Term Overlap P-value Adjusted P-value Old P-value Old Adjusted P-value Odds Ratio Combined Score Genes NR5A1 human 8/22 1.86E-16 1.06E-13 0 0 151.5151515 5488.395484 HSD3B2;STAR;CYP11A1;CYP11B2;CYP11B1;HSD3B1;CYP19A1;CYP17A1 NR5A2 human 5/12 5.02E-11 1.43E-08 0 0 173.6111111 4117.076135 HSD3B2;STAR;CYP11A1;CYP11B1;CYP19A1 NR5A1 mouse 5/23 2.09E-09 3.98E-07 0 0 90.57971014 1810.220371 STAR;CYP11A1;CYP11B2;CYP19A1;CYP17A1 NR4A1 human 4/15 3.91E-08 5.58E-06 0 0 111.1111111 1895.289459 HSD3B2;STAR;CYP11A1;CYP17A1 CREB1 human 6/90 7.39E-08 8.44E-06 0 0 27.77777778 456.1178554 AR;CYP11A1;CYP11B2;CYP11B1;CYP19A1;CYP17A1 NR0B1 human 3/10 1.54E-06 1.46E-04 0 0 125 1673.092298 STAR;CYP19A1;CYP17A1 NR0B1 mouse 3/11 2.11E-06 1.72E-04 0 0 113.6363636 1484.996478 STAR;CYP11A1;CYP19A1 SF1 human 3/12 2.81E-06 2.01E-04 0 0 104.1666667 1331.455379 STAR;HSD3B2;CYP11A1 SF1 mouse 3/15 5.78E-06 3.67E-04 0 0 83.33333333 1005.029762 STAR;CYP11A1;CYP17A1 SP1 human 8/472 1.49E-05 8.53E-04 0 0 7.062146893 78.4727961 AR;STAR;HSD17B1;HSD17B2;HSD3B1;HSD17B11;CYP19A1;CYP17A1 NR2F1 human 2/9 2.01E-04 0.010427214 0 0 92.59259259 788.2250101 CYP19A1;CYP17A1 GATA6 human 2/9 2.01E-04 0.009558279 0 0 92.59259259 788.2250101 CYP11A1;CYP17A1 NR4A1 mouse 2/10 2.51E-04 0.011011909 0 0 83.33333333 690.9348177 AR;HSD3B1 JUN human 4/149 4.46E-04 0.018198668 0 0 11.18568233 86.2946171 AR;STAR;CYP11A1;CYP19A1 GATA4 human 2/19 9.40E-04 0.035769683 0 0 43.85964912 305.7014738 STAR;CYP17A1 ATF1 human 2/24 0.001505088 0.053712822 0 0 34.72222222 225.6563894 CYP11B2;CYP11B1 HDAC1 mouse 2/28 0.002048751 0.068813921 0 0 29.76190476 184.2418179 AR;STAR ATF2 human 2/32 0.00267193 0.084759557 0 0 26.04166667 154.2956829 CYP11B2;CYP11B1 JUN mouse 3/131 0.003830598 0.115119564 0 0 9.541984733 53.09860908 STAR;CYP11A1;CYP19A1 CREBBP mouse 2/41 0.004357042 0.124393545 0 0 20.32520325 110.487031 STAR;CYP11A1 CEBPA human 2/51 0.006672205 0.181420427 0 0 16.33986928 81.85955737 STAR;HSD17B11 WT1 human 2/57 0.008276102 0.214802462 0 0 14.61988304 70.0933218 AR;CYP19A1 RUNX2 mouse 2/57 0.008276102 0.205463225 0 0 14.61988304 70.0933218 CYP11A1;CYP19A1 CEBPB human 2/60 0.009136598 0.217374883 0 0 13.88888889 65.21482257 STAR;CYP19A1 TFAP2A human 2/71 0.012614773 0.288121421 0 0 11.7370892 51.32496092 CYP11A1;HSD17B1 TCF21 mouse 1/6 0.014315529 0.314391031 0 0 69.44444444 294.8896124 AR PIAS1 human 1/6 0.014315529 0.302746919 0 0 69.44444444 294.8896124 CYP17A1 ESR1 human 2/76 0.014358299 0.292806735 0 0 10.96491228 46.52880696 AR;CYP19A1 APEX1 human 1/7 0.01668187 0.328460262 0 0 59.52380952 243.656714 CYP11B2 NCOR1 human 1/7 0.01668187 0.317511587 0 0 59.52380952 243.656714 AR SIN3A mouse 1/7 0.01668187 0.307269278 0 0 59.52380952 243.656714 STAR YY1 human 2/91 0.020167091 0.359856537 0 0 9.157509158 35.74819727 HSD3B2;STAR ESRRA human 1/9 0.021397879 0.370248146 0 0 46.2962963 177.9844204 CYP19A1 SP2 human 1/9 0.021397879 0.359358495 0 0 46.2962963 177.9844204 HSD17B2 NKX3-1 human 1/10 0.023747572 0.387424677 0 0 41.66666667 155.8447908 AR HDAC2 mouse 1/10 0.023747572 0.37666288 0 0 41.66666667 155.8447908 STAR NCOA1 mouse 1/11 0.026091741 0.402659036 0 0 37.87878788 138.1112287 AR SP1 mouse 3/270 0.026936246 0.404752542 0 0 4.62962963 16.73278915 AR;STAR;CYP11A1 SP3 human 2/113 0.030145714 0.441364168 0 0 7.374631268 25.82383871 HSD17B2;CYP17A1 ZEB1 human 1/13 0.030763558 0.439149797 0 0 32.05128205 111.5841172 AR PBX1 mouse 1/13 0.030763558 0.428438826 0 0 32.05128205 111.5841172 CYP17A1 CLOCK human 1/14 0.033091232 0.449883171 0 0 29.76190476 101.4430637 STAR PGR mouse 1/14 0.033091232 0.439420772 0 0 29.76190476 101.4430637 CYP19A1 CEBPD human 1/17 0.04004146 0.519628942 0 0 24.50980392 78.86862428 CYP19A1 ESR2 mouse 1/17 0.04004146 0.508081632 0 0 24.50980392 78.86862428 AR FOXM1 human 1/17 0.04004146 0.497036379 0 0 24.50980392 78.86862428 AR NR5A2 mouse 1/18 0.042347314 0.514474813 0 0 23.14814815 73.19097889 CYP19A1 FOXO3 human 1/18 0.042347314 0.503756587 0 0 23.14814815 73.19097889 AR NR2F2 mouse 1/19 0.044647745 0.520282901 0 0 21.92982456 68.17876067 AR GATA2 human 1/19 0.044647745 0.509877243 0 0 21.92982456 68.17876067 AR RUNX2 human 1/19 0.044647745 0.49987965 0 0 21.92982456 68.17876067 AR STAT3 human 2/142 0.045655782 0.501335605 0 0 5.868544601 18.11399661 AR;CYP19A1 VHL human 1/20 0.046942764 0.505741858 0 0 20.83333333 63.7255458 AR NR1H4 human 1/20 0.046942764 0.496376268 0 0 20.83333333 63.7255458 HSD3B2 PPARGC1A mouse 1/20 0.046942764 0.487351245 0 0 20.83333333 63.7255458 CYP11B2 RXRA human 1/20 0.046942764 0.478648544 0 0 20.83333333 63.7255458 HSD17B2 AHR mouse 1/22 0.051516621 0.516070009 0 0 18.93939394 56.17141644 CYP19A1 CTNNB1 human 1/22 0.051516621 0.50717225 0 0 18.93939394 56.17141644 AR GATA4 mouse 1/22 0.051516621 0.49857611 0 0 18.93939394 56.17141644 STAR E2F4 human 1/23 0.053795482 0.511953674 0 0 18.11594203 52.94503236 AR SOX9 human 1/23 0.053795482 0.503560991 0 0 18.11594203 52.94503236 AR FOXO1 human 1/24 0.056068982 0.516377242 0 0 17.36111111 50.02035618 AR CREM human 1/25 0.058337134 0.528738148 0 0 16.66666667 47.35860747 STAR PGR human 1/25 0.058337134 0.520476614 0 0 16.66666667 47.35860747 CYP19A1 STAT5A mouse 1/25 0.058337134 0.512469282 0 0 16.66666667 47.35860747 AR RARA human 1/26 0.060599948 0.524281369 0 0 16.02564103 44.92726351 HSD17B2 NFIC human 1/27 0.062857438 0.53569548 0 0 15.43209877 42.6988581 CYP17A1 SREBF1 human 1/27 0.062857438 0.527817605 0 0 15.43209877 42.6988581 AR ESR1 mouse 1/29 0.067356494 0.557399391 0 0 14.36781609 38.76086152 CYP19A1 LEF1 human 1/29 0.067356494 0.549436542 0 0 14.36781609 38.76086152 AR YBX1 human 1/30 0.069598084 0.559725436 0 0 13.88888889 37.01414224 AR SMAD3 human 1/31 0.071834399 0.569686689 0 0 13.44086022 35.39505146 CYP17A1 HSF1 human 1/31 0.071834399 0.561882762 0 0 13.44086022 35.39505146 HSD17B6 REST human 1/32 0.07406545 0.571505025 0 0 13.02083333 33.89070469 AR HNF4A mouse 1/36 0.082937262 0.631429025 0 0 11.57407407 28.81563462 SHBG STAT6 human 1/36 0.082937262 0.623120748 0 0 11.57407407 28.81563462 HSD3B2 MYB human 1/37 0.085142178 0.631379007 0 0 11.26126126 27.74135968 DHRS2 NR3C1 human 1/38 0.087341902 0.639387514 0 0 10.96491228 26.73163325 CYP19A1 POU2F1 human 1/38 0.087341902 0.631294002 0 0 10.96491228 26.73163325 AR GATA3 human 1/38 0.087341902 0.623402827 0 0 10.96491228 26.73163325 HSD17B1 HNF4A human 1/45 0.102595623 0.72323581 0 0 9.259259259 21.08296305 SHBG USF2 human 1/47 0.106907786 0.744443242 0 0 8.865248227 19.82082118 CYP19A1 FOS mouse 1/56 0.126062767 0.867251083 0 0 7.44047619 15.40904275 STAR BRCA1 human 1/57 0.128166102 0.871224339 0 0 7.30994152 15.01774986 CYP19A1 FOS human 1/57 0.128166102 0.860974641 0 0 7.30994152 15.01774986 STAR CTNNB1 mouse 1/62 0.138608654 0.920296993 0 0 6.720430108 13.28024702 CYP19A1 USF1 human 1/65 0.144815293 0.950454397 0 0 6.41025641 12.38651402 CYP19A1 HDAC1 human 1/71 0.157097487 1 0 0 5.868544601 10.86202306 AR RELA human 2/301 0.162752455 1 0 0 2.76854928 5.026370189 AR;CYP19A1 NFKB1 human 2/303 0.164446023 1 0 0 2.750275028 4.964721923 AR;CYP19A1 HIF1A human 1/83 0.181145932 1 0 0 5.020080321 8.576567853 AR SP3 mouse 1/83 0.181145932 1 0 0 5.020080321 8.576567853 STAR EGR1 human 1/88 0.190966652 1 0 0 4.734848485 7.839282495 AR AR human 1/93 0.200672014 1 0 0 4.480286738 7.195714485 SRD5A3 RELA mouse 1/121 0.252951544 1 0 0 3.443526171 4.733324156 CYP11A1 E2F1 human 1/134 0.276071429 1 0 0 3.109452736 4.002163082 AR NFKB1 mouse 1/200 0.383061406 1 0 0 2.083333333 1.999083278 CYP11A1