851246871090642	+1	FBXW7,TLR4
GO:0071425	hematopoietic stem cell proliferation	0.021851246871090642	0.021851246871090642	+1	RUNX1,MECOM
GO:0048713	regulation of oligodendrocyte differentiation	0.021851246871090642	0.021851246871090642	+1	NF1,NOTCH1
GO:0006611	protein export from nucleus	0.021851246871090642	0.021851246871090642	+1	TP53,CDKN2A,NPM1,U2AF1,SETD2
GO:0001569	branching involved in blood vessel morphogenesis	0.021851246871090642	0.021851246871090642	+1	CTNNB1,TGFBR2
GO:0051250	negative regulation of lymphocyte activation	0.021851246871090642	0.021851246871090642	+1	CDKN2A,RUNX1,ATM,CBFB
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.021851246871090642	0.021851246871090642	+1	NFE2L2,AKT1
GO:0030277	maintenance of gastrointestinal epithelium	0.021851246871090642	0.021851246871090642	+1	SOX9,TLR4
GO:0060350	endochondral bone morphogenesis	0.021851246871090642	0.021851246871090642	+1	SOX9,FGFR3
GO:0043433	negative regulation of DNA-binding transcription factor activity	0.021851246871090642	0.021851246871090642	+1	CDKN2A,RB1,KEAP1,FOXA2,TAF1
GO:0045116	protein neddylation	0.021851246871090642	0.021851246871090642	+1	CDKN2A,RPL5
GO:1903038	negative regulation of leukocyte cell-cell adhesion	0.022425732974480174	0.022425732974480174	+1	CDKN2A,RUNX1,AKT1,CBFB
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	0.022433586858009676	0.022433586858009676	+1	TP53,STK11,EP300
GO:0055006	cardiac cell development	0.022433586858009676	0.022433586858009676	+1	NOTCH1,PDGFRA,SMAD4
GO:0060759	regulation of response to cytokine stimulus	0.022841268853937283	0.022841268853937283	+1	RUNX1,TLR4,CBFB,PTPN11,LIFR
GO:0072659	protein localization to plasma membrane	0.02288610800893817	0.02288610800893817	+1	EGFR,PIK3R1,CDH1,EPHA3,AKT1,AR
GO:1902903	regulation of supramolecular fiber organization	0.02295727424133905	0.02295727424133905	+1	PIK3CA,APC,NAV3,PIK3R1,RB1,ARHGAP35,SMAD4
GO:0006661	phosphatidylinositol biosynthetic process	0.023038200655543958	0.023038200655543958	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
GO:0043967	histone H4 acetylation	0.023389022251653166	0.023389022251653166	+1	BRCA1,EP300,BRCA2
GO:0051306	mitotic sister chromatid separation	0.023389022251653166	0.023389022251653166	+1	APC,RB1,ATM
GO:0044786	cell cycle DNA replication	0.023389022251653166	0.023389022251653166	+1	ATRX,CHEK2,BRCA2
GO:0150116	regulation of cell-substrate junction organization	0.023389022251653166	0.023389022251653166	+1	PTEN,PIK3R1,EPHA3
GO:0032102	negative regulation of response to external stimulus	0.02361088931122167	0.02361088931122167	+1	PTEN,GATA3,RB1,NOTCH1,EPPK1,PDGFRA,MIR142
GO:0060964	regulation of gene silencing by miRNA	0.02362858690630913	0.02362858690630913	+1	TP53,EGFR,AJUBA,NCOR1
GO:0006334	nucleosome assembly	0.02362858690630913	0.02362858690630913	+1	NPM1,SOX9,ATRX,HIST1H2BD
GO:0051222	positive regulation of protein transport	0.02362858690630913	0.02362858690630913	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,TLR4
GO:0001709	cell fate determination	0.02379520984617571	0.02379520984617571	+1	GATA3,SOX17
GO:0046639	negative regulation of alpha-beta T cell differentiation	0.02379520984617571	0.02379520984617571	+1	RUNX1,CBFB
GO:0030851	granulocyte differentiation	0.02379520984617571	0.02379520984617571	+1	RUNX1,CEBPA
GO:0021879	forebrain neuron differentiation	0.02379520984617571	0.02379520984617571	+1	ERBB4,FGFR2
GO:0045671	negative regulation of osteoclast differentiation	0.02379520984617571	0.02379520984617571	+1	FBXW7,TLR4
GO:0048566	embryonic digestive tract development	0.02379520984617571	0.02379520984617571	+1	PDGFRA,FGFR2
GO:0072657	protein localization to membrane	0.02379520984617571	0.02379520984617571	+1	TP53,EGFR,PIK3R1,CDH1,RPL22,EPHA3,AKT1,BRAF,AR,RPL5
GO:1903055	positive regulation of extracellular matrix organization	0.02379520984617571	0.02379520984617571	+1	RB1,RUNX1
GO:0060966	regulation of gene silencing by RNA	0.024195014721906407	0.024195014721906407	+1	TP53,EGFR,AJUBA,NCOR1
GO:0060147	regulation of posttranscriptional gene silencing	0.024195014721906407	0.024195014721906407	+1	TP53,EGFR,AJUBA,NCOR1
GO:0030032	lamellipodium assembly	0.02421958435316864	0.02421958435316864	+1	PIK3CA,PIK3R1,KIT
GO:0070373	negative regulation of ERK1 and ERK2 cascade	0.02421958435316864	0.02421958435316864	+1	PTEN,TLR4,SMAD4
GO:0010812	negative regulation of cell-substrate adhesion	0.02421958435316864	0.02421958435316864	+1	PTEN,CDKN2A,NOTCH1
GO:0031346	positive regulation of cell projection organization	0.0242789844287274	0.0242789844287274	+1	PIK3CA,APC,PIK3R1,ARHGAP35,EPHA3,EP300
GO:0031347	regulation of defense response	0.024460471394480127	0.024460471394480127	+1	KRAS,GATA3,RB1,NRAS,CEBPA,TLR4,EP300,SIN3A,PTPN11,MIR142
GO:0051049	regulation of transport	0.024643628735682103	0.024643628735682103	+1	TP53,PTEN,PIK3R1,CDKN2A,NOTCH1,FBXW7,CTNNB1,CDH1,BAP1,STK11,EPHA3,AKT1,BRAF,TLR4,LRRK2,SETD2,FOXA2,PTPN11
GO:0008380	RNA splicing	0.0246856071146386	0.0246856071146386	+1	PIK3R1,WT1,PRX,U2AF1,SF3B1,PPP2R1A,CDK12,PCBP1
GO:0007052	mitotic spindle organization	0.02478456278638317	0.02478456278638317	+1	STAG2,CHEK2,SMC1A,SMC3
GO:0046328	regulation of JNK cascade	0.02478456278638317	0.02478456278638317	+1	EGFR,MAPK8IP1,MECOM,NCOR1
GO:0007517	muscle organ development	0.02509394135942584	0.02509394135942584	+1	NOTCH1,WT1,FGFR2,SMAD4,EGR3
GO:2000573	positive regulation of DNA biosynthetic process	0.02520911246876787	0.02520911246876787	+1	ATM,HGF,ATR
GO:0009991	response to extracellular stimulus	0.025523346861593885	0.025523346861593885	+1	TP53,ARHGAP35,MTOR,LRRK2,FOXA2,CDKN1A
GO:0016071	mRNA metabolic process	0.025655519811972907	0.025655519811972907	+1	TP53,NPM1,RPL22,AKT1,ATM,U2AF1,SF3B1,PPP2R1A,RPL5,AXIN2,ERCC2,PCBP1
GO:0007005	mitochondrion organization	0.025720978033123967	0.025720978033123967	+1	TP53,CDKN2A,FBXW7,BAP1,AKT1,HGF,ERBB4,LRRK2,EP300
GO:1904886	beta-catenin destruction complex disassembly	0.02573584157111175	0.02573584157111175	+1	APC,CTNNB1
GO:0035315	hair cell differentiation	0.02573584157111175	0.02573584157111175	+1	CTNNB1,ERCC2
GO:0021955	central nervous system neuron axonogenesis	0.02573584157111175	0.02573584157111175	+1	PTEN,ARHGAP35
GO:0032727	positive regulation of interferon-alpha production	0.02573584157111175	0.02573584157111175	+1	TLR4,SETD2
GO:0046599	regulation of centriole replication	0.02573584157111175	0.02573584157111175	+1	NPM1,BRCA1
GO:0000209	protein polyubiquitination	0.02573584157111175	0.02573584157111175	+1	CDKN2A,FBXW7,CTNNB1,BRCA1,TAF1,CBFB,SPOP
GO:0032069	regulation of nuclease activity	0.02573584157111175	0.02573584157111175	+1	NPM1,AKT1
GO:0033233	regulation of protein sumoylation	0.02573584157111175	0.02573584157111175	+1	CDKN2A,CTNNB1
GO:0003272	endocardial cushion formation	0.02573584157111175	0.02573584157111175	+1	NOTCH1,TGFBR2
GO:0036475	neuron death in response to oxidative stress	0.02573584157111175	0.02573584157111175	+1	FBXW7,TLR4
GO:0006413	translational initiation	0.025969283321870925	0.025969283321870925	+1	NPM1,RPL22,MTOR,EIF4A2,RPL5
GO:0032868	response to insulin	0.025969283321870925	0.025969283321870925	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0060078	regulation of postsynaptic membrane potential	0.026048048390331896	0.026048048390331896	+1	PTEN,AKT1,LRRK2
GO:0060541	respiratory system development	0.026048048390331896	0.026048048390331896	+1	CEBPA,WT1,FGFR2
GO:1901983	regulation of protein acetylation	0.026048048390331896	0.026048048390331896	+1	BRCA1,SMAD4,SIN3A
GO:0010721	negative regulation of cell development	0.026700855629963428	0.026700855629963428	+1	PTEN,NF1,NOTCH1,FBXW7
GO:0006360	transcription by RNA polymerase I	0.02714031527626039	0.02714031527626039	+1	MTOR,TAF1,ERCC2
GO:1905818	regulation of chromosome separation	0.02714031527626039	0.02714031527626039	+1	APC,RB1,ATM
GO:0070988	demethylation	0.02714031527626039	0.02714031527626039	+1	KDM5C,TET2,USP9X
GO:0007369	gastrulation	0.027409889392583767	0.027409889392583767	+1	SETD2,FOXA2,SOX17,SMAD2
GO:0014014	negative regulation of gliogenesis	0.027906460195674544	0.027906460195674544	+1	NF1,NOTCH1
GO:0070723	response to cholesterol	0.027906460195674544	0.027906460195674544	+1	TGFBR2,SMAD2
GO:0048147	negative regulation of fibroblast proliferation	0.027906460195674544	0.027906460195674544	+1	TP53,NF1
GO:2000209	regulation of anoikis	0.027906460195674544	0.027906460195674544	+1	PIK3CA,NOTCH1
GO:0007095	mitotic G2 DNA damage checkpoint	0.027906460195674544	0.027906460195674544	+1	ATM,CDKN1A
GO:0060389	pathway-restricted SMAD protein phosphorylation	0.028147657939143148	0.028147657939143148	+1	SMAD4,TGFBR2,ACVR2A
GO:0033045	regulation of sister chromatid segregation	0.028147657939143148	0.028147657939143148	+1	APC,RB1,ATM
GO:0043242	negative regulation of protein-containing complex disassembly	0.028147657939143148	0.028147657939143148	+1	PIK3CA,APC,NAV3
GO:0030316	osteoclast differentiation	0.028147657939143148	0.028147657939143148	+1	FBXW7,MTOR,TLR4
GO:1901652	response to peptide	0.028266086040576472	0.028266086040576472	+1	TP53,PIK3CA,APC,PIK3R1,AKT1,TLR4,PTPN11
GO:2001236	regulation of extrinsic apoptotic signaling pathway	0.028805124974640745	0.028805124974640745	+1	PTEN,AKT1,AR,BRCA1
GO:0061045	negative regulation of wound healing	0.029283698582289207	0.029283698582289207	+1	PTEN,EPPK1,PDGFRA
GO:0070301	cellular response to hydrogen peroxide	0.029283698582289207	0.029283698582289207	+1	NFE2L2,HGF,LRRK2
GO:0001817	regulation of cytokine production	0.02930719888270686	0.02930719888270686	+1	NAV3,GATA3,CTNNB1,RUNX1,TLR4,BRCA1,SETD2,EP300,SMAD4,PTPN11,MIR142
GO:0050776	regulation of immune response	0.02971445766857511	0.02971445766857511	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,MAP2K4,KIT,EP300,CBFB,SIN3A,PTPN11
GO:0005975	carbohydrate metabolic process	0.029744973598770423	0.029744973598770423	+1	TP53,PTEN,AKT1,BRAF,IDH2,EP300,FOXA2,NCOR1
GO:0051168	nuclear export	0.029744973598770423	0.029744973598770423	+1	TP53,CDKN2A,NPM1,U2AF1,SETD2
GO:0032970	regulation of actin filament-based process	0.029854809201980175	0.029854809201980175	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,MTOR,PDGFRA,SMAD4
GO:0070168	negative regulation of biomineral tissue development	0.02994109576574093	0.02994109576574093	+1	NOTCH1,SOX9
GO:0060317	cardiac epithelial to mesenchymal transition	0.02994109576574093	0.02994109576574093	+1	NOTCH1,TGFBR2
GO:0051567	histone H3-K9 methylation	0.02994109576574093	0.02994109576574093	+1	ATRX,BRCA1
GO:0007026	negative regulation of microtubule depolymerization	0.02994109576574093	0.02994109576574093	+1	APC,NAV3
GO:0035066	positive regulation of histone acetylation	0.02994109576574093	0.02994109576574093	+1	BRCA1,SMAD4
GO:0016578	histone deubiquitination	0.02994109576574093	0.02994109576574093	+1	BAP1,ASXL1
GO:0110150	negative regulation of biomineralization	0.02994109576574093	0.02994109576574093	+1	NOTCH1,SOX9
GO:0014741	negative regulation of muscle hypertrophy	0.02994109576574093	0.02994109576574093	+1	NOTCH1,SMAD4
GO:0010669	epithelial structure maintenance	0.02994109576574093	0.02994109576574093	+1	SOX9,TLR4
GO:0071459	protein localization to chromosome, centromeric region	0.02994109576574093	0.02994109576574093	+1	RB1,CTCF
GO:1902751	positive regulation of cell cycle G2/M phase transition	0.02994109576574093	0.02994109576574093	+1	NPM1,CCND1
GO:0010614	negative regulation of cardiac muscle hypertrophy	0.02994109576574093	0.02994109576574093	+1	NOTCH1,SMAD4
GO:1904951	positive regulation of establishment of protein localization	0.02998907725044463	0.02998907725044463	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,TLR4
GO:0007098	centrosome cycle	0.030047736428671926	0.030047736428671926	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:0035249	synaptic transmission, glutamatergic	0.030116380549465156	0.030116380549465156	+1	TSHZ3,LRRK2,MIR142
GO:1901879	regulation of protein depolymerization	0.030116380549465156	0.030116380549465156	+1	PIK3CA,APC,NAV3
GO:0010389	regulation of G2/M transition of mitotic cell cycle	0.030661684888844683	0.030661684888844683	+1	CDKN2A,ATM,CCND1,CDKN1A,PPP2R1A
GO:0010608	posttranscriptional regulation of gene expression	0.030661684888844683	0.030661684888844683	+1	TP53,EGFR,NPM1,AKT1,AJUBA,MTOR,EIF4A2,NCOR1,RPL5,SMAD2,AXIN2,MIR142
GO:0043270	positive regulation of ion transport	0.031090564950250477	0.031090564950250477	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,AKT1,BRAF,TLR4,PTPN11
GO:1905332	positive regulation of morphogenesis of an epithelium	0.0322263601623094	0.0322263601623094	+1	GATA3,SOX9
GO:0000729	DNA double-strand break processing	0.0322263601623094	0.0322263601623094	+1	ATM,BRCA1
GO:0010592	positive regulation of lamellipodium assembly	0.0322263601623094	0.0322263601623094	+1	PIK3CA,PIK3R1
GO:0021872	forebrain generation of neurons	0.0322263601623094	0.0322263601623094	+1	ERBB4,FGFR2
GO:0048384	retinoic acid receptor signaling pathway	0.0322263601623094	0.0322263601623094	+1	ASXL1,EZH2
GO:0051154	negative regulation of striated muscle cell differentiation	0.0322263601623094	0.0322263601623094	+1	NOTCH1,SMAD4
GO:0050869	negative regulation of B cell activation	0.0322263601623094	0.0322263601623094	+1	CDKN2A,ATM
GO:0042493	response to drug	0.032309914852672955	0.032309914852672955	+1	TP53,CTNNB1,CCND1,TGFBR2
GO:0000187	activation of MAPK activity	0.032309914852672955	0.032309914852672955	+1	MAP2K4,TLR4,LRRK2,KIT
GO:1903363	negative regulation of cellular protein catabolic process	0.03238137517379423	0.03238137517379423	+1	CDKN2A,TAF1,RPL5
GO:0043269	regulation of ion transport	0.033645238287475815	0.033645238287475815	+1	TP53,PIK3R1,CDKN2A,FBXW7,CTNNB1,CDH1,BAP1,AKT1,BRAF,TLR4,LRRK2,SETD2,FOXA2,PTPN11
GO:0051298	centrosome duplication	0.033645238287475815	0.033645238287475815	+1	NPM1,BRCA1,BRCA2
GO:0034612	response to tumor necrosis factor	0.033929823697054856	0.033929823697054856	+1	TP53,GATA3,NFE2L2,AKT1,BRCA1,MIR142
GO:0009267	cellular response to starvation	0.033961345687099145	0.033961345687099145	+1	TP53,MTOR,LRRK2,CDKN1A
GO:0034405	response to fluid shear stress	0.03442129491775103	0.03442129491775103	+1	NFE2L2,AKT1
GO:0002183	cytoplasmic translational initiation	0.03442129491775103	0.03442129491775103	+1	MTOR,EIF4A2
GO:0060765	regulation of androgen receptor signaling pathway	0.03442129491775103	0.03442129491775103	+1	EP300,NCOR1
GO:0060326	cell chemotaxis	0.03442129491775103	0.03442129491775103	+1	NOTCH1,PIK3CG,HGF,KIT,PDGFRA,EGR3
GO:0043407	negative regulation of MAP kinase activity	0.03442129491775103	0.03442129491775103	+1	NF1,PPP2R1A,MAPK8IP1
GO:1903533	regulation of protein targeting	0.03442129491775103	0.03442129491775103	+1	FBXW7,BAP1,LRRK2
GO:0046320	regulation of fatty acid oxidation	0.03442129491775103	0.03442129491775103	+1	AKT1,SOX9
GO:0071887	leukocyte apoptotic process	0.03442129491775103	0.03442129491775103	+1	TP53,CDKN2A,AKT1
GO:2000108	positive regulation of leukocyte apoptotic process	0.03442129491775103	0.03442129491775103	+1	TP53,CDKN2A
GO:0030901	midbrain development	0.03442129491775103	0.03442129491775103	+1	CTNNB1,FGFR2,TAF1
GO:0031058	positive regulation of histone modification	0.03442129491775103	0.03442129491775103	+1	CTNNB1,BRCA1,SMAD4
GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	0.03442129491775103	0.03442129491775103	+1	VHL,PPP2R1A
GO:0030178	negative regulation of Wnt signaling pathway	0.03450337966629494	0.03450337966629494	+1	APC,STK11,SOX9,SOX17,AXIN2
GO:2000027	regulation of animal organ morphogenesis	0.03472595904849663	0.03472595904849663	+1	GATA3,SOX9,WT1,HGF
GO:0060249	anatomical structure homeostasis	0.03479189042716407	0.03479189042716407	+1	NF1,NOTCH1,SOX9,ATM,TLR4,ATRX,ATR
GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	0.03525140617821995	0.03525140617821995	+1	RUNX1,CBFB
GO:0045740	positive regulation of DNA replication	0.03525140617821995	0.03525140617821995	+1	EGFR,ATRX
GO:0080111	DNA demethylation	0.03525140617821995	0.03525140617821995	+1	TET2,USP9X
GO:0050855	regulation of B cell receptor signaling pathway	0.03525140617821995	0.03525140617821995	+1	RUNX1,CBFB
GO:0032647	regulation of interferon-alpha production	0.03525140617821995	0.03525140617821995	+1	TLR4,SETD2
GO:0032607	interferon-alpha production	0.03525140617821995	0.03525140617821995	+1	TLR4,SETD2
GO:0030279	negative regulation of ossification	0.03525140617821995	0.03525140617821995	+1	NOTCH1,SOX9
GO:1990874	vascular associated smooth muscle cell proliferation	0.03534022897897768	0.03534022897897768	+1	PTEN,CDKN1B,CDKN1A
GO:0060173	limb development	0.03534022897897768	0.03534022897897768	+1	CTNNB1,TBX3,FGFR2
GO:0030510	regulation of BMP signaling pathway	0.03534022897897768	0.03534022897897768	+1	NOTCH1,SMAD4,SMAD2
GO:0051865	protein autoubiquitination	0.03534022897897768	0.03534022897897768	+1	BRCA1,LRRK2,TAF1
GO:0048736	appendage development	0.03534022897897768	0.03534022897897768	+1	CTNNB1,TBX3,FGFR2
GO:1904705	regulation of vascular associated smooth muscle cell proliferation	0.03534022897897768	0.03534022897897768	+1	PTEN,CDKN1B,CDKN1A
GO:0046632	alpha-beta T cell differentiation	0.03658122409210644	0.03658122409210644	+1	RUNX1,TGFBR2,CBFB
GO:1902036	regulation of hematopoietic stem cell differentiation	0.03658122409210644	0.03658122409210644	+1	GATA3,RUNX1,CBFB
GO:0002253	activation of immune response	0.03658122409210644	0.03658122409210644	+1	PIK3CA,KRAS,PIK3R1,GATA3,RUNX1,NRAS,EP300,CBFB,SIN3A
GO:0045639	positive regulation of myeloid cell differentiation	0.03658122409210644	0.03658122409210644	+1	RUNX1,ACVR1B,ACVR2A
GO:0043543	protein acylation	0.03685877827400494	0.03685877827400494	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0061311	cell surface receptor signaling pathway involved in heart development	0.037520466409561956	0.037520466409561956	+1	NOTCH1,CTNNB1
GO:0031114	regulation of microtubule depolymerization	0.037520466409561956	0.037520466409561956	+1	APC,NAV3
GO:0046825	regulation of protein export from nucleus	0.037520466409561956	0.037520466409561956	+1	TP53,CDKN2A
GO:0071276	cellular response to cadmium ion	0.037520466409561956	0.037520466409561956	+1	EGFR,AKT1
GO:0036314	response to sterol	0.037520466409561956	0.037520466409561956	+1	TGFBR2,SMAD2
GO:0045648	positive regulation of erythrocyte differentiation	0.037520466409561956	0.037520466409561956	+1	ACVR1B,ACVR2A
GO:0030218	erythrocyte differentiation	0.03769004757927217	0.03769004757927217	+1	KIT,ACVR1B,ACVR2A
GO:0006446	regulation of translational initiation	0.03769004757927217	0.03769004757927217	+1	NPM1,MTOR,EIF4A2
GO:1990778	protein localization to cell periphery	0.03769004757927217	0.03769004757927217	+1	EGFR,PIK3R1,CDH1,EPHA3,AKT1,AR
GO:0097581	lamellipodium organization	0.03769004757927217	0.03769004757927217	+1	PIK3CA,PIK3R1,KIT
GO:0002695	negative regulation of leukocyte activation	0.03771550224968358	0.03771550224968358	+1	CDKN2A,RUNX1,ATM,CBFB
GO:0006402	mRNA catabolic process	0.03814447387621967	0.03814447387621967	+1	NPM1,RPL22,AKT1,ATM,PPP2R1A,RPL5,AXIN2
GO:0031023	microtubule organizing center organization	0.03860521017748232	0.03860521017748232	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:0046700	heterocycle catabolic process	0.038640227601981464	0.038640227601981464	+1	CDKN2A,NPM1,RPL22,AKT1,ATM,TET2,PPP2R1A,RPL5,AXIN2
GO:0070167	regulation of biomineral tissue development	0.03890222046718189	0.03890222046718189	+1	NOTCH1,SOX9,ACVR2A
GO:0110149	regulation of biomineralization	0.03890222046718189	0.03890222046718189	+1	NOTCH1,SOX9,ACVR2A
GO:1903035	negative regulation of response to wounding	0.03890222046718189	0.03890222046718189	+1	PTEN,EPPK1,PDGFRA
GO:0014002	astrocyte development	0.03984882944234848	0.03984882944234848	+1	NF1,MIR142
GO:0070231	T cell apoptotic process	0.03984882944234848	0.03984882944234848	+1	TP53,AKT1
GO:0046640	regulation of alpha-beta T cell proliferation	0.03984882944234848	0.03984882944234848	+1	TGFBR2,MAPK8IP1
GO:0032330	regulation of chondrocyte differentiation	0.03984882944234848	0.03984882944234848	+1	SOX9,PTPN11
GO:2000758	positive regulation of peptidyl-lysine acetylation	0.03984882944234848	0.03984882944234848	+1	BRCA1,SMAD4
GO:0002757	immune response-activating signal transduction	0.039943022525855264	0.039943022525855264	+1	PIK3CA,KRAS,PIK3R1,GATA3,RUNX1,NRAS,EP300,CBFB
GO:0002429	immune response-activating cell surface receptor signaling pathway	0.039943022525855264	0.039943022525855264	+1	PIK3CA,KRAS,PIK3R1,GATA3,RUNX1,NRAS,EP300,CBFB
GO:1905897	regulation of response to endoplasmic reticulum stress	0.04008584572945031	0.04008584572945031	+1	PIK3R1,NFE2L2,LRRK2
GO:0042552	myelination	0.04008584572945031	0.04008584572945031	+1	PTEN,NF1,PRX
GO:0042593	glucose homeostasis	0.04016572337614004	0.04016572337614004	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:0048588	developmental cell growth	0.04016572337614004	0.04016572337614004	+1	CTNNB1,SOX9,USP9X,SIN3A
GO:0031589	cell-substrate adhesion	0.04027460388855474	0.04027460388855474	+1	PTEN,NF1,PIK3R1,CDKN2A,NOTCH1,EPHA3
GO:0043467	regulation of generation of precursor metabolites and energy	0.041086982107044444	0.041086982107044444	+1	TP53,AKT1,EP300,NCOR1
GO:0044270	cellular nitrogen compound catabolic process	0.04121462741887167	0.04121462741887167	+1	CDKN2A,NPM1,RPL22,AKT1,ATM,TET2,PPP2R1A,RPL5,AXIN2
GO:0043470	regulation of carbohydrate catabolic process	0.04133203268342165	0.04133203268342165	+1	TP53,EP300,NCOR1
GO:0034101	erythrocyte homeostasis	0.04133203268342165	0.04133203268342165	+1	KIT,ACVR1B,ACVR2A
GO:0033500	carbohydrate homeostasis	0.041972370038148424	0.041972370038148424	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:0046686	response to cadmium ion	0.04202100988919323	0.04202100988919323	+1	EGFR,AKT1
GO:0001658	branching involved in ureteric bud morphogenesis	0.04202100988919323	0.04202100988919323	+1	SOX9,WT1
GO:0042307	positive regulation of protein import into nucleus	0.04202100988919323	0.04202100988919323	+1	PIK3R1,CDH1
GO:0060416	response to growth hormone	0.04202100988919323	0.04202100988919323	+1	PIK3R1,AKT1
GO:0000186	activation of MAPKK activity	0.04202100988919323	0.04202100988919323	+1	BRAF,LRRK2
GO:0043303	mast cell degranulation	0.04202100988919323	0.04202100988919323	+1	PIK3CG,KIT
GO:0061515	myeloid cell development	0.04202100988919323	0.04202100988919323	+1	FBXW7,KIT
GO:0055094	response to lipoprotein particle	0.04202100988919323	0.04202100988919323	+1	AKT1,TLR4
GO:0014015	positive regulation of gliogenesis	0.04202100988919323	0.04202100988919323	+1	NOTCH1,MIR142
GO:0046633	alpha-beta T cell proliferation	0.04202100988919323	0.04202100988919323	+1	TGFBR2,MAPK8IP1
GO:0001942	hair follicle development	0.04202100988919323	0.04202100988919323	+1	SOX9,FGFR2
GO:0098815	modulation of excitatory postsynaptic potential	0.04202100988919323	0.04202100988919323	+1	PTEN,LRRK2
GO:0055007	cardiac muscle cell differentiation	0.04232936278823199	0.04232936278823199	+1	WT1,PDGFRA,SMAD4
GO:0007272	ensheathment of neurons	0.04232936278823199	0.04232936278823199	+1	PTEN,NF1,PRX
GO:0010906	regulation of glucose metabolic process	0.04232936278823199	0.04232936278823199	+1	AKT1,EP300,FOXA2
GO:0035710	CD4-positive, alpha-beta T cell activation	0.04232936278823199	0.04232936278823199	+1	RUNX1,TGFBR2,CBFB
GO:0008366	axon ensheathment	0.04232936278823199	0.04232936278823199	+1	PTEN,NF1,PRX
GO:0010975	regulation of neuron projection development	0.04288223072522931	0.04288223072522931	+1	PTEN,ARHGAP35,EPHA3,AKT1,LRRK2,EP300
GO:0042098	T cell proliferation	0.04347642935592128	0.04347642935592128	+1	CDKN2A,PIK3CG,TGFBR2,MAPK8IP1
GO:0002218	activation of innate immune response	0.04347642935592128	0.04347642935592128	+1	KRAS,NRAS,EP300,SIN3A
GO:0030282	bone mineralization	0.04360318954364452	0.04360318954364452	+1	FGFR2,FGFR3,ACVR2A
GO:0051983	regulation of chromosome segregation	0.04360318954364452	0.04360318954364452	+1	APC,RB1,ATM
GO:0042542	response to hydrogen peroxide	0.04360318954364452	0.04360318954364452	+1	NFE2L2,HGF,LRRK2
GO:0032204	regulation of telomere maintenance	0.04360318954364452	0.04360318954364452	+1	ATM,ATRX,ATR
GO:0002448	mast cell mediated immunity	0.044211937370352096	0.044211937370352096	+1	PIK3CG,KIT
GO:0031018	endocrine pancreas development	0.044211937370352096	0.044211937370352096	+1	AKT1,FOXA2
GO:0022405	hair cycle process	0.044211937370352096	0.044211937370352096	+1	SOX9,FGFR2
GO:0042472	inner ear morphogenesis	0.044211937370352096	0.044211937370352096	+1	SOX9,FGFR2
GO:0071402	cellular response to lipoprotein particle stimulus	0.044211937370352096	0.044211937370352096	+1	AKT1,TLR4
GO:2000352	negative regulation of endothelial cell apoptotic process	0.044211937370352096	0.044211937370352096	+1	GATA3,NFE2L2
GO:0008156	negative regulation of DNA replication	0.044211937370352096	0.044211937370352096	+1	CHEK2,ATR
GO:0002279	mast cell activation involved in immune response	0.044211937370352096	0.044211937370352096	+1	PIK3CG,KIT
GO:0006470	protein dephosphorylation	0.044211937370352096	0.044211937370352096	+1	PTEN,STK11,MTOR,PPP2R1A,PTPN11
GO:0021761	limbic system development	0.044211937370352096	0.044211937370352096	+1	PTEN,FGFR2
GO:1901889	negative regulation of cell junction assembly	0.044211937370352096	0.044211937370352096	+1	PTEN,MIR142
GO:0022404	molting cycle process	0.044211937370352096	0.044211937370352096	+1	SOX9,FGFR2
GO:0006368	transcription elongation from RNA polymerase II promoter	0.044742654427567655	0.044742654427567655	+1	SETD2,CDK12,ERCC2
GO:0019439	aromatic compound catabolic process	0.04558467774180153	0.04558467774180153	+1	CDKN2A,NPM1,RPL22,AKT1,ATM,TET2,PPP2R1A,RPL5,AXIN2
GO:0050767	regulation of neurogenesis	0.04572987825914709	0.04572987825914709	+1	PTEN,NF1,NOTCH1,CTNNB1,MIR142
GO:0043393	regulation of protein binding	0.04603305370485259	0.04603305370485259	+1	AKT1,LRRK2,CDKN1A,TAF1
GO:0042594	response to starvation	0.0460483984155185	0.0460483984155185	+1	TP53,MTOR,LRRK2,CDKN1A
GO:0032091	negative regulation of protein binding	0.0460483984155185	0.0460483984155185	+1	AKT1,LRRK2,CDKN1A
GO:0061001	regulation of dendritic spine morphogenesis	0.0460483984155185	0.0460483984155185	+1	PTEN,LRRK2
GO:1903955	positive regulation of protein targeting to mitochondrion	0.0460483984155185	0.0460483984155185	+1	FBXW7,BAP1
GO:1904893	negative regulation of receptor signaling pathway via STAT	0.0460483984155185	0.0460483984155185	+1	VHL,PPP2R1A
GO:0034401	chromatin organization involved in regulation of transcription	0.0460483984155185	0.0460483984155185	+1	ARID1A,CDKN2A,SIN3A,EZH2
GO:0048146	positive regulation of fibroblast proliferation	0.0460483984155185	0.0460483984155185	+1	PDGFRA,CDKN1A
GO:1904591	positive regulation of protein import	0.0460483984155185	0.0460483984155185	+1	PIK3R1,CDH1
GO:0045589	regulation of regulatory T cell differentiation	0.0460483984155185	0.0460483984155185	+1	RUNX1,CBFB
GO:0016241	regulation of macroautophagy	0.0460483984155185	0.0460483984155185	+1	PIK3CA,AKT1,MTOR,LRRK2
GO:1905207	regulation of cardiocyte differentiation	0.0460483984155185	0.0460483984155185	+1	EGFR,SMAD4
GO:2000144	positive regulation of DNA-templated transcription, initiation	0.0460483984155185	0.0460483984155185	+1	TP53,CTNNB1
GO:0042116	macrophage activation	0.04643470826962676	0.04643470826962676	+1	CEBPA,TLR4,MIR142
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	0.04643470826962676	0.04643470826962676	+1	NFE2L2,AKT1,LRRK2
GO:0001704	formation of primary germ layer	0.04643470826962676	0.04643470826962676	+1	SETD2,SOX17,SMAD2
GO:0035767	endothelial cell chemotaxis	0.04676734179314137	0.04676734179314137	+1	NOTCH1,EGR3
GO:0050982	detection of mechanical stimulus	0.04676734179314137	0.04676734179314137	+1	CTNNB1,KIT
GO:1905898	positive regulation of response to endoplasmic reticulum stress	0.04676734179314137	0.04676734179314137	+1	PIK3R1,NFE2L2
GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	0.04676734179314137	0.04676734179314137	+1	BRCA1,NCOR1
GO:1902745	positive regulation of lamellipodium organization	0.04676734179314137	0.04676734179314137	+1	PIK3CA,PIK3R1
GO:0032212	positive regulation of telomere maintenance via telomerase	0.04676734179314137	0.04676734179314137	+1	ATM,ATR
GO:0098773	skin epidermis development	0.04676734179314137	0.04676734179314137	+1	SOX9,FGFR2
GO:0032728	positive regulation of interferon-beta production	0.04676734179314137	0.04676734179314137	+1	TLR4,PTPN11
GO:0048009	insulin-like growth factor receptor signaling pathway	0.04676734179314137	0.04676734179314137	+1	PIK3R1,AKT1
GO:0051443	positive regulation of ubiquitin-protein transferase activity	0.04676734179314137	0.04676734179314137	+1	PTEN,FBXW7
GO:0035510	DNA dealkylation	0.04676734179314137	0.04676734179314137	+1	TET2,USP9X
GO:0042058	regulation of epidermal growth factor receptor signaling pathway	0.047532730257932365	0.047532730257932365	+1	EGFR,FBXW7,AKT1
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	0.047532730257932365	0.047532730257932365	+1	AKT1,AR,BRCA1
GO:2001251	negative regulation of chromosome organization	0.047532730257932365	0.047532730257932365	+1	APC,ATM,ATRX
GO:0006476	protein deacetylation	0.047532730257932365	0.047532730257932365	+1	EP300,SIN3A,TBL1XR1
GO:0043010	camera-type eye development	0.049149952610242464	0.049149952610242464	+1	NF1,SOX9,WT1,PDGFRA
GO:0097028	dendritic cell differentiation	0.04921923460630913	0.04921923460630913	+1	FLT3,TGFBR2
GO:0032148	activation of protein kinase B activity	0.04921923460630913	0.04921923460630913	+1	AKT1,MTOR
GO:0045066	regulatory T cell differentiation	0.04921923460630913	0.04921923460630913	+1	RUNX1,CBFB
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	0.04921923460630913	0.04921923460630913	+1	MAP3K1,TLR4
GO:0006298	mismatch repair	0.04921923460630913	0.04921923460630913	+1	SETD2,AXIN2
GO:0006361	transcription initiation from RNA polymerase I promoter	0.04921923460630913	0.04921923460630913	+1	TAF1,ERCC2
GO:0010543	regulation of platelet activation	0.04921923460630913	0.04921923460630913	+1	TLR4,PDGFRA
GO:0046636	negative regulation of alpha-beta T cell activation	0.04921923460630913	0.04921923460630913	+1	RUNX1,CBFB
GO:0034504	protein localization to nucleus	0.0496815846035946	0.0496815846035946	+1	PIK3R1,CDKN2A,CDH1,AKT1,SIN3A
GO:0015031	protein transport	0.049925856843952336	0.049925856843952336	+1	TP53,PIK3R1,CDKN2A,FBXW7,CDH1,BAP1,NPM1,IDH1,RPL22,AKT1,TLR4,U2AF1,LRRK2,SETD2,FOXA2,USP9X,RPL5
REAC:R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	1.3313863315873152e-14	1.3313863315873152e-14	+1	PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,NOTCH1,CTNNB1,NRAS,AKT1,BRAF,CDKN1B,HGF,MTOR,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,PPP2R1A,PTPN11,TBL1XR1,NCOR1,SMAD2
REAC:R-HSA-212436	Generic Transcription Pathway	8.742359112877474e-12	8.742359112877474e-12	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,NPM1,RUNX1,STK11,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-74160	Gene expression (Transcription)	8.931766337755961e-12	8.931766337755961e-12	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,NPM1,RUNX1,STK11,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,U2AF1,TET2,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-73857	RNA Polymerase II Transcription	2.538328669708868e-11	2.538328669708868e-11	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,NPM1,RUNX1,STK11,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,U2AF1,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-8939211	ESR-mediated signaling	3.585345310008184e-10	3.585345310008184e-10	+1	PIK3CA,EGFR,PIK3R1,GATA3,RUNX1,NRAS,AKT1,STAG2,CDKN1B,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-1643685	Disease	6.350852629496512e-10	6.350852629496512e-10	+1	PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,CTNNB1,CDH1,NPM1,NRAS,IDH1,MAP2K4,RPL22,AKT1,BRAF,CDKN1B,HGF,MTOR,TLR4,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,HIST1H2BD,PTPN11,TBL1XR1,NCOR1,RPL5,SMAD2,ERCC2,EZH2
REAC:R-HSA-9006931	Signaling by Nuclear Receptors	7.210703713341906e-10	7.210703713341906e-10	+1	PIK3CA,EGFR,PIK3R1,GATA3,RUNX1,NRAS,AKT1,STAG2,CDKN1B,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,TBL1XR1,SMC3,NCOR1,RAD21
REAC:R-HSA-2219528	PI3K/AKT Signaling in Cancer	6.975240016761726e-9	6.975240016761726e-9	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PTPN11
REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	1.9191681851203434e-7	1.9191681851203434e-7	+1	TP53,KRAS,CDKN2A,NOTCH1,CTNNB1,RUNX1,EP300,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-1257604	PIP3 activates AKT signaling	2.465873448035676e-7	2.465873448035676e-7	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PPP2R1A,PTPN11,MECOM,EZH2
REAC:R-HSA-162582	Signal Transduction	3.1146498050369425e-7	3.1146498050369425e-7	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,NRAS,STK11,AKT1,STAG2,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,MTOR,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,CCND1,SMAD4,USP9X,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,HIST1H2BD,SMC1A,PTPN11,ACVR1B,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,SMAD2,SPOP,AXIN2,RAD21,EZH2
REAC:R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	3.1463160947103546e-7	3.1463160947103546e-7	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-8951936	RUNX3 regulates p14-ARF	3.3182436348980883e-7	3.3182436348980883e-7	+1	KRAS,RUNX1,EP300,CCND1,CBFB
REAC:R-HSA-2990846	SUMOylation	4.2762352320896153e-7	4.2762352320896153e-7	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-3247509	Chromatin modifying enzymes	5.223569545916483e-7	5.223569545916483e-7	+1	ARID1A,PBRM1,DNMT3A,KDM6A,KDM5C,ARID5B,SETD2,EP300,CCND1,HIST1H2BD,NSD1,TBL1XR1,MECOM,NCOR1,EZH2
REAC:R-HSA-4839726	Chromatin organization	5.223569545916483e-7	5.223569545916483e-7	+1	ARID1A,PBRM1,DNMT3A,KDM6A,KDM5C,ARID5B,SETD2,EP300,CCND1,HIST1H2BD,NSD1,TBL1XR1,MECOM,NCOR1,EZH2
REAC:R-HSA-9018519	Estrogen-dependent gene expression	6.288841866990198e-7	6.288841866990198e-7	+1	GATA3,RUNX1,STAG2,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-5688426	Deubiquitination	6.288841866990198e-7	6.288841866990198e-7	+1	TP53,PTEN,APC,GATA3,KEAP1,BAP1,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,HIST1H2BD,SMAD2,AXIN2
REAC:R-HSA-3700989	Transcriptional Regulation by TP53	6.459661103905041e-7	6.459661103905041e-7	+1	TP53,PTEN,CDKN2A,NPM1,STK11,AKT1,ATM,CDKN1B,MTOR,BRCA1,CHEK2,EP300,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,ERCC2
REAC:R-HSA-9006925	Intracellular signaling by second messengers	0.0000010361120405444228	0.0000010361120405444228	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PPP2R1A,PTPN11,MECOM,EZH2
REAC:R-HSA-199418	Negative regulation of the PI3K/AKT network	0.000001451831821078544	0.000001451831821078544	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-6804757	Regulation of TP53 Degradation	0.0000021059854397789887	0.0000021059854397789887	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-5633007	Regulation of TP53 Activity	0.0000021356021545759124	0.0000021356021545759124	+1	TP53,CDKN2A,STK11,AKT1,ATM,MTOR,BRCA1,CHEK2,EP300,TAF1,PPP2R1A,ATR
REAC:R-HSA-1640170	Cell Cycle	0.0000021356021545759124	0.0000021356021545759124	+1	TP53,CDKN2A,RB1,NPM1,AKT1,STAG2,AJUBA,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CCND1,BRCA2,CDKN1A,PPP2R1A,ATR,HIST1H2BD,SMC1A,SMC3,RAD21,CDKN2C
REAC:R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.000002267120013745012	0.000002267120013745012	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-1266738	Developmental Biology	0.000003152824569516385	0.000003152824569516385	+1	PIK3CA,EGFR,PIK3R1,NOTCH1,CTNNB1,ARHGAP35,CTCF,RUNX1,NRAS,RPL22,CEBPA,KDM6A,EPHA3,AKT1,AJUBA,PRX,EP300,SMAD4,FOXA2,CDKN1A,CBFB,HIST1H2BD,PTPN11,ACVR1B,TBL1XR1,ACVR2A,NCOR1,RPL5,SMAD2,EZH2
REAC:R-HSA-1500620	Meiosis	0.000003216763529196903	0.000003216763529196903	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.000007075616636132061	0.000007075616636132061	+1	PIK3CA,EGFR,PIK3R1,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-9614085	FOXO-mediated transcription	0.000008046747834633138	0.000008046747834633138	+1	STK11,AKT1,CDKN1B,EP300,SMAD4,CDKN1A,SIN3A,SMAD2
REAC:R-HSA-69231	Cyclin D associated events in G1	0.000008832288678545343	0.000008832288678545343	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-69236	G1 Phase	0.000008832288678545343	0.000008832288678545343	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	0.00001624499526611684	0.00001624499526611684	+1	EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
REAC:R-HSA-8848021	Signaling by PTK6	0.00001624499526611684	0.00001624499526611684	+1	EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
REAC:R-HSA-8853334	Signaling by FGFR3 fusions in cancer	0.00001624499526611684	0.00001624499526611684	+1	PIK3CA,PIK3R1,NRAS,FGFR3
REAC:R-HSA-5654741	Signaling by FGFR3	0.00001624499526611684	0.00001624499526611684	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-1221632	Meiotic synapsis	0.00002357584447336096	0.00002357584447336096	+1	STAG2,BRCA1,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-1474165	Reproduction	0.000025358048446422353	0.000025358048446422353	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-5654743	Signaling by FGFR4	0.000025358048446422353	0.000025358048446422353	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.00003170316228194137	0.00003170316228194137	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-9673770	Signaling by PDGFRA extracellular domain mutants	0.00003930172588406564	0.00003930172588406564	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
REAC:R-HSA-9673767	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	0.00003930172588406564	0.00003930172588406564	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
REAC:R-HSA-2470946	Cohesin Loading onto Chromatin	0.00003930172588406564	0.00003930172588406564	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-5654736	Signaling by FGFR1	0.00004814810616984408	0.00004814810616984408	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5684996	MAPK1/MAPK3 signaling	0.00004814810616984408	0.00004814810616984408	+1	PIK3CA,KRAS,EGFR,NF1,PIK3R1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-8878166	Transcriptional regulation by RUNX2	0.00004814810616984408	0.00004814810616984408	+1	RB1,RUNX1,AKT1,AR,SOX9,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.00004814810616984408	0.00004814810616984408	+1	PIK3CA,EGFR,PIK3R1,HGF,KIT,PDGFRA,PTPN11
REAC:R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.00005476715270595845	0.00005476715270595845	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-9607240	FLT3 Signaling	0.00006636427187228565	0.00006636427187228565	+1	PIK3CA,KRAS,EGFR,NF1,PIK3R1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-2559583	Cellular Senescence	0.00006995649612760117	0.00006995649612760117	+1	TP53,CDKN2A,RB1,MAP2K4,ATM,CDKN1B,CDKN1A,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-157118	Signaling by NOTCH	0.00007000128772080635	0.00007000128772080635	+1	TP53,EGFR,NOTCH1,RUNX1,AKT1,ELF3,EP300,CCND1,HIST1H2BD,TBL1XR1,NCOR1
REAC:R-HSA-8878171	Transcriptional regulation by RUNX1	0.00007940453167491549	0.00007940453167491549	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,CCND1,CBFB,SIN3A,HIST1H2BD,PTPN11,LIFR
REAC:R-HSA-186763	Downstream signal transduction	0.00008448840640781607	0.00008448840640781607	+1	PIK3CA,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.0000896871384722303	0.0000896871384722303	+1	PIK3CA,EGFR,PIK3R1,CTNNB1,FLT3,NRAS,AKT1,BRAF,HGF,MTOR,KIT,PDGFRA,EP300,PPP2R1A,PTPN11,EGR3,NCOR1
REAC:R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.00009635243195113578	0.00009635243195113578	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-1502540	Signaling by Activin	0.00009635243195113578	0.00009635243195113578	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-68884	Mitotic Telophase/Cytokinesis	0.00009635243195113578	0.00009635243195113578	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.00009635243195113578	0.00009635243195113578	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-2262752	Cellular responses to stress	0.00009844322645000539	0.00009844322645000539	+1	TP53,VHL,CDKN2A,RB1,MAP2K4,RPL22,AR,AJUBA,ATM,CDKN1B,MTOR,EP300,CDKN1A,ATR,HIST1H2BD,RPL5,CDKN2C,EZH2
REAC:R-HSA-9009391	Extra-nuclear estrogen signaling	0.00011147545360912324	0.00011147545360912324	+1	PIK3CA,EGFR,PIK3R1,NRAS,AKT1,CDKN1B,CCND1
REAC:R-HSA-1912422	Pre-NOTCH Expression and Processing	0.00011147545360912324	0.00011147545360912324	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-9665348	Signaling by ERBB2 ECD mutants	0.00012508369218155866	0.00012508369218155866	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	0.0001289689723481336	0.0001289689723481336	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	0.0001289689723481336	0.0001289689723481336	+1	RUNX1,CBFB,LIFR
REAC:R-HSA-8851907	MET activates PI3K/AKT signaling	0.0001289689723481336	0.0001289689723481336	+1	PIK3CA,PIK3R1,HGF
REAC:R-HSA-8953897	Cellular responses to external stimuli	0.0001289689723481336	0.0001289689723481336	+1	TP53,VHL,CDKN2A,RB1,MAP2K4,RPL22,AR,AJUBA,ATM,CDKN1B,MTOR,EP300,CDKN1A,ATR,HIST1H2BD,RPL5,CDKN2C,EZH2
REAC:R-HSA-5683057	MAPK family signaling cascades	0.00014693701998285275	0.00014693701998285275	+1	PIK3CA,KRAS,EGFR,NF1,PIK3R1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-5673001	RAF/MAP kinase cascade	0.00015429784528827375	0.00015429784528827375	+1	PIK3CA,KRAS,EGFR,NF1,PIK3R1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A
REAC:R-HSA-5693532	DNA Double-Strand Break Repair	0.00017267418559805463	0.00017267418559805463	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-9616222	Transcriptional regulation of granulopoiesis	0.00017267418559805463	0.00017267418559805463	+1	RUNX1,CEBPA,EP300,CDKN1A,CBFB,HIST1H2BD
REAC:R-HSA-212165	Epigenetic regulation of gene expression	0.00017717879390094152	0.00017717879390094152	+1	DNMT3A,TET2,EP300,SF3B1,SIN3A,HIST1H2BD,ERCC2,EZH2
REAC:R-HSA-210993	Tie2 Signaling	0.00018974387191892663	0.00018974387191892663	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-180292	GAB1 signalosome	0.00018974387191892663	0.00018974387191892663	+1	PIK3CA,EGFR,PIK3R1,PTPN11
REAC:R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.0002045731618067913	0.0002045731618067913	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-9670439	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	0.0002045731618067913	0.0002045731618067913	+1	PIK3CA,PIK3R1,NRAS,KIT
REAC:R-HSA-8941855	RUNX3 regulates CDKN1A transcription	0.0002045731618067913	0.0002045731618067913	+1	TP53,SMAD4,CDKN1A
REAC:R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.0002045731618067913	0.0002045731618067913	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-8934593	Regulation of RUNX1 Expression and Activity	0.0002045731618067913	0.0002045731618067913	+1	RUNX1,CCND1,CBFB,PTPN11
REAC:R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.0002045731618067913	0.0002045731618067913	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.0002045731618067913	0.0002045731618067913	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-9669938	Signaling by KIT in disease	0.0002045731618067913	0.0002045731618067913	+1	PIK3CA,PIK3R1,NRAS,KIT
REAC:R-HSA-9659787	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	0.0002045731618067913	0.0002045731618067913	+1	RB1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	0.0002045731618067913	0.0002045731618067913	+1	RB1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-5619507	Activation of HOX genes during differentiation	0.0002045731618067913	0.0002045731618067913	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-9617828	FOXO-mediated transcription of cell cycle genes	0.0002045731618067913	0.0002045731618067913	+1	CDKN1B,SMAD4,CDKN1A,SMAD2
REAC:R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.0002045731618067913	0.0002045731618067913	+1	TP53,RB1,ATM,CDKN1B,CDKN1A,HIST1H2BD
REAC:R-HSA-5655332	Signaling by FGFR3 in disease	0.0002045731618067913	0.0002045731618067913	+1	PIK3CA,PIK3R1,NRAS,FGFR3
REAC:R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.0002045731618067913	0.0002045731618067913	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	0.0002045731618067913	0.0002045731618067913	+1	PIK3CA,PIK3R1,NRAS,FGFR3
REAC:R-HSA-5693606	DNA Double Strand Break Response	0.00022380577660933258	0.00022380577660933258	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.0002243581137307572	0.0002243581137307572	+1	EGFR,NPM1,KIT,EP300,CDKN1A
REAC:R-HSA-9671555	Signaling by PDGFR in disease	0.00024586586731494226	0.00024586586731494226	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
REAC:R-HSA-5654708	Downstream signaling of activated FGFR3	0.00024586586731494226	0.00024586586731494226	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	0.0002501554932695648	0.0002501554932695648	+1	ARID1A,PBRM1,RUNX1,EP300,CBFB
REAC:R-HSA-5689880	Ub-specific processing proteases	0.0002738668550122035	0.0002738668550122035	+1	TP53,PTEN,GATA3,KEAP1,AR,SMAD4,USP9X,HIST1H2BD,SMAD2,AXIN2
REAC:R-HSA-6804760	Regulation of TP53 Activity through Methylation	0.0002992912069702201	0.0002992912069702201	+1	TP53,ATM,CHEK2,EP300
REAC:R-HSA-69242	S Phase	0.000300704272115426	0.000300704272115426	+1	RB1,AKT1,STAG2,CDKN1B,CCND1,CDKN1A,SMC1A,SMC3,RAD21
REAC:R-HSA-1433557	Signaling by SCF-KIT	0.0003143258650946665	0.0003143258650946665	+1	PIK3CA,PIK3R1,NRAS,KIT,PTPN11
REAC:R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.00031438955994650495	0.00031438955994650495	+1	TP53,STK11,ATM,BRCA1,CHEK2,TAF1,ATR
REAC:R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.0003244354539760436	0.0003244354539760436	+1	TP53,ATM,BRCA1,ATR,CDK12,ERCC2
REAC:R-HSA-5654738	Signaling by FGFR2	0.0003457780355776434	0.0003457780355776434	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-1181150	Signaling by NODAL	0.0003457780355776434	0.0003457780355776434	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-112399	IRS-mediated signalling	0.0003457780355776434	0.0003457780355776434	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-166520	Signaling by NTRKs	0.000375451014496571	0.000375451014496571	+1	PIK3CA,PIK3R1,NRAS,BRAF,EP300,PPP2R1A,PTPN11,EGR3
REAC:R-HSA-69278	Cell Cycle, Mitotic	0.000375451014496571	0.000375451014496571	+1	TP53,CDKN2A,RB1,AKT1,STAG2,AJUBA,CDKN1B,EP300,CCND1,CDKN1A,PPP2R1A,HIST1H2BD,SMC1A,SMC3,RAD21,CDKN2C
REAC:R-HSA-69563	p53-Dependent G1 DNA Damage Response	0.0003955371798397635	0.0003955371798397635	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	0.0003955371798397635	0.0003955371798397635	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-9006115	Signaling by NTRK2 (TRKB)	0.0004003271448062712	0.0004003271448062712	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-9664565	Signaling by ERBB2 KD Mutants	0.0004003271448062712	0.0004003271448062712	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-388841	Costimulation by the CD28 family	0.00041910252842641555	0.00041910252842641555	+1	PIK3CA,PIK3R1,AKT1,MTOR,PPP2R1A,PTPN11
REAC:R-HSA-69615	G1/S DNA Damage Checkpoints	0.00045104207950285354	0.00045104207950285354	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.00045104207950285354	0.00045104207950285354	+1	APC,CTNNB1,AKT1,SOX9,SOX17
REAC:R-HSA-5654687	Downstream signaling of activated FGFR1	0.00045475742079281885	0.00045475742079281885	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.00045475742079281885	0.00045475742079281885	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-1227990	Signaling by ERBB2 in Cancer	0.00045475742079281885	0.00045475742079281885	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-9006936	Signaling by TGFB family members	0.00045475742079281885	0.00045475742079281885	+1	SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,NCOR1,SMAD2
REAC:R-HSA-5654716	Downstream signaling of activated FGFR4	0.00045475742079281885	0.00045475742079281885	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-2428924	IGF1R signaling cascade	0.0004763374257246179	0.0004763374257246179	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-2428928	IRS-related events triggered by IGF1R	0.0004763374257246179	0.0004763374257246179	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.0005080257992803248	0.0005080257992803248	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-5654696	Downstream signaling of activated FGFR2	0.0005080257992803248	0.0005080257992803248	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-1643713	Signaling by EGFR in Cancer	0.0005080257992803248	0.0005080257992803248	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-1280215	Cytokine Signaling in Immune system	0.0005080257992803248	0.0005080257992803248	+1	TP53,PIK3CA,KRAS,EGFR,NF1,PIK3R1,GATA3,FLT3,NRAS,MAP2K4,AKT1,BRAF,HGF,KIT,PDGFRA,CCND1,CDKN1A,PPP2R1A,EIF4A2,PTPN11,LIFR
REAC:R-HSA-9006335	Signaling by Erythropoietin	0.0005080257992803248	0.0005080257992803248	+1	PIK3CA,PIK3R1,NRAS,PIK3CG
REAC:R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.0005080257992803248	0.0005080257992803248	+1	SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-5655291	Signaling by FGFR4 in disease	0.0005452584748323923	0.0005452584748323923	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	0.0005452584748323923	0.0005452584748323923	+1	CDKN2A,STAG2,BRCA1,SMC1A,SMC3,RAD21
REAC:R-HSA-74751	Insulin receptor signalling cascade	0.0005529411505669267	0.0005529411505669267	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	0.0005860735673204506	0.0005860735673204506	+1	EGFR,AKT1,CDKN1B,CCND1
REAC:R-HSA-1227986	Signaling by ERBB2	0.0006059550582548777	0.0006059550582548777	+1	PIK3CA,EGFR,PIK3R1,NRAS,AKT1
REAC:R-HSA-190236	Signaling by FGFR	0.0006166271751626371	0.0006166271751626371	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-69473	G2/M DNA damage checkpoint	0.0007106342800559513	0.0007106342800559513	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-177929	Signaling by EGFR	0.0007269345971188303	0.0007269345971188303	+1	PIK3CA,EGFR,PIK3R1,NRAS,PTPN11
REAC:R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.0007269345971188303	0.0007269345971188303	+1	TP53,PIK3R1,GATA3,AKT1,HGF,CCND1,CDKN1A
REAC:R-HSA-453279	Mitotic G1 phase and G1/S transition	0.0007291905282871463	0.0007291905282871463	+1	CDKN2A,RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.0007699262048102864	0.0007699262048102864	+1	AKT1,CDKN1B,MTOR,CDKN1A
REAC:R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.0007808721907238874	0.0007808721907238874	+1	TP53,NPM1,CDKN1B,EP300,CDKN1A
REAC:R-HSA-187037	Signaling by NTRK1 (TRKA)	0.0007904779194611962	0.0007904779194611962	+1	PIK3CA,PIK3R1,NRAS,BRAF,EP300,PPP2R1A,EGR3
REAC:R-HSA-201681	TCF dependent signaling in response to WNT	0.0009142822490477158	0.0009142822490477158	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
REAC:R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	0.0009324979099396269	0.0009324979099396269	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9005895	Pervasive developmental disorders	0.0009324979099396269	0.0009324979099396269	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9675151	Disorders of Developmental Biology	0.0009324979099396269	0.0009324979099396269	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9697154	Disorders of Nervous System Development	0.0009324979099396269	0.0009324979099396269	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-1236394	Signaling by ERBB4	0.001175841710444705	0.001175841710444705	+1	PIK3CA,EGFR,PIK3R1,NRAS,NCOR1
REAC:R-HSA-186797	Signaling by PDGF	0.001175841710444705	0.001175841710444705	+1	PIK3CA,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.0012087983444511643	0.0012087983444511643	+1	PIK3CA,PIK3R1,PIK3CG
REAC:R-HSA-8941326	RUNX2 regulates bone development	0.0012570810417284147	0.0012570810417284147	+1	RB1,AR,SMAD4,CBFB
REAC:R-HSA-73894	DNA Repair	0.0012570810417284147	0.0012570810417284147	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,EP300,BRCA2,ATR,HIST1H2BD,ERCC2
REAC:R-HSA-2559580	Oxidative Stress Induced Senescence	0.0013301529275907638	0.0013301529275907638	+1	TP53,CDKN2A,MAP2K4,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-1226099	Signaling by FGFR in disease	0.0013511191324425123	0.0013511191324425123	+1	PIK3CA,PIK3R1,NRAS,FGFR2,FGFR3
REAC:R-HSA-389356	CD28 co-stimulation	0.0014036755505549734	0.0014036755505549734	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-9034015	Signaling by NTRK3 (TRKC)	0.0014785023617168596	0.0014785023617168596	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-1963642	PI3K events in ERBB2 signaling	0.0014785023617168596	0.0014785023617168596	+1	PIK3CA,EGFR,PIK3R1
REAC:R-HSA-5654710	PI-3K cascade:FGFR3	0.0014785023617168596	0.0014785023617168596	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-2559585	Oncogene Induced Senescence	0.001696017334785446	0.001696017334785446	+1	TP53,CDKN2A,RB1,CDKN2C
REAC:R-HSA-198323	AKT phosphorylates targets in the cytosol	0.0017643444125299017	0.0017643444125299017	+1	AKT1,CDKN1B,CDKN1A
REAC:R-HSA-1295596	Spry regulation of FGF signaling	0.0017643444125299017	0.0017643444125299017	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.0017643444125299017	0.0017643444125299017	+1	TP53,CDKN1B,CDKN1A
REAC:R-HSA-597592	Post-translational protein modification	0.0018268950431265824	0.0018268950431265824	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,DNMT3A,KEAP1,BAP1,NPM1,STAG2,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,B4GALT3,SIN3A,HIST1H2BD,SMC1A,SMC3,SMAD2,AXIN2,RAD21
REAC:R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.0018268950431265824	0.0018268950431265824	+1	PIK3CA,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	0.0018268950431265824	0.0018268950431265824	+1	RUNX1,EP300,CBFB,SIN3A,HIST1H2BD
REAC:R-HSA-69620	Cell Cycle Checkpoints	0.0019147296778533156	0.0019147296778533156	+1	TP53,CDKN2A,ATM,CDKN1B,BRCA1,CHEK2,CDKN1A,PPP2R1A,ATR,HIST1H2BD
REAC:R-HSA-114604	GPVI-mediated activation cascade	0.002034885563590666	0.002034885563590666	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
REAC:R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	0.002038496924283495	0.002038496924283495	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-4839743	Signaling by CTNNB1 phospho-site mutants	0.002038496924283495	0.002038496924283495	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	0.002038496924283495	0.002038496924283495	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	0.002038496924283495	0.002038496924283495	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	0.002038496924283495	0.002038496924283495	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5339716	Signaling by GSK3beta mutants	0.002038496924283495	0.002038496924283495	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5654689	PI-3K cascade:FGFR1	0.002038496924283495	0.002038496924283495	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	0.0021434806081939988	0.0021434806081939988	+1	RB1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-109704	PI3K Cascade	0.0021434806081939988	0.0021434806081939988	+1	PIK3CA,PIK3R1,FLT3,PTPN11
REAC:R-HSA-9675126	Diseases of mitotic cell cycle	0.0021434806081939988	0.0021434806081939988	+1	RB1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-5655253	Signaling by FGFR2 in disease	0.0023716212463400837	0.0023716212463400837	+1	PIK3CA,PIK3R1,NRAS,FGFR2
REAC:R-HSA-69895	Transcriptional  activation of  cell cycle inhibitor p21 	0.0027643999466987726	0.0027643999466987726	+1	TP53,CDKN1A
REAC:R-HSA-69560	Transcriptional activation of p53 responsive genes  	0.0027643999466987726	0.0027643999466987726	+1	TP53,CDKN1A
REAC:R-HSA-186712	Regulation of beta-cell development	0.0027643999466987726	0.0027643999466987726	+1	NOTCH1,AKT1,EP300,FOXA2
REAC:R-HSA-8853884	Transcriptional Regulation by VENTX	0.0027643999466987726	0.0027643999466987726	+1	TP53,CDKN2A,CTNNB1,CCND1
REAC:R-HSA-196299	Beta-catenin phosphorylation cascade	0.0027643999466987726	0.0027643999466987726	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-8865999	MET activates PTPN11	0.0027643999466987726	0.0027643999466987726	+1	HGF,PTPN11
REAC:R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.0027643999466987726	0.0027643999466987726	+1	TGFBR2,SMAD2
REAC:R-HSA-5654720	PI-3K cascade:FGFR4	0.0027643999466987726	0.0027643999466987726	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-194138	Signaling by VEGF	0.0027643999466987726	0.0027643999466987726	+1	PIK3CA,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.0027643999466987726	0.0027643999466987726	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-3656532	TGFBR1 KD Mutants in Cancer	0.0027643999466987726	0.0027643999466987726	+1	TGFBR2,SMAD2
REAC:R-HSA-74752	Signaling by Insulin receptor	0.002814347918432352	0.002814347918432352	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.0031928102122443618	0.0031928102122443618	+1	SMAD4,USP9X,TGFBR2,NCOR1,SMAD2
REAC:R-HSA-5654695	PI-3K cascade:FGFR2	0.003241885291420237	0.003241885291420237	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.0035682194485684	0.0035682194485684	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.004240184239954288	0.004240184239954288	+1	SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.0042449626390722766	0.0042449626390722766	+1	CDKN2A,CDKN1B,CDKN1A,HIST1H2BD,CDKN2C
REAC:R-HSA-6806834	Signaling by MET	0.0042449626390722766	0.0042449626390722766	+1	PIK3CA,PIK3R1,NRAS,HGF,PTPN11
REAC:R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.004285460693384236	0.004285460693384236	+1	CTNNB1,EP300
REAC:R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	0.004285460693384236	0.004285460693384236	+1	TGFBR2,SMAD2
REAC:R-HSA-389513	CTLA4 inhibitory signaling	0.004285460693384236	0.004285460693384236	+1	AKT1,PPP2R1A,PTPN11
REAC:R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	0.004285460693384236	0.004285460693384236	+1	RUNX1,CBFB
REAC:R-HSA-3214858	RMTs methylate histone arginines	0.004457701044814088	0.004457701044814088	+1	ARID1A,PBRM1,DNMT3A,CCND1
REAC:R-HSA-5693538	Homology Directed Repair	0.004747113256492607	0.004747113256492607	+1	ATM,BRCA1,POLQ,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-3214841	PKMTs methylate histone lysines	0.004773953203815542	0.004773953203815542	+1	SETD2,NSD1,MECOM,EZH2
REAC:R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.004773953203815542	0.004773953203815542	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-69202	Cyclin E associated events during G1/S transition 	0.005835301369765594	0.005835301369765594	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-9679514	SARS-CoV-1 Genome Replication and Transcription	0.005835301369765594	0.005835301369765594	+1	VHL,RB1
REAC:R-HSA-9645135	STAT5 Activation	0.005835301369765594	0.005835301369765594	+1	FLT3,PTPN11
REAC:R-HSA-8931987	RUNX1 regulates estrogen receptor mediated transcription	0.005835301369765594	0.005835301369765594	+1	RUNX1,CBFB
REAC:R-HSA-8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	0.005835301369765594	0.005835301369765594	+1	RUNX1,CBFB
REAC:R-HSA-8939245	RUNX1 regulates transcription of genes involved in BCR signaling	0.005835301369765594	0.005835301369765594	+1	RUNX1,CBFB
REAC:R-HSA-9682706	Replication of the SARS-CoV-1 genome	0.005835301369765594	0.005835301369765594	+1	VHL,RB1
REAC:R-HSA-8857538	PTK6 promotes HIF1A stabilization	0.005835301369765594	0.005835301369765594	+1	EGFR,LRRK2
REAC:R-HSA-9022537	Loss of MECP2 binding ability to the NCoR/SMRT complex	0.005835301369765594	0.005835301369765594	+1	TBL1XR1,NCOR1
REAC:R-HSA-8849470	PTK6 Regulates Cell Cycle	0.005835301369765594	0.005835301369765594	+1	CDKN1B,CCND1
REAC:R-HSA-6802953	RAS signaling downstream of NF1 loss-of-function variants	0.005835301369765594	0.005835301369765594	+1	NF1,NRAS
REAC:R-HSA-9603381	Activated NTRK3 signals through PI3K	0.005835301369765594	0.005835301369765594	+1	PIK3CA,PIK3R1
REAC:R-HSA-8939256	RUNX1 regulates transcription of genes involved in WNT signaling	0.005835301369765594	0.005835301369765594	+1	RUNX1,CBFB
REAC:R-HSA-9028335	Activated NTRK2 signals through PI3K	0.005835301369765594	0.005835301369765594	+1	PIK3CA,PIK3R1
REAC:R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.005922425957001974	0.005922425957001974	+1	RB1,AR,CBFB
REAC:R-HSA-5654732	Negative regulation of FGFR3 signaling	0.005922425957001974	0.005922425957001974	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-449147	Signaling by Interleukins	0.006214389832504429	0.006214389832504429	+1	TP53,PIK3CA,PIK3R1,GATA3,MAP2K4,AKT1,HGF,CCND1,CDKN1A,PPP2R1A,PTPN11,LIFR
REAC:R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.006214389832504429	0.006214389832504429	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-912446	Meiotic recombination	0.006438238669355999	0.006438238669355999	+1	ATM,BRCA1,BRCA2,HIST1H2BD
REAC:R-HSA-109581	Apoptosis	0.006846971625161299	0.006846971625161299	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,AKT1,TLR4
REAC:R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.00686040553228981	0.00686040553228981	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-3214842	HDMs demethylate histones	0.007347393389931622	0.007347393389931622	+1	KDM6A,KDM5C,ARID5B
REAC:R-HSA-2424491	DAP12 signaling	0.007347393389931622	0.007347393389931622	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-5357801	Programmed Cell Death	0.007415906553287728	0.007415906553287728	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,AKT1,TLR4
REAC:R-HSA-69206	G1/S Transition	0.007482430607613694	0.007482430607613694	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A
REAC:R-HSA-8941332	RUNX2 regulates genes involved in cell migration	0.007659599016324293	0.007659599016324293	+1	AKT1,CBFB
REAC:R-HSA-2179392	EGFR Transactivation by Gastrin	0.007659599016324293	0.007659599016324293	+1	EGFR,NRAS
REAC:R-HSA-5654726	Negative regulation of FGFR1 signaling	0.008033680849865332	0.008033680849865332	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.008033680849865332	0.008033680849865332	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.008122932395990608	0.008122932395990608	+1	CTNNB1,EP300,HIST1H2BD,AXIN2
REAC:R-HSA-5218920	VEGFR2 mediated vascular permeability	0.008858867852481196	0.008858867852481196	+1	CTNNB1,AKT1,MTOR
REAC:R-HSA-5654733	Negative regulation of FGFR4 signaling	0.008858867852481196	0.008858867852481196	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.008959873062982902	0.008959873062982902	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-69541	Stabilization of p53	0.008959873062982902	0.008959873062982902	+1	TP53,CDKN2A,ATM,CHEK2
REAC:R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.008959873062982902	0.008959873062982902	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.008959873062982902	0.008959873062982902	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.008959873062982902	0.008959873062982902	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.008959873062982902	0.008959873062982902	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-195721	Signaling by WNT	0.009082625946626937	0.009082625946626937	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
REAC:R-HSA-6807070	PTEN Regulation	0.009130358071094464	0.009130358071094464	+1	TP53,PTEN,AKT1,MTOR,MECOM,EZH2
REAC:R-HSA-8951430	RUNX3 regulates WNT signaling	0.009375384426272594	0.009375384426272594	+1	CTNNB1,CCND1
REAC:R-HSA-5654727	Negative regulation of FGFR2 signaling	0.009375384426272594	0.009375384426272594	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-350054	Notch-HLH transcription pathway	0.009375384426272594	0.009375384426272594	+1	NOTCH1,TBL1XR1,NCOR1
REAC:R-HSA-8851805	MET activates RAS signaling	0.009375384426272594	0.009375384426272594	+1	NRAS,HGF
REAC:R-HSA-8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	0.009375384426272594	0.009375384426272594	+1	RUNX1,CBFB
REAC:R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.009375384426272594	0.009375384426272594	+1	CTNNB1,AXIN2
REAC:R-HSA-9609690	HCMV Early Events	0.009376664936643679	0.009376664936643679	+1	EGFR,HIST1H2BD,TBL1XR1,NCOR1,EZH2
REAC:R-HSA-8943724	Regulation of PTEN gene transcription	0.009725878634518473	0.009725878634518473	+1	TP53,MTOR,MECOM,EZH2
REAC:R-HSA-8986944	Transcriptional Regulation by MECP2	0.009725878634518473	0.009725878634518473	+1	PTEN,SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.011050124468176624	0.011050124468176624	+1	SMAD4,SIN3A,SMAD2
REAC:R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.011050124468176624	0.011050124468176624	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-6804758	Regulation of TP53 Activity through Acetylation	0.011050124468176624	0.011050124468176624	+1	TP53,AKT1,EP300
REAC:R-HSA-9022692	Regulation of MECP2 expression and activity	0.011050124468176624	0.011050124468176624	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-1250342	PI3K events in ERBB4 signaling	0.01142738249231284	0.01142738249231284	+1	PIK3CA,PIK3R1
REAC:R-HSA-198203	PI3K/AKT activation	0.01142738249231284	0.01142738249231284	+1	PIK3CA,PIK3R1
REAC:R-HSA-6811555	PI5P Regulates TP53 Acetylation	0.01142738249231284	0.01142738249231284	+1	TP53,EP300
REAC:R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.01142738249231284	0.01142738249231284	+1	CTNNB1,CDH1
REAC:R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	0.01142738249231284	0.01142738249231284	+1	NRAS,PTPN11
REAC:R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.011824227224054846	0.011824227224054846	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.011824227224054846	0.011824227224054846	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-69481	G2/M Checkpoints	0.012302847682465081	0.012302847682465081	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-5693537	Resolution of D-Loop Structures	0.012808301469390524	0.012808301469390524	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-5655302	Signaling by FGFR1 in disease	0.012808301469390524	0.012808301469390524	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.013051054177009237	0.013051054177009237	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-5673000	RAF activation	0.013781665925966467	0.013781665925966467	+1	NRAS,BRAF,PPP2R1A
REAC:R-HSA-2172127	DAP12 interactions	0.013781665925966467	0.013781665925966467	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	0.013781665925966467	0.013781665925966467	+1	RUNX1,CBFB
REAC:R-HSA-392499	Metabolism of proteins	0.0138899698688547	0.0138899698688547	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,CTNNB1,DNMT3A,KEAP1,BAP1,NPM1,RPL22,STAG2,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,B4GALT3,SIN3A,HIST1H2BD,EIF4A2,SMC1A,SMC3,RPL5,SMAD2,AXIN2,RAD21
REAC:R-HSA-4791275	Signaling by WNT in cancer	0.014897126415874023	0.014897126415874023	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.01602027774105026	0.01602027774105026	+1	ATM,BRCA1,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-351906	Apoptotic cleavage of cell adhesion  proteins	0.016299862043152195	0.016299862043152195	+1	CTNNB1,CDH1
REAC:R-HSA-1433617	Regulation of signaling by NODAL	0.016299862043152195	0.016299862043152195	+1	ACVR1B,ACVR2A
REAC:R-HSA-179812	GRB2 events in EGFR signaling	0.016299862043152195	0.016299862043152195	+1	EGFR,NRAS
REAC:R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	0.017206202058851764	0.017206202058851764	+1	EP300,TBL1XR1,NCOR1
REAC:R-HSA-1980143	Signaling by NOTCH1	0.018067094390189053	0.018067094390189053	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.018326715543575678	0.018326715543575678	+1	ATM,BRCA1,ATR
REAC:R-HSA-212300	PRC2 methylates histones and DNA	0.018326715543575678	0.018326715543575678	+1	DNMT3A,HIST1H2BD,EZH2
REAC:R-HSA-111465	Apoptotic cleavage of cellular proteins	0.018326715543575678	0.018326715543575678	+1	APC,CTNNB1,CDH1
REAC:R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.01888778593387617	0.01888778593387617	+1	EGFR,KIT
REAC:R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.01888778593387617	0.01888778593387617	+1	TP53,ATM
REAC:R-HSA-180336	SHC1 events in EGFR signaling	0.01888778593387617	0.01888778593387617	+1	EGFR,NRAS
REAC:R-HSA-8853659	RET signaling	0.01941109063620992	0.01941109063620992	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-5689896	Ovarian tumor domain proteases	0.01941109063620992	0.01941109063620992	+1	TP53,PTEN,APC
REAC:R-HSA-9609646	HCMV Infection	0.021129604708263257	0.021129604708263257	+1	EGFR,HIST1H2BD,TBL1XR1,NCOR1,EZH2
REAC:R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	0.02172034525533453	0.02172034525533453	+1	ARHGAP35,NRAS
REAC:R-HSA-1963640	GRB2 events in ERBB2 signaling	0.02172034525533453	0.02172034525533453	+1	EGFR,NRAS
REAC:R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.02172034525533453	0.02172034525533453	+1	RB1,PPP2R1A
REAC:R-HSA-165159	MTOR signalling	0.02202615363838473	0.02202615363838473	+1	STK11,AKT1,MTOR
REAC:R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.02300415091606767	0.02300415091606767	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
REAC:R-HSA-3899300	SUMOylation of transcription cofactors	0.02343479857106601	0.02343479857106601	+1	NPM1,EP300,SIN3A
REAC:R-HSA-5693607	Processing of DNA double-strand break ends	0.023670405414667844	0.023670405414667844	+1	ATM,BRCA1,ATR,HIST1H2BD
REAC:R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.02410006551002555	0.02410006551002555	+1	APC,PPP2R1A
REAC:R-HSA-5654706	FRS-mediated FGFR3 signaling	0.02410006551002555	0.02410006551002555	+1	NRAS,PTPN11
REAC:R-HSA-4839735	Signaling by AXIN mutants	0.02410006551002555	0.02410006551002555	+1	APC,PPP2R1A
REAC:R-HSA-4839748	Signaling by AMER1 mutants	0.02410006551002555	0.02410006551002555	+1	APC,PPP2R1A
REAC:R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.02410006551002555	0.02410006551002555	+1	APC,PPP2R1A
REAC:R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.02410006551002555	0.02410006551002555	+1	APC,PPP2R1A
REAC:R-HSA-8941856	RUNX3 regulates NOTCH signaling	0.02410006551002555	0.02410006551002555	+1	NOTCH1,EP300
REAC:R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.02410006551002555	0.02410006551002555	+1	TP53,AKT1
REAC:R-HSA-4839744	Signaling by APC mutants	0.02410006551002555	0.02410006551002555	+1	APC,PPP2R1A
REAC:R-HSA-5675221	Negative regulation of MAPK pathway	0.0241535850100716	0.0241535850100716	+1	NRAS,BRAF,PPP2R1A
REAC:R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.0243227648558263	0.0243227648558263	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-168256	Immune System	0.024410271771720067	0.024410271771720067	+1	TP53,PIK3CA,PTEN,VHL,KRAS,EGFR,NF1,PIK3R1,GATA3,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,NRAS,IDH1,MAP2K4,AKT1,BRAF,HGF,MTOR,TLR4,KIT,PDGFRA,EP300,CCND1,CDKN1A,PPP2R1A,EIF4A2,PTPN11,LIFR
REAC:R-HSA-1500931	Cell-Cell communication	0.02496047934409365	0.02496047934409365	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,PTPN11
REAC:R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.02563502521462662	0.02563502521462662	+1	CEBPA,EP300,TBL1XR1,NCOR1
REAC:R-HSA-6802957	Oncogenic MAPK signaling	0.02563502521462662	0.02563502521462662	+1	KRAS,NF1,NRAS,BRAF
REAC:R-HSA-5628897	TP53 Regulates Metabolic Genes	0.025758407492530607	0.025758407492530607	+1	TP53,PTEN,AKT1,MTOR
REAC:R-HSA-1483255	PI Metabolism	0.025758407492530607	0.025758407492530607	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-6802949	Signaling by RAS mutants	0.025758407492530607	0.025758407492530607	+1	KRAS,NRAS,BRAF
REAC:R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	0.025758407492530607	0.025758407492530607	+1	EP300,TBL1XR1,NCOR1
REAC:R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.025758407492530607	0.025758407492530607	+1	KRAS,NRAS,BRAF
REAC:R-HSA-9649948	Signaling downstream of RAS mutants	0.025758407492530607	0.025758407492530607	+1	KRAS,NRAS,BRAF
REAC:R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.025758407492530607	0.025758407492530607	+1	KRAS,NRAS,BRAF
REAC:R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.02701681111999676	0.02701681111999676	+1	TLR4,PTPN11
REAC:R-HSA-9614657	FOXO-mediated transcription of cell death genes	0.02701681111999676	0.02701681111999676	+1	STK11,EP300
REAC:R-HSA-5654693	FRS-mediated FGFR1 signaling	0.02701681111999676	0.02701681111999676	+1	NRAS,PTPN11
REAC:R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.02701681111999676	0.02701681111999676	+1	TP53,RB1
REAC:R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.02701681111999676	0.02701681111999676	+1	NOTCH1,EP300
REAC:R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	0.02701681111999676	0.02701681111999676	+1	PIK3CA,PIK3R1
REAC:R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.02701681111999676	0.02701681111999676	+1	EGFR,NRAS
REAC:R-HSA-3371556	Cellular response to heat stress	0.027513235910346295	0.027513235910346295	+1	ATM,MTOR,EP300,ATR
REAC:R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.028280727899756653	0.028280727899756653	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-9012852	Signaling by NOTCH3	0.02986719625063725	0.02986719625063725	+1	EGFR,NOTCH1,EP300
REAC:R-HSA-432142	Platelet sensitization by LDL	0.030080847871381586	0.030080847871381586	+1	PPP2R1A,PTPN11
REAC:R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.03053389279209139	0.03053389279209139	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.03152250888837179	0.03152250888837179	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.03152250888837179	0.03152250888837179	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	0.032706853622205864	0.032706853622205864	+1	EGFR,NRAS
REAC:R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.032706853622205864	0.032706853622205864	+1	ATM,BRCA1,HIST1H2BD
REAC:R-HSA-5654712	FRS-mediated FGFR4 signaling	0.032706853622205864	0.032706853622205864	+1	NRAS,PTPN11
REAC:R-HSA-3232118	SUMOylation of transcription factors	0.032706853622205864	0.032706853622205864	+1	TP53,CDKN2A
REAC:R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.032706853622205864	0.032706853622205864	+1	TP53,EP300
REAC:R-HSA-1250196	SHC1 events in ERBB2 signaling	0.032706853622205864	0.032706853622205864	+1	EGFR,NRAS
REAC:R-HSA-1368082	RORA activates gene expression	0.032706853622205864	0.032706853622205864	+1	EP300,TBL1XR1
REAC:R-HSA-75153	Apoptotic execution phase	0.03405140372812202	0.03405140372812202	+1	APC,CTNNB1,CDH1
REAC:R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.03412296035890868	0.03412296035890868	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.03412296035890868	0.03412296035890868	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	0.03412296035890868	0.03412296035890868	+1	GATA3,RUNX1,CBFB,HIST1H2BD
REAC:R-HSA-5663205	Infectious disease	0.03512989299446578	0.03512989299446578	+1	VHL,EGFR,RB1,CTNNB1,CDH1,NPM1,MAP2K4,RPL22,TAF1,HIST1H2BD,TBL1XR1,NCOR1,RPL5,ERCC2,EZH2
REAC:R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.03516689263397664	0.03516689263397664	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-8876384	Listeria monocytogenes entry into host cells	0.03526256658325588	0.03526256658325588	+1	CTNNB1,CDH1
REAC:R-HSA-109606	Intrinsic Pathway for Apoptosis	0.03526256658325588	0.03526256658325588	+1	TP53,CDKN2A,AKT1
REAC:R-HSA-210745	Regulation of gene expression in beta cells	0.03526256658325588	0.03526256658325588	+1	AKT1,FOXA2
REAC:R-HSA-8978934	Metabolism of cofactors	0.03526256658325588	0.03526256658325588	+1	IDH1,AKT1
REAC:R-HSA-5654700	FRS-mediated FGFR2 signaling	0.03526256658325588	0.03526256658325588	+1	NRAS,PTPN11
REAC:R-HSA-166166	MyD88-independent TLR4 cascade 	0.0357506269977416	0.0357506269977416	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling 	0.0357506269977416	0.0357506269977416	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.03647351476839915	0.03647351476839915	+1	IDH2,TBL1XR1,NCOR1
REAC:R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.036719716844406565	0.036719716844406565	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.036719716844406565	0.036719716844406565	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-5250924	B-WICH complex positively regulates rRNA expression	0.037925375013181634	0.037925375013181634	+1	EP300,SF3B1,HIST1H2BD
REAC:R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	0.037925375013181634	0.037925375013181634	+1	NOTCH1,EP300
REAC:R-HSA-5621575	CD209 (DC-SIGN) signaling	0.037925375013181634	0.037925375013181634	+1	NRAS,EP300
REAC:R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.037925375013181634	0.037925375013181634	+1	TP53,ATM
REAC:R-HSA-8941858	Regulation of RUNX3 expression and activity	0.037925375013181634	0.037925375013181634	+1	CDKN2A,EP300,CBFB
REAC:R-HSA-3214815	HDACs deacetylate histones	0.03944104188067988	0.03944104188067988	+1	HIST1H2BD,TBL1XR1,NCOR1
REAC:R-HSA-168898	Toll-like Receptor Cascades	0.04041654800639073	0.04041654800639073	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.04122321236945542	0.04122321236945542	+1	TP53,NPM1
REAC:R-HSA-912631	Regulation of signaling by CBL	0.04122321236945542	0.04122321236945542	+1	PIK3CA,PIK3R1
REAC:R-HSA-113510	E2F mediated regulation of DNA replication	0.043933654014113956	0.043933654014113956	+1	RB1,PPP2R1A
REAC:R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.043933654014113956	0.043933654014113956	+1	SMAD4,SMAD2
REAC:R-HSA-373753	Nephrin family interactions	0.04769049953839256	0.04769049953839256	+1	PIK3CA,PIK3R1
REAC:R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	0.047804897142161434	0.047804897142161434	+1	CDKN1B,CCND1,CDKN1A
REAC:R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.04979851217588413	0.04979851217588413	+1	EP300,PPP2R1A,EGR3