GO.ID	Description	p.Val	FDR	Phenotype	Genes
HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20200810%WP4674%HOMO SAPIENS	Head and Neck Squamous Cell Carcinoma	1.0342701224811854e-29	1.0342701224811854e-29	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,PIK3R1,CDKN2A,RB1,NOTCH1,CTNNB1,KEAP1,NFE2L2,NRAS,STK11,AKT1,AJUBA,PIK3CG,MTOR,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A
SIGNALING PATHWAYS IN GLIOBLASTOMA%WIKIPATHWAYS_20200810%WP2261%HOMO SAPIENS	Signaling Pathways in Glioblastoma	1.2821952997268889e-28	1.2821952997268889e-28	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NRAS,MAP2K4,AKT1,BRAF,PIK3CG,ATM,CDKN1B,BRCA1,PDGFRA,EP300,FGFR2,CCND1,BRCA2,CDKN1A,CDKN2C
PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20200810%WP3651%HOMO SAPIENS	Pathways Affected in Adenoid Cystic Carcinoma	3.3056405724664594e-22	3.3056405724664594e-22	+1	TP53,PIK3CA,PTEN,ARID1A,NOTCH1,FBXW7,CEBPA,KDM6A,AKT1,ATM,ARID5B,ATRX,BRCA1,CHEK2,SETD2,EP300,SMC1A,NSD1,NCOR1
INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20200810%WP1984%HOMO SAPIENS	Integrated Breast Cancer Pathway	2.0484533041887747e-20	2.0484533041887747e-20	+1	TP53,PTEN,KRAS,EGFR,NF1,RB1,CTNNB1,CDH1,STK11,AKT1,BRAF,AR,ATM,MTOR,BRCA1,CHEK2,EP300,CCND1,SMAD4,BRCA2,TGFBR2,ATR,SMAD2
ENDOMETRIAL CANCER%WIKIPATHWAYS_20200810%WP4155%HOMO SAPIENS	Endometrial cancer	2.6876464750363393e-19	2.6876464750363393e-19	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,PIK3R1,CTNNB1,CDH1,NRAS,AKT1,BRAF,FGFR2,CCND1,FGFR3,CDKN1A,AXIN2
BREAST CANCER PATHWAY%WIKIPATHWAYS_20200810%WP4262%HOMO SAPIENS	Breast cancer pathway	5.00633039438871e-19	5.00633039438871e-19	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,PIK3R1,RB1,NOTCH1,CTNNB1,NRAS,AKT1,BRAF,ATM,MTOR,BRCA1,KIT,CCND1,BRCA2,CDKN1A,ATR,AXIN2
MELANOMA%WIKIPATHWAYS_20200810%WP4685%HOMO SAPIENS	Melanoma	4.008817978766855e-17	4.008817978766855e-17	+1	TP53,PIK3CA,PTEN,KRAS,NF1,PIK3R1,CDKN2A,RB1,CDH1,NRAS,AKT1,BRAF,ERBB4,KIT,CCND1,CDKN1A
P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398	p53 pathway feedback loops 2	2.8208630584681916e-15	2.8208630584681916e-15	+1	TP53,PIK3CA,PTEN,KRAS,PIK3R1,RB1,CTNNB1,NRAS,AKT1,PIK3CG,ATM,CDKN1A,ATR
PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20200810%WP4263%HOMO SAPIENS	Pancreatic adenocarcinoma pathway	2.8208630584681916e-15	2.8208630584681916e-15	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CDKN2A,RB1,AKT1,BRAF,MTOR,CCND1,SMAD4,BRCA2,TGFBR2,CDKN1A,SMAD2
DNA DAMAGE RESPONSE (ONLY ATM DEPENDENT)%WIKIPATHWAYS_20200810%WP710%HOMO SAPIENS	DNA Damage Response (only ATM dependent)	7.158196221581645e-15	7.158196221581645e-15	+1	TP53,PIK3CA,PTEN,APC,KRAS,PIK3R1,CDKN2A,CTNNB1,MAP3K1,NRAS,AKT1,PIK3CG,ATM,CDKN1B,CCND1,SMAD4,CDKN1A
TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR	TGF_beta_Receptor	9.73851514764066e-15	9.73851514764066e-15	+1	TP53,PIK3CA,PIK3R1,RB1,CTNNB1,CTCF,RUNX1,STK11,AKT1,AR,SOX9,MTOR,BRCA1,EP300,CCND1,SMAD4,TGFBR2,CDKN1A,PPP2R1A,SMAD2,AXIN2
CELL CYCLE%WIKIPATHWAYS_20200810%WP179%HOMO SAPIENS	Cell Cycle	1.9589332904015506e-14	1.9589332904015506e-14	+1	TP53,CDKN2A,RB1,STAG2,ATM,CDKN1B,CHEK2,EP300,CCND1,SMAD4,CDKN1A,ATR,SMC1A,SMC3,SMAD2,RAD21,CDKN2C
EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20200810%WP4806%HOMO SAPIENS	EGFR Tyrosine Kinase Inhibitor Resistance	2.891308383559845e-14	2.891308383559845e-14	+1	PIK3CA,PTEN,KRAS,EGFR,NF1,PIK3R1,NRAS,AKT1,BRAF,HGF,MTOR,PDGFRA,FGFR2,CCND1,FGFR3
EXTRACELLULAR VESICLE-MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20200810%WP2870%HOMO SAPIENS	Extracellular vesicle-mediated signaling in recipient cells	5.5845539817568114e-14	5.5845539817568114e-14	+1	APC,KRAS,EGFR,CTNNB1,NRAS,AKT1,HGF,MTOR,SMAD4,TGFBR2,SMAD2
BLADDER CANCER%WIKIPATHWAYS_20200810%WP2828%HOMO SAPIENS	Bladder Cancer	5.5845539817568114e-14	5.5845539817568114e-14	+1	TP53,KRAS,EGFR,PIK3R1,CDKN2A,RB1,CDH1,NRAS,BRAF,CCND1,FGFR3,CDKN1A
BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY	BIOCARTA_CTCF_PATHWAY	1.6134035774953343e-13	1.6134035774953343e-13	+1	TP53,PIK3CA,PTEN,PIK3R1,CDKN2A,PIK3CG,CDKN1B,MTOR,SMAD4,TGFBR2
ANDROGEN RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP138%HOMO SAPIENS	Androgen receptor signaling pathway	1.7089749745470005e-12	1.7089749745470005e-12	+1	PTEN,EGFR,PIK3R1,RB1,CTNNB1,AKT1,AR,BRCA1,EP300,CCND1,SMAD4,CDKN1A,SIN3A,NCOR1
ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR	AndrogenReceptor	1.7089749745470005e-12	1.7089749745470005e-12	+1	PTEN,EGFR,PIK3R1,RB1,CTNNB1,RUNX1,CEBPA,AKT1,AR,BRCA1,FOXA1,EP300,CCND1,SMAD4,SIN3A,NSD1
ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP673%HOMO SAPIENS	ErbB Signaling Pathway	1.7089749745470005e-12	1.7089749745470005e-12	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,NRAS,MAP2K4,AKT1,BRAF,CDKN1B,ERBB4,MTOR,CCND1,CDKN1A
PROTEIN AUTOPHOSPHORYLATION%GOBP%GO:0046777	protein autophosphorylation	2.8208300018679792e-12	2.8208300018679792e-12	+1	EGFR,FLT3,STK11,AKT1,ATM,ERBB4,MTOR,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,FGFR3,TAF1,ATR,CDK12,ACVR1B
REGULATION OF CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:1902806	regulation of cell cycle G1/S phase transition	4.820927461567418e-12	4.820927461567418e-12	+1	TP53,PTEN,EGFR,CDKN2A,RB1,FBXW7,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,TAF1,CDKN2C,EZH2
P53 PATHWAY%PANTHER PATHWAY%P00059	p53 pathway	6.423838465296025e-12	6.423838465296025e-12	+1	TP53,PIK3CA,PTEN,CDKN2A,AKT1,ATM,CHEK2,EP300,CDKN1A,ATR,SIN3A
INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20200810%WP1971%HOMO SAPIENS	Integrated Cancer Pathway	8.023847406054564e-12	8.023847406054564e-12	+1	TP53,PTEN,RB1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CDKN1A,ATR,SMAD2
REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0010717	regulation of epithelial to mesenchymal transition	1.1838615915567024e-11	1.1838615915567024e-11	+1	PTEN,GATA3,NOTCH1,CTNNB1,EPHA3,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR	TGF_beta_Receptor	1.9183024629213366e-11	1.9183024629213366e-11	+1	TP53,PIK3R1,RB1,CTNNB1,CTCF,STK11,AKT1,AR,SOX9,BRCA1,EP300,CCND1,SMAD4,TGFBR2,CDKN1A,SMAD2,AXIN2
GASTRIN SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP4659%HOMO SAPIENS	Gastrin Signaling Pathway	3.6701124368877526e-11	3.6701124368877526e-11	+1	PIK3CA,KRAS,EGFR,PIK3R1,CDKN2A,CTNNB1,CDH1,AKT1,CDKN1B,MTOR,KIT,CCND1,CDKN1A,PTPN11
NON-SMALL CELL LUNG CANCER%WIKIPATHWAYS_20200810%WP4255%HOMO SAPIENS	Non-small cell lung cancer	4.693513401939261e-11	4.693513401939261e-11	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CDKN2A,RB1,NRAS,AKT1,BRAF,CCND1,CDKN1A
CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20200810%WP4216%HOMO SAPIENS	Chromosomal and microsatellite instability in colorectal cancer	7.288535701532106e-11	7.288535701532106e-11	+1	TP53,APC,KRAS,CTNNB1,AKT1,BRAF,CCND1,SMAD4,TGFBR2,CDKN1A,SMAD2,AXIN2
BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY	BIOCARTA_G1_PATHWAY	7.288535701532106e-11	7.288535701532106e-11	+1	TP53,CDKN2A,RB1,ATM,CDKN1B,CCND1,SMAD4,CDKN1A,ATR
ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.2	ESR-mediated signaling	1.1177546135110856e-10	1.1177546135110856e-10	+1	PIK3CA,EGFR,PIK3R1,GATA3,RUNX1,NRAS,AKT1,STAG2,CDKN1B,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20200810%WP2857%HOMO SAPIENS	Mesodermal Commitment Pathway	1.2482718963470773e-10	1.2482718963470773e-10	+1	GATA3,NFE2L2,TBX3,KDM6A,ARID5B,FOXA1,SETD2,CCND1,SMAD4,FOXA2,SOX17,PHF6,ACVR2A,SMAD2,AXIN2
HEPATITIS B INFECTION%WIKIPATHWAYS_20200810%WP4666%HOMO SAPIENS	Hepatitis B infection	1.2482718963470773e-10	1.2482718963470773e-10	+1	PIK3CA,KRAS,PIK3R1,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,TLR4,EP300,SMAD4,TGFBR2,CDKN1A,EGR3,SMAD2
PI3K-AKT-MTOR SIGNALING PATHWAY AND THERAPEUTIC OPPORTUNITIES%WIKIPATHWAYS_20200810%WP3844%HOMO SAPIENS	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities	1.3037388957603046e-10	1.3037388957603046e-10	+1	PIK3CA,PTEN,KRAS,PIK3R1,NRAS,AKT1,PIK3CG,CDKN1B,MTOR
NEGATIVE REGULATION OF TRANSFERASE ACTIVITY%GOBP%GO:0051348	negative regulation of transferase activity	1.787114356940053e-10	1.787114356940053e-10	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,EIF4A2,MAPK8IP1,RPL5
PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY	PID_CMYB_PATHWAY	2.396702920060849e-10	2.396702920060849e-10	+1	KRAS,CDKN2A,GATA3,NRAS,CEBPA,CDKN1B,KIT,EP300,CCND1,CDKN1A,SIN3A,NCOR1
C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK	C-MYB transcription factor network	2.396702920060849e-10	2.396702920060849e-10	+1	KRAS,CDKN2A,GATA3,NRAS,CEBPA,CDKN1B,KIT,EP300,CCND1,CDKN1A,SIN3A,NCOR1
PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.1	PI3K AKT Signaling in Cancer	4.743931789460931e-10	4.743931789460931e-10	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PTPN11
NEGATIVE REGULATION OF GROWTH%GOBP%GO:0045926	negative regulation of growth	5.775100344548353e-10	5.775100344548353e-10	+1	TP53,PTEN,CDKN2A,RB1,NOTCH1,STK11,CDKN1B,WT1,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
ESC PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20200810%WP3931%HOMO SAPIENS	ESC Pluripotency Pathways	7.65464957227083e-10	7.65464957227083e-10	+1	PTEN,APC,EGFR,CTNNB1,AKT1,BRAF,MTOR,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11,LIFR
MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20200810%WP3584%HOMO SAPIENS	MECP2 and Associated Rett Syndrome	1.0342242437232256e-9	1.0342242437232256e-9	+1	PTEN,NF1,CTCF,AKT1,MTOR,TET2,TAF1,SIN3A,SMC3,NCOR1,EZH2
REGULATION OF G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:2000045	regulation of G1/S transition of mitotic cell cycle	2.296234780472316e-9	2.296234780472316e-9	+1	TP53,PTEN,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	2.4065620259147747e-9	2.4065620259147747e-9	+1	PIK3CA,APC,PIK3R1,CTNNB1,MAP3K1,CDH1,MAP2K4,AKT1,HGF,MTOR,PTPN11
PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY	PID_MET_PATHWAY	2.7078277911980483e-9	2.7078277911980483e-9	+1	PIK3CA,APC,PIK3R1,CTNNB1,MAP3K1,CDH1,MAP2K4,AKT1,HGF,MTOR,PTPN11
PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY	PID_SMAD2_3NUCLEAR_PATHWAY	3.0424679916371105e-9	3.0424679916371105e-9	+1	GATA3,RUNX1,AKT1,AR,EP300,SMAD4,CDKN1A,CBFB,SIN3A,NCOR1,SMAD2
REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING	Regulation of nuclear SMAD2 3 signaling	3.413688360195036e-9	3.413688360195036e-9	+1	GATA3,RUNX1,AKT1,AR,EP300,SMAD4,CDKN1A,CBFB,SIN3A,NCOR1,SMAD2
PATHWAYS IN CLEAR CELL RENAL CELL CARCINOMA%WIKIPATHWAYS_20200810%WP4018%HOMO SAPIENS	Pathways in clear cell renal cell carcinoma	5.6860857217692385e-9	5.6860857217692385e-9	+1	PTEN,VHL,PBRM1,EGFR,BAP1,AKT1,KDM5C,MTOR,SETD2,PDGFRA,EP300
PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 73%1257604	PI3K AKT Signaling	7.74997433788732e-9	7.74997433788732e-9	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PPP2R1A,PTPN11,MECOM,EZH2
ARYL HYDROCARBON RECEPTOR NETPATH%WIKIPATHWAYS_20200810%WP2586%HOMO SAPIENS	Aryl Hydrocarbon Receptor Netpath	9.357802456382596e-9	9.357802456382596e-9	+1	KRAS,EGFR,NF1,RB1,NFE2L2,NRAS,CDKN1B,EP300,CDKN1A
NEGATIVE REGULATION OF G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	1.2715120013032327e-8	1.2715120013032327e-8	+1	TP53,PTEN,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
DNA DAMAGE RESPONSE%WIKIPATHWAYS_20200810%WP707%HOMO SAPIENS	DNA Damage Response	1.322509772686152e-8	1.322509772686152e-8	+1	TP53,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR,SMC1A
PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY	PID_ECADHERIN_KERATINOCYTE_PATHWAY	1.3290157570215978e-8	1.3290157570215978e-8	+1	PIK3CA,EGFR,PIK3R1,CTNNB1,CDH1,AKT1,AJUBA
E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES	E-cadherin signaling in keratinocytes	1.3290157570215978e-8	1.3290157570215978e-8	+1	PIK3CA,EGFR,PIK3R1,CTNNB1,CDH1,AKT1,AJUBA
HIPPO-MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20200810%WP4541%HOMO SAPIENS	Hippo-Merlin Signaling Dysregulation	1.3290157570215978e-8	1.3290157570215978e-8	+1	KRAS,EGFR,CTNNB1,FLT3,CDH1,NRAS,AJUBA,KIT,PDGFRA,FGFR2,CCND1,FGFR3
PHOTODYNAMIC THERAPY-INDUCED AP-1 SURVIVAL SIGNALING.%WIKIPATHWAYS_20200810%WP3611%HOMO SAPIENS	Photodynamic therapy-induced AP-1 survival signaling.	1.4272109240974268e-8	1.4272109240974268e-8	+1	TP53,EGFR,CDKN2A,RB1,NFE2L2,MAP2K4,PDGFRA,CCND1,CDKN1A
NEGATIVE REGULATION OF CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:1902807	negative regulation of cell cycle G1/S phase transition	1.4272109240974268e-8	1.4272109240974268e-8	+1	TP53,PTEN,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-HSA-8878159.2	Transcriptional regulation by RUNX3	1.4272109240974268e-8	1.4272109240974268e-8	+1	TP53,KRAS,CDKN2A,NOTCH1,CTNNB1,RUNX1,EP300,CCND1,SMAD4,CDKN1A,CBFB
ANGIOGENESIS%PANTHER PATHWAY%P00005	Angiogenesis	1.5619089723150042e-8	1.5619089723150042e-8	+1	PIK3CA,APC,PIK3R1,NOTCH1,CTNNB1,MAP3K1,NRAS,MAP2K4,EPHA3,AKT1,BRAF,PIK3CG,PDGFRA
MIRNA REGULATION OF PROSTATE CANCER SIGNALING PATHWAYS%WIKIPATHWAYS_20200810%WP3981%HOMO SAPIENS	miRNA regulation of prostate cancer signaling pathways	1.655728488767993e-8	1.655728488767993e-8	+1	TP53,PIK3CA,KRAS,CTNNB1,AR,CDKN1B,MTOR,CCND1,CDKN1A
DNA IR-DOUBLE STRAND BREAKS (DSBS) AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20200810%WP3959%HOMO SAPIENS	DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM	2.759260347256556e-8	2.759260347256556e-8	+1	TP53,CDKN2A,ATM,BRCA1,CHEK2,BRCA2,ATR,SMC1A,SMC3
EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20200810%WP4239%HOMO SAPIENS	Epithelial to mesenchymal transition in colorectal cancer	2.7884443009245648e-8	2.7884443009245648e-8	+1	TP53,PIK3CA,KRAS,PIK3R1,NOTCH1,CTNNB1,CDH1,MAP2K4,AKT1,SMAD4,TGFBR2,SMAD2,EZH2
NEGATIVE REGULATION OF KINASE ACTIVITY%GOBP%GO:0033673	negative regulation of kinase activity	2.7884443009245648e-8	2.7884443009245648e-8	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1
REGULATION OF PROTEIN KINASE B SIGNALING%GOBP%GO:0051896	regulation of protein kinase B signaling	2.9333560477128675e-8	2.9333560477128675e-8	+1	PIK3CA,PTEN,EGFR,PIK3R1,GATA3,AKT1,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY	BIOCARTA_G2_PATHWAY	3.251933014196301e-8	3.251933014196301e-8	+1	TP53,ATM,BRCA1,CHEK2,EP300,CDKN1A,ATR
ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING	ErbB1 downstream signaling	3.318038209016273e-8	3.318038209016273e-8	+1	PIK3CA,KRAS,EGFR,PIK3R1,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,MTOR,PPP2R1A
PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY	PID_ERBB1_DOWNSTREAM_PATHWAY	3.6258592574937096e-8	3.6258592574937096e-8	+1	PIK3CA,KRAS,EGFR,PIK3R1,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,MTOR,PPP2R1A
MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20200810%WP4205%HOMO SAPIENS	MET in type 1 papillary renal cell carcinoma	4.052051779076567e-8	4.052051779076567e-8	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,BRAF,HGF,CDKN1A,PTPN11
SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 73%3108232	SUMO E3 ligases SUMOylate target proteins	4.173756992426315e-8	4.173756992426315e-8	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
RELATIONSHIP BETWEEN INFLAMMATION, COX-2 AND EGFR%WIKIPATHWAYS_20200810%WP4483%HOMO SAPIENS	Relationship between inflammation, COX-2 and EGFR	4.173756992426315e-8	4.173756992426315e-8	+1	PIK3CA,KRAS,EGFR,NRAS,AKT1,BRAF,PIK3CG
POSITIVE REGULATION OF CELL CYCLE PROCESS%GOBP%GO:0090068	positive regulation of cell cycle process	5.012771714886886e-8	5.012771714886886e-8	+1	TP53,EGFR,RB1,NPM1,AKT1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,RAD21,EZH2
NEGATIVE REGULATION OF CELL GROWTH%GOBP%GO:0030308	negative regulation of cell growth	5.102339177921491e-8	5.102339177921491e-8	+1	TP53,CDKN2A,RB1,STK11,CDKN1B,WT1,SMAD4,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY	BIOCARTA_RACCYCD_PATHWAY	5.4148070056404e-8	5.4148070056404e-8	+1	PIK3CA,PIK3R1,RB1,AKT1,CDKN1B,CCND1,CDKN1A
REGULATION OF CYCLIN-DEPENDENT PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	5.840679660486074e-8	5.840679660486074e-8	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
SUMOYLATION%REACTOME DATABASE ID RELEASE 73%2990846	SUMOylation	5.986349738219585e-8	5.986349738219585e-8	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
NOTCH SIGNALING PATHWAY NETPATH%WIKIPATHWAYS_20200810%WP61%HOMO SAPIENS	Notch Signaling Pathway Netpath	6.70992553645446e-8	6.70992553645446e-8	+1	PIK3R1,GATA3,NOTCH1,FBXW7,AKT1,EP300,CCND1,CDKN1A,NCOR1
CELL CYCLE ARREST%GOBP%GO:0007050	cell cycle arrest	6.872651354535973e-8	6.872651354535973e-8	+1	TP53,APC,CDKN2A,RB1,NOTCH1,STK11,ATM,CDKN1B,MTOR,CDKN1A,CDKN2C
BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY	BIOCARTA_GSK3_PATHWAY	6.872651354535973e-8	6.872651354535973e-8	+1	PIK3CA,APC,PIK3R1,CTNNB1,AKT1,TLR4,CCND1
POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0010718	positive regulation of epithelial to mesenchymal transition	7.201991434372458e-8	7.201991434372458e-8	+1	NOTCH1,CTNNB1,MTOR,SMAD4,TGFBR2,SMAD2,AXIN2,EZH2
VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION	Validated targets of C-MYC transcriptional repression	7.285770181356385e-8	7.285770181356385e-8	+1	DNMT3A,CEBPA,CDKN1B,BRCA1,EP300,CCND1,SMAD4,CDKN1A,SMAD2
PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY	PID_MYC_REPRESS_PATHWAY	7.285770181356385e-8	7.285770181356385e-8	+1	DNMT3A,CEBPA,CDKN1B,BRCA1,EP300,CCND1,SMAD4,CDKN1A,SMAD2
REGULATION OF CYCLIN-DEPENDENT PROTEIN KINASE ACTIVITY%GOBP%GO:1904029	regulation of cyclin-dependent protein kinase activity	8.374746215848415e-8	8.374746215848415e-8	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20200810%WP51%HOMO SAPIENS	Regulation of Actin Cytoskeleton	9.688559281180966e-8	9.688559281180966e-8	+1	PIK3CA,APC,KRAS,EGFR,PIK3R1,ARHGAP35,NRAS,BRAF,PIK3CG,PDGFRA,FGFR2,FGFR3
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS%MSIGDB_C2%ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	9.688559281180966e-8	9.688559281180966e-8	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,BRAF,PTPN11,MAPK8IP1,EGR3
NEGATIVE REGULATION OF PROTEIN KINASE ACTIVITY%GOBP%GO:0006469	negative regulation of protein kinase activity	9.688559281180966e-8	9.688559281180966e-8	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,CDKN1A,PPP2R1A,MAPK8IP1
RAS SIGNALING%WIKIPATHWAYS_20200810%WP4223%HOMO SAPIENS	Ras Signaling	9.688559281180966e-8	9.688559281180966e-8	+1	PIK3CA,KRAS,EGFR,NF1,PIK3R1,FLT3,NRAS,AKT1,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20200810%WP1530%HOMO SAPIENS	miRNA Regulation of DNA Damage Response	9.861919690552481e-8	9.861919690552481e-8	+1	TP53,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR,SMC1A
POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING%GOBP%GO:0051897	positive regulation of protein kinase B signaling	1.0806195590614202e-7	1.0806195590614202e-7	+1	PIK3CA,EGFR,PIK3R1,GATA3,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
CELL AGING%GOBP%GO:0007569	cell aging	1.1251506507867869e-7	1.1251506507867869e-7	+1	TP53,CDKN2A,NPM1,TBX3,ATM,CHEK2,CDKN1A,ATR
BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY	BIOCARTA_ARF_PATHWAY	1.1691545602861579e-7	1.1691545602861579e-7	+1	TP53,PIK3CA,PIK3R1,CDKN2A,RB1,PIK3CG
BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY	BIOCARTA_HCMV_PATHWAY	1.1691545602861579e-7	1.1691545602861579e-7	+1	PIK3CA,PIK3R1,RB1,MAP3K1,AKT1,PIK3CG
ASSOCIATION BETWEEN PHYSICO-CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20200810%WP3680%HOMO SAPIENS	Association Between Physico-Chemical Features and Toxicity Associated Pathways	1.2752894485442147e-7	1.2752894485442147e-7	+1	APC,EGFR,CTNNB1,MAP2K4,AKT1,PIK3CG,CDKN1B,ERBB4,CDKN1A
ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN	Alpha6Beta4Integrin	1.2752894485442147e-7	1.2752894485442147e-7	+1	PIK3CA,EGFR,PIK3R1,AKT1,AR,PIK3CG,MTOR,PTPN11,SMAD2
RAC1/PAK1/P38/MMP2 PATHWAY%WIKIPATHWAYS_20200810%WP3303%HOMO SAPIENS	RAC1/PAK1/p38/MMP2 Pathway	1.4413408726225557e-7	1.4413408726225557e-7	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CTNNB1,NRAS,AKT1,PTPN11
PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY	PID_CDC42_PATHWAY	1.591496510771063e-7	1.591496510771063e-7	+1	PIK3CA,APC,PIK3R1,CTNNB1,MAP3K1,CDH1,MAP2K4,BRAF,MTOR
RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 73%8951936	RUNX3 regulates p14-ARF	1.591496510771063e-7	1.591496510771063e-7	+1	KRAS,RUNX1,EP300,CCND1,CBFB
CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS	CDC42 signaling events	1.591496510771063e-7	1.591496510771063e-7	+1	PIK3CA,APC,PIK3R1,CTNNB1,MAP3K1,CDH1,MAP2K4,BRAF,MTOR
PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY	PDGFR-beta signaling pathway	1.606208516926395e-7	1.606208516926395e-7	+1	PIK3CA,PTEN,KRAS,PIK3R1,ARHGAP35,NRAS,MAP2K4,BRAF,PIK3CG,PPP2R1A,PTPN11
NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.3	Negative regulation of the PI3K AKT network	1.6393805363361712e-7	1.6393805363361712e-7	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
GLAND DEVELOPMENT%GOBP%GO:0048732	gland development	1.863233831542627e-7	1.863233831542627e-7	+1	NF1,ARHGAP35,TBX3,CEBPA,AKT1,SOX9,WT1,ERBB4,ARID5B,ELF3,FGFR2
REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 73%5633007	Regulation of TP53 Activity	1.9550688261075067e-7	1.9550688261075067e-7	+1	TP53,CDKN2A,STK11,AKT1,ATM,MTOR,BRCA1,CHEK2,EP300,TAF1,PPP2R1A,ATR
SYNAPTIC SIGNALING PATHWAYS ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20200810%WP4539%HOMO SAPIENS	Synaptic signaling pathways associated with autism spectrum disorder	1.9631203138169485e-7	1.9631203138169485e-7	+1	PIK3CA,PTEN,KRAS,NF1,PIK3R1,NRAS,AKT1,MTOR
RESPONSE TO UV%GOBP%GO:0009411	response to UV	1.9651561055849948e-7	1.9651561055849948e-7	+1	TP53,EGFR,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
PATHWAYS REGULATING HIPPO SIGNALING%WIKIPATHWAYS_20200810%WP4540%HOMO SAPIENS	Pathways Regulating Hippo Signaling	2.0930989805741252e-7	2.0930989805741252e-7	+1	EGFR,CTNNB1,FLT3,CDH1,MTOR,KIT,PDGFRA,FGFR2,FGFR3,SMAD2
PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY	PID_PDGFRB_PATHWAY	2.0930989805741252e-7	2.0930989805741252e-7	+1	PIK3CA,PTEN,KRAS,PIK3R1,ARHGAP35,NRAS,MAP2K4,BRAF,PIK3CG,PPP2R1A,PTPN11
HALLMARK_E2F_TARGETS%MSIGDB_C2%HALLMARK_E2F_TARGETS	HALLMARK_E2F_TARGETS	2.1251765216187936e-7	2.1251765216187936e-7	+1	TP53,CDKN2A,CTCF,CDKN1B,BRCA1,CHEK2,BRCA2,CDKN1A,SMC1A,SMC3,RAD21,CDKN2C,EZH2
E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK	E2F transcription factor network	2.1251765216187936e-7	2.1251765216187936e-7	+1	CDKN2A,RB1,CEBPA,ATM,CDKN1B,BRCA1,EP300,CDKN1A,CDKN2C
BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY	BIOCARTA_TGFB_PATHWAY	2.1251765216187936e-7	2.1251765216187936e-7	+1	APC,CDH1,EP300,SMAD4,TGFBR2,SMAD2
ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN	Alpha6Beta4Integrin	2.3187394811991382e-7	2.3187394811991382e-7	+1	PIK3CA,EGFR,PIK3R1,AKT1,AR,PIK3CG,MTOR,PTPN11,SMAD2
PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY	PID_E2F_PATHWAY	2.3187394811991382e-7	2.3187394811991382e-7	+1	CDKN2A,RB1,CEBPA,ATM,CDKN1B,BRCA1,EP300,CDKN1A,CDKN2C
REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE SIGNALING%GOBP%GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	2.6504875548956656e-7	2.6504875548956656e-7	+1	PIK3CA,PTEN,EGFR,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
TGF-BETA SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP366%HOMO SAPIENS	TGF-beta Signaling Pathway	2.691960578513625e-7	2.691960578513625e-7	+1	TP53,PIK3R1,MAP2K4,AKT1,EP300,CCND1,SMAD4,TGFBR2,CDKN1A,SIN3A,SMAD2
PHOSPHATIDYLINOSITOL 3-KINASE SIGNALING%GOBP%GO:0014065	phosphatidylinositol 3-kinase signaling	2.691960578513625e-7	2.691960578513625e-7	+1	PIK3CA,PTEN,NF1,PIK3R1,GATA3,AKT1,PIK3CG
MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP382%HOMO SAPIENS	MAPK Signaling Pathway	3.0358814704787127e-7	3.0358814704787127e-7	+1	TP53,KRAS,EGFR,NF1,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,LRRK2,FGFR2,FGFR3,TGFBR2,MAPK8IP1
NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION%GOBP%GO:1901988	negative regulation of cell cycle phase transition	3.5710234523357375e-7	3.5710234523357375e-7	+1	TP53,PTEN,APC,CDKN2A,RB1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY	BIOCARTA_TFF_PATHWAY	3.7703975260178456e-7	3.7703975260178456e-7	+1	PIK3CA,EGFR,PIK3R1,CTNNB1,AKT1,PIK3CG
PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY	PID_FGF_PATHWAY	3.7703975260178456e-7	3.7703975260178456e-7	+1	PIK3CA,PIK3R1,CDH1,AKT1,HGF,FGFR2,FGFR3,PTPN11
BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY	BIOCARTA_ATRBRCA_PATHWAY	3.7703975260178456e-7	3.7703975260178456e-7	+1	TP53,ATM,BRCA1,CHEK2,BRCA2,ATR
HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA/BETA COMPLEX%WIKIPATHWAYS_20200810%WP3657%HOMO SAPIENS	Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex	3.7703975260178456e-7	3.7703975260178456e-7	+1	PTEN,DNMT3A,FLT3,ATM,EP300,SMAD4
REGULATION OF SISTER CHROMATID COHESION%GOBP%GO:0007063	regulation of sister chromatid cohesion	3.7703975260178456e-7	3.7703975260178456e-7	+1	RB1,CTNNB1,CTCF,ATRX,AXIN2,RAD21
ST_ADRENERGIC%MSIGDB_C2%ST_ADRENERGIC	ST_ADRENERGIC	3.783514163047835e-7	3.783514163047835e-7	+1	PIK3CA,APC,EGFR,PIK3R1,AKT1,BRAF,AR
REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.1	Regulation of TP53 Degradation	3.783514163047835e-7	3.783514163047835e-7	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
AGING%GOBP%GO:0007568	aging	3.783514163047835e-7	3.783514163047835e-7	+1	TP53,CDKN2A,NPM1,TBX3,ATM,LRRK2,CHEK2,CDKN1A,ATR
PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY	PID_BETA_CATENIN_NUC_PATHWAY	4.0769836527748665e-7	4.0769836527748665e-7	+1	APC,CDKN2A,CTNNB1,CDH1,AR,EP300,CCND1,TBL1XR1,AXIN2
NEGATIVE REGULATION OF PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0071901	negative regulation of protein serine/threonine kinase activity	4.0769836527748665e-7	4.0769836527748665e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,CEBPA,AKT1,CDKN1B,PPP2R1A,MAPK8IP1
REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION	Regulation of nuclear beta catenin signaling and target gene transcription	4.0769836527748665e-7	4.0769836527748665e-7	+1	APC,CDKN2A,CTNNB1,CDH1,AR,EP300,CCND1,TBL1XR1,AXIN2
REPLICATIVE SENESCENCE%GOBP%GO:0090399	replicative senescence	4.34560330834304e-7	4.34560330834304e-7	+1	TP53,CDKN2A,ATM,CHEK2,ATR
REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME DATABASE ID RELEASE 73%6806003	Regulation of TP53 Expression and Degradation	4.452748122393625e-7	4.452748122393625e-7	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
NEGATIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN KINASE ACTIVITY%GOBP%GO:1904030	negative regulation of cyclin-dependent protein kinase activity	4.749318942950877e-7	4.749318942950877e-7	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B,CDKN1A
BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY	BIOCARTA_HER2_PATHWAY	4.749318942950877e-7	4.749318942950877e-7	+1	PIK3CA,EGFR,PIK3R1,PIK3CG,ERBB4,EP300
P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY	p53 pathway	5.887708554865678e-7	5.887708554865678e-7	+1	TP53,CDKN2A,AKT1,ATM,CHEK2,EP300,ATR,RPL5
PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY	PID_P53_REGULATION_PATHWAY	5.887708554865678e-7	5.887708554865678e-7	+1	TP53,CDKN2A,AKT1,ATM,CHEK2,EP300,ATR,RPL5
BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY	BIOCARTA_GLEEVEC_PATHWAY	6.099371599153256e-7	6.099371599153256e-7	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG
BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY	BIOCARTA_P53HYPOXIA_PATHWAY	6.099371599153256e-7	6.099371599153256e-7	+1	TP53,AKT1,ATM,EP300,CDKN1A,TAF1
BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY	BIOCARTA_CELLCYCLE_PATHWAY	6.099371599153256e-7	6.099371599153256e-7	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,CDKN2C
BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY	BIOCARTA_MTOR_PATHWAY	6.099371599153256e-7	6.099371599153256e-7	+1	PIK3CA,PTEN,PIK3R1,AKT1,MTOR,EIF4A2
CELLULAR RESPONSE TO ENVIRONMENTAL STIMULUS%GOBP%GO:0104004	cellular response to environmental stimulus	6.729118050887234e-7	6.729118050887234e-7	+1	TP53,PTEN,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 73%9018519	Estrogen-dependent gene expression	6.729118050887234e-7	6.729118050887234e-7	+1	GATA3,RUNX1,STAG2,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
CELLULAR RESPONSE TO ABIOTIC STIMULUS%GOBP%GO:0071214	cellular response to abiotic stimulus	6.729118050887234e-7	6.729118050887234e-7	+1	TP53,PTEN,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY	PID_IFNG_PATHWAY	7.222962863283093e-7	7.222962863283093e-7	+1	PIK3CA,PIK3R1,MAP3K1,AKT1,MTOR,EP300,PTPN11
BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY	BIOCARTA_EIF4_PATHWAY	7.790829734188764e-7	7.790829734188764e-7	+1	PIK3CA,PTEN,PIK3R1,AKT1,MTOR,EIF4A2
REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING%GOBP%GO:2000677	regulation of transcription regulatory region DNA binding	8.470680479712415e-7	8.470680479712415e-7	+1	GATA3,RB1,CTNNB1,EP300,TAF1,SIN3A,NSD1
ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS	ErbB2 ErbB3 signaling events	8.470680479712415e-7	8.470680479712415e-7	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,MTOR,PTPN11
PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.2	PI5P, PP2A and IER3 Regulate PI3K AKT Signaling	9.209520793910408e-7	9.209520793910408e-7	+1	PIK3CA,EGFR,PIK3R1,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20200810%WP45%HOMO SAPIENS	G1 to S cell cycle control	0.0000010347019118730412	0.0000010347019118730412	+1	TP53,CDKN2A,RB1,ATM,CDKN1B,CCND1,CDKN1A,CDKN2C
NEGATIVE REGULATION OF MITOTIC CELL CYCLE PHASE TRANSITION%GOBP%GO:1901991	negative regulation of mitotic cell cycle phase transition	0.0000011562198618496606	0.0000011562198618496606	+1	TP53,PTEN,APC,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN	Regulation of retinoblastoma protein	0.0000011562198618496606	0.0000011562198618496606	+1	CDKN2A,RB1,CEBPA,CDKN1B,EP300,CCND1,CDKN1A,TAF1
IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY	IFN-gamma pathway	0.0000011577323570091548	0.0000011577323570091548	+1	PIK3CA,PIK3R1,MAP3K1,AKT1,MTOR,EP300,PTPN11
WNT/BETA-CATENIN SIGNALING PATHWAY IN LEUKEMIA%WIKIPATHWAYS_20200810%WP3658%HOMO SAPIENS	Wnt/beta-catenin Signaling Pathway in Leukemia	0.0000012443752148189093	0.0000012443752148189093	+1	APC,CTNNB1,FLT3,AKT1,CCND1,AXIN2
FOXO-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 73%9614085	FOXO-mediated transcription	0.0000012470948849645503	0.0000012470948849645503	+1	STK11,AKT1,CDKN1B,EP300,SMAD4,CDKN1A,SIN3A,SMAD2
ERBB SIGNALING PATHWAY%GOBP%GO:0038127	ERBB signaling pathway	0.0000012470948849645503	0.0000012470948849645503	+1	PIK3CA,EGFR,PIK3R1,AKT1,BRAF,SOX9,ERBB4,PTPN11
REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	0.0000012470948849645503	0.0000012470948849645503	+1	RUNX1,CRIPAK,BRCA1,FOXA1,EP300,TAF1,CBFB,NCOR1
PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY	PID_RB_1PATHWAY	0.0000012470948849645503	0.0000012470948849645503	+1	CDKN2A,RB1,CEBPA,CDKN1B,EP300,CCND1,CDKN1A,TAF1
ONCOSTATIN M SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP2374%HOMO SAPIENS	Oncostatin M Signaling Pathway	0.0000012470948849645503	0.0000012470948849645503	+1	TP53,KRAS,PIK3R1,AKT1,CDKN1B,MTOR,PTPN11,LIFR
PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY	PID_ERBB2_ERBB3_PATHWAY	0.0000013054461396077057	0.0000013054461396077057	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,MTOR,PTPN11
REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE	Regulation of Telomerase	0.000001388877527505841	0.000001388877527505841	+1	EGFR,AKT1,ATM,CDKN1B,WT1,MTOR,CCND1,SIN3A
AMP-ACTIVATED PROTEIN KINASE (AMPK) SIGNALING%WIKIPATHWAYS_20200810%WP1403%HOMO SAPIENS	AMP-activated Protein Kinase (AMPK) Signaling	0.0000015439620081396594	0.0000015439620081396594	+1	TP53,PIK3CA,PIK3R1,STK11,AKT1,PIK3CG,MTOR,CDKN1A
PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY	PID_TELOMERASE_PATHWAY	0.0000015439620081396594	0.0000015439620081396594	+1	EGFR,AKT1,ATM,CDKN1B,WT1,MTOR,CCND1,SIN3A
EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0007173	epidermal growth factor receptor signaling pathway	0.0000017215901725908062	0.0000017215901725908062	+1	PIK3CA,EGFR,PIK3R1,AKT1,BRAF,SOX9,PTPN11
CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME%R-HSA-69231.7	Cyclin D associated events in G1	0.0000017215901725908062	0.0000017215901725908062	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
G1 PHASE%REACTOME DATABASE ID RELEASE 73%69236	G1 Phase	0.0000017215901725908062	0.0000017215901725908062	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY	FGF signaling pathway	0.0000017215901725908062	0.0000017215901725908062	+1	PIK3CA,PIK3R1,CDH1,AKT1,FGFR2,FGFR3,PTPN11
AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK	AP-1 transcription factor network	0.0000018517440247987614	0.0000018517440247987614	+1	TP53,PTEN,CDKN2A,CTNNB1,CDKN1B,EP300,CCND1,CBFB
PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY	PID_AP1_PATHWAY	0.0000018517440247987614	0.0000018517440247987614	+1	TP53,PTEN,CDKN2A,CTNNB1,CDKN1B,EP300,CCND1,CBFB
PHOSPHATIDYLINOSITOL-MEDIATED SIGNALING%GOBP%GO:0048015	phosphatidylinositol-mediated signaling	0.0000018517440247987614	0.0000018517440247987614	+1	PIK3CA,PTEN,NF1,PIK3R1,GATA3,AKT1,PIK3CG,PDGFRA
RAS PATHWAY%PANTHER PATHWAY%P04393	Ras Pathway	0.0000018517440247987614	0.0000018517440247987614	+1	PIK3CA,KRAS,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,PIK3CG
SMALL CELL LUNG CANCER%WIKIPATHWAYS_20200810%WP4658%HOMO SAPIENS	Small cell lung cancer	0.000001851899664893105	0.000001851899664893105	+1	TP53,PIK3CA,PTEN,PIK3R1,RB1,AKT1,CDKN1B,CCND1,CDKN1A
SA_G1_AND_S_PHASES%MSIGDB_C2%SA_G1_AND_S_PHASES	SA_G1_AND_S_PHASES	0.0000020751597135628694	0.0000020751597135628694	+1	TP53,CDKN2A,CDKN1B,CCND1,CDKN1A
TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20200810%WP4566%HOMO SAPIENS	Translation inhibitors in chronically activated PDGFRA cells	0.0000022403006574158586	0.0000022403006574158586	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PIK3CG,MTOR,EIF4A2
INOSITOL LIPID-MEDIATED SIGNALING%GOBP%GO:0048017	inositol lipid-mediated signaling	0.000002262685248353919	0.000002262685248353919	+1	PIK3CA,PTEN,NF1,PIK3R1,GATA3,AKT1,PIK3CG,PDGFRA
POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE SIGNALING%GOBP%GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	0.000002510010275714365	0.000002510010275714365	+1	PIK3CA,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
PROTEIN STABILIZATION%GOBP%GO:0050821	protein stabilization	0.000002700629286963963	0.000002700629286963963	+1	PTEN,VHL,PIK3R1,FBXW7,CHEK2,EP300,USP9X,SOX17,CDKN1A,TAF1,RPL5
PEPTIDYL-TYROSINE PHOSPHORYLATION%GOBP%GO:0018108	peptidyl-tyrosine phosphorylation	0.0000027635875790278352	0.0000027635875790278352	+1	EGFR,FLT3,EPHA3,ERBB4,KIT,PDGFRA,FGFR2,FGFR3
BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY	BIOCARTA_BCELLSURVIVAL_PATHWAY	0.0000028784797767927042	0.0000028784797767927042	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,MTOR
BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY	BIOCARTA_P53_PATHWAY	0.0000028784797767927042	0.0000028784797767927042	+1	TP53,RB1,ATM,CCND1,CDKN1A
HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20200810%WP3646%HOMO SAPIENS	Hepatitis C and Hepatocellular Carcinoma	0.0000028800510738859707	0.0000028800510738859707	+1	TP53,AKT1,BRCA1,CCND1,SMAD4,CDKN1A,PTPN11
RESPONSE TO LIGHT STIMULUS%GOBP%GO:0009416	response to light stimulus	0.000002942501337335389	0.000002942501337335389	+1	TP53,EGFR,NF1,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0030330	DNA damage response, signal transduction by p53 class mediator	0.000002986500355087121	0.000002986500355087121	+1	TP53,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A
WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20200810%WP399%HOMO SAPIENS	Wnt Signaling Pathway and Pluripotency	0.0000031515276632950846	0.0000031515276632950846	+1	TP53,APC,CTNNB1,MAP2K4,LRRK2,EP300,CCND1,PPP2R1A,AXIN2
POSITIVE REGULATION OF ANIMAL ORGAN MORPHOGENESIS%GOBP%GO:0110110	positive regulation of animal organ morphogenesis	0.0000032065188709472892	0.0000032065188709472892	+1	GATA3,NOTCH1,SOX9,WT1,FGFR2,SMAD4,TGFBR2
SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 73%9006927	Signaling by Non-Receptor Tyrosine Kinases	0.0000032065188709472892	0.0000032065188709472892	+1	EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
SIGNALING BY PTK6%REACTOME%R-HSA-8848021.2	Signaling by PTK6	0.0000032065188709472892	0.0000032065188709472892	+1	EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20200810%WP615%HOMO SAPIENS	Senescence and Autophagy in Cancer	0.0000033462453647787973	0.0000033462453647787973	+1	TP53,PTEN,CDKN2A,RB1,BRAF,CDKN1B,MTOR,SMAD4,CDKN1A
CELL CYCLE CHECKPOINT%GOBP%GO:0000075	cell cycle checkpoint	0.000003531768639774556	0.000003531768639774556	+1	TP53,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
PEPTIDYL-TYROSINE MODIFICATION%GOBP%GO:0018212	peptidyl-tyrosine modification	0.000003531768639774556	0.000003531768639774556	+1	EGFR,FLT3,EPHA3,ERBB4,KIT,PDGFRA,FGFR2,FGFR3
REGULATION OF SISTER CHROMATID SEGREGATION%GOBP%GO:0033045	regulation of sister chromatid segregation	0.000003531768639774556	0.000003531768639774556	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,AXIN2,RAD21
EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY	EGF receptor (ErbB1) signaling pathway	0.0000037077617224880114	0.0000037077617224880114	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,PTPN11
SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 73%5654741	Signaling by FGFR3	0.0000037077617224880114	0.0000037077617224880114	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY	BIOCARTA_PDGF_PATHWAY	0.0000037077617224880114	0.0000037077617224880114	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,PIK3CG,PDGFRA
SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0072331	signal transduction by p53 class mediator	0.0000037882668539863006	0.0000037882668539863006	+1	TP53,STK11,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A
REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20200810%WP4838%HOMO SAPIENS	Regucalcin in proximal tubule epithelial kidney cells	0.000004432225321371978	0.000004432225321371978	+1	PIK3CA,AKT1,BRAF,MTOR,SMAD4,SMAD2
BDNF-TRKB SIGNALING%WIKIPATHWAYS_20200810%WP3676%HOMO SAPIENS	BDNF-TrkB Signaling	0.000004432225321371978	0.000004432225321371978	+1	KRAS,NRAS,AKT1,BRAF,PIK3CG,MTOR
ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20200810%WP2853%HOMO SAPIENS	Endoderm Differentiation	0.000004436984716745244	0.000004436984716745244	+1	APC,NOTCH1,CTNNB1,FOXA1,SMAD4,FOXA2,SOX17,PHF6,SMAD2,EZH2
BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY	BIOCARTA_TEL_PATHWAY	0.000004999131399602298	0.000004999131399602298	+1	TP53,KRAS,EGFR,RB1,AKT1
BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY	BIOCARTA_PTEN_PATHWAY	0.000004999131399602298	0.000004999131399602298	+1	PIK3CA,PTEN,PIK3R1,AKT1,CDKN1B
IL-4 SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP395%HOMO SAPIENS	IL-4 Signaling Pathway	0.0000050838140596984505	0.0000050838140596984505	+1	PIK3CA,PIK3R1,GATA3,CEBPA,AKT1,EP300,PTPN11
ST_INTEGRIN_SIGNALING_PATHWAY%MSIGDB_C2%ST_INTEGRIN_SIGNALING_PATHWAY	ST_INTEGRIN_SIGNALING_PATHWAY	0.000005444930922162213	0.000005444930922162213	+1	PIK3CA,PTEN,CDKN2A,ARHGAP35,MAP2K4,AKT1,BRAF,MAPK8IP1
SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME DATABASE ID RELEASE 73%8853334	Signaling by FGFR3 fusions in cancer	0.0000057115451640135155	0.0000057115451640135155	+1	PIK3CA,PIK3R1,NRAS,FGFR3
EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018	EGF receptor signaling pathway	0.00000576424742640252	0.00000576424742640252	+1	PIK3CA,EGFR,NF1,NRAS,MAP2K4,AKT1,BRAF,PIK3CG,ERBB4
SIGNALING BY FGFR4%REACTOME%R-HSA-5654743.2	Signaling by FGFR4	0.0000061243162662465225	0.0000061243162662465225	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	0.0000061243162662465225	0.0000061243162662465225	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,PTPN11
SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING	SHP2 signaling	0.0000063436389925109994	0.0000063436389925109994	+1	PIK3CA,KRAS,EGFR,PIK3R1,ARHGAP35,NRAS,PTPN11
TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA	Trk receptor signaling mediated by PI3K and PLC-gamma	0.000007020920870072888	0.000007020920870072888	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,CCND1
PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY	PID_SHP2_PATHWAY	0.000007020920870072888	0.000007020920870072888	+1	PIK3CA,KRAS,EGFR,PIK3R1,ARHGAP35,NRAS,PTPN11
PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY	PID_PI3K_PLC_TRK_PATHWAY	0.000007020920870072888	0.000007020920870072888	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,CCND1
MEIOSIS%REACTOME DATABASE ID RELEASE 73%1500620	Meiosis	0.000007020920870072888	0.000007020920870072888	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION	E-cadherin signaling in the nascent adherens junction	0.000007020920870072888	0.000007020920870072888	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,AKT1,CCND1
CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING	CD40 CD40L signaling	0.000007020920870072888	0.000007020920870072888	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG
NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY	Notch signaling pathway	0.000007020920870072888	0.000007020920870072888	+1	GATA3,NOTCH1,FBXW7,EP300,CCND1,CDKN1A,NCOR1
REGULATION OF ERK1 AND ERK2 CASCADE%GOBP%GO:0070372	regulation of ERK1 and ERK2 cascade	0.000007084031541375515	0.000007084031541375515	+1	PTEN,EGFR,NOTCH1,FBXW7,BRAF,ERBB4,TLR4,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME%R-HSA-8878166.2	Transcriptional regulation by RUNX2	0.000007304313901782954	0.000007304313901782954	+1	RB1,RUNX1,AKT1,AR,SOX9,CCND1,SMAD4,CDKN1A,CBFB
CELLULAR SENESCENCE%REACTOME%R-HSA-2559583.4	Cellular Senescence	0.0000073478598760047435	0.0000073478598760047435	+1	TP53,CDKN2A,RB1,MAP2K4,ATM,CDKN1B,HIST1H1C,CDKN1A,HIST1H2BD,CDKN2C,EZH2
PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY	PID_ATF2_PATHWAY	0.000007553391599222986	0.000007553391599222986	+1	NF1,RB1,BRCA1,PDGFRA,EP300,CCND1,CBFB
PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY	PID_NOTCH_PATHWAY	0.000007553391599222986	0.000007553391599222986	+1	GATA3,NOTCH1,FBXW7,EP300,CCND1,CDKN1A,NCOR1
ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK	ATF-2 transcription factor network	0.000007553391599222986	0.000007553391599222986	+1	NF1,RB1,BRCA1,PDGFRA,EP300,CCND1,CBFB
THE OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS THAT CONTRIBUTE TO A RANGE OF LMNA LAMINOPATHIES%WIKIPATHWAYS_20200810%WP4879%HOMO SAPIENS	The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies	0.000007553391599222986	0.000007553391599222986	+1	APC,RB1,NOTCH1,CTNNB1,CEBPA,CDKN1A,SMAD2
OSTEOBLAST DIFFERENTIATION%WIKIPATHWAYS_20200810%WP4787%HOMO SAPIENS	Osteoblast differentiation	0.00000763220286920968	0.00000763220286920968	+1	PIK3CA,PIK3R1,NOTCH1,CTNNB1,PIK3CG,SOX9,FGFR2,SMAD4,FGFR3
BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY	BIOCARTA_ATM_PATHWAY	0.000007838637309742108	0.000007838637309742108	+1	TP53,ATM,BRCA1,CHEK2,CDKN1A
NEGATIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	0.000007838637309742108	0.000007838637309742108	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B
BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY	BIOCARTA_MET_PATHWAY	0.000007838637309742108	0.000007838637309742108	+1	PIK3CA,PTEN,PIK3R1,PIK3CG,HGF,PTPN11
BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY	BIOCARTA_IGF1MTOR_PATHWAY	0.000007838637309742108	0.000007838637309742108	+1	PIK3CA,PTEN,PIK3R1,AKT1,MTOR
BMP SIGNALING PATHWAY IN EYELID DEVELOPMENT%WIKIPATHWAYS_20200810%WP3927%HOMO SAPIENS	BMP Signaling Pathway in Eyelid Development	0.000007838637309742108	0.000007838637309742108	+1	EGFR,NOTCH1,MAP3K1,FGFR2,SMAD4
RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20200810%WP2446%HOMO SAPIENS	Retinoblastoma Gene in Cancer	0.00000833788634600758	0.00000833788634600758	+1	TP53,RB1,CDKN1B,CCND1,CDKN1A,SIN3A,SMC1A,SMC3
FOCAL ADHESION%WIKIPATHWAYS_20200810%WP306%HOMO SAPIENS	Focal Adhesion	0.000008956728939407628	0.000008956728939407628	+1	PIK3CA,PTEN,EGFR,PIK3R1,CTNNB1,ARHGAP35,AKT1,BRAF,HGF,PDGFRA,CCND1
ANOIKIS%GOBP%GO:0043276	anoikis	0.000008982216776679238	0.000008982216776679238	+1	PIK3CA,STK11,AKT1,MTOR
CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS	CXCR3-mediated signaling events	0.000009031090435507097	0.000009031090435507097	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,MTOR
SISTER CHROMATID COHESION%GOBP%GO:0007062	sister chromatid cohesion	0.000009031090435507097	0.000009031090435507097	+1	RB1,FBXW7,STAG2,SMC1A,SMC3,RAD21
T CELL ACTIVATION%PANTHER PATHWAY%P00053	T cell activation	0.000009031090435507097	0.000009031090435507097	+1	PIK3CA,PIK3R1,MAP3K1,NRAS,AKT1,BRAF,PIK3CG
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME%R-HSA-2219530.1	Constitutive Signaling by Aberrant PI3K in Cancer	0.000010027292809933615	0.000010027292809933615	+1	PIK3CA,EGFR,PIK3R1,HGF,KIT,PDGFRA,PTPN11
MITOTIC G1 DNA DAMAGE CHECKPOINT%GOBP%GO:0031571	mitotic G1 DNA damage checkpoint	0.000010027292809933615	0.000010027292809933615	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY	PID_ECADHERIN_NASCENT_AJ_PATHWAY	0.000010432107574378148	0.000010432107574378148	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,AKT1,CCND1
DNA DAMAGE CHECKPOINT%GOBP%GO:0000077	DNA damage checkpoint	0.00001085162613198851	0.00001085162613198851	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
MITOTIC G1/S TRANSITION CHECKPOINT%GOBP%GO:0044819	mitotic G1/S transition checkpoint	0.000011016005353495595	0.000011016005353495595	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
G1 DNA DAMAGE CHECKPOINT%GOBP%GO:0044783	G1 DNA damage checkpoint	0.000011016005353495595	0.000011016005353495595	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
ATM SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP2516%HOMO SAPIENS	ATM Signaling Pathway	0.000011884861584007996	0.000011884861584007996	+1	TP53,ATM,BRCA1,CHEK2,CDKN1A,SMC1A
PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY	PID_FOXM1_PATHWAY	0.000011884861584007996	0.000011884861584007996	+1	CDKN2A,RB1,CHEK2,EP300,CCND1,BRCA2
MAMMARY GLAND DEVELOPMENT%GOBP%GO:0030879	mammary gland development	0.000011884861584007996	0.000011884861584007996	+1	ARHGAP35,TBX3,AKT1,ERBB4,ELF3,FGFR2
REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:1901796	regulation of signal transduction by p53 class mediator	0.000013355253779783787	0.000013355253779783787	+1	TP53,STK11,AKT1,ATM,BRCA1,CHEK2,EP300,TAF1,ATR,RPL5
SIGNALING BY FGFR1%REACTOME%R-HSA-5654736.4	Signaling by FGFR1	0.000013718387196303025	0.000013718387196303025	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 73%9673767	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	0.000013827148289298357	0.000013827148289298357	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 73%9673770	Signaling by PDGFRA extracellular domain mutants	0.000013827148289298357	0.000013827148289298357	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 73%2470946	Cohesin Loading onto Chromatin	0.000013827148289298357	0.000013827148289298357	+1	STAG2,SMC1A,SMC3,RAD21
BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY	BIOCARTA_RAC1_PATHWAY	0.000015245714052475098	0.000015245714052475098	+1	PIK3CA,PIK3R1,MAP3K1,PIK3CG,PDGFRA
REGULATION OF ANIMAL ORGAN MORPHOGENESIS%GOBP%GO:2000027	regulation of animal organ morphogenesis	0.000015340016990121104	0.000015340016990121104	+1	GATA3,NOTCH1,FBXW7,CTNNB1,SOX9,WT1,HGF,FGFR2,SMAD4,TGFBR2
FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK	FOXM1 transcription factor network	0.00001551192661850252	0.00001551192661850252	+1	CDKN2A,RB1,CHEK2,EP300,CCND1,BRCA2
MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20200810%WP1544%HOMO SAPIENS	MicroRNAs in cardiomyocyte hypertrophy	0.000015920204354145795	0.000015920204354145795	+1	PIK3CA,PIK3R1,CTNNB1,MAP2K4,AKT1,PIK3CG,MTOR,FGFR2
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	0.000015920204354145795	0.000015920204354145795	+1	PIK3CA,PTEN,CDKN2A,AKT1,CDKN1B,ERBB4,MTOR
SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE%GOBP%GO:0042770	signal transduction in response to DNA damage	0.000015920204354145795	0.000015920204354145795	+1	TP53,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A
CHROMATIN REMODELING%GOBP%GO:0006338	chromatin remodeling	0.000016731397602801136	0.000016731397602801136	+1	ARID1A,PBRM1,CDKN2A,RB1,NPM1,KDM6A,SOX9,KDM5C,ATRX,FOXA1
HUMAN THYROID STIMULATING HORMONE (TSH) SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP2032%HOMO SAPIENS	Human Thyroid Stimulating Hormone (TSH) signaling pathway	0.000017412967318053286	0.000017412967318053286	+1	PIK3CA,PIK3R1,RB1,AKT1,BRAF,CDKN1B,MTOR
PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY	PID_CXCR3_PATHWAY	0.000017412967318053286	0.000017412967318053286	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,MTOR
CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS	Class I PI3K signaling events	0.000017412967318053286	0.000017412967318053286	+1	PIK3CA,PTEN,KRAS,PIK3R1,NRAS,PIK3CG
REGULATION OF CHROMOSOME SEGREGATION%GOBP%GO:0051983	regulation of chromosome segregation	0.000018224552205929095	0.000018224552205929095	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,AXIN2,RAD21
DNA INTEGRITY CHECKPOINT%GOBP%GO:0031570	DNA integrity checkpoint	0.000018985196165637288	0.000018985196165637288	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
METANEPHROS DEVELOPMENT%GOBP%GO:0001656	metanephros development	0.0000196433685183102	0.0000196433685183102	+1	NF1,GATA3,SOX9,WT1,PDGFRA,SOX17
FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK	FOXA1 transcription factor network	0.0000196433685183102	0.0000196433685183102	+1	AR,CDKN1B,BRCA1,FOXA1,EP300,FOXA2
PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY	PID_HNF3A_PATHWAY	0.0000196433685183102	0.0000196433685183102	+1	AR,CDKN1B,BRCA1,FOXA1,EP300,FOXA2
ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2468052.1	Establishment of Sister Chromatid Cohesion	0.000020249102298175507	0.000020249102298175507	+1	STAG2,SMC1A,SMC3,RAD21
SIGNAL TRANSDUCTION INVOLVED IN DNA DAMAGE CHECKPOINT%GOBP%GO:0072422	signal transduction involved in DNA damage checkpoint	0.000020529755548340576	0.000020529755548340576	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
SIGNAL TRANSDUCTION INVOLVED IN DNA INTEGRITY CHECKPOINT%GOBP%GO:0072401	signal transduction involved in DNA integrity checkpoint	0.000020529755548340576	0.000020529755548340576	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY	PID_P53_DOWNSTREAM_PATHWAY	0.000020901621683815113	0.000020901621683815113	+1	TP53,PTEN,APC,EGFR,RB1,HGF,FOXA1,EP300,CDKN1A
REGULATION OF LIPID KINASE ACTIVITY%GOBP%GO:0043550	regulation of lipid kinase activity	0.000022023075291100244	0.000022023075291100244	+1	PIK3R1,RB1,FLT3,KIT,PDGFRA,FGFR3
REGULATION OF CELL CYCLE ARREST%GOBP%GO:0071156	regulation of cell cycle arrest	0.000022023075291100244	0.000022023075291100244	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A
CELLULAR RESPONSE TO EXTERNAL STIMULUS%GOBP%GO:0071496	cellular response to external stimulus	0.00002214368353966869	0.00002214368353966869	+1	TP53,MAP3K1,ARHGAP35,MAP2K4,SOX9,MTOR,TLR4,LRRK2,FOXA2,CDKN1A,TAF1
EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 73%9009391	Extra-nuclear estrogen signaling	0.00002214368353966869	0.00002214368353966869	+1	PIK3CA,EGFR,PIK3R1,NRAS,AKT1,CDKN1B,CCND1
SIGNAL TRANSDUCTION INVOLVED IN CELL CYCLE CHECKPOINT%GOBP%GO:0072395	signal transduction involved in cell cycle checkpoint	0.00002214368353966869	0.00002214368353966869	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
CELL FATE COMMITMENT%GOBP%GO:0045165	cell fate commitment	0.000024495104359143653	0.000024495104359143653	+1	APC,GATA3,TBX3,SOX9,WT1,FGFR2,FOXA2,SOX17,SMAD2
ATM SIGNALING NETWORK IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20200810%WP3878%HOMO SAPIENS	ATM Signaling Network in Development and Disease	0.0000245832811634942	0.0000245832811634942	+1	STK11,ATM,MTOR,CHEK2,ATR,SMC1A
HEART VALVE MORPHOGENESIS%GOBP%GO:0003179	heart valve morphogenesis	0.0000245832811634942	0.0000245832811634942	+1	GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2
FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021	FGF signaling pathway	0.000024871567875767172	0.000024871567875767172	+1	PIK3CA,NRAS,MAP2K4,AKT1,PIK3CG,FGFR2,FGFR3,PPP2R1A
REPRODUCTIVE STRUCTURE DEVELOPMENT%GOBP%GO:0048608	reproductive structure development	0.000025422042528316536	0.000025422042528316536	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS	Direct p53 effectors	0.000025422042528316536	0.000025422042528316536	+1	TP53,PTEN,APC,EGFR,RB1,HGF,FOXA1,EP300,CDKN1A
REPRODUCTIVE SYSTEM DEVELOPMENT%GOBP%GO:0061458	reproductive system development	0.000025422042528316536	0.000025422042528316536	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY	BIOCARTA_BAD_PATHWAY	0.00002582855327469318	0.00002582855327469318	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,KIT
DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-HSA-186763.2	Downstream signal transduction	0.00002582855327469318	0.00002582855327469318	+1	PIK3CA,PIK3R1,NRAS,PDGFRA,PTPN11
NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK	Notch-mediated HES HEY network	0.000027091370546441965	0.000027091370546441965	+1	RB1,NOTCH1,AR,CDKN1B,EP300,NCOR1
VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS	Validated transcriptional targets of deltaNp63 isoforms	0.000027091370546441965	0.000027091370546441965	+1	CDKN2A,NOTCH1,FBXW7,RUNX1,ATM,BRCA2
PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY	PID_DELTA_NP63_PATHWAY	0.000027091370546441965	0.000027091370546441965	+1	CDKN2A,NOTCH1,FBXW7,RUNX1,ATM,BRCA2
REPRODUCTION%REACTOME DATABASE ID RELEASE 73%1474165	Reproduction	0.000027875443745271136	0.000027875443745271136	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
MITOTIC CELL CYCLE CHECKPOINT%GOBP%GO:0007093	mitotic cell cycle checkpoint	0.000027875443745271136	0.000027875443745271136	+1	TP53,APC,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
REGULATION OF EPITHELIAL CELL PROLIFERATION%GOBP%GO:0050678	regulation of epithelial cell proliferation	0.000029583495667547427	0.000029583495667547427	+1	EGFR,NF1,GATA3,FBXW7,NRAS,AKT1,SOX9,TLR4,FGFR2,BRCA2,EGR3
PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY	PID_HES_HEY_PATHWAY	0.000030328375488140423	0.000030328375488140423	+1	RB1,NOTCH1,AR,CDKN1B,EP300,NCOR1
BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY	BIOCARTA_EDG1_PATHWAY	0.000030607198154695066	0.000030607198154695066	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,PDGFRA
REGULATION OF CENTROMERIC SISTER CHROMATID COHESION%GOBP%GO:0070602	regulation of centromeric sister chromatid cohesion	0.00003074749991208289	0.00003074749991208289	+1	CTNNB1,CTCF,AXIN2
SIGNALING BY NOTCH%REACTOME%R-HSA-157118.5	Signaling by NOTCH	0.000031722266932398886	0.000031722266932398886	+1	TP53,EGFR,NOTCH1,RUNX1,AKT1,ELF3,EP300,CCND1,HIST1H2BD,TBL1XR1,NCOR1
NOTCH%NETPATH%NOTCH	Notch	0.000032398678353279734	0.000032398678353279734	+1	PIK3R1,NOTCH1,FBXW7,AKT1,EP300,SIN3A,NCOR1
EPITHELIAL TUBE MORPHOGENESIS%GOBP%GO:0060562	epithelial tube morphogenesis	0.000032398678353279734	0.000032398678353279734	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,WT1,FGFR2,TGFBR2,SOX17
POSITIVE REGULATION OF CELL CYCLE ARREST%GOBP%GO:0071158	positive regulation of cell cycle arrest	0.000032398678353279734	0.000032398678353279734	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS%WIKIPATHWAYS_20200810%WP2572%HOMO SAPIENS	Primary Focal Segmental Glomerulosclerosis FSGS	0.000032398678353279734	0.000032398678353279734	+1	NOTCH1,CTNNB1,AKT1,CDKN1B,WT1,TLR4,CDKN1A
PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY	PID_PI3KCI_PATHWAY	0.00003339009984096186	0.00003339009984096186	+1	PIK3CA,PTEN,KRAS,PIK3R1,NRAS,PIK3CG
MESENCHYME DEVELOPMENT%GOBP%GO:0060485	mesenchyme development	0.00003373925689105229	0.00003373925689105229	+1	NOTCH1,CTNNB1,SOX9,WT1,HGF,ERBB4,FGFR2,TGFBR2,SMAD2
MEIOTIC SYNAPSIS%REACTOME%R-HSA-1221632.1	Meiotic synapsis	0.000034939394729990493	0.000034939394729990493	+1	STAG2,BRCA1,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.3	Transcriptional regulation by RUNX1	0.000034939394729990493	0.000034939394729990493	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,CCND1,CBFB,SIN3A,HIST1H2BD,PTPN11,LIFR
SEX DIFFERENTIATION%GOBP%GO:0007548	sex differentiation	0.000034942655475713094	0.000034942655475713094	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,PTPN11
POSITIVE REGULATION OF DNA-BINDING TRANSCRIPTION FACTOR ACTIVITY%GOBP%GO:0051091	positive regulation of DNA-binding transcription factor activity	0.0000361559493215567	0.0000361559493215567	+1	PTEN,CTNNB1,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,TAF1
CELL DIVISION%REACTOME%R-HSA-68884.3	cell division	0.00003711783760239035	0.00003711783760239035	+1	STAG2,SMC1A,SMC3,RAD21
SIGNALING BY EGFRVIII IN CANCER%REACTOME DATABASE ID RELEASE 73%5637812	Signaling by EGFRvIII in Cancer	0.00003711783760239035	0.00003711783760239035	+1	PIK3CA,EGFR,PIK3R1,NRAS
NOTCH%IOB%NOTCH	Notch	0.00003711783760239035	0.00003711783760239035	+1	PIK3R1,NOTCH1,FBXW7,EP300,SMAD4,SIN3A,NCOR1
SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 73%1502540	Signaling by Activin	0.00003711783760239035	0.00003711783760239035	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 73%5637810	Constitutive Signaling by EGFRvIII	0.00003711783760239035	0.00003711783760239035	+1	PIK3CA,EGFR,PIK3R1,NRAS
CELLULAR RESPONSE TO UV%GOBP%GO:0034644	cellular response to UV	0.00003711783760239035	0.00003711783760239035	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
HEART VALVE DEVELOPMENT%GOBP%GO:0003170	heart valve development	0.000040632185823479115	0.000040632185823479115	+1	GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2
SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)	Signaling events mediated by Stem cell factor receptor (c-Kit)	0.000040632185823479115	0.000040632185823479115	+1	PIK3CA,PTEN,PIK3R1,AKT1,KIT,PTPN11
PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY	PID_BARD1_PATHWAY	0.000041380248782899155	0.000041380248782899155	+1	TP53,NPM1,ATM,BRCA1,ATR
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 73%2559586	DNA Damage Telomere Stress Induced Senescence	0.00004333108558131402	0.00004333108558131402	+1	TP53,RB1,ATM,CDKN1B,HIST1H1C,CDKN1A,HIST1H2BD
INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036	Interleukin signaling pathway	0.00004333108558131402	0.00004333108558131402	+1	PIK3CA,NRAS,AKT1,BRAF,CDKN1B,MTOR,CDKN1A
REGULATION OF PEPTIDYL-TYROSINE PHOSPHORYLATION%GOBP%GO:0050730	regulation of peptidyl-tyrosine phosphorylation	0.00004430734040203923	0.00004430734040203923	+1	TP53,EGFR,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PPP2R1A,PTPN11
PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY	PID_KIT_PATHWAY	0.00004460746699653095	0.00004460746699653095	+1	PIK3CA,PTEN,PIK3R1,AKT1,KIT,PTPN11
REGULATION OF OXIDATIVE STRESS-INDUCED CELL DEATH%GOBP%GO:1903201	regulation of oxidative stress-induced cell death	0.00004460746699653095	0.00004460746699653095	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
WNT SIGNALING PATHWAY (NETPATH)%WIKIPATHWAYS_20200810%WP363%HOMO SAPIENS	Wnt Signaling Pathway (Netpath)	0.00004460746699653095	0.00004460746699653095	+1	APC,CTNNB1,AKT1,MTOR,CCND1,AXIN2
REGULATION OF DEVELOPMENTAL GROWTH%GOBP%GO:0048638	regulation of developmental growth	0.00004623767010600688	0.00004623767010600688	+1	PTEN,NOTCH1,CDKN1B,WT1,ERBB4,FGFR2,FGFR3,CDKN1A,SIN3A
DNA IR-DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20200810%WP4016%HOMO SAPIENS	DNA IR-damage and cellular response via ATR	0.00004623767010600688	0.00004623767010600688	+1	TP53,ATM,BRCA1,CHEK2,BRCA2,ATR,SMC1A
SIGNALING BY ERBB2 ECD MUTANTS%REACTOME%R-HSA-9665348.2	Signaling by ERBB2 ECD mutants	0.00004963087876513795	0.00004963087876513795	+1	PIK3CA,EGFR,PIK3R1,NRAS
HALLMARK_G2M_CHECKPOINT%MSIGDB_C2%HALLMARK_G2M_CHECKPOINT	HALLMARK_G2M_CHECKPOINT	0.00004963087876513795	0.00004963087876513795	+1	CTCF,CDKN1B,ATRX,POLQ,CCND1,BRCA2,SMC1A,RAD21,CDKN2C,EZH2
CHROMATIN ASSEMBLY OR DISASSEMBLY%GOBP%GO:0006333	chromatin assembly or disassembly	0.00005093538981210604	0.00005093538981210604	+1	TP53,ARID1A,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD
WNT%IOB%WNT	Wnt	0.00005171723186632199	0.00005171723186632199	+1	APC,CTNNB1,MAP3K1,CDH1,MAP2K4,AKT1,CCND1,AXIN2
POSITIVE REGULATION OF CHROMOSOME ORGANIZATION%GOBP%GO:2001252	positive regulation of chromosome organization	0.00005334596169558957	0.00005334596169558957	+1	RB1,CTNNB1,ATM,ATRX,BRCA1,SMAD4,ATR,SIN3A,RAD21
EMBRYONIC ORGAN DEVELOPMENT%GOBP%GO:0048568	embryonic organ development	0.00005358754547449001	0.00005358754547449001	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,KIT,PDGFRA,FGFR2,TGFBR2,SOX17
COPPER HOMEOSTASIS%WIKIPATHWAYS_20200810%WP3286%HOMO SAPIENS	Copper homeostasis	0.00005412707434478326	0.00005412707434478326	+1	TP53,PIK3CA,PTEN,APC,AKT1,CCND1
MALE SEX DIFFERENTIATION%GOBP%GO:0046661	male sex differentiation	0.00005412707434478326	0.00005412707434478326	+1	GATA3,TBX3,AR,SOX9,WT1,KIT
WNT%NETPATH%WNT	Wnt	0.00005426087381781676	0.00005426087381781676	+1	APC,CTNNB1,MAP3K1,CDH1,MAP2K4,AKT1,CCND1,AXIN2
REGULATION OF INTRACELLULAR ESTROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033146	regulation of intracellular estrogen receptor signaling pathway	0.000055019820139639344	0.000055019820139639344	+1	RUNX1,CRIPAK,BRCA1,FOXA1,CBFB
BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY	BIOCARTA_EGF_PATHWAY	0.000055019820139639344	0.000055019820139639344	+1	PIK3CA,EGFR,PIK3R1,MAP3K1,MAP2K4
POSITIVE REGULATION OF UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	0.000056865902795506645	0.000056865902795506645	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
IL6%NETPATH%IL6	IL6	0.00006138664761457504	0.00006138664761457504	+1	PIK3R1,RB1,MAP2K4,AKT1,AR,EP300,PTPN11
POSITIVE REGULATION OF DNA METABOLIC PROCESS%GOBP%GO:0051054	positive regulation of DNA metabolic process	0.00006230936873470691	0.00006230936873470691	+1	EGFR,AKT1,ATM,WT1,HGF,ATRX,BRCA1,USP9X,ATR,ERCC2
INSULIN SIGNALING%WIKIPATHWAYS_20200810%WP481%HOMO SAPIENS	Insulin Signaling	0.00006357290487858974	0.00006357290487858974	+1	PIK3CA,PTEN,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG,MTOR,PTPN11
BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY	BIOCARTA_LONGEVITY_PATHWAY	0.00006402517861220903	0.00006402517861220903	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
H19 ACTION RB-E2F1 SIGNALING AND CDK-BETA-CATENIN ACTIVITY%WIKIPATHWAYS_20200810%WP3969%HOMO SAPIENS	H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity	0.00006402517861220903	0.00006402517861220903	+1	RB1,CTNNB1,CDH1,CCND1
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 73%8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	0.00006492432443020787	0.00006492432443020787	+1	RUNX1,CBFB,LIFR
DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR RESULTING IN CELL CYCLE ARREST%GOBP%GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	0.00006492432443020787	0.00006492432443020787	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 73%8851907	MET activates PI3K AKT signaling	0.00006492432443020787	0.00006492432443020787	+1	PIK3CA,PIK3R1,HGF
CELLULAR RESPONSE TO INDOLE-3-METHANOL%GOBP%GO:0071681	cellular response to indole-3-methanol	0.00006492432443020787	0.00006492432443020787	+1	CTNNB1,CDH1,BRCA1
RESPONSE TO INDOLE-3-METHANOL%GOBP%GO:0071680	response to indole-3-methanol	0.00006492432443020787	0.00006492432443020787	+1	CTNNB1,CDH1,BRCA1
TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER%GOBP%GO:0006367	transcription initiation from RNA polymerase II promoter	0.00006507931836863115	0.00006507931836863115	+1	PTEN,NOTCH1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
S PHASE%REACTOME%R-HSA-69242.2	S Phase	0.00006507931836863115	0.00006507931836863115	+1	RB1,AKT1,STAG2,CDKN1B,CCND1,CDKN1A,SMC1A,SMC3,RAD21
FRAGILE X SYNDROME %WIKIPATHWAYS_20200810%WP4549%HOMO SAPIENS	Fragile X Syndrome	0.00006629421405642505	0.00006629421405642505	+1	PTEN,KRAS,NF1,CDKN2A,AKT1,BRAF,MTOR,PTPN11
EGF/EGFR SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP437%HOMO SAPIENS	EGF/EGFR Signaling Pathway	0.00006803424726672425	0.00006803424726672425	+1	PTEN,KRAS,EGFR,PIK3R1,MAP3K1,AKT1,BRAF,MTOR,PTPN11
BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY	BIOCARTA_PPARA_PATHWAY	0.00006939623324308646	0.00006939623324308646	+1	PIK3CA,PIK3R1,RB1,PIK3CG,EP300,NCOR1
SIGNAL TRANSDUCTION INVOLVED IN MITOTIC DNA INTEGRITY CHECKPOINT%GOBP%GO:1902403	signal transduction involved in mitotic DNA integrity checkpoint	0.00006939623324308646	0.00006939623324308646	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
INTRACELLULAR SIGNAL TRANSDUCTION INVOLVED IN G1 DNA DAMAGE CHECKPOINT%GOBP%GO:1902400	intracellular signal transduction involved in G1 DNA damage checkpoint	0.00006939623324308646	0.00006939623324308646	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
SIGNAL TRANSDUCTION INVOLVED IN MITOTIC G1 DNA DAMAGE CHECKPOINT%GOBP%GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint	0.00006939623324308646	0.00006939623324308646	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
SIGNAL TRANSDUCTION INVOLVED IN MITOTIC CELL CYCLE CHECKPOINT%GOBP%GO:0072413	signal transduction involved in mitotic cell cycle checkpoint	0.00006939623324308646	0.00006939623324308646	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
SIGNAL TRANSDUCTION INVOLVED IN MITOTIC DNA DAMAGE CHECKPOINT%GOBP%GO:1902402	signal transduction involved in mitotic DNA damage checkpoint	0.00006939623324308646	0.00006939623324308646	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
MAPK CASCADE%WIKIPATHWAYS_20200810%WP422%HOMO SAPIENS	MAPK Cascade	0.00007104412121575039	0.00007104412121575039	+1	KRAS,MAP3K1,NRAS,MAP2K4,BRAF
POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE/THREONINE KINASE SIGNALING PATHWAY%GOBP%GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.00007273611659154987	0.00007273611659154987	+1	NOTCH1,STK11,EP300,SMAD4,ACVR1B,ACVR2A,SMAD2
SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE	Signaling events mediated by focal adhesion kinase	0.00007625090956182923	0.00007625090956182923	+1	PIK3CA,PIK3R1,ARHGAP35,MAP2K4,BRAF,CCND1
DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.3	DNA Double-Strand Break Repair	0.0000766836134228988	0.0000766836134228988	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,BRCA2,ATR,HIST1H2BD
HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030	Hypoxia response via HIF activation	0.00007905693886361306	0.00007905693886361306	+1	PTEN,VHL,AKT1,MTOR
BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY	BIOCARTA_ACH_PATHWAY	0.00007905693886361306	0.00007905693886361306	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 73%180292	GAB1 signalosome	0.00007905693886361306	0.00007905693886361306	+1	PIK3CA,EGFR,PIK3R1,PTPN11
TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 73%210993	Tie2 Signaling	0.00007905693886361306	0.00007905693886361306	+1	PIK3CA,PIK3R1,NRAS,PTPN11
MAMMARY GLAND DEVELOPMENT PATHWAY - EMBRYONIC DEVELOPMENT (STAGE 1 OF 4)%WIKIPATHWAYS_20200810%WP2813%HOMO SAPIENS	Mammary gland development pathway - Embryonic development (Stage 1 of 4)	0.00007905693886361306	0.00007905693886361306	+1	CDH1,AKT1,ERBB4,CCND1
ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY	ATM pathway	0.00007998403771004872	0.00007998403771004872	+1	ATM,BRCA1,CHEK2,SMC1A,SMC3
PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY	PID_ATM_PATHWAY	0.00007998403771004872	0.00007998403771004872	+1	ATM,BRCA1,CHEK2,SMC1A,SMC3
RESPONSE TO ESTROGEN%GOBP%GO:0043627	response to estrogen	0.00007998403771004872	0.00007998403771004872	+1	GATA3,CRIPAK,AR,BRCA1,EP300
PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY	PID_IL2_PI3K_PATHWAY	0.00007998403771004872	0.00007998403771004872	+1	PIK3CA,PIK3R1,AKT1,MTOR,PTPN11
PROTEIN LOCALIZATION TO CHROMOSOME%GOBP%GO:0034502	protein localization to chromosome	0.00008151729344736721	0.00008151729344736721	+1	RB1,CTCF,ATRX,BRCA2,ATR,RAD21
PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY	PID_FAK_PATHWAY	0.00008151729344736721	0.00008151729344736721	+1	PIK3CA,PIK3R1,ARHGAP35,MAP2K4,BRAF,CCND1
KITRECEPTOR%IOB%KITRECEPTOR	KitReceptor	0.0000874305926681213	0.0000874305926681213	+1	PIK3CA,PIK3R1,AKT1,MTOR,KIT,EP300,PTPN11
MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:0002009	morphogenesis of an epithelium	0.00008876562659885671	0.00008876562659885671	+1	GATA3,NOTCH1,CTNNB1,ARHGAP35,TBX3,SOX9,WT1,FGFR2,TGFBR2,SOX17
NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING	Neurotrophic factor-mediated Trk receptor signaling	0.00008876562659885671	0.00008876562659885671	+1	PIK3CA,KRAS,PIK3R1,NRAS,CCND1,PTPN11
COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY	Coregulation of Androgen receptor activity	0.00008876562659885671	0.00008876562659885671	+1	CDKN2A,CTNNB1,AKT1,AR,BRCA1,CCND1
FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS	Fc-epsilon receptor I signaling in mast cells	0.00008876562659885671	0.00008876562659885671	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PTPN11
TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 73%8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.00009069862018938835	0.00009069862018938835	+1	EGFR,NPM1,KIT,EP300,CDKN1A
REGULATION OF DNA BINDING%GOBP%GO:0051101	regulation of DNA binding	0.00009222907831505447	0.00009222907831505447	+1	GATA3,RB1,CTNNB1,EP300,TAF1,SIN3A,NSD1
TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052	TGF-beta signaling pathway	0.00009222907831505447	0.00009222907831505447	+1	NRAS,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056	VEGF signaling pathway	0.00009371378167322631	0.00009371378167322631	+1	PIK3CA,PIK3R1,NRAS,AKT1,BRAF,PIK3CG
BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY	BIOCARTA_IL7_PATHWAY	0.00009371378167322631	0.00009371378167322631	+1	PIK3CA,PIK3R1,PIK3CG,EP300
POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE%GOBP%GO:0070374	positive regulation of ERK1 and ERK2 cascade	0.00009371378167322631	0.00009371378167322631	+1	EGFR,NOTCH1,FBXW7,BRAF,ERBB4,PDGFRA,FGFR2,FGFR3,PTPN11
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 73%8934593	Regulation of RUNX1 Expression and Activity	0.00009371378167322631	0.00009371378167322631	+1	RUNX1,CCND1,CBFB,PTPN11
PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY	PID_FCER1_PATHWAY	0.00009371378167322631	0.00009371378167322631	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PTPN11
SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.1	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	0.00009371378167322631	0.00009371378167322631	+1	PIK3CA,PIK3R1,NRAS,KIT
SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 73%5655332	Signaling by FGFR3 in disease	0.00009371378167322631	0.00009371378167322631	+1	PIK3CA,PIK3R1,NRAS,FGFR3
SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME%R-HSA-5637815.1	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.00009371378167322631	0.00009371378167322631	+1	PIK3CA,EGFR,PIK3R1,NRAS
SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.2	Signaling by PDGFR in disease	0.00009371378167322631	0.00009371378167322631	+1	PIK3CA,PIK3R1,NRAS,PDGFRA
DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME DATABASE ID RELEASE 73%9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	0.00009371378167322631	0.00009371378167322631	+1	RB1,CDKN1B,CCND1,CDKN1A
MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20200810%WP4872%HOMO SAPIENS	MAP3K1 role in promoting and blocking gonadal determination	0.00009371378167322631	0.00009371378167322631	+1	CTNNB1,MAP3K1,SOX9,FGFR2
SIGNALING BY KIT IN DISEASE%REACTOME DATABASE ID RELEASE 73%9669938	Signaling by KIT in disease	0.00009371378167322631	0.00009371378167322631	+1	PIK3CA,PIK3R1,NRAS,KIT
MITOTIC DNA DAMAGE CHECKPOINT%GOBP%GO:0044773	mitotic DNA damage checkpoint	0.00009371378167322631	0.00009371378167322631	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.4	Pre-NOTCH Transcription and Translation	0.00009371378167322631	0.00009371378167322631	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS	Integrins in angiogenesis	0.00009371378167322631	0.00009371378167322631	+1	PIK3CA,PIK3R1,AKT1,CDKN1B,TGFBR2,PTPN11
SIGNALING BY FGFR3 POINT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 73%8853338	Signaling by FGFR3 point mutants in cancer	0.00009371378167322631	0.00009371378167322631	+1	PIK3CA,PIK3R1,NRAS,FGFR3
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.1	Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects	0.00009371378167322631	0.00009371378167322631	+1	RB1,CDKN1B,CCND1,CDKN1A
FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 73%9617828	FOXO-mediated transcription of cell cycle genes	0.00009371378167322631	0.00009371378167322631	+1	CDKN1B,SMAD4,CDKN1A,SMAD2
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.1	Regulation of TP53 Activity through Phosphorylation	0.00009371378167322631	0.00009371378167322631	+1	TP53,STK11,ATM,BRCA1,CHEK2,TAF1,ATR
CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.1	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.00009371378167322631	0.00009371378167322631	+1	PIK3CA,EGFR,PIK3R1,NRAS
PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY	PID_AR_PATHWAY	0.00009371378167322631	0.00009371378167322631	+1	CDKN2A,CTNNB1,AKT1,AR,BRCA1,CCND1
IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K	IL2 signaling events mediated by PI3K	0.00009693736961277193	0.00009693736961277193	+1	PIK3CA,PIK3R1,AKT1,MTOR,PTPN11
SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 73%166520	Signaling by NTRKs	0.00009693736961277193	0.00009693736961277193	+1	PIK3CA,PIK3R1,NRAS,BRAF,EP300,PPP2R1A,PTPN11,EGR3
RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.1	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	0.00009693736961277193	0.00009693736961277193	+1	ARID1A,PBRM1,RUNX1,EP300,CBFB
GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS	GMCSF-mediated signaling events	0.00009693736961277193	0.00009693736961277193	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
PATTERN SPECIFICATION PROCESS%GOBP%GO:0007389	pattern specification process	0.00009693736961277193	0.00009693736961277193	+1	APC,NOTCH1,TBX3,WT1,ERBB4,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
NEGATIVE REGULATION OF MAPK CASCADE%GOBP%GO:0043409	negative regulation of MAPK cascade	0.00009693736961277193	0.00009693736961277193	+1	PTEN,NF1,TLR4,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY	PID_TRKR_PATHWAY	0.00009889732660389268	0.00009889732660389268	+1	PIK3CA,KRAS,PIK3R1,NRAS,CCND1,PTPN11
REGULATION OF CELLULAR RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1900407	regulation of cellular response to oxidative stress	0.00009889732660389268	0.00009889732660389268	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
POSITIVE REGULATION OF CELL-CELL ADHESION%GOBP%GO:0022409	positive regulation of cell-cell adhesion	0.00009911716621375276	0.00009911716621375276	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 73%5689880	Ub-specific processing proteases	0.00009911716621375276	0.00009911716621375276	+1	TP53,PTEN,GATA3,KEAP1,AR,SMAD4,USP9X,HIST1H2BD,SMAD2,AXIN2
REGULATION OF UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:2000058	regulation of ubiquitin-dependent protein catabolic process	0.000105832864913257	0.000105832864913257	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
EMBRYONIC ORGAN MORPHOGENESIS%GOBP%GO:0048562	embryonic organ morphogenesis	0.000105832864913257	0.000105832864913257	+1	NOTCH1,CTNNB1,TBX3,SOX9,PDGFRA,FGFR2,TGFBR2,SOX17
POSITIVE REGULATION OF ACTIVIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0032927	positive regulation of activin receptor signaling pathway	0.00010610639378261237	0.00010610639378261237	+1	ACVR1B,ACVR2A,SMAD2
LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.2	Loss of Function of SMAD2 3 in Cancer	0.00010610639378261237	0.00010610639378261237	+1	SMAD4,TGFBR2,SMAD2
APOPTOTIC SIGNALING PATHWAY%GOBP%GO:0097190	apoptotic signaling pathway	0.00010610639378261237	0.00010610639378261237	+1	TP53,STK11,ATM,TLR4,BRCA1,CHEK2,EP300,FGFR3,CDKN1A,ACVR1B
SOMATROPH AXIS (GH) AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20200810%WP4186%HOMO SAPIENS	Somatroph axis (GH) and its relationship to dietary restriction and aging	0.00010610639378261237	0.00010610639378261237	+1	PTEN,AKT1,MTOR
ENDOCARDIAL CELL DIFFERENTIATION%GOBP%GO:0060956	endocardial cell differentiation	0.00010610639378261237	0.00010610639378261237	+1	NOTCH1,SMAD4,SOX17
CARDIAC ENDOTHELIAL CELL DIFFERENTIATION%GOBP%GO:0003348	cardiac endothelial cell differentiation	0.00010610639378261237	0.00010610639378261237	+1	NOTCH1,SMAD4,SOX17
REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY%GOBP%GO:0043551	regulation of phosphatidylinositol 3-kinase activity	0.0001067665649125613	0.0001067665649125613	+1	PIK3R1,FLT3,KIT,PDGFRA,FGFR3
PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY	PID_GMCSF_PATHWAY	0.0001067665649125613	0.0001067665649125613	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
REGULATION OF ORGAN GROWTH%GOBP%GO:0046620	regulation of organ growth	0.0001067665649125613	0.0001067665649125613	+1	PTEN,NOTCH1,WT1,ERBB4,FGFR2
EMBRYONIC PATTERN SPECIFICATION%GOBP%GO:0009880	embryonic pattern specification	0.0001067665649125613	0.0001067665649125613	+1	TBX3,WT1,ERBB4,FGFR2,SMAD2
FACTORS AND PATHWAYS AFFECTING INSULIN-LIKE GROWTH FACTOR (IGF1)-AKT SIGNALING%WIKIPATHWAYS_20200810%WP3850%HOMO SAPIENS	Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling	0.0001067665649125613	0.0001067665649125613	+1	PTEN,AKT1,PIK3CG,MTOR,SMAD2
BLOOD VESSEL MORPHOGENESIS%GOBP%GO:0048514	blood vessel morphogenesis	0.00010775720655986802	0.00010775720655986802	+1	NF1,NOTCH1,CTNNB1,AKT1,WT1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-HSA-5654708.1	Downstream signaling of activated FGFR3	0.00011162675681804452	0.00011162675681804452	+1	PIK3CA,PIK3R1,NRAS,PTPN11
TGF-B SIGNALING IN THYROID CELLS FOR EPITHELIAL-MESENCHYMAL TRANSITION%WIKIPATHWAYS_20200810%WP3859%HOMO SAPIENS	TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition	0.00011162675681804452	0.00011162675681804452	+1	CDH1,AKT1,SMAD4,SMAD2
BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY	BIOCARTA_ERK5_PATHWAY	0.00011162675681804452	0.00011162675681804452	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK	Validated nuclear estrogen receptor alpha network	0.00011308574470030769	0.00011308574470030769	+1	BRCA1,EP300,CCND1,SMAD4,NCOR1,AXIN2
PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY	PID_ERA_GENOMIC_PATHWAY	0.00011308574470030769	0.00011308574470030769	+1	BRCA1,EP300,CCND1,SMAD4,NCOR1,AXIN2
VENTRICULAR SEPTUM DEVELOPMENT%GOBP%GO:0003281	ventricular septum development	0.00011927353616034149	0.00011927353616034149	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 73%1433557	Signaling by SCF-KIT	0.00011927353616034149	0.00011927353616034149	+1	PIK3CA,PIK3R1,NRAS,KIT,PTPN11
BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY	BIOCARTA_FCER1_PATHWAY	0.00011927353616034149	0.00011927353616034149	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,PIK3CG
INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1	Internalization of ErbB1	0.00011927353616034149	0.00011927353616034149	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 73%6796648	TP53 Regulates Transcription of DNA Repair Genes	0.00012175420300426245	0.00012175420300426245	+1	TP53,ATM,BRCA1,ATR,CDK12,ERCC2
SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 73%5654738	Signaling by FGFR2	0.00012175420300426245	0.00012175420300426245	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
LEPTIN%NETPATH%LEPTIN	Leptin	0.00012175420300426245	0.00012175420300426245	+1	PTEN,EGFR,PIK3R1,AKT1,MTOR,EP300,PTPN11
KIDNEY DEVELOPMENT%GOBP%GO:0001822	kidney development	0.00012352692325988342	0.00012352692325988342	+1	NF1,GATA3,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
CHROMATIN ASSEMBLY%GOBP%GO:0031497	chromatin assembly	0.00012352692325988342	0.00012352692325988342	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD
PROTEIN-DNA COMPLEX SUBUNIT ORGANIZATION%GOBP%GO:0071824	protein-DNA complex subunit organization	0.00012609335267057628	0.00012609335267057628	+1	ARID1A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,SETD2,TAF1,HIST1H2BD,ERCC2
P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69580.3	p53-Dependent G1 S DNA damage checkpoint	0.00013122744548377003	0.00013122744548377003	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 73%69563	p53-Dependent G1 DNA Damage Response	0.00013122744548377003	0.00013122744548377003	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.3	Costimulation by the CD28 family	0.00013122744548377003	0.00013122744548377003	+1	PIK3CA,PIK3R1,AKT1,MTOR,PPP2R1A,PTPN11
SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP	Signaling events mediated by TCPTP	0.00013218944255653618	0.00013218944255653618	+1	PIK3CA,EGFR,PIK3R1,HGF,ATR
IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 73%112399	IRS-mediated signalling	0.00013218944255653618	0.00013218944255653618	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20200810%WP1545%HOMO SAPIENS	miRNAs involved in DNA damage response	0.00013218944255653618	0.00013218944255653618	+1	TP53,ATM,CDKN1B,CCND1,CDKN1A
BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY	BIOCARTA_GCR_PATHWAY	0.00013406153666083715	0.00013406153666083715	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.1	Regulation of TP53 Activity through Methylation	0.00013406153666083715	0.00013406153666083715	+1	TP53,ATM,CHEK2,EP300
CELLULAR RESPONSE TO RADIATION%GOBP%GO:0071478	cellular response to radiation	0.00013410239059675802	0.00013410239059675802	+1	TP53,NPM1,STK11,ATM,EP300,CDKN1A,TAF1,ATR
MITOTIC DNA INTEGRITY CHECKPOINT%GOBP%GO:0044774	mitotic DNA integrity checkpoint	0.00013410239059675802	0.00013410239059675802	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
CELLULAR RESPONSE TO LIGHT STIMULUS%GOBP%GO:0071482	cellular response to light stimulus	0.00013410239059675802	0.00013410239059675802	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-HSA-9006936.5	Signaling by TGFB family members	0.00014252439816204882	0.00014252439816204882	+1	SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,NCOR1,SMAD2
RESPONSE TO MECHANICAL STIMULUS%GOBP%GO:0009612	response to mechanical stimulus	0.00014252439816204882	0.00014252439816204882	+1	PIK3CA,CTNNB1,MAP3K1,MAP2K4,SOX9,TLR4,KIT
IL-5 SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP127%HOMO SAPIENS	IL-5 Signaling Pathway	0.00014674319904849187	0.00014674319904849187	+1	KRAS,PIK3R1,AKT1,PIK3CG,PTPN11
PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING	Plasma membrane estrogen receptor signaling	0.00014674319904849187	0.00014674319904849187	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1
KISSPEPTIN/KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20200810%WP4871%HOMO SAPIENS	Kisspeptin/Kisspeptin Receptor System in the Ovary	0.00014674319904849187	0.00014674319904849187	+1	PIK3CA,KRAS,NRAS,AKT1,PIK3CG
SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2	Signaling events mediated by VEGFR1 and VEGFR2	0.00015015162140769655	0.00015015162140769655	+1	PIK3CA,PIK3R1,CTNNB1,AKT1,BRAF,PTPN11
NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20200810%WP2064%HOMO SAPIENS	Neural Crest Differentiation	0.00015015162140769655	0.00015015162140769655	+1	NOTCH1,CTNNB1,CDH1,SOX9,FGFR2,FGFR3,AXIN2
PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY	PID_CXCR4_PATHWAY	0.00015015162140769655	0.00015015162140769655	+1	PIK3CA,PTEN,PIK3R1,AKT1,PIK3CG,MTOR,PTPN11
G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.2	G1 S DNA Damage Checkpoints	0.00015015162140769655	0.00015015162140769655	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
RENAL SYSTEM DEVELOPMENT%GOBP%GO:0072001	renal system development	0.00015265251785486218	0.00015265251785486218	+1	NF1,GATA3,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS%GOBP%GO:0045732	positive regulation of protein catabolic process	0.00015539632826557594	0.00015539632826557594	+1	PTEN,APC,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,LRRK2,TAF1
STEM CELL DIFFERENTIATION%GOBP%GO:0048863	stem cell differentiation	0.00015814432634590438	0.00015814432634590438	+1	TP53,NOTCH1,SOX9,ERBB4,KIT,SETD2,FGFR2
POSITIVE REGULATION OF PROTEOLYSIS INVOLVED IN CELLULAR PROTEIN CATABOLIC PROCESS%GOBP%GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process	0.00015814432634590438	0.00015814432634590438	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
POSITIVE REGULATION OF ORGAN GROWTH%GOBP%GO:0046622	positive regulation of organ growth	0.00015957894173814665	0.00015957894173814665	+1	NOTCH1,WT1,ERBB4,FGFR2
SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 73%1181150	Signaling by NODAL	0.00015957894173814665	0.00015957894173814665	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
POSITIVE REGULATION OF HEART GROWTH%GOBP%GO:0060421	positive regulation of heart growth	0.00015957894173814665	0.00015957894173814665	+1	NOTCH1,WT1,ERBB4,FGFR2
PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY	PID_VEGFR1_2_PATHWAY	0.0001598332903639048	0.0001598332903639048	+1	PIK3CA,PIK3R1,CTNNB1,AKT1,BRAF,PTPN11
REGULATION OF RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1902882	regulation of response to oxidative stress	0.0001598332903639048	0.0001598332903639048	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
STEM CELL POPULATION MAINTENANCE%GOBP%GO:0019827	stem cell population maintenance	0.0001598332903639048	0.0001598332903639048	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY	PID_ERBB1_INTERNALIZATION_PATHWAY	0.00016028491935133528	0.00016028491935133528	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY	PID_ER_NONGENOMIC_PATHWAY	0.00016028491935133528	0.00016028491935133528	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1
RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-HSA-8941855.1	RUNX3 regulates CDKN1A transcription	0.00016251613641207936	0.00016251613641207936	+1	TP53,SMAD4,CDKN1A
SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 73%3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.00016251613641207936	0.00016251613641207936	+1	SMAD4,TGFBR2,SMAD2
KITRECEPTOR%NETPATH%KITRECEPTOR	KitReceptor	0.00016445648591917146	0.00016445648591917146	+1	PIK3CA,PIK3R1,AKT1,MTOR,KIT,EP300,PTPN11
MAINTENANCE OF CELL NUMBER%GOBP%GO:0098727	maintenance of cell number	0.00017146523307014447	0.00017146523307014447	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
HALLMARK_UV_RESPONSE_DN%MSIGDB_C2%HALLMARK_UV_RESPONSE_DN	HALLMARK_UV_RESPONSE_DN	0.00017161196865051717	0.00017161196865051717	+1	PTEN,RUNX1,CDKN1B,ATRX,KIT,TGFBR2,ACVR2A,SPOP
HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDB_C2%HALLMARK_PI3K_AKT_MTOR_SIGNALING	HALLMARK_PI3K_AKT_MTOR_SIGNALING	0.00017395563713129236	0.00017395563713129236	+1	PTEN,EGFR,AKT1,CDKN1B,CDKN1A,PTPN11,SMAD2
DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-HSA-3769402.3	Deactivation of the beta-catenin transactivating complex	0.00017810238532083245	0.00017810238532083245	+1	APC,CTNNB1,AKT1,SOX9,SOX17
GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959	Gastrin_CCK2R_240212	0.0001784729721636328	0.0001784729721636328	+1	PTEN,PIK3R1,CTNNB1,CDH1,MAP2K4,AKT1,BRAF,PTPN11
POSITIVE REGULATION OF PEPTIDYL-TYROSINE PHOSPHORYLATION%GOBP%GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	0.0001784729721636328	0.0001784729721636328	+1	TP53,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PTPN11
EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.2	Epigenetic regulation of gene expression	0.0001784729721636328	0.0001784729721636328	+1	DNMT3A,TET2,EP300,SF3B1,SIN3A,HIST1H2BD,ERCC2,EZH2
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.2	SUMOylation of DNA damage response and repair proteins	0.00018294885042922376	0.00018294885042922376	+1	CDKN2A,STAG2,BRCA1,SMC1A,SMC3,RAD21
DNA-TEMPLATED TRANSCRIPTION, INITIATION%GOBP%GO:0006352	DNA-templated transcription, initiation	0.00018294885042922376	0.00018294885042922376	+1	PTEN,NOTCH1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY	BIOCARTA_IGF1_PATHWAY	0.00018725597590464477	0.00018725597590464477	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 73%9006115	Signaling by NTRK2 (TRKB)	0.00018725597590464477	0.00018725597590464477	+1	PIK3CA,PIK3R1,NRAS,PTPN11
TP53 NETWORK%WIKIPATHWAYS_20200810%WP1742%HOMO SAPIENS	TP53 Network	0.00018725597590464477	0.00018725597590464477	+1	TP53,CDKN2A,ATM,CDKN1A
SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.1	Signaling by ERBB2 KD Mutants	0.00018725597590464477	0.00018725597590464477	+1	PIK3CA,EGFR,PIK3R1,NRAS
MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-HSA-453279.4	Mitotic G1 phase and G1 S transition	0.0001940883913443961	0.0001940883913443961	+1	CDKN2A,RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
IGF1R SIGNALING CASCADE%REACTOME%R-HSA-2428924.1	IGF1R signaling cascade	0.00019443583917494364	0.00019443583917494364	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY	PID_TCPTP_PATHWAY	0.00019443583917494364	0.00019443583917494364	+1	PIK3CA,EGFR,PIK3R1,HGF,ATR
IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.1	IRS-related events triggered by IGF1R	0.00019443583917494364	0.00019443583917494364	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048	PI3 kinase pathway	0.00019443583917494364	0.00019443583917494364	+1	PIK3CA,PTEN,PIK3R1,NRAS,AKT1
REGULATION OF MYELOID CELL DIFFERENTIATION%GOBP%GO:0045637	regulation of myeloid cell differentiation	0.00020205838389221348	0.00020205838389221348	+1	FBXW7,RUNX1,MTOR,TLR4,EP300,CBFB,SIN3A,ACVR1B,ACVR2A
RESPONSE TO HYPOXIA%GOBP%GO:0001666	response to hypoxia	0.00020205838389221348	0.00020205838389221348	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
IL4%NETPATH%IL4	IL4	0.00020938996365364975	0.00020938996365364975	+1	PIK3CA,PIK3R1,CEBPA,AKT1,EP300,PTPN11
PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%R-HSA-1912422.1	Pre-NOTCH Expression and Processing	0.00021327845087927176	0.00021327845087927176	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
CELL FATE SPECIFICATION%GOBP%GO:0001708	cell fate specification	0.0002139909058424983	0.0002139909058424983	+1	APC,TBX3,SOX9,FOXA2,SOX17
A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING	a6b1 and a6b4 Integrin signaling	0.0002139909058424983	0.0002139909058424983	+1	PIK3CA,EGFR,PIK3R1,CDH1,AKT1
BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY	BIOCARTA_TCR_PATHWAY	0.0002139909058424983	0.0002139909058424983	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,PIK3CG
FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS	FOXA2 and FOXA3 transcription factor networks	0.0002139909058424983	0.0002139909058424983	+1	NF1,CEBPA,AKT1,FOXA1,FOXA2
SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.2	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.0002139909058424983	0.0002139909058424983	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-HSA-5654716.1	Downstream signaling of activated FGFR4	0.0002169593097399421	0.0002169593097399421	+1	PIK3CA,PIK3R1,NRAS,PTPN11
POSITIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING%GOBP%GO:2000679	positive regulation of transcription regulatory region DNA binding	0.0002169593097399421	0.0002169593097399421	+1	GATA3,RB1,CTNNB1,EP300
REGULATION OF TRANSCRIPTION BY RNA POLYMERASE III%GOBP%GO:0006359	regulation of transcription by RNA polymerase III	0.0002169593097399421	0.0002169593097399421	+1	CEBPA,AR,MTOR,BRCA1
POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN CELLULAR RESPONSE TO CHEMICAL STIMULUS%GOBP%GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	0.0002169593097399421	0.0002169593097399421	+1	NOTCH1,NFE2L2,EP300,SMAD4
BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY	BIOCARTA_AKT_PATHWAY	0.0002169593097399421	0.0002169593097399421	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY	BIOCARTA_INSULIN_PATHWAY	0.0002169593097399421	0.0002169593097399421	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-HSA-389357.1	CD28 dependent PI3K Akt signaling	0.0002169593097399421	0.0002169593097399421	+1	PIK3CA,PIK3R1,AKT1,MTOR
FGF23 SIGNALLING IN HYPOPHOSPHATEMIC RICKETS%WIKIPATHWAYS_20200810%WP4790%HOMO SAPIENS	FGF23 signalling in Hypophosphatemic rickets	0.0002169593097399421	0.0002169593097399421	+1	FGFR2,CCND1,FGFR3,CDKN1A
SIGNALING BY ERBB2 IN CANCER%REACTOME%R-HSA-1227990.3	Signaling by ERBB2 in Cancer	0.0002169593097399421	0.0002169593097399421	+1	PIK3CA,EGFR,PIK3R1,NRAS
RESPONSE TO DECREASED OXYGEN LEVELS%GOBP%GO:0036293	response to decreased oxygen levels	0.00022025487071922596	0.00022025487071922596	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
UROGENITAL SYSTEM DEVELOPMENT%GOBP%GO:0001655	urogenital system development	0.00022405085494591148	0.00022405085494591148	+1	NF1,GATA3,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 73%74751	Insulin receptor signalling cascade	0.00023165472536931109	0.00023165472536931109	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY	PID_HNF3B_PATHWAY	0.00023165472536931109	0.00023165472536931109	+1	NF1,CEBPA,AKT1,FOXA1,FOXA2
INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-HSA-6785807.5	Interleukin-4 and Interleukin-13 signaling	0.00023165472536931109	0.00023165472536931109	+1	TP53,PIK3R1,GATA3,AKT1,HGF,CCND1,CDKN1A
SIG_CHEMOTAXIS%MSIGDB_C2%SIG_CHEMOTAXIS	SIG_CHEMOTAXIS	0.00023165472536931109	0.00023165472536931109	+1	PIK3CA,PTEN,PIK3R1,AKT1,PIK3CG
REGULATION OF HISTONE METHYLATION%GOBP%GO:0031060	regulation of histone methylation	0.00023165472536931109	0.00023165472536931109	+1	CTNNB1,ATRX,BRCA1,SMAD4,NSD1
HALLMARK_P53_PATHWAY%MSIGDB_C2%HALLMARK_P53_PATHWAY	HALLMARK_P53_PATHWAY	0.00023316340445922023	0.00023316340445922023	+1	TP53,CDKN2A,RB1,NOTCH1,FBXW7,CEBPA,HIST1H1C,CDKN1A,ACVR1B
ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR	AndrogenReceptor	0.00023316340445922023	0.00023316340445922023	+1	PIK3R1,AKT1,AR
CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20200810%WP4191%HOMO SAPIENS	Caloric restriction and aging	0.00023316340445922023	0.00023316340445922023	+1	TP53,AKT1,MTOR
POSITIVE REGULATION OF MAP KINASE ACTIVITY%GOBP%GO:0043406	positive regulation of MAP kinase activity	0.00023316340445922023	0.00023316340445922023	+1	EGFR,FLT3,MAP2K4,BRAF,PIK3CG,TLR4,LRRK2,KIT,EZH2
ENDOCARDIUM DEVELOPMENT%GOBP%GO:0003157	endocardium development	0.00023316340445922023	0.00023316340445922023	+1	NOTCH1,SMAD4,SOX17
PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY	PID_AVB3_INTEGRIN_PATHWAY	0.00023316340445922023	0.00023316340445922023	+1	PIK3CA,PIK3R1,AKT1,CDKN1B,TGFBR2,PTPN11
SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.2	Signaling by NTRK1 (TRKA)	0.00024046002743806897	0.00024046002743806897	+1	PIK3CA,PIK3R1,NRAS,BRAF,EP300,PPP2R1A,EGR3
HEART MORPHOGENESIS%GOBP%GO:0003007	heart morphogenesis	0.00024469286460162014	0.00024469286460162014	+1	GATA3,NOTCH1,TBX3,SOX9,FGFR2,SMAD4,TGFBR2,SOX17
SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.7	Signaling by ERBB2	0.00024469286460162014	0.00024469286460162014	+1	PIK3CA,EGFR,PIK3R1,NRAS,AKT1
FLK2 FLT3%IOB%FLK2 FLT3	FLK2 FLT3	0.00024469286460162014	0.00024469286460162014	+1	FLT3,CEBPA,AKT1,PTPN11
CELLULAR RESPONSE TO DRUG%GOBP%GO:0035690	cellular response to drug	0.00024469286460162014	0.00024469286460162014	+1	TP53,CTNNB1,CDH1,NFE2L2,SOX9,ATRX,BRCA1,LRRK2,TAF1
REGULATION OF JAK-STAT CASCADE%GOBP%GO:0046425	regulation of JAK-STAT cascade	0.00024469286460162014	0.00024469286460162014	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION%GOBP%GO:1901989	positive regulation of cell cycle phase transition	0.00024469286460162014	0.00024469286460162014	+1	EGFR,RB1,NPM1,AKT1,CCND1,EZH2
SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 73%190236	Signaling by FGFR	0.00024469286460162014	0.00024469286460162014	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
NEGATIVE REGULATION OF FATTY ACID METABOLIC PROCESS%GOBP%GO:0045922	negative regulation of fatty acid metabolic process	0.00024469286460162014	0.00024469286460162014	+1	AKT1,SOX9,BRCA1,NCOR1
DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.1	Downregulation of SMAD2 3:SMAD4 transcriptional activity	0.00024469286460162014	0.00024469286460162014	+1	SMAD4,USP9X,NCOR1,SMAD2
HEART DEVELOPMENT%WIKIPATHWAYS_20200810%WP1591%HOMO SAPIENS	Heart Development	0.00024469286460162014	0.00024469286460162014	+1	NOTCH1,CTNNB1,SMAD4,FOXA2,PTPN11
PROLACTIN SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP2037%HOMO SAPIENS	Prolactin Signaling Pathway	0.00024469286460162014	0.00024469286460162014	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,MTOR,PTPN11
PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY	PID_A6B1_A6B4_INTEGRIN_PATHWAY	0.00024469286460162014	0.00024469286460162014	+1	PIK3CA,EGFR,PIK3R1,CDH1,AKT1
LEPTIN SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP2034%HOMO SAPIENS	Leptin signaling pathway	0.00024469286460162014	0.00024469286460162014	+1	PTEN,PIK3R1,AKT1,MTOR,CCND1,PTPN11
G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:0000082	G1/S transition of mitotic cell cycle	0.00024469286460162014	0.00024469286460162014	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,ACVR1B,CDKN2C
REGULATION OF FIBROBLAST PROLIFERATION%GOBP%GO:0048145	regulation of fibroblast proliferation	0.00024469286460162014	0.00024469286460162014	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 73%5654687	Downstream signaling of activated FGFR1	0.00024469286460162014	0.00024469286460162014	+1	PIK3CA,PIK3R1,NRAS,PTPN11
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 73%5654696	Downstream signaling of activated FGFR2	0.00024469286460162014	0.00024469286460162014	+1	PIK3CA,PIK3R1,NRAS,PTPN11
SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 73%9006335	Signaling by Erythropoietin	0.00024469286460162014	0.00024469286460162014	+1	PIK3CA,PIK3R1,NRAS,PIK3CG
BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY	BIOCARTA_RAS_PATHWAY	0.00024469286460162014	0.00024469286460162014	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 73%5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.00024469286460162014	0.00024469286460162014	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 73%1643713	Signaling by EGFR in Cancer	0.00024469286460162014	0.00024469286460162014	+1	PIK3CA,EGFR,PIK3R1,NRAS
GONAD DEVELOPMENT%GOBP%GO:0008406	gonad development	0.00025619406726874446	0.00025619406726874446	+1	GATA3,AR,SOX9,WT1,KIT,PDGFRA
NEGATIVE REGULATION OF SMALL MOLECULE METABOLIC PROCESS%GOBP%GO:0062014	negative regulation of small molecule metabolic process	0.00025619406726874446	0.00025619406726874446	+1	TP53,AKT1,SOX9,BRCA1,EP300,NCOR1
DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.1	DNA Double Strand Break Response	0.00025619406726874446	0.00025619406726874446	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY	PID_IL6_7_PATHWAY	0.00026960793045968895	0.00026960793045968895	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PTPN11
IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS	IL6-mediated signaling events	0.00026960793045968895	0.00026960793045968895	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PTPN11
INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:0097193	intrinsic apoptotic signaling pathway	0.00027048627642408453	0.00027048627642408453	+1	TP53,STK11,ATM,BRCA1,CHEK2,EP300,CDKN1A
CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:0044843	cell cycle G1/S phase transition	0.00027048627642408453	0.00027048627642408453	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,ACVR1B,CDKN2C
NUCLEOSOME ORGANIZATION%GOBP%GO:0034728	nucleosome organization	0.00027352504616321924	0.00027352504616321924	+1	ARID1A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,SETD2,HIST1H2BD
ANGIOGENESIS%WIKIPATHWAYS_20200810%WP1539%HOMO SAPIENS	Angiogenesis	0.0002855260215115687	0.0002855260215115687	+1	PIK3CA,AKT1,PDGFRA,FGFR2
ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.1	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	0.0002855260215115687	0.0002855260215115687	+1	EGFR,AKT1,CDKN1B,CCND1
CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION%GOBP%GO:0021953	central nervous system neuron differentiation	0.0002917034258689323	0.0002917034258689323	+1	PTEN,CTNNB1,ARHGAP35,ERBB4,FGFR2,SIN3A
DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS%GOBP%GO:0045137	development of primary sexual characteristics	0.0002917034258689323	0.0002917034258689323	+1	GATA3,AR,SOX9,WT1,KIT,PDGFRA
SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 73%177929	Signaling by EGFR	0.0002941759380918925	0.0002941759380918925	+1	PIK3CA,EGFR,PIK3R1,NRAS,PTPN11
MALE GONAD DEVELOPMENT%GOBP%GO:0008584	male gonad development	0.0002941759380918925	0.0002941759380918925	+1	GATA3,AR,SOX9,WT1,KIT
REGULATION OF STAT CASCADE%GOBP%GO:1904892	regulation of STAT cascade	0.00029789153779523537	0.00029789153779523537	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
RESPONSE TO OXYGEN LEVELS%GOBP%GO:0070482	response to oxygen levels	0.0003180382066851043	0.0003180382066851043	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.1	Signaling by FGFR4 in disease	0.00032031041528441984	0.00032031041528441984	+1	PIK3CA,PIK3R1,NRAS
DEVELOPMENT OF PRIMARY MALE SEXUAL CHARACTERISTICS%GOBP%GO:0046546	development of primary male sexual characteristics	0.00032031041528441984	0.00032031041528441984	+1	GATA3,AR,SOX9,WT1,KIT
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 73%6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.00032031041528441984	0.00032031041528441984	+1	TP53,NPM1,CDKN1B,EP300,CDKN1A
REGULATION OF RNA POLYMERASE II REGULATORY REGION SEQUENCE-SPECIFIC DNA BINDING%GOBP%GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	0.00032031041528441984	0.00032031041528441984	+1	EP300,TAF1,NSD1
SIGNALING BY PDGF%REACTOME%R-HSA-186797.4	Signaling by PDGF	0.00032031041528441984	0.00032031041528441984	+1	PIK3CA,PIK3R1,NRAS,PDGFRA,PTPN11
CYTOSINE METHYLATION%WIKIPATHWAYS_20200810%WP3585%HOMO SAPIENS	Cytosine methylation	0.00032031041528441984	0.00032031041528441984	+1	IDH1,TET2,IDH2
ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING	Angiopoietin receptor Tie2-mediated signaling	0.00032031041528441984	0.00032031041528441984	+1	PIK3CA,PIK3R1,AKT1,CDKN1A,PTPN11
IL2%NETPATH%IL2	IL2	0.0003252684245750924	0.0003252684245750924	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,MTOR,PTPN11
SPINAL CORD INJURY%WIKIPATHWAYS_20200810%WP2431%HOMO SAPIENS	Spinal Cord Injury	0.0003252684245750924	0.0003252684245750924	+1	TP53,EGFR,RB1,SOX9,CDKN1B,TLR4,CCND1
NEGATIVE REGULATION OF CYTOSKELETON ORGANIZATION%GOBP%GO:0051494	negative regulation of cytoskeleton organization	0.0003252684245750924	0.0003252684245750924	+1	PIK3CA,APC,NAV3,PIK3R1,NPM1,BRCA1,SMAD4
VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM	VEGFR3 signaling in lymphatic endothelium	0.0003252684245750924	0.0003252684245750924	+1	PIK3CA,PIK3R1,MAP2K4,AKT1
TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY	TRAIL signaling pathway	0.0003252684245750924	0.0003252684245750924	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4
IL-7 SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP205%HOMO SAPIENS	IL-7 Signaling Pathway	0.0003252684245750924	0.0003252684245750924	+1	PIK3R1,AKT1,CDKN1B,CCND1
REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE%GOBP%GO:0060688	regulation of morphogenesis of a branching structure	0.0003252684245750924	0.0003252684245750924	+1	SOX9,HGF,LRRK2,FGFR2
PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY	PID_LYMPH_ANGIOGENESIS_PATHWAY	0.0003252684245750924	0.0003252684245750924	+1	PIK3CA,PIK3R1,MAP2K4,AKT1
DEVELOPMENTAL GROWTH%GOBP%GO:0048589	developmental growth	0.0003400027092383135	0.0003400027092383135	+1	NOTCH1,CTNNB1,SOX9,ERBB4,FGFR2,USP9X,FGFR3
MORPHOGENESIS OF A BRANCHING EPITHELIUM%GOBP%GO:0061138	morphogenesis of a branching epithelium	0.0003450039842320261	0.0003450039842320261	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
REGULATION OF NOTCH SIGNALING PATHWAY%GOBP%GO:0008593	regulation of Notch signaling pathway	0.0003450039842320261	0.0003450039842320261	+1	EGFR,NOTCH1,FBXW7,AKT1,ELF3,EP300
TSH%NETPATH%TSH	TSH	0.0003450039842320261	0.0003450039842320261	+1	PIK3CA,PIK3R1,RB1,AKT1,CDKN1B,MTOR
LEPTIN%IOB%LEPTIN	Leptin	0.0003450039842320261	0.0003450039842320261	+1	PTEN,EGFR,PIK3R1,AKT1,PTPN11
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY	PID_ANGIOPOIETIN_RECEPTOR_PATHWAY	0.0003450039842320261	0.0003450039842320261	+1	PIK3CA,PIK3R1,AKT1,CDKN1A,PTPN11
GROWTH%GOBP%GO:0040007	growth	0.00035482081647731246	0.00035482081647731246	+1	NOTCH1,CTNNB1,SOX9,ERBB4,FGFR2,USP9X,FGFR3
CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS	CXCR4-mediated signaling events	0.0003673729956944626	0.0003673729956944626	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,MTOR,PTPN11
NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION%GOBP%GO:0050680	negative regulation of epithelial cell proliferation	0.0003673729956944626	0.0003673729956944626	+1	NF1,GATA3,FBXW7,SOX9,FGFR2,BRCA2
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME DATABASE ID RELEASE 73%5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.00037143169445723865	0.00037143169445723865	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.3	Activation of HOX genes during differentiation	0.00037143169445723865	0.00037143169445723865	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
NEGATIVE REGULATION OF MACROAUTOPHAGY%GOBP%GO:0016242	negative regulation of macroautophagy	0.00037154902797383407	0.00037154902797383407	+1	PIK3CA,AKT1,MTOR,LRRK2
PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY	PID_VEGFR1_PATHWAY	0.00037154902797383407	0.00037154902797383407	+1	PIK3CA,PIK3R1,AKT1,PTPN11
MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20200810%WP4842%HOMO SAPIENS	Mammalian disorder of sexual development	0.00037154902797383407	0.00037154902797383407	+1	CTNNB1,SOX9,WT1,FGFR2
BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY	BIOCARTA_WNT_PATHWAY	0.00037154902797383407	0.00037154902797383407	+1	APC,CTNNB1,CCND1,SMAD4
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.1	Constitutive Signaling by AKT1 E17K in Cancer	0.00037154902797383407	0.00037154902797383407	+1	AKT1,CDKN1B,MTOR,CDKN1A
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES%MSIGDB_C2%SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	0.00037294150242430735	0.00037294150242430735	+1	PIK3CA,PTEN,PIK3R1,CDKN2A,AKT1
POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS%GOBP%GO:1903364	positive regulation of cellular protein catabolic process	0.0003866367331087579	0.0003866367331087579	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
POSITIVE REGULATION OF T CELL ACTIVATION%GOBP%GO:0050870	positive regulation of T cell activation	0.000393217791822391	0.000393217791822391	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
REGULATION OF WOUND HEALING%GOBP%GO:0061041	regulation of wound healing	0.0004057836238037619	0.0004057836238037619	+1	PTEN,CDKN1B,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A
INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE%GOBP%GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	0.00040588569761107127	0.00040588569761107127	+1	TP53,ATM,BRCA1,CHEK2,EP300
OUTFLOW TRACT MORPHOGENESIS%GOBP%GO:0003151	outflow tract morphogenesis	0.00040588569761107127	0.00040588569761107127	+1	NOTCH1,FGFR2,SMAD4,TGFBR2,SOX17
EPO%IOB%EPO	EPO	0.00040588569761107127	0.00040588569761107127	+1	PIK3R1,AKT1,BRAF,MTOR,PTPN11
ORGAN GROWTH%GOBP%GO:0035265	organ growth	0.0004233361891707197	0.0004233361891707197	+1	NOTCH1,SOX9,FGFR2,FGFR3
PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 73%9005895	Pervasive developmental disorders	0.0004233361891707197	0.0004233361891707197	+1	SIN3A,TBL1XR1,NCOR1
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 73%9005891	Loss of function of MECP2 in Rett syndrome	0.0004233361891707197	0.0004233361891707197	+1	SIN3A,TBL1XR1,NCOR1
VENTRICULAR SEPTUM MORPHOGENESIS%GOBP%GO:0060412	ventricular septum morphogenesis	0.0004233361891707197	0.0004233361891707197	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047	PDGF signaling pathway	0.0004233361891707197	0.0004233361891707197	+1	PIK3CA,PIK3R1,NRAS,BRAF,PIK3CG,ELF3,PDGFRA
AORTIC VALVE MORPHOGENESIS%GOBP%GO:0003180	aortic valve morphogenesis	0.0004233361891707197	0.0004233361891707197	+1	GATA3,RB1,NOTCH1,SOX9
REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS%GOBP%GO:2000136	regulation of cell proliferation involved in heart morphogenesis	0.0004233361891707197	0.0004233361891707197	+1	NOTCH1,CTNNB1,SMAD4
POSITIVE REGULATION OF TRANSCRIPTION BY RNA POLYMERASE III%GOBP%GO:0045945	positive regulation of transcription by RNA polymerase III	0.0004233361891707197	0.0004233361891707197	+1	CEBPA,AR,MTOR
DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 73%9675151	Disorders of developmental biology	0.0004233361891707197	0.0004233361891707197	+1	SIN3A,TBL1XR1,NCOR1
DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS%GOBP%GO:0060560	developmental growth involved in morphogenesis	0.0004372030628038007	0.0004372030628038007	+1	NOTCH1,CTNNB1,SOX9,FGFR2,USP9X
CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20200810%WP2406%HOMO SAPIENS	Cardiac Progenitor Differentiation	0.0004372030628038007	0.0004372030628038007	+1	NOTCH1,KIT,PDGFRA,FOXA2,SOX17
APOPTOSIS%WIKIPATHWAYS_20200810%WP254%HOMO SAPIENS	Apoptosis	0.00045695349666442206	0.00045695349666442206	+1	TP53,PIK3R1,CDKN2A,MAP3K1,MAP2K4,AKT1
REGULATION OF DNA REPLICATION%GOBP%GO:0006275	regulation of DNA replication	0.00045695349666442206	0.00045695349666442206	+1	EGFR,ATRX,CHEK2,PPP2R1A,ATR,SMC3
SKELETAL SYSTEM MORPHOGENESIS%GOBP%GO:0048705	skeletal system morphogenesis	0.00045695349666442206	0.00045695349666442206	+1	CTNNB1,SOX9,PDGFRA,FGFR2,FGFR3,TGFBR2
REGULATION OF TELOMERASE CATALYTIC CORE COMPLEX ASSEMBLY%GOBP%GO:1904882	regulation of telomerase catalytic core complex assembly	0.00047238627735516855	0.00047238627735516855	+1	ATM,ATR
PROSTATE GLAND MORPHOGENETIC GROWTH%GOBP%GO:0060737	prostate gland morphogenetic growth	0.00047238627735516855	0.00047238627735516855	+1	SOX9,FGFR2
IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS	IL2-mediated signaling events	0.00047238627735516855	0.00047238627735516855	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
ESTABLISHMENT OF RNA LOCALIZATION TO TELOMERE%GOBP%GO:0097694	establishment of RNA localization to telomere	0.00047238627735516855	0.00047238627735516855	+1	ATM,ATR
ESTABLISHMENT OF PROTEIN-CONTAINING COMPLEX LOCALIZATION TO TELOMERE%GOBP%GO:0097695	establishment of protein-containing complex localization to telomere	0.00047238627735516855	0.00047238627735516855	+1	ATM,ATR
REGULATION OF CARDIAC MUSCLE TISSUE REGENERATION%GOBP%GO:1905178	regulation of cardiac muscle tissue regeneration	0.00047238627735516855	0.00047238627735516855	+1	CDKN1B,CDKN1A
SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.4	Signaling by ERBB4	0.00047238627735516855	0.00047238627735516855	+1	PIK3CA,EGFR,PIK3R1,NRAS,NCOR1
CARDIAC VENTRICLE MORPHOGENESIS%GOBP%GO:0003208	cardiac ventricle morphogenesis	0.00047238627735516855	0.00047238627735516855	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
NEGATIVE REGULATION OF CARDIAC MUSCLE TISSUE REGENERATION%GOBP%GO:1905179	negative regulation of cardiac muscle tissue regeneration	0.00047238627735516855	0.00047238627735516855	+1	CDKN1B,CDKN1A
POSITIVE REGULATION OF TELOMERASE CATALYTIC CORE COMPLEX ASSEMBLY%GOBP%GO:1904884	positive regulation of telomerase catalytic core complex assembly	0.00047238627735516855	0.00047238627735516855	+1	ATM,ATR
NEGATIVE REGULATION OF DNA METABOLIC PROCESS%GOBP%GO:0051053	negative regulation of DNA metabolic process	0.0004733583769285144	0.0004733583769285144	+1	TP53,ATM,POLQ,CHEK2,HIST1H1C,CDKN1A,ATR
NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE	Nephrin Neph1 signaling in the kidney podocyte	0.0004733583769285144	0.0004733583769285144	+1	PIK3CA,PIK3R1,MAP2K4,AKT1
BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS	BARD1 signaling events	0.0004733583769285144	0.0004733583769285144	+1	TP53,ATM,BRCA1,ATR
POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY%GOBP%GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	0.0004733583769285144	0.0004733583769285144	+1	FLT3,KIT,PDGFRA,FGFR3
PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY	PID_TRAIL_PATHWAY	0.0004733583769285144	0.0004733583769285144	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4
HAIR FOLLICLE DEVELOPMENT: CYTODIFFERENTIATION (PART 3 OF 3)%WIKIPATHWAYS_20200810%WP2840%HOMO SAPIENS	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)	0.000473883539981195	0.000473883539981195	+1	EGFR,GATA3,NOTCH1,CTNNB1,SOX9,SMAD4
RESPONSE TO IONIZING RADIATION%GOBP%GO:0010212	response to ionizing radiation	0.000473883539981195	0.000473883539981195	+1	TP53,STK11,ATM,BRCA1,CDKN1A,ATR
APOPTOSIS%REACTOME%R-HSA-109581.3	Apoptosis	0.0004746659436468042	0.0004746659436468042	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,AKT1,TLR4,HIST1H1C
DNA PACKAGING%GOBP%GO:0006323	DNA packaging	0.000493441345041514	0.000493441345041514	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD
WNT_SIGNALING%MSIGDB_C2%WNT_SIGNALING	WNT_SIGNALING	0.0005017154782447791	0.0005017154782447791	+1	APC,CTNNB1,EP300,CCND1,SOX17,PPP2R1A
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-HSA-9616222.2	Transcriptional regulation of granulopoiesis	0.0005017154782447791	0.0005017154782447791	+1	RUNX1,CEBPA,EP300,CDKN1A,CBFB,HIST1H2BD
PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY	PID_IL2_1PATHWAY	0.0005024579499984818	0.0005024579499984818	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
REGULATION OF HEART GROWTH%GOBP%GO:0060420	regulation of heart growth	0.0005294554135266597	0.0005294554135266597	+1	NOTCH1,WT1,ERBB4,FGFR2
PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY	PID_REELIN_PATHWAY	0.0005294554135266597	0.0005294554135266597	+1	PIK3CA,PIK3R1,AKT1,MAPK8IP1
IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY	IGF1 pathway	0.0005294554135266597	0.0005294554135266597	+1	PIK3CA,PIK3R1,AKT1,PTPN11
BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY	BIOCARTA_HDAC_PATHWAY	0.0005294554135266597	0.0005294554135266597	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
ADIPOGENESIS%WIKIPATHWAYS_20200810%WP236%HOMO SAPIENS	Adipogenesis	0.0005294554135266597	0.0005294554135266597	+1	GATA3,RB1,CTNNB1,CEBPA,CDKN1A,LIFR,NCOR1
CHROMOSOME SEGREGATION%GOBP%GO:0007059	chromosome segregation	0.0005294554135266597	0.0005294554135266597	+1	RB1,FBXW7,STAG2,BRCA1,PPP2R1A,SMC1A,SMC3,RAD21,ERCC2
REGULATION OF HEART MORPHOGENESIS%GOBP%GO:2000826	regulation of heart morphogenesis	0.0005294554135266597	0.0005294554135266597	+1	NOTCH1,CTNNB1,SMAD4,TGFBR2
VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS	VEGFR1 specific signals	0.0005294554135266597	0.0005294554135266597	+1	PIK3CA,PIK3R1,AKT1,PTPN11
PROGRAMMED CELL DEATH%REACTOME%R-HSA-5357801.2	Programmed Cell Death	0.0005294554135266597	0.0005294554135266597	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,AKT1,TLR4,HIST1H1C
BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY	BIOCARTA_VEGF_PATHWAY	0.0005294554135266597	0.0005294554135266597	+1	PIK3CA,VHL,PIK3R1,PIK3CG
PDGFR-BETA PATHWAY%WIKIPATHWAYS_20200810%WP3972%HOMO SAPIENS	PDGFR-beta pathway	0.0005294554135266597	0.0005294554135266597	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4
POSITIVE REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS%GOBP%GO:1901800	positive regulation of proteasomal protein catabolic process	0.0005294554135266597	0.0005294554135266597	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
MORPHOGENESIS OF A BRANCHING STRUCTURE%GOBP%GO:0001763	morphogenesis of a branching structure	0.00053625547879612	0.00053625547879612	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY%GOBP%GO:0010518	positive regulation of phospholipase activity	0.00053625547879612	0.00053625547879612	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
POSITIVE REGULATION OF MESENCHYMAL CELL PROLIFERATION%GOBP%GO:0002053	positive regulation of mesenchymal cell proliferation	0.0005405910671140883	0.0005405910671140883	+1	SOX9,FGFR2,TGFBR2
ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20200810%WP3915%HOMO SAPIENS	Angiopoietin Like Protein 8 Regulatory Pathway	0.0005517839804146418	0.0005517839804146418	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG,MTOR
VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.3	VEGFA-VEGFR2 Pathway	0.0005523124434453547	0.0005523124434453547	+1	PIK3CA,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.1	TCF dependent signaling in response to WNT	0.0005692008162981999	0.0005692008162981999	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS%GOBP%GO:0031330	negative regulation of cellular catabolic process	0.0005692008162981999	0.0005692008162981999	+1	PIK3CA,AKT1,HGF,MTOR,LRRK2,TAF1,NCOR1,RPL5,AXIN2
TGF-BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20200810%WP560%HOMO SAPIENS	TGF-beta Receptor Signaling	0.0005760600661783289	0.0005760600661783289	+1	CTNNB1,EP300,SMAD4,TGFBR2,SMAD2
SIGNALING BY FGFR IN DISEASE%REACTOME DATABASE ID RELEASE 73%1226099	Signaling by FGFR in disease	0.0005760600661783289	0.0005760600661783289	+1	PIK3CA,PIK3R1,NRAS,FGFR2,FGFR3
IL-1 SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP195%HOMO SAPIENS	IL-1 signaling pathway	0.0005760600661783289	0.0005760600661783289	+1	PIK3R1,MAP3K1,MAP2K4,AKT1,PTPN11
CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20200810%WP2795%HOMO SAPIENS	Cardiac Hypertrophic Response	0.0005760600661783289	0.0005760600661783289	+1	MAP3K1,MAP2K4,AKT1,MTOR,FGFR2
RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.1	RUNX2 regulates bone development	0.0005923160803733901	0.0005923160803733901	+1	RB1,AR,SMAD4,CBFB
AORTIC VALVE DEVELOPMENT%GOBP%GO:0003176	aortic valve development	0.0005923160803733901	0.0005923160803733901	+1	GATA3,RB1,NOTCH1,SOX9
PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY	PID_IGF1_PATHWAY	0.0005923160803733901	0.0005923160803733901	+1	PIK3CA,PIK3R1,AKT1,PTPN11
NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY	Nectin adhesion pathway	0.0005923160803733901	0.0005923160803733901	+1	PIK3CA,PIK3R1,CTNNB1,CDH1
PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY	PID_NECTIN_PATHWAY	0.0005923160803733901	0.0005923160803733901	+1	PIK3CA,PIK3R1,CTNNB1,CDH1
CARDIAC CHAMBER DEVELOPMENT%GOBP%GO:0003205	cardiac chamber development	0.000649902533382278	0.000649902533382278	+1	GATA3,NOTCH1,TBX3,FGFR2,SMAD4,TGFBR2
POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION%GOBP%GO:0050679	positive regulation of epithelial cell proliferation	0.0006519168282567283	0.0006519168282567283	+1	EGFR,NRAS,AKT1,SOX9,TLR4,FGFR2,EGR3
PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY	PID_NEPHRIN_NEPH1_PATHWAY	0.0006647677762049931	0.0006647677762049931	+1	PIK3CA,PIK3R1,MAP2K4,AKT1
PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY	PID_AURORA_A_PATHWAY	0.0006647677762049931	0.0006647677762049931	+1	TP53,AKT1,AJUBA,BRCA1
AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING	Aurora A signaling	0.0006647677762049931	0.0006647677762049931	+1	TP53,AKT1,AJUBA,BRCA1
RESPONSE TO INTERLEUKIN-6%GOBP%GO:0070741	response to interleukin-6	0.0006647677762049931	0.0006647677762049931	+1	CEBPA,SMAD4,FOXA2,PTPN11
IL5%NETPATH%IL5	IL5	0.0006647677762049931	0.0006647677762049931	+1	PIK3R1,CTNNB1,AKT1,PIK3CG,PTPN11
CELLULAR SENESCENCE%GOBP%GO:0090398	cellular senescence	0.0006647677762049931	0.0006647677762049931	+1	TP53,CDKN2A,TBX3,CDKN1A
CD28 CO-STIMULATION%REACTOME%R-HSA-389356.2	CD28 co-stimulation	0.0006647677762049931	0.0006647677762049931	+1	PIK3CA,PIK3R1,AKT1,MTOR
PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY	PID_AR_NONGENOMIC_PATHWAY	0.0006647677762049931	0.0006647677762049931	+1	PIK3CA,PIK3R1,AKT1,AR
NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING	Nongenotropic Androgen signaling	0.0006647677762049931	0.0006647677762049931	+1	PIK3CA,PIK3R1,AKT1,AR
G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.5	G2 M DNA damage checkpoint	0.0006779226945131684	0.0006779226945131684	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
POSITIVE REGULATION OF LEUKOCYTE CELL-CELL ADHESION%GOBP%GO:1903039	positive regulation of leukocyte cell-cell adhesion	0.0006801389398660683	0.0006801389398660683	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
CIRCADIAN BEHAVIOR%GOBP%GO:0048512	circadian behavior	0.0006844515981824645	0.0006844515981824645	+1	TP53,PTEN,NCOR1
RHYTHMIC BEHAVIOR%GOBP%GO:0007622	rhythmic behavior	0.0006844515981824645	0.0006844515981824645	+1	TP53,PTEN,NCOR1
BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY	BIOCARTA_TRKA_PATHWAY	0.0006844515981824645	0.0006844515981824645	+1	PIK3CA,PIK3R1,AKT1
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.1	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.0006844515981824645	0.0006844515981824645	+1	PIK3CA,PIK3R1,PIK3CG
DNA CONFORMATION CHANGE%GOBP%GO:0071103	DNA conformation change	0.0007086571050522127	0.0007086571050522127	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD,ERCC2
KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP304%HOMO SAPIENS	Kit receptor signaling pathway	0.0007111943078684103	0.0007111943078684103	+1	PIK3R1,AKT1,KIT,EP300,PTPN11
MAMMARY GLAND DEVELOPMENT PATHWAY - PREGNANCY AND LACTATION (STAGE 3 OF 4)%WIKIPATHWAYS_20200810%WP2817%HOMO SAPIENS	Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)	0.0007406432332564421	0.0007406432332564421	+1	EGFR,CEBPA,ERBB4,CCND1
ERBB2 SIGNALING PATHWAY%GOBP%GO:0038128	ERBB2 signaling pathway	0.0007406432332564421	0.0007406432332564421	+1	PIK3CA,EGFR,PIK3R1,ERBB4
POSITIVE REGULATION OF LIPID KINASE ACTIVITY%GOBP%GO:0090218	positive regulation of lipid kinase activity	0.0007406432332564421	0.0007406432332564421	+1	FLT3,KIT,PDGFRA,FGFR3
POSITIVE REGULATION OF GLUCOSE TRANSMEMBRANE TRANSPORT%GOBP%GO:0010828	positive regulation of glucose transmembrane transport	0.0007406432332564421	0.0007406432332564421	+1	PIK3R1,AKT1,BRAF,PTPN11
NEGATIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0010719	negative regulation of epithelial to mesenchymal transition	0.0007406432332564421	0.0007406432332564421	+1	PTEN,GATA3,FOXA1,FOXA2
REGULATION OF RESPONSE TO WOUNDING%GOBP%GO:1903034	regulation of response to wounding	0.0007554884686060493	0.0007554884686060493	+1	PTEN,CDKN1B,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A
CARDIAC SEPTUM DEVELOPMENT%GOBP%GO:0003279	cardiac septum development	0.0007619752905707488	0.0007619752905707488	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
REGULATION OF PROTEOLYSIS INVOLVED IN CELLULAR PROTEIN CATABOLIC PROCESS%GOBP%GO:1903050	regulation of proteolysis involved in cellular protein catabolic process	0.0008018531309915989	0.0008018531309915989	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
REGULATION OF CIRCADIAN RHYTHM%GOBP%GO:0042752	regulation of circadian rhythm	0.0008267505831269239	0.0008267505831269239	+1	TP53,FBXW7,MTOR,USP9X,SIN3A,EZH2
GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 73%114604	GPVI-mediated activation cascade	0.0008267505831269239	0.0008267505831269239	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20200810%WP4204%HOMO SAPIENS	Tumor suppressor activity of SMARCB1	0.0008267505831269239	0.0008267505831269239	+1	ARID1A,CDKN2A,RB1,EZH2
ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 73%2559585	Oncogene Induced Senescence	0.0008267505831269239	0.0008267505831269239	+1	TP53,CDKN2A,RB1,CDKN2C
MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20200810%WP3982%HOMO SAPIENS	miRNA regulation of p53 pathway in prostate cancer	0.0008267505831269239	0.0008267505831269239	+1	TP53,PTEN,ATM,CHEK2
PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY	PID_NCADHERIN_PATHWAY	0.0008267505831269239	0.0008267505831269239	+1	PIK3CA,PIK3R1,CTNNB1,PTPN11
ACTIVATION OF PROTEIN KINASE ACTIVITY%GOBP%GO:0032147	activation of protein kinase activity	0.0008355834465380858	0.0008355834465380858	+1	MAP2K4,STK11,AKT1,BRAF,MTOR,TLR4,LRRK2,KIT,TGFBR2
BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY	BIOCARTA_RB_PATHWAY	0.000856495237897447	0.000856495237897447	+1	TP53,RB1,ATM
SA_REG_CASCADE_OF_CYCLIN_EXPR%MSIGDB_C2%SA_REG_CASCADE_OF_CYCLIN_EXPR	SA_REG_CASCADE_OF_CYCLIN_EXPR	0.000856495237897447	0.000856495237897447	+1	CDKN2A,CDKN1B,CCND1
PI-3K CASCADE:FGFR3%REACTOME%R-HSA-5654710.2	PI-3K cascade:FGFR3	0.000856495237897447	0.000856495237897447	+1	PIK3CA,PIK3R1,PTPN11
NEGATIVE REGULATION OF MYOBLAST DIFFERENTIATION%GOBP%GO:0045662	negative regulation of myoblast differentiation	0.000856495237897447	0.000856495237897447	+1	NOTCH1,TBX3,SOX9
PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.3	PI3K events in ERBB2 signaling	0.000856495237897447	0.000856495237897447	+1	PIK3CA,EGFR,PIK3R1
LNCRNA INVOLVEMENT IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20200810%WP4258%HOMO SAPIENS	LncRNA involvement in canonical Wnt signaling and colorectal cancer	0.0008646098241931503	0.0008646098241931503	+1	APC,CTNNB1,CCND1,SOX17,AXIN2,EZH2
CARDIOCYTE DIFFERENTIATION%GOBP%GO:0035051	cardiocyte differentiation	0.0008699660386218945	0.0008699660386218945	+1	NOTCH1,WT1,PDGFRA,SMAD4,SOX17
BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP2380%HOMO SAPIENS	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway	0.0008788864024736845	0.0008788864024736845	+1	APC,PIK3R1,CTNNB1,MAP3K1,AKT1,MTOR,PTPN11
SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 73%194138	Signaling by VEGF	0.0009095342095741918	0.0009095342095741918	+1	PIK3CA,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
SIG_CD40PATHWAYMAP%MSIGDB_C2%SIG_CD40PATHWAYMAP	SIG_CD40PATHWAYMAP	0.0009140103207673334	0.0009140103207673334	+1	PIK3CA,PIK3R1,MAP2K4,MAPK8IP1
ST_WNT_BETA_CATENIN_PATHWAY%MSIGDB_C2%ST_WNT_BETA_CATENIN_PATHWAY	ST_WNT_BETA_CATENIN_PATHWAY	0.0009140103207673334	0.0009140103207673334	+1	APC,CTNNB1,AKT1,AXIN2
SIGNALING OF HEPATOCYTE GROWTH FACTOR RECEPTOR%WIKIPATHWAYS_20200810%WP313%HOMO SAPIENS	Signaling of Hepatocyte Growth Factor Receptor	0.0009140103207673334	0.0009140103207673334	+1	PIK3CA,PTEN,HGF,PTPN11
SIGNALING BY MET%REACTOME DATABASE ID RELEASE 73%6806834	Signaling by MET	0.0009298423764194846	0.0009298423764194846	+1	PIK3CA,PIK3R1,NRAS,HGF,PTPN11
CELLULAR RESPONSE TO INORGANIC SUBSTANCE%GOBP%GO:0071241	cellular response to inorganic substance	0.0009495407574592769	0.0009495407574592769	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,ATRX,LRRK2
REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE/THREONINE KINASE SIGNALING PATHWAY%GOBP%GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.0009629542716239737	0.0009629542716239737	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
RAS PROTEIN SIGNAL TRANSDUCTION%GOBP%GO:0007265	Ras protein signal transduction	0.0009879002456743653	0.0009879002456743653	+1	TP53,KRAS,NF1,CDKN2A,RB1,NRAS,CDKN1A
REGULATION OF PHOSPHOLIPID METABOLIC PROCESS%GOBP%GO:1903725	regulation of phospholipid metabolic process	0.0009898003726533735	0.0009898003726533735	+1	PIK3R1,FLT3,KIT,PDGFRA,FGFR3
ST_FAS_SIGNALING_PATHWAY%MSIGDB_C2%ST_FAS_SIGNALING_PATHWAY	ST_FAS_SIGNALING_PATHWAY	0.0009898003726533735	0.0009898003726533735	+1	TP53,EGFR,MAP3K1,MAP2K4,MAPK8IP1
PEPTIDYL-THREONINE PHOSPHORYLATION%GOBP%GO:0018107	peptidyl-threonine phosphorylation	0.0009898003726533735	0.0009898003726533735	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS	TCR signaling in naive CD4+ T cells	0.0009898003726533735	0.0009898003726533735	+1	PTEN,KRAS,NRAS,AKT1,PTPN11
PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY	PID_BCR_5PATHWAY	0.0009898003726533735	0.0009898003726533735	+1	PIK3CA,PTEN,PIK3R1,MAP3K1,AKT1
CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT	Class I PI3K signaling events mediated by Akt	0.0010013413671688285	0.0010013413671688285	+1	AKT1,CDKN1B,MTOR,CDKN1A
SEMI-LUNAR VALVE DEVELOPMENT%GOBP%GO:1905314	semi-lunar valve development	0.0010013413671688285	0.0010013413671688285	+1	GATA3,RB1,NOTCH1,SOX9
PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY	PID_PI3KCI_AKT_PATHWAY	0.0010013413671688285	0.0010013413671688285	+1	AKT1,CDKN1B,MTOR,CDKN1A
VASCULOGENESIS%GOBP%GO:0001570	vasculogenesis	0.0010013413671688285	0.0010013413671688285	+1	NOTCH1,WT1,TGFBR2,SOX17
ALPHA 6 BETA 4 SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP244%HOMO SAPIENS	Alpha 6 Beta 4 signaling pathway	0.0010013413671688285	0.0010013413671688285	+1	PIK3R1,AKT1,MTOR,PTPN11
ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS	ErbB4 signaling events	0.0010013413671688285	0.0010013413671688285	+1	PIK3CA,PIK3R1,ERBB4,NCOR1
MESENCHYME MORPHOGENESIS%GOBP%GO:0072132	mesenchyme morphogenesis	0.0010013413671688285	0.0010013413671688285	+1	NOTCH1,SOX9,TGFBR2,SMAD2
FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY	FAS (CD95) signaling pathway	0.0010013413671688285	0.0010013413671688285	+1	PIK3CA,PIK3R1,MAP3K1,AKT1
REGULATION OF PHOSPHOLIPASE ACTIVITY%GOBP%GO:0010517	regulation of phospholipase activity	0.0010236777251104324	0.0010236777251104324	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
REGULATION OF STEM CELL DIFFERENTIATION%GOBP%GO:2000736	regulation of stem cell differentiation	0.0010236777251104324	0.0010236777251104324	+1	GATA3,NOTCH1,RUNX1,SOX9,PDGFRA,CBFB
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 73%198323	AKT phosphorylates targets in the cytosol	0.0010236777251104324	0.0010236777251104324	+1	AKT1,CDKN1B,CDKN1A
MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY	mTOR signaling pathway	0.0010236777251104324	0.0010236777251104324	+1	KRAS,NRAS,AKT1,BRAF,MTOR
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 73%6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.0010236777251104324	0.0010236777251104324	+1	TP53,CDKN1B,CDKN1A
SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 73%1295596	Spry regulation of FGF signaling	0.0010236777251104324	0.0010236777251104324	+1	BRAF,PPP2R1A,PTPN11
BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY	BIOCARTA_PS1_PATHWAY	0.0010236777251104324	0.0010236777251104324	+1	APC,NOTCH1,CTNNB1
CARDIAC LEFT VENTRICLE MORPHOGENESIS%GOBP%GO:0003214	cardiac left ventricle morphogenesis	0.0010236777251104324	0.0010236777251104324	+1	NOTCH1,SMAD4,TGFBR2
RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY	Ras signaling in the CD4+ TCR pathway	0.0010236777251104324	0.0010236777251104324	+1	KRAS,NRAS,BRAF
IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS	IL5-mediated signaling events	0.0010236777251104324	0.0010236777251104324	+1	PIK3CA,PIK3R1,PTPN11
PRADER-WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20200810%WP3998%HOMO SAPIENS	Prader-Willi and Angelman Syndrome	0.0010236777251104324	0.0010236777251104324	+1	TP53,CDKN2A,RB1,CCND1,CDKN2C
BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY	BCR signaling pathway	0.0010236777251104324	0.0010236777251104324	+1	PIK3CA,PTEN,PIK3R1,MAP3K1,AKT1
POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION%GOBP%GO:0060045	positive regulation of cardiac muscle cell proliferation	0.0010236777251104324	0.0010236777251104324	+1	NOTCH1,ERBB4,FGFR2
RESPONSE TO UV-A%GOBP%GO:0070141	response to UV-A	0.0010236777251104324	0.0010236777251104324	+1	EGFR,AKT1,CCND1
TOLL-LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP75%HOMO SAPIENS	Toll-like Receptor Signaling Pathway	0.0010236777251104324	0.0010236777251104324	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PIK3CG,TLR4
CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20200810%WP4582%HOMO SAPIENS	Cancer immunotherapy by CTLA4 blockade	0.0010236777251104324	0.0010236777251104324	+1	PIK3CA,PIK3R1,PTPN11
PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY	PID_TCR_RAS_PATHWAY	0.0010236777251104324	0.0010236777251104324	+1	KRAS,NRAS,BRAF
PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY	PID_TCR_PATHWAY	0.0010236777251104324	0.0010236777251104324	+1	PTEN,KRAS,NRAS,AKT1,PTPN11
PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY	PID_IL5_PATHWAY	0.0010236777251104324	0.0010236777251104324	+1	PIK3CA,PIK3R1,PTPN11
SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 73%9034015	Signaling by NTRK3 (TRKC)	0.0010236777251104324	0.0010236777251104324	+1	PIK3CA,PIK3R1,NRAS
POSITIVE REGULATION OF GROWTH%GOBP%GO:0045927	positive regulation of growth	0.0010679400334108152	0.0010679400334108152	+1	EGFR,NOTCH1,AKT1,WT1,ERBB4,FGFR2,H3F3C
N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS	N-cadherin signaling events	0.0010789235507323496	0.0010789235507323496	+1	PIK3CA,PIK3R1,CTNNB1,PTPN11
TYPE 2 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20200810%WP4241%HOMO SAPIENS	Type 2 papillary renal cell carcinoma	0.0010789235507323496	0.0010789235507323496	+1	VHL,SETD2,EP300,CDKN1A
PI3K CASCADE%REACTOME DATABASE ID RELEASE 73%109704	PI3K Cascade	0.0010789235507323496	0.0010789235507323496	+1	PIK3CA,PIK3R1,FLT3,PTPN11
SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	0.0010789235507323496	0.0010789235507323496	+1	PIK3CA,PTEN,CDKN2A,AKT1
ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 73%9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	0.0010789235507323496	0.0010789235507323496	+1	RB1,CDKN1B,CCND1,CDKN1A
DISEASES OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 73%9675126	Diseases of mitotic cell cycle	0.0010789235507323496	0.0010789235507323496	+1	RB1,CDKN1B,CCND1,CDKN1A
POSITIVE REGULATION OF LIPASE ACTIVITY%GOBP%GO:0060193	positive regulation of lipase activity	0.0010875921403461473	0.0010875921403461473	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006	Apoptosis signaling pathway	0.0011081851759778465	0.0011081851759778465	+1	TP53,PIK3CA,MAP3K1,MAP2K4,AKT1,PIK3CG
INTESTINAL EPITHELIAL STRUCTURE MAINTENANCE%GOBP%GO:0060729	intestinal epithelial structure maintenance	0.0011358330191557253	0.0011358330191557253	+1	SOX9,TLR4
E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS	E-cadherin signaling events	0.0011358330191557253	0.0011358330191557253	+1	CTNNB1,CDH1
CELLULAR RESPONSE TO LITHIUM ION%GOBP%GO:0071285	cellular response to lithium ion	0.0011358330191557253	0.0011358330191557253	+1	CDH1,CDKN1B
LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 73%3304347	Loss of Function of SMAD4 in Cancer	0.0011358330191557253	0.0011358330191557253	+1	SMAD4,SMAD2
PEPTIDYL-SERINE PHOSPHORYLATION%GOBP%GO:0018105	peptidyl-serine phosphorylation	0.0011358330191557253	0.0011358330191557253	+1	AKT1,ATM,MTOR,LRRK2,TGFBR2,TAF1,ATR
REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL%GOBP%GO:1903320	regulation of protein modification by small protein conjugation or removal	0.0011358330191557253	0.0011358330191557253	+1	PTEN,FBXW7,CTNNB1,AKT1,BRCA1,LRRK2,TAF1,RPL5
SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 73%3315487	SMAD2 3 MH2 Domain Mutants in Cancer	0.0011358330191557253	0.0011358330191557253	+1	SMAD4,SMAD2
SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 73%3311021	SMAD4 MH2 Domain Mutants in Cancer	0.0011358330191557253	0.0011358330191557253	+1	SMAD4,SMAD2
REGULATION OF CELL PROLIFERATION INVOLVED IN HEART VALVE MORPHOGENESIS%GOBP%GO:0003250	regulation of cell proliferation involved in heart valve morphogenesis	0.0011358330191557253	0.0011358330191557253	+1	NOTCH1,SMAD4
RESPONSE TO LITHIUM ION%GOBP%GO:0010226	response to lithium ion	0.0011358330191557253	0.0011358330191557253	+1	CDH1,CDKN1B
PROSTATE GLAND EPITHELIUM MORPHOGENESIS%GOBP%GO:0060740	prostate gland epithelium morphogenesis	0.0011358330191557253	0.0011358330191557253	+1	SOX9,FGFR2
RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 73%9649913	RAS GTPase cycle mutants	0.0011358330191557253	0.0011358330191557253	+1	KRAS,NRAS
RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 73%8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	0.0011358330191557253	0.0011358330191557253	+1	RUNX1,CBFB
NEGATIVE REGULATION OF MAMMARY GLAND EPITHELIAL CELL PROLIFERATION%GOBP%GO:0033600	negative regulation of mammary gland epithelial cell proliferation	0.0011358330191557253	0.0011358330191557253	+1	GATA3,BRCA2
FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS	FOXA transcription factor networks	0.0011358330191557253	0.0011358330191557253	+1	FOXA1,FOXA2
CANONICAL WNT SIGNALING PATHWAY%GOBP%GO:0060070	canonical Wnt signaling pathway	0.0011375357957334432	0.0011375357957334432	+1	PTEN,APC,GATA3,CTNNB1,LRRK2
REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN%GOBP%GO:0042509	regulation of tyrosine phosphorylation of STAT protein	0.0011375357957334432	0.0011375357957334432	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
POSITIVE REGULATION OF TYPE I INTERFERON PRODUCTION%GOBP%GO:0032481	positive regulation of type I interferon production	0.0011375357957334432	0.0011375357957334432	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
REGULATION OF KIDNEY DEVELOPMENT%GOBP%GO:0090183	regulation of kidney development	0.0011601525653721666	0.0011601525653721666	+1	GATA3,CTNNB1,SOX9,WT1
EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS%GOBP%GO:0048704	embryonic skeletal system morphogenesis	0.0011601525653721666	0.0011601525653721666	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY	BIOCARTA_ALK_PATHWAY	0.0011601525653721666	0.0011601525653721666	+1	APC,CTNNB1,SMAD4,TGFBR2
PRION DISEASE PATHWAY%WIKIPATHWAYS_20200810%WP3995%HOMO SAPIENS	Prion disease pathway	0.0011601525653721666	0.0011601525653721666	+1	CTCF,EP300,SMC3,RAD21
POSITIVE REGULATION OF CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:1902808	positive regulation of cell cycle G1/S phase transition	0.0011601525653721666	0.0011601525653721666	+1	EGFR,AKT1,CCND1,EZH2
ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY%MSIGDB_C2%ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	0.0011601525653721666	0.0011601525653721666	+1	PIK3CA,PTEN,CDKN2A,AKT1
NEOVASCULARISATION PROCESSES%WIKIPATHWAYS_20200810%WP4331%HOMO SAPIENS	Neovascularisation processes	0.0011601525653721666	0.0011601525653721666	+1	NOTCH1,AKT1,KIT,SMAD2
POSITIVE REGULATION OF MESONEPHROS DEVELOPMENT%GOBP%GO:0061213	positive regulation of mesonephros development	0.0011733842237098664	0.0011733842237098664	+1	GATA3,SOX9,WT1
NEGATIVE REGULATION OF RESPONSE TO REACTIVE OXYGEN SPECIES%GOBP%GO:1901032	negative regulation of response to reactive oxygen species	0.0011733842237098664	0.0011733842237098664	+1	NFE2L2,HGF,LRRK2
S37 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 73%5358749	S37 mutants of beta-catenin aren't phosphorylated	0.0011733842237098664	0.0011733842237098664	+1	APC,CTNNB1,PPP2R1A
PROTEIN LOCALIZATION TO CHROMOSOME, TELOMERIC REGION%GOBP%GO:0070198	protein localization to chromosome, telomeric region	0.0011733842237098664	0.0011733842237098664	+1	ATRX,BRCA2,ATR
HISTONE METHYLATION%GOBP%GO:0016571	histone methylation	0.0011733842237098664	0.0011733842237098664	+1	KDM6A,TET2,SETD2,NSD1,EZH2
NEGATIVE REGULATION OF VASCULAR SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:1904706	negative regulation of vascular smooth muscle cell proliferation	0.0011733842237098664	0.0011733842237098664	+1	PTEN,CDKN1B,CDKN1A
SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.1	Signaling by Insulin receptor	0.0011733842237098664	0.0011733842237098664	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
PHYTOCHEMICAL ACTIVITY ON NRF2 TRANSCRIPTIONAL ACTIVATION%WIKIPATHWAYS_20200810%WP3%HOMO SAPIENS	Phytochemical activity on NRF2 transcriptional activation	0.0011733842237098664	0.0011733842237098664	+1	PIK3CA,KEAP1,NFE2L2
EMBRYONIC CRANIAL SKELETON MORPHOGENESIS%GOBP%GO:0048701	embryonic cranial skeleton morphogenesis	0.0011733842237098664	0.0011733842237098664	+1	PDGFRA,FGFR2,TGFBR2
BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY	BIOCARTA_PITX2_PATHWAY	0.0011733842237098664	0.0011733842237098664	+1	APC,CTNNB1,EP300
IL1%NETPATH%IL1	IL1	0.0011733842237098664	0.0011733842237098664	+1	PIK3R1,RB1,MAP2K4,AKT1,PTPN11
PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY	PID_MTOR_4PATHWAY	0.0011733842237098664	0.0011733842237098664	+1	KRAS,NRAS,AKT1,BRAF,MTOR
MISSPLICED GSK3BETA MUTANTS STABILIZE BETA-CATENIN%REACTOME%R-HSA-5339716.2	Misspliced GSK3beta mutants stabilize beta-catenin	0.0011733842237098664	0.0011733842237098664	+1	APC,CTNNB1,PPP2R1A
NEGATIVE REGULATION OF HYDROGEN PEROXIDE-INDUCED CELL DEATH%GOBP%GO:1903206	negative regulation of hydrogen peroxide-induced cell death	0.0011733842237098664	0.0011733842237098664	+1	NFE2L2,HGF,LRRK2
PHOSPHORYLATION SITE MUTANTS OF CTNNB1 ARE NOT TARGETED TO THE PROTEASOME BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-4839743.1	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	0.0011733842237098664	0.0011733842237098664	+1	APC,CTNNB1,PPP2R1A
REGULATION OF MESENCHYMAL CELL PROLIFERATION%GOBP%GO:0010464	regulation of mesenchymal cell proliferation	0.0011733842237098664	0.0011733842237098664	+1	SOX9,FGFR2,TGFBR2
POSITIVE REGULATION OF HISTONE H3-K4 METHYLATION%GOBP%GO:0051571	positive regulation of histone H3-K4 methylation	0.0011733842237098664	0.0011733842237098664	+1	CTNNB1,BRCA1,SMAD4
PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.2	PI-3K cascade:FGFR1	0.0011733842237098664	0.0011733842237098664	+1	PIK3CA,PIK3R1,PTPN11
T41 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 73%5358752	T41 mutants of beta-catenin aren't phosphorylated	0.0011733842237098664	0.0011733842237098664	+1	APC,CTNNB1,PPP2R1A
S33 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 73%5358747	S33 mutants of beta-catenin aren't phosphorylated	0.0011733842237098664	0.0011733842237098664	+1	APC,CTNNB1,PPP2R1A
S45 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 73%5358751	S45 mutants of beta-catenin aren't phosphorylated	0.0011733842237098664	0.0011733842237098664	+1	APC,CTNNB1,PPP2R1A
REGULATION OF CHROMATIN ORGANIZATION%GOBP%GO:1902275	regulation of chromatin organization	0.0011733842237098664	0.0011733842237098664	+1	CTNNB1,ATRX,BRCA1,HIST1H1C,SMAD4,SIN3A,NSD1
NEGATIVE REGULATION OF AUTOPHAGY%GOBP%GO:0010507	negative regulation of autophagy	0.0011733842237098664	0.0011733842237098664	+1	PIK3CA,AKT1,HGF,MTOR,LRRK2
NEGATIVE REGULATION OF CELLULAR RESPONSE TO DRUG%GOBP%GO:2001039	negative regulation of cellular response to drug	0.0011733842237098664	0.0011733842237098664	+1	NFE2L2,HGF,LRRK2
REGULATION OF HISTONE MODIFICATION%GOBP%GO:0031056	regulation of histone modification	0.0012094799823377444	0.0012094799823377444	+1	CTNNB1,ATRX,BRCA1,SMAD4,SIN3A,NSD1
BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY	BIOCARTA_IL2RB_PATHWAY	0.0012388301138921058	0.0012388301138921058	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY	PID_ERBB4_PATHWAY	0.0012388301138921058	0.0012388301138921058	+1	PIK3CA,PIK3R1,ERBB4,NCOR1
PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY	PID_FAS_PATHWAY	0.0012388301138921058	0.0012388301138921058	+1	PIK3CA,PIK3R1,MAP3K1,AKT1
RESPONSE TO ANTINEOPLASTIC AGENT%GOBP%GO:0097327	response to antineoplastic agent	0.0012388301138921058	0.0012388301138921058	+1	CTNNB1,CDH1,ATRX,BRCA1
SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 73%5655253	Signaling by FGFR2 in disease	0.0012388301138921058	0.0012388301138921058	+1	PIK3CA,PIK3R1,NRAS,FGFR2
REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0055024	regulation of cardiac muscle tissue development	0.0012388301138921058	0.0012388301138921058	+1	NOTCH1,ERBB4,FGFR2,SMAD4
REGULATION OF EPITHELIAL CELL DIFFERENTIATION%GOBP%GO:0030856	regulation of epithelial cell differentiation	0.0012601490987133855	0.0012601490987133855	+1	GATA3,CTNNB1,RUNX1,SOX9,CBFB,VEZF1
PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.1	Presynaptic phase of homologous DNA pairing and strand exchange	0.0013552367438888597	0.0013552367438888597	+1	ATM,BRCA1,BRCA2,ATR
REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.2	Regulation of beta-cell development	0.0013552367438888597	0.0013552367438888597	+1	NOTCH1,AKT1,EP300,FOXA2
EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING	EPHB forward signaling	0.0013552367438888597	0.0013552367438888597	+1	PIK3CA,KRAS,PIK3R1,NRAS
ST_JNK_MAPK_PATHWAY%MSIGDB_C2%ST_JNK_MAPK_PATHWAY	ST_JNK_MAPK_PATHWAY	0.0013552367438888597	0.0013552367438888597	+1	TP53,MAP3K1,MAP2K4,AKT1
THE INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20200810%WP4844%HOMO SAPIENS	The influence of laminopathies on Wnt signaling	0.0013552367438888597	0.0013552367438888597	+1	APC,CTNNB1,CEBPA,CCND1
MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20200810%WP4829%HOMO SAPIENS	mBDNF and proBDNF regulation of GABA neurotransmission	0.0013552367438888597	0.0013552367438888597	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
NEGATIVE REGULATION OF CELLULAR RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1900408	negative regulation of cellular response to oxidative stress	0.0013552367438888597	0.0013552367438888597	+1	NFE2L2,AKT1,HGF,LRRK2
NEGATIVE REGULATION OF OXIDATIVE STRESS-INDUCED CELL DEATH%GOBP%GO:1903202	negative regulation of oxidative stress-induced cell death	0.0013552367438888597	0.0013552367438888597	+1	NFE2L2,AKT1,HGF,LRRK2
TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME%R-HSA-8853884.2	Transcriptional Regulation by VENTX	0.0013552367438888597	0.0013552367438888597	+1	TP53,CDKN2A,CTNNB1,CCND1
MESENCHYMAL CELL DIFFERENTIATION%GOBP%GO:0048762	mesenchymal cell differentiation	0.0013729057015446364	0.0013729057015446364	+1	NOTCH1,CTNNB1,SOX9,HGF,ERBB4,FGFR2
MITOTIC SISTER CHROMATID COHESION%GOBP%GO:0007064	mitotic sister chromatid cohesion	0.001392008459751706	0.001392008459751706	+1	RB1,SMC1A,RAD21
BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY	BIOCARTA_CDC42RAC_PATHWAY	0.001392008459751706	0.001392008459751706	+1	PIK3CA,PIK3R1,PDGFRA
CELLULAR RESPONSE TO GAMMA RADIATION%GOBP%GO:0071480	cellular response to gamma radiation	0.001392008459751706	0.001392008459751706	+1	TP53,ATM,ATR
FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 73%2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.001392008459751706	0.001392008459751706	+1	TP53,RB1,HIST1H1C
SYMPATHETIC NERVOUS SYSTEM DEVELOPMENT%GOBP%GO:0048485	sympathetic nervous system development	0.001392008459751706	0.001392008459751706	+1	NF1,GATA3,CTNNB1
REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE-ANAPHASE TRANSITION%WIKIPATHWAYS_20200810%WP4240%HOMO SAPIENS	Regulation of sister chromatid separation at the metaphase-anaphase transition	0.001392008459751706	0.001392008459751706	+1	SMC1A,SMC3,RAD21
SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.1	Signaling by TGF-beta Receptor Complex	0.001392008459751706	0.001392008459751706	+1	SMAD4,USP9X,TGFBR2,NCOR1,SMAD2
BCR%NETPATH%BCR	BCR	0.0014259391132382206	0.0014259391132382206	+1	PIK3R1,RB1,CTNNB1,AKT1,BRAF,PIK3CG,PTPN11
HALLMARK_APOPTOSIS%MSIGDB_C2%HALLMARK_APOPTOSIS	HALLMARK_APOPTOSIS	0.0014259391132382206	0.0014259391132382206	+1	CTNNB1,CDKN1B,HGF,BRCA1,CCND1,CDKN1A,EGR3
NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20200810%WP4564%HOMO SAPIENS	Neural Crest Cell Migration during Development	0.0014678070436617687	0.0014678070436617687	+1	PIK3CA,AKT1,PIK3CG,EPHB6
POSITIVE REGULATION OF PROTEASOMAL UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0014678070436617687	0.0014678070436617687	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
CARDIAC VENTRICLE DEVELOPMENT%GOBP%GO:0003231	cardiac ventricle development	0.0014678070436617687	0.0014678070436617687	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
PDGF PATHWAY%WIKIPATHWAYS_20200810%WP2526%HOMO SAPIENS	PDGF Pathway	0.0014678070436617687	0.0014678070436617687	+1	PIK3R1,MAP3K1,MAP2K4,PTPN11
PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY	PID_EPHB_FWD_PATHWAY	0.0014678070436617687	0.0014678070436617687	+1	PIK3CA,KRAS,PIK3R1,NRAS
POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS%GOBP%GO:2000379	positive regulation of reactive oxygen species metabolic process	0.0014678070436617687	0.0014678070436617687	+1	TP53,AKT1,TLR4,TGFBR2,CDKN1A
NEGATIVE REGULATION OF LIPID METABOLIC PROCESS%GOBP%GO:0045833	negative regulation of lipid metabolic process	0.0015570456962139764	0.0015570456962139764	+1	FBXW7,AKT1,SOX9,BRCA1,NCOR1
POSITIVE REGULATION OF JAK-STAT CASCADE%GOBP%GO:0046427	positive regulation of JAK-STAT cascade	0.0015570456962139764	0.0015570456962139764	+1	NOTCH1,FLT3,ERBB4,KIT,FGFR3
PEPTIDYL-THREONINE MODIFICATION%GOBP%GO:0018210	peptidyl-threonine modification	0.0015570456962139764	0.0015570456962139764	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
NEGATIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1902883	negative regulation of response to oxidative stress	0.0016032306167927336	0.0016032306167927336	+1	NFE2L2,AKT1,HGF,LRRK2
KIDNEY MORPHOGENESIS%GOBP%GO:0060993	kidney morphogenesis	0.0016032306167927336	0.0016032306167927336	+1	GATA3,SOX9,WT1,LRRK2
STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION	Stabilization and expansion of the E-cadherin adherens junction	0.0016032306167927336	0.0016032306167927336	+1	EGFR,CTNNB1,CDH1,HGF
OXIDATIVE DAMAGE%WIKIPATHWAYS_20200810%WP3941%HOMO SAPIENS	Oxidative Damage	0.0016032306167927336	0.0016032306167927336	+1	MAP3K1,MAP2K4,CDKN1B,CDKN1A
NEGATIVE REGULATION OF CHROMOSOME ORGANIZATION%GOBP%GO:2001251	negative regulation of chromosome organization	0.0016148397641705535	0.0016148397641705535	+1	APC,ATM,ATRX,BRCA1,HIST1H1C,SIN3A
BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.1	Beta-catenin phosphorylation cascade	0.0016307876703769409	0.0016307876703769409	+1	APC,CTNNB1,PPP2R1A
SA_TRKA_RECEPTOR%MSIGDB_C2%SA_TRKA_RECEPTOR	SA_TRKA_RECEPTOR	0.0016307876703769409	0.0016307876703769409	+1	PIK3CA,AKT1,CDKN1A
REGULATION OF NEUROBLAST PROLIFERATION%GOBP%GO:1902692	regulation of neuroblast proliferation	0.0016307876703769409	0.0016307876703769409	+1	NF1,CTNNB1,LRRK2
PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY	PID_SMAD2_3PATHWAY	0.0016307876703769409	0.0016307876703769409	+1	MAP3K1,SMAD4,SMAD2
SA_PTEN_PATHWAY%MSIGDB_C2%SA_PTEN_PATHWAY	SA_PTEN_PATHWAY	0.0016307876703769409	0.0016307876703769409	+1	PIK3CA,PTEN,AKT1
CANONICAL AND NON-CANONICAL TGF-B SIGNALING%WIKIPATHWAYS_20200810%WP3874%HOMO SAPIENS	Canonical and Non-Canonical TGF-B signaling	0.0016307876703769409	0.0016307876703769409	+1	SMAD4,TGFBR2,SMAD2
POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE GROWTH%GOBP%GO:0055023	positive regulation of cardiac muscle tissue growth	0.0016307876703769409	0.0016307876703769409	+1	NOTCH1,ERBB4,FGFR2
PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 73%5654720	PI-3K cascade:FGFR4	0.0016307876703769409	0.0016307876703769409	+1	PIK3CA,PIK3R1,PTPN11
AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20200810%WP3678%HOMO SAPIENS	Amplification and Expansion of Oncogenic Pathways as Metastatic Traits	0.0016307876703769409	0.0016307876703769409	+1	VHL,NOTCH1,PIK3CG
CHEMOKINE SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP3929%HOMO SAPIENS	Chemokine signaling pathway	0.0016716183995305843	0.0016716183995305843	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,BRAF,PIK3CG
REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS%GOBP%GO:1903362	regulation of cellular protein catabolic process	0.0017009611338082218	0.0017009611338082218	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
POSITIVE REGULATION OF PHOSPHOLIPID METABOLIC PROCESS%GOBP%GO:1903727	positive regulation of phospholipid metabolic process	0.0017241205708242073	0.0017241205708242073	+1	FLT3,KIT,PDGFRA,FGFR3
LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS	LKB1 signaling events	0.0017241205708242073	0.0017241205708242073	+1	TP53,STK11,MTOR,SMAD4
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 73%5693579	Homologous DNA Pairing and Strand Exchange	0.0017241205708242073	0.0017241205708242073	+1	ATM,BRCA1,BRCA2,ATR
HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDB_C2%HALLMARK_WNT_BETA_CATENIN_SIGNALING	HALLMARK_WNT_BETA_CATENIN_SIGNALING	0.0017241205708242073	0.0017241205708242073	+1	TP53,NOTCH1,CTNNB1,AXIN2
PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY	PID_ECADHERIN_STABILIZATION_PATHWAY	0.0017241205708242073	0.0017241205708242073	+1	EGFR,CTNNB1,CDH1,HGF
REGULATION OF MITOCHONDRION ORGANIZATION%GOBP%GO:0010821	regulation of mitochondrion organization	0.0017241205708242073	0.0017241205708242073	+1	TP53,FBXW7,BAP1,AKT1,HGF,LRRK2,EP300
RHYTHMIC PROCESS%GOBP%GO:0048511	rhythmic process	0.0017335414055374572	0.0017335414055374572	+1	TP53,PTEN,PDGFRA,EP300,EGR3,NCOR1
CARDIAC CHAMBER MORPHOGENESIS%GOBP%GO:0003206	cardiac chamber morphogenesis	0.0018199508479759133	0.0018199508479759133	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
POSITIVE REGULATION OF STAT CASCADE%GOBP%GO:1904894	positive regulation of STAT cascade	0.0018199508479759133	0.0018199508479759133	+1	NOTCH1,FLT3,ERBB4,KIT,FGFR3
INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY	Insulin Pathway	0.0018742411506981957	0.0018742411506981957	+1	PIK3CA,PIK3R1,AKT1,PTPN11
HEART LOOPING%GOBP%GO:0001947	heart looping	0.0018742411506981957	0.0018742411506981957	+1	NOTCH1,TBX3,TGFBR2,SOX17
NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20200810%WP4565%HOMO SAPIENS	Neural Crest Cell Migration in Cancer	0.0018742411506981957	0.0018742411506981957	+1	PIK3CA,AKT1,PIK3CG,EPHB6
IL-6 SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP364%HOMO SAPIENS	IL-6 signaling pathway	0.0018742411506981957	0.0018742411506981957	+1	PIK3R1,MAP2K4,AKT1,PTPN11
REGULATION OF MESONEPHROS DEVELOPMENT%GOBP%GO:0061217	regulation of mesonephros development	0.0018853674759247803	0.0018853674759247803	+1	GATA3,SOX9,WT1
INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20200810%WP4301%HOMO SAPIENS	Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells	0.0018853674759247803	0.0018853674759247803	+1	KRAS,NRAS,BRAF
BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY	BIOCARTA_NGF_PATHWAY	0.0018853674759247803	0.0018853674759247803	+1	PIK3CA,PIK3R1,PIK3CG
INTERLEUKIN-6-MEDIATED SIGNALING PATHWAY%GOBP%GO:0070102	interleukin-6-mediated signaling pathway	0.0018853674759247803	0.0018853674759247803	+1	CEBPA,SMAD4,PTPN11
PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY	PID_BETA_CATENIN_DEG_PATHWAY	0.0018853674759247803	0.0018853674759247803	+1	APC,CTNNB1,AXIN2
REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2001185	regulation of CD8-positive, alpha-beta T cell activation	0.0018853674759247803	0.0018853674759247803	+1	RUNX1,CBFB,MAPK8IP1
REGULATION OF HYDROGEN PEROXIDE-INDUCED CELL DEATH%GOBP%GO:1903205	regulation of hydrogen peroxide-induced cell death	0.0018853674759247803	0.0018853674759247803	+1	NFE2L2,HGF,LRRK2
SECONDARY PALATE DEVELOPMENT%GOBP%GO:0062009	secondary palate development	0.0018853674759247803	0.0018853674759247803	+1	SMAD4,TGFBR2,SMAD2
ANGIOGENESIS%GOBP%GO:0001525	angiogenesis	0.0018853674759247803	0.0018853674759247803	+1	CTNNB1,AKT1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.2	PI-3K cascade:FGFR2	0.0018853674759247803	0.0018853674759247803	+1	PIK3CA,PIK3R1,PTPN11
DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN	Degradation of beta catenin	0.0018853674759247803	0.0018853674759247803	+1	APC,CTNNB1,AXIN2
METANEPHRIC NEPHRON DEVELOPMENT%GOBP%GO:0072210	metanephric nephron development	0.0018853674759247803	0.0018853674759247803	+1	SOX9,WT1,PDGFRA
P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK	p73 transcription factor network	0.0018905413152884144	0.0018905413152884144	+1	RB1,WT1,EP300,BRCA2,CDKN1A
PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY	PID_P73PATHWAY	0.0018905413152884144	0.0018905413152884144	+1	RB1,WT1,EP300,BRCA2,CDKN1A
REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:0048660	regulation of smooth muscle cell proliferation	0.0018905413152884144	0.0018905413152884144	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
OTIC VESICLE FORMATION%GOBP%GO:0030916	otic vesicle formation	0.0019307443276703425	0.0019307443276703425	+1	SOX9,FGFR2
NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001234	negative regulation of apoptotic signaling pathway	0.0019307443276703425	0.0019307443276703425	+1	RB1,NFE2L2,AKT1,AR,HGF,BRCA1,LRRK2
PROSTATE GLAND GROWTH%GOBP%GO:0060736	prostate gland growth	0.0019307443276703425	0.0019307443276703425	+1	SOX9,FGFR2
TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 73%69560	Transcriptional activation of p53 responsive genes	0.0019307443276703425	0.0019307443276703425	+1	TP53,CDKN1A
MONOUBIQUITINATED HISTONE H2A DEUBIQUITINATION%GOBP%GO:0035522	monoubiquitinated histone H2A deubiquitination	0.0019307443276703425	0.0019307443276703425	+1	BAP1,ASXL1
TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 73%69895	Transcriptional activation of cell cycle inhibitor p21	0.0019307443276703425	0.0019307443276703425	+1	TP53,CDKN1A
HOMEOSTASIS OF NUMBER OF CELLS WITHIN A TISSUE%GOBP%GO:0048873	homeostasis of number of cells within a tissue	0.0019307443276703425	0.0019307443276703425	+1	NOTCH1,SOX9
PEPTIDYL-SERINE MODIFICATION%GOBP%GO:0018209	peptidyl-serine modification	0.0019307443276703425	0.0019307443276703425	+1	AKT1,ATM,MTOR,LRRK2,TGFBR2,TAF1,ATR
POSITIVE REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	0.0019307443276703425	0.0019307443276703425	+1	RUNX1,CBFB
MONOUBIQUITINATED HISTONE DEUBIQUITINATION%GOBP%GO:0035521	monoubiquitinated histone deubiquitination	0.0019307443276703425	0.0019307443276703425	+1	BAP1,ASXL1
OTIC VESICLE MORPHOGENESIS%GOBP%GO:0071600	otic vesicle morphogenesis	0.0019307443276703425	0.0019307443276703425	+1	SOX9,FGFR2
MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.1	MET activates PTPN11	0.0019307443276703425	0.0019307443276703425	+1	HGF,PTPN11
BRANCH ELONGATION OF AN EPITHELIUM%GOBP%GO:0060602	branch elongation of an epithelium	0.0019307443276703425	0.0019307443276703425	+1	SOX9,FGFR2
PROSTATE GLAND MORPHOGENESIS%GOBP%GO:0060512	prostate gland morphogenesis	0.0019307443276703425	0.0019307443276703425	+1	SOX9,FGFR2
MALE GENITALIA DEVELOPMENT%GOBP%GO:0030539	male genitalia development	0.0019307443276703425	0.0019307443276703425	+1	TBX3,WT1
POSITIVE REGULATION OF DNA BINDING%GOBP%GO:0043388	positive regulation of DNA binding	0.0019755382695796227	0.0019755382695796227	+1	GATA3,RB1,CTNNB1,EP300
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.2	Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer	0.0019755382695796227	0.0019755382695796227	+1	SMAD4,USP9X,NCOR1,SMAD2
CELLULAR RESPONSE TO OXIDATIVE STRESS%GOBP%GO:0034599	cellular response to oxidative stress	0.002036813744881315	0.002036813744881315	+1	TP53,EGFR,KEAP1,NFE2L2,AKT1,LRRK2,PDGFRA
OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.4	Oxidative Stress Induced Senescence	0.0020694732762970565	0.0020694732762970565	+1	TP53,CDKN2A,MAP2K4,HIST1H2BD,CDKN2C,EZH2
RESPONSE TO BMP%GOBP%GO:0071772	response to BMP	0.0020742196055599025	0.0020742196055599025	+1	SOX9,SMAD4,USP9X,ACVR2A,SMAD2
CELLULAR RESPONSE TO BMP STIMULUS%GOBP%GO:0071773	cellular response to BMP stimulus	0.0020742196055599025	0.0020742196055599025	+1	SOX9,SMAD4,USP9X,ACVR2A,SMAD2
REGULATION OF OSTEOBLAST DIFFERENTIATION%GOBP%GO:0045667	regulation of osteoblast differentiation	0.0020742196055599025	0.0020742196055599025	+1	NOTCH1,SOX9,HGF,FGFR2,ACVR2A
REGULATION OF PROTEIN UBIQUITINATION%GOBP%GO:0031396	regulation of protein ubiquitination	0.002097539973474751	0.002097539973474751	+1	PTEN,FBXW7,AKT1,BRCA1,LRRK2,TAF1,RPL5
EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING	EPHA2 forward signaling	0.0021257924349385	0.0021257924349385	+1	PIK3CA,PIK3R1,ARHGAP35
POSITIVE REGULATION OF LIPID METABOLIC PROCESS%GOBP%GO:0045834	positive regulation of lipid metabolic process	0.0021257924349385	0.0021257924349385	+1	FLT3,AKT1,MTOR,KIT,PDGFRA,FGFR3
BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY	BIOCARTA_CTLA4_PATHWAY	0.0021257924349385	0.0021257924349385	+1	PIK3CA,PIK3R1,PTPN11
REGULATION OF PRI-MIRNA TRANSCRIPTION BY RNA POLYMERASE II%GOBP%GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	0.0021257924349385	0.0021257924349385	+1	TP53,GATA3,SOX9,WT1
POSITIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	0.0021257924349385	0.0021257924349385	+1	EGFR,AKT1,CCND1
PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY	PID_EPHA2_FWD_PATHWAY	0.0021257924349385	0.0021257924349385	+1	PIK3CA,PIK3R1,ARHGAP35
HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0021257924349385	0.0021257924349385	+1	TP53,VHL,CDKN2A
PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY	PID_HIF1A_PATHWAY	0.0021257924349385	0.0021257924349385	+1	TP53,VHL,CDKN2A
GENITALIA DEVELOPMENT%GOBP%GO:0048806	genitalia development	0.0021257924349385	0.0021257924349385	+1	TBX3,WT1,PTPN11
NEGATIVE REGULATION OF ANIMAL ORGAN MORPHOGENESIS%GOBP%GO:0110111	negative regulation of animal organ morphogenesis	0.0021257924349385	0.0021257924349385	+1	GATA3,NOTCH1,FBXW7
BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY	BIOCARTA_TID_PATHWAY	0.0021257924349385	0.0021257924349385	+1	TP53,RB1,WT1
REGULATION OF CELL-CELL ADHESION MEDIATED BY CADHERIN%GOBP%GO:2000047	regulation of cell-cell adhesion mediated by cadherin	0.0021257924349385	0.0021257924349385	+1	NOTCH1,FOXA1,FOXA2
G-CSF%IOB%G-CSF	G-CSF	0.0021257924349385	0.0021257924349385	+1	NOTCH1,AKT1,CDKN1B,PTPN11
REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING	Regulation of cytoplasmic and nuclear SMAD2 3 signaling	0.0021257924349385	0.0021257924349385	+1	MAP3K1,SMAD4,SMAD2
PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY	PID_INSULIN_PATHWAY	0.0021257924349385	0.0021257924349385	+1	PIK3CA,PIK3R1,AKT1,PTPN11
BONE DEVELOPMENT%GOBP%GO:0060348	bone development	0.0021561190627319557	0.0021561190627319557	+1	TP53,SOX9,KIT,FGFR2,FGFR3
RESPONSE TO ALCOHOL%GOBP%GO:0097305	response to alcohol	0.002257701859960232	0.002257701859960232	+1	CTNNB1,CDH1,BRCA1,TGFBR2,SMAD2
PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY	PID_PS1_PATHWAY	0.002257701859960232	0.002257701859960232	+1	APC,NOTCH1,CTNNB1,CCND1
CHORDATE EMBRYONIC DEVELOPMENT%GOBP%GO:0043009	chordate embryonic development	0.002257701859960232	0.002257701859960232	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
T CELL COSTIMULATION%GOBP%GO:0031295	T cell costimulation	0.002257701859960232	0.002257701859960232	+1	PIK3CA,PIK3R1,AKT1,PTPN11
BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY	BIOCARTA_KERATINOCYTE_PATHWAY	0.002257701859960232	0.002257701859960232	+1	EGFR,MAP3K1,MAP2K4,CEBPA
HOMEOSTASIS OF NUMBER OF CELLS%GOBP%GO:0048872	homeostasis of number of cells	0.002257701859960232	0.002257701859960232	+1	NOTCH1,FLT3,AKT1,SOX9,KIT
PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING	Presenilin action in Notch and Wnt signaling	0.002257701859960232	0.002257701859960232	+1	APC,NOTCH1,CTNNB1,CCND1
GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK	Glucocorticoid receptor regulatory network	0.002257701859960232	0.002257701859960232	+1	TP53,GATA3,AKT1,EP300,CDKN1A
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.3	NOTCH1 Intracellular Domain Regulates Transcription	0.002257701859960232	0.002257701859960232	+1	NOTCH1,EP300,TBL1XR1,NCOR1
CELLULAR RESPONSE TO IONIZING RADIATION%GOBP%GO:0071479	cellular response to ionizing radiation	0.002257701859960232	0.002257701859960232	+1	TP53,ATM,CDKN1A,ATR
CARDIAC SEPTUM MORPHOGENESIS%GOBP%GO:0060411	cardiac septum morphogenesis	0.002257701859960232	0.002257701859960232	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY	PID_REG_GR_PATHWAY	0.002257701859960232	0.002257701859960232	+1	TP53,GATA3,AKT1,EP300,CDKN1A
ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20200810%WP4535%HOMO SAPIENS	Envelope proteins and their potential roles in EDMD physiopathology	0.002257701859960232	0.002257701859960232	+1	KRAS,NRAS,SMAD4,SMAD2
POSITIVE REGULATION OF BINDING%GOBP%GO:0051099	positive regulation of binding	0.0023625323282714613	0.0023625323282714613	+1	GATA3,RB1,CTNNB1,LRRK2,EP300,TAF1
SISTER CHROMATID SEGREGATION%GOBP%GO:0000819	sister chromatid segregation	0.0023625323282714613	0.0023625323282714613	+1	RB1,FBXW7,STAG2,SMC1A,SMC3,RAD21
CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.3	Cyclin E associated events during G1 S transition	0.0023718863093455888	0.0023718863093455888	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
DIGESTIVE TRACT MORPHOGENESIS%GOBP%GO:0048546	digestive tract morphogenesis	0.00239851076467018	0.00239851076467018	+1	PDGFRA,FGFR2,SOX17
THYMIC STROMAL LYMPHOPOIETIN (TSLP) SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP2203%HOMO SAPIENS	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway	0.00239851076467018	0.00239851076467018	+1	PIK3CA,AKT1,MTOR,PTPN11
NEGATIVE REGULATION OF COLD-INDUCED THERMOGENESIS%GOBP%GO:0120163	negative regulation of cold-induced thermogenesis	0.00239851076467018	0.00239851076467018	+1	RB1,NOTCH1,STK11,TLR4
DETERMINATION OF HEART LEFT/RIGHT ASYMMETRY%GOBP%GO:0061371	determination of heart left/right asymmetry	0.00239851076467018	0.00239851076467018	+1	NOTCH1,TBX3,TGFBR2,SOX17
REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION%GOBP%GO:0060043	regulation of cardiac muscle cell proliferation	0.00239851076467018	0.00239851076467018	+1	NOTCH1,ERBB4,FGFR2
REGULATION OF CELLULAR RESPONSE TO DRUG%GOBP%GO:2001038	regulation of cellular response to drug	0.00239851076467018	0.00239851076467018	+1	NFE2L2,HGF,LRRK2
MAMMARY GLAND EPITHELIUM DEVELOPMENT%GOBP%GO:0061180	mammary gland epithelium development	0.00239851076467018	0.00239851076467018	+1	AKT1,ERBB4,FGFR2
FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY	Fanconi anemia pathway	0.00239851076467018	0.00239851076467018	+1	ATM,BRCA1,BRCA2,ATR
MITOTIC SPINDLE ASSEMBLY%GOBP%GO:0090307	mitotic spindle assembly	0.00239851076467018	0.00239851076467018	+1	STAG2,CHEK2,SMC1A,SMC3
CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS%GOBP%GO:0031668	cellular response to extracellular stimulus	0.00239851076467018	0.00239851076467018	+1	TP53,ARHGAP35,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY	PID_FANCONI_PATHWAY	0.00239851076467018	0.00239851076467018	+1	ATM,BRCA1,BRCA2,ATR
HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20200810%WP4206%HOMO SAPIENS	Hereditary leiomyomatosis and renal cell carcinoma pathway	0.00239851076467018	0.00239851076467018	+1	TP53,KEAP1,NFE2L2
REGULATION OF ACTIVIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0032925	regulation of activin receptor signaling pathway	0.00239851076467018	0.00239851076467018	+1	ACVR1B,ACVR2A,SMAD2
ATRIOVENTRICULAR VALVE MORPHOGENESIS%GOBP%GO:0003181	atrioventricular valve morphogenesis	0.00239851076467018	0.00239851076467018	+1	NOTCH1,SMAD4,TGFBR2
EMBRYONIC HEART TUBE MORPHOGENESIS%GOBP%GO:0003143	embryonic heart tube morphogenesis	0.00239851076467018	0.00239851076467018	+1	NOTCH1,TBX3,TGFBR2,SOX17
CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 73%389513	CTLA4 inhibitory signaling	0.00239851076467018	0.00239851076467018	+1	AKT1,PPP2R1A,PTPN11
PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY	PID_LKB1_PATHWAY	0.00239851076467018	0.00239851076467018	+1	TP53,STK11,MTOR,SMAD4
NEGATIVE REGULATION OF RESPONSE TO DRUG%GOBP%GO:2001024	negative regulation of response to drug	0.00239851076467018	0.00239851076467018	+1	NFE2L2,HGF,LRRK2
REGULATION OF OSSIFICATION%GOBP%GO:0030278	regulation of ossification	0.002411143162220759	0.002411143162220759	+1	NOTCH1,SOX9,HGF,FGFR2,PTPN11,ACVR2A
RANKL%NETPATH%RANKL	RANKL	0.0024535942427840597	0.0024535942427840597	+1	EGFR,PIK3R1,RUNX1,AKT1,MTOR
CELLULAR RESPONSE TO METAL ION%GOBP%GO:0071248	cellular response to metal ion	0.0025077477466077065	0.0025077477466077065	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY%GOBP%GO:0031334	positive regulation of protein complex assembly	0.002562406689804563	0.002562406689804563	+1	TP53,NAV3,CTNNB1,AJUBA,ATM,TLR4,ATR,ERCC2
RETT SYNDROME CAUSING GENES%WIKIPATHWAYS_20200810%WP4312%HOMO SAPIENS	Rett syndrome causing genes	0.002563049484824515	0.002563049484824515	+1	BRAF,SMC1A,TBL1XR1,NCOR1
PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY	PID_HEDGEHOG_GLI_PATHWAY	0.002563049484824515	0.002563049484824515	+1	AKT1,FOXA2,SIN3A,SPOP
CELLULAR RESPONSE TO MECHANICAL STIMULUS%GOBP%GO:0071260	cellular response to mechanical stimulus	0.002563049484824515	0.002563049484824515	+1	MAP3K1,MAP2K4,SOX9,TLR4
HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS	Hedgehog signaling events mediated by Gli proteins	0.002563049484824515	0.002563049484824515	+1	AKT1,FOXA2,SIN3A,SPOP
LYMPHOCYTE COSTIMULATION%GOBP%GO:0031294	lymphocyte costimulation	0.002563049484824515	0.002563049484824515	+1	PIK3CA,PIK3R1,AKT1,PTPN11
CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 73%69656	Cyclin A:Cdk2-associated events at S phase entry	0.002563049484824515	0.002563049484824515	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20200810%WP2873%HOMO SAPIENS	Aryl Hydrocarbon Receptor Pathway	0.002563049484824515	0.002563049484824515	+1	EGFR,NFE2L2,CDKN1B,EP300
BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE%GOBP%GO:0048754	branching morphogenesis of an epithelial tube	0.002563049484824515	0.002563049484824515	+1	CTNNB1,WT1,FGFR2,TGFBR2
PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY	PID_CERAMIDE_PATHWAY	0.002563049484824515	0.002563049484824515	+1	RB1,MAP3K1,MAP2K4,AKT1
FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING	FoxO family signaling	0.002563049484824515	0.002563049484824515	+1	CTNNB1,AKT1,CDKN1B,EP300
SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION%GOBP%GO:0007264	small GTPase mediated signal transduction	0.0026508731797433706	0.0026508731797433706	+1	TP53,KRAS,NF1,CDKN2A,RB1,NRAS,CDKN1A
G1 S TRANSITION%REACTOME DATABASE ID RELEASE 73%69206	G1 S Transition	0.0026815031570630657	0.0026815031570630657	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A
EBOLA VIRUS PATHWAY ON HOST%WIKIPATHWAYS_20200810%WP4217%HOMO SAPIENS	Ebola Virus Pathway on Host	0.0026815031570630657	0.0026815031570630657	+1	PIK3CA,EGFR,PIK3R1,AKT1,TLR4,EP300
REGULATION OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE%GOBP%GO:1903076	regulation of protein localization to plasma membrane	0.0026887362626519438	0.0026887362626519438	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY	PDGFR-alpha signaling pathway	0.0027063106234013383	0.0027063106234013383	+1	PIK3CA,PIK3R1,PDGFRA
REGULATION OF HISTONE H3-K4 METHYLATION%GOBP%GO:0051569	regulation of histone H3-K4 methylation	0.0027063106234013383	0.0027063106234013383	+1	CTNNB1,BRCA1,SMAD4
ACTIVIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0032924	activin receptor signaling pathway	0.0027063106234013383	0.0027063106234013383	+1	ACVR1B,ACVR2A,SMAD2
REGULATION OF PRODUCTION OF SMALL RNA INVOLVED IN GENE SILENCING BY RNA%GOBP%GO:0070920	regulation of production of small RNA involved in gene silencing by RNA	0.0027063106234013383	0.0027063106234013383	+1	TP53,EGFR,NCOR1
IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20200810%WP3640%HOMO SAPIENS	Imatinib and Chronic Myeloid Leukemia	0.0027063106234013383	0.0027063106234013383	+1	CDKN1B,KIT,PDGFRA
P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397	p53 pathway by glucose deprivation	0.0027063106234013383	0.0027063106234013383	+1	TP53,STK11,AKT1
REGULATION OF PRODUCTION OF MIRNAS INVOLVED IN GENE SILENCING BY MIRNA%GOBP%GO:1903798	regulation of production of miRNAs involved in gene silencing by miRNA	0.0027063106234013383	0.0027063106234013383	+1	TP53,EGFR,NCOR1
POSITIVE REGULATION OF NEURON DEATH%GOBP%GO:1901216	positive regulation of neuron death	0.0027287717622840207	0.0027287717622840207	+1	NF1,FBXW7,CTNNB1,TLR4
REGULATION OF GLUCOSE TRANSMEMBRANE TRANSPORT%GOBP%GO:0010827	regulation of glucose transmembrane transport	0.0027287717622840207	0.0027287717622840207	+1	PIK3R1,AKT1,BRAF,PTPN11
HISTONE LYSINE METHYLATION%GOBP%GO:0034968	histone lysine methylation	0.0027287717622840207	0.0027287717622840207	+1	KDM6A,TET2,SETD2,EZH2
PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY	PID_FOXO_PATHWAY	0.0027287717622840207	0.0027287717622840207	+1	CTNNB1,AKT1,CDKN1B,EP300
REGULATION OF MICROTUBULE CYTOSKELETON%WIKIPATHWAYS_20200810%WP2038%HOMO SAPIENS	Regulation of Microtubule Cytoskeleton	0.0027287717622840207	0.0027287717622840207	+1	PIK3CA,PTEN,APC,AKT1
ISOCITRATE METABOLIC PROCESS%GOBP%GO:0006102	isocitrate metabolic process	0.0028707983446536974	0.0028707983446536974	+1	IDH1,IDH2
DETERMINATION OF ADULT LIFESPAN%GOBP%GO:0008340	determination of adult lifespan	0.0028707983446536974	0.0028707983446536974	+1	TP53,LRRK2
ENDOCARDIUM MORPHOGENESIS%GOBP%GO:0003160	endocardium morphogenesis	0.0028707983446536974	0.0028707983446536974	+1	NOTCH1,SOX17
POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA%GOBP%GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.0028707983446536974	0.0028707983446536974	+1	NOTCH1,NFE2L2
POSITIVE REGULATION OF HISTONE H3-K9 ACETYLATION%GOBP%GO:2000617	positive regulation of histone H3-K9 acetylation	0.0028707983446536974	0.0028707983446536974	+1	BRCA1,SMAD4
MEMBRANOUS SEPTUM MORPHOGENESIS%GOBP%GO:0003149	membranous septum morphogenesis	0.0028707983446536974	0.0028707983446536974	+1	FGFR2,TGFBR2
FOREBRAIN MORPHOGENESIS%GOBP%GO:0048853	forebrain morphogenesis	0.0028707983446536974	0.0028707983446536974	+1	PTEN,NF1
PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS	PLK3 signaling events	0.0028707983446536974	0.0028707983446536974	+1	TP53,CHEK2
POSITIVE REGULATION OF OXIDATIVE STRESS-INDUCED NEURON DEATH%GOBP%GO:1903223	positive regulation of oxidative stress-induced neuron death	0.0028707983446536974	0.0028707983446536974	+1	FBXW7,TLR4
LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-HSA-3134973.1	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.0028707983446536974	0.0028707983446536974	+1	CTNNB1,EP300
RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME%R-HSA-8935964.1	RUNX1 regulates expression of components of tight junctions	0.0028707983446536974	0.0028707983446536974	+1	RUNX1,CBFB
TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 73%3656532	TGFBR1 KD Mutants in Cancer	0.0028707983446536974	0.0028707983446536974	+1	TGFBR2,SMAD2
NEGATIVE REGULATION OF CELL PROLIFERATION INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:1901723	negative regulation of cell proliferation involved in kidney development	0.0028707983446536974	0.0028707983446536974	+1	GATA3,WT1
SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%R-HSA-3304356.2	SMAD2 3 Phosphorylation Motif Mutants in Cancer	0.0028707983446536974	0.0028707983446536974	+1	TGFBR2,SMAD2
EMBRYONIC SKELETAL SYSTEM DEVELOPMENT%GOBP%GO:0048706	embryonic skeletal system development	0.002900841807335963	0.002900841807335963	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
AXIS SPECIFICATION%GOBP%GO:0009798	axis specification	0.002900841807335963	0.002900841807335963	+1	TBX3,WT1,FOXA2,SMAD2
REGULATION OF INTRACELLULAR PROTEIN TRANSPORT%GOBP%GO:0033157	regulation of intracellular protein transport	0.0029198494466333657	0.0029198494466333657	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,LRRK2,SETD2
REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS%GOBP%GO:2000377	regulation of reactive oxygen species metabolic process	0.002928272605377391	0.002928272605377391	+1	TP53,AKT1,TLR4,BRCA1,TGFBR2,CDKN1A
POSITIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN KINASE ACTIVITY%GOBP%GO:1904031	positive regulation of cyclin-dependent protein kinase activity	0.003007333556334249	0.003007333556334249	+1	EGFR,AKT1,CCND1
POSITIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS%GOBP%GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus	0.003007333556334249	0.003007333556334249	+1	STK11,EP300,SMAD4
POSITIVE REGULATION OF MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:1905332	positive regulation of morphogenesis of an epithelium	0.003007333556334249	0.003007333556334249	+1	GATA3,SOX9,MTOR
BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY	BIOCARTA_CHEMICAL_PATHWAY	0.003007333556334249	0.003007333556334249	+1	TP53,AKT1,ATM
PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY	PID_PDGFRA_PATHWAY	0.003007333556334249	0.003007333556334249	+1	PIK3CA,PIK3R1,PDGFRA
POSITIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY%GOBP%GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	0.003007333556334249	0.003007333556334249	+1	STK11,EP300,SMAD4
PI3K/AKT/MTOR - VITD3 SIGNALLING%WIKIPATHWAYS_20200810%WP4141%HOMO SAPIENS	PI3K/AKT/mTOR - VitD3 Signalling	0.003007333556334249	0.003007333556334249	+1	PIK3CA,AKT1,MTOR
PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY	PID_HEDGEHOG_2PATHWAY	0.003007333556334249	0.003007333556334249	+1	PIK3CA,PIK3R1,AKT1
ATRIOVENTRICULAR VALVE DEVELOPMENT%GOBP%GO:0003171	atrioventricular valve development	0.003007333556334249	0.003007333556334249	+1	NOTCH1,SMAD4,TGFBR2
CCR7%IOB%CCR7	CCR7	0.003007333556334249	0.003007333556334249	+1	MAP2K4,AKT1,MTOR
SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY	Signaling events mediated by the Hedgehog family	0.003007333556334249	0.003007333556334249	+1	PIK3CA,PIK3R1,AKT1
POSITIVE REGULATION OF BMP SIGNALING PATHWAY%GOBP%GO:0030513	positive regulation of BMP signaling pathway	0.003007333556334249	0.003007333556334249	+1	NOTCH1,SMAD4,SMAD2
NCRNAS INVOLVED IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20200810%WP4336%HOMO SAPIENS	ncRNAs involved in Wnt signaling in hepatocellular carcinoma	0.003011642958131342	0.003011642958131342	+1	APC,CTNNB1,CCND1,SOX17,EZH2
POSITIVE REGULATION OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE%GOBP%GO:1903078	positive regulation of protein localization to plasma membrane	0.0030732072809610154	0.0030732072809610154	+1	EGFR,PIK3R1,EPHA3,AKT1
APOPTOTIC EXECUTION PHASE%REACTOME%R-HSA-75153.4	Apoptotic execution phase	0.0030732072809610154	0.0030732072809610154	+1	APC,CTNNB1,CDH1,HIST1H1C
TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING	TGF-beta receptor signaling	0.0030732072809610154	0.0030732072809610154	+1	CTNNB1,SMAD4,TGFBR2,SMAD2
CELLULAR RESPONSE TO HYPOXIA%GOBP%GO:0071456	cellular response to hypoxia	0.0031128529781275353	0.0031128529781275353	+1	TP53,VHL,NOTCH1,NFE2L2,MTOR,EP300
REGULATION OF LIPASE ACTIVITY%GOBP%GO:0060191	regulation of lipase activity	0.003153687751003553	0.003153687751003553	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
PTEN REGULATION%REACTOME%R-HSA-6807070.2	PTEN Regulation	0.003228825983456911	0.003228825983456911	+1	TP53,PTEN,AKT1,MTOR,MECOM,EZH2
EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING%GOBP%GO:0009792	embryo development ending in birth or egg hatching	0.003243661663211581	0.003243661663211581	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B	Signaling events mediated by PTP1B	0.0032771151574859225	0.0032771151574859225	+1	PIK3CA,EGFR,PIK3R1,AKT1
PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY	PID_PTP1B_PATHWAY	0.0032771151574859225	0.0032771151574859225	+1	PIK3CA,EGFR,PIK3R1,AKT1
NETRIN-UNC5B SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP4747%HOMO SAPIENS	Netrin-UNC5B signaling Pathway	0.0032771151574859225	0.0032771151574859225	+1	TP53,PIK3CA,AKT1,PTPN11
EMBRYONIC HEART TUBE DEVELOPMENT%GOBP%GO:0035050	embryonic heart tube development	0.0032771151574859225	0.0032771151574859225	+1	NOTCH1,TBX3,TGFBR2,SOX17
ENDOCRINE SYSTEM DEVELOPMENT%GOBP%GO:0035270	endocrine system development	0.0032771151574859225	0.0032771151574859225	+1	NF1,AKT1,WT1,FOXA2
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 73%1660499	Synthesis of PIPs at the plasma membrane	0.0032771151574859225	0.0032771151574859225	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
CARDIAC MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0048738	cardiac muscle tissue development	0.003287414662982652	0.003287414662982652	+1	NOTCH1,WT1,PDGFRA,FGFR2,SMAD4
HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.2	Homology Directed Repair	0.0033250246050416776	0.0033250246050416776	+1	ATM,BRCA1,POLQ,BRCA2,ATR,HIST1H2BD
NRF2-ARE REGULATION%WIKIPATHWAYS_20200810%WP4357%HOMO SAPIENS	NRF2-ARE regulation	0.0033554327605952276	0.0033554327605952276	+1	PIK3CA,KEAP1,NFE2L2
GDNF/RET SIGNALLING AXIS%WIKIPATHWAYS_20200810%WP4830%HOMO SAPIENS	GDNF/RET signalling axis	0.0033554327605952276	0.0033554327605952276	+1	GATA3,CTNNB1,SOX17
RESPONSE TO OXIDATIVE STRESS%GOBP%GO:0006979	response to oxidative stress	0.0033554327605952276	0.0033554327605952276	+1	TP53,EGFR,KEAP1,NFE2L2,AKT1,LRRK2,PDGFRA,ERCC2
POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0055025	positive regulation of cardiac muscle tissue development	0.0033554327605952276	0.0033554327605952276	+1	NOTCH1,ERBB4,FGFR2
BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY	BIOCARTA_IGF1R_PATHWAY	0.0033554327605952276	0.0033554327605952276	+1	PIK3CA,PIK3R1,AKT1
ESTROGEN SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP712%HOMO SAPIENS	Estrogen signaling pathway	0.0033554327605952276	0.0033554327605952276	+1	PIK3CA,AKT1,BRAF
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 73%8940973	RUNX2 regulates osteoblast differentiation	0.0033554327605952276	0.0033554327605952276	+1	RB1,AR,CBFB
NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 73%5654732	Negative regulation of FGFR3 signaling	0.0033554327605952276	0.0033554327605952276	+1	BRAF,PPP2R1A,PTPN11
RESPONSE TO GAMMA RADIATION%GOBP%GO:0010332	response to gamma radiation	0.0033554327605952276	0.0033554327605952276	+1	TP53,ATM,ATR
CELLULAR RESPONSE TO DECREASED OXYGEN LEVELS%GOBP%GO:0036294	cellular response to decreased oxygen levels	0.0034199124638666714	0.0034199124638666714	+1	TP53,VHL,NOTCH1,NFE2L2,MTOR,EP300
PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY	PID_AR_TF_PATHWAY	0.0034725022148774745	0.0034725022148774745	+1	MAP2K4,CEBPA,AR,EP300
REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY	Regulation of Androgen receptor activity	0.0034725022148774745	0.0034725022148774745	+1	MAP2K4,CEBPA,AR,EP300
BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY	BIOCARTA_NFAT_PATHWAY	0.0034725022148774745	0.0034725022148774745	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
REGULATION OF MICROTUBULE-BASED PROCESS%GOBP%GO:0032886	regulation of microtubule-based process	0.0034789243425378392	0.0034789243425378392	+1	APC,NAV3,CTNNB1,NPM1,STK11,EPHA3,BRCA1
REGULATION OF LEUKOCYTE DIFFERENTIATION%GOBP%GO:1902105	regulation of leukocyte differentiation	0.0034789243425378392	0.0034789243425378392	+1	GATA3,FBXW7,RUNX1,MTOR,TLR4,TGFBR2,CBFB
FOREBRAIN DEVELOPMENT%GOBP%GO:0030900	forebrain development	0.003664339906193764	0.003664339906193764	+1	PTEN,NF1,ERBB4,LRRK2,FGFR2,SIN3A
PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY	PID_RAC1_PATHWAY	0.003706627754631605	0.003706627754631605	+1	CTNNB1,MAP3K1,CDH1,MAP2K4
RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY	RAC1 signaling pathway	0.003706627754631605	0.003706627754631605	+1	CTNNB1,MAP3K1,CDH1,MAP2K4
NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH%GOBP%GO:0048640	negative regulation of developmental growth	0.003706627754631605	0.003706627754631605	+1	PTEN,CDKN1B,FGFR3,CDKN1A
TNF ALPHA SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP231%HOMO SAPIENS	TNF alpha Signaling Pathway	0.0037292918511039413	0.0037292918511039413	+1	KRAS,MAP3K1,NRAS,MAP2K4,AKT1
REGULATION OF CELLULAR CARBOHYDRATE METABOLIC PROCESS%GOBP%GO:0010675	regulation of cellular carbohydrate metabolic process	0.0037292918511039413	0.0037292918511039413	+1	TP53,AKT1,EP300,FOXA2,NCOR1
GLAND MORPHOGENESIS%GOBP%GO:0022612	gland morphogenesis	0.0037334162510880868	0.0037334162510880868	+1	SOX9,ELF3,FGFR2
BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY	BIOCARTA_TPO_PATHWAY	0.0037334162510880868	0.0037334162510880868	+1	PIK3CA,PIK3R1,PIK3CG
POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS%GOBP%GO:0043525	positive regulation of neuron apoptotic process	0.0037334162510880868	0.0037334162510880868	+1	NF1,FBXW7,CTNNB1
IL9%NETPATH%IL9	IL9	0.0037334162510880868	0.0037334162510880868	+1	PIK3R1,AKT1,PTPN11
OUTFLOW TRACT SEPTUM MORPHOGENESIS%GOBP%GO:0003148	outflow tract septum morphogenesis	0.0037334162510880868	0.0037334162510880868	+1	FGFR2,SMAD4,TGFBR2
POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO STRESS%GOBP%GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	0.0037334162510880868	0.0037334162510880868	+1	TP53,NOTCH1,NFE2L2
BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY	BIOCARTA_NTHI_PATHWAY	0.0037334162510880868	0.0037334162510880868	+1	EP300,SMAD4,TGFBR2
REGULATION OF CARDIAC MUSCLE TISSUE GROWTH%GOBP%GO:0055021	regulation of cardiac muscle tissue growth	0.0037334162510880868	0.0037334162510880868	+1	NOTCH1,ERBB4,FGFR2
DOPAMINERGIC NEURON DIFFERENTIATION%GOBP%GO:0071542	dopaminergic neuron differentiation	0.0037334162510880868	0.0037334162510880868	+1	CTNNB1,FOXA1,FOXA2
BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY	BIOCARTA_ECM_PATHWAY	0.0037334162510880868	0.0037334162510880868	+1	PIK3CA,PIK3R1,PIK3CG
REGULATION OF CELL CYCLE G2/M PHASE TRANSITION%GOBP%GO:1902749	regulation of cell cycle G2/M phase transition	0.003747875744862481	0.003747875744862481	+1	TP53,NPM1,ATM,BRCA1,CCND1,CDKN1A,PPP2R1A
CXCR4%IOB%CXCR4	CXCR4	0.00386423446643141	0.00386423446643141	+1	EGFR,PIK3R1,CTNNB1,AKT1,PTPN11
THYROID HORMONES PRODUCTION AND THEIR PERIPHERAL DOWNSTREAM SIGNALLING EFFECTS REGARDING CONGENITAL HYPOTHYROIDISM%WIKIPATHWAYS_20200810%WP4746%HOMO SAPIENS	Thyroid hormones production and their peripheral downstream signalling effects regarding congenital hypothyroidism	0.00386423446643141	0.00386423446643141	+1	TP53,PIK3CA,NOTCH1,CTNNB1,MTOR
POSITIVE REGULATION OF HEMOPOIESIS%GOBP%GO:1903708	positive regulation of hemopoiesis	0.003865764288168203	0.003865764288168203	+1	GATA3,RUNX1,TGFBR2,CBFB,ACVR1B,ACVR2A
REGULATION OF TOLL-LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP1449%HOMO SAPIENS	Regulation of toll-like receptor signaling pathway	0.003865764288168203	0.003865764288168203	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PIK3CG,TLR4
MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0060537	muscle tissue development	0.003865764288168203	0.003865764288168203	+1	NF1,NOTCH1,WT1,PDGFRA,FGFR2,SMAD4
INTERFERON TYPE I SIGNALING PATHWAYS%WIKIPATHWAYS_20200810%WP585%HOMO SAPIENS	Interferon type I signaling pathways	0.0038949670048347893	0.0038949670048347893	+1	PIK3R1,MAP3K1,MTOR,PTPN11
PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY	PID_TGFBR_PATHWAY	0.0038949670048347893	0.0038949670048347893	+1	CTNNB1,SMAD4,TGFBR2,SMAD2
TRAIL%IOB%TRAIL	TRAIL	0.0038949670048347893	0.0038949670048347893	+1	CTNNB1,AKT1,ATM,CHEK2
REGULATION OF MESENCHYMAL STEM CELL DIFFERENTIATION%GOBP%GO:2000739	regulation of mesenchymal stem cell differentiation	0.003911918092243952	0.003911918092243952	+1	SOX9,PDGFRA
NEGATIVE REGULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL%GOBP%GO:0090394	negative regulation of excitatory postsynaptic potential	0.003911918092243952	0.003911918092243952	+1	PTEN,LRRK2
LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 73%3656534	Loss of Function of TGFBR1 in Cancer	0.003911918092243952	0.003911918092243952	+1	TGFBR2,SMAD2
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 73%8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	0.003911918092243952	0.003911918092243952	+1	RUNX1,CBFB
ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME%R-HSA-9028335.1	Activated NTRK2 signals through PI3K	0.003911918092243952	0.003911918092243952	+1	PIK3CA,PIK3R1
POSITIVE REGULATION OF MALE GONAD DEVELOPMENT%GOBP%GO:2000020	positive regulation of male gonad development	0.003911918092243952	0.003911918092243952	+1	SOX9,WT1
ATRIOVENTRICULAR CANAL DEVELOPMENT%GOBP%GO:0036302	atrioventricular canal development	0.003911918092243952	0.003911918092243952	+1	SMAD4,PTPN11
PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 73%8849470	PTK6 Regulates Cell Cycle	0.003911918092243952	0.003911918092243952	+1	CDKN1B,CCND1
LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 73%9022537	Loss of MECP2 binding ability to the NCoR SMRT complex	0.003911918092243952	0.003911918092243952	+1	TBL1XR1,NCOR1
REGULATION OF PROTEIN AUTOUBIQUITINATION%GOBP%GO:1902498	regulation of protein autoubiquitination	0.003911918092243952	0.003911918092243952	+1	LRRK2,TAF1
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.1	RUNX1 regulates transcription of genes involved in WNT signaling	0.003911918092243952	0.003911918092243952	+1	RUNX1,CBFB
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 73%8939245	RUNX1 regulates transcription of genes involved in BCR signaling	0.003911918092243952	0.003911918092243952	+1	RUNX1,CBFB
STAT5 ACTIVATION%REACTOME DATABASE ID RELEASE 73%9645135	STAT5 Activation	0.003911918092243952	0.003911918092243952	+1	FLT3,PTPN11
ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-HSA-9603381.1	Activated NTRK3 signals through PI3K	0.003911918092243952	0.003911918092243952	+1	PIK3CA,PIK3R1
OTIC VESICLE DEVELOPMENT%GOBP%GO:0071599	otic vesicle development	0.003911918092243952	0.003911918092243952	+1	SOX9,FGFR2
GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.1	Genome Replication and Transcription	0.003911918092243952	0.003911918092243952	+1	VHL,RB1
REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.1	Replication of the SARS-CoV-1 genome	0.003911918092243952	0.003911918092243952	+1	VHL,RB1
REGULATION OF WOUND HEALING, SPREADING OF EPIDERMAL CELLS%GOBP%GO:1903689	regulation of wound healing, spreading of epidermal cells	0.003911918092243952	0.003911918092243952	+1	PTEN,MTOR
RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 73%6802953	RAS signaling downstream of NF1 loss-of-function variants	0.003911918092243952	0.003911918092243952	+1	NF1,NRAS
PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 73%8857538	PTK6 promotes HIF1A stabilization	0.003911918092243952	0.003911918092243952	+1	EGFR,LRRK2
REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation	0.003911918092243952	0.003911918092243952	+1	RUNX1,CBFB
RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 73%8931987	RUNX1 regulates estrogen receptor mediated transcription	0.003911918092243952	0.003911918092243952	+1	RUNX1,CBFB
REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY%GOBP%GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.0039431731520050625	0.0039431731520050625	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
NEGATIVE REGULATION OF MITOTIC SISTER CHROMATID SEGREGATION%GOBP%GO:0033048	negative regulation of mitotic sister chromatid segregation	0.004068067931274396	0.004068067931274396	+1	APC,ATM,ATRX
REGULATION OF EPITHELIAL CELL MIGRATION%GOBP%GO:0010632	regulation of epithelial cell migration	0.004068067931274396	0.004068067931274396	+1	PTEN,NF1,GATA3,NOTCH1,AKT1,SOX9,MTOR
EMBRYONIC AXIS SPECIFICATION%GOBP%GO:0000578	embryonic axis specification	0.004068067931274396	0.004068067931274396	+1	TBX3,WT1,SMAD2
HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20200810%WP3668%HOMO SAPIENS	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease	0.004068067931274396	0.004068067931274396	+1	SMAD4,TGFBR2,SMAD2
DAP12 SIGNALING%REACTOME%R-HSA-2424491.2	DAP12 signaling	0.004068067931274396	0.004068067931274396	+1	PIK3CA,PIK3R1,NRAS
PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY	PID_HDAC_CLASSIII_PATHWAY	0.004068067931274396	0.004068067931274396	+1	TP53,EP300,CDKN1A
MACROMOLECULE METHYLATION%GOBP%GO:0043414	macromolecule methylation	0.004068067931274396	0.004068067931274396	+1	DNMT3A,KDM6A,TET2,ATRX,SETD2,NSD1,EZH2
REGULATION OF OXIDATIVE STRESS-INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.004068067931274396	0.004068067931274396	+1	FBXW7,NFE2L2,AKT1
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.1	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	0.0040981144864615845	0.0040981144864615845	+1	RUNX1,EP300,CBFB,SIN3A,HIST1H2BD
CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%R-HSA-2644606.1	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.004280272222120944	0.004280272222120944	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS%GOBP%GO:2001020	regulation of response to DNA damage stimulus	0.004280272222120944	0.004280272222120944	+1	EGFR,ATM,BRCA1,POLQ,SETD2,ATR,AXIN2
MITOTIC NUCLEAR DIVISION%GOBP%GO:0140014	mitotic nuclear division	0.004280272222120944	0.004280272222120944	+1	RB1,STAG2,CHEK2,SMC1A,SMC3,RAD21
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2644602.1	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.004280272222120944	0.004280272222120944	+1	NOTCH1,EP300,TBL1XR1,NCOR1
B CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP23%HOMO SAPIENS	B Cell Receptor Signaling Pathway	0.004280272222120944	0.004280272222120944	+1	PIK3R1,AKT1,BRAF,PIK3CG,PTPN11
SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2894858.1	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.004280272222120944	0.004280272222120944	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS%GOBP%GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	0.004280272222120944	0.004280272222120944	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.1	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.004280272222120944	0.004280272222120944	+1	NOTCH1,EP300,TBL1XR1,NCOR1
SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.2	Signaling by NOTCH1 in Cancer	0.004280272222120944	0.004280272222120944	+1	NOTCH1,EP300,TBL1XR1,NCOR1
STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 73%69541	Stabilization of p53	0.004280272222120944	0.004280272222120944	+1	TP53,CDKN2A,ATM,CHEK2
REGULATION OF DNA BIOSYNTHETIC PROCESS%GOBP%GO:2000278	regulation of DNA biosynthetic process	0.004280272222120944	0.004280272222120944	+1	TP53,ATM,HGF,CDKN1A,ATR
POSITIVE REGULATION OF PROTEIN LOCALIZATION TO CELL PERIPHERY%GOBP%GO:1904377	positive regulation of protein localization to cell periphery	0.004280272222120944	0.004280272222120944	+1	EGFR,PIK3R1,EPHA3,AKT1
CIRCADIAN RHYTHM%GOBP%GO:0007623	circadian rhythm	0.004440123618882991	0.004440123618882991	+1	TP53,PTEN,EP300,EGR3,NCOR1
3-PHOSPHOINOSITIDE BIOSYNTHESIS%HUMANCYC%PWY-6352	3-phosphoinositide biosynthesis	0.004453930777695916	0.004453930777695916	+1	PIK3CA,PIK3R1,PIK3CG
VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 73%5218920	VEGFR2 mediated vascular permeability	0.004453930777695916	0.004453930777695916	+1	CTNNB1,AKT1,MTOR
REGULATION OF RESPONSE TO REACTIVE OXYGEN SPECIES%GOBP%GO:1901031	regulation of response to reactive oxygen species	0.004453930777695916	0.004453930777695916	+1	NFE2L2,HGF,LRRK2
PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY	PID_ALK1_PATHWAY	0.004453930777695916	0.004453930777695916	+1	SMAD4,TGFBR2,ACVR2A
POSITIVE REGULATION OF GLUCOSE IMPORT%GOBP%GO:0046326	positive regulation of glucose import	0.004453930777695916	0.004453930777695916	+1	PIK3R1,AKT1,PTPN11
CRANIAL SKELETAL SYSTEM DEVELOPMENT%GOBP%GO:1904888	cranial skeletal system development	0.004453930777695916	0.004453930777695916	+1	PDGFRA,FGFR2,TGFBR2
ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS	ALK1 signaling events	0.004453930777695916	0.004453930777695916	+1	SMAD4,TGFBR2,ACVR2A
TOR SIGNALING%GOBP%GO:0031929	TOR signaling	0.004453930777695916	0.004453930777695916	+1	GATA3,AKT1,MTOR
POSITIVE REGULATION OF GENE SILENCING BY MIRNA%GOBP%GO:2000637	positive regulation of gene silencing by miRNA	0.004453930777695916	0.004453930777695916	+1	TP53,EGFR,AJUBA
EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20200810%WP4300%HOMO SAPIENS	Extracellular vesicles in the crosstalk of cardiac cells	0.004453930777695916	0.004453930777695916	+1	PTEN,EGFR,TLR4
RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 73%5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.004453930777695916	0.004453930777695916	+1	ATM,BRCA1,BRCA2
IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS	IL3-mediated signaling events	0.004453930777695916	0.004453930777695916	+1	PIK3CA,PIK3R1,PTPN11
EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING	Ephrin B reverse signaling	0.004453930777695916	0.004453930777695916	+1	PIK3CA,PIK3R1,MAP2K4
NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.2	Negative regulation of FGFR1 signaling	0.004453930777695916	0.004453930777695916	+1	BRAF,PPP2R1A,PTPN11
TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-HSA-8986944.2	Transcriptional Regulation by MECP2	0.0044968470272501075	0.0044968470272501075	+1	PTEN,SIN3A,TBL1XR1,NCOR1
DIGESTIVE TRACT DEVELOPMENT%GOBP%GO:0048565	digestive tract development	0.0044968470272501075	0.0044968470272501075	+1	KIT,PDGFRA,FGFR2,SOX17
REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 73%8943724	Regulation of PTEN gene transcription	0.0044968470272501075	0.0044968470272501075	+1	TP53,MTOR,MECOM,EZH2
SPINDLE ASSEMBLY%GOBP%GO:0051225	spindle assembly	0.004570889076651995	0.004570889076651995	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
CELLULAR RESPONSE TO OXYGEN LEVELS%GOBP%GO:0071453	cellular response to oxygen levels	0.004659447789989886	0.004659447789989886	+1	TP53,VHL,NOTCH1,NFE2L2,MTOR,EP300
CIRCADIAN RHYTHM RELATED GENES%WIKIPATHWAYS_20200810%WP3594%HOMO SAPIENS	Circadian rhythm related genes	0.004686612759880816	0.004686612759880816	+1	TP53,PTEN,EP300,SIN3A,EGR3,NCOR1,EZH2
REGULATION OF PROTEIN LOCALIZATION TO CELL PERIPHERY%GOBP%GO:1904375	regulation of protein localization to cell periphery	0.004757269550414794	0.004757269550414794	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
KIDNEY EPITHELIUM DEVELOPMENT%GOBP%GO:0072073	kidney epithelium development	0.004757269550414794	0.004757269550414794	+1	GATA3,SOX9,WT1,FGFR2
TUBE FORMATION%GOBP%GO:0035148	tube formation	0.004757269550414794	0.004757269550414794	+1	GATA3,NOTCH1,SOX9,FGFR2
PROTEIN ALKYLATION%GOBP%GO:0008213	protein alkylation	0.004757269550414794	0.004757269550414794	+1	KDM6A,TET2,SETD2,NSD1,EZH2
PROTEIN METHYLATION%GOBP%GO:0006479	protein methylation	0.004757269550414794	0.004757269550414794	+1	KDM6A,TET2,SETD2,NSD1,EZH2
POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN%GOBP%GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	0.004757269550414794	0.004757269550414794	+1	FLT3,ERBB4,KIT,FGFR3
REGULATION OF GENE SILENCING%GOBP%GO:0060968	regulation of gene silencing	0.0047880877540916085	0.0047880877540916085	+1	TP53,EGFR,AJUBA,HIST1H1C,SIN3A,NCOR1
BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY	BIOCARTA_CREB_PATHWAY	0.004882213316499733	0.004882213316499733	+1	PIK3CA,PIK3R1,AKT1
POSITIVE REGULATION OF POSTTRANSCRIPTIONAL GENE SILENCING%GOBP%GO:0060148	positive regulation of posttranscriptional gene silencing	0.004882213316499733	0.004882213316499733	+1	TP53,EGFR,AJUBA
SIG_IL4RECEPTOR_IN_B_LYPHOCYTES%MSIGDB_C2%SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	0.004882213316499733	0.004882213316499733	+1	PIK3CA,PIK3R1,AKT1
NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 73%5654733	Negative regulation of FGFR4 signaling	0.004882213316499733	0.004882213316499733	+1	BRAF,PPP2R1A,PTPN11
POSITIVE REGULATION OF G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	0.004882213316499733	0.004882213316499733	+1	EGFR,AKT1,CCND1
CELLULAR RESPONSE TO EPIDERMAL GROWTH FACTOR STIMULUS%GOBP%GO:0071364	cellular response to epidermal growth factor stimulus	0.004882213316499733	0.004882213316499733	+1	EGFR,SOX9,PTPN11
PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY	PID_IL3_PATHWAY	0.004882213316499733	0.004882213316499733	+1	PIK3CA,PIK3R1,PTPN11
FGFR3 SIGNALLING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20200810%WP4767%HOMO SAPIENS	FGFR3 signalling in chondrocyte proliferation and terminal differentiation	0.004882213316499733	0.004882213316499733	+1	SOX9,FGFR3,CDKN1A
NEGATIVE REGULATION OF SISTER CHROMATID SEGREGATION%GOBP%GO:0033046	negative regulation of sister chromatid segregation	0.004882213316499733	0.004882213316499733	+1	APC,ATM,ATRX
ST_GRANULE_CELL_SURVIVAL_PATHWAY%MSIGDB_C2%ST_GRANULE_CELL_SURVIVAL_PATHWAY	ST_GRANULE_CELL_SURVIVAL_PATHWAY	0.004882213316499733	0.004882213316499733	+1	APC,MAP2K4,MAPK8IP1
EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0001837	epithelial to mesenchymal transition	0.005005035032584578	0.005005035032584578	+1	NOTCH1,CTNNB1,SOX9,HGF
DIGESTIVE SYSTEM DEVELOPMENT%GOBP%GO:0055123	digestive system development	0.005005035032584578	0.005005035032584578	+1	KIT,PDGFRA,FGFR2,SOX17
NEGATIVE REGULATION OF WOUND HEALING%GOBP%GO:0061045	negative regulation of wound healing	0.005005035032584578	0.005005035032584578	+1	PTEN,CDKN1B,PDGFRA,CDKN1A
GENES INVOLVED IN MALE INFERTILITY%WIKIPATHWAYS_20200810%WP4673%HOMO SAPIENS	Genes involved in male infertility	0.005061602318106068	0.005061602318106068	+1	NFE2L2,AR,ATM,EP300,BRCA2,ERCC2
CARDIAC CELL FATE COMMITMENT%GOBP%GO:0060911	cardiac cell fate commitment	0.005086752053675944	0.005086752053675944	+1	WT1,SOX17
NEPHRON TUBULE FORMATION%GOBP%GO:0072079	nephron tubule formation	0.005086752053675944	0.005086752053675944	+1	GATA3,SOX9
SMAD PROTEIN COMPLEX ASSEMBLY%GOBP%GO:0007183	SMAD protein complex assembly	0.005086752053675944	0.005086752053675944	+1	SMAD4,SMAD2
MULTICELLULAR ORGANISM AGING%GOBP%GO:0010259	multicellular organism aging	0.005086752053675944	0.005086752053675944	+1	TP53,LRRK2
POSITIVE REGULATION OF GONAD DEVELOPMENT%GOBP%GO:1905941	positive regulation of gonad development	0.005086752053675944	0.005086752053675944	+1	SOX9,WT1
EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.1	EGFR Transactivation by Gastrin	0.005086752053675944	0.005086752053675944	+1	EGFR,NRAS
REGULATION OF MALE GONAD DEVELOPMENT%GOBP%GO:2000018	regulation of male gonad development	0.005086752053675944	0.005086752053675944	+1	SOX9,WT1
NEGATIVE REGULATION OF OLIGODENDROCYTE DIFFERENTIATION%GOBP%GO:0048715	negative regulation of oligodendrocyte differentiation	0.005086752053675944	0.005086752053675944	+1	NF1,NOTCH1
CELLULAR RESPONSE TO GONADOTROPIN STIMULUS%GOBP%GO:0071371	cellular response to gonadotropin stimulus	0.005086752053675944	0.005086752053675944	+1	NOTCH1,WT1
ATRIOVENTRICULAR VALVE FORMATION%GOBP%GO:0003190	atrioventricular valve formation	0.005086752053675944	0.005086752053675944	+1	NOTCH1,SMAD4
POSITIVE REGULATION OF CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	0.005086752053675944	0.005086752053675944	+1	NOTCH1,TGFBR2
LOCOMOTOR RHYTHM%GOBP%GO:0045475	locomotor rhythm	0.005086752053675944	0.005086752053675944	+1	PTEN,NCOR1
RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.1	RUNX2 regulates genes involved in cell migration	0.005086752053675944	0.005086752053675944	+1	AKT1,CBFB
RESPONSE TO RETINOIC ACID%GOBP%GO:0032526	response to retinoic acid	0.005251270892760762	0.005251270892760762	+1	EPHA3,SOX9,ATM,ASXL1
POSITIVE REGULATION OF GENE EXPRESSION, EPIGENETIC%GOBP%GO:0045815	positive regulation of gene expression, epigenetic	0.005251270892760762	0.005251270892760762	+1	ARID1A,HIST1H1C,EP300,SF3B1
NEGATIVE REGULATION OF HEMOPOIESIS%GOBP%GO:1903707	negative regulation of hemopoiesis	0.0052567547726379135	0.0052567547726379135	+1	NOTCH1,FBXW7,RUNX1,TLR4,CBFB
RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 73%2500257	Resolution of Sister Chromatid Cohesion	0.0052567547726379135	0.0052567547726379135	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO STRESS%GOBP%GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	0.0052567547726379135	0.0052567547726379135	+1	TP53,VHL,NOTCH1,NFE2L2,EP300
BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY	BIOCARTA_GH_PATHWAY	0.005293686856833827	0.005293686856833827	+1	PIK3CA,PIK3R1,PIK3CG
REGULATION OF ANDROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0060765	regulation of androgen receptor signaling pathway	0.005293686856833827	0.005293686856833827	+1	EP300,TAF1,NCOR1
NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.3	Notch-HLH transcription pathway	0.005293686856833827	0.005293686856833827	+1	NOTCH1,TBL1XR1,NCOR1
POSITIVE REGULATION OF KIDNEY DEVELOPMENT%GOBP%GO:0090184	positive regulation of kidney development	0.005293686856833827	0.005293686856833827	+1	GATA3,SOX9,WT1
NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME%R-HSA-5654727.1	Negative regulation of FGFR2 signaling	0.005293686856833827	0.005293686856833827	+1	BRAF,PPP2R1A,PTPN11
CELLULAR RESPONSE TO INTERLEUKIN-6%GOBP%GO:0071354	cellular response to interleukin-6	0.005293686856833827	0.005293686856833827	+1	CEBPA,SMAD4,PTPN11
AUTONOMIC NERVOUS SYSTEM DEVELOPMENT%GOBP%GO:0048483	autonomic nervous system development	0.005293686856833827	0.005293686856833827	+1	NF1,GATA3,CTNNB1
NEGATIVE REGULATION OF CHROMOSOME SEGREGATION%GOBP%GO:0051985	negative regulation of chromosome segregation	0.005293686856833827	0.005293686856833827	+1	APC,ATM,ATRX
REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY	Reelin signaling pathway	0.005293686856833827	0.005293686856833827	+1	PIK3CA,PIK3R1,AKT1
POSITIVE REGULATION OF T CELL DIFFERENTIATION%GOBP%GO:0045582	positive regulation of T cell differentiation	0.005509130940755369	0.005509130940755369	+1	GATA3,RUNX1,TGFBR2,CBFB
PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY	PID_IL4_2PATHWAY	0.005509130940755369	0.005509130940755369	+1	PIK3CA,PIK3R1,AKT1,MTOR
IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS	IL4-mediated signaling events	0.005509130940755369	0.005509130940755369	+1	PIK3CA,PIK3R1,AKT1,MTOR
BEHAVIOR%GOBP%GO:0007610	behavior	0.005583023649450518	0.005583023649450518	+1	TP53,PTEN,EGFR,NF1,LRRK2,FOXA2,NCOR1
TRANSMEMBRANE RECEPTOR PROTEIN SERINE/THREONINE KINASE SIGNALING PATHWAY%GOBP%GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.005621975314462533	0.005621975314462533	+1	SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
REGULATION OF MUSCLE CELL DIFFERENTIATION%GOBP%GO:0051147	regulation of muscle cell differentiation	0.005649842542310889	0.005649842542310889	+1	NOTCH1,CTNNB1,KIT,FGFR2,SMAD4
TNFALPHA%IOB%TNFALPHA	TNFalpha	0.005720131284092792	0.005720131284092792	+1	TP53,EGFR,RB1,FBXW7,MAP3K1,AKT1,PTPN11
BETA-CATENIN-TCF COMPLEX ASSEMBLY%GOBP%GO:1904837	beta-catenin-TCF complex assembly	0.005797303903174806	0.005797303903174806	+1	CTNNB1,EP300,AXIN2
POSITIVE REGULATION OF MITOTIC CELL CYCLE PHASE TRANSITION%GOBP%GO:1901992	positive regulation of mitotic cell cycle phase transition	0.005797303903174806	0.005797303903174806	+1	EGFR,RB1,AKT1,CCND1
NANOPARTICLE-MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20200810%WP2643%HOMO SAPIENS	Nanoparticle-mediated activation of receptor signaling	0.005797303903174806	0.005797303903174806	+1	KRAS,EGFR,NRAS
ENDOCARDIAL CUSHION MORPHOGENESIS%GOBP%GO:0003203	endocardial cushion morphogenesis	0.005797303903174806	0.005797303903174806	+1	NOTCH1,SOX9,TGFBR2
REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 73%9022692	Regulation of MECP2 expression and activity	0.005797303903174806	0.005797303903174806	+1	SIN3A,TBL1XR1,NCOR1
EAR DEVELOPMENT%GOBP%GO:0043583	ear development	0.005797303903174806	0.005797303903174806	+1	GATA3,SOX9,FGFR2,PTPN11
BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY	BIOCARTA_TNFR1_PATHWAY	0.005797303903174806	0.005797303903174806	+1	RB1,MAP3K1,MAP2K4
NEPHRON TUBULE MORPHOGENESIS%GOBP%GO:0072078	nephron tubule morphogenesis	0.005797303903174806	0.005797303903174806	+1	GATA3,SOX9,WT1
POSITIVE REGULATION OF PROTEIN LOCALIZATION TO MEMBRANE%GOBP%GO:1905477	positive regulation of protein localization to membrane	0.005841234065576284	0.005841234065576284	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1
METHYLATION%GOBP%GO:0032259	methylation	0.005976640828290886	0.005976640828290886	+1	DNMT3A,KDM6A,TET2,ATRX,SETD2,NSD1,EZH2
REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS%GOBP%GO:0090287	regulation of cellular response to growth factor stimulus	0.005976640828290886	0.005976640828290886	+1	GATA3,NOTCH1,STK11,EP300,SMAD4,TGFBR2,SMAD2
PEPTIDYL-LYSINE METHYLATION%GOBP%GO:0018022	peptidyl-lysine methylation	0.006117836635993901	0.006117836635993901	+1	KDM6A,TET2,SETD2,EZH2
REGULATION OF PROTEIN LOCALIZATION TO MEMBRANE%GOBP%GO:1905475	regulation of protein localization to membrane	0.006312739070755539	0.006312739070755539	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1,AR
MICROTUBULE CYTOSKELETON ORGANIZATION INVOLVED IN MITOSIS%GOBP%GO:1902850	microtubule cytoskeleton organization involved in mitosis	0.006314996646365334	0.006314996646365334	+1	STAG2,CHEK2,SETD2,SMC1A,SMC3
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 73%6804758	Regulation of TP53 Activity through Acetylation	0.006315022535485662	0.006315022535485662	+1	TP53,AKT1,EP300
NEGATIVE REGULATION OF NOTCH SIGNALING PATHWAY%GOBP%GO:0045746	negative regulation of Notch signaling pathway	0.006315022535485662	0.006315022535485662	+1	EGFR,FBXW7,AKT1
IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5	IL2 signaling events mediated by STAT5	0.006315022535485662	0.006315022535485662	+1	PIK3CA,PIK3R1,PTPN11
BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY	BIOCARTA_FAS_PATHWAY	0.006315022535485662	0.006315022535485662	+1	RB1,MAP3K1,MAP2K4
AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009	Axon guidance mediated by netrin	0.006315022535485662	0.006315022535485662	+1	PIK3CA,PIK3R1,PIK3CG
PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY	PID_EPHRINB_REV_PATHWAY	0.006315022535485662	0.006315022535485662	+1	PIK3CA,PIK3R1,MAP2K4
POSITIVE REGULATION OF HISTONE METHYLATION%GOBP%GO:0031062	positive regulation of histone methylation	0.006315022535485662	0.006315022535485662	+1	CTNNB1,BRCA1,SMAD4
RESPONSE TO EPIDERMAL GROWTH FACTOR%GOBP%GO:0070849	response to epidermal growth factor	0.006315022535485662	0.006315022535485662	+1	EGFR,SOX9,PTPN11
PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY	PID_IL2_STAT5_PATHWAY	0.006315022535485662	0.006315022535485662	+1	PIK3CA,PIK3R1,PTPN11
FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.1	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.006315022535485662	0.006315022535485662	+1	SMAD4,SIN3A,SMAD2
PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY	PID_RAS_PATHWAY	0.006315022535485662	0.006315022535485662	+1	KRAS,NF1,NRAS
STRESS-INDUCED PREMATURE SENESCENCE%GOBP%GO:0090400	stress-induced premature senescence	0.006373886715540296	0.006373886715540296	+1	TP53,CDKN1A
ENTRY OF BACTERIUM INTO HOST CELL%GOBP%GO:0035635	entry of bacterium into host cell	0.006373886715540296	0.006373886715540296	+1	CTNNB1,CDH1
IMMATURE B CELL DIFFERENTIATION%GOBP%GO:0002327	immature B cell differentiation	0.006373886715540296	0.006373886715540296	+1	ATM,KIT
REGULATION OF PROTEIN LOCALIZATION TO CHROMATIN%GOBP%GO:1905634	regulation of protein localization to chromatin	0.006373886715540296	0.006373886715540296	+1	RB1,SETD2
DNA DAMAGE INDUCED PROTEIN PHOSPHORYLATION%GOBP%GO:0006975	DNA damage induced protein phosphorylation	0.006373886715540296	0.006373886715540296	+1	ATM,CHEK2
ENDOCHONDRAL BONE GROWTH%GOBP%GO:0003416	endochondral bone growth	0.006373886715540296	0.006373886715540296	+1	SOX9,FGFR3
REGULATION OF MAMMARY GLAND EPITHELIAL CELL PROLIFERATION%GOBP%GO:0033599	regulation of mammary gland epithelial cell proliferation	0.006373886715540296	0.006373886715540296	+1	GATA3,BRCA2
AXIS ELONGATION%GOBP%GO:0003401	axis elongation	0.006373886715540296	0.006373886715540296	+1	SOX9,FGFR2
MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.1	MET activates RAS signaling	0.006373886715540296	0.006373886715540296	+1	NRAS,HGF
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.1	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	0.006373886715540296	0.006373886715540296	+1	RUNX1,CBFB
CELLULAR RESPONSE TO UV-B%GOBP%GO:0071493	cellular response to UV-B	0.006373886715540296	0.006373886715540296	+1	STK11,CDKN1A
MAMMARY GLAND EPITHELIAL CELL DIFFERENTIATION%GOBP%GO:0060644	mammary gland epithelial cell differentiation	0.006373886715540296	0.006373886715540296	+1	AKT1,ERBB4
NEGATIVE REGULATION OF LEUKOCYTE DIFFERENTIATION%GOBP%GO:1902106	negative regulation of leukocyte differentiation	0.006373886715540296	0.006373886715540296	+1	FBXW7,RUNX1,TLR4,CBFB
BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.3	Binding of TCF LEF:CTNNB1 to target gene promoters	0.006373886715540296	0.006373886715540296	+1	CTNNB1,AXIN2
LDLRAD4 AND WHAT WE KNOW ABOUT IT%WIKIPATHWAYS_20200810%WP4904%HOMO SAPIENS	LDLRAD4 and what we know about it	0.006373886715540296	0.006373886715540296	+1	TGFBR2,SMAD2
DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20200810%WP3300%HOMO SAPIENS	Dual hijack model of Vif in HIV infection	0.006373886715540296	0.006373886715540296	+1	RUNX1,CBFB
RESPONSE TO GONADOTROPIN%GOBP%GO:0034698	response to gonadotropin	0.006373886715540296	0.006373886715540296	+1	NOTCH1,WT1
REGULATION OF ENDODEOXYRIBONUCLEASE ACTIVITY%GOBP%GO:0032071	regulation of endodeoxyribonuclease activity	0.006373886715540296	0.006373886715540296	+1	NPM1,AKT1
RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 73%8951430	RUNX3 regulates WNT signaling	0.006373886715540296	0.006373886715540296	+1	CTNNB1,CCND1
HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK	HIF-1-alpha transcription factor network	0.006373886715540296	0.006373886715540296	+1	NPM1,AKT1,EP300,SMAD4
POSITIVE REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	0.006373886715540296	0.006373886715540296	+1	RUNX1,CBFB
PHOSPHATIDYLINOSITOL-3-PHOSPHATE BIOSYNTHETIC PROCESS%GOBP%GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	0.006373886715540296	0.006373886715540296	+1	PIK3CA,PIK3CG
REGULATION OF DNA-TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS%GOBP%GO:0043620	regulation of DNA-templated transcription in response to stress	0.0063829595489841495	0.0063829595489841495	+1	TP53,VHL,NOTCH1,NFE2L2,EP300
REGULATION OF PROTEASOMAL UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0063829595489841495	0.0063829595489841495	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
NEGATIVE REGULATION OF SUPRAMOLECULAR FIBER ORGANIZATION%GOBP%GO:1902904	negative regulation of supramolecular fiber organization	0.0063829595489841495	0.0063829595489841495	+1	PIK3CA,APC,NAV3,PIK3R1,SMAD4
REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS%GOBP%GO:0061136	regulation of proteasomal protein catabolic process	0.006509148798552722	0.006509148798552722	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
REGULATION OF MICROTUBULE CYTOSKELETON ORGANIZATION%GOBP%GO:0070507	regulation of microtubule cytoskeleton organization	0.006509148798552722	0.006509148798552722	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,BRCA1
REGULATION OF MITOTIC SISTER CHROMATID SEGREGATION%GOBP%GO:0033047	regulation of mitotic sister chromatid segregation	0.006624544564489421	0.006624544564489421	+1	APC,RB1,ATM,ATRX
PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY	PID_HIF1_TFPATHWAY	0.006624544564489421	0.006624544564489421	+1	NPM1,AKT1,EP300,SMAD4
NEGATIVE REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	0.006734446067049224	0.006734446067049224	+1	CRIPAK,BRCA1,NCOR1
NEGATIVE REGULATION OF CELL ADHESION%GOBP%GO:0007162	negative regulation of cell adhesion	0.006734446067049224	0.006734446067049224	+1	PTEN,CDKN2A,NOTCH1,CDH1,RUNX1,AKT1,CBFB
OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS	Osteopontin-mediated events	0.006734446067049224	0.006734446067049224	+1	PIK3CA,PIK3R1,MAP3K1
PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY	PID_AVB3_OPN_PATHWAY	0.006734446067049224	0.006734446067049224	+1	PIK3CA,PIK3R1,MAP3K1
NEGATIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:0048662	negative regulation of smooth muscle cell proliferation	0.006734446067049224	0.006734446067049224	+1	PTEN,CDKN1B,CDKN1A
URETERIC BUD DEVELOPMENT%GOBP%GO:0001657	ureteric bud development	0.006734446067049224	0.006734446067049224	+1	GATA3,WT1,FGFR2
G2 DNA DAMAGE CHECKPOINT%GOBP%GO:0031572	G2 DNA damage checkpoint	0.006734446067049224	0.006734446067049224	+1	ATM,BRCA1,CDKN1A
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.3	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.006734446067049224	0.006734446067049224	+1	APC,CTNNB1,PPP2R1A
PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY	PID_CD40_PATHWAY	0.006734446067049224	0.006734446067049224	+1	MAP3K1,MAP2K4,AKT1
TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 73%2173789	TGF-beta receptor signaling activates SMADs	0.006734446067049224	0.006734446067049224	+1	SMAD4,TGFBR2,SMAD2
SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 73%2559582	Senescence-Associated Secretory Phenotype (SASP)	0.006828419798007854	0.006828419798007854	+1	CDKN2A,CDKN1B,CDKN1A,HIST1H2BD,CDKN2C
INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034	Integrin signalling pathway	0.00684695464413201	0.00684695464413201	+1	PIK3CA,PIK3R1,NRAS,MAP2K4,BRAF,PIK3CG
EPITHELIAL CELL MIGRATION%GOBP%GO:0010631	epithelial cell migration	0.006919528112047354	0.006919528112047354	+1	PIK3CA,AKT1,KIT,EGR3
SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%HUMANCYC%PWY-6371	superpathway of inositol phosphate compounds	0.006919528112047354	0.006919528112047354	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 73%5685942	HDR through Homologous Recombination (HRR)	0.006919528112047354	0.006919528112047354	+1	ATM,BRCA1,BRCA2,ATR
CELLULAR RESPONSE TO NUTRIENT LEVELS%GOBP%GO:0031669	cellular response to nutrient levels	0.007254295080276122	0.007254295080276122	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING	p75(NTR)-mediated signaling	0.007284146902431161	0.007284146902431161	+1	TP53,PIK3CA,PIK3R1,AKT1
SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 73%5655302	Signaling by FGFR1 in disease	0.007284146902431161	0.007284146902431161	+1	PIK3CA,PIK3R1,NRAS
MESONEPHRIC EPITHELIUM DEVELOPMENT%GOBP%GO:0072163	mesonephric epithelium development	0.007284146902431161	0.007284146902431161	+1	GATA3,WT1,FGFR2
GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20200810%WP2363%HOMO SAPIENS	Gastric Cancer Network 2	0.007284146902431161	0.007284146902431161	+1	TP53,EGFR,CTNNB1
ANTERIOR/POSTERIOR AXIS SPECIFICATION%GOBP%GO:0009948	anterior/posterior axis specification	0.007284146902431161	0.007284146902431161	+1	TBX3,WT1,FOXA2
NEPHRON MORPHOGENESIS%GOBP%GO:0072028	nephron morphogenesis	0.007284146902431161	0.007284146902431161	+1	GATA3,SOX9,WT1
NEGATIVE REGULATION OF CELLULAR CARBOHYDRATE METABOLIC PROCESS%GOBP%GO:0010677	negative regulation of cellular carbohydrate metabolic process	0.007284146902431161	0.007284146902431161	+1	EP300,FOXA2,NCOR1
OVARIAN INFERTILITY GENES%WIKIPATHWAYS_20200810%WP34%HOMO SAPIENS	Ovarian Infertility Genes	0.007284146902431161	0.007284146902431161	+1	ATM,CDKN1B,NCOR1
RAF ACTIVATION%REACTOME%R-HSA-5673000.2	RAF activation	0.007284146902431161	0.007284146902431161	+1	NRAS,BRAF,PPP2R1A
MESONEPHRIC TUBULE DEVELOPMENT%GOBP%GO:0072164	mesonephric tubule development	0.007284146902431161	0.007284146902431161	+1	GATA3,WT1,FGFR2
NEPHRON EPITHELIUM MORPHOGENESIS%GOBP%GO:0072088	nephron epithelium morphogenesis	0.007284146902431161	0.007284146902431161	+1	GATA3,SOX9,WT1
RENAL TUBULE MORPHOGENESIS%GOBP%GO:0061333	renal tubule morphogenesis	0.007284146902431161	0.007284146902431161	+1	GATA3,SOX9,WT1
G2 M CHECKPOINTS%REACTOME%R-HSA-69481.3	G2 M Checkpoints	0.007399444033875935	0.007399444033875935	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
HCMV EARLY EVENTS%REACTOME DATABASE ID RELEASE 73%9609690	HCMV Early Events	0.007543349149253122	0.007543349149253122	+1	EGFR,HIST1H2BD,TBL1XR1,NCOR1,EZH2
REGULATION OF TYPE I INTERFERON PRODUCTION%GOBP%GO:0032479	regulation of type I interferon production	0.007543349149253122	0.007543349149253122	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
AMEBOIDAL-TYPE CELL MIGRATION%GOBP%GO:0001667	ameboidal-type cell migration	0.007543349149253122	0.007543349149253122	+1	PIK3CA,AKT1,ERBB4,KIT,EGR3
EPITHELIUM MIGRATION%GOBP%GO:0090132	epithelium migration	0.007579300974982917	0.007579300974982917	+1	PIK3CA,AKT1,KIT,EGR3
PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY	PID_P75_NTR_PATHWAY	0.007579300974982917	0.007579300974982917	+1	TP53,PIK3CA,PIK3R1,AKT1
REGULATION OF STRIATED MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0016202	regulation of striated muscle tissue development	0.007579300974982917	0.007579300974982917	+1	NOTCH1,ERBB4,FGFR2,SMAD4
REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION%GOBP%GO:1903747	regulation of establishment of protein localization to mitochondrion	0.007579300974982917	0.007579300974982917	+1	TP53,FBXW7,BAP1,LRRK2
DNA REPLICATION%GOBP%GO:0006260	DNA replication	0.007579300974982917	0.007579300974982917	+1	ATM,ATRX,BRCA1,POLQ,BRCA2,ATR
NEGATIVE REGULATION OF CELL MOTILITY%GOBP%GO:2000146	negative regulation of cell motility	0.007602764066705736	0.007602764066705736	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1
NEGATIVE REGULATION OF JNK CASCADE%GOBP%GO:0046329	negative regulation of JNK cascade	0.007746689112253675	0.007746689112253675	+1	MAPK8IP1,MECOM,NCOR1
EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS	EGFR-dependent Endothelin signaling events	0.007746689112253675	0.007746689112253675	+1	EGFR,MTOR
RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20200810%WP4481%HOMO SAPIENS	Resistin as a regulator of inflammation	0.007746689112253675	0.007746689112253675	+1	PIK3CA,AKT1,PIK3CG
INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.1	InlA-mediated entry of Listeria monocytogenes into host cells	0.007746689112253675	0.007746689112253675	+1	CTNNB1,CDH1
EMBRYONIC DIGESTIVE TRACT MORPHOGENESIS%GOBP%GO:0048557	embryonic digestive tract morphogenesis	0.007746689112253675	0.007746689112253675	+1	PDGFRA,FGFR2
PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.3	PI3K AKT activation	0.007746689112253675	0.007746689112253675	+1	PIK3CA,PIK3R1
RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.1	Resolution of D-loop Structures through Holliday Junction Intermediates	0.007746689112253675	0.007746689112253675	+1	ATM,BRCA1,BRCA2
NEGATIVE REGULATION OF ORGANELLE ASSEMBLY%GOBP%GO:1902116	negative regulation of organelle assembly	0.007746689112253675	0.007746689112253675	+1	BRCA1,LRRK2,SMAD4
CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS%GOBP%GO:0071560	cellular response to transforming growth factor beta stimulus	0.007746689112253675	0.007746689112253675	+1	SOX9,SMAD4,USP9X,TGFBR2,SMAD2
BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY	BIOCARTA_AT1R_PATHWAY	0.007746689112253675	0.007746689112253675	+1	EGFR,MAP3K1,MAP2K4
REGULATION OF NEPHRON TUBULE EPITHELIAL CELL DIFFERENTIATION%GOBP%GO:0072182	regulation of nephron tubule epithelial cell differentiation	0.007746689112253675	0.007746689112253675	+1	GATA3,CTNNB1
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-HSA-9028731.1	Activated NTRK2 signals through FRS2 and FRS3	0.007746689112253675	0.007746689112253675	+1	NRAS,PTPN11
NODAL SIGNALING PATHWAY%GOBP%GO:0038092	nodal signaling pathway	0.007746689112253675	0.007746689112253675	+1	ACVR1B,SMAD2
NEGATIVE REGULATION OF FATTY ACID OXIDATION%GOBP%GO:0046322	negative regulation of fatty acid oxidation	0.007746689112253675	0.007746689112253675	+1	AKT1,SOX9
REGULATION OF MYOBLAST DIFFERENTIATION%GOBP%GO:0045661	regulation of myoblast differentiation	0.007746689112253675	0.007746689112253675	+1	NOTCH1,TBX3,SOX9
CELLULAR RESPONSE TO OXIDISED LOW-DENSITY LIPOPROTEIN PARTICLE STIMULUS%GOBP%GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	0.007746689112253675	0.007746689112253675	+1	AKT1,TLR4
PI5P REGULATES TP53 ACETYLATION%REACTOME%R-HSA-6811555.2	PI5P Regulates TP53 Acetylation	0.007746689112253675	0.007746689112253675	+1	TP53,EP300
POSITIVE REGULATION OF CELL-CELL ADHESION MEDIATED BY CADHERIN%GOBP%GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	0.007746689112253675	0.007746689112253675	+1	FOXA1,FOXA2
MAST CELL DEGRANULATION%GOBP%GO:0043303	mast cell degranulation	0.007746689112253675	0.007746689112253675	+1	PIK3CG,KIT
WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20200810%WP4149%HOMO SAPIENS	White fat cell differentiation	0.007746689112253675	0.007746689112253675	+1	GATA3,CEBPA,MECOM
PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.4	PI3K events in ERBB4 signaling	0.007746689112253675	0.007746689112253675	+1	PIK3CA,PIK3R1
POSITIVE REGULATION OF ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0046638	positive regulation of alpha-beta T cell differentiation	0.007746689112253675	0.007746689112253675	+1	RUNX1,TGFBR2,CBFB
REGULATION OF PEPTIDYL-SERINE PHOSPHORYLATION%GOBP%GO:0033135	regulation of peptidyl-serine phosphorylation	0.007746689112253675	0.007746689112253675	+1	PTEN,EGFR,AKT1,BRAF,NSD1
REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION	Regulation of Ras family activation	0.007746689112253675	0.007746689112253675	+1	KRAS,NF1,NRAS
MAST CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE%GOBP%GO:0002279	mast cell activation involved in immune response	0.007746689112253675	0.007746689112253675	+1	PIK3CG,KIT
MONOUBIQUITINATED PROTEIN DEUBIQUITINATION%GOBP%GO:0035520	monoubiquitinated protein deubiquitination	0.007746689112253675	0.007746689112253675	+1	BAP1,ASXL1
REGULATION OF MUSCLE TISSUE DEVELOPMENT%GOBP%GO:1901861	regulation of muscle tissue development	0.007800979106584303	0.007800979106584303	+1	NOTCH1,ERBB4,FGFR2,SMAD4
NEGATIVE REGULATION OF RESPONSE TO WOUNDING%GOBP%GO:1903035	negative regulation of response to wounding	0.007800979106584303	0.007800979106584303	+1	PTEN,CDKN1B,PDGFRA,CDKN1A
HISTONE MODIFICATIONS%WIKIPATHWAYS_20200810%WP2369%HOMO SAPIENS	Histone Modifications	0.007800979106584303	0.007800979106584303	+1	SETBP1,SETD2,NSD1,EZH2
ENDOTHELIUM DEVELOPMENT%GOBP%GO:0003158	endothelium development	0.007800979106584303	0.007800979106584303	+1	NOTCH1,CTNNB1,SMAD4,SOX17
PLATELET ACTIVATION%GOBP%GO:0030168	platelet activation	0.007904346035228145	0.007904346035228145	+1	PIK3CA,PIK3R1,PIK3CG,PDGFRA,PTPN11
NEGATIVE REGULATION OF CELL DEVELOPMENT%GOBP%GO:0010721	negative regulation of cell development	0.008068258415387752	0.008068258415387752	+1	PTEN,NF1,NOTCH1,FBXW7,SOX9,SMAD4
POSITIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION%GOBP%GO:0045621	positive regulation of lymphocyte differentiation	0.008186660678126505	0.008186660678126505	+1	GATA3,RUNX1,TGFBR2,CBFB
PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.3	PKMTs methylate histone lysines	0.008186660678126505	0.008186660678126505	+1	SETD2,NSD1,MECOM,EZH2
CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 73%1500931	Cell-Cell communication	0.008186660678126505	0.008186660678126505	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,PTPN11
HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION%GOBP%GO:0002244	hematopoietic progenitor cell differentiation	0.008314351778191847	0.008314351778191847	+1	TP53,FLT3,KIT
FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.2	FCERI mediated MAPK activation	0.008314351778191847	0.008314351778191847	+1	MAP3K1,NRAS,MAP2K4
RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-HSA-5693537.1	Resolution of D-Loop Structures	0.008314351778191847	0.008314351778191847	+1	ATM,BRCA1,BRCA2
IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS	IL8- and CXCR2-mediated signaling events	0.008314351778191847	0.008314351778191847	+1	AKT1,PIK3CG,PPP2R1A
PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY	PID_IL8_CXCR2_PATHWAY	0.008314351778191847	0.008314351778191847	+1	AKT1,PIK3CG,PPP2R1A
SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 73%4791275	Signaling by WNT in cancer	0.008314351778191847	0.008314351778191847	+1	APC,CTNNB1,PPP2R1A
ENDOCARDIAL CUSHION DEVELOPMENT%GOBP%GO:0003197	endocardial cushion development	0.008314351778191847	0.008314351778191847	+1	NOTCH1,SOX9,TGFBR2
NEGATIVE REGULATION OF MITOTIC NUCLEAR DIVISION%GOBP%GO:0045839	negative regulation of mitotic nuclear division	0.008314351778191847	0.008314351778191847	+1	APC,ATM,ATRX
PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY	PID_MAPK_TRK_PATHWAY	0.008314351778191847	0.008314351778191847	+1	KRAS,NRAS,BRAF
TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY	Trk receptor signaling mediated by the MAPK pathway	0.008314351778191847	0.008314351778191847	+1	KRAS,NRAS,BRAF
CHONDROCYTE DIFFERENTIATION%GOBP%GO:0002062	chondrocyte differentiation	0.008314351778191847	0.008314351778191847	+1	RUNX1,SOX9,FGFR3
VENTRICULAR CARDIAC MUSCLE TISSUE MORPHOGENESIS%GOBP%GO:0055010	ventricular cardiac muscle tissue morphogenesis	0.008314351778191847	0.008314351778191847	+1	NOTCH1,FGFR2,SMAD4
SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 73%1980143	Signaling by NOTCH1	0.008532363379487038	0.008532363379487038	+1	NOTCH1,EP300,TBL1XR1,NCOR1
DETERMINATION OF LEFT/RIGHT SYMMETRY%GOBP%GO:0007368	determination of left/right symmetry	0.008946830939914323	0.008946830939914323	+1	NOTCH1,TBX3,TGFBR2,SOX17
REGULATION OF FATTY ACID METABOLIC PROCESS%GOBP%GO:0019217	regulation of fatty acid metabolic process	0.008946830939914323	0.008946830939914323	+1	AKT1,SOX9,BRCA1,NCOR1
TISSUE MIGRATION%GOBP%GO:0090130	tissue migration	0.008946830939914323	0.008946830939914323	+1	PIK3CA,AKT1,KIT,EGR3
BMP SIGNALING PATHWAY%GOBP%GO:0030509	BMP signaling pathway	0.008946830939914323	0.008946830939914323	+1	SMAD4,USP9X,ACVR2A,SMAD2
BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY	BIOCARTA_CARM_ER_PATHWAY	0.00896826049585491	0.00896826049585491	+1	BRCA1,EP300,CCND1
POSITIVE REGULATION OF PRI-MIRNA TRANSCRIPTION BY RNA POLYMERASE II%GOBP%GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	0.00896826049585491	0.00896826049585491	+1	TP53,GATA3,WT1
LIVER DEVELOPMENT%GOBP%GO:0001889	liver development	0.00896826049585491	0.00896826049585491	+1	NF1,CEBPA,ARID5B
REGULATION OF VASCULAR SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:1904705	regulation of vascular smooth muscle cell proliferation	0.00896826049585491	0.00896826049585491	+1	PTEN,CDKN1B,CDKN1A
ST_G_ALPHA_I_PATHWAY%MSIGDB_C2%ST_G_ALPHA_I_PATHWAY	ST_G_ALPHA_I_PATHWAY	0.00896826049585491	0.00896826049585491	+1	EGFR,AKT1,BRAF
NEGATIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS%GOBP%GO:0045912	negative regulation of carbohydrate metabolic process	0.00896826049585491	0.00896826049585491	+1	EP300,FOXA2,NCOR1
POSITIVE REGULATION OF OXIDATIVE STRESS-INDUCED CELL DEATH%GOBP%GO:1903209	positive regulation of oxidative stress-induced cell death	0.009221308521647773	0.009221308521647773	+1	FBXW7,TLR4
MYELIN MAINTENANCE%GOBP%GO:0043217	myelin maintenance	0.009221308521647773	0.009221308521647773	+1	PTEN,PRX
REGULATION OF CELL PROLIFERATION INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:1901722	regulation of cell proliferation involved in kidney development	0.009221308521647773	0.009221308521647773	+1	GATA3,WT1
RESPONSE TO TRANSFORMING GROWTH FACTOR BETA%GOBP%GO:0071559	response to transforming growth factor beta	0.009221308521647773	0.009221308521647773	+1	SOX9,SMAD4,USP9X,TGFBR2,SMAD2
INSULIN-LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0048009	insulin-like growth factor receptor signaling pathway	0.009221308521647773	0.009221308521647773	+1	PIK3R1,AKT1
MAST CELL MEDIATED IMMUNITY%GOBP%GO:0002448	mast cell mediated immunity	0.009221308521647773	0.009221308521647773	+1	PIK3CG,KIT
REGULATION OF GONAD DEVELOPMENT%GOBP%GO:1905939	regulation of gonad development	0.009221308521647773	0.009221308521647773	+1	SOX9,WT1
BONE GROWTH%GOBP%GO:0098868	bone growth	0.009221308521647773	0.009221308521647773	+1	SOX9,FGFR3
INSULIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0008286	insulin receptor signaling pathway	0.009221308521647773	0.009221308521647773	+1	PIK3CA,APC,PIK3R1,AKT1
MAMMARY GLAND MORPHOGENESIS%GOBP%GO:0060443	mammary gland morphogenesis	0.009221308521647773	0.009221308521647773	+1	ELF3,FGFR2
NEGATIVE REGULATION OF INTRACELLULAR ESTROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	0.009221308521647773	0.009221308521647773	+1	CRIPAK,BRCA1
NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL%GOBP%GO:1903321	negative regulation of protein modification by small protein conjugation or removal	0.009221308521647773	0.009221308521647773	+1	CTNNB1,AKT1,TAF1,RPL5
REGULATION OF DEOXYRIBONUCLEASE ACTIVITY%GOBP%GO:0032070	regulation of deoxyribonuclease activity	0.009221308521647773	0.009221308521647773	+1	NPM1,AKT1
RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 73%5626467	RHO GTPases activate IQGAPs	0.009221308521647773	0.009221308521647773	+1	CTNNB1,CDH1
PROSTATE GLAND DEVELOPMENT%GOBP%GO:0030850	prostate gland development	0.009221308521647773	0.009221308521647773	+1	SOX9,FGFR2
MAMMARY GLAND DEVELOPMENT PATHWAY - INVOLUTION (STAGE 4 OF 4)%WIKIPATHWAYS_20200810%WP2815%HOMO SAPIENS	Mammary gland development pathway - Involution (Stage 4 of 4)	0.009221308521647773	0.009221308521647773	+1	TP53,CDH1
NEGATIVE REGULATION OF COENZYME METABOLIC PROCESS%GOBP%GO:0051198	negative regulation of coenzyme metabolic process	0.009221308521647773	0.009221308521647773	+1	TP53,NCOR1
REGULATION OF CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0062042	regulation of cardiac epithelial to mesenchymal transition	0.009221308521647773	0.009221308521647773	+1	NOTCH1,TGFBR2
RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.1	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	0.009221308521647773	0.009221308521647773	+1	RUNX1,CBFB
REGULATION OF MUSCLE ORGAN DEVELOPMENT%GOBP%GO:0048634	regulation of muscle organ development	0.009221308521647773	0.009221308521647773	+1	NOTCH1,ERBB4,FGFR2,SMAD4
PROTEIN-DNA COMPLEX ASSEMBLY%GOBP%GO:0065004	protein-DNA complex assembly	0.009244777862866996	0.009244777862866996	+1	NPM1,SOX9,ATRX,TAF1,HIST1H2BD,ERCC2
TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 73%166016	Toll Like Receptor 4 (TLR4) Cascade	0.00947202949097633	0.00947202949097633	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
POSITIVE REGULATION OF INTRACELLULAR TRANSPORT%GOBP%GO:0032388	positive regulation of intracellular transport	0.009492275144480724	0.009492275144480724	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,STK11
NEPHRON TUBULE DEVELOPMENT%GOBP%GO:0072080	nephron tubule development	0.009507252264966772	0.009507252264966772	+1	GATA3,SOX9,WT1
INTRINSIC APOPTOTIC SIGNALING PATHWAY BY P53 CLASS MEDIATOR%GOBP%GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	0.009507252264966772	0.009507252264966772	+1	TP53,STK11,EP300
REGULATION OF GLUCOSE IMPORT%GOBP%GO:0046324	regulation of glucose import	0.009507252264966772	0.009507252264966772	+1	PIK3R1,AKT1,PTPN11
LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.1	LXRs regulate gene expression linked to cholesterol transport and efflux	0.009507252264966772	0.009507252264966772	+1	EP300,TBL1XR1,NCOR1
CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS%GOBP%GO:0035924	cellular response to vascular endothelial growth factor stimulus	0.009507252264966772	0.009507252264966772	+1	NOTCH1,PDGFRA,EGR3
MESONEPHROS DEVELOPMENT%GOBP%GO:0001823	mesonephros development	0.009507252264966772	0.009507252264966772	+1	GATA3,WT1,FGFR2
VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0003229	ventricular cardiac muscle tissue development	0.009507252264966772	0.009507252264966772	+1	NOTCH1,FGFR2,SMAD4
HEPATICOBILIARY SYSTEM DEVELOPMENT%GOBP%GO:0061008	hepaticobiliary system development	0.009507252264966772	0.009507252264966772	+1	NF1,CEBPA,ARID5B
NEPHRON DEVELOPMENT%GOBP%GO:0072006	nephron development	0.00959119317822416	0.00959119317822416	+1	GATA3,SOX9,WT1,PDGFRA
REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA%GOBP%GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.00959119317822416	0.00959119317822416	+1	VHL,NOTCH1,NFE2L2,EP300
SENSORY ORGAN DEVELOPMENT%GOBP%GO:0007423	sensory organ development	0.009665003947363325	0.009665003947363325	+1	NF1,GATA3,SOX9,WT1,PDGFRA,FGFR2,PTPN11
REGULATION OF NEURON DEATH%GOBP%GO:1901214	regulation of neuron death	0.009673107952231502	0.009673107952231502	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
REGULATION OF DNA REPAIR%GOBP%GO:0006282	regulation of DNA repair	0.00970253433270089	0.00970253433270089	+1	EGFR,BRCA1,POLQ,SETD2,AXIN2
REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001242	regulation of intrinsic apoptotic signaling pathway	0.00970253433270089	0.00970253433270089	+1	TP53,FBXW7,NFE2L2,AKT1,LRRK2
REGULATION OF CELLULAR RESPONSE TO HEAT%GOBP%GO:1900034	regulation of cellular response to heat	0.010020459929058635	0.010020459929058635	+1	ATM,MTOR,EP300,ATR
REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT%GOBP%GO:0046822	regulation of nucleocytoplasmic transport	0.010020459929058635	0.010020459929058635	+1	TP53,PIK3R1,CDH1,SETD2
POSITIVE REGULATION OF MUSCLE ORGAN DEVELOPMENT%GOBP%GO:0048636	positive regulation of muscle organ development	0.010117368537661155	0.010117368537661155	+1	NOTCH1,ERBB4,FGFR2
VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2	Validated transcriptional targets of AP1 family members Fra1 and Fra2	0.010117368537661155	0.010117368537661155	+1	CDKN2A,EP300,CCND1
HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5685938.1	HDR through Single Strand Annealing (SSA)	0.010117368537661155	0.010117368537661155	+1	ATM,BRCA1,ATR
PHOSPHATIDYLINOSITOL PHOSPHORYLATION%GOBP%GO:0046854	phosphatidylinositol phosphorylation	0.010117368537661155	0.010117368537661155	+1	PIK3CA,PIK3R1,PIK3CG
RESPONSE TO ESTRADIOL%GOBP%GO:0032355	response to estradiol	0.010117368537661155	0.010117368537661155	+1	EGFR,CTNNB1,FOXA1
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-HSA-111465.3	Apoptotic cleavage of cellular proteins	0.010117368537661155	0.010117368537661155	+1	APC,CTNNB1,CDH1
POSITIVE REGULATION OF STRIATED MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0045844	positive regulation of striated muscle tissue development	0.010117368537661155	0.010117368537661155	+1	NOTCH1,ERBB4,FGFR2
FEMALE SEX DIFFERENTIATION%GOBP%GO:0046660	female sex differentiation	0.010117368537661155	0.010117368537661155	+1	TBX3,KIT,PDGFRA
STEM CELL PROLIFERATION%GOBP%GO:0072089	stem cell proliferation	0.010117368537661155	0.010117368537661155	+1	RUNX1,FGFR2,MECOM
BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY	BIOCARTA_PAR1_PATHWAY	0.010117368537661155	0.010117368537661155	+1	PIK3CA,PIK3R1,PIK3CG
PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY	PID_FRA_PATHWAY	0.010117368537661155	0.010117368537661155	+1	CDKN2A,EP300,CCND1
IFN-ALPHA%IOB%IFN-ALPHA	IFN-alpha	0.010117368537661155	0.010117368537661155	+1	MAP2K4,AKT1,MTOR
BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY	BIOCARTA_TOLL_PATHWAY	0.010117368537661155	0.010117368537661155	+1	MAP3K1,MAP2K4,TLR4
ROOF OF MOUTH DEVELOPMENT%GOBP%GO:0060021	roof of mouth development	0.010117368537661155	0.010117368537661155	+1	SMAD4,TGFBR2,SMAD2
ST_GA13_PATHWAY%MSIGDB_C2%ST_GA13_PATHWAY	ST_GA13_PATHWAY	0.010117368537661155	0.010117368537661155	+1	MAP3K1,MAP2K4,AKT1
REGULATION OF ALPHA-BETA T CELL ACTIVATION%GOBP%GO:0046634	regulation of alpha-beta T cell activation	0.01037851792098126	0.01037851792098126	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
DETERMINATION OF BILATERAL SYMMETRY%GOBP%GO:0009855	determination of bilateral symmetry	0.01037851792098126	0.01037851792098126	+1	NOTCH1,TBX3,TGFBR2,SOX17
NUCLEAR CHROMOSOME SEGREGATION%GOBP%GO:0098813	nuclear chromosome segregation	0.010615383284821853	0.010615383284821853	+1	RB1,FBXW7,STAG2,SMC1A,SMC3,RAD21
MAST CELL ACTIVATION%GOBP%GO:0045576	mast cell activation	0.01067738411173486	0.01067738411173486	+1	PIK3CG,KIT
POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT%GOBP%GO:1901863	positive regulation of muscle tissue development	0.01067738411173486	0.01067738411173486	+1	NOTCH1,ERBB4,FGFR2
GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 73%179812	GRB2 events in EGFR signaling	0.01067738411173486	0.01067738411173486	+1	EGFR,NRAS
NEGATIVE REGULATION OF CARDIOCYTE DIFFERENTIATION%GOBP%GO:1905208	negative regulation of cardiocyte differentiation	0.01067738411173486	0.01067738411173486	+1	EGFR,SMAD4
SPECIFICATION OF SYMMETRY%GOBP%GO:0009799	specification of symmetry	0.01067738411173486	0.01067738411173486	+1	NOTCH1,TBX3,TGFBR2,SOX17
RET SIGNALING%REACTOME%R-HSA-8853659.4	RET signaling	0.01067738411173486	0.01067738411173486	+1	PIK3CA,PIK3R1,PTPN11
HEMATOPOIETIC STEM CELL PROLIFERATION%GOBP%GO:0071425	hematopoietic stem cell proliferation	0.01067738411173486	0.01067738411173486	+1	RUNX1,MECOM
MESENCHYMAL TO EPITHELIAL TRANSITION%GOBP%GO:0060231	mesenchymal to epithelial transition	0.01067738411173486	0.01067738411173486	+1	GATA3,WT1
RENAL TUBULE DEVELOPMENT%GOBP%GO:0061326	renal tubule development	0.01067738411173486	0.01067738411173486	+1	GATA3,SOX9,WT1
METANEPHRIC NEPHRON MORPHOGENESIS%GOBP%GO:0072273	metanephric nephron morphogenesis	0.01067738411173486	0.01067738411173486	+1	SOX9,WT1
NEGATIVE REGULATION OF GLIAL CELL DIFFERENTIATION%GOBP%GO:0045686	negative regulation of glial cell differentiation	0.01067738411173486	0.01067738411173486	+1	NF1,NOTCH1
PERICARDIUM DEVELOPMENT%GOBP%GO:0060039	pericardium development	0.01067738411173486	0.01067738411173486	+1	NOTCH1,WT1
REGULATION OF KERATINOCYTE MIGRATION%GOBP%GO:0051547	regulation of keratinocyte migration	0.01067738411173486	0.01067738411173486	+1	PTEN,MTOR
REGULATION OF HISTONE H3-K9 ACETYLATION%GOBP%GO:2000615	regulation of histone H3-K9 acetylation	0.01067738411173486	0.01067738411173486	+1	BRCA1,SMAD4
OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 73%5689896	Ovarian tumor domain proteases	0.01067738411173486	0.01067738411173486	+1	TP53,PTEN,APC
BONE MORPHOGENESIS%GOBP%GO:0060349	bone morphogenesis	0.01067738411173486	0.01067738411173486	+1	SOX9,FGFR2,FGFR3
PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20200810%WP4147%HOMO SAPIENS	PTF1A related regulatory pathway	0.01067738411173486	0.01067738411173486	+1	NOTCH1,CTNNB1
METANEPHRIC EPITHELIUM DEVELOPMENT%GOBP%GO:0072207	metanephric epithelium development	0.01067738411173486	0.01067738411173486	+1	SOX9,WT1
VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20200810%WP2877%HOMO SAPIENS	Vitamin D Receptor Pathway	0.01067738411173486	0.01067738411173486	+1	CDKN2A,CEBPA,CDKN1B,CCND1,CDKN1A,CDKN2C
ADRENAL GLAND DEVELOPMENT%GOBP%GO:0030325	adrenal gland development	0.01067738411173486	0.01067738411173486	+1	NF1,WT1
POSITIVE REGULATION OF PRODUCTION OF MIRNAS INVOLVED IN GENE SILENCING BY MIRNA%GOBP%GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	0.01067738411173486	0.01067738411173486	+1	TP53,EGFR
HEART VALVE FORMATION%GOBP%GO:0003188	heart valve formation	0.01067738411173486	0.01067738411173486	+1	NOTCH1,SMAD4
PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY	PID_RET_PATHWAY	0.01067738411173486	0.01067738411173486	+1	PIK3CA,PIK3R1,PTPN11
BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY	BIOCARTA_EGFR_SMRTE_PATHWAY	0.01067738411173486	0.01067738411173486	+1	EGFR,MAP3K1
SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE	Signaling events regulated by Ret tyrosine kinase	0.01067738411173486	0.01067738411173486	+1	PIK3CA,PIK3R1,PTPN11
POSITIVE REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway	0.01067738411173486	0.01067738411173486	+1	FOXA1,TAF1
DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR RESULTING IN TRANSCRIPTION OF P21 CLASS MEDIATOR%GOBP%GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	0.01067738411173486	0.01067738411173486	+1	TP53,BRCA1
REGULATION OF SIGNALING BY NODAL%REACTOME%R-HSA-1433617.1	Regulation of signaling by NODAL	0.01067738411173486	0.01067738411173486	+1	ACVR1B,ACVR2A
APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.1	Apoptotic cleavage of cell adhesion proteins	0.01067738411173486	0.01067738411173486	+1	CTNNB1,CDH1
DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.1	DAP12 interactions	0.01067738411173486	0.01067738411173486	+1	PIK3CA,PIK3R1,NRAS
POSITIVE REGULATION OF MITOTIC CELL CYCLE%GOBP%GO:0045931	positive regulation of mitotic cell cycle	0.010727141229515576	0.010727141229515576	+1	EGFR,RB1,AKT1,FOXA1,CCND1
MUSCLE STRUCTURE DEVELOPMENT%GOBP%GO:0061061	muscle structure development	0.010874390249177399	0.010874390249177399	+1	RB1,NOTCH1,WT1,PDGFRA,FGFR2,SMAD4,EGR3
NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS%GOBP%GO:0032102	negative regulation of response to external stimulus	0.010874390249177399	0.010874390249177399	+1	PTEN,GATA3,RB1,NOTCH1,CDKN1B,PDGFRA,CDKN1A
REGULATION OF MEGAKARYOCYTE DIFFERENTIATION%GOBP%GO:0045652	regulation of megakaryocyte differentiation	0.011039882394066952	0.011039882394066952	+1	RUNX1,EP300,CBFB,SIN3A
3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20200810%WP4906%HOMO SAPIENS	3q29 copy number variation syndrome	0.011039882394066952	0.011039882394066952	+1	FBXW7,AKT1,AR,ATM
REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION%GOBP%GO:0002761	regulation of myeloid leukocyte differentiation	0.011039882394066952	0.011039882394066952	+1	FBXW7,RUNX1,MTOR,TLR4
RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.2	RMTs methylate histone arginines	0.011039882394066952	0.011039882394066952	+1	ARID1A,PBRM1,DNMT3A,CCND1
PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY	PID_MYC_ACTIV_PATHWAY	0.011039882394066952	0.011039882394066952	+1	TP53,NPM1,EP300,SMAD4
POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT%GOBP%GO:0090316	positive regulation of intracellular protein transport	0.011039882394066952	0.011039882394066952	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1
ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.5	Oncogenic MAPK signaling	0.011039882394066952	0.011039882394066952	+1	KRAS,NF1,NRAS,BRAF
NUCLEAR DIVISION%GOBP%GO:0000280	nuclear division	0.011039882394066952	0.011039882394066952	+1	RB1,STAG2,ATM,CHEK2,SMC1A,SMC3,RAD21
REGULATORY CIRCUITS OF THE STAT3 SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP4538%HOMO SAPIENS	Regulatory circuits of the STAT3 signaling pathway	0.011039882394066952	0.011039882394066952	+1	EGFR,MTOR,PDGFRA,LIFR
POSITIVE REGULATION OF DEVELOPMENTAL GROWTH%GOBP%GO:0048639	positive regulation of developmental growth	0.011039882394066952	0.011039882394066952	+1	NOTCH1,WT1,ERBB4,FGFR2
ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY	ATR signaling pathway	0.011294109912768783	0.011294109912768783	+1	BRCA2,PPP2R1A,ATR
NEGATIVE REGULATION OF MITOCHONDRION ORGANIZATION%GOBP%GO:0010823	negative regulation of mitochondrion organization	0.011294109912768783	0.011294109912768783	+1	AKT1,HGF,LRRK2
SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III	Signaling events mediated by HDAC Class III	0.011294109912768783	0.011294109912768783	+1	TP53,EP300,CDKN1A
STRIATED MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0014706	striated muscle tissue development	0.011294109912768783	0.011294109912768783	+1	NOTCH1,WT1,PDGFRA,FGFR2,SMAD4
SOMATIC STEM CELL POPULATION MAINTENANCE%GOBP%GO:0035019	somatic stem cell population maintenance	0.011294109912768783	0.011294109912768783	+1	SOX9,SMAD4,SMAD2
NEGATIVE REGULATION OF BINDING%GOBP%GO:0051100	negative regulation of binding	0.011294109912768783	0.011294109912768783	+1	AKT1,LRRK2,CDKN1A,TAF1,SIN3A
CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT%GOBP%GO:0021954	central nervous system neuron development	0.011294109912768783	0.011294109912768783	+1	PTEN,ARHGAP35,FGFR2
HEDGEHOG%NETPATH%HEDGEHOG	Hedgehog	0.011294109912768783	0.011294109912768783	+1	CTNNB1,AKT1,SIN3A
REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION%GOBP%GO:2000177	regulation of neural precursor cell proliferation	0.011294109912768783	0.011294109912768783	+1	NF1,CTNNB1,LRRK2
PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY	PID_ATR_PATHWAY	0.011294109912768783	0.011294109912768783	+1	BRCA2,PPP2R1A,ATR
POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY%GOBP%GO:0090263	positive regulation of canonical Wnt signaling pathway	0.011294109912768783	0.011294109912768783	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
HEDGEHOG%IOB%HEDGEHOG	Hedgehog	0.011294109912768783	0.011294109912768783	+1	CTNNB1,AKT1,SIN3A
DOUBLE-STRAND BREAK REPAIR%GOBP%GO:0006302	double-strand break repair	0.011344642740715468	0.011344642740715468	+1	ATM,BRCA1,POLQ,CHEK2,BRCA2,RAD21
VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION	Validated targets of C-MYC transcriptional activation	0.011430284018594267	0.011430284018594267	+1	TP53,NPM1,EP300,SMAD4
REGULATION OF CELL JUNCTION ASSEMBLY%GOBP%GO:1901888	regulation of cell junction assembly	0.011430284018594267	0.011430284018594267	+1	PTEN,RUNX1,EPHA3,CBFB
OSSIFICATION%GOBP%GO:0001503	ossification	0.011619407416493822	0.011619407416493822	+1	EGFR,NF1,RUNX1,FGFR2,FGFR3
GM-CSF%IOB%GM-CSF	GM-CSF	0.011937023684133276	0.011937023684133276	+1	PIK3R1,AKT1,KIT,PTPN11
HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.2	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.011987252081133545	0.011987252081133545	+1	ATM,BRCA1,BRCA2,ATR,HIST1H2BD
ST_B_CELL_ANTIGEN_RECEPTOR%MSIGDB_C2%ST_B_CELL_ANTIGEN_RECEPTOR	ST_B_CELL_ANTIGEN_RECEPTOR	0.012041600412588891	0.012041600412588891	+1	PIK3CA,PIK3R1,AKT1
REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA%GOBP%GO:0090199	regulation of release of cytochrome c from mitochondria	0.012041600412588891	0.012041600412588891	+1	TP53,AKT1,HGF
MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20200810%WP3937%HOMO SAPIENS	Microglia Pathogen Phagocytosis Pathway	0.012041600412588891	0.012041600412588891	+1	PIK3CA,PIK3R1,PIK3CG
MTOR SIGNALLING%REACTOME%R-HSA-165159.6	MTOR signalling	0.012041600412588891	0.012041600412588891	+1	STK11,AKT1,MTOR
NEGATIVE REGULATION OF NUCLEAR DIVISION%GOBP%GO:0051784	negative regulation of nuclear division	0.012041600412588891	0.012041600412588891	+1	APC,ATM,ATRX
REGULATION OF STEM CELL PROLIFERATION%GOBP%GO:0072091	regulation of stem cell proliferation	0.012041600412588891	0.012041600412588891	+1	NF1,CTNNB1,LRRK2
RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20200810%WP2290%HOMO SAPIENS	RalA downstream regulated genes	0.012221964881368973	0.012221964881368973	+1	KRAS,NRAS
SIGNAL TRANSDUCTION INVOLVED IN G2 DNA DAMAGE CHECKPOINT%GOBP%GO:0072425	signal transduction involved in G2 DNA damage checkpoint	0.012221964881368973	0.012221964881368973	+1	ATM,BRCA1
NEGATIVE REGULATION OF CARDIAC MUSCLE HYPERTROPHY%GOBP%GO:0010614	negative regulation of cardiac muscle hypertrophy	0.012221964881368973	0.012221964881368973	+1	NOTCH1,SMAD4
MYELINATION IN PERIPHERAL NERVOUS SYSTEM%GOBP%GO:0022011	myelination in peripheral nervous system	0.012221964881368973	0.012221964881368973	+1	NF1,PRX
GLIAL CELL DIFFERENTIATION%GOBP%GO:0010001	glial cell differentiation	0.012221964881368973	0.012221964881368973	+1	PTEN,NF1,SOX9,PRX
AXONAL FASCICULATION%GOBP%GO:0007413	axonal fasciculation	0.012221964881368973	0.012221964881368973	+1	ARHGAP35,EPHA3
SEX DETERMINATION%GOBP%GO:0007530	sex determination	0.012221964881368973	0.012221964881368973	+1	SOX9,WT1
REGULATION OF EPITHELIAL CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:2000696	regulation of epithelial cell differentiation involved in kidney development	0.012221964881368973	0.012221964881368973	+1	GATA3,CTNNB1
BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY	BIOCARTA_VDR_PATHWAY	0.012221964881368973	0.012221964881368973	+1	EP300,NCOR1
NEGATIVE REGULATION OF MUSCLE HYPERTROPHY%GOBP%GO:0014741	negative regulation of muscle hypertrophy	0.012221964881368973	0.012221964881368973	+1	NOTCH1,SMAD4
SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 73%180336	SHC1 events in EGFR signaling	0.012221964881368973	0.012221964881368973	+1	EGFR,NRAS
DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION RESULTING IN TRANSCRIPTION%GOBP%GO:0042772	DNA damage response, signal transduction resulting in transcription	0.012221964881368973	0.012221964881368973	+1	TP53,BRCA1
SCHWANN CELL DEVELOPMENT%GOBP%GO:0014044	Schwann cell development	0.012221964881368973	0.012221964881368973	+1	NF1,PRX
PI METABOLISM%REACTOME DATABASE ID RELEASE 73%1483255	PI Metabolism	0.012221964881368973	0.012221964881368973	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
NEGATIVE REGULATION OF MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:1905331	negative regulation of morphogenesis of an epithelium	0.012221964881368973	0.012221964881368973	+1	PTEN,GATA3
PERIPHERAL NERVOUS SYSTEM AXON ENSHEATHMENT%GOBP%GO:0032292	peripheral nervous system axon ensheathment	0.012221964881368973	0.012221964881368973	+1	NF1,PRX
TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 73%8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.012221964881368973	0.012221964881368973	+1	EGFR,KIT
REGULATION OF EMBRYONIC DEVELOPMENT%GOBP%GO:0045995	regulation of embryonic development	0.012221964881368973	0.012221964881368973	+1	GATA3,CTNNB1,FOXA2,SOX17
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.1	TP53 Regulates Transcription of Caspase Activators and Caspases	0.012221964881368973	0.012221964881368973	+1	TP53,ATM
POSITIVE REGULATION OF CHROMATIN ORGANIZATION%GOBP%GO:1905269	positive regulation of chromatin organization	0.012221964881368973	0.012221964881368973	+1	CTNNB1,BRCA1,SMAD4,SIN3A
REGULATION OF HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION%GOBP%GO:1901532	regulation of hematopoietic progenitor cell differentiation	0.012221964881368973	0.012221964881368973	+1	GATA3,NOTCH1,RUNX1,CBFB
ANIMAL ORGAN FORMATION%GOBP%GO:0048645	animal organ formation	0.012221964881368973	0.012221964881368973	+1	FGFR2,SOX17
NEURON PROJECTION FASCICULATION%GOBP%GO:0106030	neuron projection fasciculation	0.012221964881368973	0.012221964881368973	+1	ARHGAP35,EPHA3
LNCRNA-MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20200810%WP3672%HOMO SAPIENS	LncRNA-mediated mechanisms of therapeutic resistance	0.012221964881368973	0.012221964881368973	+1	TP53,CDKN1A
REGULATION OF MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:1905330	regulation of morphogenesis of an epithelium	0.012514227061661092	0.012514227061661092	+1	PTEN,GATA3,SOX9,HGF,MTOR
SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 73%3899300	SUMOylation of transcription cofactors	0.012667132202985711	0.012667132202985711	+1	NPM1,EP300,SIN3A
REGULATION OF PROTEIN TARGETING TO MITOCHONDRION%GOBP%GO:1903214	regulation of protein targeting to mitochondrion	0.012667132202985711	0.012667132202985711	+1	FBXW7,BAP1,LRRK2
LOCOMOTORY BEHAVIOR%GOBP%GO:0007626	locomotory behavior	0.012667132202985711	0.012667132202985711	+1	PTEN,FOXA2,NCOR1
PERIPHERAL NERVOUS SYSTEM DEVELOPMENT%GOBP%GO:0007422	peripheral nervous system development	0.012667132202985711	0.012667132202985711	+1	NF1,RUNX1,PRX
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 73%381340	Transcriptional regulation of white adipocyte differentiation	0.012696796109870014	0.012696796109870014	+1	CEBPA,EP300,TBL1XR1,NCOR1
TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.4	TP53 Regulates Metabolic Genes	0.012696796109870014	0.012696796109870014	+1	TP53,PTEN,AKT1,MTOR
FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 73%2454202	Fc epsilon receptor (FCERI) signaling	0.012856117490000867	0.012856117490000867	+1	PIK3CA,PIK3R1,MAP3K1,NRAS,MAP2K4
IL3%NETPATH%IL3	IL3	0.013217886673674652	0.013217886673674652	+1	PIK3R1,RB1,AKT1,PTPN11
CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES%GOBP%GO:0034614	cellular response to reactive oxygen species	0.013217886673674652	0.013217886673674652	+1	EGFR,NFE2L2,AKT1,PDGFRA
CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 73%3371556	Cellular response to heat stress	0.013217886673674652	0.013217886673674652	+1	ATM,MTOR,EP300,ATR
SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.1	Signaling downstream of RAS mutants	0.013411792718401445	0.013411792718401445	+1	KRAS,NRAS,BRAF
NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.3	Negative regulation of MAPK pathway	0.013411792718401445	0.013411792718401445	+1	NRAS,BRAF,PPP2R1A
SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.2	Signaling by RAS mutants	0.013411792718401445	0.013411792718401445	+1	KRAS,NRAS,BRAF
NEGATIVE REGULATION OF STRESS-ACTIVATED MAPK CASCADE%GOBP%GO:0032873	negative regulation of stress-activated MAPK cascade	0.013411792718401445	0.013411792718401445	+1	MAPK8IP1,MECOM,NCOR1
FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP4136%HOMO SAPIENS	Fibrin Complement Receptor 3 Signaling Pathway	0.013411792718401445	0.013411792718401445	+1	PIK3CA,AKT1,TLR4
NEGATIVE REGULATION OF STRESS-ACTIVATED PROTEIN KINASE SIGNALING CASCADE%GOBP%GO:0070303	negative regulation of stress-activated protein kinase signaling cascade	0.013411792718401445	0.013411792718401445	+1	MAPK8IP1,MECOM,NCOR1
IL-2 SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP49%HOMO SAPIENS	IL-2 Signaling Pathway	0.013411792718401445	0.013411792718401445	+1	PIK3R1,AKT1,PTPN11
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.1	Signaling by moderate kinase activity BRAF mutants	0.013411792718401445	0.013411792718401445	+1	KRAS,NRAS,BRAF
NEGATIVE REGULATION OF PROTEIN DEPOLYMERIZATION%GOBP%GO:1901880	negative regulation of protein depolymerization	0.013411792718401445	0.013411792718401445	+1	PIK3CA,APC,NAV3
POSITIVE REGULATION OF NOTCH SIGNALING PATHWAY%GOBP%GO:0045747	positive regulation of Notch signaling pathway	0.013411792718401445	0.013411792718401445	+1	NOTCH1,ELF3,EP300
PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.2	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.013411792718401445	0.013411792718401445	+1	KRAS,NRAS,BRAF
MITOTIC SPINDLE ORGANIZATION%GOBP%GO:0007052	mitotic spindle organization	0.013679045836582634	0.013679045836582634	+1	STAG2,CHEK2,SMC1A,SMC3
INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031	Inflammation mediated by chemokine and cytokine signaling pathway	0.013698310163414712	0.013698310163414712	+1	PIK3CA,PTEN,KRAS,NRAS,AKT1,PIK3CG
BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY	BIOCARTA_CBL_PATHWAY	0.013983435755169402	0.013983435755169402	+1	EGFR,PDGFRA
GENETIC IMPRINTING%GOBP%GO:0071514	genetic imprinting	0.013983435755169402	0.013983435755169402	+1	DNMT3A,CTCF
POSITIVE REGULATION OF CELLULAR RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1900409	positive regulation of cellular response to oxidative stress	0.013983435755169402	0.013983435755169402	+1	FBXW7,TLR4
NEUROINFLAMMATION%WIKIPATHWAYS_20200810%WP4919%HOMO SAPIENS	Neuroinflammation	0.013983435755169402	0.013983435755169402	+1	MTOR,TLR4
NEGATIVE REGULATION OF KIDNEY DEVELOPMENT%GOBP%GO:0090185	negative regulation of kidney development	0.013983435755169402	0.013983435755169402	+1	GATA3,WT1
RESPONSE TO UV-B%GOBP%GO:0010224	response to UV-B	0.013983435755169402	0.013983435755169402	+1	STK11,CDKN1A
NEGATIVE REGULATION OF NEUROLOGICAL SYSTEM PROCESS%GOBP%GO:0031645	negative regulation of neurological system process	0.013983435755169402	0.013983435755169402	+1	PTEN,LRRK2
NEGATIVE REGULATION OF HISTONE ACETYLATION%GOBP%GO:0035067	negative regulation of histone acetylation	0.013983435755169402	0.013983435755169402	+1	BRCA1,SIN3A
TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20200810%WP4211%HOMO SAPIENS	Transcriptional cascade regulating adipogenesis	0.013983435755169402	0.013983435755169402	+1	GATA3,CEBPA
BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY	BIOCARTA_P27_PATHWAY	0.013983435755169402	0.013983435755169402	+1	RB1,CDKN1B
METANEPHROS MORPHOGENESIS%GOBP%GO:0003338	metanephros morphogenesis	0.013983435755169402	0.013983435755169402	+1	SOX9,WT1
GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.3	GRB2 events in ERBB2 signaling	0.013983435755169402	0.013983435755169402	+1	EGFR,NRAS
PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 73%8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	0.013983435755169402	0.013983435755169402	+1	ARHGAP35,NRAS
HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20200810%WP186%HOMO SAPIENS	Homologous recombination	0.013983435755169402	0.013983435755169402	+1	ATM,BRCA2
REGULATION OF NUCLEAR CELL CYCLE DNA REPLICATION%GOBP%GO:0033262	regulation of nuclear cell cycle DNA replication	0.013983435755169402	0.013983435755169402	+1	ATRX,CHEK2
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 73%113501	Inhibition of replication initiation of damaged DNA by RB1 E2F1	0.013983435755169402	0.013983435755169402	+1	RB1,PPP2R1A
NEGATIVE REGULATION OF CENTROSOME DUPLICATION%GOBP%GO:0010826	negative regulation of centrosome duplication	0.013983435755169402	0.013983435755169402	+1	NPM1,BRCA1
POSITIVE REGULATION OF PLASMA MEMBRANE BOUNDED CELL PROJECTION ASSEMBLY%GOBP%GO:0120034	positive regulation of plasma membrane bounded cell projection assembly	0.01407462620928694	0.01407462620928694	+1	PIK3CA,APC,PIK3R1,ARHGAP35
CONNECTIVE TISSUE DEVELOPMENT%GOBP%GO:0061448	connective tissue development	0.01407462620928694	0.01407462620928694	+1	RUNX1,SOX9,ARID5B,FGFR3
INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 73%512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.014083821997025897	0.014083821997025897	+1	PIK3CA,PIK3R1,PTPN11
FAS LIGAND (FASL) PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS (HSP) REGULATION%WIKIPATHWAYS_20200810%WP314%HOMO SAPIENS	Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation	0.014083821997025897	0.014083821997025897	+1	RB1,MAP3K1,MAP2K4
REGULATION OF OSTEOCLAST DIFFERENTIATION%GOBP%GO:0045670	regulation of osteoclast differentiation	0.014083821997025897	0.014083821997025897	+1	FBXW7,MTOR,TLR4
POSITIVE REGULATION OF PHOSPHOLIPASE C ACTIVITY%GOBP%GO:0010863	positive regulation of phospholipase C activity	0.014083821997025897	0.014083821997025897	+1	EGFR,KIT,PDGFRA
CARDIAC MUSCLE TISSUE MORPHOGENESIS%GOBP%GO:0055008	cardiac muscle tissue morphogenesis	0.014083821997025897	0.014083821997025897	+1	NOTCH1,FGFR2,SMAD4
CELLULAR RESPONSE TO RETINOIC ACID%GOBP%GO:0071300	cellular response to retinoic acid	0.014083821997025897	0.014083821997025897	+1	EPHA3,SOX9,ATM
NEGATIVE REGULATION OF CELL-CELL ADHESION%GOBP%GO:0022408	negative regulation of cell-cell adhesion	0.014142901577819613	0.014142901577819613	+1	NOTCH1,CDH1,RUNX1,AKT1,CBFB
HCMV INFECTION%REACTOME%R-HSA-9609646.2	HCMV Infection	0.014142901577819613	0.014142901577819613	+1	EGFR,HIST1H2BD,TBL1XR1,NCOR1,EZH2
RESPONSE TO METAL ION%GOBP%GO:0010038	response to metal ion	0.014451357908054553	0.014451357908054553	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
HALLMARK_MITOTIC_SPINDLE%MSIGDB_C2%HALLMARK_MITOTIC_SPINDLE	HALLMARK_MITOTIC_SPINDLE	0.014451357908054553	0.014451357908054553	+1	APC,NF1,CRIPAK,BRCA2,SMC1A,SMC3
HALLMARK_ALLOGRAFT_REJECTION%MSIGDB_C2%HALLMARK_ALLOGRAFT_REJECTION	HALLMARK_ALLOGRAFT_REJECTION	0.014451357908054553	0.014451357908054553	+1	EGFR,CDKN2A,NPM1,AKT1,BRCA1,ACVR2A
VIRAL ACUTE MYOCARDITIS%WIKIPATHWAYS_20200810%WP4298%HOMO SAPIENS	Viral Acute Myocarditis	0.01452321034469152	0.01452321034469152	+1	PIK3R1,AKT1,TLR4,CCND1
BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY	BIOCARTA_MAPK_PATHWAY	0.01452321034469152	0.01452321034469152	+1	MAP3K1,MAP2K4,CEBPA,BRAF
REGULATION OF DNA RECOMBINATION%GOBP%GO:0000018	regulation of DNA recombination	0.01452321034469152	0.01452321034469152	+1	POLQ,HIST1H1C,SETD2,ERCC2
MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 73%912446	Meiotic recombination	0.01452321034469152	0.01452321034469152	+1	ATM,BRCA1,BRCA2,HIST1H2BD
CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY	Ceramide signaling pathway	0.014903361968223837	0.014903361968223837	+1	MAP3K1,MAP2K4,AKT1
INTERLEUKIN-11 SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP2332%HOMO SAPIENS	Interleukin-11 Signaling Pathway	0.014903361968223837	0.014903361968223837	+1	PIK3R1,AKT1,PTPN11
FSH%NETPATH%FSH	FSH	0.014903361968223837	0.014903361968223837	+1	EGFR,AKT1,MTOR
INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING	Integrin-linked kinase signaling	0.014903361968223837	0.014903361968223837	+1	CTNNB1,AKT1,CCND1
REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS%GOBP%GO:1900180	regulation of protein localization to nucleus	0.015037549917518834	0.015037549917518834	+1	PIK3R1,CDH1,AKT1,SIN3A
GASTRULATION%GOBP%GO:0007369	gastrulation	0.015037549917518834	0.015037549917518834	+1	SETD2,FOXA2,SOX17,SMAD2
TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY%GOBP%GO:0007179	transforming growth factor beta receptor signaling pathway	0.015037549917518834	0.015037549917518834	+1	SMAD4,USP9X,TGFBR2,SMAD2
NEURON PROJECTION GUIDANCE%GOBP%GO:0097485	neuron projection guidance	0.015037549917518834	0.015037549917518834	+1	PIK3CA,PIK3R1,NOTCH1,ARHGAP35,EPHA3,PTPN11
AXON GUIDANCE%GOBP%GO:0007411	axon guidance	0.015037549917518834	0.015037549917518834	+1	PIK3CA,PIK3R1,NOTCH1,ARHGAP35,EPHA3,PTPN11
MUSCLE ORGAN DEVELOPMENT%GOBP%GO:0007517	muscle organ development	0.015306840697501045	0.015306840697501045	+1	NOTCH1,WT1,FGFR2,SMAD4,EGR3
BRANCHING INVOLVED IN BLOOD VESSEL MORPHOGENESIS%GOBP%GO:0001569	branching involved in blood vessel morphogenesis	0.01566457112294597	0.01566457112294597	+1	CTNNB1,TGFBR2
TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.2	Truncations of AMER1 destabilize the destruction complex	0.01566457112294597	0.01566457112294597	+1	APC,PPP2R1A
APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.1	APC truncation mutants have impaired AXIN binding	0.01566457112294597	0.01566457112294597	+1	APC,PPP2R1A
AXIN MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX, ACTIVATING WNT SIGNALING%REACTOME DATABASE ID RELEASE 73%4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	0.01566457112294597	0.01566457112294597	+1	APC,PPP2R1A
DEVELOPMENTAL CELL GROWTH%GOBP%GO:0048588	developmental cell growth	0.01566457112294597	0.01566457112294597	+1	CTNNB1,SOX9,USP9X
OLFACTORY BULB DEVELOPMENT%GOBP%GO:0021772	olfactory bulb development	0.01566457112294597	0.01566457112294597	+1	ERBB4,LRRK2
RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.1	RUNX3 regulates NOTCH signaling	0.01566457112294597	0.01566457112294597	+1	NOTCH1,EP300
FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 73%5654706	FRS-mediated FGFR3 signaling	0.01566457112294597	0.01566457112294597	+1	NRAS,PTPN11
NUCLEOSOME POSITIONING%GOBP%GO:0016584	nucleosome positioning	0.01566457112294597	0.01566457112294597	+1	CTCF,HIST1H1C
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 73%6804759	Regulation of TP53 Activity through Association with Co-factors	0.01566457112294597	0.01566457112294597	+1	TP53,AKT1
AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.1	AXIN missense mutants destabilize the destruction complex	0.01566457112294597	0.01566457112294597	+1	APC,PPP2R1A
TRUNCATED APC MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-4839744.1	truncated APC mutants destabilize the destruction complex	0.01566457112294597	0.01566457112294597	+1	APC,PPP2R1A
LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.2	LXR-mediated signaling	0.01566457112294597	0.01566457112294597	+1	EP300,TBL1XR1,NCOR1
PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY	PID_RHOA_PATHWAY	0.01566457112294597	0.01566457112294597	+1	PTEN,MAP2K4,CDKN1B
REGULATION OF RETINOIC ACID RECEPTOR SIGNALING PATHWAY%GOBP%GO:0048385	regulation of retinoic acid receptor signaling pathway	0.01566457112294597	0.01566457112294597	+1	ASXL1,EZH2
ANTERIOR/POSTERIOR AXIS SPECIFICATION, EMBRYO%GOBP%GO:0008595	anterior/posterior axis specification, embryo	0.01566457112294597	0.01566457112294597	+1	TBX3,WT1
BLASTODERM SEGMENTATION%GOBP%GO:0007350	blastoderm segmentation	0.01566457112294597	0.01566457112294597	+1	TBX3,WT1
AMER1 MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 73%4839748	AMER1 mutants destabilize the destruction complex	0.01566457112294597	0.01566457112294597	+1	APC,PPP2R1A
EMBRYONIC HEMOPOIESIS%GOBP%GO:0035162	embryonic hemopoiesis	0.01566457112294597	0.01566457112294597	+1	KIT,TGFBR2
JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY	JNK signaling in the CD4+ TCR pathway	0.01566457112294597	0.01566457112294597	+1	MAP3K1,MAP2K4
REGULATION OF COLD-INDUCED THERMOGENESIS%GOBP%GO:0120161	regulation of cold-induced thermogenesis	0.01566457112294597	0.01566457112294597	+1	APC,RB1,NOTCH1,STK11,TLR4
REGULATION OF HISTONE ACETYLATION%GOBP%GO:0035065	regulation of histone acetylation	0.01566457112294597	0.01566457112294597	+1	BRCA1,SMAD4,SIN3A
TRIPARTITE REGIONAL SUBDIVISION%GOBP%GO:0007351	tripartite regional subdivision	0.01566457112294597	0.01566457112294597	+1	TBX3,WT1
PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY	PID_TCR_JNK_PATHWAY	0.01566457112294597	0.01566457112294597	+1	MAP3K1,MAP2K4
2-OXOGLUTARATE METABOLIC PROCESS%GOBP%GO:0006103	2-oxoglutarate metabolic process	0.01566457112294597	0.01566457112294597	+1	IDH1,IDH2
ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY	Atypical NF-kappaB pathway	0.01566457112294597	0.01566457112294597	+1	PIK3CA,PIK3R1
RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY	RhoA signaling pathway	0.01566457112294597	0.01566457112294597	+1	PTEN,MAP2K4,CDKN1B
NEGATIVE REGULATION OF PEPTIDYL-LYSINE ACETYLATION%GOBP%GO:2000757	negative regulation of peptidyl-lysine acetylation	0.01566457112294597	0.01566457112294597	+1	BRCA1,SIN3A
TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.2	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation	0.015974841169106815	0.015974841169106815	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
SIG_BCR_SIGNALING_PATHWAY%MSIGDB_C2%SIG_BCR_SIGNALING_PATHWAY	SIG_BCR_SIGNALING_PATHWAY	0.01646470271817389	0.01646470271817389	+1	PIK3CA,PIK3R1,AKT1
REGULATION OF PHOSPHOLIPASE C ACTIVITY%GOBP%GO:1900274	regulation of phospholipase C activity	0.01646470271817389	0.01646470271817389	+1	EGFR,KIT,PDGFRA
POSITIVE REGULATION OF REPRODUCTIVE PROCESS%GOBP%GO:2000243	positive regulation of reproductive process	0.01646470271817389	0.01646470271817389	+1	SOX9,WT1,ACVR1B
POSITIVE REGULATION OF ALPHA-BETA T CELL ACTIVATION%GOBP%GO:0046635	positive regulation of alpha-beta T cell activation	0.01646470271817389	0.01646470271817389	+1	RUNX1,TGFBR2,CBFB
CELL GROWTH%GOBP%GO:0016049	cell growth	0.01646470271817389	0.01646470271817389	+1	CTNNB1,SOX9,USP9X
FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 73%201722	Formation of the beta-catenin:TCF transactivating complex	0.016506690812639183	0.016506690812639183	+1	CTNNB1,EP300,HIST1H2BD,AXIN2
TELENCEPHALON DEVELOPMENT%GOBP%GO:0021537	telencephalon development	0.016506690812639183	0.016506690812639183	+1	PTEN,NF1,ERBB4,LRRK2
MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 73%975155	MyD88 dependent cascade initiated on endosome	0.016506690812639183	0.016506690812639183	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.2	Toll Like Receptor 7 8 (TLR7 8) Cascade	0.016506690812639183	0.016506690812639183	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
T-CELL ANTIGEN RECEPTOR (TCR)  SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP69%HOMO SAPIENS	T-Cell antigen Receptor (TCR)  Signaling Pathway	0.016506690812639183	0.016506690812639183	+1	PIK3R1,GATA3,AKT1,PTPN11
NEGATIVE REGULATION OF DNA-BINDING TRANSCRIPTION FACTOR ACTIVITY%GOBP%GO:0043433	negative regulation of DNA-binding transcription factor activity	0.0167561857273003	0.0167561857273003	+1	CDKN2A,RB1,KEAP1,FOXA2,TAF1
REGULATION OF RESPONSE TO CYTOKINE STIMULUS%GOBP%GO:0060759	regulation of response to cytokine stimulus	0.0167561857273003	0.0167561857273003	+1	RUNX1,TLR4,CBFB,PTPN11,LIFR
ANTERIOR/POSTERIOR PATTERN SPECIFICATION%GOBP%GO:0009952	anterior/posterior pattern specification	0.01710207587042555	0.01710207587042555	+1	TBX3,WT1,FOXA2,SMAD2
CORTICOTROPIN-RELEASING HORMONE SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP2355%HOMO SAPIENS	Corticotropin-releasing hormone signaling pathway	0.01710207587042555	0.01710207587042555	+1	CTNNB1,AKT1,BRAF,TLR4
CELLULAR RESPONSE TO FIBROBLAST GROWTH FACTOR STIMULUS%GOBP%GO:0044344	cellular response to fibroblast growth factor stimulus	0.01710207587042555	0.01710207587042555	+1	FGFR2,FGFR3,PTPN11,EGR3
REGIONALIZATION%GOBP%GO:0003002	regionalization	0.017187382125601856	0.017187382125601856	+1	TBX3,WT1,FGFR2,FOXA2,SMAD2
NRF2 PATHWAY%WIKIPATHWAYS_20200810%WP2884%HOMO SAPIENS	NRF2 pathway	0.017187382125601856	0.017187382125601856	+1	KEAP1,NFE2L2,EPHA3,HGF,TGFBR2
BDNF%IOB%BDNF	BDNF	0.017270873782912446	0.017270873782912446	+1	CTNNB1,AKT1,MTOR
MUSCLE ORGAN MORPHOGENESIS%GOBP%GO:0048644	muscle organ morphogenesis	0.017270873782912446	0.017270873782912446	+1	NOTCH1,FGFR2,SMAD4
LIPID PHOSPHORYLATION%GOBP%GO:0046834	lipid phosphorylation	0.017270873782912446	0.017270873782912446	+1	PIK3CA,PIK3R1,PIK3CG
REGULATION OF ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0046637	regulation of alpha-beta T cell differentiation	0.017270873782912446	0.017270873782912446	+1	RUNX1,TGFBR2,CBFB
PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY	PID_ILK_PATHWAY	0.017270873782912446	0.017270873782912446	+1	CTNNB1,AKT1,CCND1
LIMB MORPHOGENESIS%GOBP%GO:0035108	limb morphogenesis	0.017270873782912446	0.017270873782912446	+1	CTNNB1,TBX3,FGFR2
APPENDAGE MORPHOGENESIS%GOBP%GO:0035107	appendage morphogenesis	0.017270873782912446	0.017270873782912446	+1	CTNNB1,TBX3,FGFR2
MUSCLE TISSUE MORPHOGENESIS%GOBP%GO:0060415	muscle tissue morphogenesis	0.017270873782912446	0.017270873782912446	+1	NOTCH1,FGFR2,SMAD4
METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20200810%WP2249%HOMO SAPIENS	Metastatic brain tumor	0.01747287540136118	0.01747287540136118	+1	TP53,PIK3R1
PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY	PID_ERBB_NETWORK_PATHWAY	0.01747287540136118	0.01747287540136118	+1	EGFR,ERBB4
SCHWANN CELL DIFFERENTIATION%GOBP%GO:0014037	Schwann cell differentiation	0.01747287540136118	0.01747287540136118	+1	NF1,PRX
POSITIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1902884	positive regulation of response to oxidative stress	0.01747287540136118	0.01747287540136118	+1	FBXW7,TLR4
REGULATION OF JNK CASCADE%GOBP%GO:0046328	regulation of JNK cascade	0.01747287540136118	0.01747287540136118	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT%GOBP%GO:0045992	negative regulation of embryonic development	0.01747287540136118	0.01747287540136118	+1	GATA3,CTNNB1
NEGATIVE REGULATION OF CENTROSOME CYCLE%GOBP%GO:0046606	negative regulation of centrosome cycle	0.01747287540136118	0.01747287540136118	+1	NPM1,BRCA1
REGULATION OF HISTONE H3-K9 METHYLATION%GOBP%GO:0051570	regulation of histone H3-K9 methylation	0.01747287540136118	0.01747287540136118	+1	ATRX,BRCA1
SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20200810%WP4814%HOMO SAPIENS	Somatic Sex determination	0.01747287540136118	0.01747287540136118	+1	SOX9,WT1
NEGATIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA%GOBP%GO:0090201	negative regulation of release of cytochrome c from mitochondria	0.01747287540136118	0.01747287540136118	+1	AKT1,HGF
NEGATIVE REGULATION OF CHONDROCYTE DIFFERENTIATION%GOBP%GO:0032331	negative regulation of chondrocyte differentiation	0.01747287540136118	0.01747287540136118	+1	SOX9,PTPN11
NEGATIVE REGULATION OF COFACTOR METABOLIC PROCESS%GOBP%GO:0051195	negative regulation of cofactor metabolic process	0.01747287540136118	0.01747287540136118	+1	TP53,NCOR1
ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK	ErbB receptor signaling network	0.01747287540136118	0.01747287540136118	+1	EGFR,ERBB4
POSITIVE REGULATION OF DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	0.01747287540136118	0.01747287540136118	+1	ATM,ATR
OLFACTORY LOBE DEVELOPMENT%GOBP%GO:0021988	olfactory lobe development	0.01747287540136118	0.01747287540136118	+1	ERBB4,LRRK2
RESPONSE TO MUSCLE STRETCH%GOBP%GO:0035994	response to muscle stretch	0.01747287540136118	0.01747287540136118	+1	PIK3CA,CTNNB1
MITOTIC CELL CYCLE ARREST%GOBP%GO:0071850	mitotic cell cycle arrest	0.01747287540136118	0.01747287540136118	+1	CDKN1B,CDKN1A
ANDROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0030521	androgen receptor signaling pathway	0.01747287540136118	0.01747287540136118	+1	ARID1A,AR
BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY	BIOCARTA_HIF_PATHWAY	0.01747287540136118	0.01747287540136118	+1	VHL,EP300
NEGATIVE REGULATION OF TORC1 SIGNALING%GOBP%GO:1904262	negative regulation of TORC1 signaling	0.01747287540136118	0.01747287540136118	+1	STK11,ATM
TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 73%168898	Toll-like Receptor Cascades	0.01784813359475226	0.01784813359475226	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
ESTABLISHMENT OF RNA LOCALIZATION%GOBP%GO:0051236	establishment of RNA localization	0.01784813359475226	0.01784813359475226	+1	NPM1,ATM,U2AF1,TGFBR2,ATR
TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.1	Toll Like Receptor TLR1:TLR2 Cascade	0.01796128545140608	0.01796128545140608	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY	PID_AJDISS_2PATHWAY	0.01796128545140608	0.01796128545140608	+1	EGFR,CTNNB1,CDH1
TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.1	Toll Like Receptor TLR6:TLR2 Cascade	0.01796128545140608	0.01796128545140608	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REGULATION OF CELL-MATRIX ADHESION%GOBP%GO:0001952	regulation of cell-matrix adhesion	0.01796128545140608	0.01796128545140608	+1	PTEN,NF1,CDKN2A,EPHA3
SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.2	Signaling by NOTCH3	0.01796128545140608	0.01796128545140608	+1	EGFR,NOTCH1,EP300
DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20200810%WP2848%HOMO SAPIENS	Differentiation Pathway	0.01796128545140608	0.01796128545140608	+1	NOTCH1,HGF,KIT
TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.1	Toll Like Receptor 2 (TLR2) Cascade	0.01796128545140608	0.01796128545140608	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
NEGATIVE REGULATION OF ERK1 AND ERK2 CASCADE%GOBP%GO:0070373	negative regulation of ERK1 and ERK2 cascade	0.01796128545140608	0.01796128545140608	+1	PTEN,TLR4,SMAD4
MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-166058.3	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.01796128545140608	0.01796128545140608	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY	Posttranslational regulation of adherens junction stability and dissassembly	0.01796128545140608	0.01796128545140608	+1	EGFR,CTNNB1,CDH1
RESPONSE TO FIBROBLAST GROWTH FACTOR%GOBP%GO:0071774	response to fibroblast growth factor	0.01796128545140608	0.01796128545140608	+1	FGFR2,FGFR3,PTPN11,EGR3
TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-HSA-168138.1	Toll Like Receptor 9 (TLR9) Cascade	0.01862978231134898	0.01862978231134898	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REGULATION OF PEPTIDYL-LYSINE ACETYLATION%GOBP%GO:2000756	regulation of peptidyl-lysine acetylation	0.018932872958180667	0.018932872958180667	+1	BRCA1,SMAD4,SIN3A
CELLULAR RESPONSE TO ALCOHOL%GOBP%GO:0097306	cellular response to alcohol	0.018932872958180667	0.018932872958180667	+1	CTNNB1,CDH1,BRCA1
IL-3 SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP286%HOMO SAPIENS	IL-3 Signaling Pathway	0.018932872958180667	0.018932872958180667	+1	PIK3R1,AKT1,PTPN11
POSITIVE REGULATION OF TELOMERE MAINTENANCE%GOBP%GO:0032206	positive regulation of telomere maintenance	0.018932872958180667	0.018932872958180667	+1	ATM,ATRX,ATR
POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT%GOBP%GO:0046824	positive regulation of nucleocytoplasmic transport	0.018932872958180667	0.018932872958180667	+1	TP53,PIK3R1,CDH1
REGULATION OF UBIQUITIN-PROTEIN TRANSFERASE ACTIVITY%GOBP%GO:0051438	regulation of ubiquitin-protein transferase activity	0.018932872958180667	0.018932872958180667	+1	PTEN,FBXW7,RPL5
REGULATION OF CARBOHYDRATE METABOLIC PROCESS%GOBP%GO:0006109	regulation of carbohydrate metabolic process	0.019154190984357212	0.019154190984357212	+1	TP53,AKT1,EP300,FOXA2,NCOR1
SPINDLE ORGANIZATION%GOBP%GO:0007051	spindle organization	0.019154190984357212	0.019154190984357212	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
DOUBLE-STRAND BREAK REPAIR VIA HOMOLOGOUS RECOMBINATION%GOBP%GO:0000724	double-strand break repair via homologous recombination	0.01919686647085372	0.01919686647085372	+1	BRCA1,POLQ,BRCA2,RAD21
MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.2	MyD88-independent TLR4 cascade	0.01919686647085372	0.01919686647085372	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 73%937061	TRIF(TICAM1)-mediated TLR4 signaling	0.01919686647085372	0.01919686647085372	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.2	Platelet sensitization by LDL	0.019389838569166675	0.019389838569166675	+1	PPP2R1A,PTPN11
GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 73%881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.019389838569166675	0.019389838569166675	+1	EGFR,NRAS
MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20200810%WP4928%HOMO SAPIENS	MAPK pathway in congenital thyroid cancer	0.019389838569166675	0.019389838569166675	+1	KRAS,BRAF
FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 73%9614657	FOXO-mediated transcription of cell death genes	0.019389838569166675	0.019389838569166675	+1	STK11,EP300
NEGATIVE REGULATION OF CD4-POSITIVE, ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	0.019389838569166675	0.019389838569166675	+1	RUNX1,CBFB
FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 73%5654693	FRS-mediated FGFR1 signaling	0.019389838569166675	0.019389838569166675	+1	NRAS,PTPN11
LEUKOCYTE DIFFERENTIATION%GOBP%GO:0002521	leukocyte differentiation	0.019389838569166675	0.019389838569166675	+1	GATA3,FLT3,CEBPA,ATM,KIT,TGFBR2
NEGATIVE REGULATION OF CARTILAGE DEVELOPMENT%GOBP%GO:0061037	negative regulation of cartilage development	0.019389838569166675	0.019389838569166675	+1	SOX9,PTPN11
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%R-HSA-936964.2	Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon	0.019389838569166675	0.019389838569166675	+1	TLR4,PTPN11
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME DATABASE ID RELEASE 73%1839117	Signaling by cytosolic FGFR1 fusion mutants	0.019389838569166675	0.019389838569166675	+1	PIK3CA,PIK3R1
MAINTENANCE OF GASTROINTESTINAL EPITHELIUM%GOBP%GO:0030277	maintenance of gastrointestinal epithelium	0.019389838569166675	0.019389838569166675	+1	SOX9,TLR4
REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%R-HSA-210744.2	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.019389838569166675	0.019389838569166675	+1	NOTCH1,EP300
NEGATIVE REGULATION OF JAK-STAT CASCADE%GOBP%GO:0046426	negative regulation of JAK-STAT cascade	0.019389838569166675	0.019389838569166675	+1	VHL,PPP2R1A
NEGATIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING%GOBP%GO:2000678	negative regulation of transcription regulatory region DNA binding	0.019389838569166675	0.019389838569166675	+1	TAF1,SIN3A
NEGATIVE REGULATION OF ANOIKIS%GOBP%GO:2000811	negative regulation of anoikis	0.019389838569166675	0.019389838569166675	+1	PIK3CA,NOTCH1
RESPONSE TO ACID CHEMICAL%GOBP%GO:0001101	response to acid chemical	0.019444988039378552	0.019444988039378552	+1	EPHA3,SOX9,ATM,MTOR,ASXL1
REGULATION OF CELL-SUBSTRATE ADHESION%GOBP%GO:0010810	regulation of cell-substrate adhesion	0.019444988039378552	0.019444988039378552	+1	PTEN,NF1,CDKN2A,NOTCH1,EPHA3
NEGATIVE REGULATION OF CELL MIGRATION%GOBP%GO:0030336	negative regulation of cell migration	0.019672360416647286	0.019672360416647286	+1	PTEN,NAV3,NF1,NOTCH1,CDH1,AKT1
RECOMBINATIONAL REPAIR%GOBP%GO:0000725	recombinational repair	0.01967814178777298	0.01967814178777298	+1	BRCA1,POLQ,BRCA2,RAD21
REGULATION OF MITOTIC METAPHASE/ANAPHASE TRANSITION%GOBP%GO:0030071	regulation of mitotic metaphase/anaphase transition	0.019705015724764872	0.019705015724764872	+1	APC,RB1,ATM
EPITHELIAL TUBE FORMATION%GOBP%GO:0072175	epithelial tube formation	0.019705015724764872	0.019705015724764872	+1	GATA3,SOX9,FGFR2
HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 73%3214842	HDMs demethylate histones	0.019705015724764872	0.019705015724764872	+1	KDM6A,KDM5C,ARID5B
CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN CELL-CELL SIGNALING%GOBP%GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	0.020044477275148416	0.020044477275148416	+1	PTEN,APC,GATA3,CTNNB1,AKT1,LRRK2
PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.1	Processing of DNA double-strand break ends	0.020334547306789783	0.020334547306789783	+1	ATM,BRCA1,ATR,HIST1H2BD
POSITIVE REGULATION OF WNT SIGNALING PATHWAY%GOBP%GO:0030177	positive regulation of Wnt signaling pathway	0.020419617278188633	0.020419617278188633	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 73%9646303	Evasion of Oncogene Induced Senescence Due to p14ARF Defects	0.020638738448568544	0.020638738448568544	+1	CDKN2A
BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY	BIOCARTA_PML_PATHWAY	0.020638738448568544	0.020638738448568544	+1	TP53,RB1
POSITIVE REGULATION OF MITOTIC RECOMBINATION%GOBP%GO:0045951	positive regulation of mitotic recombination	0.020638738448568544	0.020638738448568544	+1	ERCC2
MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.1	Masitinib-resistant KIT mutants	0.020638738448568544	0.020638738448568544	+1	KIT
MESENCHYMAL CELL DIFFERENTIATION INVOLVED IN LUNG DEVELOPMENT%GOBP%GO:0060915	mesenchymal cell differentiation involved in lung development	0.020638738448568544	0.020638738448568544	+1	FGFR2
ORBITOFRONTAL CORTEX DEVELOPMENT%GOBP%GO:0021769	orbitofrontal cortex development	0.020638738448568544	0.020638738448568544	+1	FGFR2
VENOUS ENDOTHELIAL CELL DIFFERENTIATION%GOBP%GO:0060843	venous endothelial cell differentiation	0.020638738448568544	0.020638738448568544	+1	NOTCH1
PEPTIDYL-LYSINE PROPIONYLATION%GOBP%GO:0061921	peptidyl-lysine propionylation	0.020638738448568544	0.020638738448568544	+1	EP300
FOREBRAIN ASTROCYTE DEVELOPMENT%GOBP%GO:0021897	forebrain astrocyte development	0.020638738448568544	0.020638738448568544	+1	NF1
PRIMARY SEX DETERMINATION, GERM-LINE%GOBP%GO:0007542	primary sex determination, germ-line	0.020638738448568544	0.020638738448568544	+1	SOX9
NEGATIVE REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN URETERIC BUD FORMATION%GOBP%GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.020638738448568544	0.020638738448568544	+1	GATA3
REGULATION OF MRNA STABILITY INVOLVED IN CELLULAR RESPONSE TO UV%GOBP%GO:1902629	regulation of mRNA stability involved in cellular response to UV	0.020638738448568544	0.020638738448568544	+1	NPM1
PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY	PID_NFKAPPAB_ATYPICAL_PATHWAY	0.020638738448568544	0.020638738448568544	+1	PIK3CA,PIK3R1
MALE GERM-LINE SEX DETERMINATION%GOBP%GO:0019100	male germ-line sex determination	0.020638738448568544	0.020638738448568544	+1	SOX9
APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 73%5467333	APC truncation mutants are not K63 polyubiquitinated	0.020638738448568544	0.020638738448568544	+1	APC
NEGATIVE REGULATION OF THIOREDOXIN PEROXIDASE ACTIVITY BY PEPTIDYL-THREONINE PHOSPHORYLATION%GOBP%GO:1903125	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation	0.020638738448568544	0.020638738448568544	+1	LRRK2
WNT SIGNALOSOME ASSEMBLY%GOBP%GO:1904887	Wnt signalosome assembly	0.020638738448568544	0.020638738448568544	+1	LRRK2
NEGATIVE REGULATION OF SYNAPTIC VESICLE CLUSTERING%GOBP%GO:2000808	negative regulation of synaptic vesicle clustering	0.020638738448568544	0.020638738448568544	+1	PTEN
BRANCHING INVOLVED IN LABYRINTHINE LAYER MORPHOGENESIS%GOBP%GO:0060670	branching involved in labyrinthine layer morphogenesis	0.020638738448568544	0.020638738448568544	+1	FGFR2
NEGATIVE REGULATION OF PEROXIDASE ACTIVITY%GOBP%GO:2000469	negative regulation of peroxidase activity	0.020638738448568544	0.020638738448568544	+1	LRRK2
CANONICAL WNT SIGNALING PATHWAY INVOLVED IN POSITIVE REGULATION OF CARDIAC OUTFLOW TRACT CELL PROLIFERATION%GOBP%GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	0.020638738448568544	0.020638738448568544	+1	CTNNB1
INFERIOR ENDOCARDIAL CUSHION MORPHOGENESIS%GOBP%GO:1905317	inferior endocardial cushion morphogenesis	0.020638738448568544	0.020638738448568544	+1	TGFBR2
REGULATION OF BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS BY MESENCHYMAL-EPITHELIAL SIGNALING%GOBP%GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	0.020638738448568544	0.020638738448568544	+1	HGF
VISCERAL SEROUS PERICARDIUM DEVELOPMENT%GOBP%GO:0061032	visceral serous pericardium development	0.020638738448568544	0.020638738448568544	+1	WT1
LUNG LOBE DEVELOPMENT%GOBP%GO:0060462	lung lobe development	0.020638738448568544	0.020638738448568544	+1	FGFR2
NILOTINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669926.1	Nilotinib-resistant KIT mutants	0.020638738448568544	0.020638738448568544	+1	KIT
NEGATIVE REGULATION OF CELL-SUBSTRATE ADHESION%GOBP%GO:0010812	negative regulation of cell-substrate adhesion	0.020638738448568544	0.020638738448568544	+1	PTEN,CDKN2A,NOTCH1
REGULATION OF GLIAL CELL-DERIVED NEUROTROPHIC FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN URETERIC BUD FORMATION%GOBP%GO:2000733	regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.020638738448568544	0.020638738448568544	+1	GATA3
DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 73%9661070	Defective translocation of RB1 mutants to the nucleus	0.020638738448568544	0.020638738448568544	+1	RB1
SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.1	Signaling by FGFR2 amplification mutants	0.020638738448568544	0.020638738448568544	+1	FGFR2
IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.1	Imatinib-resistant PDGFR mutants	0.020638738448568544	0.020638738448568544	+1	PDGFRA
REGULATION OF INVADOPODIUM DISASSEMBLY%GOBP%GO:1905927	regulation of invadopodium disassembly	0.020638738448568544	0.020638738448568544	+1	NAV3
DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.1	Drug resistance of KIT mutants	0.020638738448568544	0.020638738448568544	+1	KIT
NEGATIVE REGULATION OF HISTONE H3-K27 ACETYLATION%GOBP%GO:1901675	negative regulation of histone H3-K27 acetylation	0.020638738448568544	0.020638738448568544	+1	SIN3A
MAST CELL PROLIFERATION%GOBP%GO:0070662	mast cell proliferation	0.020638738448568544	0.020638738448568544	+1	KIT
SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9669933.1	Signaling by kinase domain mutants of KIT	0.020638738448568544	0.020638738448568544	+1	KIT
GROWTH PLATE CARTILAGE CHONDROCYTE GROWTH%GOBP%GO:0003430	growth plate cartilage chondrocyte growth	0.020638738448568544	0.020638738448568544	+1	SOX9
DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.1	Drug resistance of PDGFR mutants	0.020638738448568544	0.020638738448568544	+1	PDGFRA
NEGATIVE REGULATION OF PROTEIN KINASE ACTIVITY BY PROTEIN PHOSPHORYLATION%GOBP%GO:0100002	negative regulation of protein kinase activity by protein phosphorylation	0.020638738448568544	0.020638738448568544	+1	AKT1
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN POSITIVE REGULATION OF CELL PROLIFERATION IN BONE MARROW%GOBP%GO:0035604	fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	0.020638738448568544	0.020638738448568544	+1	FGFR2
CELL PROLIFERATION INVOLVED IN ENDOCARDIAL CUSHION MORPHOGENESIS%GOBP%GO:1905315	cell proliferation involved in endocardial cushion morphogenesis	0.020638738448568544	0.020638738448568544	+1	TGFBR2
CELL-CELL SIGNALING INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:0060995	cell-cell signaling involved in kidney development	0.020638738448568544	0.020638738448568544	+1	GATA3
GERM-LINE SEX DETERMINATION%GOBP%GO:0018992	germ-line sex determination	0.020638738448568544	0.020638738448568544	+1	SOX9
DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.1	Dasatinib-resistant KIT mutants	0.020638738448568544	0.020638738448568544	+1	KIT
NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER BY GLUCOSE%GOBP%GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	0.020638738448568544	0.020638738448568544	+1	FOXA2
POSITIVE REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS%GOBP%GO:2001022	positive regulation of response to DNA damage stimulus	0.020638738448568544	0.020638738448568544	+1	EGFR,ATM,BRCA1,ATR
CELL CYCLE DNA REPLICATION MAINTENANCE OF FIDELITY%GOBP%GO:1902298	cell cycle DNA replication maintenance of fidelity	0.020638738448568544	0.020638738448568544	+1	BRCA2
5-METHYLCYTOSINE METABOLIC PROCESS%GOBP%GO:0019857	5-methylcytosine metabolic process	0.020638738448568544	0.020638738448568544	+1	TET2
MORPHOGENESIS OF AN EPITHELIAL BUD%GOBP%GO:0060572	morphogenesis of an epithelial bud	0.020638738448568544	0.020638738448568544	+1	FGFR2
REGULATION OF METAPHASE/ANAPHASE TRANSITION OF CELL CYCLE%GOBP%GO:1902099	regulation of metaphase/anaphase transition of cell cycle	0.020638738448568544	0.020638738448568544	+1	APC,RB1,ATM
PEPTIDYL-LYSINE BUTYRYLATION%GOBP%GO:0140067	peptidyl-lysine butyrylation	0.020638738448568544	0.020638738448568544	+1	EP300
LUTEINIZING HORMONE SECRETION%GOBP%GO:0032275	luteinizing hormone secretion	0.020638738448568544	0.020638738448568544	+1	TBX3
REGULATION OF CARDIAC MYOFIBRIL ASSEMBLY%GOBP%GO:1905304	regulation of cardiac myofibril assembly	0.020638738448568544	0.020638738448568544	+1	SMAD4
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN ORBITOFRONTAL CORTEX DEVELOPMENT%GOBP%GO:0035607	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	0.020638738448568544	0.020638738448568544	+1	FGFR2
NEGATIVE REGULATION OF CELL PROLIFERATION INVOLVED IN MESONEPHROS DEVELOPMENT%GOBP%GO:2000607	negative regulation of cell proliferation involved in mesonephros development	0.020638738448568544	0.020638738448568544	+1	GATA3
POSITIVE REGULATION OF HISTONE H4-K20 METHYLATION%GOBP%GO:0070512	positive regulation of histone H4-K20 methylation	0.020638738448568544	0.020638738448568544	+1	BRCA1
CANONICAL WNT SIGNALING PATHWAY INVOLVED IN METANEPHRIC KIDNEY DEVELOPMENT%GOBP%GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	0.020638738448568544	0.020638738448568544	+1	GATA3
BRANCH ELONGATION INVOLVED IN SALIVARY GLAND MORPHOGENESIS%GOBP%GO:0060667	branch elongation involved in salivary gland morphogenesis	0.020638738448568544	0.020638738448568544	+1	FGFR2
REGULATION OF PROTEIN PROCESSING INVOLVED IN PROTEIN TARGETING TO MITOCHONDRION%GOBP%GO:1903216	regulation of protein processing involved in protein targeting to mitochondrion	0.020638738448568544	0.020638738448568544	+1	LRRK2
FOREBRAIN ASTROCYTE DIFFERENTIATION%GOBP%GO:0021896	forebrain astrocyte differentiation	0.020638738448568544	0.020638738448568544	+1	NF1
CELL-CELL SIGNALING INVOLVED IN METANEPHROS DEVELOPMENT%GOBP%GO:0072204	cell-cell signaling involved in metanephros development	0.020638738448568544	0.020638738448568544	+1	GATA3
CHONDROCYTE HYPERTROPHY%GOBP%GO:0003415	chondrocyte hypertrophy	0.020638738448568544	0.020638738448568544	+1	SOX9
NADPH REGENERATION%REACTOME DATABASE ID RELEASE 73%389542	NADPH regeneration	0.020638738448568544	0.020638738448568544	+1	IDH1
SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.1	Signaling by juxtamembrane domain KIT mutants	0.020638738448568544	0.020638738448568544	+1	KIT
IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.1	Imatinib-resistant KIT mutants	0.020638738448568544	0.020638738448568544	+1	KIT
REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.1	Regorafenib-resistant PDGFR mutants	0.020638738448568544	0.020638738448568544	+1	PDGFRA
POSITIVE REGULATION OF TRANSCRIPTION OF NOTCH RECEPTOR TARGET%GOBP%GO:0007221	positive regulation of transcription of Notch receptor target	0.020638738448568544	0.020638738448568544	+1	NOTCH1,EP300
NEGATIVE REGULATION OF PENTOSE-PHOSPHATE SHUNT%GOBP%GO:1905856	negative regulation of pentose-phosphate shunt	0.020638738448568544	0.020638738448568544	+1	TP53
PEPTIDYL-LYSINE CROTONYLATION%GOBP%GO:0140066	peptidyl-lysine crotonylation	0.020638738448568544	0.020638738448568544	+1	EP300
SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 73%9674401	Sunitinib-resistant PDGFR mutants	0.020638738448568544	0.020638738448568544	+1	PDGFRA
REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN DEFINITIVE ENDODERMAL CELL FATE SPECIFICATION%GOBP%GO:0060807	regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification	0.020638738448568544	0.020638738448568544	+1	SOX17
CHONDROCYTE DEVELOPMENT INVOLVED IN ENDOCHONDRAL BONE MORPHOGENESIS%GOBP%GO:0003433	chondrocyte development involved in endochondral bone morphogenesis	0.020638738448568544	0.020638738448568544	+1	SOX9
5-METHYLCYTOSINE CATABOLIC PROCESS%GOBP%GO:0006211	5-methylcytosine catabolic process	0.020638738448568544	0.020638738448568544	+1	TET2
SUNITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 73%9669934	Sunitinib-resistant KIT mutants	0.020638738448568544	0.020638738448568544	+1	KIT
CARDIOGENIC PLATE MORPHOGENESIS%GOBP%GO:0003142	cardiogenic plate morphogenesis	0.020638738448568544	0.020638738448568544	+1	SOX17
KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.1	KIT mutants bind TKIs	0.020638738448568544	0.020638738448568544	+1	KIT
PROSTATE EPITHELIAL CORD ELONGATION%GOBP%GO:0060523	prostate epithelial cord elongation	0.020638738448568544	0.020638738448568544	+1	FGFR2
EPITHELIAL CELL PROLIFERATION INVOLVED IN PROSTATE GLAND DEVELOPMENT%GOBP%GO:0060767	epithelial cell proliferation involved in prostate gland development	0.020638738448568544	0.020638738448568544	+1	SOX9
PLATELET-DERIVED GROWTH FACTOR RECEPTOR-ALPHA SIGNALING PATHWAY%GOBP%GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway	0.020638738448568544	0.020638738448568544	+1	PDGFRA
POSITIVE REGULATION OF NK T CELL DIFFERENTIATION%GOBP%GO:0051138	positive regulation of NK T cell differentiation	0.020638738448568544	0.020638738448568544	+1	TGFBR2
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.2	Transcriptional activation of mitochondrial biogenesis	0.020638738448568544	0.020638738448568544	+1	IDH2,TBL1XR1,NCOR1
PARAXIAL MESODERM MORPHOGENESIS%GOBP%GO:0048340	paraxial mesoderm morphogenesis	0.020638738448568544	0.020638738448568544	+1	SMAD2
REGULATION OF EIF2 ALPHA PHOSPHORYLATION BY DSRNA%GOBP%GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA	0.020638738448568544	0.020638738448568544	+1	NPM1
POSITIVE REGULATION OF TELOMERIC RNA TRANSCRIPTION FROM RNA POL II PROMOTER%GOBP%GO:1901582	positive regulation of telomeric RNA transcription from RNA pol II promoter	0.020638738448568544	0.020638738448568544	+1	ATRX
MORPHOGENESIS OF EMBRYONIC EPITHELIUM%GOBP%GO:0016331	morphogenesis of embryonic epithelium	0.020638738448568544	0.020638738448568544	+1	GATA3,SOX9,FGFR2
REGULATION OF THIOREDOXIN PEROXIDASE ACTIVITY%GOBP%GO:1903123	regulation of thioredoxin peroxidase activity	0.020638738448568544	0.020638738448568544	+1	LRRK2
SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.1	Sorafenib-resistant PDGFR mutants	0.020638738448568544	0.020638738448568544	+1	PDGFRA
REGULATION OF TELOMERIC RNA TRANSCRIPTION FROM RNA POL II PROMOTER%GOBP%GO:1901580	regulation of telomeric RNA transcription from RNA pol II promoter	0.020638738448568544	0.020638738448568544	+1	ATRX
MELANOCYTE ADHESION%GOBP%GO:0097326	melanocyte adhesion	0.020638738448568544	0.020638738448568544	+1	KIT
FOLLICLE-STIMULATING HORMONE SECRETION%GOBP%GO:0046884	follicle-stimulating hormone secretion	0.020638738448568544	0.020638738448568544	+1	TBX3
URETERIC BUD FORMATION%GOBP%GO:0060676	ureteric bud formation	0.020638738448568544	0.020638738448568544	+1	GATA3
NEGATIVE REGULATION OF TELOMERIC RNA TRANSCRIPTION FROM RNA POL II PROMOTER%GOBP%GO:1901581	negative regulation of telomeric RNA transcription from RNA pol II promoter	0.020638738448568544	0.020638738448568544	+1	ATRX
NEGATIVE REGULATION OF GLIAL CELL-DERIVED NEUROTROPHIC FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN URETERIC BUD FORMATION%GOBP%GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.020638738448568544	0.020638738448568544	+1	GATA3
SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 73%9680187	Signaling by extracellular domain mutants of KIT	0.020638738448568544	0.020638738448568544	+1	KIT
LUNG LOBE MORPHOGENESIS%GOBP%GO:0060463	lung lobe morphogenesis	0.020638738448568544	0.020638738448568544	+1	FGFR2
MITOTIC DNA REPLICATION MAINTENANCE OF FIDELITY%GOBP%GO:1990505	mitotic DNA replication maintenance of fidelity	0.020638738448568544	0.020638738448568544	+1	BRCA2
CARDIAC RIGHT ATRIUM MORPHOGENESIS%GOBP%GO:0003213	cardiac right atrium morphogenesis	0.020638738448568544	0.020638738448568544	+1	NOTCH1
REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO DNA DAMAGE%GOBP%GO:1990248	regulation of transcription from RNA polymerase II promoter in response to DNA damage	0.020638738448568544	0.020638738448568544	+1	TP53
LEPTIN INSULIN OVERLAP%WIKIPATHWAYS_20200810%WP3935%HOMO SAPIENS	Leptin Insulin Overlap	0.020638738448568544	0.020638738448568544	+1	AKT1,PIK3CG
NEGATIVE REGULATION OF TRANSCRIPTION BY GLUCOSE%GOBP%GO:0061986	negative regulation of transcription by glucose	0.020638738448568544	0.020638738448568544	+1	FOXA2
GROWTH PLATE CARTILAGE CHONDROCYTE DEVELOPMENT%GOBP%GO:0003431	growth plate cartilage chondrocyte development	0.020638738448568544	0.020638738448568544	+1	SOX9
INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 73%109606	Intrinsic Pathway for Apoptosis	0.020638738448568544	0.020638738448568544	+1	TP53,CDKN2A,AKT1
CANONICAL WNT SIGNALING PATHWAY INVOLVED IN NEGATIVE REGULATION OF APOPTOTIC PROCESS%GOBP%GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	0.020638738448568544	0.020638738448568544	+1	CTNNB1
NEGATIVE REGULATION OF METANEPHRIC GLOMERULUS DEVELOPMENT%GOBP%GO:0072299	negative regulation of metanephric glomerulus development	0.020638738448568544	0.020638738448568544	+1	WT1
NEGATIVE REGULATION OF PROTEIN PROCESSING INVOLVED IN PROTEIN TARGETING TO MITOCHONDRION%GOBP%GO:1903217	negative regulation of protein processing involved in protein targeting to mitochondrion	0.020638738448568544	0.020638738448568544	+1	LRRK2
PROSTATE EPITHELIAL CORD ARBORIZATION INVOLVED IN PROSTATE GLANDULAR ACINUS MORPHOGENESIS%GOBP%GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	0.020638738448568544	0.020638738448568544	+1	FGFR2
POSITIVE REGULATION OF INVADOPODIUM DISASSEMBLY%GOBP%GO:1905929	positive regulation of invadopodium disassembly	0.020638738448568544	0.020638738448568544	+1	NAV3
PDGFR MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 73%9674428	PDGFR mutants bind TKIs	0.020638738448568544	0.020638738448568544	+1	PDGFRA
MAMMARY GLAND BUD FORMATION%GOBP%GO:0060615	mammary gland bud formation	0.020638738448568544	0.020638738448568544	+1	FGFR2
MITOTIC RECOMBINATION-DEPENDENT REPLICATION FORK PROCESSING%GOBP%GO:1990426	mitotic recombination-dependent replication fork processing	0.020638738448568544	0.020638738448568544	+1	BRCA2
PRIMARY PROSTATIC BUD ELONGATION%GOBP%GO:0060516	primary prostatic bud elongation	0.020638738448568544	0.020638738448568544	+1	SOX9
REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.1	Regorafenib-resistant KIT mutants	0.020638738448568544	0.020638738448568544	+1	KIT
MESENCHYMAL-EPITHELIAL CELL SIGNALING%GOBP%GO:0060638	mesenchymal-epithelial cell signaling	0.020638738448568544	0.020638738448568544	+1	HGF
REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 73%912631	Regulation of signaling by CBL	0.020638738448568544	0.020638738448568544	+1	PIK3CA,PIK3R1
REGULATION OF MOLECULAR FUNCTION, EPIGENETIC%GOBP%GO:0040030	regulation of molecular function, epigenetic	0.020638738448568544	0.020638738448568544	+1	CTCF
NEGATIVE REGULATION OF STAT CASCADE%GOBP%GO:1904893	negative regulation of STAT cascade	0.020638738448568544	0.020638738448568544	+1	VHL,PPP2R1A
MESENCHYMAL CELL PROLIFERATION INVOLVED IN LUNG DEVELOPMENT%GOBP%GO:0060916	mesenchymal cell proliferation involved in lung development	0.020638738448568544	0.020638738448568544	+1	FGFR2
EPITHELIAL CELL PROLIFERATION INVOLVED IN PROSTATIC BUD ELONGATION%GOBP%GO:0060517	epithelial cell proliferation involved in prostatic bud elongation	0.020638738448568544	0.020638738448568544	+1	SOX9
REGULATION OF CELL PROLIFERATION INVOLVED IN TISSUE HOMEOSTASIS%GOBP%GO:0060784	regulation of cell proliferation involved in tissue homeostasis	0.020638738448568544	0.020638738448568544	+1	SOX9
T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME DATABASE ID RELEASE 73%2033515	t(4;14) translocations of FGFR3	0.020638738448568544	0.020638738448568544	+1	FGFR3
NEGATIVE REGULATION OF EPITHELIAL TUBE FORMATION%GOBP%GO:1905277	negative regulation of epithelial tube formation	0.020638738448568544	0.020638738448568544	+1	GATA3
SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 73%8853333	Signaling by FGFR2 fusions	0.020638738448568544	0.020638738448568544	+1	FGFR2
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN NEGATIVE REGULATION OF APOPTOTIC PROCESS IN BONE MARROW%GOBP%GO:0035602	fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow	0.020638738448568544	0.020638738448568544	+1	FGFR2
PROSTATE GLANDULAR ACINUS MORPHOGENESIS%GOBP%GO:0060526	prostate glandular acinus morphogenesis	0.020638738448568544	0.020638738448568544	+1	FGFR2
NEGATIVE REGULATION OF THIOREDOXIN PEROXIDASE ACTIVITY%GOBP%GO:1903124	negative regulation of thioredoxin peroxidase activity	0.020638738448568544	0.020638738448568544	+1	LRRK2
SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.1	Sorafenib-resistant KIT mutants	0.020638738448568544	0.020638738448568544	+1	KIT
REGULATION OF TOLERANCE INDUCTION TO SELF ANTIGEN%GOBP%GO:0002649	regulation of tolerance induction to self antigen	0.020638738448568544	0.020638738448568544	+1	TGFBR2
NEGATIVE REGULATION OF RNA-DIRECTED 5'-3' RNA POLYMERASE ACTIVITY%GOBP%GO:1900260	negative regulation of RNA-directed 5'-3' RNA polymerase activity	0.020638738448568544	0.020638738448568544	+1	EIF4A2
PARAXIAL MESODERM DEVELOPMENT%GOBP%GO:0048339	paraxial mesoderm development	0.020638738448568544	0.020638738448568544	+1	SMAD2
REGULATION OF TRANSCRIPTION INVOLVED IN PRIMARY GERM LAYER CELL FATE COMMITMENT%GOBP%GO:0060796	regulation of transcription involved in primary germ layer cell fate commitment	0.020638738448568544	0.020638738448568544	+1	SOX17
SQUAMOUS BASAL EPITHELIAL STEM CELL DIFFERENTIATION INVOLVED IN PROSTATE GLAND ACINUS DEVELOPMENT%GOBP%GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	0.020638738448568544	0.020638738448568544	+1	FGFR2
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN HEMOPOIESIS%GOBP%GO:0035603	fibroblast growth factor receptor signaling pathway involved in hemopoiesis	0.020638738448568544	0.020638738448568544	+1	FGFR2
NEGATIVE REGULATION OF DETECTION OF GLUCOSE%GOBP%GO:2000971	negative regulation of detection of glucose	0.020638738448568544	0.020638738448568544	+1	FOXA2
NEGATIVE REGULATION OF KERATINOCYTE MIGRATION%GOBP%GO:0051548	negative regulation of keratinocyte migration	0.020638738448568544	0.020638738448568544	+1	PTEN
REGULATION OF DETECTION OF GLUCOSE%GOBP%GO:2000970	regulation of detection of glucose	0.020638738448568544	0.020638738448568544	+1	FOXA2
SIGNAL TRANSDUCTION INVOLVED IN INTRA-S DNA DAMAGE CHECKPOINT%GOBP%GO:0072428	signal transduction involved in intra-S DNA damage checkpoint	0.020638738448568544	0.020638738448568544	+1	CHEK2
POSITIVE REGULATION OF CELL PROLIFERATION INVOLVED IN HEART VALVE MORPHOGENESIS%GOBP%GO:0003251	positive regulation of cell proliferation involved in heart valve morphogenesis	0.020638738448568544	0.020638738448568544	+1	SMAD4
MAMMARY GLAND BUD MORPHOGENESIS%GOBP%GO:0060648	mammary gland bud morphogenesis	0.020638738448568544	0.020638738448568544	+1	FGFR2
POSITIVE REGULATION OF TOLERANCE INDUCTION TO SELF ANTIGEN%GOBP%GO:0002651	positive regulation of tolerance induction to self antigen	0.020638738448568544	0.020638738448568544	+1	TGFBR2
EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 73%9646304	Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	0.020638738448568544	0.020638738448568544	+1	CDKN2A
REGULATION OF RNA-DIRECTED 5'-3' RNA POLYMERASE ACTIVITY%GOBP%GO:1900259	regulation of RNA-directed 5'-3' RNA polymerase activity	0.020638738448568544	0.020638738448568544	+1	EIF4A2
FIBROBLAST GROWTH FACTOR RECEPTOR APOPTOTIC SIGNALING PATHWAY%GOBP%GO:1902178	fibroblast growth factor receptor apoptotic signaling pathway	0.020638738448568544	0.020638738448568544	+1	FGFR3
SUPERIOR ENDOCARDIAL CUSHION MORPHOGENESIS%GOBP%GO:1905316	superior endocardial cushion morphogenesis	0.020638738448568544	0.020638738448568544	+1	TGFBR2
NEGATIVE REGULATION OF CARDIAC MYOFIBRIL ASSEMBLY%GOBP%GO:1905305	negative regulation of cardiac myofibril assembly	0.020638738448568544	0.020638738448568544	+1	SMAD4
PTEN LOSS OF FUNCTION IN CANCER%REACTOME DATABASE ID RELEASE 73%5674404	PTEN Loss of Function in Cancer	0.020638738448568544	0.020638738448568544	+1	PTEN
SIGNAL TRANSDUCTION INVOLVED IN MITOTIC G2 DNA DAMAGE CHECKPOINT%GOBP%GO:0072434	signal transduction involved in mitotic G2 DNA damage checkpoint	0.020638738448568544	0.020638738448568544	+1	ATM
REGULATION OF CELL PROLIFERATION INVOLVED IN MESONEPHROS DEVELOPMENT%GOBP%GO:2000606	regulation of cell proliferation involved in mesonephros development	0.020638738448568544	0.020638738448568544	+1	GATA3
BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS%GOBP%GO:0060445	branching involved in salivary gland morphogenesis	0.020638738448568544	0.020638738448568544	+1	FGFR2
BUD ELONGATION INVOLVED IN LUNG BRANCHING%GOBP%GO:0060449	bud elongation involved in lung branching	0.020638738448568544	0.020638738448568544	+1	FGFR2
POSITIVE REGULATION OF MACROPHAGE ACTIVATION%GOBP%GO:0043032	positive regulation of macrophage activation	0.020638738448568544	0.020638738448568544	+1	CEBPA,TLR4
REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN URETERIC BUD FORMATION%GOBP%GO:2000702	regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.020638738448568544	0.020638738448568544	+1	GATA3
ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME%R-HSA-2978092.1	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	0.020638738448568544	0.020638738448568544	+1	IDH1
WNT SIGNALING PATHWAY INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:0061289	Wnt signaling pathway involved in kidney development	0.020638738448568544	0.020638738448568544	+1	GATA3
TREHALOSE METABOLISM IN RESPONSE TO STRESS%GOBP%GO:0070413	trehalose metabolism in response to stress	0.020638738448568544	0.020638738448568544	+1	BRAF
NEGATIVE REGULATION OF METANEPHRIC GLOMERULAR MESANGIAL CELL PROLIFERATION%GOBP%GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation	0.020638738448568544	0.020638738448568544	+1	WT1
HALLMARK_ANDROGEN_RESPONSE%MSIGDB_C2%HALLMARK_ANDROGEN_RESPONSE	HALLMARK_ANDROGEN_RESPONSE	0.020640932989279222	0.020640932989279222	+1	AKT1,ARID5B,CCND1,LIFR
PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY	PID_CD8_TCR_PATHWAY	0.02105179250766914	0.02105179250766914	+1	KRAS,NRAS,AKT1
TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS	TCR signaling in naive CD8+ T cells	0.02105179250766914	0.02105179250766914	+1	KRAS,NRAS,AKT1
B CELL ACTIVATION%PANTHER PATHWAY%P00010	B cell activation	0.02105179250766914	0.02105179250766914	+1	PIK3CA,NRAS,PIK3CG
INNER EAR DEVELOPMENT%GOBP%GO:0048839	inner ear development	0.02105179250766914	0.02105179250766914	+1	SOX9,FGFR2,PTPN11
NEGATIVE REGULATION OF CHROMATIN ORGANIZATION%GOBP%GO:1905268	negative regulation of chromatin organization	0.02105179250766914	0.02105179250766914	+1	BRCA1,HIST1H1C,SIN3A
NEGATIVE REGULATION OF PROTEIN COMPLEX DISASSEMBLY%GOBP%GO:0043242	negative regulation of protein complex disassembly	0.02105179250766914	0.02105179250766914	+1	PIK3CA,APC,NAV3
ENDOTHELIAL CELL MIGRATION%GOBP%GO:0043542	endothelial cell migration	0.02105179250766914	0.02105179250766914	+1	PIK3CA,AKT1,EGR3
NEPHRON EPITHELIUM DEVELOPMENT%GOBP%GO:0072009	nephron epithelium development	0.02105179250766914	0.02105179250766914	+1	GATA3,SOX9,WT1
GLIOGENESIS%GOBP%GO:0042063	gliogenesis	0.021253251976739856	0.021253251976739856	+1	PTEN,NF1,SOX9,PRX
HALLMARK_TGF_BETA_SIGNALING%MSIGDB_C2%HALLMARK_TGF_BETA_SIGNALING	HALLMARK_TGF_BETA_SIGNALING	0.021856639002269647	0.021856639002269647	+1	APC,CTNNB1,CDH1
SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 73%1250196	SHC1 events in ERBB2 signaling	0.021856639002269647	0.021856639002269647	+1	EGFR,NRAS
BRAIN MORPHOGENESIS%GOBP%GO:0048854	brain morphogenesis	0.021856639002269647	0.021856639002269647	+1	PTEN,NF1
NEGATIVE REGULATION OF PROTEIN ACETYLATION%GOBP%GO:1901984	negative regulation of protein acetylation	0.021856639002269647	0.021856639002269647	+1	BRCA1,SIN3A
REGULATION OF OLIGODENDROCYTE DIFFERENTIATION%GOBP%GO:0048713	regulation of oligodendrocyte differentiation	0.021856639002269647	0.021856639002269647	+1	NF1,NOTCH1
CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS%GOBP%GO:0002042	cell migration involved in sprouting angiogenesis	0.021856639002269647	0.021856639002269647	+1	AKT1,EGR3
NEGATIVE REGULATION OF FIBROBLAST PROLIFERATION%GOBP%GO:0048147	negative regulation of fibroblast proliferation	0.021856639002269647	0.021856639002269647	+1	TP53,NF1
4-HYDROXYTAMOXIFEN, DEXAMETHASONE, AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20200810%WP3879%HOMO SAPIENS	4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression	0.021856639002269647	0.021856639002269647	+1	AKT1,MTOR
SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 73%9665686	Signaling by ERBB2 TMD JMD mutants	0.021856639002269647	0.021856639002269647	+1	EGFR,NRAS
VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS	Validated transcriptional targets of TAp63 isoforms	0.021856639002269647	0.021856639002269647	+1	CDKN2A,EP300,CDKN1A
PROTEIN LOCALIZATION TO CHROMOSOME, CENTROMERIC REGION%GOBP%GO:0071459	protein localization to chromosome, centromeric region	0.021856639002269647	0.021856639002269647	+1	RB1,CTCF
METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 73%8978934	Metabolism of cofactors	0.021856639002269647	0.021856639002269647	+1	IDH1,AKT1
FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.3	FRS-mediated FGFR4 signaling	0.021856639002269647	0.021856639002269647	+1	NRAS,PTPN11
REGULATION OF CD4-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	0.021856639002269647	0.021856639002269647	+1	RUNX1,TGFBR2,CBFB
APOPTOSIS-RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20200810%WP2864%HOMO SAPIENS	Apoptosis-related network due to altered Notch3 in ovarian cancer	0.021856639002269647	0.021856639002269647	+1	AKT1,CDKN1B,CDKN1A
ENDOCHONDRAL BONE MORPHOGENESIS%GOBP%GO:0060350	endochondral bone morphogenesis	0.021856639002269647	0.021856639002269647	+1	SOX9,FGFR3
NOTCH1 REGULATION OF HUMAN ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20200810%WP3413%HOMO SAPIENS	NOTCH1 regulation of human endothelial cell calcification	0.021856639002269647	0.021856639002269647	+1	NOTCH1,FGFR3
PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY	PID_TAP63_PATHWAY	0.021856639002269647	0.021856639002269647	+1	CDKN2A,EP300,CDKN1A
REGULATION OF MITOTIC SISTER CHROMATID SEPARATION%GOBP%GO:0010965	regulation of mitotic sister chromatid separation	0.021856639002269647	0.021856639002269647	+1	APC,RB1,ATM
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.2	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.021856639002269647	0.021856639002269647	+1	TP53,EP300
TRANSCRIPTION CO-FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20200810%WP4533%HOMO SAPIENS	Transcription co-factors SKI and SKIL protein partners	0.021856639002269647	0.021856639002269647	+1	NF1,SIN3A
SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 73%3232118	SUMOylation of transcription factors	0.021856639002269647	0.021856639002269647	+1	TP53,CDKN2A
REGULATION OF WNT/B-CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20200810%WP3664%HOMO SAPIENS	Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds	0.021856639002269647	0.021856639002269647	+1	APC,CTNNB1
RORA ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-1368082.3	RORA activates gene expression	0.021856639002269647	0.021856639002269647	+1	EP300,TBL1XR1
NEGATIVE REGULATION OF GLIOGENESIS%GOBP%GO:0014014	negative regulation of gliogenesis	0.021856639002269647	0.021856639002269647	+1	NF1,NOTCH1
NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY%GOBP%GO:0090090	negative regulation of canonical Wnt signaling pathway	0.021956004564833688	0.021956004564833688	+1	APC,STK11,SOX9,SOX17,AXIN2
SUDDEN INFANT DEATH SYNDROME (SIDS) SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20200810%WP706%HOMO SAPIENS	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	0.021956004564833688	0.021956004564833688	+1	GATA3,CTNNB1,CTCF,AR,EP300
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 73%8941858	Regulation of RUNX3 expression and activity	0.022891081379142846	0.022891081379142846	+1	CDKN2A,EP300,CBFB
PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20200810%WP2272%HOMO SAPIENS	Pathogenic Escherichia coli infection	0.022891081379142846	0.022891081379142846	+1	CTNNB1,CDH1,TLR4
THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING	Thromboxane A2 receptor signaling	0.022891081379142846	0.022891081379142846	+1	EGFR,AKT1,PIK3CG
LEUKOCYTE PROLIFERATION%GOBP%GO:0070661	leukocyte proliferation	0.022891081379142846	0.022891081379142846	+1	FLT3,PIK3CG,KIT
REGULATION OF CENTROSOME CYCLE%GOBP%GO:0046605	regulation of centrosome cycle	0.022891081379142846	0.022891081379142846	+1	CTNNB1,NPM1,BRCA1
RANKL/RANK (RECEPTOR ACTIVATOR OF NFKB (LIGAND)) SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP2018%HOMO SAPIENS	RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway	0.022891081379142846	0.022891081379142846	+1	PIK3R1,AKT1,MTOR
POSITIVE REGULATION OF PROTEIN UBIQUITINATION%GOBP%GO:0031398	positive regulation of protein ubiquitination	0.023051420421378237	0.023051420421378237	+1	PTEN,FBXW7,BRCA1,LRRK2
REGULATION OF T CELL DIFFERENTIATION%GOBP%GO:0045580	regulation of T cell differentiation	0.023051420421378237	0.023051420421378237	+1	GATA3,RUNX1,TGFBR2,CBFB
DNA RECOMBINATION%GOBP%GO:0006310	DNA recombination	0.023547217265215917	0.023547217265215917	+1	ATM,BRCA1,POLQ,BRCA2,RAD21
POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION%GOBP%GO:1902107	positive regulation of leukocyte differentiation	0.02377758425141173	0.02377758425141173	+1	GATA3,RUNX1,TGFBR2,CBFB
PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS%GOBP%GO:0006661	phosphatidylinositol biosynthetic process	0.02377758425141173	0.02377758425141173	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
RAS PROCESSING%REACTOME DATABASE ID RELEASE 73%9648002	RAS processing	0.023815363688671216	0.023815363688671216	+1	KRAS,NRAS
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.1	Listeria monocytogenes entry into host cells	0.023815363688671216	0.023815363688671216	+1	CTNNB1,CDH1
BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY	BIOCARTA_TOB1_PATHWAY	0.023815363688671216	0.023815363688671216	+1	SMAD4,TGFBR2
NEGATIVE REGULATION OF OXIDATIVE STRESS-INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.023815363688671216	0.023815363688671216	+1	NFE2L2,AKT1
REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY%GOBP%GO:2000810	regulation of bicellular tight junction assembly	0.023815363688671216	0.023815363688671216	+1	RUNX1,CBFB
REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-HSA-210745.1	Regulation of gene expression in beta cells	0.023815363688671216	0.023815363688671216	+1	AKT1,FOXA2
EPITHELIAL STRUCTURE MAINTENANCE%GOBP%GO:0010669	epithelial structure maintenance	0.023815363688671216	0.023815363688671216	+1	SOX9,TLR4
INTRACELLULAR ESTROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0030520	intracellular estrogen receptor signaling pathway	0.023815363688671216	0.023815363688671216	+1	ARID1A,AR
CELL FATE DETERMINATION%GOBP%GO:0001709	cell fate determination	0.023815363688671216	0.023815363688671216	+1	GATA3,SOX17
MITOTIC SPINDLE ASSEMBLY CHECKPOINT%GOBP%GO:0007094	mitotic spindle assembly checkpoint	0.023815363688671216	0.023815363688671216	+1	APC,ATM
FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 73%5654700	FRS-mediated FGFR2 signaling	0.023815363688671216	0.023815363688671216	+1	NRAS,PTPN11
NEGATIVE REGULATION OF NUCLEOTIDE METABOLIC PROCESS%GOBP%GO:0045980	negative regulation of nucleotide metabolic process	0.023815363688671216	0.023815363688671216	+1	TP53,NCOR1
MYELINATION%GOBP%GO:0042552	myelination	0.023815363688671216	0.023815363688671216	+1	PTEN,NF1,PRX
HAIR CELL DIFFERENTIATION%GOBP%GO:0035315	hair cell differentiation	0.023815363688671216	0.023815363688671216	+1	CTNNB1,ERCC2
REGULATION OF OXIDATIVE STRESS-INDUCED NEURON DEATH%GOBP%GO:1903203	regulation of oxidative stress-induced neuron death	0.023815363688671216	0.023815363688671216	+1	FBXW7,TLR4
CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT%GOBP%GO:0061311	cell surface receptor signaling pathway involved in heart development	0.023815363688671216	0.023815363688671216	+1	NOTCH1,CTNNB1
SPINDLE CHECKPOINT%GOBP%GO:0031577	spindle checkpoint	0.023815363688671216	0.023815363688671216	+1	APC,ATM
SPINDLE ASSEMBLY CHECKPOINT%GOBP%GO:0071173	spindle assembly checkpoint	0.023815363688671216	0.023815363688671216	+1	APC,ATM
HAIR FOLLICLE DEVELOPMENT%GOBP%GO:0001942	hair follicle development	0.023815363688671216	0.023815363688671216	+1	SOX9,FGFR2
CCR9%IOB%CCR9	CCR9	0.023815363688671216	0.023815363688671216	+1	CDH1,AKT1
EXCITATORY POSTSYNAPTIC POTENTIAL%GOBP%GO:0060079	excitatory postsynaptic potential	0.023815363688671216	0.023815363688671216	+1	AKT1,LRRK2
RESPONSE TO CHOLESTEROL%GOBP%GO:0070723	response to cholesterol	0.023815363688671216	0.023815363688671216	+1	TGFBR2,SMAD2
MITOTIC SPINDLE CHECKPOINT%GOBP%GO:0071174	mitotic spindle checkpoint	0.023815363688671216	0.023815363688671216	+1	APC,ATM
RESPONSE TO FLUID SHEAR STRESS%GOBP%GO:0034405	response to fluid shear stress	0.023815363688671216	0.023815363688671216	+1	NFE2L2,AKT1
NUCLEOTIDE-EXCISION REPAIR%GOBP%GO:0006289	nucleotide-excision repair	0.024233397094109523	0.024233397094109523	+1	TP53,EP300,BRCA2,ERCC2
PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY	PID_TXA2PATHWAY	0.024797129651664206	0.024797129651664206	+1	EGFR,AKT1,PIK3CG
GLIAL CELL DEVELOPMENT%GOBP%GO:0021782	glial cell development	0.024797129651664206	0.024797129651664206	+1	PTEN,NF1,PRX
POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION%GOBP%GO:1903749	positive regulation of establishment of protein localization to mitochondrion	0.024797129651664206	0.024797129651664206	+1	TP53,FBXW7,BAP1
RESPIRATORY SYSTEM DEVELOPMENT%GOBP%GO:0060541	respiratory system development	0.024797129651664206	0.024797129651664206	+1	CEBPA,WT1,FGFR2
THERMOGENESIS%WIKIPATHWAYS_20200810%WP4321%HOMO SAPIENS	Thermogenesis	0.024939938482704472	0.024939938482704472	+1	KRAS,ARID1A,NRAS,MTOR
CELLULAR RESPONSE TO PEPTIDE%GOBP%GO:1901653	cellular response to peptide	0.024939938482704472	0.024939938482704472	+1	TP53,PIK3CA,APC,PIK3R1,AKT1,TLR4
SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 73%2467813	Separation of Sister Chromatids	0.02547188916017742	0.02547188916017742	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
RNA LOCALIZATION%GOBP%GO:0006403	RNA localization	0.02547188916017742	0.02547188916017742	+1	NPM1,ATM,U2AF1,TGFBR2,ATR
DNA METHYLATION OR DEMETHYLATION%GOBP%GO:0044728	DNA methylation or demethylation	0.025909653369359166	0.025909653369359166	+1	DNMT3A,TET2,ATRX
AXON ENSHEATHMENT%GOBP%GO:0008366	axon ensheathment	0.025909653369359166	0.025909653369359166	+1	PTEN,NF1,PRX
ENSHEATHMENT OF NEURONS%GOBP%GO:0007272	ensheathment of neurons	0.025909653369359166	0.025909653369359166	+1	PTEN,NF1,PRX
CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS%GOBP%GO:0021955	central nervous system neuron axonogenesis	0.025919071062512372	0.025919071062512372	+1	PTEN,ARHGAP35
BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY	BIOCARTA_NKCELLS_PATHWAY	0.025919071062512372	0.025919071062512372	+1	PIK3CA,PIK3R1
EMBRYONIC DIGESTIVE TRACT DEVELOPMENT%GOBP%GO:0048566	embryonic digestive tract development	0.025919071062512372	0.025919071062512372	+1	PDGFRA,FGFR2
MITOTIC G2 DNA DAMAGE CHECKPOINT%GOBP%GO:0007095	mitotic G2 DNA damage checkpoint	0.025919071062512372	0.025919071062512372	+1	ATM,CDKN1A
PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY	PID_WNT_CANONICAL_PATHWAY	0.025919071062512372	0.025919071062512372	+1	APC,CTNNB1
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 73%2730905	Role of LAT2 NTAL LAB on calcium mobilization	0.025919071062512372	0.025919071062512372	+1	PIK3CA,PIK3R1
NEGATIVE REGULATION OF MITOTIC METAPHASE/ANAPHASE TRANSITION%GOBP%GO:0045841	negative regulation of mitotic metaphase/anaphase transition	0.025919071062512372	0.025919071062512372	+1	APC,ATM
NEGATIVE REGULATION OF ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0046639	negative regulation of alpha-beta T cell differentiation	0.025919071062512372	0.025919071062512372	+1	RUNX1,CBFB
REGULATION OF NUCLEASE ACTIVITY%GOBP%GO:0032069	regulation of nuclease activity	0.025919071062512372	0.025919071062512372	+1	NPM1,AKT1
NEGATIVE REGULATION OF MICROTUBULE DEPOLYMERIZATION%GOBP%GO:0007026	negative regulation of microtubule depolymerization	0.025919071062512372	0.025919071062512372	+1	APC,NAV3
SEROTONIN RECEPTOR 2 AND ELK-SRF/GATA4 SIGNALING%WIKIPATHWAYS_20200810%WP732%HOMO SAPIENS	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling	0.025919071062512372	0.025919071062512372	+1	KRAS,NRAS
POSITIVE REGULATION OF INTERFERON-ALPHA PRODUCTION%GOBP%GO:0032727	positive regulation of interferon-alpha production	0.025919071062512372	0.025919071062512372	+1	TLR4,SETD2
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 73%9013695	NOTCH4 Intracellular Domain Regulates Transcription	0.025919071062512372	0.025919071062512372	+1	NOTCH1,EP300
NEGATIVE REGULATION OF OSTEOCLAST DIFFERENTIATION%GOBP%GO:0045671	negative regulation of osteoclast differentiation	0.025919071062512372	0.025919071062512372	+1	FBXW7,TLR4
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.1	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.025919071062512372	0.025919071062512372	+1	TP53,ATM
CD209 (DC-SIGN) SIGNALING%REACTOME%R-HSA-5621575.1	CD209 (DC-SIGN) signaling	0.025919071062512372	0.025919071062512372	+1	NRAS,EP300
HETEROCHROMATIN ORGANIZATION%GOBP%GO:0070828	heterochromatin organization	0.025919071062512372	0.025919071062512372	+1	CDKN2A,MECOM
CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY	Canonical Wnt signaling pathway	0.025919071062512372	0.025919071062512372	+1	APC,CTNNB1
ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004	Alzheimer disease-presenilin pathway	0.026210617451157606	0.026210617451157606	+1	NOTCH1,CTNNB1,CDH1,ERBB4
RESPONSE TO REACTIVE OXYGEN SPECIES%GOBP%GO:0000302	response to reactive oxygen species	0.026210617451157606	0.026210617451157606	+1	EGFR,NFE2L2,AKT1,PDGFRA
REGULATION OF PROTEIN ACETYLATION%GOBP%GO:1901983	regulation of protein acetylation	0.02683729048223162	0.02683729048223162	+1	BRCA1,SMAD4,SIN3A
REGULATION OF CHROMOSOME SEPARATION%GOBP%GO:1905818	regulation of chromosome separation	0.02683729048223162	0.02683729048223162	+1	APC,RB1,ATM
NUCLEOSOME ASSEMBLY%GOBP%GO:0006334	nucleosome assembly	0.026990143098468908	0.026990143098468908	+1	NPM1,SOX9,ATRX,HIST1H2BD
HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20200810%WP2849%HOMO SAPIENS	Hematopoietic Stem Cell Differentiation	0.02802104318065723	0.02802104318065723	+1	NOTCH1,RUNX1,ACVR1B
REGULATION OF ADHERENS JUNCTION ORGANIZATION%GOBP%GO:1903391	regulation of adherens junction organization	0.02802104318065723	0.02802104318065723	+1	PTEN,PIK3R1,EPHA3
SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.3	SCF(Skp2)-mediated degradation of p27 p21	0.02802104318065723	0.02802104318065723	+1	CDKN1B,CCND1,CDKN1A
PREIMPLANTATION EMBRYO%WIKIPATHWAYS_20200810%WP3527%HOMO SAPIENS	Preimplantation Embryo	0.02802104318065723	0.02802104318065723	+1	GATA3,CDH1,TBX3
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.1	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.028138966004679678	0.028138966004679678	+1	TP53,NPM1
URETERIC BUD MORPHOGENESIS%GOBP%GO:0060675	ureteric bud morphogenesis	0.028138966004679678	0.028138966004679678	+1	GATA3,WT1
HAIR CYCLE PROCESS%GOBP%GO:0022405	hair cycle process	0.028138966004679678	0.028138966004679678	+1	SOX9,FGFR2
INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE BY P53 CLASS MEDIATOR%GOBP%GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	0.028138966004679678	0.028138966004679678	+1	TP53,EP300
SKIN EPIDERMIS DEVELOPMENT%GOBP%GO:0098773	skin epidermis development	0.028138966004679678	0.028138966004679678	+1	SOX9,FGFR2
REGULATION OF SMOOTH MUSCLE CELL DIFFERENTIATION%GOBP%GO:0051150	regulation of smooth muscle cell differentiation	0.028138966004679678	0.028138966004679678	+1	KIT,FGFR2
POSITIVE REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:1901798	positive regulation of signal transduction by p53 class mediator	0.028138966004679678	0.028138966004679678	+1	ATM,ATR
NGF%IOB%NGF	NGF	0.028138966004679678	0.028138966004679678	+1	BRAF,PTPN11
REGULATION OF UBIQUITIN PROTEIN LIGASE ACTIVITY%GOBP%GO:1904666	regulation of ubiquitin protein ligase activity	0.028138966004679678	0.028138966004679678	+1	PTEN,RPL5
CELL CHEMOTAXIS%GOBP%GO:0060326	cell chemotaxis	0.028138966004679678	0.028138966004679678	+1	PIK3CG,HGF,KIT,PDGFRA,EGR3
NEGATIVE REGULATION OF METAPHASE/ANAPHASE TRANSITION OF CELL CYCLE%GOBP%GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	0.028138966004679678	0.028138966004679678	+1	APC,ATM
MOLTING CYCLE PROCESS%GOBP%GO:0022404	molting cycle process	0.028138966004679678	0.028138966004679678	+1	SOX9,FGFR2
SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS	Syndecan-3-mediated signaling events	0.028138966004679678	0.028138966004679678	+1	EGFR,FGFR3
FOREBRAIN NEURON DIFFERENTIATION%GOBP%GO:0021879	forebrain neuron differentiation	0.028138966004679678	0.028138966004679678	+1	ERBB4,FGFR2
REGULATION OF ANOIKIS%GOBP%GO:2000209	regulation of anoikis	0.028138966004679678	0.028138966004679678	+1	PIK3CA,NOTCH1
BETA-CATENIN DESTRUCTION COMPLEX DISASSEMBLY%GOBP%GO:1904886	beta-catenin destruction complex disassembly	0.028138966004679678	0.028138966004679678	+1	APC,CTNNB1
RESPONSE TO NUTRIENT LEVELS%GOBP%GO:0031667	response to nutrient levels	0.028341025444377502	0.028341025444377502	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
ACTIVATION OF INNATE IMMUNE RESPONSE%GOBP%GO:0002218	activation of innate immune response	0.028341025444377502	0.028341025444377502	+1	KRAS,MAP3K1,NRAS,TLR4,EP300,SIN3A
REGULATION OF GENE SILENCING BY MIRNA%GOBP%GO:0060964	regulation of gene silencing by miRNA	0.028342551001956436	0.028342551001956436	+1	TP53,EGFR,AJUBA,NCOR1
MIDBRAIN DEVELOPMENT%GOBP%GO:0030901	midbrain development	0.028948525893947228	0.028948525893947228	+1	CTNNB1,FGFR2,TAF1
RESPONSE TO NUTRIENT%GOBP%GO:0007584	response to nutrient	0.028948525893947228	0.028948525893947228	+1	MTOR,FOXA2,TAF1
NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 73%198725	Nuclear Events (kinase and transcription factor activation)	0.028948525893947228	0.028948525893947228	+1	EP300,PPP2R1A,EGR3
REGULATION OF PROTEIN DEPOLYMERIZATION%GOBP%GO:1901879	regulation of protein depolymerization	0.028948525893947228	0.028948525893947228	+1	PIK3CA,APC,NAV3
ENDOTHELIAL CELL DIFFERENTIATION%GOBP%GO:0045446	endothelial cell differentiation	0.028948525893947228	0.028948525893947228	+1	NOTCH1,SMAD4,SOX17
REGULATION OF GENE SILENCING BY RNA%GOBP%GO:0060966	regulation of gene silencing by RNA	0.02908322115048775	0.02908322115048775	+1	TP53,EGFR,AJUBA,NCOR1
CELLULAR RESPONSE TO ACID CHEMICAL%GOBP%GO:0071229	cellular response to acid chemical	0.02908322115048775	0.02908322115048775	+1	EPHA3,SOX9,ATM,MTOR
REGULATION OF POSTTRANSCRIPTIONAL GENE SILENCING%GOBP%GO:0060147	regulation of posttranscriptional gene silencing	0.02908322115048775	0.02908322115048775	+1	TP53,EGFR,AJUBA,NCOR1
PEPTIDYL-LYSINE MODIFICATION%GOBP%GO:0018205	peptidyl-lysine modification	0.02981923918546935	0.02981923918546935	+1	KDM6A,TET2,SETD2,EP300,BRCA2,EZH2
REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 73%400206	Regulation of lipid metabolism by PPARalpha	0.02991026679269802	0.02991026679269802	+1	EP300,SIN3A,TBL1XR1,NCOR1
REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001236	regulation of extrinsic apoptotic signaling pathway	0.02991026679269802	0.02991026679269802	+1	PTEN,AKT1,AR,BRCA1
POSITIVE REGULATION OF DNA BIOSYNTHETIC PROCESS%GOBP%GO:2000573	positive regulation of DNA biosynthetic process	0.030129426826199075	0.030129426826199075	+1	ATM,HGF,ATR
M-CSF%IOB%M-CSF	M-CSF	0.030129426826199075	0.030129426826199075	+1	PIK3R1,AKT1,PTPN11
HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.1	HSF1-dependent transactivation	0.030270730169744457	0.030270730169744457	+1	MTOR,EP300
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.2	Transcriptional regulation of pluripotent stem cells	0.030270730169744457	0.030270730169744457	+1	SMAD4,SMAD2
REGULATION OF ORGANELLE ASSEMBLY%GOBP%GO:1902115	regulation of organelle assembly	0.030270730169744457	0.030270730169744457	+1	ARHGAP35,NPM1,BRCA1,LRRK2,SMAD4
POSITIVE REGULATION OF LAMELLIPODIUM ASSEMBLY%GOBP%GO:0010592	positive regulation of lamellipodium assembly	0.030270730169744457	0.030270730169744457	+1	PIK3CA,PIK3R1
NEGATIVE REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION%GOBP%GO:0051154	negative regulation of striated muscle cell differentiation	0.030270730169744457	0.030270730169744457	+1	NOTCH1,SMAD4
REGULATION OF APOPTOSIS BY PARATHYROID HORMONE-RELATED PROTEIN%WIKIPATHWAYS_20200810%WP3872%HOMO SAPIENS	Regulation of Apoptosis by Parathyroid Hormone-related Protein	0.030270730169744457	0.030270730169744457	+1	AKT1,PIK3CG
POSITIVE REGULATION OF LEUKOCYTE APOPTOTIC PROCESS%GOBP%GO:2000108	positive regulation of leukocyte apoptotic process	0.030270730169744457	0.030270730169744457	+1	TP53,CDKN2A
RESPONSE TO LIPOPROTEIN PARTICLE%GOBP%GO:0055094	response to lipoprotein particle	0.030270730169744457	0.030270730169744457	+1	AKT1,TLR4
REGULATION OF CENTRIOLE REPLICATION%GOBP%GO:0046599	regulation of centriole replication	0.030270730169744457	0.030270730169744457	+1	NPM1,BRCA1
ENDOCRINE PANCREAS DEVELOPMENT%GOBP%GO:0031018	endocrine pancreas development	0.030270730169744457	0.030270730169744457	+1	AKT1,FOXA2
BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY	BIOCARTA_CERAMIDE_PATHWAY	0.030270730169744457	0.030270730169744457	+1	MAP3K1,MAP2K4
DNA DOUBLE-STRAND BREAK PROCESSING%GOBP%GO:0000729	DNA double-strand break processing	0.030270730169744457	0.030270730169744457	+1	ATM,BRCA1
VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20200810%WP4482%HOMO SAPIENS	Vitamin D in inflammatory diseases	0.030270730169744457	0.030270730169744457	+1	MAP3K1,SMAD4
NEGATIVE REGULATION OF MITOTIC SISTER CHROMATID SEPARATION%GOBP%GO:2000816	negative regulation of mitotic sister chromatid separation	0.030270730169744457	0.030270730169744457	+1	APC,ATM
HISTONE DEUBIQUITINATION%GOBP%GO:0016578	histone deubiquitination	0.030270730169744457	0.030270730169744457	+1	BAP1,ASXL1
E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 73%113510	E2F mediated regulation of DNA replication	0.030270730169744457	0.030270730169744457	+1	RB1,PPP2R1A
BONE MINERALIZATION%GOBP%GO:0030282	bone mineralization	0.030270730169744457	0.030270730169744457	+1	FGFR2,FGFR3
NEPHRIN FAMILY INTERACTIONS%REACTOME%R-HSA-373753.3	Nephrin family interactions	0.030270730169744457	0.030270730169744457	+1	PIK3CA,PIK3R1
WNT SIGNALING%WIKIPATHWAYS_20200810%WP428%HOMO SAPIENS	Wnt Signaling	0.03047268070966671	0.03047268070966671	+1	APC,CTNNB1,CCND1,SOX17
G2 M TRANSITION%REACTOME%R-HSA-69275.5	G2 M Transition	0.030738387744019102	0.030738387744019102	+1	TP53,AJUBA,EP300,CDKN1A,PPP2R1A
FC RECEPTOR SIGNALING PATHWAY%GOBP%GO:0038093	Fc receptor signaling pathway	0.030738387744019102	0.030738387744019102	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,KIT
POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS%GOBP%GO:1900182	positive regulation of protein localization to nucleus	0.031097609015013884	0.031097609015013884	+1	PIK3R1,CDH1,AKT1
POSITIVE REGULATION OF OSSIFICATION%GOBP%GO:0045778	positive regulation of ossification	0.031097609015013884	0.031097609015013884	+1	HGF,PTPN11,ACVR2A
REGULATION OF ENDOTHELIAL CELL PROLIFERATION%GOBP%GO:0001936	regulation of endothelial cell proliferation	0.031289151628825757	0.031289151628825757	+1	NF1,NRAS,AKT1,EGR3
MITOTIC G2-G2 M PHASES%REACTOME%R-HSA-453274.2	Mitotic G2-G2 M phases	0.03206149645325884	0.03206149645325884	+1	TP53,AJUBA,EP300,CDKN1A,PPP2R1A
HUNTINGTON DISEASE%PANTHER PATHWAY%P00029	Huntington disease	0.03216645921065096	0.03216645921065096	+1	TP53,MAP2K4,AKT1,EP300
POSITIVE REGULATION OF NIK/NF-KAPPAB SIGNALING%GOBP%GO:1901224	positive regulation of NIK/NF-kappaB signaling	0.03234939102674009	0.03234939102674009	+1	EGFR,TLR4,EP300
LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS	LPA receptor mediated events	0.03234939102674009	0.03234939102674009	+1	EGFR,PIK3R1,AKT1
NEGATIVE REGULATION OF PROTEIN UBIQUITINATION%GOBP%GO:0031397	negative regulation of protein ubiquitination	0.03234939102674009	0.03234939102674009	+1	AKT1,TAF1,RPL5
BLOOD VESSEL ENDOTHELIAL CELL MIGRATION%GOBP%GO:0043534	blood vessel endothelial cell migration	0.032610306776320874	0.032610306776320874	+1	AKT1,EGR3
BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY	BIOCARTA_NFKB_PATHWAY	0.032610306776320874	0.032610306776320874	+1	MAP3K1,TLR4
MESONEPHRIC TUBULE MORPHOGENESIS%GOBP%GO:0072171	mesonephric tubule morphogenesis	0.032610306776320874	0.032610306776320874	+1	GATA3,WT1
POSITIVE REGULATION OF CELL CYCLE G2/M PHASE TRANSITION%GOBP%GO:1902751	positive regulation of cell cycle G2/M phase transition	0.032610306776320874	0.032610306776320874	+1	NPM1,CCND1
NEGATIVE REGULATION OF CHROMOSOME SEPARATION%GOBP%GO:1905819	negative regulation of chromosome separation	0.032610306776320874	0.032610306776320874	+1	APC,ATM
PHOTODYNAMIC THERAPY-INDUCED NFE2L2 (NRF2) SURVIVAL SIGNALING%WIKIPATHWAYS_20200810%WP3612%HOMO SAPIENS	Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling	0.032610306776320874	0.032610306776320874	+1	KEAP1,NFE2L2
REGULATION OF KERATINOCYTE PROLIFERATION%GOBP%GO:0010837	regulation of keratinocyte proliferation	0.032610306776320874	0.032610306776320874	+1	TLR4,FGFR2
MYOBLAST DIFFERENTIATION%GOBP%GO:0045445	myoblast differentiation	0.032610306776320874	0.032610306776320874	+1	RB1,NOTCH1
RESPONSE TO GROWTH HORMONE%GOBP%GO:0060416	response to growth hormone	0.032610306776320874	0.032610306776320874	+1	PIK3R1,AKT1
INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033	Insulin IGF pathway-protein kinase B signaling cascade	0.032610306776320874	0.032610306776320874	+1	PIK3CA,PTEN
REGULATION OF B CELL RECEPTOR SIGNALING PATHWAY%GOBP%GO:0050855	regulation of B cell receptor signaling pathway	0.032610306776320874	0.032610306776320874	+1	RUNX1,CBFB
CELLULAR RESPONSE TO LIPOPROTEIN PARTICLE STIMULUS%GOBP%GO:0071402	cellular response to lipoprotein particle stimulus	0.032610306776320874	0.032610306776320874	+1	AKT1,TLR4
FC-EPSILON RECEPTOR SIGNALING PATHWAY%GOBP%GO:0038095	Fc-epsilon receptor signaling pathway	0.03282832486125364	0.03282832486125364	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4
MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 73%68877	Mitotic Prometaphase	0.03318817952080355	0.03318817952080355	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
REGULATION OF RESPONSE TO DRUG%GOBP%GO:2001023	regulation of response to drug	0.033442740426832485	0.033442740426832485	+1	NFE2L2,HGF,LRRK2
PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY	PID_CD8_TCR_DOWNSTREAM_PATHWAY	0.033442740426832485	0.033442740426832485	+1	KRAS,NRAS,BRAF
CARTILAGE DEVELOPMENT%GOBP%GO:0051216	cartilage development	0.033442740426832485	0.033442740426832485	+1	RUNX1,SOX9,FGFR3
ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20200810%WP474%HOMO SAPIENS	Endochondral Ossification	0.03472129040770127	0.03472129040770127	+1	AKT1,SOX9,FGFR3
AGE/RAGE PATHWAY%WIKIPATHWAYS_20200810%WP2324%HOMO SAPIENS	AGE/RAGE pathway	0.03472129040770127	0.03472129040770127	+1	EGFR,AKT1,SMAD2
PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY	PID_HDAC_CLASSI_PATHWAY	0.03472129040770127	0.03472129040770127	+1	EP300,SIN3A,NCOR1
SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I	Signaling events mediated by HDAC Class I	0.03472129040770127	0.03472129040770127	+1	EP300,SIN3A,NCOR1
ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20200810%WP4808%HOMO SAPIENS	Endochondral Ossification with Skeletal Dysplasias	0.03472129040770127	0.03472129040770127	+1	AKT1,SOX9,FGFR3
PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY	PID_LYSOPHOSPHOLIPID_PATHWAY	0.03472129040770127	0.03472129040770127	+1	EGFR,PIK3R1,AKT1
DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS	Downstream signaling in naive CD8+ T cells	0.03472129040770127	0.03472129040770127	+1	KRAS,NRAS,BRAF
POSITIVE REGULATION OF ERYTHROCYTE DIFFERENTIATION%GOBP%GO:0045648	positive regulation of erythrocyte differentiation	0.03499654738008976	0.03499654738008976	+1	ACVR1B,ACVR2A
POSITIVE REGULATION OF HISTONE ACETYLATION%GOBP%GO:0035066	positive regulation of histone acetylation	0.03499654738008976	0.03499654738008976	+1	BRCA1,SMAD4
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 73%9013508	NOTCH3 Intracellular Domain Regulates Transcription	0.03499654738008976	0.03499654738008976	+1	NOTCH1,EP300
ROLE OF OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20200810%WP3971%HOMO SAPIENS	Role of Osx and miRNAs in tooth development	0.03499654738008976	0.03499654738008976	+1	NOTCH1,CTNNB1
DENDRITIC CELL DIFFERENTIATION%GOBP%GO:0097028	dendritic cell differentiation	0.03499654738008976	0.03499654738008976	+1	FLT3,TGFBR2
BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY	BIOCARTA_CXCR4_PATHWAY	0.03499654738008976	0.03499654738008976	+1	PIK3CA,PIK3R1
RESPONSE TO STEROL%GOBP%GO:0036314	response to sterol	0.03499654738008976	0.03499654738008976	+1	TGFBR2,SMAD2
REGULATION OF MICROTUBULE DEPOLYMERIZATION%GOBP%GO:0031114	regulation of microtubule depolymerization	0.03499654738008976	0.03499654738008976	+1	APC,NAV3
INTERLEUKIN-6 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 73%6783589	Interleukin-6 family signaling	0.03499654738008976	0.03499654738008976	+1	PTPN11,LIFR
NEGATIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT%GOBP%GO:0070168	negative regulation of biomineral tissue development	0.03499654738008976	0.03499654738008976	+1	NOTCH1,SOX9
PROTEIN KINASE B SIGNALING%GOBP%GO:0043491	protein kinase B signaling	0.03499654738008976	0.03499654738008976	+1	PTEN,AKT1
POSITIVE REGULATION OF MATRIX METALLOPEPTIDASE SECRETION%GOBP%GO:1904466	positive regulation of matrix metallopeptidase secretion	0.035097068141072114	0.035097068141072114	+1	TLR4
REGULATION OF CELLULAR RESPONSE TO X-RAY%GOBP%GO:2000683	regulation of cellular response to X-ray	0.035097068141072114	0.035097068141072114	+1	GATA3
HISTONE H2B ACETYLATION%GOBP%GO:0043969	histone H2B acetylation	0.035097068141072114	0.035097068141072114	+1	EP300
ACTIVATION-INDUCED CELL DEATH OF T CELLS%GOBP%GO:0006924	activation-induced cell death of T cells	0.035097068141072114	0.035097068141072114	+1	AKT1
NEGATIVE REGULATION OF MAINTENANCE OF MITOTIC SISTER CHROMATID COHESION, TELOMERIC%GOBP%GO:1904908	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	0.035097068141072114	0.035097068141072114	+1	ATRX
REGULATION OF MAINTENANCE OF MITOTIC SISTER CHROMATID COHESION, TELOMERIC%GOBP%GO:1904907	regulation of maintenance of mitotic sister chromatid cohesion, telomeric	0.035097068141072114	0.035097068141072114	+1	ATRX
POSITIVE REGULATION OF WOUND HEALING, SPREADING OF EPIDERMAL CELLS%GOBP%GO:1903691	positive regulation of wound healing, spreading of epidermal cells	0.035097068141072114	0.035097068141072114	+1	MTOR
REGULATION OF LYMPHOCYTE DIFFERENTIATION%GOBP%GO:0045619	regulation of lymphocyte differentiation	0.035097068141072114	0.035097068141072114	+1	GATA3,RUNX1,TGFBR2,CBFB
VENTRICULAR ZONE NEUROBLAST DIVISION%GOBP%GO:0021847	ventricular zone neuroblast division	0.035097068141072114	0.035097068141072114	+1	FGFR2
MELANOCYTE MIGRATION%GOBP%GO:0097324	melanocyte migration	0.035097068141072114	0.035097068141072114	+1	KIT
POSITIVE REGULATION OF METANEPHRIC URETERIC BUD DEVELOPMENT%GOBP%GO:2001076	positive regulation of metanephric ureteric bud development	0.035097068141072114	0.035097068141072114	+1	WT1
NEGATIVE REGULATION OF MITOTIC CELL CYCLE DNA REPLICATION%GOBP%GO:1903464	negative regulation of mitotic cell cycle DNA replication	0.035097068141072114	0.035097068141072114	+1	CHEK2
LATERAL SPROUTING FROM AN EPITHELIUM%GOBP%GO:0060601	lateral sprouting from an epithelium	0.035097068141072114	0.035097068141072114	+1	FGFR2
RESPONSE TO INSULIN-LIKE GROWTH FACTOR STIMULUS%GOBP%GO:1990418	response to insulin-like growth factor stimulus	0.035097068141072114	0.035097068141072114	+1	AKT1
MAMMARY GLAND FORMATION%GOBP%GO:0060592	mammary gland formation	0.035097068141072114	0.035097068141072114	+1	FGFR2
NEGATIVE REGULATION OF LATE ENDOSOME TO LYSOSOME TRANSPORT%GOBP%GO:1902823	negative regulation of late endosome to lysosome transport	0.035097068141072114	0.035097068141072114	+1	LRRK2
RENAL VESICLE INDUCTION%GOBP%GO:0072034	renal vesicle induction	0.035097068141072114	0.035097068141072114	+1	SOX9
BRANCHING INVOLVED IN PROSTATE GLAND MORPHOGENESIS%GOBP%GO:0060442	branching involved in prostate gland morphogenesis	0.035097068141072114	0.035097068141072114	+1	FGFR2
TREHALOSE METABOLIC PROCESS%GOBP%GO:0005991	trehalose metabolic process	0.035097068141072114	0.035097068141072114	+1	BRAF
GLIAL CELL APOPTOTIC PROCESS%GOBP%GO:0034349	glial cell apoptotic process	0.035097068141072114	0.035097068141072114	+1	TP53
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN MAMMARY GLAND SPECIFICATION%GOBP%GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	0.035097068141072114	0.035097068141072114	+1	FGFR2
NEGATIVE REGULATION OF MITOTIC CELL CYCLE, EMBRYONIC%GOBP%GO:0045976	negative regulation of mitotic cell cycle, embryonic	0.035097068141072114	0.035097068141072114	+1	CTNNB1
ZYGOTIC SPECIFICATION OF DORSAL/VENTRAL AXIS%GOBP%GO:0007352	zygotic specification of dorsal/ventral axis	0.035097068141072114	0.035097068141072114	+1	SMAD2
PERIPHERAL NERVOUS SYSTEM MYELIN MAINTENANCE%GOBP%GO:0032287	peripheral nervous system myelin maintenance	0.035097068141072114	0.035097068141072114	+1	PRX
CENTRAL NERVOUS SYSTEM MORPHOGENESIS%GOBP%GO:0021551	central nervous system morphogenesis	0.035097068141072114	0.035097068141072114	+1	ERBB4
REGULATION OF LOCOMOTOR RHYTHM%GOBP%GO:1904059	regulation of locomotor rhythm	0.035097068141072114	0.035097068141072114	+1	MTOR
REGULATION OF BMP SIGNALING PATHWAY%GOBP%GO:0030510	regulation of BMP signaling pathway	0.035097068141072114	0.035097068141072114	+1	NOTCH1,SMAD4,SMAD2
REGULATION OF HISTONE H3-K27 ACETYLATION%GOBP%GO:1901674	regulation of histone H3-K27 acetylation	0.035097068141072114	0.035097068141072114	+1	SIN3A
NEGATIVE REGULATION OF HEPATOCYTE PROLIFERATION%GOBP%GO:2000346	negative regulation of hepatocyte proliferation	0.035097068141072114	0.035097068141072114	+1	FBXW7
NEGATIVE REGULATION OF CELL PROLIFERATION INVOLVED IN HEART VALVE MORPHOGENESIS%GOBP%GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	0.035097068141072114	0.035097068141072114	+1	NOTCH1
REPLICATIVE CELL AGING%GOBP%GO:0001302	replicative cell aging	0.035097068141072114	0.035097068141072114	+1	CHEK2
MAMMARY GLAND SPECIFICATION%GOBP%GO:0060594	mammary gland specification	0.035097068141072114	0.035097068141072114	+1	FGFR2
DENDRITIC CELL CYTOKINE PRODUCTION%GOBP%GO:0002371	dendritic cell cytokine production	0.035097068141072114	0.035097068141072114	+1	KIT
STEM CELL FATE SPECIFICATION%GOBP%GO:0048866	stem cell fate specification	0.035097068141072114	0.035097068141072114	+1	SOX9
LUNG-ASSOCIATED MESENCHYME DEVELOPMENT%GOBP%GO:0060484	lung-associated mesenchyme development	0.035097068141072114	0.035097068141072114	+1	FGFR2
REGULATION OF B CELL TOLERANCE INDUCTION%GOBP%GO:0002661	regulation of B cell tolerance induction	0.035097068141072114	0.035097068141072114	+1	TGFBR2
REGULATION OF METANEPHRIC URETERIC BUD DEVELOPMENT%GOBP%GO:2001074	regulation of metanephric ureteric bud development	0.035097068141072114	0.035097068141072114	+1	WT1
POSITIVE REGULATION OF COLLAGEN FIBRIL ORGANIZATION%GOBP%GO:1904028	positive regulation of collagen fibril organization	0.035097068141072114	0.035097068141072114	+1	RB1
OLIGODENDROCYTE APOPTOTIC PROCESS%GOBP%GO:0097252	oligodendrocyte apoptotic process	0.035097068141072114	0.035097068141072114	+1	TP53
NEGATIVE REGULATION OF FEMALE GONAD DEVELOPMENT%GOBP%GO:2000195	negative regulation of female gonad development	0.035097068141072114	0.035097068141072114	+1	WT1
GONADOTROPIN SECRETION%GOBP%GO:0032274	gonadotropin secretion	0.035097068141072114	0.035097068141072114	+1	TBX3
EMBRYONIC FOREGUT MORPHOGENESIS%GOBP%GO:0048617	embryonic foregut morphogenesis	0.035097068141072114	0.035097068141072114	+1	SOX17
ENDODERMAL DIGESTIVE TRACT MORPHOGENESIS%GOBP%GO:0061031	endodermal digestive tract morphogenesis	0.035097068141072114	0.035097068141072114	+1	SOX17
NEGATIVE REGULATION OF MAP KINASE ACTIVITY%GOBP%GO:0043407	negative regulation of MAP kinase activity	0.035097068141072114	0.035097068141072114	+1	NF1,PPP2R1A,MAPK8IP1
MAMMARY GLAND INVOLUTION%GOBP%GO:0060056	mammary gland involution	0.035097068141072114	0.035097068141072114	+1	ELF3
RETINAL ROD CELL DIFFERENTIATION%GOBP%GO:0060221	retinal rod cell differentiation	0.035097068141072114	0.035097068141072114	+1	SOX9
REGULATION OF HISTONE H4-K20 METHYLATION%GOBP%GO:0070510	regulation of histone H4-K20 methylation	0.035097068141072114	0.035097068141072114	+1	BRCA1
FOREBRAIN VENTRICULAR ZONE PROGENITOR CELL DIVISION%GOBP%GO:0021869	forebrain ventricular zone progenitor cell division	0.035097068141072114	0.035097068141072114	+1	FGFR2
CELLULAR RESPONSE TO NITROSATIVE STRESS%GOBP%GO:0071500	cellular response to nitrosative stress	0.035097068141072114	0.035097068141072114	+1	ATM
POSITIVE REGULATION OF HISTONE H4-K16 ACETYLATION%GOBP%GO:2000620	positive regulation of histone H4-K16 acetylation	0.035097068141072114	0.035097068141072114	+1	BRCA1
NEGATIVE REGULATION OF MYOFIBROBLAST DIFFERENTIATION%GOBP%GO:1904761	negative regulation of myofibroblast differentiation	0.035097068141072114	0.035097068141072114	+1	RB1
NEGATIVE REGULATION OF INTERLEUKIN-23 PRODUCTION%GOBP%GO:0032707	negative regulation of interleukin-23 production	0.035097068141072114	0.035097068141072114	+1	TLR4
RHYTHMIC SYNAPTIC TRANSMISSION%GOBP%GO:0060024	rhythmic synaptic transmission	0.035097068141072114	0.035097068141072114	+1	PTEN
NEURAL CREST CELL FATE SPECIFICATION%GOBP%GO:0014036	neural crest cell fate specification	0.035097068141072114	0.035097068141072114	+1	SOX9
POSITIVE REGULATION OF NODAL SIGNALING PATHWAY INVOLVED IN DETERMINATION OF LATERAL MESODERM LEFT/RIGHT ASYMMETRY%GOBP%GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	0.035097068141072114	0.035097068141072114	+1	SMAD2
KIT SIGNALING PATHWAY%GOBP%GO:0038109	Kit signaling pathway	0.035097068141072114	0.035097068141072114	+1	KIT
CARDIAC VASCULAR SMOOTH MUSCLE CELL DEVELOPMENT%GOBP%GO:0060948	cardiac vascular smooth muscle cell development	0.035097068141072114	0.035097068141072114	+1	NOTCH1
DNA STRAND RENATURATION%GOBP%GO:0000733	DNA strand renaturation	0.035097068141072114	0.035097068141072114	+1	TP53
NEGATIVE REGULATION OF PROTEIN AUTOUBIQUITINATION%GOBP%GO:1905524	negative regulation of protein autoubiquitination	0.035097068141072114	0.035097068141072114	+1	TAF1
MYELOID PROGENITOR CELL DIFFERENTIATION%GOBP%GO:0002318	myeloid progenitor cell differentiation	0.035097068141072114	0.035097068141072114	+1	FLT3
REGULATION OF MITOTIC CELL CYCLE DNA REPLICATION%GOBP%GO:1903463	regulation of mitotic cell cycle DNA replication	0.035097068141072114	0.035097068141072114	+1	CHEK2
NEGATIVE REGULATION OF APOPTOTIC PROCESS IN BONE MARROW%GOBP%GO:0071866	negative regulation of apoptotic process in bone marrow	0.035097068141072114	0.035097068141072114	+1	FGFR2
LEFT VENTRICULAR CARDIAC MUSCLE TISSUE MORPHOGENESIS%GOBP%GO:0003220	left ventricular cardiac muscle tissue morphogenesis	0.035097068141072114	0.035097068141072114	+1	SMAD4
CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS%GOBP%GO:0061323	cell proliferation involved in heart morphogenesis	0.035097068141072114	0.035097068141072114	+1	TGFBR2
CELLULAR RESPONSE TO FOLLICLE-STIMULATING HORMONE STIMULUS%GOBP%GO:0071372	cellular response to follicle-stimulating hormone stimulus	0.035097068141072114	0.035097068141072114	+1	NOTCH1
MAST CELL DIFFERENTIATION%GOBP%GO:0060374	mast cell differentiation	0.035097068141072114	0.035097068141072114	+1	KIT
NEGATIVE REGULATION OF INTEGRIN BIOSYNTHETIC PROCESS%GOBP%GO:0045720	negative regulation of integrin biosynthetic process	0.035097068141072114	0.035097068141072114	+1	AR
CANONICAL WNT SIGNALING PATHWAY INVOLVED IN POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	0.035097068141072114	0.035097068141072114	+1	CTNNB1
NEGATIVE REGULATION OF VACUOLAR TRANSPORT%GOBP%GO:1903336	negative regulation of vacuolar transport	0.035097068141072114	0.035097068141072114	+1	LRRK2
POSITIVE REGULATION OF OXIDATIVE STRESS-INDUCED NEURON INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	0.035097068141072114	0.035097068141072114	+1	FBXW7
POSITIVE REGULATION OF B CELL TOLERANCE INDUCTION%GOBP%GO:0002663	positive regulation of B cell tolerance induction	0.035097068141072114	0.035097068141072114	+1	TGFBR2
POSTERIOR MESONEPHRIC TUBULE DEVELOPMENT%GOBP%GO:0072166	posterior mesonephric tubule development	0.035097068141072114	0.035097068141072114	+1	WT1
EPITHELIAL CELL PROLIFERATION INVOLVED IN SALIVARY GLAND MORPHOGENESIS%GOBP%GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	0.035097068141072114	0.035097068141072114	+1	FGFR2
NEGATIVE REGULATION OF NEUROBLAST PROLIFERATION%GOBP%GO:0007406	negative regulation of neuroblast proliferation	0.035097068141072114	0.035097068141072114	+1	NF1
DETECTION OF FUNGUS%GOBP%GO:0016046	detection of fungus	0.035097068141072114	0.035097068141072114	+1	TLR4
REGULATION OF METANEPHRIC GLOMERULAR MESANGIAL CELL PROLIFERATION%GOBP%GO:0072301	regulation of metanephric glomerular mesangial cell proliferation	0.035097068141072114	0.035097068141072114	+1	WT1
CORONARY VEIN MORPHOGENESIS%GOBP%GO:0003169	coronary vein morphogenesis	0.035097068141072114	0.035097068141072114	+1	NOTCH1
FOREGUT MORPHOGENESIS%GOBP%GO:0007440	foregut morphogenesis	0.035097068141072114	0.035097068141072114	+1	SOX17
PROSTATE GLANDULAR ACINUS DEVELOPMENT%GOBP%GO:0060525	prostate glandular acinus development	0.035097068141072114	0.035097068141072114	+1	FGFR2
CELLULAR RESPONSE TO STEM CELL FACTOR STIMULUS%GOBP%GO:0036216	cellular response to stem cell factor stimulus	0.035097068141072114	0.035097068141072114	+1	KIT
POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL%GOBP%GO:1903322	positive regulation of protein modification by small protein conjugation or removal	0.035097068141072114	0.035097068141072114	+1	PTEN,FBXW7,BRCA1,LRRK2
ADRENAL CORTEX DEVELOPMENT%GOBP%GO:0035801	adrenal cortex development	0.035097068141072114	0.035097068141072114	+1	WT1
MAST CELL CYTOKINE PRODUCTION%GOBP%GO:0032762	mast cell cytokine production	0.035097068141072114	0.035097068141072114	+1	KIT
RRNA EXPORT FROM NUCLEUS%GOBP%GO:0006407	rRNA export from nucleus	0.035097068141072114	0.035097068141072114	+1	NPM1
TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%R-HSA-3642279.1	TGFBR2 MSI Frameshift Mutants in Cancer	0.035097068141072114	0.035097068141072114	+1	TGFBR2
EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 73%9630791	Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	0.035097068141072114	0.035097068141072114	+1	CDKN2A
NEGATIVE REGULATION OF TRIGLYCERIDE BIOSYNTHETIC PROCESS%GOBP%GO:0010868	negative regulation of triglyceride biosynthetic process	0.035097068141072114	0.035097068141072114	+1	FBXW7
DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.2	Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	0.035097068141072114	0.035097068141072114	+1	CDKN2A
NEGATIVE REGULATION OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR SIGNALING PATHWAY%GOBP%GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	0.035097068141072114	0.035097068141072114	+1	ASXL1
RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 73%8951911	RUNX3 regulates RUNX1-mediated transcription	0.035097068141072114	0.035097068141072114	+1	CBFB
REGULATION OF MYOFIBROBLAST DIFFERENTIATION%GOBP%GO:1904760	regulation of myofibroblast differentiation	0.035097068141072114	0.035097068141072114	+1	RB1
REGULATION OF APOPTOTIC PROCESS IN BONE MARROW%GOBP%GO:0071865	regulation of apoptotic process in bone marrow	0.035097068141072114	0.035097068141072114	+1	FGFR2
FASCICULATION OF MOTOR NEURON AXON%GOBP%GO:0097156	fasciculation of motor neuron axon	0.035097068141072114	0.035097068141072114	+1	EPHA3
ACTIVATION OF PHOSPHOLIPASE A2 ACTIVITY BY CALCIUM-MEDIATED SIGNALING%GOBP%GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling	0.035097068141072114	0.035097068141072114	+1	EGFR
REGULATION OF BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS%GOBP%GO:0060693	regulation of branching involved in salivary gland morphogenesis	0.035097068141072114	0.035097068141072114	+1	HGF
LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 73%9022538	Loss of MECP2 binding ability to 5mC-DNA	0.035097068141072114	0.035097068141072114	+1	SIN3A
EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.2	Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	0.035097068141072114	0.035097068141072114	+1	CDKN2A
CARDIAC MUSCLE TISSUE REGENERATION%GOBP%GO:0061026	cardiac muscle tissue regeneration	0.035097068141072114	0.035097068141072114	+1	ERBB4
REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.1	Regulation of TP53 Expression	0.035097068141072114	0.035097068141072114	+1	TP53
CIRCADIAN CLOCK%REACTOME%R-HSA-400253.3	Circadian Clock	0.035097068141072114	0.035097068141072114	+1	EP300,TBL1XR1,NCOR1
RESPONSE TO STEM CELL FACTOR%GOBP%GO:0036215	response to stem cell factor	0.035097068141072114	0.035097068141072114	+1	KIT
REGULATION OF CELL PROLIFERATION INVOLVED IN OUTFLOW TRACT MORPHOGENESIS%GOBP%GO:1901963	regulation of cell proliferation involved in outflow tract morphogenesis	0.035097068141072114	0.035097068141072114	+1	CTNNB1
PRIMARY SEX DETERMINATION%GOBP%GO:0007538	primary sex determination	0.035097068141072114	0.035097068141072114	+1	SOX9
ADRENAL CORTEX FORMATION%GOBP%GO:0035802	adrenal cortex formation	0.035097068141072114	0.035097068141072114	+1	WT1
TRANSCRIPTION FACTOR CATABOLIC PROCESS%GOBP%GO:0036369	transcription factor catabolic process	0.035097068141072114	0.035097068141072114	+1	TAF1
BUTYRATE-INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20200810%WP2366%HOMO SAPIENS	Butyrate-induced histone acetylation	0.035097068141072114	0.035097068141072114	+1	AKT1
ACTIVATION OF MAPK ACTIVITY%GOBP%GO:0000187	activation of MAPK activity	0.03539765754524336	0.03539765754524336	+1	MAP2K4,TLR4,LRRK2,KIT
TRANSCRIPTION ELONGATION FROM RNA POLYMERASE II PROMOTER%GOBP%GO:0006368	transcription elongation from RNA polymerase II promoter	0.03549955628265933	0.03549955628265933	+1	SETD2,CDK12,ERCC2
POSITIVE REGULATION OF HISTONE MODIFICATION%GOBP%GO:0031058	positive regulation of histone modification	0.03549955628265933	0.03549955628265933	+1	CTNNB1,BRCA1,SMAD4
BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY	BIOCARTA_STRESS_PATHWAY	0.0358050719754882	0.0358050719754882	+1	MAP3K1,MAP2K4
CHEMICAL SYNAPTIC TRANSMISSION, POSTSYNAPTIC%GOBP%GO:0099565	chemical synaptic transmission, postsynaptic	0.0358050719754882	0.0358050719754882	+1	AKT1,LRRK2
PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY	PID_MYC_PATHWAY	0.0358050719754882	0.0358050719754882	+1	CDKN2A,FBXW7
REGULATION OF FATTY ACID OXIDATION%GOBP%GO:0046320	regulation of fatty acid oxidation	0.0358050719754882	0.0358050719754882	+1	AKT1,SOX9
REGULATION OF INTERFERON-ALPHA PRODUCTION%GOBP%GO:0032647	regulation of interferon-alpha production	0.0358050719754882	0.0358050719754882	+1	TLR4,SETD2
DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 73%2173788	Downregulation of TGF-beta receptor signaling	0.0358050719754882	0.0358050719754882	+1	TGFBR2,SMAD2
G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-HSA-392451.3	G beta:gamma signalling through PI3Kgamma	0.0358050719754882	0.0358050719754882	+1	AKT1,PIK3CG
NEGATIVE REGULATION OF WNT SIGNALING PATHWAY%GOBP%GO:0030178	negative regulation of Wnt signaling pathway	0.0359814856833824	0.0359814856833824	+1	APC,STK11,SOX9,SOX17,AXIN2
REGULATION OF STRESS-ACTIVATED MAPK CASCADE%GOBP%GO:0032872	regulation of stress-activated MAPK cascade	0.0359814856833824	0.0359814856833824	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
CELLULAR RESPONSE TO STARVATION%GOBP%GO:0009267	cellular response to starvation	0.03615273750068746	0.03615273750068746	+1	TP53,MTOR,LRRK2,CDKN1A
NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.1	Nonhomologous End-Joining (NHEJ)	0.03666882856407244	0.03666882856407244	+1	ATM,BRCA1,HIST1H2BD
REGULATION OF HEMOSTASIS%GOBP%GO:1900046	regulation of hemostasis	0.03666882856407244	0.03666882856407244	+1	TLR4,PDGFRA,FOXA2
POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION%GOBP%GO:0045639	positive regulation of myeloid cell differentiation	0.03666882856407244	0.03666882856407244	+1	RUNX1,ACVR1B,ACVR2A
REGULATION OF BLOOD COAGULATION%GOBP%GO:0030193	regulation of blood coagulation	0.03666882856407244	0.03666882856407244	+1	TLR4,PDGFRA,FOXA2
REGULATION OF STRESS-ACTIVATED PROTEIN KINASE SIGNALING CASCADE%GOBP%GO:0070302	regulation of stress-activated protein kinase signaling cascade	0.037362197594862846	0.037362197594862846	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
WNT SIGNALING PATHWAY%GOBP%GO:0016055	Wnt signaling pathway	0.037362197594862846	0.037362197594862846	+1	PTEN,APC,GATA3,CTNNB1,LRRK2
LIMB DEVELOPMENT%GOBP%GO:0060173	limb development	0.03799391065117363	0.03799391065117363	+1	CTNNB1,TBX3,FGFR2
REGULATION OF HEMATOPOIETIC STEM CELL DIFFERENTIATION%GOBP%GO:1902036	regulation of hematopoietic stem cell differentiation	0.03799391065117363	0.03799391065117363	+1	GATA3,RUNX1,CBFB
APPENDAGE DEVELOPMENT%GOBP%GO:0048736	appendage development	0.03799391065117363	0.03799391065117363	+1	CTNNB1,TBX3,FGFR2
REGULATION OF PROTEIN TARGETING%GOBP%GO:1903533	regulation of protein targeting	0.03799391065117363	0.03799391065117363	+1	FBXW7,BAP1,LRRK2
NEGATIVE REGULATION OF CD4-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	0.03813375783472876	0.03813375783472876	+1	RUNX1,CBFB
ST_INTERLEUKIN_4_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_4_PATHWAY	ST_INTERLEUKIN_4_PATHWAY	0.03813375783472876	0.03813375783472876	+1	PIK3CA,AKT1
PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY	PID_P38_MKK3_6PATHWAY	0.03813375783472876	0.03813375783472876	+1	MAP3K1,ATM
C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY	C-MYC pathway	0.03813375783472876	0.03813375783472876	+1	CDKN2A,FBXW7
EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20200810%WP581%HOMO SAPIENS	EPO Receptor Signaling	0.03813375783472876	0.03813375783472876	+1	AKT1,PIK3CG
GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK	Glypican 1 network	0.03813375783472876	0.03813375783472876	+1	TGFBR2,SMAD2
INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-HSA-912526.4	Interleukin receptor SHC signaling	0.03813375783472876	0.03813375783472876	+1	PIK3CA,PIK3R1
FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839124.2	FGFR1 mutant receptor activation	0.03813375783472876	0.03813375783472876	+1	PIK3CA,PIK3R1
UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20200810%WP4925%HOMO SAPIENS	Unfolded protein response	0.03813375783472876	0.03813375783472876	+1	TP53,NFE2L2
REGULATION OF REGULATORY T CELL DIFFERENTIATION%GOBP%GO:0045589	regulation of regulatory T cell differentiation	0.03813375783472876	0.03813375783472876	+1	RUNX1,CBFB
POSITIVE REGULATION OF DNA REPLICATION%GOBP%GO:0045740	positive regulation of DNA replication	0.03813375783472876	0.03813375783472876	+1	EGFR,ATRX
BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY	BIOCARTA_VIP_PATHWAY	0.03813375783472876	0.03813375783472876	+1	MAP3K1,EGR3
CD40%IOB%CD40	CD40	0.03813375783472876	0.03813375783472876	+1	PIK3R1,AKT1
CELL-CELL SIGNALING BY WNT%GOBP%GO:0198738	cell-cell signaling by wnt	0.03857878377683947	0.03857878377683947	+1	PTEN,APC,GATA3,CTNNB1,LRRK2
CELLULAR RESPONSE TO INSULIN STIMULUS%GOBP%GO:0032869	cellular response to insulin stimulus	0.03862255466081819	0.03862255466081819	+1	PIK3CA,APC,PIK3R1,AKT1
NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS%GOBP%GO:0090288	negative regulation of cellular response to growth factor stimulus	0.03862255466081819	0.03862255466081819	+1	GATA3,NOTCH1,TGFBR2,SMAD2
POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION%GOBP%GO:0010634	positive regulation of epithelial cell migration	0.03862255466081819	0.03862255466081819	+1	GATA3,AKT1,SOX9,MTOR
REGULATION OF COAGULATION%GOBP%GO:0050818	regulation of coagulation	0.03908979223507208	0.03908979223507208	+1	TLR4,PDGFRA,FOXA2
NON-GENOMIC ACTIONS OF 1,25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20200810%WP4341%HOMO SAPIENS	Non-genomic actions of 1,25 dihydroxyvitamin D3	0.03908979223507208	0.03908979223507208	+1	KRAS,NRAS,TLR4
FORMATION OF PRIMARY GERM LAYER%GOBP%GO:0001704	formation of primary germ layer	0.03908979223507208	0.03908979223507208	+1	SETD2,SOX17,SMAD2
CELLULAR RESPONSE TO TUMOR NECROSIS FACTOR%GOBP%GO:0071356	cellular response to tumor necrosis factor	0.03923086551426619	0.03923086551426619	+1	TP53,GATA3,NFE2L2,AKT1,BRCA1
G2/M TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:0000086	G2/M transition of mitotic cell cycle	0.03953663581857224	0.03953663581857224	+1	AJUBA,CHEK2,CDKN1A,PPP2R1A
STEROL REGULATORY ELEMENT-BINDING PROTEINS (SREBP) SIGNALLING%WIKIPATHWAYS_20200810%WP1982%HOMO SAPIENS	Sterol Regulatory Element-Binding Proteins (SREBP) signalling	0.040490598471918764	0.040490598471918764	+1	PIK3CA,AKT1,MTOR
DOUBLE-STRAND BREAK REPAIR VIA NONHOMOLOGOUS END JOINING%GOBP%GO:0006303	double-strand break repair via nonhomologous end joining	0.040490598471918764	0.040490598471918764	+1	ATM,BRCA1,POLQ
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-HSA-8939236.1	RUNX1 regulates transcription of genes involved in differentiation of HSCs	0.04049969958475404	0.04049969958475404	+1	GATA3,RUNX1,CBFB,HIST1H2BD
ST_MYOCYTE_AD_PATHWAY%MSIGDB_C2%ST_MYOCYTE_AD_PATHWAY	ST_MYOCYTE_AD_PATHWAY	0.04051327561661729	0.04051327561661729	+1	APC,AKT1
NEGATIVE REGULATION OF ENDOTHELIAL CELL APOPTOTIC PROCESS%GOBP%GO:2000352	negative regulation of endothelial cell apoptotic process	0.04051327561661729	0.04051327561661729	+1	GATA3,NFE2L2
FOLLICLE STIMULATING HORMONE (FSH) SIGNALING PATHWAY%WIKIPATHWAYS_20200810%WP2035%HOMO SAPIENS	Follicle Stimulating Hormone (FSH) signaling pathway	0.04051327561661729	0.04051327561661729	+1	AKT1,MTOR
DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 73%8863795	Downregulation of ERBB2 signaling	0.04051327561661729	0.04051327561661729	+1	EGFR,AKT1
PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY	PID_GLYPICAN_1PATHWAY	0.04051327561661729	0.04051327561661729	+1	TGFBR2,SMAD2
POSITIVE REGULATION OF PEPTIDYL-LYSINE ACETYLATION%GOBP%GO:2000758	positive regulation of peptidyl-lysine acetylation	0.04051327561661729	0.04051327561661729	+1	BRCA1,SMAD4
POSITIVE REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS%GOBP%GO:0045429	positive regulation of nitric oxide biosynthetic process	0.04051327561661729	0.04051327561661729	+1	AKT1,TLR4
MITOTIC G2/M TRANSITION CHECKPOINT%GOBP%GO:0044818	mitotic G2/M transition checkpoint	0.04051327561661729	0.04051327561661729	+1	ATM,CDKN1A
CELLULAR RESPONSE TO CADMIUM ION%GOBP%GO:0071276	cellular response to cadmium ion	0.04051327561661729	0.04051327561661729	+1	EGFR,AKT1
REGULATION OF CHONDROCYTE DIFFERENTIATION%GOBP%GO:0032330	regulation of chondrocyte differentiation	0.04051327561661729	0.04051327561661729	+1	SOX9,PTPN11
MODULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL%GOBP%GO:0098815	modulation of excitatory postsynaptic potential	0.04051327561661729	0.04051327561661729	+1	PTEN,LRRK2
NADP METABOLIC PROCESS%GOBP%GO:0006739	NADP metabolic process	0.04051327561661729	0.04051327561661729	+1	IDH1,IDH2
LEUKOCYTE HOMEOSTASIS%GOBP%GO:0001776	leukocyte homeostasis	0.04051327561661729	0.04051327561661729	+1	FLT3,AKT1
CELL CYCLE G2/M PHASE TRANSITION%GOBP%GO:0044839	cell cycle G2/M phase transition	0.04125007636283012	0.04125007636283012	+1	AJUBA,CHEK2,CDKN1A,PPP2R1A
PROTEIN DEPHOSPHORYLATION%GOBP%GO:0006470	protein dephosphorylation	0.04125007636283012	0.04125007636283012	+1	PTEN,STK11,PPP2R1A,PTPN11
REGULATION OF TRANSLATIONAL INITIATION%GOBP%GO:0006446	regulation of translational initiation	0.041612568859051347	0.041612568859051347	+1	NPM1,MTOR,EIF4A2
REGULATION OF GLUCOSE METABOLIC PROCESS%GOBP%GO:0010906	regulation of glucose metabolic process	0.041612568859051347	0.041612568859051347	+1	AKT1,EP300,FOXA2
PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 73%212300	PRC2 methylates histones and DNA	0.041612568859051347	0.041612568859051347	+1	DNMT3A,HIST1H2BD,EZH2
MYELOID LEUKOCYTE DIFFERENTIATION%GOBP%GO:0002573	myeloid leukocyte differentiation	0.041612568859051347	0.041612568859051347	+1	CEBPA,KIT,TGFBR2
HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_LATE	HALLMARK_ESTROGEN_RESPONSE_LATE	0.04197633982853358	0.04197633982853358	+1	CDH1,IDH2,CCND1,FGFR3,EGR3
CAMERA-TYPE EYE DEVELOPMENT%GOBP%GO:0043010	camera-type eye development	0.04215861449620622	0.04215861449620622	+1	NF1,SOX9,WT1,PDGFRA
MRNA PROCESSING%WIKIPATHWAYS_20200810%WP411%HOMO SAPIENS	mRNA Processing	0.04215861449620622	0.04215861449620622	+1	U2AF1,SF3B1,SMC1A,SPOP
HALLMARK_HYPOXIA%MSIGDB_C2%HALLMARK_HYPOXIA	HALLMARK_HYPOXIA	0.042737227609618025	0.042737227609618025	+1	VHL,EGFR,MAP3K1,CDKN1B,CDKN1A
REGULATION OF DENDRITIC SPINE MORPHOGENESIS%GOBP%GO:0061001	regulation of dendritic spine morphogenesis	0.042789593524606345	0.042789593524606345	+1	PTEN,LRRK2
ACTIVATION OF MAPKK ACTIVITY%GOBP%GO:0000186	activation of MAPKK activity	0.042789593524606345	0.042789593524606345	+1	BRAF,LRRK2
IL-7%NETPATH%IL-7	IL-7	0.042789593524606345	0.042789593524606345	+1	PIK3R1,AKT1
GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20200810%WP2361%HOMO SAPIENS	Gastric Cancer Network 1	0.042789593524606345	0.042789593524606345	+1	APC,NOTCH1
IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS	IL8- and CXCR1-mediated signaling events	0.042789593524606345	0.042789593524606345	+1	AKT1,PIK3CG
OLIGODENDROCYTE DIFFERENTIATION%GOBP%GO:0048709	oligodendrocyte differentiation	0.042789593524606345	0.042789593524606345	+1	PTEN,SOX9
REGULATION OF CARBOHYDRATE CATABOLIC PROCESS%GOBP%GO:0043470	regulation of carbohydrate catabolic process	0.042789593524606345	0.042789593524606345	+1	TP53,EP300,NCOR1
POSITIVE REGULATION OF INTERFERON-BETA PRODUCTION%GOBP%GO:0032728	positive regulation of interferon-beta production	0.042789593524606345	0.042789593524606345	+1	TLR4,PTPN11
SIGNALING BY BMP%REACTOME%R-HSA-201451.4	Signaling by BMP	0.042789593524606345	0.042789593524606345	+1	SMAD4,ACVR2A
REGULATION OF ALPHA-BETA T CELL PROLIFERATION%GOBP%GO:0046640	regulation of alpha-beta T cell proliferation	0.042789593524606345	0.042789593524606345	+1	TGFBR2,MAPK8IP1
POSITIVE REGULATION OF SIGNALING RECEPTOR ACTIVITY%GOBP%GO:2000273	positive regulation of signaling receptor activity	0.042789593524606345	0.042789593524606345	+1	FBXW7,TAF1
BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY	BIOCARTA_PYK2_PATHWAY	0.042789593524606345	0.042789593524606345	+1	MAP3K1,MAP2K4
BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY	BIOCARTA_ERK_PATHWAY	0.042789593524606345	0.042789593524606345	+1	EGFR,PDGFRA
HISTONE H3-K4 METHYLATION%GOBP%GO:0051568	histone H3-K4 methylation	0.042789593524606345	0.042789593524606345	+1	KDM6A,TET2
POSITIVE REGULATION OF NITRIC OXIDE METABOLIC PROCESS%GOBP%GO:1904407	positive regulation of nitric oxide metabolic process	0.042789593524606345	0.042789593524606345	+1	AKT1,TLR4
NEGATIVE REGULATION OF SYNAPTIC TRANSMISSION%GOBP%GO:0050805	negative regulation of synaptic transmission	0.042789593524606345	0.042789593524606345	+1	PTEN,LRRK2
POSITIVE REGULATION OF FIBROBLAST PROLIFERATION%GOBP%GO:0048146	positive regulation of fibroblast proliferation	0.042789593524606345	0.042789593524606345	+1	PDGFRA,CDKN1A
FOREBRAIN GENERATION OF NEURONS%GOBP%GO:0021872	forebrain generation of neurons	0.042789593524606345	0.042789593524606345	+1	ERBB4,FGFR2
REGULATION OF CARDIOCYTE DIFFERENTIATION%GOBP%GO:1905207	regulation of cardiocyte differentiation	0.042789593524606345	0.042789593524606345	+1	EGFR,SMAD4
NEGATIVE REGULATION OF DNA REPLICATION%GOBP%GO:0008156	negative regulation of DNA replication	0.042789593524606345	0.042789593524606345	+1	CHEK2,ATR
PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY	PID_IL8_CXCR1_PATHWAY	0.042789593524606345	0.042789593524606345	+1	AKT1,PIK3CG
POSITIVE REGULATION OF PROTEIN IMPORT INTO NUCLEUS%GOBP%GO:0042307	positive regulation of protein import into nucleus	0.042789593524606345	0.042789593524606345	+1	PIK3R1,CDH1
REGULATION OF CYTOKINE-MEDIATED SIGNALING PATHWAY%GOBP%GO:0001959	regulation of cytokine-mediated signaling pathway	0.04380956414192459	0.04380956414192459	+1	RUNX1,CBFB,PTPN11,LIFR
CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 73%1234174	Cellular response to hypoxia	0.04408255124954757	0.04408255124954757	+1	VHL,AJUBA,EP300
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0008543	fibroblast growth factor receptor signaling pathway	0.04408255124954757	0.04408255124954757	+1	FGFR2,FGFR3,PTPN11
POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION%GOBP%GO:0001938	positive regulation of endothelial cell proliferation	0.04408255124954757	0.04408255124954757	+1	NRAS,AKT1,EGR3
MYELOID CELL DIFFERENTIATION%GOBP%GO:0030099	myeloid cell differentiation	0.04480563634815634	0.04480563634815634	+1	CEBPA,TET2,KIT,TGFBR2
P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY	p38 MAPK signaling pathway	0.04544530622846364	0.04544530622846364	+1	MAP3K1,ATM
RESPONSE TO CADMIUM ION%GOBP%GO:0046686	response to cadmium ion	0.04544530622846364	0.04544530622846364	+1	EGFR,AKT1
NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045	Notch signaling pathway	0.04544530622846364	0.04544530622846364	+1	NOTCH1,FBXW7
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.1	Energy dependent regulation of mTOR by LKB1-AMPK	0.04544530622846364	0.04544530622846364	+1	STK11,MTOR
MESODERM MORPHOGENESIS%GOBP%GO:0048332	mesoderm morphogenesis	0.04544530622846364	0.04544530622846364	+1	TBX3,SMAD2
PEPTIDYL-LYSINE TRIMETHYLATION%GOBP%GO:0018023	peptidyl-lysine trimethylation	0.04544530622846364	0.04544530622846364	+1	TET2,SETD2
MYD88-DEPENDENT TOLL-LIKE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0002755	MyD88-dependent toll-like receptor signaling pathway	0.04544530622846364	0.04544530622846364	+1	MAP3K1,TLR4
REGULATION OF BIOMINERAL TISSUE DEVELOPMENT%GOBP%GO:0070167	regulation of biomineral tissue development	0.04544530622846364	0.04544530622846364	+1	NOTCH1,SOX9,ACVR2A
LIMBIC SYSTEM DEVELOPMENT%GOBP%GO:0021761	limbic system development	0.04544530622846364	0.04544530622846364	+1	PTEN,FGFR2
NEGATIVE REGULATION OF CELL ACTIVATION%GOBP%GO:0050866	negative regulation of cell activation	0.046793775194375185	0.046793775194375185	+1	RUNX1,ATM,PDGFRA,CBFB
REGULATION OF TELOMERE MAINTENANCE%GOBP%GO:0032204	regulation of telomere maintenance	0.046937349979753275	0.046937349979753275	+1	ATM,ATRX,ATR
B CELL DIFFERENTIATION%GOBP%GO:0030183	B cell differentiation	0.046937349979753275	0.046937349979753275	+1	FLT3,ATM,KIT
CENTROSOME CYCLE%GOBP%GO:0007098	centrosome cycle	0.046937349979753275	0.046937349979753275	+1	CTNNB1,NPM1,BRCA2
REGULATION OF PHOTORECEPTOR CELL DIFFERENTIATION%GOBP%GO:0046532	regulation of photoreceptor cell differentiation	0.04730869862598764	0.04730869862598764	+1	SOX9
ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 73%114452	Activation of BH3-only proteins	0.04730869862598764	0.04730869862598764	+1	TP53,AKT1
PRO-B CELL DIFFERENTIATION%GOBP%GO:0002328	pro-B cell differentiation	0.04730869862598764	0.04730869862598764	+1	FLT3
EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 73%9630794	Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	0.04730869862598764	0.04730869862598764	+1	CDKN2A
POSITIVE REGULATION OF ANDROGEN RECEPTOR ACTIVITY%GOBP%GO:2000825	positive regulation of androgen receptor activity	0.04730869862598764	0.04730869862598764	+1	TAF1
COMMON-PARTNER SMAD PROTEIN PHOSPHORYLATION%GOBP%GO:0007182	common-partner SMAD protein phosphorylation	0.04730869862598764	0.04730869862598764	+1	SMAD2
METANEPHRIC GLOMERULUS VASCULATURE MORPHOGENESIS%GOBP%GO:0072276	metanephric glomerulus vasculature morphogenesis	0.04730869862598764	0.04730869862598764	+1	PDGFRA
EMBRYONIC SKELETAL LIMB JOINT MORPHOGENESIS%GOBP%GO:0036023	embryonic skeletal limb joint morphogenesis	0.04730869862598764	0.04730869862598764	+1	CTNNB1
MODEL FOR REGULATION OF MSMP EXPRESSION IN CANCER CELLS AND ITS PROANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20200810%WP4397%HOMO SAPIENS	Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors	0.04730869862598764	0.04730869862598764	+1	CTCF
T-CELL RECEPTOR AND CO-STIMULATORY SIGNALING%WIKIPATHWAYS_20200810%WP2583%HOMO SAPIENS	T-Cell Receptor and Co-stimulatory Signaling	0.04730869862598764	0.04730869862598764	+1	PTEN,AKT1
MIRNA TRANSPORT%GOBP%GO:1990428	miRNA transport	0.04730869862598764	0.04730869862598764	+1	TGFBR2
DETECTION OF LIPOPOLYSACCHARIDE%GOBP%GO:0032497	detection of lipopolysaccharide	0.04730869862598764	0.04730869862598764	+1	TLR4
CHONDROCYTE DIFFERENTIATION INVOLVED IN ENDOCHONDRAL BONE MORPHOGENESIS%GOBP%GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	0.04730869862598764	0.04730869862598764	+1	SOX9
GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20200810%WP2533%HOMO SAPIENS	Glycerophospholipid Biosynthetic Pathway	0.04730869862598764	0.04730869862598764	+1	PIK3CA,PIK3CG
VEGF-ACTIVATED PLATELET-DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway	0.04730869862598764	0.04730869862598764	+1	PDGFRA
POSITIVE REGULATION OF APOPTOTIC PROCESS INVOLVED IN MORPHOGENESIS%GOBP%GO:1902339	positive regulation of apoptotic process involved in morphogenesis	0.04730869862598764	0.04730869862598764	+1	NOTCH1
REGULATION OF LATE ENDOSOME TO LYSOSOME TRANSPORT%GOBP%GO:1902822	regulation of late endosome to lysosome transport	0.04730869862598764	0.04730869862598764	+1	LRRK2
EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.3	Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	0.04730869862598764	0.04730869862598764	+1	CDKN2A
EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.3	Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	0.04730869862598764	0.04730869862598764	+1	CDKN2A
REGULATION OF SYNAPTIC VESICLE CLUSTERING%GOBP%GO:2000807	regulation of synaptic vesicle clustering	0.04730869862598764	0.04730869862598764	+1	PTEN
PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY	PID_RETINOIC_ACID_PATHWAY	0.04730869862598764	0.04730869862598764	+1	AKT1,EP300
POSITIVE REGULATION OF EMBRYONIC DEVELOPMENT%GOBP%GO:0040019	positive regulation of embryonic development	0.04730869862598764	0.04730869862598764	+1	GATA3,FOXA2
POSITIVE REGULATION OF RESPONSE TO MACROPHAGE COLONY-STIMULATING FACTOR%GOBP%GO:1903971	positive regulation of response to macrophage colony-stimulating factor	0.04730869862598764	0.04730869862598764	+1	TLR4
HISTONE H3-K27 METHYLATION%GOBP%GO:0070734	histone H3-K27 methylation	0.04730869862598764	0.04730869862598764	+1	EZH2
NEGATIVE REGULATION OF SREBP SIGNALING PATHWAY%GOBP%GO:2000639	negative regulation of SREBP signaling pathway	0.04730869862598764	0.04730869862598764	+1	FBXW7
RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING	Retinoic acid receptors-mediated signaling	0.04730869862598764	0.04730869862598764	+1	AKT1,EP300
REGULATION OF NEURON MATURATION%GOBP%GO:0014041	regulation of neuron maturation	0.04730869862598764	0.04730869862598764	+1	LRRK2
NEGATIVE REGULATION OF MAINTENANCE OF MITOTIC SISTER CHROMATID COHESION%GOBP%GO:0034183	negative regulation of maintenance of mitotic sister chromatid cohesion	0.04730869862598764	0.04730869862598764	+1	ATRX
BRANCHING MORPHOGENESIS OF A NERVE%GOBP%GO:0048755	branching morphogenesis of a nerve	0.04730869862598764	0.04730869862598764	+1	FGFR2
ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS	AlphaE beta7 integrin cell surface interactions	0.04730869862598764	0.04730869862598764	+1	CDH1
POSITIVE REGULATION OF NITRIC OXIDE MEDIATED SIGNAL TRANSDUCTION%GOBP%GO:0010750	positive regulation of nitric oxide mediated signal transduction	0.04730869862598764	0.04730869862598764	+1	EGFR
LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.1	Loss of Function of TGFBR2 in Cancer	0.04730869862598764	0.04730869862598764	+1	TGFBR2
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME DATABASE ID RELEASE 73%202733	Cell surface interactions at the vascular wall	0.04730869862598764	0.04730869862598764	+1	PIK3CA,PIK3R1,NRAS,PTPN11
METANEPHRIC GLOMERULAR CAPILLARY FORMATION%GOBP%GO:0072277	metanephric glomerular capillary formation	0.04730869862598764	0.04730869862598764	+1	PDGFRA
EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 73%9632700	Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	0.04730869862598764	0.04730869862598764	+1	CDKN2A
ENDOCARDIUM FORMATION%GOBP%GO:0060214	endocardium formation	0.04730869862598764	0.04730869862598764	+1	SOX17
REGULATION OF PROTEIN EXPORT FROM NUCLEUS%GOBP%GO:0046825	regulation of protein export from nucleus	0.04730869862598764	0.04730869862598764	+1	TP53,SETD2
POSITIVE REGULATION OF TRANSCRIPTION BY GLUCOSE%GOBP%GO:0046016	positive regulation of transcription by glucose	0.04730869862598764	0.04730869862598764	+1	FOXA2
NEGATIVE REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS%GOBP%GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis	0.04730869862598764	0.04730869862598764	+1	NOTCH1
DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.2	Diseases of Cellular Senescence	0.04730869862598764	0.04730869862598764	+1	CDKN2A
ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-HSA-418990.2	Adherens junctions interactions	0.04730869862598764	0.04730869862598764	+1	CTNNB1,CDH1
REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER BY GLUCOSE%GOBP%GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose	0.04730869862598764	0.04730869862598764	+1	FOXA2
MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 73%8875791	MET activates STAT3	0.04730869862598764	0.04730869862598764	+1	HGF
POSITIVE REGULATION OF T CELL TOLERANCE INDUCTION%GOBP%GO:0002666	positive regulation of T cell tolerance induction	0.04730869862598764	0.04730869862598764	+1	TGFBR2
NR1D1 (REV-ERBA) REPRESSES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 73%1368071	NR1D1 (REV-ERBA) represses gene expression	0.04730869862598764	0.04730869862598764	+1	NCOR1
TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 73%3645790	TGFBR2 Kinase Domain Mutants in Cancer	0.04730869862598764	0.04730869862598764	+1	TGFBR2
REGULATION OF ANDROGEN RECEPTOR ACTIVITY%GOBP%GO:2000823	regulation of androgen receptor activity	0.04730869862598764	0.04730869862598764	+1	TAF1
DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME DATABASE ID RELEASE 73%9675132	Diseases of cellular response to stress	0.04730869862598764	0.04730869862598764	+1	CDKN2A
HISTONE H3-K36 TRIMETHYLATION%GOBP%GO:0097198	histone H3-K36 trimethylation	0.04730869862598764	0.04730869862598764	+1	SETD2
POSITIVE REGULATION OF PROTEIN IMPORT%GOBP%GO:1904591	positive regulation of protein import	0.04730869862598764	0.04730869862598764	+1	PIK3R1,CDH1
NEGATIVE REGULATION OF MESONEPHROS DEVELOPMENT%GOBP%GO:0061218	negative regulation of mesonephros development	0.04730869862598764	0.04730869862598764	+1	GATA3
POSITIVE REGULATION OF CELL PROLIFERATION BY VEGF-ACTIVATED PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	0.04730869862598764	0.04730869862598764	+1	PDGFRA
NEGATIVE REGULATION OF GROWTH RATE%GOBP%GO:0045967	negative regulation of growth rate	0.04730869862598764	0.04730869862598764	+1	NOTCH1
MITRAL VALVE FORMATION%GOBP%GO:0003192	mitral valve formation	0.04730869862598764	0.04730869862598764	+1	NOTCH1
REGULATION OF PEROXIDASE ACTIVITY%GOBP%GO:2000468	regulation of peroxidase activity	0.04730869862598764	0.04730869862598764	+1	LRRK2
NEGATIVE REGULATION OF GLOMERULAR MESANGIAL CELL PROLIFERATION%GOBP%GO:0072125	negative regulation of glomerular mesangial cell proliferation	0.04730869862598764	0.04730869862598764	+1	WT1
PRE-B CELL ALLELIC EXCLUSION%GOBP%GO:0002331	pre-B cell allelic exclusion	0.04730869862598764	0.04730869862598764	+1	ATM
POSITIVE REGULATION OF INTEGRIN BIOSYNTHETIC PROCESS%GOBP%GO:0045726	positive regulation of integrin biosynthetic process	0.04730869862598764	0.04730869862598764	+1	AR
CENTRAL NERVOUS SYSTEM MYELIN MAINTENANCE%GOBP%GO:0032286	central nervous system myelin maintenance	0.04730869862598764	0.04730869862598764	+1	PTEN
POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION INVOLVED IN LUNG MORPHOGENESIS%GOBP%GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	0.04730869862598764	0.04730869862598764	+1	FGFR2
MAST CELL MIGRATION%GOBP%GO:0097531	mast cell migration	0.04730869862598764	0.04730869862598764	+1	KIT
SISTER CHROMATID BIORIENTATION%GOBP%GO:0031134	sister chromatid biorientation	0.04730869862598764	0.04730869862598764	+1	RB1
REGULATION OF CENTRIOLE-CENTRIOLE COHESION%GOBP%GO:0030997	regulation of centriole-centriole cohesion	0.04730869862598764	0.04730869862598764	+1	CTNNB1
REGULATION OF VACUOLAR TRANSPORT%GOBP%GO:1903335	regulation of vacuolar transport	0.04730869862598764	0.04730869862598764	+1	LRRK2
METANEPHRIC S-SHAPED BODY MORPHOGENESIS%GOBP%GO:0072284	metanephric S-shaped body morphogenesis	0.04730869862598764	0.04730869862598764	+1	WT1
LEUKEMIA INHIBITORY FACTOR SIGNALING PATHWAY%GOBP%GO:0048861	leukemia inhibitory factor signaling pathway	0.04730869862598764	0.04730869862598764	+1	LIFR
NEGATIVE REGULATION OF PRO-B CELL DIFFERENTIATION%GOBP%GO:2000974	negative regulation of pro-B cell differentiation	0.04730869862598764	0.04730869862598764	+1	NOTCH1
REGULATION OF PENTOSE-PHOSPHATE SHUNT%GOBP%GO:0043456	regulation of pentose-phosphate shunt	0.04730869862598764	0.04730869862598764	+1	TP53
ERYTHROPOIETIN-MEDIATED SIGNALING PATHWAY%GOBP%GO:0038162	erythropoietin-mediated signaling pathway	0.04730869862598764	0.04730869862598764	+1	KIT
NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	0.04730869862598764	0.04730869862598764	+1	AKT1,AR,BRCA1
NEGATIVE REGULATION OF GLOMERULUS DEVELOPMENT%GOBP%GO:0090194	negative regulation of glomerulus development	0.04730869862598764	0.04730869862598764	+1	WT1
NADPH REGENERATION%GOBP%GO:0006740	NADPH regeneration	0.04730869862598764	0.04730869862598764	+1	IDH1
ACTIVATION OF PROTEIN KINASE B ACTIVITY%GOBP%GO:0032148	activation of protein kinase B activity	0.04730869862598764	0.04730869862598764	+1	AKT1,MTOR
GROWTH INVOLVED IN HEART MORPHOGENESIS%GOBP%GO:0003241	growth involved in heart morphogenesis	0.04730869862598764	0.04730869862598764	+1	NOTCH1
LIMB JOINT MORPHOGENESIS%GOBP%GO:0036022	limb joint morphogenesis	0.04730869862598764	0.04730869862598764	+1	CTNNB1
REGULATION OF CAMKK-AMPK SIGNALING CASCADE%GOBP%GO:1905289	regulation of CAMKK-AMPK signaling cascade	0.04730869862598764	0.04730869862598764	+1	LRRK2
POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER BY GLUCOSE%GOBP%GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	0.04730869862598764	0.04730869862598764	+1	FOXA2
REGULATION OF ENDORIBONUCLEASE ACTIVITY%GOBP%GO:0060699	regulation of endoribonuclease activity	0.04730869862598764	0.04730869862598764	+1	NPM1
N-TERMINAL PEPTIDYL-LYSINE ACETYLATION%GOBP%GO:0018076	N-terminal peptidyl-lysine acetylation	0.04730869862598764	0.04730869862598764	+1	EP300
DOUBLE-STRAND BREAK REPAIR VIA ALTERNATIVE NONHOMOLOGOUS END JOINING%GOBP%GO:0097681	double-strand break repair via alternative nonhomologous end joining	0.04730869862598764	0.04730869862598764	+1	POLQ
REGULATION OF CARDIAC MUSCLE HYPERTROPHY%GOBP%GO:0010611	regulation of cardiac muscle hypertrophy	0.04730869862598764	0.04730869862598764	+1	NOTCH1,SMAD4
LACRIMAL GLAND DEVELOPMENT%GOBP%GO:0032808	lacrimal gland development	0.04730869862598764	0.04730869862598764	+1	FGFR2
POSITIVE REGULATION OF LAMELLIPODIUM ORGANIZATION%GOBP%GO:1902745	positive regulation of lamellipodium organization	0.04730869862598764	0.04730869862598764	+1	PIK3CA,PIK3R1
NEGATIVE REGULATION OF GONAD DEVELOPMENT%GOBP%GO:1905940	negative regulation of gonad development	0.04730869862598764	0.04730869862598764	+1	WT1
RESPONSE TO FOLLICLE-STIMULATING HORMONE%GOBP%GO:0032354	response to follicle-stimulating hormone	0.04730869862598764	0.04730869862598764	+1	NOTCH1
RESPONSE TO NITROSATIVE STRESS%GOBP%GO:0051409	response to nitrosative stress	0.04730869862598764	0.04730869862598764	+1	ATM
POSITIVE REGULATION OF PROTEIN AUTOUBIQUITINATION%GOBP%GO:1902499	positive regulation of protein autoubiquitination	0.04730869862598764	0.04730869862598764	+1	LRRK2
POSITIVE REGULATION OF APOPTOTIC PROCESS INVOLVED IN DEVELOPMENT%GOBP%GO:1904747	positive regulation of apoptotic process involved in development	0.04730869862598764	0.04730869862598764	+1	NOTCH1
POSITIVE REGULATION OF RNA POLYMERASE II REGULATORY REGION SEQUENCE-SPECIFIC DNA BINDING%GOBP%GO:1905636	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding	0.04730869862598764	0.04730869862598764	+1	EP300
NATURAL KILLER CELL CHEMOTAXIS%GOBP%GO:0035747	natural killer cell chemotaxis	0.04730869862598764	0.04730869862598764	+1	PIK3CG
NEGATIVE REGULATION OF PHOTORECEPTOR CELL DIFFERENTIATION%GOBP%GO:0046533	negative regulation of photoreceptor cell differentiation	0.04730869862598764	0.04730869862598764	+1	SOX9
POSITIVE REGULATION OF THYMOCYTE APOPTOTIC PROCESS%GOBP%GO:0070245	positive regulation of thymocyte apoptotic process	0.04730869862598764	0.04730869862598764	+1	TP53
REGULATION OF MITOTIC CELL CYCLE, EMBRYONIC%GOBP%GO:0009794	regulation of mitotic cell cycle, embryonic	0.04730869862598764	0.04730869862598764	+1	CTNNB1
CARDIAC CELL FATE DETERMINATION%GOBP%GO:0060913	cardiac cell fate determination	0.04730869862598764	0.04730869862598764	+1	SOX17
SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCUS ASSEMBLY%GOBP%GO:0035986	senescence-associated heterochromatin focus assembly	0.04730869862598764	0.04730869862598764	+1	CDKN2A
NEGATIVE REGULATION OF MAINTENANCE OF SISTER CHROMATID COHESION%GOBP%GO:0034092	negative regulation of maintenance of sister chromatid cohesion	0.04730869862598764	0.04730869862598764	+1	ATRX
MAST CELL CHEMOTAXIS%GOBP%GO:0002551	mast cell chemotaxis	0.04730869862598764	0.04730869862598764	+1	KIT
MESONEPHRIC TUBULE FORMATION%GOBP%GO:0072172	mesonephric tubule formation	0.04730869862598764	0.04730869862598764	+1	GATA3
CELL MIGRATION INVOLVED IN ENDOCARDIAL CUSHION FORMATION%GOBP%GO:0003273	cell migration involved in endocardial cushion formation	0.04730869862598764	0.04730869862598764	+1	NOTCH1
CANONICAL WNT SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT%GOBP%GO:0061316	canonical Wnt signaling pathway involved in heart development	0.04730869862598764	0.04730869862598764	+1	CTNNB1
NEGATIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	0.04730869862598764	0.04730869862598764	+1	NFE2L2,AKT1,LRRK2
POSITIVE REGULATION OF HEPARAN SULFATE PROTEOGLYCAN BIOSYNTHETIC PROCESS%GOBP%GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	0.04730869862598764	0.04730869862598764	+1	CTNNB1
GROWTH PLATE CARTILAGE CHONDROCYTE DIFFERENTIATION%GOBP%GO:0003418	growth plate cartilage chondrocyte differentiation	0.04730869862598764	0.04730869862598764	+1	SOX9
NEPHRIC DUCT FORMATION%GOBP%GO:0072179	nephric duct formation	0.04730869862598764	0.04730869862598764	+1	GATA3
NEURAL CREST CELL FATE COMMITMENT%GOBP%GO:0014034	neural crest cell fate commitment	0.04730869862598764	0.04730869862598764	+1	SOX9
REGULATION OF BRANCHING MORPHOGENESIS OF A NERVE%GOBP%GO:2000172	regulation of branching morphogenesis of a nerve	0.04730869862598764	0.04730869862598764	+1	LRRK2
NEGATIVE REGULATION OF TRANSCRIPTION INVOLVED IN G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	0.04730869862598764	0.04730869862598764	+1	RB1
REGULATION OF NK T CELL DIFFERENTIATION%GOBP%GO:0051136	regulation of NK T cell differentiation	0.04730869862598764	0.04730869862598764	+1	TGFBR2
NEGATIVE REGULATION OF LYMPHOID PROGENITOR CELL DIFFERENTIATION%GOBP%GO:1905457	negative regulation of lymphoid progenitor cell differentiation	0.04730869862598764	0.04730869862598764	+1	NOTCH1
METANEPHRIC GLOMERULUS MORPHOGENESIS%GOBP%GO:0072275	metanephric glomerulus morphogenesis	0.04730869862598764	0.04730869862598764	+1	PDGFRA
CELLULAR RESPONSE TO ACTINOMYCIN D%GOBP%GO:0072717	cellular response to actinomycin D	0.04730869862598764	0.04730869862598764	+1	TP53
FASCICULATION OF SENSORY NEURON AXON%GOBP%GO:0097155	fasciculation of sensory neuron axon	0.04730869862598764	0.04730869862598764	+1	EPHA3
POSITIVE REGULATION OF MACROPHAGE APOPTOTIC PROCESS%GOBP%GO:2000111	positive regulation of macrophage apoptotic process	0.04730869862598764	0.04730869862598764	+1	CDKN2A
POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN UNFOLDED PROTEIN RESPONSE%GOBP%GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	0.04730869862598764	0.04730869862598764	+1	EP300
LUTEINIZATION%GOBP%GO:0001553	luteinization	0.04730869862598764	0.04730869862598764	+1	PDGFRA
NEGATIVE REGULATION OF TAU-PROTEIN KINASE ACTIVITY%GOBP%GO:1902948	negative regulation of tau-protein kinase activity	0.04730869862598764	0.04730869862598764	+1	RB1
POSITIVE REGULATION OF TRAIL-ACTIVATED APOPTOTIC SIGNALING PATHWAY%GOBP%GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	0.04730869862598764	0.04730869862598764	+1	PTEN
WNT SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT%GOBP%GO:0003306	Wnt signaling pathway involved in heart development	0.04730869862598764	0.04730869862598764	+1	CTNNB1
FIBROBLAST MIGRATION%GOBP%GO:0010761	fibroblast migration	0.04730869862598764	0.04730869862598764	+1	AKT1
REGULATION OF HEPARAN SULFATE PROTEOGLYCAN BIOSYNTHETIC PROCESS%GOBP%GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process	0.04730869862598764	0.04730869862598764	+1	CTNNB1
POSITIVE REGULATION OF CELLULAR RESPONSE TO MACROPHAGE COLONY-STIMULATING FACTOR STIMULUS%GOBP%GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	0.04730869862598764	0.04730869862598764	+1	TLR4
NON-RECOMBINATIONAL REPAIR%GOBP%GO:0000726	non-recombinational repair	0.04760277091250939	0.04760277091250939	+1	ATM,BRCA1,POLQ
REGULATION OF DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	0.04854788549085357	0.04854788549085357	+1	ATM,ATR
SIGNALLING TO ERKS%REACTOME%R-HSA-187687.1	Signalling to ERKs	0.04854788549085357	0.04854788549085357	+1	NRAS,BRAF
RESPONSE TO STARVATION%GOBP%GO:0042594	response to starvation	0.04854788549085357	0.04854788549085357	+1	TP53,MTOR,LRRK2,CDKN1A
NEGATIVE REGULATION OF MICROTUBULE POLYMERIZATION OR DEPOLYMERIZATION%GOBP%GO:0031111	negative regulation of microtubule polymerization or depolymerization	0.04854788549085357	0.04854788549085357	+1	APC,NAV3
REGULATION OF LAMELLIPODIUM ASSEMBLY%GOBP%GO:0010591	regulation of lamellipodium assembly	0.04854788549085357	0.04854788549085357	+1	PIK3CA,PIK3R1
INNER EAR MORPHOGENESIS%GOBP%GO:0042472	inner ear morphogenesis	0.04854788549085357	0.04854788549085357	+1	SOX9,FGFR2
NEGATIVE REGULATION OF OSTEOBLAST DIFFERENTIATION%GOBP%GO:0045668	negative regulation of osteoblast differentiation	0.04854788549085357	0.04854788549085357	+1	NOTCH1,SOX9
POSITIVE REGULATION OF PROTEIN TARGETING TO MITOCHONDRION%GOBP%GO:1903955	positive regulation of protein targeting to mitochondrion	0.04854788549085357	0.04854788549085357	+1	FBXW7,BAP1
SEGMENTATION%GOBP%GO:0035282	segmentation	0.04854788549085357	0.04854788549085357	+1	TBX3,WT1
REGULATION OF MUSCLE HYPERTROPHY%GOBP%GO:0014743	regulation of muscle hypertrophy	0.04854788549085357	0.04854788549085357	+1	NOTCH1,SMAD4
POSITIVE REGULATION OF DNA-TEMPLATED TRANSCRIPTION, INITIATION%GOBP%GO:2000144	positive regulation of DNA-templated transcription, initiation	0.04854788549085357	0.04854788549085357	+1	TP53,CTNNB1
FEMALE GONAD DEVELOPMENT%GOBP%GO:0008585	female gonad development	0.04854788549085357	0.04854788549085357	+1	KIT,PDGFRA
DNA MODIFICATION%GOBP%GO:0006304	DNA modification	0.04891776367583821	0.04891776367583821	+1	DNMT3A,TET2,ATRX
ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20200810%WP2858%HOMO SAPIENS	Ectoderm Differentiation	0.04946301355674577	0.04946301355674577	+1	CTNNB1,FGFR2,SMAD4,FOXA2
RESPONSE TO INSULIN%GOBP%GO:0032868	response to insulin	0.04946301355674577	0.04946301355674577	+1	PIK3CA,APC,PIK3R1,AKT1