GO.ID	Description	p.Val	FDR	Phenotype	Genes
GO:0060255	regulation of macromolecule metabolic process	2.342834929020885e-30	2.342834929020885e-30	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2
GO:0051171	regulation of nitrogen compound metabolic process	6.442683279472994e-30	6.442683279472994e-30	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0031323	regulation of cellular metabolic process	2.795546905074154e-29	2.795546905074154e-29	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0019222	regulation of metabolic process	3.504914692741367e-29	3.504914692741367e-29	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2
GO:0080090	regulation of primary metabolic process	4.3447021769526397e-29	4.3447021769526397e-29	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0051173	positive regulation of nitrogen compound metabolic process	1.3547326398616152e-28	1.3547326398616152e-28	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,ERCC2,EZH2
GO:0010604	positive regulation of macromolecule metabolic process	1.5086835237673093e-28	1.5086835237673093e-28	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,MAP2K4,STK11,CEBPA,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,ERCC2,EZH2
GO:1903506	regulation of nucleic acid-templated transcription	5.397719420760647e-27	5.397719420760647e-27	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:2001141	regulation of RNA biosynthetic process	5.397719420760647e-27	5.397719420760647e-27	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0009893	positive regulation of metabolic process	6.736362109114156e-27	6.736362109114156e-27	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,ERCC2,EZH2
GO:0097659	nucleic acid-templated transcription	8.268582726275168e-27	8.268582726275168e-27	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0032774	RNA biosynthetic process	8.778566831888679e-27	8.778566831888679e-27	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0019219	regulation of nucleobase-containing compound metabolic process	1.4978157743706098e-26	1.4978157743706098e-26	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,RAD21,ERCC2,EZH2
GO:0031325	positive regulation of cellular metabolic process	2.0820755191749637e-26	2.0820755191749637e-26	+1	TP53,PTEN,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,ATR,SIN3A,VEZF1,CDK12,PTPN11,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,RPL5,SMAD2,AXIN2,ERCC2,EZH2
GO:0006355	regulation of transcription, DNA-templated	2.1065884020216212e-26	2.1065884020216212e-26	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0051252	regulation of RNA metabolic process	3.083059103016402e-26	3.083059103016402e-26	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,RAD21,ERCC2,EZH2
GO:0006351	transcription, DNA-templated	3.719337037370058e-26	3.719337037370058e-26	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0010468	regulation of gene expression	9.240542970881186e-26	9.240542970881186e-26	+1	TP53,PTEN,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2
GO:2000112	regulation of cellular macromolecule biosynthetic process	1.537408381202129e-25	1.537408381202129e-25	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0048522	positive regulation of cellular process	6.4541392846632255e-25	6.4541392846632255e-25	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,CDK12,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2
GO:0010556	regulation of macromolecule biosynthetic process	7.273036221412626e-25	7.273036221412626e-25	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0016070	RNA metabolic process	9.167708459399705e-25	9.167708459399705e-25	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0034654	nucleobase-containing compound biosynthetic process	2.7917969538401177e-24	2.7917969538401177e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0031326	regulation of cellular biosynthetic process	5.9820626416356826e-24	5.9820626416356826e-24	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:1903508	positive regulation of nucleic acid-templated transcription	5.9820626416356826e-24	5.9820626416356826e-24	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMAD2,ERCC2
GO:1902680	positive regulation of RNA biosynthetic process	5.9820626416356826e-24	5.9820626416356826e-24	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMAD2,ERCC2
GO:0045893	positive regulation of transcription, DNA-templated	5.9820626416356826e-24	5.9820626416356826e-24	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMAD2,ERCC2
GO:0090304	nucleic acid metabolic process	5.9820626416356826e-24	5.9820626416356826e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0018130	heterocycle biosynthetic process	6.609040372077175e-24	6.609040372077175e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0019438	aromatic compound biosynthetic process	6.609040372077175e-24	6.609040372077175e-24	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0010628	positive regulation of gene expression	1.0995597234899197e-23	1.0995597234899197e-23	+1	TP53,VHL,KRAS,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,SF3B1,TAF1,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,ERCC2
GO:0048518	positive regulation of biological process	1.1389567474828424e-23	1.1389567474828424e-23	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,CBFB,ATR,SIN3A,VEZF1,CDK12,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2
GO:0009889	regulation of biosynthetic process	1.7774735249535798e-23	1.7774735249535798e-23	+1	TP53,PTEN,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0048523	negative regulation of cellular process	5.248904574665139e-23	5.248904574665139e-23	+1	TP53,PIK3CA,PTEN,APC,VHL,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,CDKN2C,EZH2
GO:0006366	transcription by RNA polymerase II	5.979911923919079e-23	5.979911923919079e-23	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AR,TSHZ2,SOX9,ATM,WT1,HGF,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,KIT,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,CBFB,SIN3A,VEZF1,CDK12,PHF6,NSD1,TBL1XR1,EGR3,ACVR2A,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:1901362	organic cyclic compound biosynthetic process	7.977193488053117e-23	7.977193488053117e-23	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0051254	positive regulation of RNA metabolic process	8.24043256910984e-23	8.24043256910984e-23	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMAD2,ERCC2
GO:0043170	macromolecule metabolic process	1.279133753572786e-22	1.279133753572786e-22	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	1.2827519814933154e-22	1.2827519814933154e-22	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMAD2,ERCC2
GO:0010557	positive regulation of macromolecule biosynthetic process	1.2912483737093306e-22	1.2912483737093306e-22	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,RPL5,SMAD2,ERCC2
GO:0006357	regulation of transcription by RNA polymerase II	1.35892587097115e-22	1.35892587097115e-22	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AR,TSHZ2,SOX9,ATM,WT1,HGF,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,KIT,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,CBFB,SIN3A,VEZF1,CDK12,PHF6,NSD1,TBL1XR1,EGR3,ACVR2A,NCOR1,SMAD2,RAD21,ERCC2,EZH2
GO:0031324	negative regulation of cellular metabolic process	3.3196452024152145e-22	3.3196452024152145e-22	+1	TP53,PIK3CA,PTEN,APC,VHL,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,CRIPAK,CEBPA,AKT1,AR,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0044260	cellular macromolecule metabolic process	3.7511361270479e-22	3.7511361270479e-22	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0048519	negative regulation of biological process	7.06690319933349e-22	7.06690319933349e-22	+1	TP53,PIK3CA,PTEN,APC,VHL,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,HIST1H1C,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,CDKN2C,EZH2
GO:0031328	positive regulation of cellular biosynthetic process	8.758978755077703e-22	8.758978755077703e-22	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,RPL5,SMAD2,ERCC2
GO:0010467	gene expression	8.758978755077703e-22	8.758978755077703e-22	+1	TP53,PTEN,VHL,KRAS,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,BRAF,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2,PCBP1
GO:0006139	nucleobase-containing compound metabolic process	1.1165436294946989e-21	1.1165436294946989e-21	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0034645	cellular macromolecule biosynthetic process	1.8507485765354487e-21	1.8507485765354487e-21	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0009891	positive regulation of biosynthetic process	1.8507485765354487e-21	1.8507485765354487e-21	+1	TP53,VHL,ARID1A,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,HIST1H1C,EP300,FGFR2,SMAD4,FOXA2,BRCA2,NFE2L3,ASXL1,SOX17,TAF1,ATR,SIN3A,VEZF1,CDK12,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,RPL5,SMAD2,ERCC2
GO:0042325	regulation of phosphorylation	1.8507485765354487e-21	1.8507485765354487e-21	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,AXIN2,CDKN2C,EZH2
GO:0009059	macromolecule biosynthetic process	2.0818218422268687e-21	2.0818218422268687e-21	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0044271	cellular nitrogen compound biosynthetic process	3.3519417249319882e-21	3.3519417249319882e-21	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0031399	regulation of protein modification process	7.158963812179882e-21	7.158963812179882e-21	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,RPL5,AXIN2,CDKN2C,EZH2
GO:0009892	negative regulation of metabolic process	7.551853270071073e-21	7.551853270071073e-21	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,RPL22,STK11,CRIPAK,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,MTOR,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,CDKN2C,EZH2
GO:0046483	heterocycle metabolic process	1.1376108157989092e-20	1.1376108157989092e-20	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0016310	phosphorylation	1.2859722166063326e-20	1.2859722166063326e-20	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0006725	cellular aromatic compound metabolic process	1.506372195169468e-20	1.506372195169468e-20	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0043412	macromolecule modification	1.7924161381657106e-20	1.7924161381657106e-20	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0036211	protein modification process	1.9065920836807347e-20	1.9065920836807347e-20	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0006464	cellular protein modification process	1.9065920836807347e-20	1.9065920836807347e-20	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,CDKN2C,EZH2
GO:0006468	protein phosphorylation	3.2906957963096814e-20	3.2906957963096814e-20	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0051338	regulation of transferase activity	3.7793499461217245e-20	3.7793499461217245e-20	+1	TP53,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,CDKN1B,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,EIF4A2,CDK12,MAPK8IP1,RPL5,CDKN2C,EZH2
GO:0019220	regulation of phosphate metabolic process	1.3311996482846817e-19	1.3311996482846817e-19	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,AXIN2,CDKN2C,EZH2
GO:0051174	regulation of phosphorus metabolic process	1.3496205126848213e-19	1.3496205126848213e-19	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,AXIN2,CDKN2C,EZH2
GO:1901360	organic cyclic compound metabolic process	2.691328663394614e-19	2.691328663394614e-19	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0051726	regulation of cell cycle	2.7197715147226774e-19	2.7197715147226774e-19	+1	TP53,PTEN,APC,EGFR,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,CTCF,BAP1,NPM1,TBX3,MAP2K4,STK11,CEBPA,AKT1,STAG2,SOX9,ATM,CDKN1B,MTOR,ATRX,BRCA1,FOXA1,CHEK2,SETD2,EP300,FGFR2,CCND1,CDKN1A,TAF1,PPP2R1A,ATR,SMC1A,MECOM,SMC3,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0051172	negative regulation of nitrogen compound metabolic process	3.359027340789083e-19	3.359027340789083e-19	+1	TP53,PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,CRIPAK,CEBPA,AKT1,AR,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,SIN3A,EIF4A2,PHF6,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0001932	regulation of protein phosphorylation	3.5182011997954098e-19	3.5182011997954098e-19	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,AXIN2,CDKN2C,EZH2
GO:0043549	regulation of kinase activity	3.5251758445695274e-19	3.5251758445695274e-19	+1	PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,CDKN1B,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0008283	cell population proliferation	3.9898135042058804e-19	3.9898135042058804e-19	+1	TP53,PTEN,APC,VHL,KRAS,PBRM1,EGFR,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,CTCF,BAP1,NPM1,RUNX1,NRAS,TBX3,STK11,CEBPA,AKT1,AR,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,ERBB4,TLR4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,BRCA2,FGFR3,TGFBR2,CDKN1A,MAPK8IP1,EGR3,MECOM,LIFR,AXIN2,CDKN2C,EZH2
GO:0010605	negative regulation of macromolecule metabolic process	5.780583021496995e-19	5.780583021496995e-19	+1	TP53,PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,RPL22,CRIPAK,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,TLR4,ARID5B,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,EIF4A2,PHF6,MAPK8IP1,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0048583	regulation of response to stimulus	8.84770646075365e-19	8.84770646075365e-19	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0042127	regulation of cell population proliferation	1.1318014600400286e-18	1.1318014600400286e-18	+1	TP53,PTEN,APC,VHL,KRAS,PBRM1,EGFR,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,FLT3,CTCF,BAP1,NPM1,NRAS,TBX3,STK11,CEBPA,AKT1,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,ERBB4,TLR4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,BRCA2,FGFR3,TGFBR2,CDKN1A,MAPK8IP1,EGR3,LIFR,AXIN2,CDKN2C,EZH2
GO:0007049	cell cycle	1.3787943777968443e-18	1.3787943777968443e-18	+1	TP53,PTEN,APC,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,CTCF,BAP1,NPM1,TBX3,MAP2K4,STK11,CEBPA,AKT1,STAG2,AJUBA,SOX9,ATM,CDKN1B,HGF,MTOR,ATRX,BRCA1,FOXA1,CHEK2,SETD2,EP300,FGFR2,CCND1,BRCA2,CDKN1A,TAF1,PPP2R1A,ATR,SMC1A,ACVR1B,MECOM,SMC3,NCOR1,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0071704	organic substance metabolic process	1.756725008063574e-18	1.756725008063574e-18	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0006807	nitrogen compound metabolic process	3.069657639490125e-18	3.069657639490125e-18	+1	TP53,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0034641	cellular nitrogen compound metabolic process	4.0604350679801465e-18	4.0604350679801465e-18	+1	TP53,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2,PCBP1
GO:0044238	primary metabolic process	4.7249970300966095e-18	4.7249970300966095e-18	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0044237	cellular metabolic process	7.33331344346562e-18	7.33331344346562e-18	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0051246	regulation of protein metabolic process	2.7074773615222457e-17	2.7074773615222457e-17	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,RPL5,SPOP,AXIN2,CDKN2C,EZH2
GO:0044249	cellular biosynthetic process	4.100577103635056e-17	4.100577103635056e-17	+1	TP53,PIK3CA,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	7.047567660553681e-17	7.047567660553681e-17	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,ATM,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,POLQ,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:1903507	negative regulation of nucleic acid-templated transcription	9.842330992554799e-17	9.842330992554799e-17	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:1902679	negative regulation of RNA biosynthetic process	1.0060364278351183e-16	1.0060364278351183e-16	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0045944	positive regulation of transcription by RNA polymerase II	1.0792466916883822e-16	1.0792466916883822e-16	+1	TP53,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,CTCF,NFE2L2,NPM1,RUNX1,TBX3,CEBPA,AR,SOX9,ATM,WT1,HGF,TLR4,TET2,ATRX,BRCA1,FOXA1,EP300,FGFR2,SMAD4,FOXA2,ASXL1,SOX17,TAF1,SIN3A,VEZF1,CDK12,TBL1XR1,EGR3,ACVR2A,SMAD2,ERCC2
GO:1901576	organic substance biosynthetic process	1.1300060202266222e-16	1.1300060202266222e-16	+1	TP53,PIK3CA,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0032268	regulation of cellular protein metabolic process	2.098235968271777e-16	2.098235968271777e-16	+1	TP53,PTEN,APC,KRAS,EGFR,NF1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,CDK12,PTPN11,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,RPL5,AXIN2,CDKN2C,EZH2
GO:0051253	negative regulation of RNA metabolic process	2.1685570807182195e-16	2.1685570807182195e-16	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0008152	metabolic process	2.89440023771495e-16	2.89440023771495e-16	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,U2AF1,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,IDH2,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,B4GALT3,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,HIST1H2BD,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2,PCBP1
GO:0009058	biosynthetic process	3.0906230974605524e-16	3.0906230974605524e-16	+1	TP53,PIK3CA,PTEN,VHL,ARID1A,PBRM1,EGFR,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,KEAP1,CDH1,CTCF,NFE2L2,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,ASXL1,SOX17,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,ACVR1B,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,SMC3,NCOR1,RPL5,SMAD2,RAD21,ERCC2,EZH2
GO:0010646	regulation of cell communication	3.1663987076831214e-16	3.1663987076831214e-16	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,ARHGAP35,NFE2L2,RUNX1,MAP2K4,STK11,CRIPAK,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0009966	regulation of signal transduction	4.228353976941971e-16	4.228353976941971e-16	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,ARHGAP35,NFE2L2,RUNX1,MAP2K4,STK11,CRIPAK,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0045892	negative regulation of transcription, DNA-templated	5.774162438577921e-16	5.774162438577921e-16	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0023051	regulation of signaling	6.715920570165278e-16	6.715920570165278e-16	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,ARHGAP35,NFE2L2,RUNX1,MAP2K4,STK11,CRIPAK,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,FGFR3,ASXL1,TGFBR2,SOX17,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0051128	regulation of cellular component organization	8.082990431053913e-16	8.082990431053913e-16	+1	TP53,PTEN,APC,NAV3,EGFR,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,STK11,CRIPAK,EPHA3,AKT1,STAG2,AR,AJUBA,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,KIT,HIST1H1C,PDGFRA,EP300,SMAD4,SOX17,CDKN1A,PPP2R1A,CBFB,ATR,SIN3A,SMC1A,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,SMC3,AXIN2,RAD21,ERCC2,CDKN2C
GO:0044267	cellular protein metabolic process	9.5084549533715e-16	9.5084549533715e-16	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,EIF4A2,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:0010629	negative regulation of gene expression	1.003096568714721e-15	1.003096568714721e-15	+1	TP53,VHL,EGFR,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,NPM1,RUNX1,TBX3,RPL22,CEBPA,AKT1,AR,AJUBA,SOX9,ATM,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,LRRK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,PPP2R1A,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0051276	chromosome organization	2.1489105996835267e-15	2.1489105996835267e-15	+1	TP53,APC,ARID1A,PBRM1,CDKN2A,RB1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,KDM6A,STAG2,SOX9,ATM,KDM5C,TET2,ATRX,BRCA1,FOXA1,HIST1H1C,SETD2,EP300,SMAD4,BRCA2,ASXL1,ATR,SIN3A,HIST1H2BD,SMC1A,NSD1,TBL1XR1,MECOM,SMC3,AXIN2,RAD21,ERCC2,EZH2
GO:0031327	negative regulation of cellular biosynthetic process	4.7696787816261666e-15	4.7696787816261666e-15	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,ATR,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0050794	regulation of cellular process	5.4977406080222e-15	5.4977406080222e-15	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,STAG2,BRAF,AR,AJUBA,EPPK1,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,SMC3,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2
GO:0009890	negative regulation of biosynthetic process	7.743119498193701e-15	7.743119498193701e-15	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,ATR,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0010558	negative regulation of macromolecule biosynthetic process	8.200959022782622e-15	8.200959022782622e-15	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,ATR,SIN3A,EIF4A2,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0048513	animal organ development	1.20589483276681e-14	1.20589483276681e-14	+1	TP53,PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,ARHGAP35,RUNX1,TBX3,CEBPA,EPHA3,AKT1,BRAF,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,SIN3A,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,EZH2
GO:0065009	regulation of molecular function	1.2668375912824599e-14	1.2668375912824599e-14	+1	TP53,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CTCF,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,CDKN1B,HGF,ERBB4,MTOR,TLR4,ARID5B,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,CDK12,MAPK8IP1,NSD1,RPL5,SMAD2,CDKN2C,EZH2
GO:0050789	regulation of biological process	1.5014094475879627e-14	1.5014094475879627e-14	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,DNMT3A,MAP3K1,FLT3,TSHZ3,KEAP1,CDH1,ARHGAP35,CTCF,NFE2L2,BAP1,NPM1,RUNX1,NRAS,TBX3,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,EPHA3,AKT1,STAG2,BRAF,AR,AJUBA,EPPK1,TSHZ2,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,NFE2L3,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,EIF4A2,CDK12,PHF6,SMC1A,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,SMC3,NCOR1,RPL5,SMAD2,SPOP,AXIN2,MIR142,RAD21,ERCC2,CDKN2C,EZH2
GO:2000113	negative regulation of cellular macromolecule biosynthetic process	1.9677918102564218e-14	1.9677918102564218e-14	+1	TP53,VHL,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,TSHZ3,CTCF,BAP1,RUNX1,TBX3,CEBPA,AR,SOX9,CDKN1B,WT1,KDM5C,ARID5B,ATRX,ELF3,BRCA1,CHEK2,HIST1H1C,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,ATR,SIN3A,PHF6,NSD1,TBL1XR1,MECOM,NCOR1,SMAD2,EZH2
GO:0045859	regulation of protein kinase activity	2.084615777588114e-14	2.084615777588114e-14	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,AKT1,BRAF,PIK3CG,CDKN1B,MTOR,TLR4,LRRK2,KIT,CCND1,TGFBR2,CDKN1A,PPP2R1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0018193	peptidyl-amino acid modification	3.964110357403335e-14	3.964110357403335e-14	+1	TP53,PTEN,EGFR,CDKN2A,FBXW7,CTNNB1,FLT3,KDM6A,EPHA3,AKT1,BRAF,ATM,HGF,ERBB4,MTOR,TET2,ATRX,BRCA1,LRRK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,BRCA2,FGFR3,TGFBR2,TAF1,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,NSD1,EZH2
GO:0010564	regulation of cell cycle process	3.9757596458125344e-14	3.9757596458125344e-14	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,FBXW7,CTNNB1,CTCF,NPM1,AKT1,STAG2,SOX9,ATM,CDKN1B,ATRX,BRCA1,CHEK2,SETD2,EP300,CCND1,CDKN1A,TAF1,PPP2R1A,SMC1A,SMC3,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0007275	multicellular organism development	7.181875785965026e-14	7.181875785965026e-14	+1	TP53,PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0051247	positive regulation of protein metabolic process	7.397895905444899e-14	7.397895905444899e-14	+1	TP53,PTEN,APC,KRAS,EGFR,CDKN2A,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,NPM1,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,CDKN1B,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PTPN11,MAPK8IP1,ACVR2A,RPL5,AXIN2,EZH2
GO:0040007	growth	8.233027783449204e-14	8.233027783449204e-14	+1	TP53,PTEN,EGFR,CDKN2A,RB1,NOTCH1,CTNNB1,BAP1,STK11,AKT1,EPPK1,SOX9,CDKN1B,WT1,ERBB4,MTOR,FGFR2,SMAD4,USP9X,FGFR3,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,H3F3C,CDKN2C
GO:0070887	cellular response to chemical stimulus	8.750664409628302e-14	8.750664409628302e-14	+1	TP53,PIK3CA,APC,VHL,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CDH1,NFE2L2,NPM1,RUNX1,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,TGFBR2,CDKN1A,TAF1,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2
GO:0006796	phosphate-containing compound metabolic process	9.07550695258168e-14	9.07550695258168e-14	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0050793	regulation of developmental process	9.519892068597969e-14	9.519892068597969e-14	+1	PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,AR,EPPK1,SOX9,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0071495	cellular response to endogenous stimulus	1.0367987626369535e-13	1.0367987626369535e-13	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,CDH1,RUNX1,STK11,CRIPAK,AKT1,AR,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,FOXA1,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,TAF1,CBFB,SMC1A,PTPN11,EGR3,ACVR2A,NCOR1,SMAD2
GO:0019538	protein metabolic process	1.3529762490403156e-13	1.3529762490403156e-13	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,EIF4A2,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:0006793	phosphorus metabolic process	1.3529762490403156e-13	1.3529762490403156e-13	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,ACVR2A,MECOM,NCOR1,SMAD2,AXIN2,CDKN2C,EZH2
GO:0048869	cellular developmental process	1.5309088950790547e-13	1.5309088950790547e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,NPM1,RUNX1,TBX3,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ELF3,LRRK2,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0006915	apoptotic process	1.5521596391474243e-13	1.5521596391474243e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,ERCC2
GO:0016043	cellular component organization	1.6100157716171766e-13	1.6100157716171766e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,IDH1,STK11,CRIPAK,KDM6A,EPHA3,AKT1,STAG2,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,SMAD4,USP9X,BRCA2,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,SMC1A,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0045595	regulation of cell differentiation	1.7685361378346656e-13	1.7685361378346656e-13	+1	PTEN,APC,VHL,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,AR,SOX9,HGF,MTOR,TLR4,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,ASXL1,TGFBR2,PPP2R1A,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0012501	programmed cell death	1.7876969831193506e-13	1.7876969831193506e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,MECOM,ERCC2
GO:0040008	regulation of growth	1.8951878324441368e-13	1.8951878324441368e-13	+1	TP53,PTEN,EGFR,CDKN2A,RB1,NOTCH1,BAP1,STK11,AKT1,EPPK1,CDKN1B,WT1,ERBB4,MTOR,FGFR2,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,H3F3C,CDKN2C
GO:0048584	positive regulation of response to stimulus	1.9496335107459264e-13	1.9496335107459264e-13	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,MAP3K1,FLT3,NFE2L2,RUNX1,NRAS,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,ELF3,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,TAF1,CBFB,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0032270	positive regulation of cellular protein metabolic process	2.0882551404498576e-13	2.0882551404498576e-13	+1	TP53,PTEN,KRAS,EGFR,CDKN2A,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,NPM1,MAP2K4,STK11,CEBPA,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PTPN11,MAPK8IP1,ACVR2A,RPL5,AXIN2,EZH2
GO:0010033	response to organic substance	2.508413491197009e-13	2.508413491197009e-13	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,FLT3,CDH1,NFE2L2,NPM1,RUNX1,STK11,CRIPAK,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2,MIR142
GO:0009719	response to endogenous stimulus	2.98622034144714e-13	2.98622034144714e-13	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,CDH1,RUNX1,STK11,CRIPAK,AKT1,AR,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,FOXA1,EP300,FGFR2,CCND1,SMAD4,USP9X,FGFR3,TGFBR2,TAF1,CBFB,SMC1A,PTPN11,EGR3,ACVR2A,NCOR1,SMAD2
GO:0008285	negative regulation of cell population proliferation	3.7449933282593223e-13	3.7449933282593223e-13	+1	TP53,PTEN,APC,VHL,PBRM1,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,CTCF,BAP1,NPM1,STK11,CEBPA,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,ERBB4,BRCA2,CDKN1A,AXIN2,CDKN2C
GO:0008219	cell death	3.9680253387305105e-13	3.9680253387305105e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,STK11,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,CHEK2,EP300,FGFR2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,ACVR1B,EGR3,MECOM,AXIN2,ERCC2
GO:0048731	system development	3.980985722038369e-13	3.980985722038369e-13	+1	TP53,PIK3CA,PTEN,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,SIN3A,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0006950	response to stress	8.572150320339809e-13	8.572150320339809e-13	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,MAP3K1,KEAP1,ARHGAP35,NFE2L2,NPM1,NRAS,TBX3,MAP2K4,STK11,CEBPA,AKT1,BRAF,AJUBA,EPPK1,PIK3CG,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,POLQ,CHEK2,KIT,SETD2,PDGFRA,EP300,CCND1,SMAD4,FOXA2,BRCA2,CDKN1A,TAF1,ATR,SIN3A,VEZF1,SMC1A,PTPN11,MAPK8IP1,MECOM,NCOR1,AXIN2,MIR142,RAD21,ERCC2
GO:0071840	cellular component organization or biogenesis	1.0137090004634412e-12	1.0137090004634412e-12	+1	TP53,PIK3CA,PTEN,APC,VHL,ARID1A,PBRM1,NAV3,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,ARHGAP35,CTCF,BAP1,NPM1,RUNX1,IDH1,STK11,CRIPAK,KDM6A,EPHA3,AKT1,STAG2,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,FGFR2,SMAD4,USP9X,BRCA2,ASXL1,SOX17,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,SMC1A,PTPN11,ACVR1B,MAPK8IP1,H3F3C,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0006325	chromatin organization	1.1797367106092191e-12	1.1797367106092191e-12	+1	TP53,ARID1A,PBRM1,CDKN2A,RB1,CTNNB1,CTCF,BAP1,NPM1,KDM6A,SOX9,KDM5C,TET2,ATRX,BRCA1,FOXA1,HIST1H1C,SETD2,EP300,SMAD4,BRCA2,ASXL1,SIN3A,HIST1H2BD,NSD1,TBL1XR1,MECOM,EZH2
GO:0042327	positive regulation of phosphorylation	1.194304194999915e-12	1.194304194999915e-12	+1	TP53,KRAS,EGFR,NOTCH1,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,MAPK8IP1,ACVR2A,AXIN2,EZH2
GO:0031401	positive regulation of protein modification process	1.194304194999915e-12	1.194304194999915e-12	+1	TP53,PTEN,KRAS,EGFR,CDKN2A,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,MAPK8IP1,ACVR2A,AXIN2,EZH2
GO:0022402	cell cycle process	1.3300326757760465e-12	1.3300326757760465e-12	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,CTCF,NPM1,STK11,AKT1,STAG2,AJUBA,SOX9,ATM,CDKN1B,MTOR,ATRX,BRCA1,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,TAF1,PPP2R1A,SMC1A,ACVR1B,SMC3,NCOR1,AXIN2,RAD21,ERCC2,CDKN2C,EZH2
GO:0071900	regulation of protein serine/threonine kinase activity	1.4995734076839553e-12	1.4995734076839553e-12	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,FLT3,MAP2K4,CEBPA,AKT1,BRAF,PIK3CG,CDKN1B,TLR4,LRRK2,KIT,CCND1,CDKN1A,PPP2R1A,CDK12,MAPK8IP1,CDKN2C,EZH2
GO:0071310	cellular response to organic substance	1.5866400427709526e-12	1.5866400427709526e-12	+1	TP53,PIK3CA,APC,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,FLT3,CDH1,NFE2L2,NPM1,RUNX1,STK11,CRIPAK,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,TGFBR2,CDKN1A,TAF1,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2
GO:0032502	developmental process	2.9482934860891758e-12	2.9482934860891758e-12	+1	TP53,PIK3CA,PTEN,APC,VHL,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,NPM1,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,AR,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0042221	response to chemical	3.1485198610971646e-12	3.1485198610971646e-12	+1	TP53,PIK3CA,APC,VHL,ARID1A,EGFR,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,KEAP1,CDH1,ARHGAP35,NFE2L2,NPM1,RUNX1,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,CDKN1A,TAF1,PPP2R1A,CBFB,PTPN11,ACVR1B,EGR3,ACVR2A,LIFR,NCOR1,SMAD2,MIR142
GO:0048856	anatomical structure development	3.1546006777944276e-12	3.1546006777944276e-12	+1	TP53,PIK3CA,PTEN,APC,VHL,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,EPPK1,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:1902531	regulation of intracellular signal transduction	3.1546006777944276e-12	3.1546006777944276e-12	+1	TP53,PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,ARHGAP35,NFE2L2,MAP2K4,STK11,AKT1,BRAF,AJUBA,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,BRCA1,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,TAF1,PPP2R1A,ATR,CDK12,PTPN11,MAPK8IP1,MECOM,NCOR1,RPL5,EZH2
GO:0016049	cell growth	3.97464606102854e-12	3.97464606102854e-12	+1	TP53,EGFR,CDKN2A,RB1,CTNNB1,BAP1,STK11,AKT1,SOX9,CDKN1B,WT1,MTOR,SMAD4,USP9X,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,H3F3C,CDKN2C
GO:0048732	gland development	4.253952235382064e-12	4.253952235382064e-12	+1	NF1,GATA3,FBXW7,ARHGAP35,TBX3,CEBPA,AKT1,SOX9,WT1,HGF,ERBB4,ARID5B,ELF3,FGFR2,BRCA2
GO:0010562	positive regulation of phosphorus metabolic process	4.696561182313693e-12	4.696561182313693e-12	+1	TP53,KRAS,EGFR,NOTCH1,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,MAPK8IP1,ACVR2A,AXIN2,EZH2
GO:0045937	positive regulation of phosphate metabolic process	4.696561182313693e-12	4.696561182313693e-12	+1	TP53,KRAS,EGFR,NOTCH1,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,MAPK8IP1,ACVR2A,AXIN2,EZH2
GO:0009967	positive regulation of signal transduction	5.621156660126735e-12	5.621156660126735e-12	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,TAF1,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,EZH2
GO:0001934	positive regulation of protein phosphorylation	5.621156660126735e-12	5.621156660126735e-12	+1	TP53,KRAS,EGFR,NOTCH1,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,SMAD4,FGFR3,TGFBR2,CDKN1A,PTPN11,MAPK8IP1,ACVR2A,AXIN2,EZH2
GO:0048585	negative regulation of response to stimulus	5.713649097309084e-12	5.713649097309084e-12	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,CRIPAK,AKT1,AR,AJUBA,EPPK1,SOX9,ATM,CDKN1B,HGF,TLR4,BRCA1,LRRK2,POLQ,PDGFRA,SMAD4,FOXA2,ASXL1,TGFBR2,SOX17,CDKN1A,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0046777	protein autophosphorylation	5.97288139820339e-12	5.97288139820339e-12	+1	EGFR,FLT3,STK11,AKT1,ATM,ERBB4,MTOR,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,FGFR3,TAF1,ATR,CDK12,ACVR1B
GO:0048762	mesenchymal cell differentiation	8.093249039094084e-12	8.093249039094084e-12	+1	PTEN,NOTCH1,CTNNB1,EPHA3,SOX9,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0035556	intracellular signal transduction	8.128453725743776e-12	8.128453725743776e-12	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,ARHGAP35,NFE2L2,NRAS,MAP2K4,STK11,AKT1,BRAF,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,BRCA1,LRRK2,CHEK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,PTPN11,MAPK8IP1,MECOM,NCOR1,RPL5,SMAD2,EZH2
GO:0060485	mesenchyme development	8.733360784424664e-12	8.733360784424664e-12	+1	PTEN,NOTCH1,CTNNB1,EPHA3,SOX9,WT1,HGF,ERBB4,MTOR,FOXA1,FGFR2,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0010647	positive regulation of cell communication	9.314737559391062e-12	9.314737559391062e-12	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,TSHZ3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,TAF1,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,EZH2
GO:0080134	regulation of response to stress	1.0215240358175396e-11	1.0215240358175396e-11	+1	PTEN,KRAS,EGFR,PIK3R1,CDKN2A,GATA3,RB1,FBXW7,MAP3K1,NFE2L2,NPM1,NRAS,MAP2K4,CEBPA,AKT1,AJUBA,EPPK1,ATM,CDKN1B,HGF,MTOR,TLR4,BRCA1,LRRK2,POLQ,SETD2,PDGFRA,EP300,FOXA2,CDKN1A,ATR,SIN3A,PTPN11,MAPK8IP1,MECOM,NCOR1,AXIN2,MIR142
GO:0000122	negative regulation of transcription by RNA polymerase II	1.05782661938258e-11	1.05782661938258e-11	+1	TP53,VHL,RB1,NOTCH1,DNMT3A,CTCF,RUNX1,TBX3,AR,SOX9,WT1,ARID5B,ATRX,EP300,FGFR2,CCND1,SMAD4,USP9X,TAF1,CBFB,SIN3A,PHF6,NSD1,TBL1XR1,NCOR1,SMAD2,EZH2
GO:0023056	positive regulation of signaling	1.05782661938258e-11	1.05782661938258e-11	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,TSHZ3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,ASXL1,TAF1,ATR,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,SMAD2,AXIN2,EZH2
GO:0030154	cell differentiation	1.05782661938258e-11	1.05782661938258e-11	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,ARHGAP35,RUNX1,TBX3,CEBPA,EPHA3,AKT1,AR,SOX9,ATM,WT1,HGF,ERBB4,MTOR,TLR4,TET2,ELF3,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,PPP2R1A,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0001837	epithelial to mesenchymal transition	1.233253037815867e-11	1.233253037815867e-11	+1	PTEN,NOTCH1,CTNNB1,EPHA3,SOX9,HGF,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:1902806	regulation of cell cycle G1/S phase transition	1.2932935654698503e-11	1.2932935654698503e-11	+1	TP53,PTEN,EGFR,CDKN2A,RB1,FBXW7,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,TAF1,CDKN2C,EZH2
GO:0050790	regulation of catalytic activity	2.154235005902213e-11	2.154235005902213e-11	+1	TP53,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,RB1,NOTCH1,FBXW7,MAP3K1,FLT3,NPM1,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,PIK3CG,CDKN1B,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FOXA2,FGFR3,TGFBR2,CDKN1A,PPP2R1A,EIF4A2,CDK12,MAPK8IP1,RPL5,CDKN2C,EZH2
GO:0010717	regulation of epithelial to mesenchymal transition	3.310795689784074e-11	3.310795689784074e-11	+1	PTEN,NOTCH1,CTNNB1,EPHA3,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
GO:0009888	tissue development	3.358851919739279e-11	3.358851919739279e-11	+1	TP53,PTEN,NF1,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,EPPK1,SOX9,CDKN1B,WT1,HGF,ERBB4,MTOR,ARID5B,ELF3,FOXA1,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,BRCA2,FGFR3,TGFBR2,SOX17,CDKN1A,CBFB,VEZF1,ACVR2A,SMAD2,AXIN2,ERCC2,EZH2
GO:0033554	cellular response to stress	3.774697474674984e-11	3.774697474674984e-11	+1	TP53,APC,VHL,EGFR,PIK3R1,CDKN2A,NOTCH1,FBXW7,MAP3K1,KEAP1,NFE2L2,NPM1,TBX3,MAP2K4,STK11,AKT1,BRAF,AJUBA,ATM,CDKN1B,HGF,MTOR,TLR4,ATRX,BRCA1,LRRK2,POLQ,CHEK2,SETD2,PDGFRA,EP300,CCND1,BRCA2,CDKN1A,TAF1,ATR,SMC1A,MAPK8IP1,MECOM,NCOR1,AXIN2,RAD21,ERCC2
GO:0031400	negative regulation of protein modification process	3.967691754578262e-11	3.967691754578262e-11	+1	PTEN,APC,NF1,CDKN2A,RB1,CTNNB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,TLR4,BRCA1,LRRK2,SMAD4,CDKN1A,TAF1,PPP2R1A,SIN3A,MAPK8IP1,MECOM,NCOR1,RPL5
GO:0051348	negative regulation of transferase activity	4.1443554747925224e-11	4.1443554747925224e-11	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,EIF4A2,MAPK8IP1,RPL5
GO:0023014	signal transduction by protein phosphorylation	5.2867969557192994e-11	5.2867969557192994e-11	+1	PTEN,KRAS,EGFR,NF1,NOTCH1,FBXW7,MAP3K1,FLT3,NRAS,MAP2K4,BRAF,PIK3CG,SOX9,HGF,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PPP2R1A,CDK12,PTPN11,MAPK8IP1,MECOM,NCOR1,EZH2
GO:0051716	cellular response to stimulus	5.82929659566793e-11	5.82929659566793e-11	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,CDK12,SMC1A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,RAD21,ERCC2,EZH2
GO:0009968	negative regulation of signal transduction	8.277455059562772e-11	8.277455059562772e-11	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,CRIPAK,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,TGFBR2,SOX17,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0007062	sister chromatid cohesion	1.0441660936972977e-10	1.0441660936972977e-10	+1	RB1,FBXW7,CTNNB1,CTCF,STAG2,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0042326	negative regulation of phosphorylation	1.4595489820430068e-10	1.4595489820430068e-10	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,TLR4,LRRK2,SMAD4,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,MECOM,NCOR1,CDKN2C
GO:0000165	MAPK cascade	1.5140829514389456e-10	1.5140829514389456e-10	+1	PTEN,KRAS,EGFR,NF1,NOTCH1,FBXW7,FLT3,NRAS,MAP2K4,BRAF,PIK3CG,SOX9,HGF,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PPP2R1A,CDK12,PTPN11,MAPK8IP1,MECOM,NCOR1,EZH2
GO:0006996	organelle organization	1.604683827657519e-10	1.604683827657519e-10	+1	TP53,PTEN,APC,ARID1A,PBRM1,NAV3,NF1,CDKN2A,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,CTCF,BAP1,NPM1,IDH1,CRIPAK,KDM6A,EPHA3,AKT1,STAG2,AJUBA,EPPK1,SOX9,ATM,HGF,KDM5C,ERBB4,MTOR,TET2,ATRX,BRCA1,LRRK2,FOXA1,CHEK2,KIT,HIST1H1C,SETD2,PDGFRA,EP300,SMAD4,USP9X,BRCA2,ASXL1,PPP2R1A,ATR,SIN3A,HIST1H2BD,SMC1A,NSD1,TBL1XR1,MECOM,SMC3,NCOR1,RPL5,AXIN2,RAD21,ERCC2,EZH2
GO:0009628	response to abiotic stimulus	1.8430747145473024e-10	1.8430747145473024e-10	+1	TP53,PTEN,VHL,EGFR,NF1,GATA3,NOTCH1,MAP3K1,NFE2L2,NPM1,MAP2K4,STK11,AKT1,AJUBA,SOX9,ATM,MTOR,TLR4,BRCA1,KIT,EP300,CCND1,SMAD4,CDKN1A,TAF1,ATR,SMC1A,ERCC2
GO:0045926	negative regulation of growth	2.1461478575199567e-10	2.1461478575199567e-10	+1	TP53,PTEN,CDKN2A,RB1,NOTCH1,STK11,CDKN1B,WT1,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0007507	heart development	2.730945080001493e-10	2.730945080001493e-10	+1	PTEN,EGFR,NF1,GATA3,RB1,NOTCH1,CTNNB1,TBX3,SOX9,CDKN1B,WT1,ERBB4,PDGFRA,FGFR2,SMAD4,TGFBR2,SOX17,CDKN1A,PTPN11
GO:0010648	negative regulation of cell communication	3.0649735221813156e-10	3.0649735221813156e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,CRIPAK,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,TGFBR2,SOX17,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0001558	regulation of cell growth	3.25190567429347e-10	3.25190567429347e-10	+1	TP53,EGFR,CDKN2A,RB1,BAP1,STK11,AKT1,CDKN1B,WT1,MTOR,SMAD4,SOX17,CDKN1A,PPP2R1A,SIN3A,ACVR1B,H3F3C,CDKN2C
GO:1901987	regulation of cell cycle phase transition	3.25190567429347e-10	3.25190567429347e-10	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,FBXW7,NPM1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,TAF1,PPP2R1A,ERCC2,CDKN2C,EZH2
GO:0023057	negative regulation of signaling	3.388120850860242e-10	3.388120850860242e-10	+1	PTEN,APC,VHL,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,ARHGAP35,NFE2L2,STK11,CRIPAK,AKT1,AR,AJUBA,SOX9,ATM,HGF,TLR4,BRCA1,LRRK2,SMAD4,ASXL1,TGFBR2,SOX17,PPP2R1A,MAPK8IP1,MECOM,NCOR1,SMAD2,AXIN2,EZH2
GO:0051094	positive regulation of developmental process	3.489898825050103e-10	3.489898825050103e-10	+1	VHL,CDKN2A,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,AR,SOX9,WT1,HGF,ERBB4,MTOR,BRCA1,KIT,EP300,FGFR2,SMAD4,FOXA2,TGFBR2,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0033674	positive regulation of kinase activity	4.010007132924778e-10	4.010007132924778e-10	+1	EGFR,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,PIK3CG,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,EZH2
GO:0014065	phosphatidylinositol 3-kinase signaling	4.0630527732044573e-10	4.0630527732044573e-10	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:1901564	organonitrogen compound metabolic process	4.2777900307112664e-10	4.2777900307112664e-10	+1	TP53,PTEN,APC,VHL,KRAS,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,NFE2L2,BAP1,NPM1,NRAS,MAP2K4,RPL22,STK11,CRIPAK,CEBPA,KDM6A,EPHA3,AKT1,BRAF,AR,PIK3CG,SOX9,ATM,CDKN1B,HGF,KDM5C,ERBB4,MTOR,TLR4,TET2,ATRX,BRCA1,LRRK2,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,CDKN1A,B4GALT3,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,EIF4A2,CDK12,PTPN11,ACVR1B,MAPK8IP1,NSD1,TBL1XR1,ACVR2A,MECOM,NCOR1,RPL5,SMAD2,SPOP,AXIN2,CDKN2C,EZH2
GO:0044843	cell cycle G1/S phase transition	4.575488465351461e-10	4.575488465351461e-10	+1	TP53,PTEN,EGFR,CDKN2A,RB1,FBXW7,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,TAF1,ACVR1B,CDKN2C,EZH2
GO:0000278	mitotic cell cycle	5.201643996076262e-10	5.201643996076262e-10	+1	TP53,PTEN,APC,PBRM1,EGFR,CDKN2A,RB1,CTNNB1,MAP3K1,MAP2K4,AKT1,STAG2,AJUBA,ATM,CDKN1B,HGF,ATRX,FOXA1,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,PPP2R1A,SMC1A,ACVR1B,SMC3,ERCC2,CDKN2C
GO:0007154	cell communication	5.32200089971701e-10	5.32200089971701e-10	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0043408	regulation of MAPK cascade	5.59465251754909e-10	5.59465251754909e-10	+1	PTEN,EGFR,NF1,NOTCH1,FBXW7,FLT3,MAP2K4,BRAF,PIK3CG,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PPP2R1A,CDK12,PTPN11,MAPK8IP1,MECOM,NCOR1,EZH2
GO:0023052	signaling	5.650016903707744e-10	5.650016903707744e-10	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,TSHZ3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,EZH2
GO:0051347	positive regulation of transferase activity	8.595082554080116e-10	8.595082554080116e-10	+1	PTEN,EGFR,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,PIK3CG,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,EZH2
GO:0045936	negative regulation of phosphate metabolic process	8.971357611230144e-10	8.971357611230144e-10	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,TLR4,LRRK2,SMAD4,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,MECOM,NCOR1,CDKN2C
GO:0045787	positive regulation of cell cycle	9.168041110389203e-10	9.168041110389203e-10	+1	TP53,EGFR,RB1,NPM1,TBX3,AKT1,ATM,CDKN1B,ATRX,BRCA1,FOXA1,CHEK2,EP300,FGFR2,CCND1,CDKN1A,RAD21,EZH2
GO:0010563	negative regulation of phosphorus metabolic process	9.242334626238324e-10	9.242334626238324e-10	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,TLR4,LRRK2,SMAD4,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1,MECOM,NCOR1,CDKN2C
GO:0072359	circulatory system development	9.367289452471176e-10	9.367289452471176e-10	+1	PIK3CA,PTEN,EGFR,NF1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,TBX3,STK11,AKT1,SOX9,CDKN1B,WT1,ERBB4,BRCA1,KIT,PDGFRA,FGFR2,SMAD4,TGFBR2,SOX17,CDKN1A,PTPN11,EGR3
GO:0045786	negative regulation of cell cycle	1.0338520813271514e-9	1.0338520813271514e-9	+1	TP53,PTEN,APC,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,NPM1,STK11,CEBPA,ATM,CDKN1B,MTOR,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR,CDKN2C,EZH2
GO:0007050	cell cycle arrest	1.1902656517730272e-9	1.1902656517730272e-9	+1	TP53,APC,CDKN2A,RB1,NOTCH1,STK11,ATM,CDKN1B,MTOR,BRCA1,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0044770	cell cycle phase transition	1.2171425030304965e-9	1.2171425030304965e-9	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,FBXW7,NPM1,AKT1,AJUBA,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,TAF1,PPP2R1A,ACVR1B,ERCC2,CDKN2C,EZH2
GO:2000026	regulation of multicellular organismal development	1.3622527100287737e-9	1.3622527100287737e-9	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,EP300,FGFR2,SMAD4,FOXA2,BRCA2,TGFBR2,SOX17,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0007165	signal transduction	1.4595091942597305e-9	1.4595091942597305e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,PIK3CG,SOX9,ATM,CDKN1B,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,FOXA1,CHEK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,CDK12,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,EZH2
GO:0007346	regulation of mitotic cell cycle	1.4687783023272772e-9	1.4687783023272772e-9	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,CTNNB1,MAP3K1,MAP2K4,AKT1,STAG2,ATM,CDKN1B,ATRX,FOXA1,CHEK2,EP300,CCND1,CDKN1A,PPP2R1A,SMC1A,SMC3,ERCC2,CDKN2C
GO:0001933	negative regulation of protein phosphorylation	2.0273262728980744e-9	2.0273262728980744e-9	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,TLR4,LRRK2,SMAD4,CDKN1A,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0051052	regulation of DNA metabolic process	2.098693115142346e-9	2.098693115142346e-9	+1	TP53,EGFR,CDKN2A,NPM1,AKT1,ATM,WT1,HGF,ATRX,BRCA1,POLQ,HIST1H1C,SETD2,USP9X,ATR,AXIN2,ERCC2
GO:0010941	regulation of cell death	2.1701193483639846e-9	2.1701193483639846e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,ATM,CDKN1B,WT1,HGF,TLR4,BRCA1,LRRK2,FOXA1,FGFR2,EGR3,MECOM,AXIN2
GO:0045597	positive regulation of cell differentiation	2.196926617272387e-9	2.196926617272387e-9	+1	VHL,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,AR,SOX9,HGF,MTOR,KIT,EP300,SMAD4,TGFBR2,CBFB,SIN3A,VEZF1,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0033043	regulation of organelle organization	2.3412199905383123e-9	2.3412199905383123e-9	+1	TP53,APC,NAV3,RB1,FBXW7,CTNNB1,ARHGAP35,CTCF,BAP1,NPM1,CRIPAK,EPHA3,AKT1,STAG2,ATM,HGF,MTOR,ATRX,BRCA1,LRRK2,HIST1H1C,PDGFRA,EP300,SMAD4,ATR,SIN3A,SMC1A,NSD1,SMC3,AXIN2,RAD21
GO:0009653	anatomical structure morphogenesis	2.5136913521928387e-9	2.5136913521928387e-9	+1	PIK3CA,PTEN,VHL,NF1,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,BRAF,SOX9,WT1,HGF,ERBB4,MTOR,ELF3,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,USP9X,FGFR3,ASXL1,TGFBR2,SOX17,SIN3A,PTPN11,EGR3,SMAD2,AXIN2
GO:0007166	cell surface receptor signaling pathway	2.667245916039929e-9	2.667245916039929e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,RUNX1,NRAS,MAP2K4,STK11,CEBPA,EPHA3,AKT1,AR,SOX9,HGF,ERBB4,TLR4,ELF3,BRCA1,LRRK2,KIT,PDGFRA,EP300,FGFR2,CCND1,SMAD4,USP9X,FGFR3,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,ACVR2A,LIFR,SMAD2,AXIN2
GO:0044093	positive regulation of molecular function	3.1769229798912463e-9	3.1769229798912463e-9	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,FBXW7,CTNNB1,MAP3K1,FLT3,NPM1,MAP2K4,STK11,EPHA3,AKT1,BRAF,AR,PIK3CG,ERBB4,MTOR,TLR4,ARID5B,LRRK2,FOXA1,KIT,PDGFRA,EP300,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,TAF1,EZH2
GO:2000045	regulation of G1/S transition of mitotic cell cycle	4.9349362074579675e-9	4.9349362074579675e-9	+1	TP53,PTEN,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0048015	phosphatidylinositol-mediated signaling	6.684359797493178e-9	6.684359797493178e-9	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0048017	inositol lipid-mediated signaling	7.1762930650028874e-9	7.1762930650028874e-9	+1	PIK3CA,PTEN,EGFR,NF1,PIK3R1,GATA3,FLT3,AKT1,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:1902533	positive regulation of intracellular signal transduction	7.783802116029209e-9	7.783802116029209e-9	+1	TP53,PIK3CA,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,MAP2K4,AKT1,BRAF,PIK3CG,SOX9,ATM,HGF,ERBB4,TLR4,LRRK2,KIT,PDGFRA,EP300,FGFR2,FGFR3,ATR,PTPN11,MAPK8IP1,EZH2
GO:0051239	regulation of multicellular organismal process	7.961487229780015e-9	7.961487229780015e-9	+1	PTEN,APC,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,TSHZ3,ARHGAP35,RUNX1,STK11,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,LRRK2,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,BRCA2,TGFBR2,SOX17,CBFB,SIN3A,VEZF1,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0050896	response to stimulus	8.158977242380152e-9	8.158977242380152e-9	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,ARID1A,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,ARHGAP35,NFE2L2,NPM1,RUNX1,NRAS,IDH1,TBX3,MAP2K4,STK11,CRIPAK,CEBPA,EPHA3,AKT1,BRAF,AR,AJUBA,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,ERBB4,MTOR,TLR4,ATRX,ELF3,BRCA1,LRRK2,POLQ,FOXA1,CHEK2,KIT,SETD2,PDGFRA,EP300,FGFR2,CCND1,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,VEZF1,CDK12,SMC1A,PTPN11,ACVR1B,MAPK8IP1,TBL1XR1,EGR3,ACVR2A,MECOM,LIFR,NCOR1,RPL5,SMAD2,AXIN2,MIR142,RAD21,ERCC2,EZH2
GO:0033673	negative regulation of kinase activity	8.926469399362625e-9	8.926469399362625e-9	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1
GO:0007167	enzyme linked receptor protein signaling pathway	1.2504727063620558e-8	1.2504727063620558e-8	+1	PIK3CA,APC,EGFR,PIK3R1,GATA3,NOTCH1,FBXW7,FLT3,STK11,EPHA3,AKT1,SOX9,HGF,ERBB4,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,PTPN11,ACVR1B,ACVR2A,LIFR,SMAD2
GO:0080135	regulation of cellular response to stress	1.413818955462643e-8	1.413818955462643e-8	+1	EGFR,PIK3R1,CDKN2A,FBXW7,NFE2L2,NPM1,MAP2K4,AKT1,AJUBA,ATM,HGF,MTOR,TLR4,BRCA1,LRRK2,POLQ,SETD2,EP300,ATR,MAPK8IP1,MECOM,NCOR1,AXIN2
GO:0030308	negative regulation of cell growth	1.6530232597677384e-8	1.6530232597677384e-8	+1	TP53,CDKN2A,RB1,STK11,CDKN1B,WT1,SMAD4,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
GO:0043069	negative regulation of programmed cell death	1.7193614440684966e-8	1.7193614440684966e-8	+1	TP53,PIK3CA,VHL,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,WT1,HGF,BRCA1,LRRK2,FGFR2,EGR3,MECOM
GO:0002520	immune system development	1.762037085117299e-8	1.762037085117299e-8	+1	TP53,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,TET2,POLQ,KIT,PDGFRA,EP300,FGFR2,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A,MECOM
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	1.786221954324624e-8	1.786221954324624e-8	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:0090068	positive regulation of cell cycle process	1.8049720860395815e-8	1.8049720860395815e-8	+1	TP53,EGFR,RB1,NPM1,AKT1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,RAD21,EZH2
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	1.8902318086767327e-8	1.8902318086767327e-8	+1	TP53,PTEN,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0030097	hemopoiesis	1.9523563346775735e-8	1.9523563346775735e-8	+1	TP53,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,TET2,KIT,PDGFRA,EP300,FGFR2,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A,MECOM
GO:0030518	intracellular steroid hormone receptor signaling pathway	2.0586004544723793e-8	2.0586004544723793e-8	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0043067	regulation of programmed cell death	2.2999100370809347e-8	2.2999100370809347e-8	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,BRCA1,LRRK2,FOXA1,FGFR2,EGR3,MECOM
GO:0014070	response to organic cyclic compound	2.431538853103627e-8	2.431538853103627e-8	+1	ARID1A,EGFR,RB1,CTNNB1,CDH1,NPM1,RUNX1,CRIPAK,AR,WT1,BRCA1,LRRK2,FOXA1,EP300,TGFBR2,TAF1,CBFB,NCOR1,SMAD2
GO:0051896	regulation of protein kinase B signaling	2.549349731877558e-8	2.549349731877558e-8	+1	PIK3CA,PTEN,EGFR,PIK3R1,GATA3,AKT1,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0009314	response to radiation	2.5642287761343376e-8	2.5642287761343376e-8	+1	TP53,EGFR,NF1,GATA3,NPM1,STK11,AKT1,ATM,BRCA1,EP300,CCND1,CDKN1A,TAF1,ATR,SMC1A,ERCC2
GO:0009887	animal organ morphogenesis	2.5722501781350212e-8	2.5722501781350212e-8	+1	PTEN,NF1,GATA3,NOTCH1,FBXW7,CTNNB1,TBX3,BRAF,SOX9,WT1,HGF,ELF3,LRRK2,PDGFRA,FGFR2,SMAD4,FGFR3,ASXL1,TGFBR2,SOX17,SMAD2,AXIN2
GO:0008284	positive regulation of cell population proliferation	2.5785174656373006e-8	2.5785174656373006e-8	+1	PTEN,KRAS,EGFR,NOTCH1,CTNNB1,FLT3,NPM1,NRAS,TBX3,AKT1,AR,SOX9,ERBB4,TLR4,PDGFRA,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,EGR3,LIFR,EZH2
GO:0010718	positive regulation of epithelial to mesenchymal transition	2.6607723629729662e-8	2.6607723629729662e-8	+1	NOTCH1,CTNNB1,MTOR,SMAD4,TGFBR2,SMAD2,AXIN2,EZH2
GO:1904029	regulation of cyclin-dependent protein kinase activity	2.6696289452710615e-8	2.6696289452710615e-8	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
GO:1902807	negative regulation of cell cycle G1/S phase transition	2.8361826437648262e-8	2.8361826437648262e-8	+1	TP53,PTEN,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0009411	response to UV	2.8361826437648262e-8	2.8361826437648262e-8	+1	TP53,EGFR,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
GO:0043401	steroid hormone mediated signaling pathway	2.8361826437648262e-8	2.8361826437648262e-8	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0048534	hematopoietic or lymphoid organ development	2.8973344467533723e-8	2.8973344467533723e-8	+1	TP53,CDKN2A,GATA3,NOTCH1,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,TET2,KIT,PDGFRA,EP300,FGFR2,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A,MECOM
GO:0071407	cellular response to organic cyclic compound	3.126687189353625e-8	3.126687189353625e-8	+1	ARID1A,EGFR,RB1,CTNNB1,CDH1,NPM1,RUNX1,CRIPAK,AR,WT1,BRCA1,LRRK2,FOXA1,EP300,TAF1,CBFB,NCOR1
GO:0006469	negative regulation of protein kinase activity	3.176789048303901e-8	3.176789048303901e-8	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,CDKN1A,PPP2R1A,MAPK8IP1
GO:0033993	response to lipid	4.138672624140016e-8	4.138672624140016e-8	+1	ARID1A,EGFR,RB1,CTNNB1,RUNX1,CRIPAK,EPHA3,AR,SOX9,ATM,TLR4,BRCA1,FOXA1,EP300,ASXL1,TGFBR2,CBFB,NCOR1,SMAD2,MIR142
GO:0043066	negative regulation of apoptotic process	5.092538890069789e-8	5.092538890069789e-8	+1	TP53,PIK3CA,VHL,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,WT1,HGF,BRCA1,LRRK2,FGFR2,EGR3
GO:0030879	mammary gland development	5.20530194204616e-8	5.20530194204616e-8	+1	GATA3,ARHGAP35,TBX3,AKT1,ERBB4,ELF3,FGFR2,BRCA2
GO:0007059	chromosome segregation	5.372170647023906e-8	5.372170647023906e-8	+1	APC,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,BRCA1,PPP2R1A,SMC1A,SMC3,AXIN2,RAD21,ERCC2
GO:0042981	regulation of apoptotic process	5.380598346877449e-8	5.380598346877449e-8	+1	TP53,PIK3CA,PTEN,APC,VHL,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,ATM,WT1,HGF,BRCA1,LRRK2,FOXA1,FGFR2,EGR3
GO:0043491	protein kinase B signaling	5.539262421872933e-8	5.539262421872933e-8	+1	PIK3CA,PTEN,EGFR,PIK3R1,GATA3,AKT1,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0051897	positive regulation of protein kinase B signaling	6.147299306991947e-8	6.147299306991947e-8	+1	PIK3CA,EGFR,PIK3R1,GATA3,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0006259	DNA metabolic process	6.67782946011685e-8	6.67782946011685e-8	+1	TP53,EGFR,CDKN2A,DNMT3A,NPM1,AKT1,ATM,WT1,HGF,TET2,ATRX,BRCA1,POLQ,CHEK2,HIST1H1C,SETD2,EP300,USP9X,BRCA2,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:0104004	cellular response to environmental stimulus	6.762458029684194e-8	6.762458029684194e-8	+1	TP53,PTEN,GATA3,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
GO:0071214	cellular response to abiotic stimulus	6.762458029684194e-8	6.762458029684194e-8	+1	TP53,PTEN,GATA3,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
GO:0044087	regulation of cellular component biogenesis	7.662935056283336e-8	7.662935056283336e-8	+1	TP53,PTEN,APC,NAV3,RB1,NOTCH1,ARHGAP35,NPM1,RUNX1,EPHA3,STAG2,AJUBA,ATM,TLR4,BRCA1,LRRK2,EP300,SMAD4,CBFB,ATR,SMC1A,PTPN11,SMC3,ERCC2
GO:0071363	cellular response to growth factor stimulus	7.74712047844241e-8	7.74712047844241e-8	+1	EGFR,GATA3,NOTCH1,CTNNB1,STK11,AKT1,SOX9,HGF,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,PTPN11,ACVR1B,EGR3,ACVR2A,SMAD2
GO:0051093	negative regulation of developmental process	7.803310607153011e-8	7.803310607153011e-8	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,TBX3,SOX9,CDKN1B,WT1,TLR4,FOXA1,SMAD4,FOXA2,BRCA2,FGFR3,ASXL1,CDKN1A,CBFB
GO:0051240	positive regulation of multicellular organismal process	7.924811749591902e-8	7.924811749591902e-8	+1	PTEN,APC,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,WT1,HGF,ERBB4,MTOR,TLR4,BRCA1,KIT,SETD2,EP300,FGFR2,SMAD4,FOXA2,TGFBR2,CBFB,SIN3A,PTPN11,ACVR1B,ACVR2A,SMAD2,AXIN2,MIR142,EZH2
GO:0010948	negative regulation of cell cycle process	8.107610459866385e-8	8.107610459866385e-8	+1	TP53,PTEN,APC,CDKN2A,RB1,NPM1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,CDKN2C,EZH2
GO:0060548	negative regulation of cell death	8.557334622419875e-8	8.557334622419875e-8	+1	TP53,PIK3CA,VHL,EGFR,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,NFE2L2,NPM1,TBX3,AKT1,BRAF,AR,SOX9,WT1,HGF,BRCA1,LRRK2,FGFR2,EGR3,MECOM
GO:0000082	G1/S transition of mitotic cell cycle	8.564666709473273e-8	8.564666709473273e-8	+1	TP53,PTEN,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,ACVR1B,CDKN2C
GO:1903047	mitotic cell cycle process	9.771685522523021e-8	9.771685522523021e-8	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,AKT1,STAG2,AJUBA,ATM,CDKN1B,ATRX,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,PPP2R1A,SMC1A,ACVR1B,SMC3,ERCC2,CDKN2C
GO:0032870	cellular response to hormone stimulus	1.15857798470524e-7	1.15857798470524e-7	+1	PIK3CA,APC,ARID1A,EGFR,PIK3R1,RB1,NOTCH1,CTNNB1,RUNX1,CRIPAK,AKT1,AR,WT1,BRCA1,FOXA1,EP300,CBFB,PTPN11,NCOR1
GO:0050821	protein stabilization	1.2263417290245699e-7	1.2263417290245699e-7	+1	PTEN,VHL,PIK3R1,CDKN2A,FBXW7,CHEK2,EP300,USP9X,SOX17,CDKN1A,TAF1,RPL5
GO:0070848	response to growth factor	1.2263417290245699e-7	1.2263417290245699e-7	+1	EGFR,GATA3,NOTCH1,CTNNB1,STK11,AKT1,SOX9,HGF,PDGFRA,EP300,FGFR2,SMAD4,USP9X,FGFR3,TGFBR2,PTPN11,ACVR1B,EGR3,ACVR2A,SMAD2
GO:0034968	histone lysine methylation	1.300344355498871e-7	1.300344355498871e-7	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0007063	regulation of sister chromatid cohesion	1.320884995608162e-7	1.320884995608162e-7	+1	RB1,CTNNB1,CTCF,ATRX,AXIN2,RAD21
GO:0043086	negative regulation of catalytic activity	1.3619909667600103e-7	1.3619909667600103e-7	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NOTCH1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,HGF,LRRK2,FOXA2,CDKN1A,PPP2R1A,EIF4A2,MAPK8IP1,RPL5
GO:0000819	sister chromatid segregation	1.4665458029713402e-7	1.4665458029713402e-7	+1	APC,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0031647	regulation of protein stability	1.520955477158541e-7	1.520955477158541e-7	+1	PTEN,VHL,KRAS,PIK3R1,CDKN2A,FBXW7,LRRK2,CHEK2,EP300,USP9X,SOX17,CDKN1A,TAF1,RPL5
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	1.5459422097138053e-7	1.5459422097138053e-7	+1	PIK3CA,PTEN,EGFR,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0030522	intracellular receptor signaling pathway	1.8074603561802583e-7	1.8074603561802583e-7	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,ASXL1,CBFB,NCOR1,EZH2
GO:1901700	response to oxygen-containing compound	1.8208951347956636e-7	1.8208951347956636e-7	+1	TP53,PIK3CA,APC,EGFR,PIK3R1,CTNNB1,CDH1,NFE2L2,EPHA3,AKT1,SOX9,ATM,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,FOXA1,PDGFRA,FOXA2,ASXL1,TGFBR2,TAF1,PTPN11,SMAD2,MIR142
GO:0071383	cellular response to steroid hormone stimulus	2.0255296405918288e-7	2.0255296405918288e-7	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0097190	apoptotic signaling pathway	2.1664686989163574e-7	2.1664686989163574e-7	+1	TP53,PTEN,RB1,FBXW7,NFE2L2,STK11,AKT1,AR,ATM,HGF,TLR4,BRCA1,LRRK2,CHEK2,EP300,FGFR3,CDKN1A,ACVR1B
GO:0016570	histone modification	2.1914200524333325e-7	2.1914200524333325e-7	+1	CTNNB1,BAP1,KDM6A,KDM5C,TET2,ATRX,BRCA1,SETD2,EP300,SMAD4,BRCA2,ASXL1,SIN3A,NSD1,TBL1XR1,EZH2
GO:0051248	negative regulation of protein metabolic process	2.520278252574915e-7	2.520278252574915e-7	+1	PTEN,APC,EGFR,NF1,CDKN2A,RB1,CTNNB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,HGF,TLR4,BRCA1,LRRK2,SMAD4,CDKN1A,TAF1,PPP2R1A,SIN3A,MAPK8IP1,MECOM,NCOR1,RPL5
GO:0009725	response to hormone	2.5646711028853126e-7	2.5646711028853126e-7	+1	PIK3CA,APC,ARID1A,EGFR,PIK3R1,RB1,NOTCH1,CTNNB1,RUNX1,CRIPAK,AKT1,AR,WT1,BRCA1,FOXA1,EP300,CCND1,CBFB,PTPN11,NCOR1
GO:0090399	replicative senescence	2.661419426701931e-7	2.661419426701931e-7	+1	TP53,CDKN2A,ATM,CHEK2,ATR
GO:0032269	negative regulation of cellular protein metabolic process	3.085215394048109e-7	3.085215394048109e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,CTNNB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,HGF,TLR4,BRCA1,LRRK2,SMAD4,CDKN1A,TAF1,PPP2R1A,SIN3A,MAPK8IP1,MECOM,NCOR1,RPL5
GO:0071901	negative regulation of protein serine/threonine kinase activity	3.217061235199352e-7	3.217061235199352e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,CEBPA,AKT1,CDKN1B,PPP2R1A,MAPK8IP1
GO:2000677	regulation of transcription regulatory region DNA binding	3.3168844619441243e-7	3.3168844619441243e-7	+1	GATA3,RB1,CTNNB1,EP300,TAF1,SIN3A,NSD1
GO:0045860	positive regulation of protein kinase activity	3.673578084405059e-7	3.673578084405059e-7	+1	EGFR,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,AKT1,BRAF,PIK3CG,MTOR,TLR4,LRRK2,KIT,CCND1,TGFBR2,CDKN1A,EZH2
GO:1904030	negative regulation of cyclin-dependent protein kinase activity	3.950852459228779e-7	3.950852459228779e-7	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B,CDKN1A
GO:0009894	regulation of catabolic process	4.322871216573276e-7	4.322871216573276e-7	+1	TP53,PIK3CA,PTEN,APC,EGFR,CDKN2A,FBXW7,KEAP1,NFE2L2,NPM1,STK11,CEBPA,AKT1,ATM,CDKN1B,HGF,MTOR,LRRK2,CHEK2,EP300,TAF1,NCOR1,RPL5,AXIN2
GO:0016569	covalent chromatin modification	4.4955204833634415e-7	4.4955204833634415e-7	+1	CTNNB1,BAP1,KDM6A,KDM5C,TET2,ATRX,BRCA1,SETD2,EP300,SMAD4,BRCA2,ASXL1,SIN3A,NSD1,TBL1XR1,EZH2
GO:0018022	peptidyl-lysine methylation	5.658121956273402e-7	5.658121956273402e-7	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0072331	signal transduction by p53 class mediator	6.16190575653822e-7	6.16190575653822e-7	+1	TP53,STK11,AKT1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,TAF1,ATR,RPL5
GO:0030155	regulation of cell adhesion	6.268682489959266e-7	6.268682489959266e-7	+1	PIK3CA,PTEN,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,CDH1,RUNX1,EPHA3,AKT1,PIK3CG,ATM,FOXA1,FOXA2,TGFBR2,PPP2R1A,CBFB,PTPN11
GO:0043410	positive regulation of MAPK cascade	6.322570312114137e-7	6.322570312114137e-7	+1	EGFR,NOTCH1,FBXW7,FLT3,MAP2K4,BRAF,PIK3CG,ERBB4,TLR4,LRRK2,KIT,PDGFRA,FGFR2,FGFR3,PTPN11,MAPK8IP1,EZH2
GO:0018108	peptidyl-tyrosine phosphorylation	6.398598170791912e-7	6.398598170791912e-7	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
GO:0009755	hormone-mediated signaling pathway	7.269549094003634e-7	7.269549094003634e-7	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0018212	peptidyl-tyrosine modification	7.332314148542591e-7	7.332314148542591e-7	+1	TP53,EGFR,FBXW7,FLT3,EPHA3,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PPP2R1A,PTPN11
GO:0022607	cellular component assembly	7.563486915616221e-7	7.563486915616221e-7	+1	TP53,PTEN,APC,NAV3,CDKN2A,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,CTCF,NPM1,RUNX1,EPHA3,STAG2,AJUBA,EPPK1,SOX9,ATM,TLR4,ATRX,BRCA1,LRRK2,POLQ,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,CBFB,ATR,HIST1H2BD,SMC1A,PTPN11,SMC3,NCOR1,RPL5,SMAD2,AXIN2,ERCC2
GO:1901988	negative regulation of cell cycle phase transition	8.385889974086935e-7	8.385889974086935e-7	+1	TP53,PTEN,APC,CDKN2A,RB1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0032501	multicellular organismal process	8.466860304018959e-7	8.466860304018959e-7	+1	TP53,PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,FLT3,TSHZ3,CDH1,ARHGAP35,RUNX1,TBX3,STK11,CEBPA,EPHA3,AKT1,BRAF,EPPK1,PIK3CG,SOX9,ATM,CDKN1B,WT1,HGF,PRX,ERBB4,MTOR,TLR4,ARID5B,TET2,ELF3,BRCA1,LRRK2,POLQ,FOXA1,KIT,SETD2,PDGFRA,EP300,FGFR2,SMAD4,FOXA2,USP9X,BRCA2,FGFR3,ASXL1,TGFBR2,SOX17,CDKN1A,TAF1,CBFB,ATR,SIN3A,VEZF1,PTPN11,ACVR1B,EGR3,ACVR2A,MECOM,SMAD2,AXIN2,MIR142,ERCC2,EZH2
GO:0006974	cellular response to DNA damage stimulus	9.025570323561498e-7	9.025570323561498e-7	+1	TP53,APC,EGFR,NPM1,STK11,ATM,CDKN1B,ATRX,BRCA1,POLQ,CHEK2,SETD2,EP300,CCND1,BRCA2,CDKN1A,TAF1,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:1901990	regulation of mitotic cell cycle phase transition	9.064060282831889e-7	9.064060282831889e-7	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,PPP2R1A,ERCC2,CDKN2C
GO:0071396	cellular response to lipid	0.000001000630355345279	0.000001000630355345279	+1	ARID1A,EGFR,RB1,CTNNB1,RUNX1,CRIPAK,EPHA3,AR,SOX9,ATM,TLR4,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0044092	negative regulation of molecular function	0.0000010896273465620561	0.0000010896273465620561	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NOTCH1,KEAP1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,HGF,LRRK2,FOXA2,CDKN1A,TAF1,PPP2R1A,SIN3A,EIF4A2,MAPK8IP1,RPL5
GO:0030330	DNA damage response, signal transduction by p53 class mediator	0.000001103625111065131	0.000001103625111065131	+1	TP53,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,ATR
GO:0070371	ERK1 and ERK2 cascade	0.000001126072698172511	0.000001126072698172511	+1	PTEN,EGFR,NOTCH1,FBXW7,BRAF,SOX9,ERBB4,TLR4,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
GO:0051241	negative regulation of multicellular organismal process	0.000001126072698172511	0.000001126072698172511	+1	PTEN,NAV3,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,RUNX1,STK11,EPPK1,PIK3CG,SOX9,WT1,TLR4,LRRK2,FOXA1,PDGFRA,SMAD4,FOXA2,BRCA2,CBFB,MIR142
GO:0070647	protein modification by small protein conjugation or removal	0.000001165171676643974	0.000001165171676643974	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,CTNNB1,KEAP1,NFE2L2,BAP1,AKT1,AR,BRCA1,LRRK2,EP300,SMAD4,USP9X,ASXL1,TAF1,CBFB,HIST1H2BD,RPL5,SMAD2
GO:0071824	protein-DNA complex subunit organization	0.0000013383407369035046	0.0000013383407369035046	+1	TP53,ARID1A,PBRM1,RB1,CTCF,NPM1,SOX9,ATRX,HIST1H1C,SETD2,TAF1,HIST1H2BD,ERCC2
GO:0048511	rhythmic process	0.0000013436885929929914	0.0000013436885929929914	+1	TP53,PTEN,FBXW7,MTOR,PDGFRA,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:0009416	response to light stimulus	0.0000013810757826236577	0.0000013810757826236577	+1	TP53,EGFR,NF1,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
GO:0033044	regulation of chromosome organization	0.000001384327508914054	0.000001384327508914054	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,BRCA1,HIST1H1C,SMAD4,ATR,SIN3A,NSD1,AXIN2,RAD21
GO:0060429	epithelium development	0.0000013943998575301945	0.0000013943998575301945	+1	PTEN,GATA3,NOTCH1,CTNNB1,ARHGAP35,RUNX1,TBX3,AKT1,EPPK1,SOX9,WT1,HGF,ERBB4,MTOR,ELF3,FGFR2,SMAD4,BRCA2,TGFBR2,SOX17,CBFB,VEZF1,ERCC2
GO:0048545	response to steroid hormone	0.000001405085414646283	0.000001405085414646283	+1	ARID1A,RB1,CTNNB1,RUNX1,CRIPAK,AR,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0045930	negative regulation of mitotic cell cycle	0.0000014261635822738246	0.0000014261635822738246	+1	TP53,PTEN,APC,CDKN2A,RB1,CTNNB1,ATM,CDKN1B,ATRX,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	0.000001448860224532212	0.000001448860224532212	+1	PIK3CA,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
GO:0044772	mitotic cell cycle phase transition	0.000001546061868742029	0.000001546061868742029	+1	TP53,PTEN,APC,EGFR,CDKN2A,RB1,AKT1,AJUBA,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,PPP2R1A,ACVR1B,ERCC2,CDKN2C
GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	0.0000016341865377517057	0.0000016341865377517057	+1	PTEN,APC,EGFR,GATA3,CTNNB1,RUNX1,STK11,AKT1,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,MAPK8IP1,TBL1XR1,AXIN2
GO:0043405	regulation of MAP kinase activity	0.0000018369293863739583	0.0000018369293863739583	+1	EGFR,NF1,FLT3,MAP2K4,BRAF,PIK3CG,TLR4,LRRK2,KIT,PPP2R1A,CDK12,MAPK8IP1,EZH2
GO:0016571	histone methylation	0.0000018708531156401812	0.0000018708531156401812	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0110110	positive regulation of animal organ morphogenesis	0.000001874084151747323	0.000001874084151747323	+1	GATA3,NOTCH1,SOX9,WT1,FGFR2,SMAD4,TGFBR2
GO:0033045	regulation of sister chromatid segregation	0.000001929509491964607	0.000001929509491964607	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,AXIN2,RAD21
GO:0045596	negative regulation of cell differentiation	0.000002037529926829168	0.000002037529926829168	+1	PTEN,EGFR,NF1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,RUNX1,TBX3,SOX9,TLR4,FOXA1,SMAD4,FOXA2,ASXL1,CBFB
GO:0034502	protein localization to chromosome	0.0000021138466044949375	0.0000021138466044949375	+1	RB1,CTCF,ATM,ATRX,SETD2,BRCA2,ATR,RAD21
GO:0030111	regulation of Wnt signaling pathway	0.0000021138466044949375	0.0000021138466044949375	+1	APC,EGFR,CTNNB1,RUNX1,STK11,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,MAPK8IP1,TBL1XR1,AXIN2
GO:0016055	Wnt signaling pathway	0.0000021714289422782468	0.0000021714289422782468	+1	PTEN,APC,EGFR,GATA3,CTNNB1,RUNX1,STK11,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,MAPK8IP1,TBL1XR1,AXIN2
GO:0098813	nuclear chromosome segregation	0.0000023503048664711628	0.0000023503048664711628	+1	APC,RB1,FBXW7,CTNNB1,CTCF,STAG2,ATM,ATRX,SMC1A,SMC3,AXIN2,RAD21
GO:0030521	androgen receptor signaling pathway	0.0000023833178435018316	0.0000023833178435018316	+1	ARID1A,RB1,CTNNB1,AR,BRCA1,EP300,NCOR1
GO:0198738	cell-cell signaling by wnt	0.0000024379808588349894	0.0000024379808588349894	+1	PTEN,APC,EGFR,GATA3,CTNNB1,RUNX1,STK11,SOX9,LRRK2,FGFR2,SOX17,PPP2R1A,CBFB,MAPK8IP1,TBL1XR1,AXIN2
GO:1901991	negative regulation of mitotic cell cycle phase transition	0.0000026790041553507953	0.0000026790041553507953	+1	TP53,PTEN,APC,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
GO:0016579	protein deubiquitination	0.0000028043748235377465	0.0000028043748235377465	+1	TP53,PTEN,APC,GATA3,KEAP1,BAP1,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,SMAD2
GO:0043085	positive regulation of catalytic activity	0.0000029254263351873475	0.0000029254263351873475	+1	PTEN,EGFR,NF1,CDKN2A,FBXW7,MAP3K1,FLT3,MAP2K4,STK11,EPHA3,AKT1,BRAF,PIK3CG,ERBB4,MTOR,TLR4,LRRK2,KIT,PDGFRA,FGFR2,CCND1,FGFR3,TGFBR2,CDKN1A,EZH2
GO:1901699	cellular response to nitrogen compound	0.00000312518101168119	0.00000312518101168119	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,NPM1,AKT1,SOX9,WT1,MTOR,TLR4,ATRX,BRCA1,LRRK2,TAF1,PTPN11
GO:0048863	stem cell differentiation	0.000003170306415032186	0.000003170306415032186	+1	TP53,GATA3,NOTCH1,RUNX1,SOX9,ERBB4,KIT,SETD2,PDGFRA,FGFR2,CBFB
GO:0007569	cell aging	0.0000032910123675725663	0.0000032910123675725663	+1	TP53,CDKN2A,NPM1,TBX3,ATM,CHEK2,CDKN1A,ATR
GO:0042060	wound healing	0.000003549547889366209	0.000003549547889366209	+1	PIK3CA,PTEN,NF1,PIK3R1,GATA3,ARHGAP35,EPPK1,PIK3CG,CDKN1B,ERBB4,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A,PTPN11
GO:0051090	regulation of DNA-binding transcription factor activity	0.000003699226429219811	0.000003699226429219811	+1	PTEN,CDKN2A,RB1,CTNNB1,KEAP1,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,FOXA2,TAF1
GO:0007568	aging	0.000003766733553707198	0.000003766733553707198	+1	TP53,CDKN2A,NPM1,TBX3,ATM,LRRK2,CHEK2,CDKN1A,ATR
GO:0007623	circadian rhythm	0.0000038031700768039682	0.0000038031700768039682	+1	TP53,PTEN,FBXW7,MTOR,EP300,USP9X,SIN3A,EGR3,NCOR1,EZH2
GO:1901701	cellular response to oxygen-containing compound	0.000003936885276876911	0.000003936885276876911	+1	TP53,PIK3CA,APC,EGFR,PIK3R1,CTNNB1,CDH1,NFE2L2,EPHA3,AKT1,SOX9,ATM,WT1,HGF,MTOR,TLR4,BRCA1,LRRK2,PDGFRA,FOXA2,TAF1,PTPN11
GO:0030099	myeloid cell differentiation	0.000004061641919226261	0.000004061641919226261	+1	FBXW7,RUNX1,CEBPA,MTOR,TLR4,TET2,KIT,EP300,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A
GO:0070372	regulation of ERK1 and ERK2 cascade	0.000004244741653656566	0.000004244741653656566	+1	PTEN,EGFR,NOTCH1,FBXW7,BRAF,ERBB4,TLR4,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
GO:0000075	cell cycle checkpoint	0.000004637879688019479	0.000004637879688019479	+1	TP53,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0009790	embryo development	0.000004796569682062722	0.000004796569682062722	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,WT1,ERBB4,BRCA1,KIT,SETD2,PDGFRA,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0060070	canonical Wnt signaling pathway	0.000005050279536420048	0.000005050279536420048	+1	PTEN,APC,EGFR,GATA3,CTNNB1,STK11,SOX9,LRRK2,FGFR2,SOX17,MAPK8IP1,TBL1XR1,AXIN2
GO:0048589	developmental growth	0.000005050279536420048	0.000005050279536420048	+1	PTEN,NOTCH1,CTNNB1,EPPK1,SOX9,CDKN1B,WT1,ERBB4,FGFR2,USP9X,FGFR3,CDKN1A,SIN3A
GO:0031571	mitotic G1 DNA damage checkpoint	0.0000052011235029048006	0.0000052011235029048006	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0044819	mitotic G1/S transition checkpoint	0.0000052011235029048006	0.0000052011235029048006	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0070646	protein modification by small protein removal	0.0000052011235029048006	0.0000052011235029048006	+1	TP53,PTEN,APC,GATA3,KEAP1,BAP1,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,SMAD2
GO:0007399	nervous system development	0.000005736448911978405	0.000005736448911978405	+1	PIK3CA,PTEN,NAV3,NF1,PIK3R1,GATA3,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,RUNX1,TBX3,EPHA3,AKT1,SOX9,PRX,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,TGFBR2,TAF1,SIN3A,PTPN11,ACVR1B,MIR142,ERCC2
GO:0044783	G1 DNA damage checkpoint	0.00000575007329104537	0.00000575007329104537	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0044085	cellular component biogenesis	0.00000575007329104537	0.00000575007329104537	+1	TP53,PTEN,APC,NAV3,CDKN2A,RB1,NOTCH1,CTNNB1,CDH1,ARHGAP35,CTCF,NPM1,RUNX1,EPHA3,STAG2,AJUBA,EPPK1,SOX9,ATM,TLR4,ATRX,BRCA1,LRRK2,POLQ,CHEK2,KIT,HIST1H1C,PDGFRA,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,CBFB,ATR,HIST1H2BD,SMC1A,PTPN11,SMC3,NCOR1,RPL5,SMAD2,AXIN2,ERCC2
GO:0042770	signal transduction in response to DNA damage	0.000005868024183664643	0.000005868024183664643	+1	TP53,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A,ATR
GO:0006338	chromatin remodeling	0.000006120654443801228	0.000006120654443801228	+1	ARID1A,PBRM1,CDKN2A,RB1,NPM1,KDM6A,SOX9,KDM5C,ATRX,FOXA1
GO:0006333	chromatin assembly or disassembly	0.000006434615784673083	0.000006434615784673083	+1	TP53,ARID1A,PBRM1,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD
GO:0051054	positive regulation of DNA metabolic process	0.000006434615784673083	0.000006434615784673083	+1	EGFR,AKT1,ATM,WT1,HGF,ATRX,BRCA1,USP9X,ATR,ERCC2
GO:0048729	tissue morphogenesis	0.000006555413842196982	0.000006555413842196982	+1	PTEN,GATA3,NOTCH1,CTNNB1,ARHGAP35,TBX3,SOX9,WT1,HGF,MTOR,FGFR2,SMAD4,TGFBR2,SOX17,SMAD2
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	0.000006612014653335868	0.000006612014653335868	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:1901796	regulation of signal transduction by p53 class mediator	0.000006743097495506494	0.000006743097495506494	+1	TP53,STK11,AKT1,ATM,BRCA1,CHEK2,EP300,TAF1,ATR,RPL5
GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	0.0000069833204005814526	0.0000069833204005814526	+1	RUNX1,CRIPAK,BRCA1,FOXA1,EP300,CBFB,NCOR1
GO:0018205	peptidyl-lysine modification	0.000007305138444399056	0.000007305138444399056	+1	CDKN2A,CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,EP300,SMAD4,BRCA2,SIN3A,NSD1,EZH2
GO:2000027	regulation of animal organ morphogenesis	0.000007876916971919584	0.000007876916971919584	+1	GATA3,NOTCH1,FBXW7,CTNNB1,SOX9,WT1,HGF,FGFR2,SMAD4,TGFBR2
GO:0034097	response to cytokine	0.000008014249113536734	0.000008014249113536734	+1	TP53,PIK3CA,PIK3R1,GATA3,FLT3,NFE2L2,RUNX1,CEBPA,AKT1,SOX9,HGF,TLR4,BRCA1,KIT,SETD2,CCND1,SMAD4,FOXA2,CDKN1A,CBFB,PTPN11,LIFR,MIR142
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	0.000008176031639959176	0.000008176031639959176	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B
GO:0071496	cellular response to external stimulus	0.000008506120145336384	0.000008506120145336384	+1	TP53,MAP3K1,ARHGAP35,MAP2K4,SOX9,MTOR,TLR4,LRRK2,FOXA2,CDKN1A,TAF1
GO:0033365	protein localization to organelle	0.000009376097253581446	0.000009376097253581446	+1	TP53,APC,PIK3R1,RB1,FBXW7,CDH1,CTCF,BAP1,IDH1,RPL22,AKT1,ATM,ATRX,LRRK2,SETD2,USP9X,BRCA2,ATR,SIN3A,RPL5,RAD21
GO:0002009	morphogenesis of an epithelium	0.000009937416716164852	0.000009937416716164852	+1	PTEN,GATA3,NOTCH1,CTNNB1,ARHGAP35,TBX3,SOX9,WT1,HGF,MTOR,FGFR2,TGFBR2,SOX17
GO:0034644	cellular response to UV	0.00001032025856098565	0.00001032025856098565	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0051983	regulation of chromosome segregation	0.000010488020783233838	0.000010488020783233838	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,AXIN2,RAD21
GO:0000077	DNA damage checkpoint	0.00001066986445084214	0.00001066986445084214	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0048638	regulation of developmental growth	0.000011120075461122977	0.000011120075461122977	+1	PTEN,NOTCH1,EPPK1,CDKN1B,WT1,ERBB4,FGFR2,FGFR3,CDKN1A,SIN3A
GO:1903827	regulation of cellular protein localization	0.000011390904397493918	0.000011390904397493918	+1	TP53,APC,EGFR,PIK3R1,RB1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,AR,LRRK2,SETD2,SIN3A
GO:0042176	regulation of protein catabolic process	0.000012486202996467331	0.000012486202996467331	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,LRRK2,CHEK2,TAF1,RPL5
GO:0050678	regulation of epithelial cell proliferation	0.00001276902307971158	0.00001276902307971158	+1	EGFR,NF1,GATA3,FBXW7,NRAS,AKT1,EPPK1,SOX9,TLR4,FGFR2,BRCA2,EGR3
GO:0071156	regulation of cell cycle arrest	0.000012934523349841926	0.000012934523349841926	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A
GO:0072401	signal transduction involved in DNA integrity checkpoint	0.000013455884602764243	0.000013455884602764243	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0072422	signal transduction involved in DNA damage checkpoint	0.000013455884602764243	0.000013455884602764243	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0001763	morphogenesis of a branching structure	0.000013455884602764243	0.000013455884602764243	+1	CTNNB1,SOX9,WT1,HGF,LRRK2,FGFR2,TGFBR2
GO:0003179	heart valve morphogenesis	0.000013857875203292901	0.000013857875203292901	+1	GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2
GO:0072395	signal transduction involved in cell cycle checkpoint	0.000014671400393765966	0.000014671400393765966	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0008213	protein alkylation	0.000014757143528590258	0.000014757143528590258	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0009611	response to wounding	0.000014757143528590258	0.000014757143528590258	+1	PIK3CA,PTEN,NF1,PIK3R1,GATA3,ARHGAP35,EPPK1,PIK3CG,CDKN1B,ERBB4,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A,PTPN11
GO:0006479	protein methylation	0.000014757143528590258	0.000014757143528590258	+1	CTNNB1,KDM6A,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0001656	metanephros development	0.000015496186276178993	0.000015496186276178993	+1	NF1,GATA3,SOX9,WT1,PDGFRA,SOX17
GO:0043550	regulation of lipid kinase activity	0.000015496186276178993	0.000015496186276178993	+1	PIK3R1,RB1,FLT3,KIT,PDGFRA,FGFR3
GO:0065008	regulation of biological quality	0.000015588260005278064	0.000015588260005278064	+1	TP53,PIK3CA,PTEN,APC,VHL,KRAS,NF1,PIK3R1,CDKN2A,GATA3,RB1,NOTCH1,FBXW7,FLT3,TSHZ3,KEAP1,ARHGAP35,NFE2L2,NPM1,TBX3,STK11,CEBPA,AKT1,PIK3CG,SOX9,ATM,ERBB4,MTOR,TLR4,ATRX,LRRK2,CHEK2,KIT,PDGFRA,EP300,SMAD4,FOXA2,USP9X,SOX17,CDKN1A,TAF1,ATR,SIN3A,PTPN11,ACVR1B,ACVR2A,RPL5,AXIN2
GO:0071417	cellular response to organonitrogen compound	0.000016673907574266263	0.000016673907574266263	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,AKT1,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,TAF1,PTPN11
GO:0019216	regulation of lipid metabolic process	0.00001678930818110335	0.00001678930818110335	+1	PIK3R1,RB1,FBXW7,FLT3,AKT1,MTOR,BRCA1,KIT,PDGFRA,FGFR3,SIN3A,TBL1XR1,NCOR1
GO:0097193	intrinsic apoptotic signaling pathway	0.000016801460624881527	0.000016801460624881527	+1	TP53,FBXW7,NFE2L2,STK11,AKT1,ATM,BRCA1,LRRK2,CHEK2,EP300,CDKN1A
GO:0001822	kidney development	0.00001725187077328577	0.00001725187077328577	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:0030520	intracellular estrogen receptor signaling pathway	0.000017326303991490898	0.000017326303991490898	+1	ARID1A,RUNX1,CRIPAK,BRCA1,FOXA1,CBFB
GO:0061180	mammary gland epithelium development	0.000017706365222727528	0.000017706365222727528	+1	GATA3,AKT1,ERBB4,FGFR2,BRCA2
GO:0006352	DNA-templated transcription, initiation	0.0000180521840032089	0.0000180521840032089	+1	TP53,PTEN,NOTCH1,CTNNB1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
GO:0048568	embryonic organ development	0.0000180521840032089	0.0000180521840032089	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,KIT,PDGFRA,FGFR2,TGFBR2,SOX17
GO:0070602	regulation of centromeric sister chromatid cohesion	0.000018164992655726878	0.000018164992655726878	+1	CTNNB1,CTCF,AXIN2
GO:0048699	generation of neurons	0.00001823802465483404	0.00001823802465483404	+1	PIK3CA,PTEN,NF1,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,SIN3A,PTPN11,MIR142,ERCC2
GO:0031570	DNA integrity checkpoint	0.000018991149950528812	0.000018991149950528812	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
GO:0016477	cell migration	0.000019344298321971065	0.000019344298321971065	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0051091	positive regulation of DNA-binding transcription factor activity	0.000019344298321971065	0.000019344298321971065	+1	PTEN,CTNNB1,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,TAF1
GO:0051129	negative regulation of cellular component organization	0.000019558586327176526	0.000019558586327176526	+1	PTEN,APC,NAV3,NOTCH1,NPM1,EPHA3,AKT1,AR,ATM,HGF,ATRX,BRCA1,LRRK2,HIST1H1C,EP300,SMAD4,SIN3A
GO:0072001	renal system development	0.000021034216551747416	0.000021034216551747416	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:0071158	positive regulation of cell cycle arrest	0.00002177425525635422	0.00002177425525635422	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
GO:0002244	hematopoietic progenitor cell differentiation	0.000022653111160760516	0.000022653111160760516	+1	TP53,GATA3,NOTCH1,FLT3,RUNX1,KIT,PDGFRA,CBFB
GO:1902532	negative regulation of intracellular signal transduction	0.000023339276899131606	0.000023339276899131606	+1	PTEN,NF1,ARHGAP35,NFE2L2,STK11,AKT1,AJUBA,ATM,TLR4,LRRK2,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0003170	heart valve development	0.000024084062389497013	0.000024084062389497013	+1	GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2
GO:0006367	transcription initiation from RNA polymerase II promoter	0.00002435526178008031	0.00002435526178008031	+1	TP53,PTEN,NOTCH1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
GO:0043276	anoikis	0.000024646327312727314	0.000024646327312727314	+1	PIK3CA,NOTCH1,STK11,AKT1,MTOR
GO:0009880	embryonic pattern specification	0.000024646327312727314	0.000024646327312727314	+1	TBX3,WT1,ERBB4,FGFR2,SMAD2
GO:0022612	gland morphogenesis	0.000024646327312727314	0.000024646327312727314	+1	FBXW7,SOX9,HGF,ELF3,FGFR2
GO:0071478	cellular response to radiation	0.00002561654008896081	0.00002561654008896081	+1	TP53,GATA3,NPM1,STK11,ATM,EP300,CDKN1A,TAF1,ATR
GO:0043414	macromolecule methylation	0.000026991194475089884	0.000026991194475089884	+1	CTNNB1,DNMT3A,KDM6A,WT1,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	0.00002743246445697597	0.00002743246445697597	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	0.00003139065970157484	0.00003139065970157484	+1	TP53,EGFR,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PPP2R1A,PTPN11
GO:2001252	positive regulation of chromosome organization	0.00003139065970157484	0.00003139065970157484	+1	RB1,CTNNB1,ATM,ATRX,BRCA1,SMAD4,ATR,SIN3A,RAD21
GO:0007155	cell adhesion	0.000032461178145392575	0.000032461178145392575	+1	PIK3CA,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,RUNX1,EPHA3,AKT1,PIK3CG,ATM,FOXA1,KIT,PDGFRA,FOXA2,TGFBR2,PPP2R1A,CBFB,PTPN11
GO:0048598	embryonic morphogenesis	0.00003267585867595632	0.00003267585867595632	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,SETD2,PDGFRA,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0060562	epithelial tube morphogenesis	0.00003267585867595632	0.00003267585867595632	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,WT1,FGFR2,TGFBR2,SOX17
GO:0001655	urogenital system development	0.00003267585867595632	0.00003267585867595632	+1	NF1,GATA3,CTNNB1,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
GO:0007093	mitotic cell cycle checkpoint	0.00003267585867595632	0.00003267585867595632	+1	TP53,APC,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0050673	epithelial cell proliferation	0.00003348626031703852	0.00003348626031703852	+1	EGFR,NF1,GATA3,FBXW7,NRAS,AKT1,EPPK1,SOX9,TLR4,FGFR2,BRCA2,EGR3
GO:0031329	regulation of cellular catabolic process	0.00003380127831669168	0.00003380127831669168	+1	TP53,PIK3CA,PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,NPM1,STK11,CEBPA,AKT1,ATM,HGF,MTOR,LRRK2,EP300,TAF1,RPL5,AXIN2
GO:0071902	positive regulation of protein serine/threonine kinase activity	0.00003448166445409731	0.00003448166445409731	+1	EGFR,FLT3,MAP2K4,AKT1,BRAF,PIK3CG,TLR4,LRRK2,KIT,CCND1,EZH2
GO:0022610	biological adhesion	0.00003544951868603563	0.00003544951868603563	+1	PIK3CA,PTEN,APC,EGFR,NF1,PIK3R1,CDKN2A,GATA3,NOTCH1,CTNNB1,CDH1,RUNX1,EPHA3,AKT1,PIK3CG,ATM,FOXA1,KIT,PDGFRA,FOXA2,TGFBR2,PPP2R1A,CBFB,PTPN11
GO:0045165	cell fate commitment	0.000035804788675249394	0.000035804788675249394	+1	APC,GATA3,TBX3,SOX9,WT1,FGFR2,FOXA2,SOX17,SMAD2
GO:0003151	outflow tract morphogenesis	0.00003601462621441341	0.00003601462621441341	+1	NOTCH1,CTNNB1,FGFR2,SMAD4,TGFBR2,SOX17
GO:0018105	peptidyl-serine phosphorylation	0.000036849615504865485	0.000036849615504865485	+1	PTEN,EGFR,AKT1,BRAF,ATM,MTOR,LRRK2,TGFBR2,TAF1,ATR,NSD1
GO:0034728	nucleosome organization	0.00003927375906057786	0.00003927375906057786	+1	ARID1A,PBRM1,CTCF,NPM1,SOX9,ATRX,HIST1H1C,SETD2,HIST1H2BD
GO:0033146	regulation of intracellular estrogen receptor signaling pathway	0.00003927375906057786	0.00003927375906057786	+1	RUNX1,CRIPAK,BRCA1,FOXA1,CBFB
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	0.000039708462026374984	0.000039708462026374984	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0051130	positive regulation of cellular component organization	0.00003999806724229421	0.00003999806724229421	+1	TP53,APC,NAV3,RB1,FBXW7,CTNNB1,ARHGAP35,BAP1,EPHA3,AR,AJUBA,ATM,TLR4,ATRX,BRCA1,EP300,SMAD4,ATR,SIN3A,MAPK8IP1,RAD21,ERCC2
GO:0062197	cellular response to chemical stress	0.00004075845501117876	0.00004075845501117876	+1	TP53,EGFR,FBXW7,KEAP1,NFE2L2,AKT1,ATM,HGF,TLR4,LRRK2,PDGFRA
GO:0022008	neurogenesis	0.000040942437017543046	0.000040942437017543046	+1	PIK3CA,PTEN,NF1,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,SIN3A,PTPN11,MIR142,ERCC2
GO:0071680	response to indole-3-methanol	0.00004104504158726921	0.00004104504158726921	+1	CTNNB1,CDH1,BRCA1
GO:0071681	cellular response to indole-3-methanol	0.00004104504158726921	0.00004104504158726921	+1	CTNNB1,CDH1,BRCA1
GO:0006281	DNA repair	0.00004121216152491842	0.00004121216152491842	+1	TP53,EGFR,NPM1,ATM,BRCA1,POLQ,CHEK2,SETD2,EP300,BRCA2,ATR,SMC1A,AXIN2,RAD21,ERCC2
GO:0060828	regulation of canonical Wnt signaling pathway	0.00004181142655201023	0.00004181142655201023	+1	APC,EGFR,CTNNB1,STK11,SOX9,LRRK2,FGFR2,SOX17,MAPK8IP1,TBL1XR1,AXIN2
GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint	0.000043187401153744	0.000043187401153744	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:1902400	intracellular signal transduction involved in G1 DNA damage checkpoint	0.000043187401153744	0.000043187401153744	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:0009895	negative regulation of catabolic process	0.00004470598998202664	0.00004470598998202664	+1	PIK3CA,EGFR,CDKN2A,AKT1,HGF,MTOR,LRRK2,TAF1,NCOR1,RPL5,AXIN2
GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.000044842355797945355	0.000044842355797945355	+1	NOTCH1,STK11,EP300,SMAD4,ACVR1B,ACVR2A,SMAD2
GO:0032259	methylation	0.000047880702147191174	0.000047880702147191174	+1	CTNNB1,DNMT3A,KDM6A,WT1,TET2,ATRX,BRCA1,SETD2,SMAD4,NSD1,EZH2
GO:0050865	regulation of cell activation	0.000049386287846041664	0.000049386287846041664	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,CEBPA,AKT1,ATM,TLR4,PDGFRA,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:0003007	heart morphogenesis	0.00005106556451055827	0.00005106556451055827	+1	GATA3,NOTCH1,CTNNB1,TBX3,SOX9,FGFR2,SMAD4,TGFBR2,SOX17
GO:0010212	response to ionizing radiation	0.000051642314496086865	0.000051642314496086865	+1	TP53,GATA3,STK11,ATM,BRCA1,CDKN1A,ATR
GO:0072413	signal transduction involved in mitotic cell cycle checkpoint	0.000051883481835490416	0.000051883481835490416	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:1902403	signal transduction involved in mitotic DNA integrity checkpoint	0.000051883481835490416	0.000051883481835490416	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:1902402	signal transduction involved in mitotic DNA damage checkpoint	0.000051883481835490416	0.000051883481835490416	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
GO:1903706	regulation of hemopoiesis	0.00005319336735096042	0.00005319336735096042	+1	CDKN2A,GATA3,NOTCH1,FBXW7,RUNX1,MTOR,TLR4,EP300,TGFBR2,CBFB,SIN3A,ACVR1B,ACVR2A
GO:0070507	regulation of microtubule cytoskeleton organization	0.000055473831745244865	0.000055473831745244865	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,SMC1A,SMC3
GO:0060341	regulation of cellular localization	0.000056893905511960755	0.000056893905511960755	+1	TP53,PTEN,APC,EGFR,PIK3R1,RB1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,AR,LRRK2,SETD2,FOXA2,SIN3A
GO:0022409	positive regulation of cell-cell adhesion	0.000056893905511960755	0.000056893905511960755	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.00005917051196261968	0.00005917051196261968	+1	PIK3CA,APC,EGFR,PIK3R1,GATA3,FBXW7,FLT3,EPHA3,AKT1,SOX9,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0048562	embryonic organ morphogenesis	0.00006134305882131118	0.00006134305882131118	+1	NOTCH1,CTNNB1,TBX3,SOX9,PDGFRA,FGFR2,TGFBR2,SOX17
GO:1903201	regulation of oxidative stress-induced cell death	0.00006216434115154134	0.00006216434115154134	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0001944	vasculature development	0.00006414294825951419	0.00006414294825951419	+1	PIK3CA,NF1,NOTCH1,FBXW7,CTNNB1,RUNX1,STK11,AKT1,WT1,BRCA1,KIT,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0061041	regulation of wound healing	0.00006448914510842662	0.00006448914510842662	+1	PTEN,EPPK1,CDKN1B,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A
GO:0018209	peptidyl-serine modification	0.00006580181848795587	0.00006580181848795587	+1	PTEN,EGFR,AKT1,BRAF,ATM,MTOR,LRRK2,TGFBR2,TAF1,ATR,NSD1
GO:0006260	DNA replication	0.00006580181848795587	0.00006580181848795587	+1	EGFR,ATM,ATRX,BRCA1,POLQ,CHEK2,BRCA2,PPP2R1A,ATR,SMC3
GO:0051101	regulation of DNA binding	0.00006642270084174749	0.00006642270084174749	+1	GATA3,RB1,CTNNB1,EP300,TAF1,SIN3A,NSD1
GO:1901698	response to nitrogen compound	0.00006642270084174749	0.00006642270084174749	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,NFE2L2,NPM1,AKT1,SOX9,WT1,MTOR,TLR4,ATRX,BRCA1,LRRK2,TAF1,PTPN11
GO:0010639	negative regulation of organelle organization	0.00006642270084174749	0.00006642270084174749	+1	APC,NAV3,NPM1,AKT1,ATM,HGF,ATRX,BRCA1,LRRK2,HIST1H1C,SMAD4,SIN3A
GO:0061138	morphogenesis of a branching epithelium	0.00006720042493223211	0.00006720042493223211	+1	CTNNB1,SOX9,WT1,HGF,FGFR2,TGFBR2
GO:0072358	cardiovascular system development	0.00006729445009569621	0.00006729445009569621	+1	PIK3CA,NF1,NOTCH1,FBXW7,CTNNB1,RUNX1,STK11,AKT1,WT1,BRCA1,KIT,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0038127	ERBB signaling pathway	0.00007071322049117203	0.00007071322049117203	+1	PIK3CA,EGFR,PIK3R1,FBXW7,AKT1,SOX9,ERBB4,PTPN11
GO:0044773	mitotic DNA damage checkpoint	0.00007071322049117203	0.00007071322049117203	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0070141	response to UV-A	0.00007579035759772361	0.00007579035759772361	+1	EGFR,AKT1,CCND1
GO:0032927	positive regulation of activin receptor signaling pathway	0.00007579035759772361	0.00007579035759772361	+1	ACVR1B,ACVR2A,SMAD2
GO:0002682	regulation of immune system process	0.0000760615202345058	0.0000760615202345058	+1	PIK3CA,KRAS,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,MAP3K1,RUNX1,NRAS,MAP2K4,CEBPA,AKT1,SOX9,ATM,MTOR,TLR4,KIT,EP300,TGFBR2,CBFB,SIN3A,PTPN11,ACVR1B,MAPK8IP1,ACVR2A,MIR142
GO:0070374	positive regulation of ERK1 and ERK2 cascade	0.00007707195002500815	0.00007707195002500815	+1	EGFR,NOTCH1,FBXW7,BRAF,ERBB4,PDGFRA,FGFR2,FGFR3,PTPN11
GO:0034599	cellular response to oxidative stress	0.00007771371280580774	0.00007771371280580774	+1	TP53,EGFR,FBXW7,KEAP1,NFE2L2,AKT1,HGF,TLR4,LRRK2,PDGFRA
GO:0007389	pattern specification process	0.00007771371280580774	0.00007771371280580774	+1	APC,NOTCH1,TBX3,WT1,ERBB4,FGFR2,FOXA2,TGFBR2,SOX17,SMAD2
GO:0001667	ameboidal-type cell migration	0.00008119028472500806	0.00008119028472500806	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,SOX9,ERBB4,MTOR,KIT,ACVR1B,EGR3
GO:0098609	cell-cell adhesion	0.00008145826095233315	0.00008145826095233315	+1	PIK3CA,EGFR,PIK3R1,CDKN2A,GATA3,CTNNB1,CDH1,RUNX1,AKT1,PIK3CG,FOXA1,KIT,PDGFRA,FOXA2,TGFBR2,CBFB,PTPN11
GO:0048870	cell motility	0.00009171378078553793	0.00009171378078553793	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0051674	localization of cell	0.00009171378078553793	0.00009171378078553793	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0071345	cellular response to cytokine stimulus	0.00009411947357466485	0.00009411947357466485	+1	TP53,PIK3CA,PIK3R1,GATA3,FLT3,NFE2L2,RUNX1,CEBPA,AKT1,SOX9,HGF,TLR4,BRCA1,KIT,CCND1,SMAD4,CDKN1A,CBFB,PTPN11,LIFR
GO:0002694	regulation of leukocyte activation	0.00009416279927397755	0.00009416279927397755	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,CEBPA,AKT1,ATM,TLR4,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:0022407	regulation of cell-cell adhesion	0.0000947364646339671	0.0000947364646339671	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,CDH1,RUNX1,AKT1,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:0043551	regulation of phosphatidylinositol 3-kinase activity	0.00009581238621103903	0.00009581238621103903	+1	PIK3R1,FLT3,KIT,PDGFRA,FGFR3
GO:0035265	organ growth	0.00009603747494145207	0.00009603747494145207	+1	PTEN,NOTCH1,SOX9,WT1,ERBB4,FGFR2,FGFR3
GO:0042110	T cell activation	0.00009695191115464213	0.00009695191115464213	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,PIK3CG,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process	0.00010211462943229131	0.00010211462943229131	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0048608	reproductive structure development	0.0001043026920543929	0.0001043026920543929	+1	GATA3,TBX3,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
GO:0061458	reproductive system development	0.0001043026920543929	0.0001043026920543929	+1	GATA3,TBX3,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
GO:1903050	regulation of proteolysis involved in cellular protein catabolic process	0.00010613396883491329	0.00010613396883491329	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:0003281	ventricular septum development	0.00010725047044195598	0.00010725047044195598	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0007548	sex differentiation	0.00010782237392503397	0.00010782237392503397	+1	GATA3,TBX3,SOX9,WT1,KIT,PDGFRA,PTPN11
GO:0031497	chromatin assembly	0.00010892336008239524	0.00010892336008239524	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD
GO:0002521	leukocyte differentiation	0.00011007005426617115	0.00011007005426617115	+1	CDKN2A,GATA3,FBXW7,FLT3,RUNX1,CEBPA,ATM,MTOR,TLR4,KIT,TGFBR2,CBFB
GO:0007417	central nervous system development	0.00011007005426617115	0.00011007005426617115	+1	PTEN,NF1,NOTCH1,CTNNB1,ARHGAP35,TBX3,SOX9,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,SIN3A,PTPN11,MIR142
GO:0044774	mitotic DNA integrity checkpoint	0.00011396585625960846	0.00011396585625960846	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GO:0045732	positive regulation of protein catabolic process	0.00011396585625960846	0.00011396585625960846	+1	PTEN,APC,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,LRRK2,TAF1
GO:0051493	regulation of cytoskeleton organization	0.00011589195617292478	0.00011589195617292478	+1	APC,NAV3,CTNNB1,ARHGAP35,NPM1,CRIPAK,EPHA3,STAG2,MTOR,BRCA1,PDGFRA,SMAD4,SMC1A,SMC3
GO:0030182	neuron differentiation	0.00011590190755772897	0.00011590190755772897	+1	PIK3CA,PTEN,PIK3R1,RB1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,ERBB4,LRRK2,FOXA1,EP300,FGFR2,FOXA2,USP9X,SIN3A,PTPN11,ERCC2
GO:0032880	regulation of protein localization	0.00012276244578107132	0.00012276244578107132	+1	TP53,APC,EGFR,PIK3R1,GATA3,RB1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,AR,TLR4,LRRK2,SETD2,FOXA2,SIN3A,MIR142
GO:1900407	regulation of cellular response to oxidative stress	0.0001269464150640667	0.0001269464150640667	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0001501	skeletal system development	0.0001298625684473822	0.0001298625684473822	+1	TP53,FBXW7,CTNNB1,RUNX1,TBX3,SOX9,KIT,PDGFRA,FGFR2,FGFR3,TGFBR2
GO:0051568	histone H3-K4 methylation	0.00013364006991484963	0.00013364006991484963	+1	CTNNB1,KDM6A,TET2,BRCA1,SMAD4
GO:0048872	homeostasis of number of cells	0.00013539419450632717	0.00013539419450632717	+1	NOTCH1,FLT3,AKT1,SOX9,KIT,ACVR1B,ACVR2A
GO:0035295	tube development	0.0001401992978225901	0.0001401992978225901	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,TBX3,CEBPA,AKT1,SOX9,WT1,BRCA1,KIT,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	0.00014338871053899897	0.00014338871053899897	+1	TP53,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PTPN11
GO:0034613	cellular protein localization	0.00014859345422933473	0.00014859345422933473	+1	TP53,APC,EGFR,PIK3R1,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,IDH1,RPL22,EPHA3,AKT1,BRAF,AR,ATM,U2AF1,ATRX,LRRK2,SETD2,USP9X,BRCA2,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:0043409	negative regulation of MAPK cascade	0.00014990428179398218	0.00014990428179398218	+1	PTEN,NF1,TLR4,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
GO:0043933	protein-containing complex subunit organization	0.00014990428179398218	0.00014990428179398218	+1	TP53,APC,ARID1A,PBRM1,NAV3,RB1,CTNNB1,CTCF,NPM1,AJUBA,SOX9,ATM,TLR4,ATRX,LRRK2,POLQ,HIST1H1C,SETD2,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,ATR,HIST1H2BD,PTPN11,RPL5,SMAD2,AXIN2,ERCC2
GO:0045637	regulation of myeloid cell differentiation	0.00015476537007305294	0.00015476537007305294	+1	FBXW7,RUNX1,MTOR,TLR4,EP300,CBFB,SIN3A,ACVR1B,ACVR2A
GO:1903034	regulation of response to wounding	0.00015647465356702703	0.00015647465356702703	+1	PTEN,EPPK1,CDKN1B,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A
GO:0070727	cellular macromolecule localization	0.00016455278867078178	0.00016455278867078178	+1	TP53,APC,EGFR,PIK3R1,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,IDH1,RPL22,EPHA3,AKT1,BRAF,AR,ATM,U2AF1,ATRX,LRRK2,SETD2,USP9X,BRCA2,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:0032886	regulation of microtubule-based process	0.00016675479444687886	0.00016675479444687886	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,SMC1A,SMC3
GO:0006359	regulation of transcription by RNA polymerase III	0.00017155753549724927	0.00017155753549724927	+1	CEBPA,AR,MTOR,BRCA1
GO:2000679	positive regulation of transcription regulatory region DNA binding	0.00017155753549724927	0.00017155753549724927	+1	GATA3,RB1,CTNNB1,EP300
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	0.00017155753549724927	0.00017155753549724927	+1	NOTCH1,NFE2L2,EP300,SMAD4
GO:0043406	positive regulation of MAP kinase activity	0.00017217856173129548	0.00017217856173129548	+1	EGFR,FLT3,MAP2K4,BRAF,PIK3CG,TLR4,LRRK2,KIT,EZH2
GO:0030855	epithelial cell differentiation	0.0001722083414231965	0.0001722083414231965	+1	GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,SOX9,WT1,ERBB4,ELF3,FGFR2,SMAD4,SOX17,CBFB,VEZF1,ERCC2
GO:0022603	regulation of anatomical structure morphogenesis	0.00017349055761160126	0.00017349055761160126	+1	PTEN,NF1,GATA3,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,SOX9,WT1,HGF,MTOR,BRCA1,LRRK2,KIT,FGFR2,SMAD4,FOXA2,TGFBR2,SIN3A
GO:0009057	macromolecule catabolic process	0.00017466726271335515	0.00017466726271335515	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,RPL22,CEBPA,AKT1,ATM,CDKN1B,MTOR,LRRK2,CHEK2,USP9X,TAF1,PPP2R1A,TBL1XR1,RPL5,SPOP,AXIN2
GO:0006979	response to oxidative stress	0.0001755678861336249	0.0001755678861336249	+1	TP53,EGFR,FBXW7,KEAP1,NFE2L2,AKT1,HGF,TLR4,LRRK2,PDGFRA,ERCC2
GO:0071482	cellular response to light stimulus	0.00017575397426136186	0.00017575397426136186	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
GO:0050863	regulation of T cell activation	0.00017575397426136186	0.00017575397426136186	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0007173	epidermal growth factor receptor signaling pathway	0.00017575397426136186	0.00017575397426136186	+1	PIK3CA,EGFR,PIK3R1,FBXW7,AKT1,SOX9,PTPN11
GO:0006508	proteolysis	0.00017683830089375757	0.00017683830089375757	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,CTNNB1,KEAP1,NFE2L2,BAP1,CEBPA,AKT1,AR,HGF,BRCA1,LRRK2,EP300,SMAD4,USP9X,ASXL1,TAF1,TBL1XR1,RPL5,SMAD2,SPOP
GO:0009605	response to external stimulus	0.00018182552973379875	0.00018182552973379875	+1	TP53,PIK3CA,PTEN,KRAS,PIK3R1,GATA3,RB1,NOTCH1,MAP3K1,ARHGAP35,NRAS,MAP2K4,CEBPA,EPHA3,EPPK1,PIK3CG,SOX9,CDKN1B,HGF,MTOR,TLR4,LRRK2,KIT,SETD2,PDGFRA,EP300,FOXA2,CDKN1A,TAF1,SIN3A,PTPN11,EGR3,MIR142
GO:1903320	regulation of protein modification by small protein conjugation or removal	0.0001827543336458713	0.0001827543336458713	+1	PTEN,CDKN2A,FBXW7,CTNNB1,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0033002	muscle cell proliferation	0.0001830566778050881	0.0001830566778050881	+1	PTEN,NOTCH1,CTNNB1,AKT1,CDKN1B,ERBB4,FGFR2,CDKN1A
GO:0061026	cardiac muscle tissue regeneration	0.00018605132256247436	0.00018605132256247436	+1	CDKN1B,ERBB4,CDKN1A
GO:0003348	cardiac endothelial cell differentiation	0.00018605132256247436	0.00018605132256247436	+1	NOTCH1,SMAD4,SOX17
GO:0060956	endocardial cell differentiation	0.00018605132256247436	0.00018605132256247436	+1	NOTCH1,SMAD4,SOX17
GO:1902882	regulation of response to oxidative stress	0.00019182719051277796	0.00019182719051277796	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0010243	response to organonitrogen compound	0.00019663851538554184	0.00019663851538554184	+1	TP53,PIK3CA,APC,PIK3R1,CTNNB1,CDH1,NFE2L2,AKT1,SOX9,WT1,MTOR,TLR4,BRCA1,LRRK2,TAF1,PTPN11
GO:0044839	cell cycle G2/M phase transition	0.00019669718354878714	0.00019669718354878714	+1	TP53,CDKN2A,NPM1,AJUBA,ATM,BRCA1,CHEK2,CCND1,CDKN1A,PPP2R1A
GO:0016242	negative regulation of macroautophagy	0.00019897201703683164	0.00019897201703683164	+1	PIK3CA,AKT1,MTOR,LRRK2
GO:0036473	cell death in response to oxidative stress	0.00020518156176897406	0.00020518156176897406	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
GO:0048468	cell development	0.00021440039295035407	0.00021440039295035407	+1	PIK3CA,PTEN,NF1,PIK3R1,RB1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,SOX9,WT1,ERBB4,LRRK2,KIT,PDGFRA,EP300,FGFR2,SMAD4,USP9X,SIN3A,PTPN11,MIR142
GO:1902115	regulation of organelle assembly	0.00021600931925301698	0.00021600931925301698	+1	ARHGAP35,NPM1,STAG2,BRCA1,LRRK2,SMAD4,SMC1A,SMC3
GO:0040029	regulation of gene expression, epigenetic	0.0002161187359764136	0.0002161187359764136	+1	TP53,ARID1A,EGFR,DNMT3A,CTCF,AJUBA,BRCA1,HIST1H1C,EP300,SF3B1,SIN3A,NCOR1,SMAD2,MIR142,EZH2
GO:0072594	establishment of protein localization to organelle	0.00021637646591152524	0.00021637646591152524	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,IDH1,RPL22,AKT1,ATM,LRRK2,USP9X,BRCA2,ATR,RPL5
GO:0002696	positive regulation of leukocyte activation	0.00023377798462587647	0.00023377798462587647	+1	PIK3CA,PIK3R1,GATA3,RUNX1,CEBPA,AKT1,TLR4,TGFBR2,CBFB,PTPN11,MIR142
GO:0007622	rhythmic behavior	0.00023379827202290812	0.00023379827202290812	+1	TP53,PTEN,MTOR,NCOR1
GO:0048512	circadian behavior	0.00023379827202290812	0.00023379827202290812	+1	TP53,PTEN,MTOR,NCOR1
GO:0072089	stem cell proliferation	0.00023403036900703555	0.00023403036900703555	+1	NF1,CTNNB1,RUNX1,LRRK2,FGFR2,MECOM
GO:0045785	positive regulation of cell adhesion	0.0002388148259341469	0.0002388148259341469	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,ATM,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
GO:0010631	epithelial cell migration	0.000259732668842665	0.000259732668842665	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,SOX9,MTOR,KIT,EGR3
GO:0048646	anatomical structure formation involved in morphogenesis	0.0002627905497585348	0.0002627905497585348	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,AKT1,SOX9,WT1,BRCA1,SETD2,PDGFRA,FGFR2,SMAD4,FOXA2,TGFBR2,SOX17,EGR3,SMAD2
GO:0071479	cellular response to ionizing radiation	0.00026306684977352667	0.00026306684977352667	+1	TP53,GATA3,ATM,CDKN1A,ATR
GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	0.00026724918076616864	0.00026724918076616864	+1	EP300,TAF1,NSD1
GO:0045945	positive regulation of transcription by RNA polymerase III	0.00026724918076616864	0.00026724918076616864	+1	CEBPA,AR,MTOR
GO:0045475	locomotor rhythm	0.00026724918076616864	0.00026724918076616864	+1	PTEN,MTOR,NCOR1
GO:0032147	activation of protein kinase activity	0.00027101900263275724	0.00027101900263275724	+1	MAP3K1,MAP2K4,STK11,AKT1,BRAF,MTOR,TLR4,LRRK2,KIT,TGFBR2
GO:0090132	epithelium migration	0.00027101900263275724	0.00027101900263275724	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,SOX9,MTOR,KIT,EGR3
GO:0035690	cellular response to drug	0.00027101900263275724	0.00027101900263275724	+1	TP53,CTNNB1,CDH1,NFE2L2,SOX9,HGF,ATRX,BRCA1,LRRK2,TAF1
GO:0060688	regulation of morphogenesis of a branching structure	0.00027101900263275724	0.00027101900263275724	+1	SOX9,HGF,LRRK2,FGFR2
GO:0050870	positive regulation of T cell activation	0.0002728136568595119	0.0002728136568595119	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:1903364	positive regulation of cellular protein catabolic process	0.00027340366588714954	0.00027340366588714954	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0021953	central nervous system neuron differentiation	0.00028200016695920365	0.00028200016695920365	+1	PTEN,CTNNB1,ARHGAP35,ERBB4,FGFR2,SIN3A
GO:0030163	protein catabolic process	0.0002834312525805875	0.0002834312525805875	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,CDKN1B,MTOR,LRRK2,CHEK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0046425	regulation of receptor signaling pathway via JAK-STAT	0.0002868076296184318	0.0002868076296184318	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0090130	tissue migration	0.0002990814702412499	0.0002990814702412499	+1	PIK3CA,PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,SOX9,MTOR,KIT,EGR3
GO:0008593	regulation of Notch signaling pathway	0.00029991022320611843	0.00029991022320611843	+1	EGFR,NOTCH1,FBXW7,AKT1,ELF3,EP300
GO:1903362	regulation of cellular protein catabolic process	0.0003007335482217087	0.0003007335482217087	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
GO:0051098	regulation of binding	0.00030253050650552987	0.00030253050650552987	+1	GATA3,RB1,CTNNB1,AKT1,LRRK2,EP300,TAF1,SIN3A,NSD1,SMAD2
GO:0032879	regulation of localization	0.00030402376557456143	0.00030402376557456143	+1	TP53,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,BRAF,AR,EPPK1,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,LRRK2,KIT,SETD2,PDGFRA,FOXA2,SIN3A,PTPN11,ACVR1B,MAPK8IP1,MIR142
GO:0001708	cell fate specification	0.00030978184295626785	0.00030978184295626785	+1	APC,TBX3,SOX9,FOXA2,SOX17
GO:0050867	positive regulation of cell activation	0.0003127012604358263	0.0003127012604358263	+1	PIK3CA,PIK3R1,GATA3,RUNX1,CEBPA,AKT1,TLR4,TGFBR2,CBFB,PTPN11,MIR142
GO:0001666	response to hypoxia	0.0003318526114179235	0.0003318526114179235	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0030334	regulation of cell migration	0.0003321059943871007	0.0003321059943871007	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,SOX9,ATM,HGF,ERBB4,MTOR,KIT,PDGFRA,ACVR1B
GO:0046661	male sex differentiation	0.00033712803729010423	0.00033712803729010423	+1	GATA3,TBX3,SOX9,WT1,KIT
GO:0006275	regulation of DNA replication	0.00033712803729010423	0.00033712803729010423	+1	EGFR,ATRX,CHEK2,PPP2R1A,ATR,SMC3
GO:0003208	cardiac ventricle morphogenesis	0.00033712803729010423	0.00033712803729010423	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0061061	muscle structure development	0.0003398286438317899	0.0003398286438317899	+1	RB1,NOTCH1,CTNNB1,TBX3,SOX9,WT1,ERBB4,KIT,PDGFRA,FGFR2,SMAD4,EGR3
GO:0031330	negative regulation of cellular catabolic process	0.0003523609166188784	0.0003523609166188784	+1	PIK3CA,CDKN2A,AKT1,HGF,MTOR,LRRK2,TAF1,RPL5,AXIN2
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	0.00035723999843197064	0.00035723999843197064	+1	FLT3,KIT,PDGFRA,FGFR3
GO:0003180	aortic valve morphogenesis	0.00035723999843197064	0.00035723999843197064	+1	GATA3,RB1,NOTCH1,SOX9
GO:0070601	centromeric sister chromatid cohesion	0.00036158683625343613	0.00036158683625343613	+1	CTNNB1,CTCF,AXIN2
GO:0003157	endocardium development	0.00036158683625343613	0.00036158683625343613	+1	NOTCH1,SMAD4,SOX17
GO:0036293	response to decreased oxygen levels	0.0003617185606005525	0.0003617185606005525	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0008104	protein localization	0.0003832663861212144	0.0003832663861212144	+1	TP53,APC,EGFR,PIK3R1,GATA3,RB1,FBXW7,CTNNB1,KEAP1,CDH1,CTCF,BAP1,NPM1,IDH1,RPL22,EPHA3,AKT1,BRAF,AR,ATM,TLR4,U2AF1,ATRX,LRRK2,SETD2,FOXA2,USP9X,BRCA2,ATR,SIN3A,RPL5,AXIN2,MIR142,RAD21
GO:0048145	regulation of fibroblast proliferation	0.0003966822851839211	0.0003966822851839211	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:0031396	regulation of protein ubiquitination	0.0003966822851839211	0.0003966822851839211	+1	PTEN,CDKN2A,FBXW7,AKT1,BRCA1,LRRK2,TAF1,RPL5
GO:0010518	positive regulation of phospholipase activity	0.0003966822851839211	0.0003966822851839211	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0046620	regulation of organ growth	0.0003966822851839211	0.0003966822851839211	+1	PTEN,NOTCH1,WT1,ERBB4,FGFR2
GO:1901989	positive regulation of cell cycle phase transition	0.0004007898406112931	0.0004007898406112931	+1	EGFR,RB1,NPM1,AKT1,CCND1,EZH2
GO:0051548	negative regulation of keratinocyte migration	0.0004097454085176021	0.0004097454085176021	+1	PTEN,EPPK1
GO:1905179	negative regulation of cardiac muscle tissue regeneration	0.0004097454085176021	0.0004097454085176021	+1	CDKN1B,CDKN1A
GO:0060737	prostate gland morphogenetic growth	0.0004097454085176021	0.0004097454085176021	+1	SOX9,FGFR2
GO:1904882	regulation of telomerase catalytic core complex assembly	0.0004097454085176021	0.0004097454085176021	+1	ATM,ATR
GO:1904884	positive regulation of telomerase catalytic core complex assembly	0.0004097454085176021	0.0004097454085176021	+1	ATM,ATR
GO:1904868	telomerase catalytic core complex assembly	0.0004097454085176021	0.0004097454085176021	+1	ATM,ATR
GO:0007010	cytoskeleton organization	0.0004111133706869171	0.0004111133706869171	+1	APC,NAV3,NF1,CTNNB1,ARHGAP35,NPM1,CRIPAK,EPHA3,STAG2,AJUBA,EPPK1,MTOR,BRCA1,CHEK2,KIT,SETD2,PDGFRA,SMAD4,BRCA2,SMC1A,SMC3,NCOR1
GO:1901800	positive regulation of proteasomal protein catabolic process	0.00042124794685975865	0.00042124794685975865	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0031060	regulation of histone methylation	0.00042554765670041326	0.00042554765670041326	+1	CTNNB1,ATRX,BRCA1,SMAD4,NSD1
GO:0048144	fibroblast proliferation	0.00042554765670041326	0.00042554765670041326	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
GO:1904892	regulation of receptor signaling pathway via STAT	0.0004256928465571026	0.0004256928465571026	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0019827	stem cell population maintenance	0.00044549917629649127	0.00044549917629649127	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
GO:0060412	ventricular septum morphogenesis	0.00045913186698151186	0.00045913186698151186	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:2000826	regulation of heart morphogenesis	0.00045913186698151186	0.00045913186698151186	+1	NOTCH1,CTNNB1,SMAD4,TGFBR2
GO:0098727	maintenance of cell number	0.0004715985437856837	0.0004715985437856837	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
GO:2000136	regulation of cell proliferation involved in heart morphogenesis	0.00047434600423673905	0.00047434600423673905	+1	NOTCH1,CTNNB1,SMAD4
GO:0002053	positive regulation of mesenchymal cell proliferation	0.00047434600423673905	0.00047434600423673905	+1	SOX9,FGFR2,TGFBR2
GO:0002376	immune system process	0.0004766099122113857	0.0004766099122113857	+1	TP53,PIK3CA,KRAS,PIK3R1,CDKN2A,GATA3,NOTCH1,FBXW7,MAP3K1,FLT3,RUNX1,NRAS,IDH1,MAP2K4,CEBPA,AKT1,PIK3CG,SOX9,ATM,MTOR,TLR4,TET2,POLQ,KIT,SETD2,PDGFRA,EP300,FGFR2,TGFBR2,CBFB,SIN3A,PTPN11,ACVR1B,MAPK8IP1,ACVR2A,MECOM,MIR142
GO:0046649	lymphocyte activation	0.00048934673403949	0.00048934673403949	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,AKT1,PIK3CG,ATM,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0042752	regulation of circadian rhythm	0.0004971777561715519	0.0004971777561715519	+1	TP53,FBXW7,MTOR,USP9X,SIN3A,EZH2
GO:0010638	positive regulation of organelle organization	0.0004973074309369299	0.0004973074309369299	+1	TP53,NAV3,RB1,FBXW7,CTNNB1,ARHGAP35,BAP1,ATM,ATRX,BRCA1,SMAD4,ATR,SIN3A,RAD21
GO:0006323	DNA packaging	0.0005007663698544479	0.0005007663698544479	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD
GO:0070482	response to oxygen levels	0.0005007663698544479	0.0005007663698544479	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
GO:0040012	regulation of locomotion	0.000514144659395926	0.000514144659395926	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,ACVR1B
GO:0003176	aortic valve development	0.0005161345488171495	0.0005161345488171495	+1	GATA3,RB1,NOTCH1,SOX9
GO:0070198	protein localization to chromosome, telomeric region	0.0005161345488171495	0.0005161345488171495	+1	ATM,ATRX,BRCA2,ATR
GO:1903039	positive regulation of leukocyte cell-cell adhesion	0.0005170382051133002	0.0005170382051133002	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0035239	tube morphogenesis	0.000530967452613783	0.000530967452613783	+1	NF1,GATA3,NOTCH1,CTNNB1,RUNX1,TBX3,AKT1,SOX9,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0040011	locomotion	0.0005407964489446507	0.0005407964489446507	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:0010506	regulation of autophagy	0.0005493365003262163	0.0005493365003262163	+1	PIK3CA,FBXW7,KEAP1,STK11,AKT1,ATM,HGF,MTOR,LRRK2,EP300
GO:0001503	ossification	0.0005621419125966802	0.0005621419125966802	+1	EGFR,NF1,NOTCH1,RUNX1,SOX9,HGF,FGFR2,FGFR3,ACVR2A
GO:0002573	myeloid leukocyte differentiation	0.0005727164703623059	0.0005727164703623059	+1	FBXW7,RUNX1,CEBPA,MTOR,TLR4,KIT,TGFBR2
GO:0048754	branching morphogenesis of an epithelial tube	0.0005751212343493862	0.0005751212343493862	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
GO:0090218	positive regulation of lipid kinase activity	0.0005804259922244577	0.0005804259922244577	+1	FLT3,KIT,PDGFRA,FGFR3
GO:0003205	cardiac chamber development	0.0005804259922244577	0.0005804259922244577	+1	GATA3,NOTCH1,TBX3,FGFR2,SMAD4,TGFBR2
GO:1902105	regulation of leukocyte differentiation	0.0005931164431297716	0.0005931164431297716	+1	CDKN2A,GATA3,FBXW7,RUNX1,MTOR,TLR4,TGFBR2,CBFB
GO:0045662	negative regulation of myoblast differentiation	0.0006063817763801255	0.0006063817763801255	+1	NOTCH1,TBX3,SOX9
GO:0061323	cell proliferation involved in heart morphogenesis	0.0006063817763801255	0.0006063817763801255	+1	NOTCH1,CTNNB1,SMAD4
GO:0051547	regulation of keratinocyte migration	0.0006063817763801255	0.0006063817763801255	+1	PTEN,EPPK1,MTOR
GO:0016567	protein ubiquitination	0.0006438379324499208	0.0006438379324499208	+1	PTEN,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,AKT1,BRCA1,LRRK2,USP9X,TAF1,CBFB,HIST1H2BD,RPL5
GO:0038128	ERBB2 signaling pathway	0.0006530306038420098	0.0006530306038420098	+1	PIK3CA,EGFR,PIK3R1,ERBB4
GO:0007259	receptor signaling pathway via JAK-STAT	0.0006751895190379893	0.0006751895190379893	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:2001233	regulation of apoptotic signaling pathway	0.0007095786172638838	0.0007095786172638838	+1	TP53,PTEN,RB1,FBXW7,NFE2L2,AKT1,AR,HGF,BRCA1,LRRK2
GO:0071103	DNA conformation change	0.0007305342642847042	0.0007305342642847042	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD,ERCC2
GO:2000145	regulation of cell motility	0.0007305342642847042	0.0007305342642847042	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,SOX9,ATM,HGF,ERBB4,MTOR,KIT,PDGFRA,ACVR1B
GO:0010828	positive regulation of glucose transmembrane transport	0.0007328008869104136	0.0007328008869104136	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0007267	cell-cell signaling	0.0007497192749712577	0.0007497192749712577	+1	PTEN,APC,EGFR,GATA3,CTNNB1,TSHZ3,RUNX1,TBX3,STK11,AKT1,AR,SOX9,HGF,LRRK2,FGFR2,FOXA2,SOX17,PPP2R1A,CBFB,MAPK8IP1,TBL1XR1,AXIN2,MIR142
GO:0000226	microtubule cytoskeleton organization	0.0007646147021790405	0.0007646147021790405	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,CHEK2,SETD2,BRCA2,SMC1A,SMC3,NCOR1
GO:0003279	cardiac septum development	0.000767914443032414	0.000767914443032414	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.0008052977792770509	0.0008052977792770509	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0043627	response to estrogen	0.0008138386329786707	0.0008138386329786707	+1	GATA3,CRIPAK,BRCA1,EP300
GO:0007405	neuroblast proliferation	0.0008138386329786707	0.0008138386329786707	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:0010942	positive regulation of cell death	0.0008138386329786707	0.0008138386329786707	+1	TP53,PTEN,APC,NF1,CDKN2A,NOTCH1,FBXW7,CTNNB1,ATM,CDKN1B,TLR4,LRRK2,FOXA1,AXIN2
GO:0046622	positive regulation of organ growth	0.0008138386329786707	0.0008138386329786707	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0060421	positive regulation of heart growth	0.0008138386329786707	0.0008138386329786707	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0010517	regulation of phospholipase activity	0.0008187710021034154	0.0008187710021034154	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0065003	protein-containing complex assembly	0.0009091433281714068	0.0009091433281714068	+1	TP53,APC,NAV3,RB1,CTNNB1,NPM1,AJUBA,SOX9,ATM,TLR4,ATRX,LRRK2,POLQ,EP300,SMAD4,SF3B1,TAF1,PPP2R1A,ATR,HIST1H2BD,PTPN11,RPL5,SMAD2,AXIN2,ERCC2
GO:1905314	semi-lunar valve development	0.0009091433281714068	0.0009091433281714068	+1	GATA3,RB1,NOTCH1,SOX9
GO:1903037	regulation of leukocyte cell-cell adhesion	0.0009094108901398886	0.0009094108901398886	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:2000736	regulation of stem cell differentiation	0.0009205429445730923	0.0009205429445730923	+1	GATA3,NOTCH1,RUNX1,SOX9,PDGFRA,CBFB
GO:0044265	cellular macromolecule catabolic process	0.0009214095031053937	0.0009214095031053937	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,RPL22,CEBPA,AKT1,ATM,LRRK2,CHEK2,USP9X,TAF1,PPP2R1A,TBL1XR1,RPL5,SPOP,AXIN2
GO:0071241	cellular response to inorganic substance	0.0009230337639255422	0.0009230337639255422	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,ATRX,LRRK2
GO:0061045	negative regulation of wound healing	0.000934819475702519	0.000934819475702519	+1	PTEN,EPPK1,CDKN1B,PDGFRA,CDKN1A
GO:1903725	regulation of phospholipid metabolic process	0.000934819475702519	0.000934819475702519	+1	PIK3R1,FLT3,KIT,PDGFRA,FGFR3
GO:0060193	positive regulation of lipase activity	0.000934819475702519	0.000934819475702519	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0048701	embryonic cranial skeleton morphogenesis	0.0009488552705561363	0.0009488552705561363	+1	PDGFRA,FGFR2,TGFBR2
GO:0003214	cardiac left ventricle morphogenesis	0.0009488552705561363	0.0009488552705561363	+1	NOTCH1,SMAD4,TGFBR2
GO:0019221	cytokine-mediated signaling pathway	0.0009595732067786527	0.0009595732067786527	+1	TP53,PIK3CA,PIK3R1,GATA3,FLT3,RUNX1,CEBPA,AKT1,HGF,KIT,CCND1,SMAD4,CDKN1A,CBFB,PTPN11,LIFR
GO:0097696	receptor signaling pathway via STAT	0.0009917783972308845	0.0009917783972308845	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:1902749	regulation of cell cycle G2/M phase transition	0.000994780475562784	0.000994780475562784	+1	TP53,CDKN2A,NPM1,ATM,BRCA1,CCND1,CDKN1A,PPP2R1A
GO:0010507	negative regulation of autophagy	0.000994780475562784	0.000994780475562784	+1	PIK3CA,AKT1,HGF,MTOR,LRRK2
GO:0050679	positive regulation of epithelial cell proliferation	0.0010268046074665544	0.0010268046074665544	+1	EGFR,NRAS,AKT1,SOX9,TLR4,FGFR2,EGR3
GO:0007088	regulation of mitotic nuclear division	0.0010268046074665544	0.0010268046074665544	+1	APC,RB1,STAG2,ATM,ATRX,SMC1A,SMC3
GO:0035051	cardiocyte differentiation	0.0010514401165480046	0.0010514401165480046	+1	EGFR,NOTCH1,WT1,PDGFRA,SMAD4,SOX17
GO:0048705	skeletal system morphogenesis	0.0010514401165480046	0.0010514401165480046	+1	CTNNB1,SOX9,PDGFRA,FGFR2,FGFR3,TGFBR2
GO:0071285	cellular response to lithium ion	0.0010797628129300073	0.0010797628129300073	+1	CDH1,CDKN1B
GO:0033600	negative regulation of mammary gland epithelial cell proliferation	0.0010797628129300073	0.0010797628129300073	+1	GATA3,BRCA2
GO:0060445	branching involved in salivary gland morphogenesis	0.0010797628129300073	0.0010797628129300073	+1	HGF,FGFR2
GO:0010226	response to lithium ion	0.0010797628129300073	0.0010797628129300073	+1	CDH1,CDKN1B
GO:0003249	cell proliferation involved in heart valve morphogenesis	0.0010797628129300073	0.0010797628129300073	+1	NOTCH1,SMAD4
GO:0003250	regulation of cell proliferation involved in heart valve morphogenesis	0.0010797628129300073	0.0010797628129300073	+1	NOTCH1,SMAD4
GO:0097694	establishment of RNA localization to telomere	0.0010797628129300073	0.0010797628129300073	+1	ATM,ATR
GO:0097695	establishment of protein-containing complex localization to telomere	0.0010797628129300073	0.0010797628129300073	+1	ATM,ATR
GO:0046660	female sex differentiation	0.00108696155502037	0.00108696155502037	+1	TBX3,WT1,KIT,PDGFRA
GO:0072132	mesenchyme morphogenesis	0.00108696155502037	0.00108696155502037	+1	NOTCH1,SOX9,TGFBR2,SMAD2
GO:0051571	positive regulation of histone H3-K4 methylation	0.001140360130947711	0.001140360130947711	+1	CTNNB1,BRCA1,SMAD4
GO:0051546	keratinocyte migration	0.001140360130947711	0.001140360130947711	+1	PTEN,EPPK1,MTOR
GO:0010464	regulation of mesenchymal cell proliferation	0.001140360130947711	0.001140360130947711	+1	SOX9,FGFR2,TGFBR2
GO:0061213	positive regulation of mesonephros development	0.001140360130947711	0.001140360130947711	+1	GATA3,SOX9,WT1
GO:0032989	cellular component morphogenesis	0.0011689051153589056	0.0011689051153589056	+1	PIK3CA,PTEN,VHL,PIK3R1,RB1,CTNNB1,CDH1,ARHGAP35,EPHA3,LRRK2,KIT,PDGFRA,FGFR2,SMAD4,USP9X,SIN3A,PTPN11
GO:0072073	kidney epithelium development	0.0011856672384638644	0.0011856672384638644	+1	GATA3,CTNNB1,SOX9,WT1,FGFR2
GO:1902106	negative regulation of leukocyte differentiation	0.0011856672384638644	0.0011856672384638644	+1	CDKN2A,FBXW7,RUNX1,TLR4,CBFB
GO:0048704	embryonic skeletal system morphogenesis	0.0011914711707910963	0.0011914711707910963	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:0097327	response to antineoplastic agent	0.0011914711707910963	0.0011914711707910963	+1	CTNNB1,CDH1,ATRX,BRCA1
GO:0065004	protein-DNA complex assembly	0.0012096040460741584	0.0012096040460741584	+1	TP53,RB1,NPM1,SOX9,ATRX,TAF1,HIST1H2BD,ERCC2
GO:1902275	regulation of chromatin organization	0.0012109691580066758	0.0012109691580066758	+1	CTNNB1,ATRX,BRCA1,HIST1H1C,SMAD4,SIN3A,NSD1
GO:0051249	regulation of lymphocyte activation	0.0012251185239628521	0.0012251185239628521	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,ATM,TGFBR2,CBFB,PTPN11,MAPK8IP1
GO:0007368	determination of left/right symmetry	0.0012546225862227112	0.0012546225862227112	+1	NOTCH1,TBX3,TGFBR2,SOX17,SMAD2
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0012546225862227112	0.0012546225862227112	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:1903707	negative regulation of hemopoiesis	0.0012957711036173495	0.0012957711036173495	+1	CDKN2A,NOTCH1,FBXW7,RUNX1,TLR4,CBFB
GO:0060348	bone development	0.0012957711036173495	0.0012957711036173495	+1	TP53,FBXW7,SOX9,KIT,FGFR2,FGFR3
GO:0031056	regulation of histone modification	0.0012957711036173495	0.0012957711036173495	+1	CTNNB1,ATRX,BRCA1,SMAD4,SIN3A,NSD1
GO:0042246	tissue regeneration	0.0012985032571739255	0.0012985032571739255	+1	EPPK1,CDKN1B,ERBB4,CDKN1A
GO:0090183	regulation of kidney development	0.0012985032571739255	0.0012985032571739255	+1	GATA3,CTNNB1,SOX9,WT1
GO:0001889	liver development	0.0012985032571739255	0.0012985032571739255	+1	NF1,FBXW7,CEBPA,ARID5B
GO:0006511	ubiquitin-dependent protein catabolic process	0.0013091484087422711	0.0013091484087422711	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0042509	regulation of tyrosine phosphorylation of STAT protein	0.0013224478508140737	0.0013224478508140737	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0032481	positive regulation of type I interferon production	0.0013224478508140737	0.0013224478508140737	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:2001185	regulation of CD8-positive, alpha-beta T cell activation	0.0013509209819213659	0.0013509209819213659	+1	RUNX1,CBFB,MAPK8IP1
GO:0048485	sympathetic nervous system development	0.0013509209819213659	0.0013509209819213659	+1	NF1,GATA3,CTNNB1
GO:1903798	regulation of production of miRNAs involved in gene silencing by miRNA	0.0013509209819213659	0.0013509209819213659	+1	TP53,EGFR,NCOR1
GO:0071456	cellular response to hypoxia	0.001378438820696871	0.001378438820696871	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:0051783	regulation of nuclear division	0.001378438820696871	0.001378438820696871	+1	APC,RB1,STAG2,ATM,ATRX,SMC1A,SMC3
GO:0033036	macromolecule localization	0.0013882693963147216	0.0013882693963147216	+1	TP53,APC,EGFR,PIK3R1,GATA3,RB1,FBXW7,CTNNB1,KEAP1,CDH1,CTCF,BAP1,NPM1,IDH1,RPL22,EPHA3,AKT1,BRAF,AR,ATM,TLR4,U2AF1,ATRX,LRRK2,SETD2,FOXA2,USP9X,BRCA2,TGFBR2,ATR,SIN3A,RPL5,AXIN2,MIR142,RAD21
GO:0019941	modification-dependent protein catabolic process	0.0013890847768347689	0.0013890847768347689	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0030856	regulation of epithelial cell differentiation	0.0013978306021731725	0.0013978306021731725	+1	GATA3,CTNNB1,RUNX1,SOX9,CBFB,VEZF1
GO:0061008	hepaticobiliary system development	0.0014074111898520916	0.0014074111898520916	+1	NF1,FBXW7,CEBPA,ARID5B
GO:1903727	positive regulation of phospholipid metabolic process	0.0014074111898520916	0.0014074111898520916	+1	FLT3,KIT,PDGFRA,FGFR3
GO:0030335	positive regulation of cell migration	0.0014189554747561632	0.0014189554747561632	+1	APC,EGFR,GATA3,NOTCH1,AKT1,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:0010821	regulation of mitochondrion organization	0.0014189554747561632	0.0014189554747561632	+1	TP53,FBXW7,BAP1,AKT1,HGF,LRRK2,EP300
GO:1903829	positive regulation of cellular protein localization	0.001420111663825194	0.001420111663825194	+1	TP53,APC,EGFR,PIK3R1,FBXW7,CDH1,BAP1,EPHA3,AKT1
GO:0031929	TOR signaling	0.0014530901862009784	0.0014530901862009784	+1	PIK3CA,GATA3,STK11,AKT1,ATM,MTOR
GO:0060284	regulation of cell development	0.0014656802910198116	0.0014656802910198116	+1	PTEN,NF1,NOTCH1,FBXW7,CTNNB1,ARHGAP35,EPHA3,AKT1,SOX9,LRRK2,EP300,SMAD4,SIN3A,MIR142
GO:2000379	positive regulation of reactive oxygen species metabolic process	0.0014698036683728321	0.0014698036683728321	+1	TP53,AKT1,TLR4,TGFBR2,CDKN1A
GO:0032101	regulation of response to external stimulus	0.0014706612381820397	0.0014706612381820397	+1	PTEN,KRAS,GATA3,RB1,NOTCH1,MAP3K1,NRAS,CEBPA,EPPK1,CDKN1B,TLR4,PDGFRA,EP300,FOXA2,CDKN1A,SIN3A,PTPN11,MIR142
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	0.001512499980126411	0.001512499980126411	+1	TP53,VHL,NOTCH1,NFE2L2,EP300,TAF1
GO:0036294	cellular response to decreased oxygen levels	0.001512499980126411	0.001512499980126411	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:0048709	oligodendrocyte differentiation	0.0015261991962668786	0.0015261991962668786	+1	PTEN,NF1,NOTCH1,SOX9
GO:0001657	ureteric bud development	0.0015261991962668786	0.0015261991962668786	+1	GATA3,SOX9,WT1,FGFR2
GO:0003231	cardiac ventricle development	0.001547574077643346	0.001547574077643346	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0044728	DNA methylation or demethylation	0.001547574077643346	0.001547574077643346	+1	DNMT3A,WT1,TET2,ATRX,USP9X
GO:0008406	gonad development	0.001547574077643346	0.001547574077643346	+1	GATA3,SOX9,WT1,KIT,PDGFRA
GO:0034614	cellular response to reactive oxygen species	0.0015705979527314451	0.0015705979527314451	+1	EGFR,NFE2L2,AKT1,HGF,LRRK2,PDGFRA
GO:1902692	regulation of neuroblast proliferation	0.001573882074915374	0.001573882074915374	+1	NF1,CTNNB1,LRRK2
GO:0071480	cellular response to gamma radiation	0.001573882074915374	0.001573882074915374	+1	TP53,ATM,ATR
GO:0070920	regulation of production of small RNA involved in gene silencing by RNA	0.001573882074915374	0.001573882074915374	+1	TP53,EGFR,NCOR1
GO:0007420	brain development	0.0016035078898159142	0.0016035078898159142	+1	PTEN,NF1,CTNNB1,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,SIN3A,PTPN11
GO:0051270	regulation of cellular component movement	0.0016220423257859431	0.0016220423257859431	+1	PTEN,APC,NAV3,EGFR,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1,SOX9,ATM,HGF,ERBB4,MTOR,KIT,PDGFRA,ACVR1B
GO:0048667	cell morphogenesis involved in neuron differentiation	0.0016228936703640052	0.0016228936703640052	+1	PIK3CA,PTEN,PIK3R1,RB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:1903035	negative regulation of response to wounding	0.0016228936703640052	0.0016228936703640052	+1	PTEN,EPPK1,CDKN1B,PDGFRA,CDKN1A
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.0016228936703640052	0.0016228936703640052	+1	NOTCH1,STK11,EP300,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
GO:0007260	tyrosine phosphorylation of STAT protein	0.0016228936703640052	0.0016228936703640052	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
GO:0043632	modification-dependent macromolecule catabolic process	0.0016228936703640052	0.0016228936703640052	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0070741	response to interleukin-6	0.0016328748291071387	0.0016328748291071387	+1	CEBPA,SMAD4,FOXA2,PTPN11
GO:0072164	mesonephric tubule development	0.0016328748291071387	0.0016328748291071387	+1	GATA3,SOX9,WT1,FGFR2
GO:0072163	mesonephric epithelium development	0.0016328748291071387	0.0016328748291071387	+1	GATA3,SOX9,WT1,FGFR2
GO:0035196	production of miRNAs involved in gene silencing by miRNA	0.0016328748291071387	0.0016328748291071387	+1	TP53,EGFR,NCOR1,SMAD2
GO:0002011	morphogenesis of an epithelial sheet	0.0016328748291071387	0.0016328748291071387	+1	PTEN,NOTCH1,ARHGAP35,MTOR
GO:0045834	positive regulation of lipid metabolic process	0.00168319384712743	0.00168319384712743	+1	FLT3,AKT1,MTOR,KIT,PDGFRA,FGFR3
GO:0045927	positive regulation of growth	0.001696159371045545	0.001696159371045545	+1	EGFR,NOTCH1,AKT1,WT1,ERBB4,FGFR2,H3F3C
GO:1903321	negative regulation of protein modification by small protein conjugation or removal	0.0016997798157822408	0.0016997798157822408	+1	CDKN2A,CTNNB1,AKT1,TAF1,RPL5
GO:0045137	development of primary sexual characteristics	0.0016997798157822408	0.0016997798157822408	+1	GATA3,SOX9,WT1,KIT,PDGFRA
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	0.0016997798157822408	0.0016997798157822408	+1	NOTCH1,FLT3,ERBB4,KIT,FGFR3
GO:0001947	heart looping	0.001775092335297343	0.001775092335297343	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:0009855	determination of bilateral symmetry	0.001800323616881535	0.001800323616881535	+1	NOTCH1,TBX3,TGFBR2,SOX17,SMAD2
GO:0031668	cellular response to extracellular stimulus	0.0018076050293859382	0.0018076050293859382	+1	TP53,ARHGAP35,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:0062009	secondary palate development	0.0018167938797993281	0.0018167938797993281	+1	SMAD4,TGFBR2,SMAD2
GO:0050680	negative regulation of epithelial cell proliferation	0.0018167938797993281	0.0018167938797993281	+1	NF1,GATA3,FBXW7,EPPK1,SOX9,BRCA2
GO:0061217	regulation of mesonephros development	0.0018167938797993281	0.0018167938797993281	+1	GATA3,SOX9,WT1
GO:0070200	establishment of protein localization to telomere	0.0018167938797993281	0.0018167938797993281	+1	ATM,BRCA2,ATR
GO:1901575	organic substance catabolic process	0.001821113566975979	0.001821113566975979	+1	TP53,PTEN,APC,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,RPL22,CEBPA,AKT1,ATM,CDKN1B,MTOR,TET2,LRRK2,CHEK2,EP300,USP9X,TAF1,PPP2R1A,TBL1XR1,NCOR1,RPL5,SPOP,AXIN2
GO:0032446	protein modification by small protein conjugation	0.0018585482663775904	0.0018585482663775904	+1	PTEN,VHL,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,AKT1,BRCA1,LRRK2,USP9X,TAF1,CBFB,HIST1H2BD,RPL5
GO:0060740	prostate gland epithelium morphogenesis	0.0018813583021629833	0.0018813583021629833	+1	SOX9,FGFR2
GO:0060736	prostate gland growth	0.0018813583021629833	0.0018813583021629833	+1	SOX9,FGFR2
GO:0048853	forebrain morphogenesis	0.0018813583021629833	0.0018813583021629833	+1	PTEN,NF1
GO:0035522	monoubiquitinated histone H2A deubiquitination	0.0018813583021629833	0.0018813583021629833	+1	BAP1,ASXL1
GO:2000435	negative regulation of protein neddylation	0.0018813583021629833	0.0018813583021629833	+1	CDKN2A,RPL5
GO:0030916	otic vesicle formation	0.0018813583021629833	0.0018813583021629833	+1	SOX9,FGFR2
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	0.0018813583021629833	0.0018813583021629833	+1	TP53,ATM,BRCA1,CHEK2,EP300
GO:0003206	cardiac chamber morphogenesis	0.0018813583021629833	0.0018813583021629833	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	0.0018813583021629833	0.0018813583021629833	+1	RUNX1,CBFB
GO:0043620	regulation of DNA-templated transcription in response to stress	0.0018813583021629833	0.0018813583021629833	+1	TP53,VHL,NOTCH1,NFE2L2,EP300,TAF1
GO:0035521	monoubiquitinated histone deubiquitination	0.0018813583021629833	0.0018813583021629833	+1	BAP1,ASXL1
GO:0009799	specification of symmetry	0.0018813583021629833	0.0018813583021629833	+1	NOTCH1,TBX3,TGFBR2,SOX17,SMAD2
GO:2000147	positive regulation of cell motility	0.0018813583021629833	0.0018813583021629833	+1	APC,EGFR,GATA3,NOTCH1,AKT1,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:2000793	cell proliferation involved in heart valve development	0.0018813583021629833	0.0018813583021629833	+1	NOTCH1,SMAD4
GO:0071600	otic vesicle morphogenesis	0.0018813583021629833	0.0018813583021629833	+1	SOX9,FGFR2
GO:0007219	Notch signaling pathway	0.0019335425625769825	0.0019335425625769825	+1	EGFR,NOTCH1,FBXW7,AKT1,ELF3,EP300
GO:0007159	leukocyte cell-cell adhesion	0.0019428545452050772	0.0019428545452050772	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0051641	cellular localization	0.001946487159933966	0.001946487159933966	+1	TP53,PTEN,APC,EGFR,PIK3R1,RB1,FBXW7,CTNNB1,CDH1,CTCF,BAP1,NPM1,IDH1,RPL22,EPHA3,AKT1,BRAF,AR,PIK3CG,ATM,U2AF1,ATRX,LRRK2,KIT,SETD2,FOXA2,USP9X,BRCA2,PPP2R1A,ATR,SIN3A,RPL5,AXIN2,RAD21
GO:1904894	positive regulation of receptor signaling pathway via STAT	0.0019557572017837995	0.0019557572017837995	+1	NOTCH1,FLT3,ERBB4,KIT,FGFR3
GO:0007626	locomotory behavior	0.0020397186105549684	0.0020397186105549684	+1	PTEN,MTOR,FOXA2,NCOR1
GO:0071453	cellular response to oxygen levels	0.002072108442247369	0.002072108442247369	+1	TP53,VHL,NOTCH1,NFE2L2,AJUBA,MTOR,EP300
GO:2001234	negative regulation of apoptotic signaling pathway	0.002072108442247369	0.002072108442247369	+1	RB1,NFE2L2,AKT1,AR,HGF,BRCA1,LRRK2
GO:0032925	regulation of activin receptor signaling pathway	0.002072108442247369	0.002072108442247369	+1	ACVR1B,ACVR2A,SMAD2
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	0.002072108442247369	0.002072108442247369	+1	EGFR,AKT1,CCND1
GO:0006310	DNA recombination	0.0020866787134852342	0.0020866787134852342	+1	ATM,BRCA1,POLQ,HIST1H1C,SETD2,BRCA2,RAD21,ERCC2
GO:0030098	lymphocyte differentiation	0.0020866787134852342	0.0020866787134852342	+1	CDKN2A,GATA3,FLT3,RUNX1,ATM,KIT,TGFBR2,CBFB
GO:0048666	neuron development	0.00213832671204098	0.00213832671204098	+1	PIK3CA,PTEN,PIK3R1,RB1,CTNNB1,ARHGAP35,RUNX1,EPHA3,AKT1,LRRK2,EP300,FGFR2,USP9X,SIN3A,PTPN11
GO:1903076	regulation of protein localization to plasma membrane	0.0021673261248252177	0.0021673261248252177	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0001823	mesonephros development	0.0021777409383698324	0.0021777409383698324	+1	GATA3,SOX9,WT1,FGFR2
GO:0060420	regulation of heart growth	0.0021777409383698324	0.0021777409383698324	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0043388	positive regulation of DNA binding	0.0021777409383698324	0.0021777409383698324	+1	GATA3,RB1,CTNNB1,EP300
GO:0070918	production of small RNA involved in gene silencing by RNA	0.0021777409383698324	0.0021777409383698324	+1	TP53,EGFR,NCOR1,SMAD2
GO:0031050	dsRNA processing	0.0021777409383698324	0.0021777409383698324	+1	TP53,EGFR,NCOR1,SMAD2
GO:0008584	male gonad development	0.0021777409383698324	0.0021777409383698324	+1	GATA3,SOX9,WT1,KIT
GO:0006383	transcription by RNA polymerase III	0.0021777409383698324	0.0021777409383698324	+1	CEBPA,AR,MTOR,BRCA1
GO:0070925	organelle assembly	0.0022071428560621093	0.0022071428560621093	+1	PTEN,NOTCH1,ARHGAP35,NPM1,STAG2,BRCA1,LRRK2,CHEK2,PDGFRA,SMAD4,PPP2R1A,SMC1A,SMC3,NCOR1,RPL5
GO:0060322	head development	0.0022155187474252732	0.0022155187474252732	+1	PTEN,NF1,CTNNB1,ERBB4,LRRK2,FGFR2,TGFBR2,TAF1,SIN3A,PTPN11
GO:0036037	CD8-positive, alpha-beta T cell activation	0.0023256813762026975	0.0023256813762026975	+1	RUNX1,CBFB,MAPK8IP1
GO:0110111	negative regulation of animal organ morphogenesis	0.0023256813762026975	0.0023256813762026975	+1	GATA3,NOTCH1,FBXW7
GO:1900408	negative regulation of cellular response to oxidative stress	0.0023256813762026975	0.0023256813762026975	+1	NFE2L2,AKT1,HGF,LRRK2
GO:0061919	process utilizing autophagic mechanism	0.0023256813762026975	0.0023256813762026975	+1	TP53,PIK3CA,FBXW7,KEAP1,STK11,AKT1,ATM,HGF,MTOR,LRRK2,EP300
GO:0003181	atrioventricular valve morphogenesis	0.0023256813762026975	0.0023256813762026975	+1	NOTCH1,SMAD4,TGFBR2
GO:1903202	negative regulation of oxidative stress-induced cell death	0.0023256813762026975	0.0023256813762026975	+1	NFE2L2,AKT1,HGF,LRRK2
GO:0046546	development of primary male sexual characteristics	0.0023256813762026975	0.0023256813762026975	+1	GATA3,SOX9,WT1,KIT
GO:0060993	kidney morphogenesis	0.0023256813762026975	0.0023256813762026975	+1	GATA3,SOX9,WT1,LRRK2
GO:1904666	regulation of ubiquitin protein ligase activity	0.0023256813762026975	0.0023256813762026975	+1	PTEN,CDKN2A,RPL5
GO:0006914	autophagy	0.0023256813762026975	0.0023256813762026975	+1	TP53,PIK3CA,FBXW7,KEAP1,STK11,AKT1,ATM,HGF,MTOR,LRRK2,EP300
GO:0043009	chordate embryonic development	0.0023256813762026975	0.0023256813762026975	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:0048806	genitalia development	0.0023256813762026975	0.0023256813762026975	+1	TBX3,WT1,PTPN11
GO:0001570	vasculogenesis	0.0023256813762026975	0.0023256813762026975	+1	NOTCH1,WT1,TGFBR2,SOX17
GO:0051569	regulation of histone H3-K4 methylation	0.0023256813762026975	0.0023256813762026975	+1	CTNNB1,BRCA1,SMAD4
GO:0003143	embryonic heart tube morphogenesis	0.0023256813762026975	0.0023256813762026975	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:0010463	mesenchymal cell proliferation	0.0023256813762026975	0.0023256813762026975	+1	SOX9,FGFR2,TGFBR2
GO:0051272	positive regulation of cellular component movement	0.0023256813762026975	0.0023256813762026975	+1	APC,EGFR,GATA3,NOTCH1,AKT1,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:0009798	axis specification	0.0023256813762026975	0.0023256813762026975	+1	TBX3,WT1,FOXA2,SMAD2
GO:0061371	determination of heart left/right asymmetry	0.0023256813762026975	0.0023256813762026975	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:0120163	negative regulation of cold-induced thermogenesis	0.0023256813762026975	0.0023256813762026975	+1	RB1,NOTCH1,STK11,TLR4
GO:0060560	developmental growth involved in morphogenesis	0.002362519123747919	0.002362519123747919	+1	NOTCH1,CTNNB1,SOX9,FGFR2,USP9X,SIN3A
GO:2001251	negative regulation of chromosome organization	0.0024585620010331224	0.0024585620010331224	+1	APC,ATM,ATRX,BRCA1,HIST1H1C,SIN3A
GO:0051438	regulation of ubiquitin-protein transferase activity	0.002482800641974179	0.002482800641974179	+1	PTEN,CDKN2A,FBXW7,RPL5
GO:0071260	cellular response to mechanical stimulus	0.002482800641974179	0.002482800641974179	+1	MAP3K1,MAP2K4,SOX9,TLR4
GO:0051099	positive regulation of binding	0.002547967340398796	0.002547967340398796	+1	GATA3,RB1,CTNNB1,LRRK2,EP300,TAF1
GO:0030168	platelet activation	0.002547967340398796	0.002547967340398796	+1	PIK3CA,PIK3R1,PIK3CG,TLR4,PDGFRA,PTPN11
GO:0071772	response to BMP	0.0026380882834620718	0.0026380882834620718	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0071773	cellular response to BMP stimulus	0.0026380882834620718	0.0026380882834620718	+1	NOTCH1,SOX9,SMAD4,USP9X,ACVR2A,SMAD2
GO:0071248	cellular response to metal ion	0.0026380882834620718	0.0026380882834620718	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:1902808	positive regulation of cell cycle G1/S phase transition	0.0026380882834620718	0.0026380882834620718	+1	EGFR,AKT1,CCND1,EZH2
GO:0000578	embryonic axis specification	0.0026380882834620718	0.0026380882834620718	+1	TBX3,WT1,SMAD2
GO:0040017	positive regulation of locomotion	0.0026380882834620718	0.0026380882834620718	+1	APC,EGFR,GATA3,NOTCH1,AKT1,SOX9,ATM,HGF,MTOR,KIT,PDGFRA,ACVR1B
GO:1902883	negative regulation of response to oxidative stress	0.0026380882834620718	0.0026380882834620718	+1	NFE2L2,AKT1,HGF,LRRK2
GO:0043032	positive regulation of macrophage activation	0.0026380882834620718	0.0026380882834620718	+1	CEBPA,TLR4,MIR142
GO:0060411	cardiac septum morphogenesis	0.0026380882834620718	0.0026380882834620718	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
GO:0072080	nephron tubule development	0.0026380882834620718	0.0026380882834620718	+1	GATA3,CTNNB1,SOX9,WT1
GO:2000637	positive regulation of gene silencing by miRNA	0.0026380882834620718	0.0026380882834620718	+1	TP53,EGFR,AJUBA
GO:0007064	mitotic sister chromatid cohesion	0.0026380882834620718	0.0026380882834620718	+1	RB1,ATRX,SMC1A
GO:1901673	regulation of mitotic spindle assembly	0.0026380882834620718	0.0026380882834620718	+1	STAG2,SMC1A,SMC3
GO:0007610	behavior	0.0026631046277336796	0.0026631046277336796	+1	TP53,PTEN,EGFR,NF1,MTOR,LRRK2,FOXA2,NCOR1
GO:0030219	megakaryocyte differentiation	0.002672921476469145	0.002672921476469145	+1	RUNX1,KIT,EP300,CBFB,SIN3A
GO:0033157	regulation of intracellular protein transport	0.002692917706555095	0.002692917706555095	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,LRRK2,SETD2
GO:0031175	neuron projection development	0.0026989766172477426	0.0026989766172477426	+1	PIK3CA,PTEN,PIK3R1,RB1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,EP300,FGFR2,USP9X,SIN3A,PTPN11
GO:0050767	regulation of neurogenesis	0.0027037272311297407	0.0027037272311297407	+1	PTEN,NF1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,SOX9,LRRK2,EP300,SIN3A,MIR142
GO:0045321	leukocyte activation	0.0027222552675533773	0.0027222552675533773	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,NRAS,IDH1,CEBPA,AKT1,PIK3CG,ATM,TLR4,KIT,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:0048514	blood vessel morphogenesis	0.0027440525443762883	0.0027440525443762883	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0031295	T cell costimulation	0.002800468985102098	0.002800468985102098	+1	PIK3CA,PIK3R1,AKT1,PTPN11
GO:2000434	regulation of protein neddylation	0.002800468985102098	0.002800468985102098	+1	CDKN2A,RPL5
GO:0048706	embryonic skeletal system development	0.002800468985102098	0.002800468985102098	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
GO:0003149	membranous septum morphogenesis	0.002800468985102098	0.002800468985102098	+1	FGFR2,TGFBR2
GO:0060729	intestinal epithelial structure maintenance	0.002800468985102098	0.002800468985102098	+1	SOX9,TLR4
GO:1903223	positive regulation of oxidative stress-induced neuron death	0.002800468985102098	0.002800468985102098	+1	FBXW7,TLR4
GO:0003160	endocardium morphogenesis	0.002800468985102098	0.002800468985102098	+1	NOTCH1,SOX17
GO:2000020	positive regulation of male gonad development	0.002800468985102098	0.002800468985102098	+1	SOX9,WT1
GO:0061326	renal tubule development	0.002800468985102098	0.002800468985102098	+1	GATA3,CTNNB1,SOX9,WT1
GO:1903078	positive regulation of protein localization to plasma membrane	0.002800468985102098	0.002800468985102098	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:1902498	regulation of protein autoubiquitination	0.002800468985102098	0.002800468985102098	+1	LRRK2,TAF1
GO:2000617	positive regulation of histone H3-K9 acetylation	0.002800468985102098	0.002800468985102098	+1	BRCA1,SMAD4
GO:0006102	isocitrate metabolic process	0.002800468985102098	0.002800468985102098	+1	IDH1,IDH2
GO:0030539	male genitalia development	0.002800468985102098	0.002800468985102098	+1	TBX3,WT1
GO:0060512	prostate gland morphogenesis	0.002800468985102098	0.002800468985102098	+1	SOX9,FGFR2
GO:0048873	homeostasis of number of cells within a tissue	0.002800468985102098	0.002800468985102098	+1	NOTCH1,SOX9
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.002800468985102098	0.002800468985102098	+1	NOTCH1,NFE2L2
GO:0043254	regulation of protein-containing complex assembly	0.0028157437213207894	0.0028157437213207894	+1	TP53,NAV3,RB1,AJUBA,ATM,TLR4,EP300,ATR,PTPN11,ERCC2
GO:0048738	cardiac muscle tissue development	0.0028491397239456036	0.0028491397239456036	+1	NOTCH1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0000902	cell morphogenesis	0.002916470594115784	0.002916470594115784	+1	PIK3CA,PTEN,VHL,PIK3R1,RB1,CTNNB1,CDH1,ARHGAP35,EPHA3,LRRK2,KIT,FGFR2,USP9X,SIN3A,PTPN11
GO:0060148	positive regulation of posttranscriptional gene silencing	0.002916470594115784	0.002916470594115784	+1	TP53,EGFR,AJUBA
GO:0003171	atrioventricular valve development	0.002916470594115784	0.002916470594115784	+1	NOTCH1,SMAD4,TGFBR2
GO:0048546	digestive tract morphogenesis	0.002916470594115784	0.002916470594115784	+1	PDGFRA,FGFR2,SOX17
GO:1904031	positive regulation of cyclin-dependent protein kinase activity	0.002916470594115784	0.002916470594115784	+1	EGFR,AKT1,CCND1
GO:0030513	positive regulation of BMP signaling pathway	0.002916470594115784	0.002916470594115784	+1	NOTCH1,SMAD4,SMAD2
GO:0140014	mitotic nuclear division	0.0029314383428319943	0.0029314383428319943	+1	APC,RB1,STAG2,ATM,ATRX,CHEK2,SMC1A,SMC3
GO:1903708	positive regulation of hemopoiesis	0.0029343733591256304	0.0029343733591256304	+1	GATA3,RUNX1,TGFBR2,CBFB,ACVR1B,ACVR2A
GO:0031294	lymphocyte costimulation	0.002941352107836128	0.002941352107836128	+1	PIK3CA,PIK3R1,AKT1,PTPN11
GO:0043966	histone H3 acetylation	0.002941352107836128	0.002941352107836128	+1	BRCA1,SMAD4,BRCA2,SIN3A
GO:0035050	embryonic heart tube development	0.002941352107836128	0.002941352107836128	+1	NOTCH1,TBX3,TGFBR2,SOX17
GO:0060191	regulation of lipase activity	0.0029830473479406944	0.0029830473479406944	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
GO:0097305	response to alcohol	0.0029830473479406944	0.0029830473479406944	+1	CTNNB1,CDH1,BRCA1,TGFBR2,SMAD2
GO:0072006	nephron development	0.0029830473479406944	0.0029830473479406944	+1	GATA3,CTNNB1,SOX9,WT1,PDGFRA
GO:0009896	positive regulation of catabolic process	0.002999957374726391	0.002999957374726391	+1	PTEN,APC,FBXW7,KEAP1,NFE2L2,STK11,CEBPA,CDKN1B,LRRK2,TAF1
GO:0071560	cellular response to transforming growth factor beta stimulus	0.0032044521259623534	0.0032044521259623534	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,SMAD2
GO:1901032	negative regulation of response to reactive oxygen species	0.003269555352043771	0.003269555352043771	+1	NFE2L2,HGF,LRRK2
GO:0072210	metanephric nephron development	0.003269555352043771	0.003269555352043771	+1	SOX9,WT1,PDGFRA
GO:1903206	negative regulation of hydrogen peroxide-induced cell death	0.003269555352043771	0.003269555352043771	+1	NFE2L2,HGF,LRRK2
GO:0009056	catabolic process	0.003269555352043771	0.003269555352043771	+1	TP53,PIK3CA,PTEN,APC,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,RPL22,STK11,CEBPA,AKT1,ATM,CDKN1B,HGF,MTOR,TET2,LRRK2,CHEK2,EP300,USP9X,TAF1,PPP2R1A,TBL1XR1,NCOR1,RPL5,SPOP,AXIN2
GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus	0.003269555352043771	0.003269555352043771	+1	STK11,EP300,SMAD4
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	0.003269555352043771	0.003269555352043771	+1	STK11,EP300,SMAD4
GO:1905332	positive regulation of morphogenesis of an epithelium	0.003269555352043771	0.003269555352043771	+1	GATA3,SOX9,MTOR
GO:0009792	embryo development ending in birth or egg hatching	0.0032737639207271138	0.0032737639207271138	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
GO:0042493	response to drug	0.003299630651625251	0.003299630651625251	+1	TP53,CTNNB1,CDH1,NFE2L2,SOX9,HGF,ATRX,BRCA1,LRRK2,CCND1,TGFBR2,TAF1
GO:0044257	cellular protein catabolic process	0.003312852012641367	0.003312852012641367	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,CHEK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0030900	forebrain development	0.0033430496191880843	0.0033430496191880843	+1	PTEN,NF1,ERBB4,LRRK2,FGFR2,SIN3A
GO:0006928	movement of cell or subcellular component	0.0033540403055134743	0.0033540403055134743	+1	PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CDH1,ARHGAP35,EPHA3,AKT1,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,LRRK2,KIT,PDGFRA,USP9X,PTPN11,ACVR1B,EGR3
GO:1901216	positive regulation of neuron death	0.003573484939816279	0.003573484939816279	+1	NF1,FBXW7,CTNNB1,TLR4
GO:0045445	myoblast differentiation	0.003573484939816279	0.003573484939816279	+1	RB1,NOTCH1,TBX3,SOX9
GO:0010827	regulation of glucose transmembrane transport	0.003573484939816279	0.003573484939816279	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0042592	homeostatic process	0.0035763777617316295	0.0035763777617316295	+1	APC,NF1,PIK3R1,RB1,NOTCH1,FBXW7,FLT3,NFE2L2,STK11,CEBPA,AKT1,SOX9,ATM,TLR4,ATRX,LRRK2,KIT,PDGFRA,SMAD4,FOXA2,ATR,ACVR1B,ACVR2A
GO:0000302	response to reactive oxygen species	0.0035763777617316295	0.0035763777617316295	+1	EGFR,NFE2L2,AKT1,HGF,LRRK2,PDGFRA
GO:0048285	organelle fission	0.0035872293549679534	0.0035872293549679534	+1	APC,RB1,STAG2,ATM,ATRX,LRRK2,CHEK2,SMC1A,SMC3,RAD21
GO:0001525	angiogenesis	0.003625148122687672	0.003625148122687672	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0010332	response to gamma radiation	0.003648202734022039	0.003648202734022039	+1	TP53,ATM,ATR
GO:0003148	outflow tract septum morphogenesis	0.003648202734022039	0.003648202734022039	+1	FGFR2,SMAD4,TGFBR2
GO:1904888	cranial skeletal system development	0.003648202734022039	0.003648202734022039	+1	PDGFRA,FGFR2,TGFBR2
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.003648202734022039	0.003648202734022039	+1	FBXW7,NFE2L2,AKT1
GO:0010675	regulation of cellular carbohydrate metabolic process	0.0036988465534584227	0.0036988465534584227	+1	TP53,AKT1,EP300,FOXA2,NCOR1
GO:0051225	spindle assembly	0.0036988465534584227	0.0036988465534584227	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:0010035	response to inorganic substance	0.003710978185800066	0.003710978185800066	+1	EGFR,CDH1,NFE2L2,AKT1,BRAF,CDKN1B,HGF,ATRX,LRRK2
GO:0044262	cellular carbohydrate metabolic process	0.0037201257472684567	0.0037201257472684567	+1	TP53,PTEN,AKT1,BRAF,EP300,FOXA2,NCOR1
GO:0071559	response to transforming growth factor beta	0.0037201257472684567	0.0037201257472684567	+1	STK11,SOX9,EP300,SMAD4,USP9X,TGFBR2,SMAD2
GO:0090307	mitotic spindle assembly	0.0037705823145796845	0.0037705823145796845	+1	STAG2,CHEK2,SMC1A,SMC3
GO:2000377	regulation of reactive oxygen species metabolic process	0.003791203394276284	0.003791203394276284	+1	TP53,AKT1,TLR4,BRCA1,TGFBR2,CDKN1A
GO:1901565	organonitrogen compound catabolic process	0.0038522968676748546	0.0038522968676748546	+1	PTEN,APC,EGFR,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,CDKN1B,MTOR,TET2,LRRK2,CHEK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.0038522968676748546	0.0038522968676748546	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
GO:0071599	otic vesicle development	0.003882576033213055	0.003882576033213055	+1	SOX9,FGFR2
GO:0048755	branching morphogenesis of a nerve	0.003882576033213055	0.003882576033213055	+1	LRRK2,FGFR2
GO:1905178	regulation of cardiac muscle tissue regeneration	0.003882576033213055	0.003882576033213055	+1	CDKN1B,CDKN1A
GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation	0.003882576033213055	0.003882576033213055	+1	RUNX1,CBFB
GO:2000018	regulation of male gonad development	0.003882576033213055	0.003882576033213055	+1	SOX9,WT1
GO:1905941	positive regulation of gonad development	0.003882576033213055	0.003882576033213055	+1	SOX9,WT1
GO:1905323	telomerase holoenzyme complex assembly	0.003882576033213055	0.003882576033213055	+1	ATM,ATR
GO:1901723	negative regulation of cell proliferation involved in kidney development	0.003882576033213055	0.003882576033213055	+1	GATA3,WT1
GO:2000739	regulation of mesenchymal stem cell differentiation	0.003882576033213055	0.003882576033213055	+1	SOX9,PDGFRA
GO:0007435	salivary gland morphogenesis	0.003882576033213055	0.003882576033213055	+1	HGF,FGFR2
GO:0008340	determination of adult lifespan	0.003882576033213055	0.003882576033213055	+1	TP53,LRRK2
GO:1905634	regulation of protein localization to chromatin	0.003882576033213055	0.003882576033213055	+1	RB1,SETD2
GO:2001020	regulation of response to DNA damage stimulus	0.003882576033213055	0.003882576033213055	+1	EGFR,ATM,BRCA1,POLQ,SETD2,ATR,AXIN2
GO:0036302	atrioventricular canal development	0.003882576033213055	0.003882576033213055	+1	SMAD4,PTPN11
GO:0048812	neuron projection morphogenesis	0.003904228892851631	0.003904228892851631	+1	PIK3CA,PTEN,PIK3R1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:0001775	cell activation	0.003904228892851631	0.003904228892851631	+1	PIK3CA,PIK3R1,CDKN2A,GATA3,FLT3,RUNX1,NRAS,IDH1,CEBPA,AKT1,PIK3CG,ATM,TLR4,KIT,PDGFRA,TGFBR2,CBFB,PTPN11,MAPK8IP1,MIR142
GO:0009612	response to mechanical stimulus	0.003939437577101045	0.003939437577101045	+1	MAP3K1,MAP2K4,SOX9,TLR4,KIT
GO:0055024	regulation of cardiac muscle tissue development	0.003939437577101045	0.003939437577101045	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:1904377	positive regulation of protein localization to cell periphery	0.003939437577101045	0.003939437577101045	+1	EGFR,PIK3R1,EPHA3,AKT1
GO:0006304	DNA modification	0.003939437577101045	0.003939437577101045	+1	DNMT3A,WT1,TET2,ATRX,USP9X
GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	0.003939437577101045	0.003939437577101045	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
GO:0048645	animal organ formation	0.003964574858005014	0.003964574858005014	+1	WT1,FGFR2,SOX17
GO:2001039	negative regulation of cellular response to drug	0.003964574858005014	0.003964574858005014	+1	NFE2L2,HGF,LRRK2
GO:2000144	positive regulation of DNA-templated transcription, initiation	0.003964574858005014	0.003964574858005014	+1	TP53,CTNNB1,TAF1
GO:0048483	autonomic nervous system development	0.003964574858005014	0.003964574858005014	+1	NF1,GATA3,CTNNB1
GO:0071168	protein localization to chromatin	0.003964574858005014	0.003964574858005014	+1	RB1,SETD2,RAD21
GO:0002684	positive regulation of immune system process	0.004057709175099099	0.004057709175099099	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,CEBPA,AKT1,TLR4,EP300,TGFBR2,CBFB,SIN3A,PTPN11,ACVR1B,ACVR2A,MIR142
GO:0060968	regulation of gene silencing	0.00408286362901659	0.00408286362901659	+1	TP53,EGFR,AJUBA,HIST1H1C,SIN3A,NCOR1
GO:1904375	regulation of protein localization to cell periphery	0.0040902552283780666	0.0040902552283780666	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0060419	heart growth	0.004157283803717247	0.004157283803717247	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0001568	blood vessel development	0.004157283803717247	0.004157283803717247	+1	NF1,NOTCH1,CTNNB1,RUNX1,AKT1,WT1,BRCA1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
GO:0045582	positive regulation of T cell differentiation	0.004433454894202518	0.004433454894202518	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0051603	proteolysis involved in cellular protein catabolic process	0.0045234204799607155	0.0045234204799607155	+1	PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,USP9X,TAF1,TBL1XR1,RPL5,SPOP
GO:0002768	immune response-regulating cell surface receptor signaling pathway	0.004544380379946821	0.004544380379946821	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,MAP2K4,KIT,EP300,CBFB
GO:0007409	axonogenesis	0.004587841073924752	0.004587841073924752	+1	PIK3CA,PTEN,PIK3R1,ARHGAP35,EPHA3,FGFR2,USP9X,SIN3A,PTPN11
GO:0007265	Ras protein signal transduction	0.00467976254649631	0.00467976254649631	+1	TP53,KRAS,NF1,CDKN2A,RB1,NOTCH1,ARHGAP35,NRAS,CDKN1A
GO:0120039	plasma membrane bounded cell projection morphogenesis	0.0046857737865591735	0.0046857737865591735	+1	PIK3CA,PTEN,PIK3R1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:0048565	digestive tract development	0.004692449918875602	0.004692449918875602	+1	KIT,PDGFRA,FGFR2,SOX17
GO:0035270	endocrine system development	0.004692449918875602	0.004692449918875602	+1	NF1,AKT1,WT1,FOXA2
GO:0060537	muscle tissue development	0.004725766056436892	0.004725766056436892	+1	NF1,NOTCH1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:0120036	plasma membrane bounded cell projection organization	0.004781588827322504	0.004781588827322504	+1	PIK3CA,PTEN,APC,NAV3,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,KIT,EP300,FGFR2,USP9X,PPP2R1A,SIN3A,PTPN11
GO:0045580	regulation of T cell differentiation	0.004828777311419454	0.004828777311419454	+1	CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:0046326	positive regulation of glucose import	0.004859911174637349	0.004859911174637349	+1	PIK3R1,AKT1,PTPN11
GO:0048858	cell projection morphogenesis	0.004859911174637349	0.004859911174637349	+1	PIK3CA,PTEN,PIK3R1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:0045922	negative regulation of fatty acid metabolic process	0.004859911174637349	0.004859911174637349	+1	AKT1,BRCA1,NCOR1
GO:0090169	regulation of spindle assembly	0.004859911174637349	0.004859911174637349	+1	STAG2,SMC1A,SMC3
GO:1903205	regulation of hydrogen peroxide-induced cell death	0.004859911174637349	0.004859911174637349	+1	NFE2L2,HGF,LRRK2
GO:0070199	establishment of protein localization to chromosome	0.004859911174637349	0.004859911174637349	+1	ATM,BRCA2,ATR
GO:0010632	regulation of epithelial cell migration	0.004859911174637349	0.004859911174637349	+1	PTEN,NF1,GATA3,NOTCH1,AKT1,EPPK1,SOX9,MTOR
GO:0060045	positive regulation of cardiac muscle cell proliferation	0.004859911174637349	0.004859911174637349	+1	NOTCH1,ERBB4,FGFR2
GO:0031214	biomineral tissue development	0.004990939112798747	0.004990939112798747	+1	NOTCH1,SOX9,FGFR2,FGFR3,ACVR2A
GO:0110148	biomineralization	0.004990939112798747	0.004990939112798747	+1	NOTCH1,SOX9,FGFR2,FGFR3,ACVR2A
GO:0034329	cell junction assembly	0.005064005361839642	0.005064005361839642	+1	PTEN,APC,CTNNB1,CDH1,RUNX1,EPHA3,CBFB
GO:0007431	salivary gland development	0.0051347300536091645	0.0051347300536091645	+1	HGF,FGFR2
GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	0.0051347300536091645	0.0051347300536091645	+1	NOTCH1,TGFBR2
GO:0071371	cellular response to gonadotropin stimulus	0.0051347300536091645	0.0051347300536091645	+1	NOTCH1,WT1
GO:1903689	regulation of wound healing, spreading of epidermal cells	0.0051347300536091645	0.0051347300536091645	+1	PTEN,MTOR
GO:0002327	immature B cell differentiation	0.0051347300536091645	0.0051347300536091645	+1	ATM,KIT
GO:0060602	branch elongation of an epithelium	0.0051347300536091645	0.0051347300536091645	+1	SOX9,FGFR2
GO:0048715	negative regulation of oligodendrocyte differentiation	0.0051347300536091645	0.0051347300536091645	+1	NF1,NOTCH1
GO:0003190	atrioventricular valve formation	0.0051347300536091645	0.0051347300536091645	+1	NOTCH1,SMAD4
GO:0071481	cellular response to X-ray	0.0051347300536091645	0.0051347300536091645	+1	GATA3,ATM
GO:0003158	endothelium development	0.005145617605553743	0.005145617605553743	+1	NOTCH1,CTNNB1,SMAD4,SOX17,VEZF1
GO:0043583	ear development	0.005145617605553743	0.005145617605553743	+1	GATA3,SOX9,FGFR2,PTPN11
GO:0030217	T cell differentiation	0.005145617605553743	0.005145617605553743	+1	CDKN2A,GATA3,RUNX1,KIT,TGFBR2,CBFB
GO:0018107	peptidyl-threonine phosphorylation	0.005145617605553743	0.005145617605553743	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
GO:0032526	response to retinoic acid	0.005145617605553743	0.005145617605553743	+1	EPHA3,SOX9,ATM,ASXL1
GO:0055123	digestive system development	0.005145617605553743	0.005145617605553743	+1	KIT,PDGFRA,FGFR2,SOX17
GO:0045815	positive regulation of gene expression, epigenetic	0.005145617605553743	0.005145617605553743	+1	ARID1A,HIST1H1C,EP300,SF3B1
GO:0035148	tube formation	0.005145617605553743	0.005145617605553743	+1	GATA3,NOTCH1,SOX9,FGFR2
GO:0030162	regulation of proteolysis	0.005183459172640318	0.005183459172640318	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,AKT1,HGF,LRRK2,TAF1,RPL5,SPOP
GO:0061647	histone H3-K9 modification	0.005276280589348421	0.005276280589348421	+1	ATRX,BRCA1,SMAD4
GO:0070102	interleukin-6-mediated signaling pathway	0.005276280589348421	0.005276280589348421	+1	CEBPA,SMAD4,PTPN11
GO:0071364	cellular response to epidermal growth factor stimulus	0.005276280589348421	0.005276280589348421	+1	EGFR,SOX9,PTPN11
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	0.005309186162788313	0.005309186162788313	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0070661	leukocyte proliferation	0.005360372727857952	0.005360372727857952	+1	CDKN2A,FLT3,PIK3CG,ATM,KIT,TGFBR2,MAPK8IP1
GO:0030030	cell projection organization	0.005360372727857952	0.005360372727857952	+1	PIK3CA,PTEN,APC,NAV3,PIK3R1,RB1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,LRRK2,KIT,EP300,FGFR2,USP9X,PPP2R1A,SIN3A,PTPN11
GO:0048640	negative regulation of developmental growth	0.005417520002858563	0.005417520002858563	+1	PTEN,CDKN1B,FGFR3,CDKN1A
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	0.005417520002858563	0.005417520002858563	+1	FLT3,ERBB4,KIT,FGFR3
GO:1905475	regulation of protein localization to membrane	0.005428631330841513	0.005428631330841513	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1,AR
GO:0072593	reactive oxygen species metabolic process	0.005480967303885677	0.005480967303885677	+1	TP53,AKT1,TLR4,BRCA1,LRRK2,TGFBR2,CDKN1A
GO:0010001	glial cell differentiation	0.0054929043655099425	0.0054929043655099425	+1	PTEN,NF1,NOTCH1,SOX9,MIR142
GO:1905477	positive regulation of protein localization to membrane	0.0054929043655099425	0.0054929043655099425	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1
GO:0022414	reproductive process	0.005584594523563722	0.005584594523563722	+1	GATA3,TBX3,SOX9,ATM,WT1,KIT,PDGFRA,FGFR2,USP9X,SMC1A,PTPN11,ACVR1B,SMC3,RAD21
GO:0031669	cellular response to nutrient levels	0.005584594523563722	0.005584594523563722	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:0032990	cell part morphogenesis	0.005610649435598553	0.005610649435598553	+1	PIK3CA,PTEN,PIK3R1,CTNNB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:0051960	regulation of nervous system development	0.005663449715123991	0.005663449715123991	+1	PTEN,NF1,NOTCH1,CTNNB1,ARHGAP35,EPHA3,AKT1,SOX9,LRRK2,EP300,SIN3A,MIR142
GO:0000280	nuclear division	0.005731288242678075	0.005731288242678075	+1	APC,RB1,STAG2,ATM,ATRX,CHEK2,SMC1A,SMC3,RAD21
GO:0009948	anterior/posterior axis specification	0.005731288242678075	0.005731288242678075	+1	TBX3,WT1,FOXA2
GO:0061136	regulation of proteasomal protein catabolic process	0.005731288242678075	0.005731288242678075	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0090184	positive regulation of kidney development	0.005731288242678075	0.005731288242678075	+1	GATA3,SOX9,WT1
GO:0003203	endocardial cushion morphogenesis	0.005731288242678075	0.005731288242678075	+1	NOTCH1,SOX9,TGFBR2
GO:0043525	positive regulation of neuron apoptotic process	0.005731288242678075	0.005731288242678075	+1	NF1,FBXW7,CTNNB1
GO:0044319	wound healing, spreading of cells	0.005731288242678075	0.005731288242678075	+1	PTEN,ARHGAP35,MTOR
GO:0090505	epiboly involved in wound healing	0.005731288242678075	0.005731288242678075	+1	PTEN,ARHGAP35,MTOR
GO:0051251	positive regulation of lymphocyte activation	0.005799197035356336	0.005799197035356336	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
GO:0000003	reproduction	0.005808204206449331	0.005808204206449331	+1	GATA3,TBX3,SOX9,ATM,WT1,KIT,PDGFRA,FGFR2,USP9X,SMC1A,PTPN11,ACVR1B,SMC3,RAD21
GO:0072009	nephron epithelium development	0.005981211306738115	0.005981211306738115	+1	GATA3,CTNNB1,SOX9,WT1
GO:0008637	apoptotic mitochondrial changes	0.006118221369354681	0.006118221369354681	+1	TP53,CDKN2A,AKT1,HGF,ERBB4
GO:0034622	cellular protein-containing complex assembly	0.006118828911939781	0.006118828911939781	+1	TP53,NAV3,RB1,NPM1,SOX9,ATM,TLR4,ATRX,SMAD4,SF3B1,TAF1,ATR,HIST1H2BD,RPL5,SMAD2,ERCC2
GO:0007423	sensory organ development	0.0061285572284213085	0.0061285572284213085	+1	NF1,GATA3,SOX9,WT1,PDGFRA,FGFR2,PTPN11
GO:0010719	negative regulation of epithelial to mesenchymal transition	0.006264783612251723	0.006264783612251723	+1	PTEN,FOXA1,FOXA2
GO:0090504	epiboly	0.006264783612251723	0.006264783612251723	+1	PTEN,ARHGAP35,MTOR
GO:2001024	negative regulation of response to drug	0.006264783612251723	0.006264783612251723	+1	NFE2L2,HGF,LRRK2
GO:1904837	beta-catenin-TCF complex assembly	0.006264783612251723	0.006264783612251723	+1	CTNNB1,EP300,AXIN2
GO:0045621	positive regulation of lymphocyte differentiation	0.006272660594939077	0.006272660594939077	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0090398	cellular senescence	0.006272660594939077	0.006272660594939077	+1	TP53,CDKN2A,TBX3,CDKN1A
GO:0031099	regeneration	0.006272660594939077	0.006272660594939077	+1	EPPK1,CDKN1B,ERBB4,CDKN1A
GO:0048711	positive regulation of astrocyte differentiation	0.0063814722251493644	0.0063814722251493644	+1	NOTCH1,MIR142
GO:0010259	multicellular organism aging	0.0063814722251493644	0.0063814722251493644	+1	TP53,LRRK2
GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	0.0063814722251493644	0.0063814722251493644	+1	RUNX1,CBFB
GO:2000615	regulation of histone H3-K9 acetylation	0.0063814722251493644	0.0063814722251493644	+1	BRCA1,SMAD4
GO:0032071	regulation of endodeoxyribonuclease activity	0.0063814722251493644	0.0063814722251493644	+1	NPM1,AKT1
GO:0007179	transforming growth factor beta receptor signaling pathway	0.0063814722251493644	0.0063814722251493644	+1	STK11,EP300,SMAD4,USP9X,TGFBR2,SMAD2
GO:0034698	response to gonadotropin	0.0063814722251493644	0.0063814722251493644	+1	NOTCH1,WT1
GO:0062042	regulation of cardiac epithelial to mesenchymal transition	0.0063814722251493644	0.0063814722251493644	+1	NOTCH1,TGFBR2
GO:0090400	stress-induced premature senescence	0.0063814722251493644	0.0063814722251493644	+1	TP53,CDKN1A
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	0.0063814722251493644	0.0063814722251493644	+1	PIK3CA,PIK3CG
GO:0090394	negative regulation of excitatory postsynaptic potential	0.0063814722251493644	0.0063814722251493644	+1	PTEN,LRRK2
GO:0072497	mesenchymal stem cell differentiation	0.0063814722251493644	0.0063814722251493644	+1	SOX9,PDGFRA
GO:0072239	metanephric glomerulus vasculature development	0.0063814722251493644	0.0063814722251493644	+1	WT1,PDGFRA
GO:0043970	histone H3-K9 acetylation	0.0063814722251493644	0.0063814722251493644	+1	BRCA1,SMAD4
GO:0071493	cellular response to UV-B	0.0063814722251493644	0.0063814722251493644	+1	STK11,CDKN1A
GO:0033599	regulation of mammary gland epithelial cell proliferation	0.0063814722251493644	0.0063814722251493644	+1	GATA3,BRCA2
GO:0006975	DNA damage induced protein phosphorylation	0.0063814722251493644	0.0063814722251493644	+1	ATM,CHEK2
GO:0060644	mammary gland epithelial cell differentiation	0.0063814722251493644	0.0063814722251493644	+1	AKT1,ERBB4
GO:0016573	histone acetylation	0.006442100193580826	0.006442100193580826	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0008286	insulin receptor signaling pathway	0.006442100193580826	0.006442100193580826	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0061564	axon development	0.006477531832451868	0.006477531832451868	+1	PIK3CA,PTEN,PIK3R1,ARHGAP35,EPHA3,FGFR2,USP9X,SIN3A,PTPN11
GO:0097191	extrinsic apoptotic signaling pathway	0.006647026135616155	0.006647026135616155	+1	PTEN,AKT1,AR,BRCA1,FGFR3,ACVR1B
GO:0051236	establishment of RNA localization	0.006647026135616155	0.006647026135616155	+1	NPM1,ATM,U2AF1,SETD2,TGFBR2,ATR
GO:0048660	regulation of smooth muscle cell proliferation	0.006649526787944383	0.006649526787944383	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:0070849	response to epidermal growth factor	0.006649526787944383	0.006649526787944383	+1	EGFR,SOX9,PTPN11
GO:0055023	positive regulation of cardiac muscle tissue growth	0.006649526787944383	0.006649526787944383	+1	NOTCH1,ERBB4,FGFR2
GO:0031572	G2 DNA damage checkpoint	0.006649526787944383	0.006649526787944383	+1	ATM,BRCA1,CDKN1A
GO:0008585	female gonad development	0.006649526787944383	0.006649526787944383	+1	WT1,KIT,PDGFRA
GO:0060675	ureteric bud morphogenesis	0.006649526787944383	0.006649526787944383	+1	GATA3,SOX9,WT1
GO:0071542	dopaminergic neuron differentiation	0.006649526787944383	0.006649526787944383	+1	CTNNB1,FOXA1,FOXA2
GO:0006739	NADP metabolic process	0.006649526787944383	0.006649526787944383	+1	TP53,IDH1,IDH2
GO:0018210	peptidyl-threonine modification	0.006649526787944383	0.006649526787944383	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	0.006649526787944383	0.006649526787944383	+1	CRIPAK,BRCA1,NCOR1
GO:0036474	cell death in response to hydrogen peroxide	0.006649526787944383	0.006649526787944383	+1	NFE2L2,HGF,LRRK2
GO:0002683	negative regulation of immune system process	0.006767360572896106	0.006767360572896106	+1	CDKN2A,NOTCH1,FBXW7,RUNX1,AKT1,SOX9,ATM,TLR4,CBFB
GO:0031334	positive regulation of protein-containing complex assembly	0.007022613805306231	0.007022613805306231	+1	TP53,NAV3,AJUBA,ATM,TLR4,ATR,ERCC2
GO:0006935	chemotaxis	0.007113911062493618	0.007113911062493618	+1	PIK3CA,PIK3R1,NOTCH1,ARHGAP35,EPHA3,PIK3CG,HGF,KIT,PDGFRA,PTPN11,EGR3
GO:0018393	internal peptidyl-lysine acetylation	0.007113911062493618	0.007113911062493618	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0048659	smooth muscle cell proliferation	0.007113911062493618	0.007113911062493618	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
GO:0033047	regulation of mitotic sister chromatid segregation	0.007113911062493618	0.007113911062493618	+1	APC,RB1,ATM,ATRX
GO:1903747	regulation of establishment of protein localization to mitochondrion	0.007113911062493618	0.007113911062493618	+1	TP53,FBXW7,BAP1,LRRK2
GO:0042330	taxis	0.007113911062493618	0.007113911062493618	+1	PIK3CA,PIK3R1,NOTCH1,ARHGAP35,EPHA3,PIK3CG,HGF,KIT,PDGFRA,PTPN11,EGR3
GO:0007017	microtubule-based process	0.00714471697460974	0.00714471697460974	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,CHEK2,SETD2,BRCA2,SMC1A,SMC3,NCOR1
GO:0001816	cytokine production	0.00714471697460974	0.00714471697460974	+1	NAV3,GATA3,CTNNB1,RUNX1,PIK3CG,TLR4,BRCA1,KIT,SETD2,EP300,SMAD4,PTPN11,MIR142
GO:0031062	positive regulation of histone methylation	0.007185162893120945	0.007185162893120945	+1	CTNNB1,BRCA1,SMAD4
GO:0010677	negative regulation of cellular carbohydrate metabolic process	0.007185162893120945	0.007185162893120945	+1	EP300,FOXA2,NCOR1
GO:2000142	regulation of DNA-templated transcription, initiation	0.007185162893120945	0.007185162893120945	+1	TP53,CTNNB1,TAF1
GO:0045661	regulation of myoblast differentiation	0.007185162893120945	0.007185162893120945	+1	NOTCH1,TBX3,SOX9
GO:1902116	negative regulation of organelle assembly	0.007185162893120945	0.007185162893120945	+1	BRCA1,LRRK2,SMAD4
GO:0046545	development of primary female sexual characteristics	0.007185162893120945	0.007185162893120945	+1	WT1,KIT,PDGFRA
GO:0090090	negative regulation of canonical Wnt signaling pathway	0.007304141579942403	0.007304141579942403	+1	APC,STK11,SOX9,SOX17,MAPK8IP1,AXIN2
GO:0031397	negative regulation of protein ubiquitination	0.00742899190224513	0.00742899190224513	+1	CDKN2A,AKT1,TAF1,RPL5
GO:0061351	neural precursor cell proliferation	0.00742899190224513	0.00742899190224513	+1	NF1,CTNNB1,LRRK2,FGFR2
GO:0033135	regulation of peptidyl-serine phosphorylation	0.007569676893350907	0.007569676893350907	+1	PTEN,EGFR,AKT1,BRAF,NSD1
GO:0090287	regulation of cellular response to growth factor stimulus	0.007613722625560039	0.007613722625560039	+1	GATA3,NOTCH1,STK11,EP300,SMAD4,TGFBR2,SMAD2
GO:0035520	monoubiquitinated protein deubiquitination	0.007779636791960299	0.007779636791960299	+1	BAP1,ASXL1
GO:0048557	embryonic digestive tract morphogenesis	0.007779636791960299	0.007779636791960299	+1	PDGFRA,FGFR2
GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	0.007779636791960299	0.007779636791960299	+1	TP53,EGFR
GO:0051336	regulation of hydrolase activity	0.007779636791960299	0.007779636791960299	+1	TP53,EGFR,NF1,CDKN2A,NPM1,EPHA3,AKT1,HGF,MTOR,LRRK2,KIT,PDGFRA,FGFR2,FGFR3,EZH2
GO:1905939	regulation of gonad development	0.007779636791960299	0.007779636791960299	+1	SOX9,WT1
GO:0072171	mesonephric tubule morphogenesis	0.007779636791960299	0.007779636791960299	+1	GATA3,SOX9,WT1
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	0.007779636791960299	0.007779636791960299	+1	FOXA1,FOXA2
GO:0055010	ventricular cardiac muscle tissue morphogenesis	0.007779636791960299	0.007779636791960299	+1	NOTCH1,FGFR2,SMAD4
GO:0072079	nephron tubule formation	0.007779636791960299	0.007779636791960299	+1	GATA3,SOX9
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	0.007779636791960299	0.007779636791960299	+1	TP53,NOTCH1,NFE2L2
GO:0007596	blood coagulation	0.007779636791960299	0.007779636791960299	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,TLR4,PDGFRA,FOXA2,PTPN11
GO:0043374	CD8-positive, alpha-beta T cell differentiation	0.007779636791960299	0.007779636791960299	+1	RUNX1,CBFB
GO:0002328	pro-B cell differentiation	0.007779636791960299	0.007779636791960299	+1	NOTCH1,FLT3
GO:0032479	regulation of type I interferon production	0.008036325096111567	0.008036325096111567	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:0045619	regulation of lymphocyte differentiation	0.008036325096111567	0.008036325096111567	+1	CDKN2A,GATA3,RUNX1,TGFBR2,CBFB
GO:0044248	cellular catabolic process	0.008104860436640817	0.008104860436640817	+1	TP53,PIK3CA,PTEN,CDKN2A,FBXW7,CTNNB1,KEAP1,NFE2L2,NPM1,RPL22,STK11,CEBPA,AKT1,ATM,HGF,MTOR,TET2,LRRK2,CHEK2,EP300,USP9X,TAF1,PPP2R1A,TBL1XR1,RPL5,SPOP,AXIN2
GO:0007043	cell-cell junction assembly	0.008307400228430729	0.008307400228430729	+1	APC,CTNNB1,CDH1,RUNX1,CBFB
GO:0006475	internal protein amino acid acetylation	0.008307400228430729	0.008307400228430729	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0032606	type I interferon production	0.008307400228430729	0.008307400228430729	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
GO:0035850	epithelial cell differentiation involved in kidney development	0.008310675966382295	0.008310675966382295	+1	GATA3,CTNNB1,WT1
GO:0045912	negative regulation of carbohydrate metabolic process	0.008310675966382295	0.008310675966382295	+1	EP300,FOXA2,NCOR1
GO:0045685	regulation of glial cell differentiation	0.008310675966382295	0.008310675966382295	+1	NF1,NOTCH1,MIR142
GO:0046638	positive regulation of alpha-beta T cell differentiation	0.008310675966382295	0.008310675966382295	+1	RUNX1,TGFBR2,CBFB
GO:0018023	peptidyl-lysine trimethylation	0.008310675966382295	0.008310675966382295	+1	TET2,ATRX,SETD2
GO:1901031	regulation of response to reactive oxygen species	0.008310675966382295	0.008310675966382295	+1	NFE2L2,HGF,LRRK2
GO:0007599	hemostasis	0.008310675966382295	0.008310675966382295	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,TLR4,PDGFRA,FOXA2,PTPN11
GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	0.008310675966382295	0.008310675966382295	+1	TP53,SOX9,WT1
GO:0032924	activin receptor signaling pathway	0.008310675966382295	0.008310675966382295	+1	ACVR1B,ACVR2A,SMAD2
GO:0000086	G2/M transition of mitotic cell cycle	0.008360683208405694	0.008360683208405694	+1	CDKN2A,AJUBA,ATM,CHEK2,CCND1,CDKN1A,PPP2R1A
GO:0050817	coagulation	0.008466761917767176	0.008466761917767176	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,TLR4,PDGFRA,FOXA2,PTPN11
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	0.008513137606334707	0.008513137606334707	+1	PTEN,CDKN2A,FBXW7,BRCA1,LRRK2
GO:0018394	peptidyl-lysine acetylation	0.008513137606334707	0.008513137606334707	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0000904	cell morphogenesis involved in differentiation	0.008786368579308569	0.008786368579308569	+1	PIK3CA,PTEN,PIK3R1,RB1,ARHGAP35,EPHA3,LRRK2,FGFR2,USP9X,SIN3A,PTPN11
GO:1901992	positive regulation of mitotic cell cycle phase transition	0.008834446135864305	0.008834446135864305	+1	EGFR,RB1,AKT1,CCND1
GO:0021954	central nervous system neuron development	0.008923785369001121	0.008923785369001121	+1	PTEN,ARHGAP35,FGFR2
GO:0046329	negative regulation of JNK cascade	0.008923785369001121	0.008923785369001121	+1	MAPK8IP1,MECOM,NCOR1
GO:0032355	response to estradiol	0.008923785369001121	0.008923785369001121	+1	EGFR,CTNNB1,FOXA1
GO:0045581	negative regulation of T cell differentiation	0.008923785369001121	0.008923785369001121	+1	CDKN2A,RUNX1,CBFB
GO:0060021	roof of mouth development	0.008923785369001121	0.008923785369001121	+1	SMAD4,TGFBR2,SMAD2
GO:0003229	ventricular cardiac muscle tissue development	0.008923785369001121	0.008923785369001121	+1	NOTCH1,FGFR2,SMAD4
GO:0045746	negative regulation of Notch signaling pathway	0.008923785369001121	0.008923785369001121	+1	EGFR,FBXW7,AKT1
GO:0003197	endocardial cushion development	0.008923785369001121	0.008923785369001121	+1	NOTCH1,SOX9,TGFBR2
GO:0044344	cellular response to fibroblast growth factor stimulus	0.009048755582133632	0.009048755582133632	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:0006282	regulation of DNA repair	0.009048755582133632	0.009048755582133632	+1	EGFR,BRCA1,POLQ,SETD2,AXIN2
GO:2000146	negative regulation of cell motility	0.009056273840605684	0.009056273840605684	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1
GO:0046634	regulation of alpha-beta T cell activation	0.009175006391792763	0.009175006391792763	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:1904659	glucose transmembrane transport	0.009175006391792763	0.009175006391792763	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0007162	negative regulation of cell adhesion	0.009241591695410577	0.009241591695410577	+1	PTEN,CDKN2A,NOTCH1,CDH1,RUNX1,AKT1,CBFB
GO:0072182	regulation of nephron tubule epithelial cell differentiation	0.009266197391603597	0.009266197391603597	+1	GATA3,CTNNB1
GO:1901722	regulation of cell proliferation involved in kidney development	0.009266197391603597	0.009266197391603597	+1	GATA3,WT1
GO:0033598	mammary gland epithelial cell proliferation	0.009266197391603597	0.009266197391603597	+1	GATA3,BRCA2
GO:1904667	negative regulation of ubiquitin protein ligase activity	0.009266197391603597	0.009266197391603597	+1	CDKN2A,RPL5
GO:0032070	regulation of deoxyribonuclease activity	0.009266197391603597	0.009266197391603597	+1	NPM1,AKT1
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	0.009266197391603597	0.009266197391603597	+1	CRIPAK,BRCA1
GO:0035272	exocrine system development	0.009266197391603597	0.009266197391603597	+1	HGF,FGFR2
GO:0030850	prostate gland development	0.009266197391603597	0.009266197391603597	+1	SOX9,FGFR2
GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	0.009266197391603597	0.009266197391603597	+1	AKT1,TLR4
GO:0060443	mammary gland morphogenesis	0.009266197391603597	0.009266197391603597	+1	ELF3,FGFR2
GO:0007183	SMAD protein complex assembly	0.009266197391603597	0.009266197391603597	+1	SMAD4,SMAD2
GO:0060911	cardiac cell fate commitment	0.009266197391603597	0.009266197391603597	+1	WT1,SOX17
GO:0060043	regulation of cardiac muscle cell proliferation	0.009498657171733937	0.009498657171733937	+1	NOTCH1,ERBB4,FGFR2
GO:0046854	phosphatidylinositol phosphorylation	0.009498657171733937	0.009498657171733937	+1	PIK3CA,PIK3R1,PIK3CG
GO:1904706	negative regulation of vascular smooth muscle cell proliferation	0.009498657171733937	0.009498657171733937	+1	PTEN,CDKN1B,CDKN1A
GO:0071774	response to fibroblast growth factor	0.00952830390656416	0.00952830390656416	+1	GATA3,FGFR2,FGFR3,PTPN11,EGR3
GO:1902850	microtubule cytoskeleton organization involved in mitosis	0.00952830390656416	0.00952830390656416	+1	STAG2,CHEK2,SETD2,SMC1A,SMC3
GO:0045862	positive regulation of proteolysis	0.009623189465113424	0.009623189465113424	+1	PTEN,CDKN2A,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
GO:0043068	positive regulation of programmed cell death	0.009706366710792183	0.009706366710792183	+1	TP53,PTEN,APC,NF1,CDKN2A,NOTCH1,FBXW7,CTNNB1,ATM,LRRK2,FOXA1
GO:0042692	muscle cell differentiation	0.009725472572124857	0.009725472572124857	+1	NOTCH1,CTNNB1,WT1,KIT,PDGFRA,FGFR2,SMAD4
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.009913152135011644	0.009913152135011644	+1	VHL,NOTCH1,NFE2L2,EP300
GO:0072078	nephron tubule morphogenesis	0.010143113619696909	0.010143113619696909	+1	GATA3,SOX9,WT1
GO:0060236	regulation of mitotic spindle organization	0.010143113619696909	0.010143113619696909	+1	STAG2,SMC1A,SMC3
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	0.010143113619696909	0.010143113619696909	+1	FBXW7,NFE2L2,AKT1
GO:0051494	negative regulation of cytoskeleton organization	0.010143113619696909	0.010143113619696909	+1	APC,NAV3,NPM1,BRCA1,SMAD4
GO:0030509	BMP signaling pathway	0.010143113619696909	0.010143113619696909	+1	NOTCH1,SMAD4,USP9X,ACVR2A,SMAD2
GO:0010823	negative regulation of mitochondrion organization	0.010143113619696909	0.010143113619696909	+1	AKT1,HGF,LRRK2
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	0.010143113619696909	0.010143113619696909	+1	EGFR,AKT1,CCND1
GO:2001038	regulation of cellular response to drug	0.010143113619696909	0.010143113619696909	+1	NFE2L2,HGF,LRRK2
GO:0031648	protein destabilization	0.010143113619696909	0.010143113619696909	+1	CDKN2A,EP300,SOX17
GO:0046822	regulation of nucleocytoplasmic transport	0.010294486028250461	0.010294486028250461	+1	TP53,PIK3R1,CDH1,SETD2
GO:0062014	negative regulation of small molecule metabolic process	0.010294486028250461	0.010294486028250461	+1	AKT1,BRCA1,EP300,NCOR1
GO:1901214	regulation of neuron death	0.010341034749935585	0.010341034749935585	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
GO:0090316	positive regulation of intracellular protein transport	0.010408544163936374	0.010408544163936374	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1
GO:0002761	regulation of myeloid leukocyte differentiation	0.01071220239312755	0.01071220239312755	+1	FBXW7,RUNX1,MTOR,TLR4
GO:0006302	double-strand break repair	0.01071220239312755	0.01071220239312755	+1	ATM,BRCA1,POLQ,CHEK2,SETD2,BRCA2,RAD21
GO:0060218	hematopoietic stem cell differentiation	0.01071220239312755	0.01071220239312755	+1	TP53,GATA3,RUNX1,CBFB
GO:0034330	cell junction organization	0.01071220239312755	0.01071220239312755	+1	PTEN,APC,CTNNB1,CDH1,RUNX1,EPHA3,CBFB
GO:0009408	response to heat	0.01071220239312755	0.01071220239312755	+1	AKT1,ATM,MTOR,EP300,ATR
GO:0045833	negative regulation of lipid metabolic process	0.01071220239312755	0.01071220239312755	+1	FBXW7,AKT1,BRCA1,NCOR1
GO:2000177	regulation of neural precursor cell proliferation	0.01081761050834791	0.01081761050834791	+1	NF1,CTNNB1,LRRK2
GO:0061005	cell differentiation involved in kidney development	0.01081761050834791	0.01081761050834791	+1	GATA3,CTNNB1,WT1
GO:0045620	negative regulation of lymphocyte differentiation	0.01081761050834791	0.01081761050834791	+1	CDKN2A,RUNX1,CBFB
GO:0048708	astrocyte differentiation	0.01081761050834791	0.01081761050834791	+1	NF1,NOTCH1,MIR142
GO:0050878	regulation of body fluid levels	0.010838743154297016	0.010838743154297016	+1	PIK3CA,PIK3R1,GATA3,PIK3CG,ERBB4,TLR4,PDGFRA,FOXA2,PTPN11
GO:0045184	establishment of protein localization	0.010842307505651001	0.010842307505651001	+1	TP53,EGFR,PIK3R1,GATA3,FBXW7,CDH1,BAP1,NPM1,IDH1,RPL22,AKT1,BRAF,ATM,TLR4,U2AF1,LRRK2,SETD2,FOXA2,USP9X,BRCA2,ATR,RPL5,MIR142
GO:0021772	olfactory bulb development	0.010857965537519488	0.010857965537519488	+1	ERBB4,LRRK2
GO:0010452	histone H3-K36 methylation	0.010857965537519488	0.010857965537519488	+1	SETD2,NSD1
GO:0030325	adrenal gland development	0.010857965537519488	0.010857965537519488	+1	NF1,WT1
GO:0003401	axis elongation	0.010857965537519488	0.010857965537519488	+1	SOX9,FGFR2
GO:0010826	negative regulation of centrosome duplication	0.010857965537519488	0.010857965537519488	+1	NPM1,BRCA1
GO:0060039	pericardium development	0.010857965537519488	0.010857965537519488	+1	NOTCH1,WT1
GO:1902969	mitotic DNA replication	0.010857965537519488	0.010857965537519488	+1	CHEK2,BRCA2
GO:0003188	heart valve formation	0.010857965537519488	0.010857965537519488	+1	NOTCH1,SMAD4
GO:0090263	positive regulation of canonical Wnt signaling pathway	0.010931280148933815	0.010931280148933815	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
GO:0006368	transcription elongation from RNA polymerase II promoter	0.011043364069316873	0.011043364069316873	+1	PBRM1,SETD2,CDK12,ERCC2
GO:1900034	regulation of cellular response to heat	0.011043364069316873	0.011043364069316873	+1	ATM,MTOR,EP300,ATR
GO:0045652	regulation of megakaryocyte differentiation	0.011043364069316873	0.011043364069316873	+1	RUNX1,EP300,CBFB,SIN3A
GO:0030278	regulation of ossification	0.011261562153288713	0.011261562153288713	+1	NOTCH1,SOX9,HGF,FGFR2,ACVR2A
GO:0055025	positive regulation of cardiac muscle tissue development	0.011424393825794943	0.011424393825794943	+1	NOTCH1,ERBB4,FGFR2
GO:0072088	nephron epithelium morphogenesis	0.011424393825794943	0.011424393825794943	+1	GATA3,SOX9,WT1
GO:0060038	cardiac muscle cell proliferation	0.011424393825794943	0.011424393825794943	+1	NOTCH1,ERBB4,FGFR2
GO:0072028	nephron morphogenesis	0.011424393825794943	0.011424393825794943	+1	GATA3,SOX9,WT1
GO:0033048	negative regulation of mitotic sister chromatid segregation	0.011424393825794943	0.011424393825794943	+1	APC,ATM,ATRX
GO:0061614	pri-miRNA transcription by RNA polymerase II	0.011424393825794943	0.011424393825794943	+1	TP53,SOX9,WT1
GO:0071354	cellular response to interleukin-6	0.011424393825794943	0.011424393825794943	+1	CEBPA,SMAD4,PTPN11
GO:0035065	regulation of histone acetylation	0.011424393825794943	0.011424393825794943	+1	BRCA1,SMAD4,SIN3A
GO:0008645	hexose transmembrane transport	0.011458103154003751	0.011458103154003751	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:2001242	regulation of intrinsic apoptotic signaling pathway	0.011523700657460436	0.011523700657460436	+1	TP53,FBXW7,NFE2L2,AKT1,LRRK2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	0.011523700657460436	0.011523700657460436	+1	FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,TBL1XR1,SPOP
GO:0002764	immune response-regulating signaling pathway	0.011523700657460436	0.011523700657460436	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,MAP2K4,TLR4,KIT,EP300,CBFB
GO:0072655	establishment of protein localization to mitochondrion	0.011523700657460436	0.011523700657460436	+1	TP53,FBXW7,BAP1,AKT1,LRRK2
GO:0032102	negative regulation of response to external stimulus	0.011765458884787364	0.011765458884787364	+1	PTEN,GATA3,RB1,NOTCH1,EPPK1,CDKN1B,PDGFRA,CDKN1A
GO:0031331	positive regulation of cellular catabolic process	0.011765458884787364	0.011765458884787364	+1	PTEN,FBXW7,KEAP1,NFE2L2,STK11,CEBPA,LRRK2,TAF1
GO:0009991	response to extracellular stimulus	0.01183441424720426	0.01183441424720426	+1	TP53,ARHGAP35,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:1901888	regulation of cell junction assembly	0.011901847801317414	0.011901847801317414	+1	PTEN,RUNX1,EPHA3,CBFB
GO:0010721	negative regulation of cell development	0.011968027308512019	0.011968027308512019	+1	PTEN,NF1,NOTCH1,FBXW7,SOX9,SMAD4
GO:0090199	regulation of release of cytochrome c from mitochondria	0.012126584391235795	0.012126584391235795	+1	TP53,AKT1,HGF
GO:0061333	renal tubule morphogenesis	0.012126584391235795	0.012126584391235795	+1	GATA3,SOX9,WT1
GO:0090224	regulation of spindle organization	0.012126584391235795	0.012126584391235795	+1	STAG2,SMC1A,SMC3
GO:1903214	regulation of protein targeting to mitochondrion	0.012126584391235795	0.012126584391235795	+1	FBXW7,BAP1,LRRK2
GO:0010863	positive regulation of phospholipase C activity	0.012126584391235795	0.012126584391235795	+1	EGFR,KIT,PDGFRA
GO:0061448	connective tissue development	0.01216713867984906	0.01216713867984906	+1	RUNX1,SOX9,WT1,ARID5B,FGFR3
GO:0006629	lipid metabolic process	0.01231517732743058	0.01231517732743058	+1	PIK3CA,PTEN,PIK3R1,RB1,FBXW7,FLT3,AKT1,PIK3CG,MTOR,BRCA1,KIT,PDGFRA,FGFR3,B4GALT3,PPP2R1A,SIN3A,TBL1XR1,NCOR1
GO:0034219	carbohydrate transmembrane transport	0.01231517732743058	0.01231517732743058	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:1900180	regulation of protein localization to nucleus	0.01231517732743058	0.01231517732743058	+1	PIK3R1,CDH1,AKT1,SIN3A
GO:1901532	regulation of hematopoietic progenitor cell differentiation	0.01231517732743058	0.01231517732743058	+1	GATA3,NOTCH1,RUNX1,CBFB
GO:0015749	monosaccharide transmembrane transport	0.01231517732743058	0.01231517732743058	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0072160	nephron tubule epithelial cell differentiation	0.012414874870746844	0.012414874870746844	+1	GATA3,CTNNB1
GO:0034088	maintenance of mitotic sister chromatid cohesion	0.012414874870746844	0.012414874870746844	+1	RB1,ATRX
GO:0034086	maintenance of sister chromatid cohesion	0.012414874870746844	0.012414874870746844	+1	RB1,ATRX
GO:0021988	olfactory lobe development	0.012414874870746844	0.012414874870746844	+1	ERBB4,LRRK2
GO:0051147	regulation of muscle cell differentiation	0.012414874870746844	0.012414874870746844	+1	NOTCH1,CTNNB1,KIT,FGFR2,SMAD4
GO:0035988	chondrocyte proliferation	0.012414874870746844	0.012414874870746844	+1	SOX9,FGFR3
GO:0072350	tricarboxylic acid metabolic process	0.012414874870746844	0.012414874870746844	+1	IDH1,IDH2
GO:0070585	protein localization to mitochondrion	0.012414874870746844	0.012414874870746844	+1	TP53,FBXW7,BAP1,AKT1,LRRK2
GO:1903209	positive regulation of oxidative stress-induced cell death	0.012414874870746844	0.012414874870746844	+1	FBXW7,TLR4
GO:0035067	negative regulation of histone acetylation	0.012414874870746844	0.012414874870746844	+1	BRCA1,SIN3A
GO:0030889	negative regulation of B cell proliferation	0.012414874870746844	0.012414874870746844	+1	CDKN2A,ATM
GO:0007350	blastoderm segmentation	0.012414874870746844	0.012414874870746844	+1	TBX3,WT1
GO:0072224	metanephric glomerulus development	0.012414874870746844	0.012414874870746844	+1	WT1,PDGFRA
GO:0007351	tripartite regional subdivision	0.012414874870746844	0.012414874870746844	+1	TBX3,WT1
GO:0106030	neuron projection fasciculation	0.012414874870746844	0.012414874870746844	+1	ARHGAP35,EPHA3
GO:0007413	axonal fasciculation	0.012414874870746844	0.012414874870746844	+1	ARHGAP35,EPHA3
GO:0008595	anterior/posterior axis specification, embryo	0.012414874870746844	0.012414874870746844	+1	TBX3,WT1
GO:0030178	negative regulation of Wnt signaling pathway	0.012607225867857919	0.012607225867857919	+1	APC,STK11,SOX9,SOX17,MAPK8IP1,AXIN2
GO:1905269	positive regulation of chromatin organization	0.012659507411745327	0.012659507411745327	+1	CTNNB1,BRCA1,SMAD4,SIN3A
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	0.012678734423293187	0.012678734423293187	+1	CDKN2A,TAF1,RPL5
GO:0033046	negative regulation of sister chromatid segregation	0.012678734423293187	0.012678734423293187	+1	APC,ATM,ATRX
GO:0051223	regulation of protein transport	0.012678734423293187	0.012678734423293187	+1	TP53,PIK3R1,GATA3,FBXW7,CDH1,BAP1,TLR4,LRRK2,SETD2,FOXA2,MIR142
GO:0045747	positive regulation of Notch signaling pathway	0.012678734423293187	0.012678734423293187	+1	NOTCH1,ELF3,EP300
GO:0046324	regulation of glucose import	0.012678734423293187	0.012678734423293187	+1	PIK3R1,AKT1,PTPN11
GO:0045670	regulation of osteoclast differentiation	0.012678734423293187	0.012678734423293187	+1	FBXW7,MTOR,TLR4
GO:0014706	striated muscle tissue development	0.012842906287780537	0.012842906287780537	+1	NOTCH1,WT1,ERBB4,PDGFRA,FGFR2,SMAD4
GO:1905330	regulation of morphogenesis of an epithelium	0.013030049062386159	0.013030049062386159	+1	PTEN,GATA3,SOX9,HGF,MTOR
GO:0000018	regulation of DNA recombination	0.013106752249078257	0.013106752249078257	+1	POLQ,HIST1H1C,SETD2,ERCC2
GO:0045667	regulation of osteoblast differentiation	0.013106752249078257	0.013106752249078257	+1	NOTCH1,HGF,FGFR2,ACVR2A
GO:0046651	lymphocyte proliferation	0.013124520503460954	0.013124520503460954	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:0045931	positive regulation of mitotic cell cycle	0.01339874925969384	0.01339874925969384	+1	EGFR,RB1,AKT1,FOXA1,CCND1
GO:0055021	regulation of cardiac muscle tissue growth	0.013445727401735554	0.013445727401735554	+1	NOTCH1,ERBB4,FGFR2
GO:1900274	regulation of phospholipase C activity	0.013445727401735554	0.013445727401735554	+1	EGFR,KIT,PDGFRA
GO:0038202	TORC1 signaling	0.013445727401735554	0.013445727401735554	+1	STK11,ATM,MTOR
GO:0072091	regulation of stem cell proliferation	0.013445727401735554	0.013445727401735554	+1	NF1,CTNNB1,LRRK2
GO:0051985	negative regulation of chromosome segregation	0.013445727401735554	0.013445727401735554	+1	APC,ATM,ATRX
GO:0006984	ER-nucleus signaling pathway	0.013445727401735554	0.013445727401735554	+1	TP53,FBXW7,NFE2L2
GO:0051271	negative regulation of cellular component movement	0.013531889202277152	0.013531889202277152	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1
GO:0045995	regulation of embryonic development	0.013562758446583577	0.013562758446583577	+1	GATA3,CTNNB1,FOXA2,SOX17
GO:0006403	RNA localization	0.013994551723311757	0.013994551723311757	+1	NPM1,ATM,U2AF1,SETD2,TGFBR2,ATR
GO:0032943	mononuclear cell proliferation	0.013994551723311757	0.013994551723311757	+1	CDKN2A,FLT3,PIK3CG,ATM,TGFBR2,MAPK8IP1
GO:0070997	neuron death	0.013994551723311757	0.013994551723311757	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
GO:0006396	RNA processing	0.014099929495106567	0.014099929495106567	+1	TP53,EGFR,PIK3R1,WT1,PRX,U2AF1,SF3B1,PPP2R1A,CDK12,NCOR1,RPL5,SMAD2,ERCC2,PCBP1
GO:0010224	response to UV-B	0.014143365346040796	0.014143365346040796	+1	STK11,CDKN1A
GO:0002320	lymphoid progenitor cell differentiation	0.014143365346040796	0.014143365346040796	+1	NOTCH1,FLT3
GO:0007530	sex determination	0.014143365346040796	0.014143365346040796	+1	SOX9,WT1
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	0.014143365346040796	0.014143365346040796	+1	NOTCH1,TGFBR2
GO:0060231	mesenchymal to epithelial transition	0.014143365346040796	0.014143365346040796	+1	GATA3,WT1
GO:0072273	metanephric nephron morphogenesis	0.014143365346040796	0.014143365346040796	+1	SOX9,WT1
GO:0046606	negative regulation of centrosome cycle	0.014143365346040796	0.014143365346040796	+1	NPM1,BRCA1
GO:2000696	regulation of epithelial cell differentiation involved in kidney development	0.014143365346040796	0.014143365346040796	+1	GATA3,CTNNB1
GO:0033262	regulation of nuclear cell cycle DNA replication	0.014143365346040796	0.014143365346040796	+1	ATRX,CHEK2
GO:1905331	negative regulation of morphogenesis of an epithelium	0.014143365346040796	0.014143365346040796	+1	PTEN,GATA3
GO:0044331	cell-cell adhesion mediated by cadherin	0.014143365346040796	0.014143365346040796	+1	CDH1,FOXA1,FOXA2
GO:2000756	regulation of peptidyl-lysine acetylation	0.014143365346040796	0.014143365346040796	+1	BRCA1,SMAD4,SIN3A
GO:2000757	negative regulation of peptidyl-lysine acetylation	0.014143365346040796	0.014143365346040796	+1	BRCA1,SIN3A
GO:0035162	embryonic hemopoiesis	0.014143365346040796	0.014143365346040796	+1	KIT,TGFBR2
GO:0045444	fat cell differentiation	0.014370388593326278	0.014370388593326278	+1	GATA3,CEBPA,AKT1,EP300,ASXL1
GO:0071300	cellular response to retinoic acid	0.015070720461631142	0.015070720461631142	+1	EPHA3,SOX9,ATM
GO:0016202	regulation of striated muscle tissue development	0.015091694192628546	0.015091694192628546	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:0040013	negative regulation of locomotion	0.015567268380744851	0.015567268380744851	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1,EPPK1
GO:1901861	regulation of muscle tissue development	0.015685416539059038	0.015685416539059038	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:0010038	response to metal ion	0.015888409899981203	0.015888409899981203	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
GO:0060079	excitatory postsynaptic potential	0.015994373587124452	0.015994373587124452	+1	PTEN,AKT1,LRRK2
GO:0106106	cold-induced thermogenesis	0.01608252704559283	0.01608252704559283	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0120161	regulation of cold-induced thermogenesis	0.01608252704559283	0.01608252704559283	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0072425	signal transduction involved in G2 DNA damage checkpoint	0.01615535777207818	0.01615535777207818	+1	ATM,BRCA1
GO:0072207	metanephric epithelium development	0.01615535777207818	0.01615535777207818	+1	SOX9,WT1
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	0.01615535777207818	0.01615535777207818	+1	TP53,BRCA1
GO:0045446	endothelial cell differentiation	0.01615535777207818	0.01615535777207818	+1	NOTCH1,SMAD4,SOX17,VEZF1
GO:0035313	wound healing, spreading of epidermal cells	0.01615535777207818	0.01615535777207818	+1	PTEN,MTOR
GO:0038092	nodal signaling pathway	0.01615535777207818	0.01615535777207818	+1	ACVR1B,SMAD2
GO:0048385	regulation of retinoic acid receptor signaling pathway	0.01615535777207818	0.01615535777207818	+1	ASXL1,EZH2
GO:0090185	negative regulation of kidney development	0.01615535777207818	0.01615535777207818	+1	GATA3,WT1
GO:0006103	2-oxoglutarate metabolic process	0.01615535777207818	0.01615535777207818	+1	IDH1,IDH2
GO:0045686	negative regulation of glial cell differentiation	0.01615535777207818	0.01615535777207818	+1	NF1,NOTCH1
GO:0090087	regulation of peptide transport	0.01616346179780285	0.01616346179780285	+1	TP53,PIK3R1,GATA3,FBXW7,CDH1,BAP1,TLR4,LRRK2,SETD2,FOXA2,MIR142
GO:0042063	gliogenesis	0.01638741234569907	0.01638741234569907	+1	PTEN,NF1,NOTCH1,SOX9,MIR142
GO:0050866	negative regulation of cell activation	0.01638741234569907	0.01638741234569907	+1	CDKN2A,RUNX1,ATM,PDGFRA,CBFB
GO:0046834	lipid phosphorylation	0.01669565803694254	0.01669565803694254	+1	PIK3CA,PIK3R1,PIK3CG
GO:0055008	cardiac muscle tissue morphogenesis	0.01669565803694254	0.01669565803694254	+1	NOTCH1,FGFR2,SMAD4
GO:0035019	somatic stem cell population maintenance	0.01669565803694254	0.01669565803694254	+1	SOX9,SMAD4,SMAD2
GO:0035107	appendage morphogenesis	0.01669565803694254	0.01669565803694254	+1	CTNNB1,TBX3,FGFR2
GO:0035108	limb morphogenesis	0.01669565803694254	0.01669565803694254	+1	CTNNB1,TBX3,FGFR2
GO:0021537	telencephalon development	0.01669565803694254	0.01669565803694254	+1	PTEN,NF1,ERBB4,LRRK2
GO:0032873	negative regulation of stress-activated MAPK cascade	0.01669565803694254	0.01669565803694254	+1	MAPK8IP1,MECOM,NCOR1
GO:0070303	negative regulation of stress-activated protein kinase signaling cascade	0.01669565803694254	0.01669565803694254	+1	MAPK8IP1,MECOM,NCOR1
GO:0071236	cellular response to antibiotic	0.01669565803694254	0.01669565803694254	+1	TP53,NFE2L2,HGF,LRRK2
GO:0022408	negative regulation of cell-cell adhesion	0.016735091202238168	0.016735091202238168	+1	CDKN2A,CDH1,RUNX1,AKT1,CBFB
GO:0000070	mitotic sister chromatid segregation	0.01720770904936842	0.01720770904936842	+1	APC,RB1,ATM,ATRX,SMC1A
GO:2000278	regulation of DNA biosynthetic process	0.017213086510782138	0.017213086510782138	+1	TP53,ATM,HGF,ATR
GO:0051345	positive regulation of hydrolase activity	0.017213086510782138	0.017213086510782138	+1	EGFR,NF1,CDKN2A,AKT1,MTOR,KIT,PDGFRA,FGFR2,FGFR3,EZH2
GO:0008643	carbohydrate transport	0.017213086510782138	0.017213086510782138	+1	PIK3R1,AKT1,BRAF,PTPN11
GO:0014855	striated muscle cell proliferation	0.01762551153231658	0.01762551153231658	+1	NOTCH1,ERBB4,FGFR2
GO:0046637	regulation of alpha-beta T cell differentiation	0.01762551153231658	0.01762551153231658	+1	RUNX1,TGFBR2,CBFB
GO:0051966	regulation of synaptic transmission, glutamatergic	0.01762551153231658	0.01762551153231658	+1	TSHZ3,LRRK2,MIR142
GO:0007517	muscle organ development	0.017767267356933927	0.017767267356933927	+1	NOTCH1,WT1,ERBB4,FGFR2,SMAD4,EGR3
GO:0048634	regulation of muscle organ development	0.017813214941366493	0.017813214941366493	+1	NOTCH1,ERBB4,FGFR2,SMAD4
GO:1901653	cellular response to peptide	0.017945277249685695	0.017945277249685695	+1	TP53,PIK3CA,APC,PIK3R1,AKT1,TLR4,PTPN11
GO:0016071	mRNA metabolic process	0.018014954827235863	0.018014954827235863	+1	TP53,NPM1,RPL22,AKT1,ATM,U2AF1,SOX17,SF3B1,PPP2R1A,RPL5,AXIN2,ERCC2,PCBP1
GO:0035635	entry of bacterium into host cell	0.018061566660244867	0.018061566660244867	+1	CTNNB1,CDH1
GO:1900409	positive regulation of cellular response to oxidative stress	0.018061566660244867	0.018061566660244867	+1	FBXW7,TLR4
GO:0045992	negative regulation of embryonic development	0.018061566660244867	0.018061566660244867	+1	GATA3,CTNNB1
GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	0.018061566660244867	0.018061566660244867	+1	RUNX1,CBFB
GO:0007252	I-kappaB phosphorylation	0.018061566660244867	0.018061566660244867	+1	AKT1,TLR4
GO:0090201	negative regulation of release of cytochrome c from mitochondria	0.018061566660244867	0.018061566660244867	+1	AKT1,HGF
GO:0031645	negative regulation of nervous system process	0.018061566660244867	0.018061566660244867	+1	PTEN,LRRK2
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	0.018061566660244867	0.018061566660244867	+1	ATM,ATR
GO:0042772	DNA damage response, signal transduction resulting in transcription	0.018061566660244867	0.018061566660244867	+1	TP53,BRCA1
GO:0010165	response to X-ray	0.018061566660244867	0.018061566660244867	+1	GATA3,ATM
GO:0046635	positive regulation of alpha-beta T cell activation	0.01839599038682576	0.01839599038682576	+1	RUNX1,TGFBR2,CBFB
GO:0032386	regulation of intracellular transport	0.01839599038682576	0.01839599038682576	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,LRRK2,SETD2
GO:0046328	regulation of JNK cascade	0.01839599038682576	0.01839599038682576	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:0043030	regulation of macrophage activation	0.01839599038682576	0.01839599038682576	+1	CEBPA,TLR4,MIR142
GO:2000243	positive regulation of reproductive process	0.01839599038682576	0.01839599038682576	+1	SOX9,WT1,ACVR1B
GO:0001649	osteoblast differentiation	0.01839599038682576	0.01839599038682576	+1	NF1,NOTCH1,HGF,FGFR2,ACVR2A
GO:0045839	negative regulation of mitotic nuclear division	0.01839599038682576	0.01839599038682576	+1	APC,ATM,ATRX
GO:1990845	adaptive thermogenesis	0.01883722113651103	0.01883722113651103	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:0046824	positive regulation of nucleocytoplasmic transport	0.019443628379813352	0.019443628379813352	+1	TP53,PIK3R1,CDH1
GO:0032206	positive regulation of telomere maintenance	0.019443628379813352	0.019443628379813352	+1	ATM,ATRX,ATR
GO:0048639	positive regulation of developmental growth	0.01956768856060696	0.01956768856060696	+1	NOTCH1,WT1,ERBB4,FGFR2
GO:0050769	positive regulation of neurogenesis	0.01973787624951607	0.01973787624951607	+1	NOTCH1,CTNNB1,ARHGAP35,EPHA3,EP300,SIN3A,MIR142
GO:0006109	regulation of carbohydrate metabolic process	0.019805953134274138	0.019805953134274138	+1	TP53,AKT1,EP300,FOXA2,NCOR1
GO:0007051	spindle organization	0.019805953134274138	0.019805953134274138	+1	STAG2,CHEK2,SMC1A,SMC3,NCOR1
GO:0001952	regulation of cell-matrix adhesion	0.020089819780699257	0.020089819780699257	+1	PTEN,NF1,CDKN2A,EPHA3
GO:1903203	regulation of oxidative stress-induced neuron death	0.020089819780699257	0.020089819780699257	+1	FBXW7,TLR4
GO:2000811	negative regulation of anoikis	0.020089819780699257	0.020089819780699257	+1	PIK3CA,NOTCH1
GO:0016584	nucleosome positioning	0.020089819780699257	0.020089819780699257	+1	CTCF,HIST1H1C
GO:0051444	negative regulation of ubiquitin-protein transferase activity	0.020089819780699257	0.020089819780699257	+1	CDKN2A,RPL5
GO:0098751	bone cell development	0.020089819780699257	0.020089819780699257	+1	FBXW7,KIT
GO:0071850	mitotic cell cycle arrest	0.020089819780699257	0.020089819780699257	+1	CDKN1B,CDKN1A
GO:0003338	metanephros morphogenesis	0.020089819780699257	0.020089819780699257	+1	SOX9,WT1
GO:0048103	somatic stem cell division	0.020089819780699257	0.020089819780699257	+1	CDKN2A,FGFR2
GO:2001022	positive regulation of response to DNA damage stimulus	0.020089819780699257	0.020089819780699257	+1	EGFR,ATM,BRCA1,ATR
GO:0048854	brain morphogenesis	0.020089819780699257	0.020089819780699257	+1	PTEN,NF1
GO:0001569	branching involved in blood vessel morphogenesis	0.020089819780699257	0.020089819780699257	+1	CTNNB1,TGFBR2
GO:0072111	cell proliferation involved in kidney development	0.020089819780699257	0.020089819780699257	+1	GATA3,WT1
GO:0009952	anterior/posterior pattern specification	0.020089819780699257	0.020089819780699257	+1	TBX3,WT1,FOXA2,SMAD2
GO:2000678	negative regulation of transcription regulatory region DNA binding	0.020089819780699257	0.020089819780699257	+1	TAF1,SIN3A
GO:0070201	regulation of establishment of protein localization	0.020180745222083046	0.020180745222083046	+1	TP53,PIK3R1,GATA3,FBXW7,CDH1,BAP1,TLR4,LRRK2,SETD2,FOXA2,MIR142
GO:0048839	inner ear development	0.020215205274908412	0.020215205274908412	+1	SOX9,FGFR2,PTPN11
GO:0001836	release of cytochrome c from mitochondria	0.020215205274908412	0.020215205274908412	+1	TP53,AKT1,HGF
GO:0070830	bicellular tight junction assembly	0.020215205274908412	0.020215205274908412	+1	APC,RUNX1,CBFB
GO:0044089	positive regulation of cellular component biogenesis	0.02030185266597985	0.02030185266597985	+1	TP53,APC,NAV3,ARHGAP35,AJUBA,ATM,TLR4,ATR,ERCC2
GO:0001101	response to acid chemical	0.02055663967669535	0.02055663967669535	+1	EPHA3,SOX9,ATM,MTOR,ASXL1
GO:0006473	protein acetylation	0.02055663967669535	0.02055663967669535	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:1902107	positive regulation of leukocyte differentiation	0.020622609561385622	0.020622609561385622	+1	GATA3,RUNX1,TGFBR2,CBFB
GO:0009266	response to temperature stimulus	0.021063599794230777	0.021063599794230777	+1	AKT1,ATM,MTOR,EP300,ATR
GO:0010810	regulation of cell-substrate adhesion	0.021063599794230777	0.021063599794230777	+1	PTEN,NF1,CDKN2A,NOTCH1,EPHA3
GO:0006913	nucleocytoplasmic transport	0.02118062541042154	0.02118062541042154	+1	TP53,PIK3R1,CDH1,NPM1,AKT1,U2AF1,SETD2
GO:0046323	glucose import	0.021185645367194708	0.021185645367194708	+1	PIK3R1,AKT1,PTPN11
GO:0060415	muscle tissue morphogenesis	0.021185645367194708	0.021185645367194708	+1	NOTCH1,FGFR2,SMAD4
GO:0048644	muscle organ morphogenesis	0.021185645367194708	0.021185645367194708	+1	NOTCH1,FGFR2,SMAD4
GO:0099565	chemical synaptic transmission, postsynaptic	0.021185645367194708	0.021185645367194708	+1	PTEN,AKT1,LRRK2
GO:0046631	alpha-beta T cell activation	0.021239514670834233	0.021239514670834233	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
GO:1902629	regulation of mRNA stability involved in cellular response to UV	0.021321622676910103	0.021321622676910103	+1	NPM1
GO:0045116	protein neddylation	0.021321622676910103	0.021321622676910103	+1	CDKN2A,RPL5
GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:1902298	cell cycle DNA replication maintenance of fidelity	0.021321622676910103	0.021321622676910103	+1	BRCA2
GO:0051169	nuclear transport	0.021321622676910103	0.021321622676910103	+1	TP53,PIK3R1,CDH1,NPM1,AKT1,U2AF1,SETD2
GO:1901984	negative regulation of protein acetylation	0.021321622676910103	0.021321622676910103	+1	BRCA1,SIN3A
GO:2000808	negative regulation of synaptic vesicle clustering	0.021321622676910103	0.021321622676910103	+1	PTEN
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0046605	regulation of centrosome cycle	0.021321622676910103	0.021321622676910103	+1	CTNNB1,NPM1,BRCA1
GO:0001659	temperature homeostasis	0.021321622676910103	0.021321622676910103	+1	APC,RB1,NOTCH1,STK11,TLR4
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	0.021321622676910103	0.021321622676910103	+1	APC,RB1,ATM
GO:0033260	nuclear DNA replication	0.021321622676910103	0.021321622676910103	+1	ATRX,CHEK2,BRCA2
GO:0018992	germ-line sex determination	0.021321622676910103	0.021321622676910103	+1	SOX9
GO:0019100	male germ-line sex determination	0.021321622676910103	0.021321622676910103	+1	SOX9
GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:1902178	fibroblast growth factor receptor apoptotic signaling pathway	0.021321622676910103	0.021321622676910103	+1	FGFR3
GO:0061032	visceral serous pericardium development	0.021321622676910103	0.021321622676910103	+1	WT1
GO:2000733	regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:2000702	regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:2000701	glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:2000699	fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:0060995	cell-cell signaling involved in kidney development	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:2000607	negative regulation of cell proliferation involved in mesonephros development	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:0071425	hematopoietic stem cell proliferation	0.021321622676910103	0.021321622676910103	+1	RUNX1,MECOM
GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	0.021321622676910103	0.021321622676910103	+1	RUNX1,TGFBR2,CBFB
GO:0060615	mammary gland bud formation	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0060807	regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification	0.021321622676910103	0.021321622676910103	+1	SOX17
GO:0060796	regulation of transcription involved in primary germ layer cell fate commitment	0.021321622676910103	0.021321622676910103	+1	SOX17
GO:0070413	trehalose metabolism in response to stress	0.021321622676910103	0.021321622676910103	+1	BRAF
GO:1905317	inferior endocardial cushion morphogenesis	0.021321622676910103	0.021321622676910103	+1	TGFBR2
GO:1905305	negative regulation of cardiac myofibril assembly	0.021321622676910103	0.021321622676910103	+1	SMAD4
GO:0060784	regulation of cell proliferation involved in tissue homeostasis	0.021321622676910103	0.021321622676910103	+1	SOX9
GO:1905304	regulation of cardiac myofibril assembly	0.021321622676910103	0.021321622676910103	+1	SMAD4
GO:1905277	negative regulation of epithelial tube formation	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:1903217	negative regulation of protein processing involved in protein targeting to mitochondrion	0.021321622676910103	0.021321622676910103	+1	LRRK2
GO:0060638	mesenchymal-epithelial cell signaling	0.021321622676910103	0.021321622676910103	+1	HGF
GO:0031398	positive regulation of protein ubiquitination	0.021321622676910103	0.021321622676910103	+1	PTEN,FBXW7,BRCA1,LRRK2
GO:1905208	negative regulation of cardiocyte differentiation	0.021321622676910103	0.021321622676910103	+1	EGFR,SMAD4
GO:0060648	mammary gland bud morphogenesis	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0030336	negative regulation of cell migration	0.021321622676910103	0.021321622676910103	+1	PTEN,NAV3,NF1,NOTCH1,CDH1,AKT1,EPPK1
GO:1904887	Wnt signalosome assembly	0.021321622676910103	0.021321622676910103	+1	LRRK2
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	0.021321622676910103	0.021321622676910103	+1	HGF
GO:0060667	branch elongation involved in salivary gland morphogenesis	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0060670	branching involved in labyrinthine layer morphogenesis	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA	0.021321622676910103	0.021321622676910103	+1	NPM1
GO:1905268	negative regulation of chromatin organization	0.021321622676910103	0.021321622676910103	+1	BRCA1,HIST1H1C,SIN3A
GO:1903216	regulation of protein processing involved in protein targeting to mitochondrion	0.021321622676910103	0.021321622676910103	+1	LRRK2
GO:0030177	positive regulation of Wnt signaling pathway	0.021321622676910103	0.021321622676910103	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
GO:0060843	venous endothelial cell differentiation	0.021321622676910103	0.021321622676910103	+1	NOTCH1
GO:2000469	negative regulation of peroxidase activity	0.021321622676910103	0.021321622676910103	+1	LRRK2
GO:0021769	orbitofrontal cortex development	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0072299	negative regulation of metanephric glomerulus development	0.021321622676910103	0.021321622676910103	+1	WT1
GO:1902884	positive regulation of response to oxidative stress	0.021321622676910103	0.021321622676910103	+1	FBXW7,TLR4
GO:0021879	forebrain neuron differentiation	0.021321622676910103	0.021321622676910103	+1	ERBB4,FGFR2
GO:0021896	forebrain astrocyte differentiation	0.021321622676910103	0.021321622676910103	+1	NF1
GO:0021897	forebrain astrocyte development	0.021321622676910103	0.021321622676910103	+1	NF1
GO:2000047	regulation of cell-cell adhesion mediated by cadherin	0.021321622676910103	0.021321622676910103	+1	FOXA1,FOXA2
GO:1990505	mitotic DNA replication maintenance of fidelity	0.021321622676910103	0.021321622676910103	+1	BRCA2
GO:1990426	mitotic recombination-dependent replication fork processing	0.021321622676910103	0.021321622676910103	+1	BRCA2
GO:1990248	regulation of transcription from RNA polymerase II promoter in response to DNA damage	0.021321622676910103	0.021321622676910103	+1	TP53
GO:1905929	positive regulation of invadopodium disassembly	0.021321622676910103	0.021321622676910103	+1	NAV3
GO:0032275	luteinizing hormone secretion	0.021321622676910103	0.021321622676910103	+1	TBX3
GO:1905927	regulation of invadopodium disassembly	0.021321622676910103	0.021321622676910103	+1	NAV3
GO:1903123	regulation of thioredoxin peroxidase activity	0.021321622676910103	0.021321622676910103	+1	LRRK2
GO:1903124	negative regulation of thioredoxin peroxidase activity	0.021321622676910103	0.021321622676910103	+1	LRRK2
GO:1903125	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation	0.021321622676910103	0.021321622676910103	+1	LRRK2
GO:1905878	invadopodium disassembly	0.021321622676910103	0.021321622676910103	+1	NAV3
GO:0060915	mesenchymal cell differentiation involved in lung development	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:1905856	negative regulation of pentose-phosphate shunt	0.021321622676910103	0.021321622676910103	+1	TP53
GO:0030071	regulation of mitotic metaphase/anaphase transition	0.021321622676910103	0.021321622676910103	+1	APC,RB1,ATM
GO:2000606	regulation of cell proliferation involved in mesonephros development	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:0060526	prostate glandular acinus morphogenesis	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0050712	negative regulation of interleukin-1 alpha secretion	0.021321622676910103	0.021321622676910103	+1	MIR142
GO:2000971	negative regulation of detection of glucose	0.021321622676910103	0.021321622676910103	+1	FOXA2
GO:0097306	cellular response to alcohol	0.021321622676910103	0.021321622676910103	+1	CTNNB1,CDH1,BRCA1
GO:0003213	cardiac right atrium morphogenesis	0.021321622676910103	0.021321622676910103	+1	NOTCH1
GO:0097326	melanocyte adhesion	0.021321622676910103	0.021321622676910103	+1	KIT
GO:0043433	negative regulation of DNA-binding transcription factor activity	0.021321622676910103	0.021321622676910103	+1	CDKN2A,RB1,KEAP1,FOXA2,TAF1
GO:0097393	telomeric repeat-containing RNA transcription	0.021321622676910103	0.021321622676910103	+1	ATRX
GO:0097394	telomeric repeat-containing RNA transcription by RNA polymerase II	0.021321622676910103	0.021321622676910103	+1	ATRX
GO:0008543	fibroblast growth factor receptor signaling pathway	0.021321622676910103	0.021321622676910103	+1	GATA3,FGFR2,FGFR3,PTPN11
GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	0.021321622676910103	0.021321622676910103	+1	FOXA2
GO:1904262	negative regulation of TORC1 signaling	0.021321622676910103	0.021321622676910103	+1	STK11,ATM
GO:0100002	negative regulation of protein kinase activity by protein phosphorylation	0.021321622676910103	0.021321622676910103	+1	AKT1
GO:0035607	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0061986	negative regulation of transcription by glucose	0.021321622676910103	0.021321622676910103	+1	FOXA2
GO:2000970	regulation of detection of glucose	0.021321622676910103	0.021321622676910103	+1	FOXA2
GO:0035604	fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0035603	fibroblast growth factor receptor signaling pathway involved in hemopoiesis	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0035602	fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0003002	regionalization	0.021321622676910103	0.021321622676910103	+1	TBX3,WT1,FGFR2,FOXA2,SMAD2
GO:0007542	primary sex determination, germ-line	0.021321622676910103	0.021321622676910103	+1	SOX9
GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation	0.021321622676910103	0.021321622676910103	+1	WT1
GO:0003251	positive regulation of cell proliferation involved in heart valve morphogenesis	0.021321622676910103	0.021321622676910103	+1	SMAD4
GO:0045951	positive regulation of mitotic recombination	0.021321622676910103	0.021321622676910103	+1	ERCC2
GO:0006306	DNA methylation	0.021321622676910103	0.021321622676910103	+1	DNMT3A,WT1,ATRX
GO:0051570	regulation of histone H3-K9 methylation	0.021321622676910103	0.021321622676910103	+1	ATRX,BRCA1
GO:0072428	signal transduction involved in intra-S DNA damage checkpoint	0.021321622676910103	0.021321622676910103	+1	CHEK2
GO:0072175	epithelial tube formation	0.021321622676910103	0.021321622676910103	+1	GATA3,SOX9,FGFR2
GO:0070510	regulation of histone H4-K20 methylation	0.021321622676910103	0.021321622676910103	+1	BRCA1
GO:0006305	DNA alkylation	0.021321622676910103	0.021321622676910103	+1	DNMT3A,WT1,ATRX
GO:0048713	regulation of oligodendrocyte differentiation	0.021321622676910103	0.021321622676910103	+1	NF1,NOTCH1
GO:0070512	positive regulation of histone H4-K20 methylation	0.021321622676910103	0.021321622676910103	+1	BRCA1
GO:0040030	regulation of molecular function, epigenetic	0.021321622676910103	0.021321622676910103	+1	CTCF
GO:0043065	positive regulation of apoptotic process	0.021321622676910103	0.021321622676910103	+1	TP53,PTEN,APC,NF1,CDKN2A,NOTCH1,FBXW7,CTNNB1,ATM,FOXA1
GO:0045687	positive regulation of glial cell differentiation	0.021321622676910103	0.021321622676910103	+1	NOTCH1,MIR142
GO:0036475	neuron death in response to oxidative stress	0.021321622676910103	0.021321622676910103	+1	FBXW7,TLR4
GO:0072012	glomerulus vasculature development	0.021321622676910103	0.021321622676910103	+1	WT1,PDGFRA
GO:0055017	cardiac muscle tissue growth	0.021321622676910103	0.021321622676910103	+1	NOTCH1,ERBB4,FGFR2
GO:0003415	chondrocyte hypertrophy	0.021321622676910103	0.021321622676910103	+1	SOX9
GO:0007221	positive regulation of transcription of Notch receptor target	0.021321622676910103	0.021321622676910103	+1	NOTCH1,EP300
GO:0007264	small GTPase mediated signal transduction	0.021321622676910103	0.021321622676910103	+1	TP53,KRAS,NF1,CDKN2A,RB1,NOTCH1,ARHGAP35,NRAS,CDKN1A
GO:0070373	negative regulation of ERK1 and ERK2 cascade	0.021321622676910103	0.021321622676910103	+1	PTEN,TLR4,SMAD4
GO:0061921	peptidyl-lysine propionylation	0.021321622676910103	0.021321622676910103	+1	EP300
GO:0003142	cardiogenic plate morphogenesis	0.021321622676910103	0.021321622676910103	+1	SOX17
GO:0120192	tight junction assembly	0.021321622676910103	0.021321622676910103	+1	APC,RUNX1,CBFB
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	0.021321622676910103	0.021321622676910103	+1	CTNNB1
GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	0.021321622676910103	0.021321622676910103	+1	CTNNB1
GO:0051138	positive regulation of NK T cell differentiation	0.021321622676910103	0.021321622676910103	+1	TGFBR2
GO:1901580	regulation of telomeric RNA transcription from RNA pol II promoter	0.021321622676910103	0.021321622676910103	+1	ATRX
GO:1901581	negative regulation of telomeric RNA transcription from RNA pol II promoter	0.021321622676910103	0.021321622676910103	+1	ATRX
GO:1901582	positive regulation of telomeric RNA transcription from RNA pol II promoter	0.021321622676910103	0.021321622676910103	+1	ATRX
GO:0072204	cell-cell signaling involved in metanephros development	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:1900260	negative regulation of RNA-directed 5'-3' RNA polymerase activity	0.021321622676910103	0.021321622676910103	+1	EIF4A2
GO:1900259	regulation of RNA-directed 5'-3' RNA polymerase activity	0.021321622676910103	0.021321622676910103	+1	EIF4A2
GO:1901675	negative regulation of histone H3-K27 acetylation	0.021321622676910103	0.021321622676910103	+1	SIN3A
GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:0060463	lung lobe morphogenesis	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0060516	primary prostatic bud elongation	0.021321622676910103	0.021321622676910103	+1	SOX9
GO:0060462	lung lobe development	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0060449	bud elongation involved in lung branching	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0060517	epithelial cell proliferation involved in prostatic bud elongation	0.021321622676910103	0.021321622676910103	+1	SOX9
GO:0060523	prostate epithelial cord elongation	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0140067	peptidyl-lysine butyrylation	0.021321622676910103	0.021321622676910103	+1	EP300
GO:0002649	regulation of tolerance induction to self antigen	0.021321622676910103	0.021321622676910103	+1	TGFBR2
GO:0002651	positive regulation of tolerance induction to self antigen	0.021321622676910103	0.021321622676910103	+1	TGFBR2
GO:0035315	hair cell differentiation	0.021321622676910103	0.021321622676910103	+1	CTNNB1,ERCC2
GO:0060525	prostate glandular acinus development	0.021321622676910103	0.021321622676910103	+1	FGFR2
GO:0061289	Wnt signaling pathway involved in kidney development	0.021321622676910103	0.021321622676910103	+1	GATA3
GO:0010498	proteasomal protein catabolic process	0.021321622676910103	0.021321622676910103	+1	FBXW7,CTNNB1,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,TBL1XR1,SPOP
GO:0032869	cellular response to insulin stimulus	0.021591727125026754	0.021591727125026754	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0007052	mitotic spindle organization	0.022025639295535783	0.022025639295535783	+1	STAG2,CHEK2,SMC1A,SMC3
GO:0045216	cell-cell junction organization	0.022117205329450693	0.022117205329450693	+1	APC,CTNNB1,CDH1,RUNX1,CBFB
GO:0048636	positive regulation of muscle organ development	0.022291420546403644	0.022291420546403644	+1	NOTCH1,ERBB4,FGFR2
GO:0051784	negative regulation of nuclear division	0.022291420546403644	0.022291420546403644	+1	APC,ATM,ATRX
GO:0045844	positive regulation of striated muscle tissue development	0.022291420546403644	0.022291420546403644	+1	NOTCH1,ERBB4,FGFR2
GO:0051145	smooth muscle cell differentiation	0.022291420546403644	0.022291420546403644	+1	NOTCH1,KIT,FGFR2
GO:0048662	negative regulation of smooth muscle cell proliferation	0.022291420546403644	0.022291420546403644	+1	PTEN,CDKN1B,CDKN1A
GO:0001819	positive regulation of cytokine production	0.022291420546403644	0.022291420546403644	+1	GATA3,CTNNB1,RUNX1,TLR4,BRCA1,SETD2,EP300,PTPN11
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	0.022291420546403644	0.022291420546403644	+1	APC,RB1,ATM
GO:0001817	regulation of cytokine production	0.02237538106373327	0.02237538106373327	+1	NAV3,GATA3,CTNNB1,RUNX1,TLR4,BRCA1,SETD2,EP300,SMAD4,PTPN11,MIR142
GO:0055003	cardiac myofibril assembly	0.022401144424515226	0.022401144424515226	+1	PDGFRA,SMAD4
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	0.022401144424515226	0.022401144424515226	+1	TP53,TAF1
GO:0006740	NADPH regeneration	0.022401144424515226	0.022401144424515226	+1	TP53,IDH1
GO:0061440	kidney vasculature development	0.022401144424515226	0.022401144424515226	+1	WT1,PDGFRA
GO:0061437	renal system vasculature development	0.022401144424515226	0.022401144424515226	+1	WT1,PDGFRA
GO:0048710	regulation of astrocyte differentiation	0.022401144424515226	0.022401144424515226	+1	NOTCH1,MIR142
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.022401144424515226	0.022401144424515226	+1	NFE2L2,AKT1
GO:1903038	negative regulation of leukocyte cell-cell adhesion	0.022516696949379703	0.022516696949379703	+1	CDKN2A,RUNX1,AKT1,CBFB
GO:0120193	tight junction organization	0.023199679308821795	0.023199679308821795	+1	APC,RUNX1,CBFB
GO:0055006	cardiac cell development	0.023199679308821795	0.023199679308821795	+1	NOTCH1,PDGFRA,SMAD4
GO:0016331	morphogenesis of embryonic epithelium	0.023199679308821795	0.023199679308821795	+1	GATA3,SOX9,FGFR2
GO:0044784	metaphase/anaphase transition of cell cycle	0.023199679308821795	0.023199679308821795	+1	APC,RB1,ATM
GO:0006354	DNA-templated transcription, elongation	0.023199679308821795	0.023199679308821795	+1	PBRM1,SETD2,CDK12,ERCC2
GO:1901863	positive regulation of muscle tissue development	0.023199679308821795	0.023199679308821795	+1	NOTCH1,ERBB4,FGFR2
GO:0051250	negative regulation of lymphocyte activation	0.023199679308821795	0.023199679308821795	+1	CDKN2A,RUNX1,ATM,CBFB
GO:0051053	negative regulation of DNA metabolic process	0.023919707918337533	0.023919707918337533	+1	TP53,ATM,POLQ,HIST1H1C
GO:0060759	regulation of response to cytokine stimulus	0.02403009660553154	0.02403009660553154	+1	RUNX1,TLR4,CBFB,PTPN11,LIFR
GO:0072659	protein localization to plasma membrane	0.024072971357933605	0.024072971357933605	+1	EGFR,PIK3R1,CDH1,EPHA3,AKT1,AR
GO:0045861	negative regulation of proteolysis	0.024072971357933605	0.024072971357933605	+1	CDKN2A,AKT1,HGF,LRRK2,TAF1,RPL5
GO:0010965	regulation of mitotic sister chromatid separation	0.024282299671483255	0.024282299671483255	+1	APC,RB1,ATM
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	0.024282299671483255	0.024282299671483255	+1	TP53,STK11,EP300
GO:0070828	heterochromatin organization	0.024552631377282818	0.024552631377282818	+1	CDKN2A,MECOM
GO:0070723	response to cholesterol	0.024552631377282818	0.024552631377282818	+1	TGFBR2,SMAD2
GO:0045671	negative regulation of osteoclast differentiation	0.024552631377282818	0.024552631377282818	+1	FBXW7,TLR4
GO:0060964	regulation of gene silencing by miRNA	0.024552631377282818	0.024552631377282818	+1	TP53,EGFR,AJUBA,NCOR1
GO:0006337	nucleosome disassembly	0.024552631377282818	0.024552631377282818	+1	ARID1A,PBRM1
GO:0030277	maintenance of gastrointestinal epithelium	0.024552631377282818	0.024552631377282818	+1	SOX9,TLR4
GO:0001709	cell fate determination	0.024552631377282818	0.024552631377282818	+1	GATA3,SOX17
GO:0046639	negative regulation of alpha-beta T cell differentiation	0.024552631377282818	0.024552631377282818	+1	RUNX1,CBFB
GO:1901983	regulation of protein acetylation	0.025241123889219307	0.025241123889219307	+1	BRCA1,SMAD4,SIN3A
GO:0006644	phospholipid metabolic process	0.025241123889219307	0.025241123889219307	+1	PIK3CA,PTEN,PIK3R1,FLT3,PIK3CG,KIT,PDGFRA,FGFR3
GO:0043967	histone H4 acetylation	0.025241123889219307	0.025241123889219307	+1	BRCA1,EP300,BRCA2
GO:0043297	apical junction assembly	0.025241123889219307	0.025241123889219307	+1	APC,RUNX1,CBFB
GO:1903749	positive regulation of establishment of protein localization to mitochondrion	0.025241123889219307	0.025241123889219307	+1	TP53,FBXW7,BAP1
GO:0060541	respiratory system development	0.025241123889219307	0.025241123889219307	+1	CEBPA,WT1,FGFR2
GO:0044786	cell cycle DNA replication	0.025241123889219307	0.025241123889219307	+1	ATRX,CHEK2,BRCA2
GO:0072657	protein localization to membrane	0.025808576714202554	0.025808576714202554	+1	TP53,EGFR,PIK3R1,CDH1,RPL22,EPHA3,AKT1,BRAF,AR,RPL5
GO:0060966	regulation of gene silencing by RNA	0.025898535805836953	0.025898535805836953	+1	TP53,EGFR,AJUBA,NCOR1
GO:0006289	nucleotide-excision repair	0.025898535805836953	0.025898535805836953	+1	TP53,EP300,BRCA2,ERCC2
GO:0009267	cellular response to starvation	0.025898535805836953	0.025898535805836953	+1	TP53,MTOR,LRRK2,CDKN1A
GO:0060147	regulation of posttranscriptional gene silencing	0.025898535805836953	0.025898535805836953	+1	TP53,EGFR,AJUBA,NCOR1
GO:0051306	mitotic sister chromatid separation	0.026334749393697187	0.026334749393697187	+1	APC,RB1,ATM
GO:1900182	positive regulation of protein localization to nucleus	0.026334749393697187	0.026334749393697187	+1	PIK3R1,CDH1,AKT1
GO:0010812	negative regulation of cell-substrate adhesion	0.026334749393697187	0.026334749393697187	+1	PTEN,CDKN2A,NOTCH1
GO:0007005	mitochondrion organization	0.026433791555392643	0.026433791555392643	+1	TP53,CDKN2A,FBXW7,BAP1,AKT1,HGF,ERBB4,LRRK2,EP300
GO:0021955	central nervous system neuron axonogenesis	0.02675905959727986	0.02675905959727986	+1	PTEN,ARHGAP35
GO:0048566	embryonic digestive tract development	0.02675905959727986	0.02675905959727986	+1	PDGFRA,FGFR2
GO:0003272	endocardial cushion formation	0.02675905959727986	0.02675905959727986	+1	NOTCH1,TGFBR2
GO:0030851	granulocyte differentiation	0.02675905959727986	0.02675905959727986	+1	RUNX1,CEBPA
GO:2000810	regulation of bicellular tight junction assembly	0.02675905959727986	0.02675905959727986	+1	RUNX1,CBFB
GO:0007095	mitotic G2 DNA damage checkpoint	0.02675905959727986	0.02675905959727986	+1	ATM,CDKN1A
GO:0120035	regulation of plasma membrane bounded cell projection organization	0.02700018450105412	0.02700018450105412	+1	PTEN,APC,NAV3,ARHGAP35,EPHA3,AKT1,LRRK2,EP300,SIN3A
GO:0031667	response to nutrient levels	0.02700018450105412	0.02700018450105412	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
GO:0032388	positive regulation of intracellular transport	0.02706976182138999	0.02706976182138999	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1
GO:0032868	response to insulin	0.02706976182138999	0.02706976182138999	+1	PIK3CA,APC,PIK3R1,AKT1,PTPN11
GO:0042177	negative regulation of protein catabolic process	0.027276311508303903	0.027276311508303903	+1	EGFR,CDKN2A,TAF1,RPL5
GO:0034605	cellular response to heat	0.027276311508303903	0.027276311508303903	+1	ATM,MTOR,EP300,ATR
GO:0044255	cellular lipid metabolic process	0.027838681049866275	0.027838681049866275	+1	PIK3CA,PTEN,PIK3R1,FBXW7,FLT3,AKT1,PIK3CG,BRCA1,KIT,PDGFRA,FGFR3,B4GALT3,PPP2R1A,NCOR1
GO:0060249	anatomical structure homeostasis	0.027987978630120633	0.027987978630120633	+1	NF1,NOTCH1,SOX9,ATM,TLR4,ATRX,ATR
GO:0006334	nucleosome assembly	0.028069673009720592	0.028069673009720592	+1	NPM1,SOX9,ATRX,HIST1H2BD
GO:0051962	positive regulation of nervous system development	0.028407716947099912	0.028407716947099912	+1	NOTCH1,CTNNB1,ARHGAP35,EPHA3,EP300,SIN3A,MIR142
GO:2000573	positive regulation of DNA biosynthetic process	0.028516740190597967	0.028516740190597967	+1	ATM,HGF,ATR
GO:1905818	regulation of chromosome separation	0.028516740190597967	0.028516740190597967	+1	APC,RB1,ATM
GO:0060349	bone morphogenesis	0.028516740190597967	0.028516740190597967	+1	SOX9,FGFR2,FGFR3
GO:0006661	phosphatidylinositol biosynthetic process	0.028839701020942608	0.028839701020942608	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
GO:0031344	regulation of cell projection organization	0.028898816312619452	0.028898816312619452	+1	PTEN,APC,NAV3,ARHGAP35,EPHA3,AKT1,LRRK2,EP300,SIN3A
GO:0009299	mRNA transcription	0.028923851696960743	0.028923851696960743	+1	TP53,SOX17
GO:0032069	regulation of nuclease activity	0.028923851696960743	0.028923851696960743	+1	NPM1,AKT1
GO:2000209	regulation of anoikis	0.028923851696960743	0.028923851696960743	+1	PIK3CA,NOTCH1
GO:0031498	chromatin disassembly	0.028923851696960743	0.028923851696960743	+1	ARID1A,PBRM1
GO:0032986	protein-DNA complex disassembly	0.028923851696960743	0.028923851696960743	+1	ARID1A,PBRM1
GO:0033233	regulation of protein sumoylation	0.028923851696960743	0.028923851696960743	+1	CDKN2A,CTNNB1
GO:0008380	RNA splicing	0.028923851696960743	0.028923851696960743	+1	PIK3R1,WT1,PRX,U2AF1,SF3B1,PPP2R1A,CDK12,PCBP1
GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	0.028923851696960743	0.028923851696960743	+1	VHL,PPP2R1A
GO:1901798	positive regulation of signal transduction by p53 class mediator	0.028923851696960743	0.028923851696960743	+1	ATM,ATR
GO:0002183	cytoplasmic translational initiation	0.028923851696960743	0.028923851696960743	+1	MTOR,EIF4A2
GO:0071459	protein localization to chromosome, centromeric region	0.028923851696960743	0.028923851696960743	+1	RB1,CTCF
GO:1904886	beta-catenin destruction complex disassembly	0.028923851696960743	0.028923851696960743	+1	APC,CTNNB1
GO:0051222	positive regulation of protein transport	0.028999397892040413	0.028999397892040413	+1	TP53,PIK3R1,GATA3,FBXW7,CDH1,BAP1,TLR4
GO:0060078	regulation of postsynaptic membrane potential	0.02948711037810621	0.02948711037810621	+1	PTEN,AKT1,LRRK2
GO:0051298	centrosome duplication	0.02948711037810621	0.02948711037810621	+1	NPM1,BRCA1,BRCA2
GO:0070988	demethylation	0.02948711037810621	0.02948711037810621	+1	KDM5C,TET2,USP9X
GO:0007254	JNK cascade	0.029835878532038097	0.029835878532038097	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:2001236	regulation of extrinsic apoptotic signaling pathway	0.030222697593208753	0.030222697593208753	+1	PTEN,AKT1,AR,BRCA1
GO:0007098	centrosome cycle	0.030222697593208753	0.030222697593208753	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:1901224	positive regulation of NIK/NF-kappaB signaling	0.030700540733430103	0.030700540733430103	+1	EGFR,TLR4,EP300
GO:0030316	osteoclast differentiation	0.030700540733430103	0.030700540733430103	+1	FBXW7,MTOR,TLR4
GO:0006360	transcription by RNA polymerase I	0.030700540733430103	0.030700540733430103	+1	MTOR,TAF1,ERCC2
GO:0006413	translational initiation	0.031088964141123665	0.031088964141123665	+1	NPM1,RPL22,MTOR,EIF4A2,RPL5
GO:0010975	regulation of neuron projection development	0.031169310948054606	0.031169310948054606	+1	PTEN,ARHGAP35,EPHA3,AKT1,LRRK2,EP300,SIN3A
GO:0014741	negative regulation of muscle hypertrophy	0.03126122123428163	0.03126122123428163	+1	NOTCH1,SMAD4
GO:0048147	negative regulation of fibroblast proliferation	0.03126122123428163	0.03126122123428163	+1	TP53,NF1
GO:0045943	positive regulation of transcription by RNA polymerase I	0.03126122123428163	0.03126122123428163	+1	MTOR,TAF1
GO:0050869	negative regulation of B cell activation	0.03126122123428163	0.03126122123428163	+1	CDKN2A,ATM
GO:0010614	negative regulation of cardiac muscle hypertrophy	0.03126122123428163	0.03126122123428163	+1	NOTCH1,SMAD4
GO:0034405	response to fluid shear stress	0.03126122123428163	0.03126122123428163	+1	NFE2L2,AKT1
GO:0048384	retinoic acid receptor signaling pathway	0.03126122123428163	0.03126122123428163	+1	ASXL1,EZH2
GO:0046599	regulation of centriole replication	0.03126122123428163	0.03126122123428163	+1	NPM1,BRCA1
GO:1901652	response to peptide	0.03148101526371051	0.03148101526371051	+1	TP53,PIK3CA,APC,PIK3R1,AKT1,TLR4,PTPN11
GO:0060389	pathway-restricted SMAD protein phosphorylation	0.03177835743401933	0.03177835743401933	+1	SMAD4,TGFBR2,ACVR2A
GO:0014013	regulation of gliogenesis	0.03177835743401933	0.03177835743401933	+1	NF1,NOTCH1,MIR142
GO:0070301	cellular response to hydrogen peroxide	0.03177835743401933	0.03177835743401933	+1	NFE2L2,HGF,LRRK2
GO:0007369	gastrulation	0.03260101605772334	0.03260101605772334	+1	SETD2,FOXA2,SOX17,SMAD2
GO:0045664	regulation of neuron differentiation	0.03292602281458178	0.03292602281458178	+1	PTEN,ARHGAP35,EPHA3,AKT1,SOX9,LRRK2,EP300,SIN3A
GO:0035924	cellular response to vascular endothelial growth factor stimulus	0.03303529073987115	0.03303529073987115	+1	NOTCH1,PDGFRA,EGR3
GO:0071887	leukocyte apoptotic process	0.03303529073987115	0.03303529073987115	+1	TP53,CDKN2A,AKT1
GO:1903051	negative regulation of proteolysis involved in cellular protein catabolic process	0.03303529073987115	0.03303529073987115	+1	CDKN2A,TAF1,RPL5
GO:0021782	glial cell development	0.03303529073987115	0.03303529073987115	+1	PTEN,NF1,MIR142
GO:0071229	cellular response to acid chemical	0.03341578165309901	0.03341578165309901	+1	EPHA3,SOX9,ATM,MTOR
GO:0010669	epithelial structure maintenance	0.03356324677587363	0.03356324677587363	+1	SOX9,TLR4
GO:0051567	histone H3-K9 methylation	0.03356324677587363	0.03356324677587363	+1	ATRX,BRCA1
GO:2000108	positive regulation of leukocyte apoptotic process	0.03356324677587363	0.03356324677587363	+1	TP53,CDKN2A
GO:0007026	negative regulation of microtubule depolymerization	0.03356324677587363	0.03356324677587363	+1	APC,NAV3
GO:0110150	negative regulation of biomineralization	0.03356324677587363	0.03356324677587363	+1	NOTCH1,SOX9
GO:0032727	positive regulation of interferon-alpha production	0.03356324677587363	0.03356324677587363	+1	TLR4,SETD2
GO:0035066	positive regulation of histone acetylation	0.03356324677587363	0.03356324677587363	+1	BRCA1,SMAD4
GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	0.03356324677587363	0.03356324677587363	+1	RUNX1,CBFB
GO:0014014	negative regulation of gliogenesis	0.03356324677587363	0.03356324677587363	+1	NF1,NOTCH1
GO:0070168	negative regulation of biomineral tissue development	0.03356324677587363	0.03356324677587363	+1	NOTCH1,SOX9
GO:1902751	positive regulation of cell cycle G2/M phase transition	0.03356324677587363	0.03356324677587363	+1	NPM1,CCND1
GO:0036314	response to sterol	0.03356324677587363	0.03356324677587363	+1	TGFBR2,SMAD2
GO:0060317	cardiac epithelial to mesenchymal transition	0.03356324677587363	0.03356324677587363	+1	NOTCH1,TGFBR2
GO:0043542	endothelial cell migration	0.034057871738202995	0.034057871738202995	+1	PIK3CA,NF1,GATA3,NOTCH1,AKT1,EGR3
GO:0010608	posttranscriptional regulation of gene expression	0.034375619793331244	0.034375619793331244	+1	TP53,EGFR,NPM1,AKT1,AJUBA,MTOR,EIF4A2,NCOR1,RPL5,SMAD2,AXIN2,MIR142
GO:0010389	regulation of G2/M transition of mitotic cell cycle	0.03465418639669166	0.03465418639669166	+1	CDKN2A,ATM,CCND1,CDKN1A,PPP2R1A
GO:0031347	regulation of defense response	0.0349295100982039	0.0349295100982039	+1	KRAS,GATA3,RB1,MAP3K1,NRAS,CEBPA,TLR4,EP300,SIN3A,PTPN11,MIR142
GO:0030510	regulation of BMP signaling pathway	0.035467889169446314	0.035467889169446314	+1	NOTCH1,SMAD4,SMAD2
GO:0016578	histone deubiquitination	0.03625453927571924	0.03625453927571924	+1	BAP1,ASXL1
GO:0021872	forebrain generation of neurons	0.03625453927571924	0.03625453927571924	+1	ERBB4,FGFR2
GO:0000729	DNA double-strand break processing	0.03625453927571924	0.03625453927571924	+1	ATM,BRCA1
GO:0051049	regulation of transport	0.03635325741877372	0.03635325741877372	+1	TP53,PTEN,PIK3R1,GATA3,NOTCH1,FBXW7,CTNNB1,CDH1,BAP1,EPHA3,AKT1,BRAF,TLR4,LRRK2,SETD2,FOXA2,PTPN11,MAPK8IP1,MIR142
GO:0097324	melanocyte migration	0.036504006548602086	0.036504006548602086	+1	KIT
GO:0051865	protein autoubiquitination	0.036504006548602086	0.036504006548602086	+1	BRCA1,LRRK2,TAF1
GO:0060326	cell chemotaxis	0.036504006548602086	0.036504006548602086	+1	NOTCH1,PIK3CG,HGF,KIT,PDGFRA,EGR3
GO:0048617	embryonic foregut morphogenesis	0.036504006548602086	0.036504006548602086	+1	SOX17
GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	0.036504006548602086	0.036504006548602086	+1	NOTCH1
GO:0000187	activation of MAPK activity	0.036504006548602086	0.036504006548602086	+1	MAP2K4,TLR4,LRRK2,KIT
GO:0071866	negative regulation of apoptotic process in bone marrow cell	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:0048866	stem cell fate specification	0.036504006548602086	0.036504006548602086	+1	SOX9
GO:0006407	rRNA export from nucleus	0.036504006548602086	0.036504006548602086	+1	NPM1
GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	0.036504006548602086	0.036504006548602086	+1	ASXL1
GO:0050705	regulation of interleukin-1 alpha secretion	0.036504006548602086	0.036504006548602086	+1	MIR142
GO:0005991	trehalose metabolic process	0.036504006548602086	0.036504006548602086	+1	BRAF
GO:0072034	renal vesicle induction	0.036504006548602086	0.036504006548602086	+1	SOX9
GO:0045720	negative regulation of integrin biosynthetic process	0.036504006548602086	0.036504006548602086	+1	AR
GO:0072166	posterior mesonephric tubule development	0.036504006548602086	0.036504006548602086	+1	WT1
GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling	0.036504006548602086	0.036504006548602086	+1	EGFR
GO:0072301	regulation of metanephric glomerular mesangial cell proliferation	0.036504006548602086	0.036504006548602086	+1	WT1
GO:0003220	left ventricular cardiac muscle tissue morphogenesis	0.036504006548602086	0.036504006548602086	+1	SMAD4
GO:0003006	developmental process involved in reproduction	0.036504006548602086	0.036504006548602086	+1	GATA3,TBX3,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
GO:0099404	mitotic sister chromatid cohesion, telomeric	0.036504006548602086	0.036504006548602086	+1	ATRX
GO:0045976	negative regulation of mitotic cell cycle, embryonic	0.036504006548602086	0.036504006548602086	+1	CTNNB1
GO:0007584	response to nutrient	0.036504006548602086	0.036504006548602086	+1	MTOR,FOXA2,TAF1
GO:0097156	fasciculation of motor neuron axon	0.036504006548602086	0.036504006548602086	+1	EPHA3
GO:0008544	epidermis development	0.036504006548602086	0.036504006548602086	+1	CTNNB1,RUNX1,SOX9,ELF3,FGFR2,CBFB,ERCC2
GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	0.036504006548602086	0.036504006548602086	+1	CTNNB1
GO:0035801	adrenal cortex development	0.036504006548602086	0.036504006548602086	+1	WT1
GO:0043974	histone H3-K27 acetylation	0.036504006548602086	0.036504006548602086	+1	SIN3A
GO:0007538	primary sex determination	0.036504006548602086	0.036504006548602086	+1	SOX9
GO:0003169	coronary vein morphogenesis	0.036504006548602086	0.036504006548602086	+1	NOTCH1
GO:0007440	foregut morphogenesis	0.036504006548602086	0.036504006548602086	+1	SOX17
GO:0060056	mammary gland involution	0.036504006548602086	0.036504006548602086	+1	ELF3
GO:0060024	rhythmic synaptic transmission	0.036504006548602086	0.036504006548602086	+1	PTEN
GO:0043969	histone H2B acetylation	0.036504006548602086	0.036504006548602086	+1	EP300
GO:0007182	common-partner SMAD protein phosphorylation	0.036504006548602086	0.036504006548602086	+1	SMAD2
GO:0002661	regulation of B cell tolerance induction	0.036504006548602086	0.036504006548602086	+1	TGFBR2
GO:0071372	cellular response to follicle-stimulating hormone stimulus	0.036504006548602086	0.036504006548602086	+1	NOTCH1
GO:0002663	positive regulation of B cell tolerance induction	0.036504006548602086	0.036504006548602086	+1	TGFBR2
GO:0099403	maintenance of mitotic sister chromatid cohesion, telomeric	0.036504006548602086	0.036504006548602086	+1	ATRX
GO:0007352	zygotic specification of dorsal/ventral axis	0.036504006548602086	0.036504006548602086	+1	SMAD2
GO:0035802	adrenal cortex formation	0.036504006548602086	0.036504006548602086	+1	WT1
GO:0021860	pyramidal neuron development	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:0140066	peptidyl-lysine crotonylation	0.036504006548602086	0.036504006548602086	+1	EP300
GO:1903463	regulation of mitotic cell cycle DNA replication	0.036504006548602086	0.036504006548602086	+1	CHEK2
GO:1903464	negative regulation of mitotic cell cycle DNA replication	0.036504006548602086	0.036504006548602086	+1	CHEK2
GO:0060594	mammary gland specification	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:0060592	mammary gland formation	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:0060767	epithelial cell proliferation involved in prostate gland development	0.036504006548602086	0.036504006548602086	+1	SOX9
GO:1904908	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	0.036504006548602086	0.036504006548602086	+1	ATRX
GO:2000346	negative regulation of hepatocyte proliferation	0.036504006548602086	0.036504006548602086	+1	FBXW7
GO:0060572	morphogenesis of an epithelial bud	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:1901674	regulation of histone H3-K27 acetylation	0.036504006548602086	0.036504006548602086	+1	SIN3A
GO:1904907	regulation of maintenance of mitotic sister chromatid cohesion, telomeric	0.036504006548602086	0.036504006548602086	+1	ATRX
GO:2000683	regulation of cellular response to X-ray	0.036504006548602086	0.036504006548602086	+1	GATA3
GO:0060484	lung-associated mesenchyme development	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:0016046	detection of fungus	0.036504006548602086	0.036504006548602086	+1	TLR4
GO:0021869	forebrain ventricular zone progenitor cell division	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:0016458	gene silencing	0.036504006548602086	0.036504006548602086	+1	TP53,EGFR,AJUBA,HIST1H1C,SIN3A,NCOR1,SMAD2,MIR142,EZH2
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:2001076	positive regulation of metanephric ureteric bud development	0.036504006548602086	0.036504006548602086	+1	WT1
GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	0.036504006548602086	0.036504006548602086	+1	FBXW7
GO:0060948	cardiac vascular smooth muscle cell development	0.036504006548602086	0.036504006548602086	+1	NOTCH1
GO:0060601	lateral sprouting from an epithelium	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:0046632	alpha-beta T cell differentiation	0.036504006548602086	0.036504006548602086	+1	RUNX1,TGFBR2,CBFB
GO:1990874	vascular smooth muscle cell proliferation	0.036504006548602086	0.036504006548602086	+1	PTEN,CDKN1B,CDKN1A
GO:0060916	mesenchymal cell proliferation involved in lung development	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:1905863	invadopodium organization	0.036504006548602086	0.036504006548602086	+1	NAV3
GO:2001074	regulation of metanephric ureteric bud development	0.036504006548602086	0.036504006548602086	+1	WT1
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:1901963	regulation of cell proliferation involved in outflow tract morphogenesis	0.036504006548602086	0.036504006548602086	+1	CTNNB1
GO:0030193	regulation of blood coagulation	0.036504006548602086	0.036504006548602086	+1	TLR4,PDGFRA,FOXA2
GO:0061031	endodermal digestive tract morphogenesis	0.036504006548602086	0.036504006548602086	+1	SOX17
GO:0030218	erythrocyte differentiation	0.036504006548602086	0.036504006548602086	+1	KIT,ACVR1B,ACVR2A
GO:1903336	negative regulation of vacuolar transport	0.036504006548602086	0.036504006548602086	+1	LRRK2
GO:1902499	positive regulation of protein autoubiquitination	0.036504006548602086	0.036504006548602086	+1	LRRK2
GO:1905524	negative regulation of protein autoubiquitination	0.036504006548602086	0.036504006548602086	+1	TAF1
GO:2000639	negative regulation of SREBP signaling pathway	0.036504006548602086	0.036504006548602086	+1	FBXW7
GO:1990418	response to insulin-like growth factor stimulus	0.036504006548602086	0.036504006548602086	+1	AKT1
GO:1904028	positive regulation of collagen fibril organization	0.036504006548602086	0.036504006548602086	+1	RB1
GO:0048339	paraxial mesoderm development	0.036504006548602086	0.036504006548602086	+1	SMAD2
GO:1904059	regulation of locomotor rhythm	0.036504006548602086	0.036504006548602086	+1	MTOR
GO:2000620	positive regulation of histone H4-K16 acetylation	0.036504006548602086	0.036504006548602086	+1	BRCA1
GO:0030901	midbrain development	0.036504006548602086	0.036504006548602086	+1	CTNNB1,FGFR2,TAF1
GO:0048340	paraxial mesoderm morphogenesis	0.036504006548602086	0.036504006548602086	+1	SMAD2
GO:1900046	regulation of hemostasis	0.036504006548602086	0.036504006548602086	+1	TLR4,PDGFRA,FOXA2
GO:1904466	positive regulation of matrix metallopeptidase secretion	0.036504006548602086	0.036504006548602086	+1	TLR4
GO:0021847	ventricular zone neuroblast division	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:0021551	central nervous system morphogenesis	0.036504006548602086	0.036504006548602086	+1	ERBB4
GO:0060442	branching involved in prostate gland morphogenesis	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:0060693	regulation of branching involved in salivary gland morphogenesis	0.036504006548602086	0.036504006548602086	+1	HGF
GO:0014036	neural crest cell fate specification	0.036504006548602086	0.036504006548602086	+1	SOX9
GO:1904761	negative regulation of myofibroblast differentiation	0.036504006548602086	0.036504006548602086	+1	RB1
GO:0021859	pyramidal neuron differentiation	0.036504006548602086	0.036504006548602086	+1	FGFR2
GO:0061890	positive regulation of astrocyte activation	0.036504006548602086	0.036504006548602086	+1	MIR142
GO:0010768	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	0.036504006548602086	0.036504006548602086	+1	TAF1
GO:2000195	negative regulation of female gonad development	0.036504006548602086	0.036504006548602086	+1	WT1
GO:1902823	negative regulation of late endosome to lysosome transport	0.036504006548602086	0.036504006548602086	+1	LRRK2
GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	0.036504006548602086	0.036504006548602086	+1	SMAD2
GO:1904705	regulation of vascular smooth muscle cell proliferation	0.036504006548602086	0.036504006548602086	+1	PTEN,CDKN1B,CDKN1A
GO:0002253	activation of immune response	0.03661057118341463	0.03661057118341463	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,TLR4,EP300,CBFB,SIN3A
GO:0031023	microtubule organizing center organization	0.03661057118341463	0.03661057118341463	+1	CTNNB1,NPM1,BRCA1,BRCA2
GO:0070231	T cell apoptotic process	0.03678653615031092	0.03678653615031092	+1	TP53,AKT1
GO:0045740	positive regulation of DNA replication	0.03678653615031092	0.03678653615031092	+1	EGFR,ATRX
GO:0045648	positive regulation of erythrocyte differentiation	0.03678653615031092	0.03678653615031092	+1	ACVR1B,ACVR2A
GO:0061311	cell surface receptor signaling pathway involved in heart development	0.03678653615031092	0.03678653615031092	+1	NOTCH1,CTNNB1
GO:0010837	regulation of keratinocyte proliferation	0.03678653615031092	0.03678653615031092	+1	EPPK1,TLR4
GO:0060260	regulation of transcription initiation from RNA polymerase II promoter	0.03678653615031092	0.03678653615031092	+1	TP53,TAF1
GO:0060173	limb development	0.03732279900522853	0.03732279900522853	+1	CTNNB1,TBX3,FGFR2
GO:0031058	positive regulation of histone modification	0.03732279900522853	0.03732279900522853	+1	CTNNB1,BRCA1,SMAD4
GO:0048736	appendage development	0.03732279900522853	0.03732279900522853	+1	CTNNB1,TBX3,FGFR2
GO:0045639	positive regulation of myeloid cell differentiation	0.03732279900522853	0.03732279900522853	+1	RUNX1,ACVR1B,ACVR2A
GO:0002695	negative regulation of leukocyte activation	0.0383278901965803	0.0383278901965803	+1	CDKN2A,RUNX1,ATM,CBFB
GO:0042594	response to starvation	0.0383278901965803	0.0383278901965803	+1	TP53,MTOR,LRRK2,CDKN1A
GO:1903533	regulation of protein targeting	0.038670488014788645	0.038670488014788645	+1	FBXW7,BAP1,LRRK2
GO:0034101	erythrocyte homeostasis	0.038670488014788645	0.038670488014788645	+1	KIT,ACVR1B,ACVR2A
GO:1902036	regulation of hematopoietic stem cell differentiation	0.038670488014788645	0.038670488014788645	+1	GATA3,RUNX1,CBFB
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	0.03922512526452403	0.03922512526452403	+1	TP53,WT1
GO:0017145	stem cell division	0.03922512526452403	0.03922512526452403	+1	CDKN2A,FGFR2
GO:0080111	DNA demethylation	0.03922512526452403	0.03922512526452403	+1	TET2,USP9X
GO:0046640	regulation of alpha-beta T cell proliferation	0.03922512526452403	0.03922512526452403	+1	TGFBR2,MAPK8IP1
GO:2000758	positive regulation of peptidyl-lysine acetylation	0.03922512526452403	0.03922512526452403	+1	BRCA1,SMAD4
GO:0050855	regulation of B cell receptor signaling pathway	0.03922512526452403	0.03922512526452403	+1	RUNX1,CBFB
GO:0043303	mast cell degranulation	0.03922512526452403	0.03922512526452403	+1	PIK3CG,KIT
GO:0051154	negative regulation of striated muscle cell differentiation	0.03922512526452403	0.03922512526452403	+1	NOTCH1,SMAD4
GO:0060765	regulation of androgen receptor signaling pathway	0.03922512526452403	0.03922512526452403	+1	EP300,NCOR1
GO:0061515	myeloid cell development	0.03922512526452403	0.03922512526452403	+1	FBXW7,KIT
GO:0030258	lipid modification	0.03939794157247935	0.03939794157247935	+1	PIK3CA,PTEN,PIK3R1,AKT1,PIK3CG
GO:0035710	CD4-positive, alpha-beta T cell activation	0.039859055730669155	0.039859055730669155	+1	RUNX1,TGFBR2,CBFB
GO:0043407	negative regulation of MAP kinase activity	0.039859055730669155	0.039859055730669155	+1	NF1,PPP2R1A,MAPK8IP1
GO:0043010	camera-type eye development	0.0399499495581433	0.0399499495581433	+1	NF1,SOX9,WT1,PDGFRA
GO:0043467	regulation of generation of precursor metabolites and energy	0.0399499495581433	0.0399499495581433	+1	TP53,AKT1,EP300,NCOR1
GO:0051179	localization	0.040428602299281365	0.040428602299281365	+1	TP53,PIK3CA,PTEN,APC,NAV3,EGFR,NF1,PIK3R1,GATA3,RB1,NOTCH1,FBXW7,CTNNB1,KEAP1,CDH1,ARHGAP35,CTCF,BAP1,NPM1,NRAS,IDH1,TBX3,RPL22,EPHA3,AKT1,BRAF,AR,EPPK1,PIK3CG,SOX9,ATM,HGF,ERBB4,MTOR,TLR4,U2AF1,ATRX,LRRK2,KIT,SETD2,PDGFRA,FOXA2,USP9X,BRCA2,TGFBR2,PPP2R1A,ATR,SIN3A,PTPN11,ACVR1B,MAPK8IP1,EGR3,RPL5,AXIN2,MIR142,RAD21
GO:1990778	protein localization to cell periphery	0.040441284569228485	0.040441284569228485	+1	EGFR,PIK3R1,CDH1,EPHA3,AKT1,AR
GO:0031098	stress-activated protein kinase signaling cascade	0.040441284569228485	0.040441284569228485	+1	EGFR,MAP3K1,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:0002757	immune response-activating signal transduction	0.04045805163465732	0.04045805163465732	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,TLR4,EP300,CBFB
GO:0032872	regulation of stress-activated MAPK cascade	0.04078399064076662	0.04078399064076662	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:0000724	double-strand break repair via homologous recombination	0.040842652938666776	0.040842652938666776	+1	BRCA1,POLQ,SETD2,BRCA2
GO:0050818	regulation of coagulation	0.04110794987388305	0.04110794987388305	+1	TLR4,PDGFRA,FOXA2
GO:0002062	chondrocyte differentiation	0.04110794987388305	0.04110794987388305	+1	RUNX1,SOX9,FGFR3
GO:0035249	synaptic transmission, glutamatergic	0.04110794987388305	0.04110794987388305	+1	TSHZ3,LRRK2,MIR142
GO:0001942	hair follicle development	0.04144372991574852	0.04144372991574852	+1	SOX9,FGFR2
GO:0000725	recombinational repair	0.04144372991574852	0.04144372991574852	+1	BRCA1,POLQ,SETD2,BRCA2
GO:1904893	negative regulation of receptor signaling pathway via STAT	0.04144372991574852	0.04144372991574852	+1	VHL,PPP2R1A
GO:0042472	inner ear morphogenesis	0.04144372991574852	0.04144372991574852	+1	SOX9,FGFR2
GO:0045429	positive regulation of nitric oxide biosynthetic process	0.04144372991574852	0.04144372991574852	+1	AKT1,TLR4
GO:0042307	positive regulation of protein import into nucleus	0.04144372991574852	0.04144372991574852	+1	PIK3R1,CDH1
GO:0002279	mast cell activation involved in immune response	0.04144372991574852	0.04144372991574852	+1	PIK3CG,KIT
GO:0071276	cellular response to cadmium ion	0.04144372991574852	0.04144372991574852	+1	EGFR,AKT1
GO:0002448	mast cell mediated immunity	0.04144372991574852	0.04144372991574852	+1	PIK3CG,KIT
GO:0043543	protein acylation	0.04144372991574852	0.04144372991574852	+1	BRCA1,EP300,SMAD4,BRCA2,SIN3A
GO:0031114	regulation of microtubule depolymerization	0.04144372991574852	0.04144372991574852	+1	APC,NAV3
GO:0055094	response to lipoprotein particle	0.04144372991574852	0.04144372991574852	+1	AKT1,TLR4
GO:0014002	astrocyte development	0.04144372991574852	0.04144372991574852	+1	NF1,MIR142
GO:0060416	response to growth hormone	0.04144372991574852	0.04144372991574852	+1	PIK3R1,AKT1
GO:0046633	alpha-beta T cell proliferation	0.04144372991574852	0.04144372991574852	+1	TGFBR2,MAPK8IP1
GO:0098815	modulation of excitatory postsynaptic potential	0.04144372991574852	0.04144372991574852	+1	PTEN,LRRK2
GO:0010720	positive regulation of cell development	0.041889697807236864	0.041889697807236864	+1	NOTCH1,CTNNB1,ARHGAP35,EPHA3,EP300,SIN3A,MIR142
GO:0070302	regulation of stress-activated protein kinase signaling cascade	0.041889697807236864	0.041889697807236864	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
GO:0006446	regulation of translational initiation	0.04218214522325056	0.04218214522325056	+1	NPM1,MTOR,EIF4A2
GO:0042098	T cell proliferation	0.0423720527644067	0.0423720527644067	+1	CDKN2A,PIK3CG,TGFBR2,MAPK8IP1
GO:0048588	developmental cell growth	0.0423720527644067	0.0423720527644067	+1	CTNNB1,SOX9,USP9X,SIN3A
GO:0051100	negative regulation of binding	0.04341188395526888	0.04341188395526888	+1	AKT1,LRRK2,TAF1,SIN3A
GO:0010906	regulation of glucose metabolic process	0.04357910595724106	0.04357910595724106	+1	AKT1,EP300,FOXA2
GO:0070167	regulation of biomineral tissue development	0.04357910595724106	0.04357910595724106	+1	NOTCH1,SOX9,ACVR2A
GO:0110149	regulation of biomineralization	0.04357910595724106	0.04357910595724106	+1	NOTCH1,SOX9,ACVR2A
GO:0032607	interferon-alpha production	0.04389413330897666	0.04389413330897666	+1	TLR4,SETD2
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	0.04389413330897666	0.04389413330897666	+1	FBXW7,AKT1
GO:0031018	endocrine pancreas development	0.04389413330897666	0.04389413330897666	+1	AKT1,FOXA2
GO:0044818	mitotic G2/M transition checkpoint	0.04389413330897666	0.04389413330897666	+1	ATM,CDKN1A
GO:0006402	mRNA catabolic process	0.04389413330897666	0.04389413330897666	+1	NPM1,RPL22,AKT1,ATM,PPP2R1A,RPL5,AXIN2
GO:0071402	cellular response to lipoprotein particle stimulus	0.04389413330897666	0.04389413330897666	+1	AKT1,TLR4
GO:0022405	hair cycle process	0.04389413330897666	0.04389413330897666	+1	SOX9,FGFR2
GO:0022404	molting cycle process	0.04389413330897666	0.04389413330897666	+1	SOX9,FGFR2
GO:1904407	positive regulation of nitric oxide metabolic process	0.04389413330897666	0.04389413330897666	+1	AKT1,TLR4
GO:2000352	negative regulation of endothelial cell apoptotic process	0.04389413330897666	0.04389413330897666	+1	GATA3,NFE2L2
GO:0032647	regulation of interferon-alpha production	0.04389413330897666	0.04389413330897666	+1	TLR4,SETD2
GO:0045589	regulation of regulatory T cell differentiation	0.04389413330897666	0.04389413330897666	+1	RUNX1,CBFB
GO:0006261	DNA-dependent DNA replication	0.04407197883683748	0.04407197883683748	+1	ATRX,POLQ,CHEK2,BRCA2
GO:0001894	tissue homeostasis	0.04407197883683748	0.04407197883683748	+1	NF1,NOTCH1,SOX9,TLR4
GO:0005975	carbohydrate metabolic process	0.04450115700811207	0.04450115700811207	+1	TP53,PTEN,AKT1,BRAF,IDH2,EP300,FOXA2,NCOR1
GO:0050776	regulation of immune response	0.044557993391276834	0.044557993391276834	+1	PIK3CA,KRAS,PIK3R1,GATA3,MAP3K1,RUNX1,NRAS,MAP2K4,TLR4,KIT,EP300,CBFB,SIN3A,PTPN11
GO:0055007	cardiac muscle cell differentiation	0.04467367528400762	0.04467367528400762	+1	WT1,PDGFRA,SMAD4
GO:0030282	bone mineralization	0.04467367528400762	0.04467367528400762	+1	FGFR2,FGFR3,ACVR2A
GO:0019217	regulation of fatty acid metabolic process	0.04467367528400762	0.04467367528400762	+1	AKT1,BRCA1,NCOR1
GO:1904951	positive regulation of establishment of protein localization	0.044811253808535206	0.044811253808535206	+1	TP53,PIK3R1,GATA3,FBXW7,CDH1,BAP1,TLR4
GO:0008366	axon ensheathment	0.046078786107344276	0.046078786107344276	+1	PTEN,NF1,PRX
GO:1903363	negative regulation of cellular protein catabolic process	0.046078786107344276	0.046078786107344276	+1	CDKN2A,TAF1,RPL5
GO:0043470	regulation of carbohydrate catabolic process	0.046078786107344276	0.046078786107344276	+1	TP53,EP300,NCOR1
GO:0090288	negative regulation of cellular response to growth factor stimulus	0.046078786107344276	0.046078786107344276	+1	GATA3,NOTCH1,TGFBR2,SMAD2
GO:0042116	macrophage activation	0.046078786107344276	0.046078786107344276	+1	CEBPA,TLR4,MIR142
GO:0007272	ensheathment of neurons	0.046078786107344276	0.046078786107344276	+1	PTEN,NF1,PRX
GO:0006470	protein dephosphorylation	0.046092659689663994	0.046092659689663994	+1	PTEN,STK11,MTOR,PPP2R1A,PTPN11
GO:0098773	skin epidermis development	0.04629657608966154	0.04629657608966154	+1	SOX9,FGFR2
GO:0008156	negative regulation of DNA replication	0.04629657608966154	0.04629657608966154	+1	CHEK2,ATR
GO:0046686	response to cadmium ion	0.04629657608966154	0.04629657608966154	+1	EGFR,AKT1
GO:1904591	positive regulation of protein import	0.04629657608966154	0.04629657608966154	+1	PIK3R1,CDH1
GO:0097028	dendritic cell differentiation	0.04629657608966154	0.04629657608966154	+1	FLT3,TGFBR2
GO:0032728	positive regulation of interferon-beta production	0.04629657608966154	0.04629657608966154	+1	TLR4,PTPN11
GO:0010543	regulation of platelet activation	0.04629657608966154	0.04629657608966154	+1	TLR4,PDGFRA
GO:0001658	branching involved in ureteric bud morphogenesis	0.04629657608966154	0.04629657608966154	+1	SOX9,WT1
GO:0021761	limbic system development	0.04629657608966154	0.04629657608966154	+1	PTEN,FGFR2
GO:0051704	multi-organism process	0.04678900184431825	0.04678900184431825	+1	TP53,PTEN,KRAS,GATA3,CTNNB1,MAP3K1,CDH1,NRAS,RPL22,PIK3CG,SOX9,WT1,TLR4,KIT,SETD2,EP300,USP9X,SIN3A,PTPN11,ACVR1B,RPL5,MIR142,PCBP1
GO:0002429	immune response-activating cell surface receptor signaling pathway	0.04721124735855788	0.04721124735855788	+1	PIK3CA,KRAS,PIK3R1,GATA3,RUNX1,NRAS,EP300,CBFB
GO:0006476	protein deacetylation	0.04732153726529755	0.04732153726529755	+1	EP300,SIN3A,TBL1XR1
GO:0042542	response to hydrogen peroxide	0.04732153726529755	0.04732153726529755	+1	NFE2L2,HGF,LRRK2
GO:0006886	intracellular protein transport	0.047446891305028896	0.047446891305028896	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,NPM1,IDH1,RPL22,AKT1,U2AF1,LRRK2,SETD2,USP9X,RPL5
GO:0046677	response to antibiotic	0.04777325904969893	0.04777325904969893	+1	TP53,NFE2L2,HGF,LRRK2
GO:0031349	positive regulation of defense response	0.04820709480682126	0.04820709480682126	+1	KRAS,MAP3K1,NRAS,CEBPA,TLR4,EP300,SIN3A,MIR142
GO:0002318	myeloid progenitor cell differentiation	0.04834211679771756	0.04834211679771756	+1	FLT3
GO:0097681	double-strand break repair via alternative nonhomologous end joining	0.04834211679771756	0.04834211679771756	+1	POLQ
GO:0051136	regulation of NK T cell differentiation	0.04834211679771756	0.04834211679771756	+1	TGFBR2
GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	0.04834211679771756	0.04834211679771756	+1	FOXA2
GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose	0.04834211679771756	0.04834211679771756	+1	FOXA2
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	0.04834211679771756	0.04834211679771756	+1	FGFR2
GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	0.04834211679771756	0.04834211679771756	+1	TAF1
GO:2001205	negative regulation of osteoclast development	0.04834211679771756	0.04834211679771756	+1	FBXW7
GO:0060742	epithelial cell differentiation involved in prostate gland development	0.04834211679771756	0.04834211679771756	+1	FGFR2
GO:0002513	tolerance induction to self antigen	0.04834211679771756	0.04834211679771756	+1	TGFBR2
GO:0002514	B cell tolerance induction	0.04834211679771756	0.04834211679771756	+1	TGFBR2
GO:0035986	senescence-associated heterochromatin focus assembly	0.04834211679771756	0.04834211679771756	+1	CDKN2A
GO:0010750	positive regulation of nitric oxide mediated signal transduction	0.04834211679771756	0.04834211679771756	+1	EGFR
GO:0045448	mitotic cell cycle, embryonic	0.04834211679771756	0.04834211679771756	+1	CTNNB1
GO:1905289	regulation of CAMKK-AMPK signaling cascade	0.04834211679771756	0.04834211679771756	+1	LRRK2
GO:0097252	oligodendrocyte apoptotic process	0.04834211679771756	0.04834211679771756	+1	TP53
GO:0002331	pre-B cell allelic exclusion	0.04834211679771756	0.04834211679771756	+1	ATM
GO:0002262	myeloid cell homeostasis	0.04834211679771756	0.04834211679771756	+1	KIT,ACVR1B,ACVR2A
GO:0031134	sister chromatid biorientation	0.04834211679771756	0.04834211679771756	+1	RB1
GO:0046532	regulation of photoreceptor cell differentiation	0.04834211679771756	0.04834211679771756	+1	SOX9
GO:1904209	positive regulation of chemokine (C-C motif) ligand 2 secretion	0.04834211679771756	0.04834211679771756	+1	TLR4
GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	0.04834211679771756	0.04834211679771756	+1	CTNNB1
GO:0030997	regulation of centriole-centriole cohesion	0.04834211679771756	0.04834211679771756	+1	CTNNB1
GO:0009794	regulation of mitotic cell cycle, embryonic	0.04834211679771756	0.04834211679771756	+1	CTNNB1
GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process	0.04834211679771756	0.04834211679771756	+1	CTNNB1
GO:0035564	regulation of kidney size	0.04834211679771756	0.04834211679771756	+1	LRRK2
GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	0.04834211679771756	0.04834211679771756	+1	PTEN
GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	0.04834211679771756	0.04834211679771756	+1	TLR4
GO:1903971	positive regulation of response to macrophage colony-stimulating factor	0.04834211679771756	0.04834211679771756	+1	TLR4
GO:0014034	neural crest cell fate commitment	0.04834211679771756	0.04834211679771756	+1	SOX9
GO:0001302	replicative cell aging	0.04834211679771756	0.04834211679771756	+1	CHEK2
GO:1904760	regulation of myofibroblast differentiation	0.04834211679771756	0.04834211679771756	+1	RB1
GO:0014041	regulation of neuron maturation	0.04834211679771756	0.04834211679771756	+1	LRRK2
GO:0045066	regulatory T cell differentiation	0.04834211679771756	0.04834211679771756	+1	RUNX1,CBFB
GO:0060374	mast cell differentiation	0.04834211679771756	0.04834211679771756	+1	KIT
GO:1903691	positive regulation of wound healing, spreading of epidermal cells	0.04834211679771756	0.04834211679771756	+1	MTOR
GO:0000733	DNA strand renaturation	0.04834211679771756	0.04834211679771756	+1	TP53
GO:1901186	positive regulation of ERBB signaling pathway	0.04834211679771756	0.04834211679771756	+1	FBXW7,AKT1
GO:0061325	cell proliferation involved in outflow tract morphogenesis	0.04834211679771756	0.04834211679771756	+1	CTNNB1
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	0.04834211679771756	0.04834211679771756	+1	NFE2L2,AKT1,LRRK2
GO:0060214	endocardium formation	0.04834211679771756	0.04834211679771756	+1	SOX17
GO:0031999	negative regulation of fatty acid beta-oxidation	0.04834211679771756	0.04834211679771756	+1	AKT1
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	0.04834211679771756	0.04834211679771756	+1	LRRK2
GO:0048861	leukemia inhibitory factor signaling pathway	0.04834211679771756	0.04834211679771756	+1	LIFR
GO:0072277	metanephric glomerular capillary formation	0.04834211679771756	0.04834211679771756	+1	PDGFRA
GO:0048871	multicellular organismal homeostasis	0.04834211679771756	0.04834211679771756	+1	APC,NF1,RB1,NOTCH1,STK11,SOX9,TLR4
GO:2000111	positive regulation of macrophage apoptotic process	0.04834211679771756	0.04834211679771756	+1	CDKN2A
GO:0072276	metanephric glomerulus vasculature morphogenesis	0.04834211679771756	0.04834211679771756	+1	PDGFRA
GO:0072275	metanephric glomerulus morphogenesis	0.04834211679771756	0.04834211679771756	+1	PDGFRA
GO:0050703	interleukin-1 alpha secretion	0.04834211679771756	0.04834211679771756	+1	MIR142
GO:1902948	negative regulation of tau-protein kinase activity	0.04834211679771756	0.04834211679771756	+1	RB1
GO:0072262	metanephric glomerular mesangial cell proliferation involved in metanephros development	0.04834211679771756	0.04834211679771756	+1	WT1
GO:0036216	cellular response to stem cell factor stimulus	0.04834211679771756	0.04834211679771756	+1	KIT
GO:0036215	response to stem cell factor	0.04834211679771756	0.04834211679771756	+1	KIT
GO:1902339	positive regulation of apoptotic process involved in morphogenesis	0.04834211679771756	0.04834211679771756	+1	NOTCH1
GO:0045726	positive regulation of integrin biosynthetic process	0.04834211679771756	0.04834211679771756	+1	AR
GO:0072179	nephric duct formation	0.04834211679771756	0.04834211679771756	+1	GATA3
GO:0034183	negative regulation of maintenance of mitotic sister chromatid cohesion	0.04834211679771756	0.04834211679771756	+1	ATRX
GO:0019857	5-methylcytosine metabolic process	0.04834211679771756	0.04834211679771756	+1	TET2
GO:0032497	detection of lipopolysaccharide	0.04834211679771756	0.04834211679771756	+1	TLR4
GO:2000638	regulation of SREBP signaling pathway	0.04834211679771756	0.04834211679771756	+1	FBXW7
GO:0042593	glucose homeostasis	0.04834211679771756	0.04834211679771756	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:0038109	Kit signaling pathway	0.04834211679771756	0.04834211679771756	+1	KIT
GO:0032707	negative regulation of interleukin-23 production	0.04834211679771756	0.04834211679771756	+1	TLR4
GO:0038162	erythropoietin-mediated signaling pathway	0.04834211679771756	0.04834211679771756	+1	KIT
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	0.04834211679771756	0.04834211679771756	+1	PDGFRA
GO:2000468	regulation of peroxidase activity	0.04834211679771756	0.04834211679771756	+1	LRRK2
GO:0072717	cellular response to actinomycin D	0.04834211679771756	0.04834211679771756	+1	TP53
GO:1902822	regulation of late endosome to lysosome transport	0.04834211679771756	0.04834211679771756	+1	LRRK2
GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	0.04834211679771756	0.04834211679771756	+1	EP300
GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway	0.04834211679771756	0.04834211679771756	+1	PDGFRA
GO:2000611	positive regulation of thyroid hormone generation	0.04834211679771756	0.04834211679771756	+1	GATA3
GO:0072434	signal transduction involved in mitotic G2 DNA damage checkpoint	0.04834211679771756	0.04834211679771756	+1	ATM
GO:0032808	lacrimal gland development	0.04834211679771756	0.04834211679771756	+1	FGFR2
GO:0006924	activation-induced cell death of T cells	0.04834211679771756	0.04834211679771756	+1	AKT1
GO:0036369	transcription factor catabolic process	0.04834211679771756	0.04834211679771756	+1	TAF1
GO:2000172	regulation of branching morphogenesis of a nerve	0.04834211679771756	0.04834211679771756	+1	LRRK2
GO:1902730	positive regulation of proteoglycan biosynthetic process	0.04834211679771756	0.04834211679771756	+1	CTNNB1
GO:0045967	negative regulation of growth rate	0.04834211679771756	0.04834211679771756	+1	NOTCH1
GO:0046016	positive regulation of transcription by glucose	0.04834211679771756	0.04834211679771756	+1	FOXA2
GO:1905636	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding	0.04834211679771756	0.04834211679771756	+1	EP300
GO:0071839	apoptotic process in bone marrow cell	0.04834211679771756	0.04834211679771756	+1	FGFR2
GO:0003192	mitral valve formation	0.04834211679771756	0.04834211679771756	+1	NOTCH1
GO:0043456	regulation of pentose-phosphate shunt	0.04834211679771756	0.04834211679771756	+1	TP53
GO:0097155	fasciculation of sensory neuron axon	0.04834211679771756	0.04834211679771756	+1	EPHA3
GO:0046533	negative regulation of photoreceptor cell differentiation	0.04834211679771756	0.04834211679771756	+1	SOX9
GO:0071865	regulation of apoptotic process in bone marrow cell	0.04834211679771756	0.04834211679771756	+1	FGFR2
GO:0033500	carbohydrate homeostasis	0.04834211679771756	0.04834211679771756	+1	PIK3R1,STK11,CEBPA,FOXA2
GO:0060913	cardiac cell fate determination	0.04834211679771756	0.04834211679771756	+1	SOX17
GO:2000825	positive regulation of androgen receptor activity	0.04834211679771756	0.04834211679771756	+1	TAF1
GO:0061209	cell proliferation involved in mesonephros development	0.04834211679771756	0.04834211679771756	+1	GATA3
GO:1905897	regulation of response to endoplasmic reticulum stress	0.04834211679771756	0.04834211679771756	+1	PIK3R1,NFE2L2,LRRK2
GO:2000974	negative regulation of pro-B cell differentiation	0.04834211679771756	0.04834211679771756	+1	NOTCH1
GO:0003273	cell migration involved in endocardial cushion formation	0.04834211679771756	0.04834211679771756	+1	NOTCH1
GO:2000807	regulation of synaptic vesicle clustering	0.04834211679771756	0.04834211679771756	+1	PTEN
GO:1903335	regulation of vacuolar transport	0.04834211679771756	0.04834211679771756	+1	LRRK2
GO:0036023	embryonic skeletal limb joint morphogenesis	0.04834211679771756	0.04834211679771756	+1	CTNNB1
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	0.04834211679771756	0.04834211679771756	+1	RB1
GO:0032204	regulation of telomere maintenance	0.04834211679771756	0.04834211679771756	+1	ATM,ATRX,ATR
GO:0007411	axon guidance	0.04834211679771756	0.04834211679771756	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,PTPN11
GO:1905940	negative regulation of gonad development	0.04834211679771756	0.04834211679771756	+1	WT1
GO:0032354	response to follicle-stimulating hormone	0.04834211679771756	0.04834211679771756	+1	NOTCH1
GO:0051443	positive regulation of ubiquitin-protein transferase activity	0.04834211679771756	0.04834211679771756	+1	PTEN,FBXW7
GO:0070662	mast cell proliferation	0.04834211679771756	0.04834211679771756	+1	KIT
GO:0006211	5-methylcytosine catabolic process	0.04834211679771756	0.04834211679771756	+1	TET2
GO:0007406	negative regulation of neuroblast proliferation	0.04834211679771756	0.04834211679771756	+1	NF1
GO:1990428	miRNA transport	0.04834211679771756	0.04834211679771756	+1	TGFBR2
GO:0061218	negative regulation of mesonephros development	0.04834211679771756	0.04834211679771756	+1	GATA3
GO:0034092	negative regulation of maintenance of sister chromatid cohesion	0.04834211679771756	0.04834211679771756	+1	ATRX
GO:0036022	limb joint morphogenesis	0.04834211679771756	0.04834211679771756	+1	CTNNB1
GO:2000609	regulation of thyroid hormone generation	0.04834211679771756	0.04834211679771756	+1	GATA3
GO:1905457	negative regulation of lymphoid progenitor cell differentiation	0.04834211679771756	0.04834211679771756	+1	NOTCH1
GO:0046700	heterocycle catabolic process	0.0484389673661337	0.0484389673661337	+1	CDKN2A,NPM1,RPL22,AKT1,ATM,TET2,PPP2R1A,RPL5,AXIN2
GO:0097485	neuron projection guidance	0.04889170361780083	0.04889170361780083	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,PTPN11
GO:1903955	positive regulation of protein targeting to mitochondrion	0.048910587070173026	0.048910587070173026	+1	FBXW7,BAP1
GO:0045616	regulation of keratinocyte differentiation	0.048910587070173026	0.048910587070173026	+1	RUNX1,CBFB
GO:0046825	regulation of protein export from nucleus	0.048910587070173026	0.048910587070173026	+1	TP53,SETD2
GO:0048009	insulin-like growth factor receptor signaling pathway	0.048910587070173026	0.048910587070173026	+1	PIK3R1,AKT1
GO:0060969	negative regulation of gene silencing	0.048910587070173026	0.048910587070173026	+1	HIST1H1C,NCOR1
GO:0051984	positive regulation of chromosome segregation	0.048910587070173026	0.048910587070173026	+1	RB1,RAD21
GO:0035767	endothelial cell chemotaxis	0.048910587070173026	0.048910587070173026	+1	NOTCH1,EGR3
GO:0000186	activation of MAPKK activity	0.048910587070173026	0.048910587070173026	+1	BRAF,LRRK2
GO:0061001	regulation of dendritic spine morphogenesis	0.048910587070173026	0.048910587070173026	+1	PTEN,LRRK2
GO:0006298	mismatch repair	0.048910587070173026	0.048910587070173026	+1	SETD2,AXIN2
GO:0001776	leukocyte homeostasis	0.048910587070173026	0.048910587070173026	+1	FLT3,AKT1
GO:0046636	negative regulation of alpha-beta T cell activation	0.048910587070173026	0.048910587070173026	+1	RUNX1,CBFB
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	0.048910587070173026	0.048910587070173026	+1	ATM,ATR
GO:0044270	cellular nitrogen compound catabolic process	0.04908067404463115	0.04908067404463115	+1	CDKN2A,NPM1,RPL22,AKT1,ATM,TET2,PPP2R1A,RPL5,AXIN2
REAC:R-HSA-5663202	Diseases of signal transduction	3.046539320643706e-15	3.046539320643706e-15	+1	PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,NOTCH1,CTNNB1,NRAS,AKT1,BRAF,CDKN1B,HGF,MTOR,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,PPP2R1A,PTPN11,TBL1XR1,NCOR1,SMAD2
REAC:R-HSA-1643685	Disease	3.5589682475976703e-12	3.5589682475976703e-12	+1	PIK3CA,PTEN,APC,KRAS,EGFR,NF1,PIK3R1,CDKN2A,NOTCH1,CTNNB1,CDH1,NPM1,NRAS,IDH1,MAP2K4,RPL22,AKT1,BRAF,CDKN1B,HGF,MTOR,TLR4,KIT,PDGFRA,EP300,FGFR2,SMAD4,FGFR3,TGFBR2,CDKN1A,TAF1,PPP2R1A,SIN3A,PTPN11,TBL1XR1,NCOR1,RPL5,SMAD2,ERCC2
REAC:R-HSA-212436	Generic Transcription Pathway	3.5589682475976703e-12	3.5589682475976703e-12	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,NPM1,RUNX1,STK11,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-74160	Gene expression (Transcription)	3.5589682475976703e-12	3.5589682475976703e-12	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,DNMT3A,NPM1,RUNX1,STK11,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,U2AF1,TET2,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,SF3B1,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-73857	RNA Polymerase II Transcription	1.190505513247217e-11	1.190505513247217e-11	+1	TP53,PTEN,KRAS,ARID1A,PBRM1,EGFR,CDKN2A,GATA3,RB1,NOTCH1,CTNNB1,NPM1,RUNX1,STK11,AKT1,AR,SOX9,ATM,CDKN1B,MTOR,U2AF1,BRCA1,CHEK2,KIT,EP300,CCND1,SMAD4,USP9X,CDKN1A,TAF1,PPP2R1A,CBFB,ATR,SIN3A,HIST1H2BD,CDK12,PTPN11,TBL1XR1,LIFR,NCOR1,SMAD2,ERCC2,EZH2
REAC:R-HSA-8939211	ESR-mediated signaling	3.7867327569843966e-9	3.7867327569843966e-9	+1	PIK3CA,EGFR,PIK3R1,GATA3,RUNX1,NRAS,AKT1,STAG2,CDKN1B,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-9006931	Signaling by Nuclear Receptors	4.6751546159412686e-9	4.6751546159412686e-9	+1	PIK3CA,EGFR,PIK3R1,GATA3,RUNX1,NRAS,AKT1,STAG2,CDKN1B,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,TBL1XR1,SMC3,NCOR1,RAD21
REAC:R-HSA-2219528	PI3K/AKT Signaling in Cancer	4.900588896097685e-9	4.900588896097685e-9	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PTPN11
REAC:R-HSA-8878159	Transcriptional regulation by RUNX3	1.3859775042836187e-7	1.3859775042836187e-7	+1	TP53,KRAS,CDKN2A,NOTCH1,CTNNB1,RUNX1,EP300,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-1257604	PIP3 activates AKT signaling	1.6100375108439852e-7	1.6100375108439852e-7	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PPP2R1A,PTPN11,MECOM,EZH2
REAC:R-HSA-8951936	RUNX3 regulates p14-ARF	3.245218320478665e-7	3.245218320478665e-7	+1	KRAS,RUNX1,EP300,CCND1,CBFB
REAC:R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	6.2335554053014e-7	6.2335554053014e-7	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-3700989	Transcriptional Regulation by TP53	6.516426234607394e-7	6.516426234607394e-7	+1	TP53,PTEN,CDKN2A,NPM1,STK11,AKT1,ATM,CDKN1B,MTOR,BRCA1,CHEK2,EP300,CDKN1A,TAF1,PPP2R1A,ATR,CDK12,ERCC2
REAC:R-HSA-2990846	SUMOylation	8.127368518991549e-7	8.127368518991549e-7	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
REAC:R-HSA-162582	Signal Transduction	8.453449453269387e-7	8.453449453269387e-7	+1	TP53,PIK3CA,PTEN,APC,EGFR,NF1,PIK3R1,GATA3,NOTCH1,CTNNB1,FLT3,CDH1,ARHGAP35,RUNX1,NRAS,STK11,AKT1,STAG2,BRAF,AR,PIK3CG,SOX9,CDKN1B,HGF,MTOR,ELF3,LRRK2,FOXA1,KIT,PDGFRA,EP300,CCND1,SMAD4,USP9X,TGFBR2,SOX17,CDKN1A,PPP2R1A,CBFB,HIST1H2BD,SMC1A,PTPN11,ACVR1B,TBL1XR1,ACVR2A,MECOM,SMC3,NCOR1,SMAD2,SPOP,AXIN2,RAD21,EZH2
REAC:R-HSA-9006925	Intracellular signaling by second messengers	8.453449453269387e-7	8.453449453269387e-7	+1	TP53,PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PPP2R1A,PTPN11,MECOM,EZH2
REAC:R-HSA-5688426	Deubiquitination	0.000001237504414926642	0.000001237504414926642	+1	TP53,PTEN,APC,GATA3,KEAP1,BAP1,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,HIST1H2BD,SMAD2,AXIN2
REAC:R-HSA-199418	Negative regulation of the PI3K/AKT network	0.000001256214806249967	0.000001256214806249967	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-6804757	Regulation of TP53 Degradation	0.0000018328876465898214	0.0000018328876465898214	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-5633007	Regulation of TP53 Activity	0.0000018328876465898214	0.0000018328876465898214	+1	TP53,CDKN2A,STK11,AKT1,ATM,MTOR,BRCA1,CHEK2,EP300,TAF1,PPP2R1A,ATR
REAC:R-HSA-4839726	Chromatin organization	0.0000020207386531097152	0.0000020207386531097152	+1	ARID1A,PBRM1,DNMT3A,KDM6A,KDM5C,ARID5B,SETD2,EP300,CCND1,HIST1H2BD,NSD1,TBL1XR1,MECOM,NCOR1,EZH2
REAC:R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.0000020207386531097152	0.0000020207386531097152	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
REAC:R-HSA-3247509	Chromatin modifying enzymes	0.0000020207386531097152	0.0000020207386531097152	+1	ARID1A,PBRM1,DNMT3A,KDM6A,KDM5C,ARID5B,SETD2,EP300,CCND1,HIST1H2BD,NSD1,TBL1XR1,MECOM,NCOR1,EZH2
REAC:R-HSA-1640170	Cell Cycle	0.000004353361811688727	0.000004353361811688727	+1	TP53,CDKN2A,RB1,NPM1,AKT1,STAG2,AJUBA,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,BRCA2,CDKN1A,PPP2R1A,ATR,HIST1H2BD,SMC1A,SMC3,RAD21,CDKN2C
REAC:R-HSA-69236	G1 Phase	0.000005147863815510576	0.000005147863815510576	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-69231	Cyclin D associated events in G1	0.000005147863815510576	0.000005147863815510576	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.000005576705413278559	0.000005576705413278559	+1	PIK3CA,EGFR,PIK3R1,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-9018519	Estrogen-dependent gene expression	0.000005724454417701983	0.000005724454417701983	+1	GATA3,RUNX1,STAG2,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-9614085	FOXO-mediated transcription	0.000006244744336851412	0.000006244744336851412	+1	STK11,AKT1,CDKN1B,EP300,SMAD4,CDKN1A,SIN3A,SMAD2
REAC:R-HSA-1266738	Developmental Biology	0.000007042469560366751	0.000007042469560366751	+1	PIK3CA,EGFR,PIK3R1,NOTCH1,CTNNB1,ARHGAP35,CTCF,RUNX1,NRAS,RPL22,CEBPA,KDM6A,EPHA3,AKT1,AJUBA,EP300,SMAD4,FOXA2,CDKN1A,CBFB,HIST1H2BD,PTPN11,ACVR1B,TBL1XR1,ACVR2A,NCOR1,RPL5,SMAD2,EZH2
REAC:R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	0.000013674021451666916	0.000013674021451666916	+1	EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
REAC:R-HSA-8848021	Signaling by PTK6	0.000013674021451666916	0.000013674021451666916	+1	EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
REAC:R-HSA-5654741	Signaling by FGFR3	0.000013674021451666916	0.000013674021451666916	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-8853334	Signaling by FGFR3 fusions in cancer	0.000013943706363213452	0.000013943706363213452	+1	PIK3CA,PIK3R1,NRAS,FGFR3
REAC:R-HSA-5654743	Signaling by FGFR4	0.000022285785357743073	0.000022285785357743073	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-2470946	Cohesin Loading onto Chromatin	0.000038919073229366816	0.000038919073229366816	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-1500620	Meiosis	0.00004223699448538445	0.00004223699448538445	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-8878166	Transcriptional regulation by RUNX2	0.000044165440573561284	0.000044165440573561284	+1	RB1,RUNX1,AKT1,AR,SOX9,CCND1,SMAD4,CDKN1A,CBFB
REAC:R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.000045035115719717295	0.000045035115719717295	+1	PIK3CA,EGFR,PIK3R1,HGF,KIT,PDGFRA,PTPN11
REAC:R-HSA-5654736	Signaling by FGFR1	0.000051529068676247	0.000051529068676247	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-2559583	Cellular Senescence	0.00005162305236324684	0.00005162305236324684	+1	TP53,CDKN2A,RB1,MAP2K4,ATM,CDKN1B,HIST1H1C,CDKN1A,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.000052030117961648216	0.000052030117961648216	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-2262752	Cellular responses to stress	0.00005746966076016828	0.00005746966076016828	+1	TP53,VHL,CDKN2A,RB1,MAP2K4,AR,AJUBA,ATM,CDKN1B,MTOR,HIST1H1C,EP300,CDKN1A,ATR,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-6802953	RAS signaling downstream of NF1 loss-of-function variants	0.00006671955150861202	0.00006671955150861202	+1	KRAS,NF1,NRAS
REAC:R-HSA-186763	Downstream signal transduction	0.00007935787117097355	0.00007935787117097355	+1	PIK3CA,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-8953897	Cellular responses to external stimuli	0.00007935787117097355	0.00007935787117097355	+1	TP53,VHL,CDKN2A,RB1,MAP2K4,AR,AJUBA,ATM,CDKN1B,MTOR,HIST1H1C,EP300,CDKN1A,ATR,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.00009145707480724542	0.00009145707480724542	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.00009145707480724542	0.00009145707480724542	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-1502540	Signaling by Activin	0.00009145707480724542	0.00009145707480724542	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-9607240	FLT3 Signaling	0.00009145707480724542	0.00009145707480724542	+1	PIK3CA,EGFR,NF1,PIK3R1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-68884	Mitotic Telophase/Cytokinesis	0.00009145707480724542	0.00009145707480724542	+1	STAG2,SMC1A,SMC3,RAD21
REAC:R-HSA-9009391	Extra-nuclear estrogen signaling	0.00010254168825724107	0.00010254168825724107	+1	PIK3CA,EGFR,PIK3R1,NRAS,AKT1,CDKN1B,CCND1
REAC:R-HSA-8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	0.00013249453418268827	0.00013249453418268827	+1	RUNX1,CBFB,LIFR
REAC:R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	0.00013249453418268827	0.00013249453418268827	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-8851907	MET activates PI3K/AKT signaling	0.00013249453418268827	0.00013249453418268827	+1	PIK3CA,PIK3R1,HGF
REAC:R-HSA-1221632	Meiotic synapsis	0.0001361418075267228	0.0001361418075267228	+1	STAG2,BRCA1,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-1474165	Reproduction	0.00014362173615596293	0.00014362173615596293	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
REAC:R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.00016955423112644964	0.00016955423112644964	+1	TP53,RB1,ATM,CDKN1B,HIST1H1C,CDKN1A,HIST1H2BD
REAC:R-HSA-180292	GAB1 signalosome	0.00019348370885804915	0.00019348370885804915	+1	PIK3CA,EGFR,PIK3R1,PTPN11
REAC:R-HSA-210993	Tie2 Signaling	0.00019348370885804915	0.00019348370885804915	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-157118	Signaling by NOTCH	0.00020179984582216823	0.00020179984582216823	+1	TP53,EGFR,NOTCH1,RUNX1,AKT1,ELF3,EP300,CCND1,HIST1H2BD,TBL1XR1,NCOR1
REAC:R-HSA-9617828	FOXO-mediated transcription of cell cycle genes	0.00021525456698816484	0.00021525456698816484	+1	CDKN1B,SMAD4,CDKN1A,SMAD2
REAC:R-HSA-8941855	RUNX3 regulates CDKN1A transcription	0.00021525456698816484	0.00021525456698816484	+1	TP53,SMAD4,CDKN1A
REAC:R-HSA-8878171	Transcriptional regulation by RUNX1	0.00021525456698816484	0.00021525456698816484	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,CCND1,CBFB,SIN3A,HIST1H2BD,PTPN11,LIFR
REAC:R-HSA-5655332	Signaling by FGFR3 in disease	0.00021525456698816484	0.00021525456698816484	+1	PIK3CA,PIK3R1,NRAS,FGFR3
REAC:R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	0.00021525456698816484	0.00021525456698816484	+1	PIK3CA,PIK3R1,NRAS,FGFR3
REAC:R-HSA-8934593	Regulation of RUNX1 Expression and Activity	0.00021525456698816484	0.00021525456698816484	+1	RUNX1,CCND1,CBFB,PTPN11
REAC:R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.00021525456698816484	0.00021525456698816484	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.00021525456698816484	0.00021525456698816484	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.00021525456698816484	0.00021525456698816484	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	0.0002688603364388914	0.0002688603364388914	+1	ARID1A,PBRM1,RUNX1,EP300,CBFB
REAC:R-HSA-5654708	Downstream signaling of activated FGFR3	0.0002688603364388914	0.0002688603364388914	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-69242	S Phase	0.00029053322026938096	0.00029053322026938096	+1	RB1,AKT1,STAG2,CDKN1B,CCND1,CDKN1A,SMC1A,SMC3,RAD21
REAC:R-HSA-6804760	Regulation of TP53 Activity through Methylation	0.0003266828047844741	0.0003266828047844741	+1	TP53,ATM,CHEK2,EP300
REAC:R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.0003287637091325563	0.0003287637091325563	+1	TP53,STK11,ATM,BRCA1,CHEK2,TAF1,ATR
REAC:R-HSA-1433557	Signaling by SCF-KIT	0.0003296070367971515	0.0003296070367971515	+1	PIK3CA,PIK3R1,NRAS,KIT,PTPN11
REAC:R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.0003296070367971515	0.0003296070367971515	+1	EGFR,NPM1,KIT,EP300,CDKN1A
REAC:R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.0003315104249662908	0.0003315104249662908	+1	PIK3CA,EGFR,PIK3R1,CTNNB1,FLT3,NRAS,AKT1,BRAF,HGF,MTOR,KIT,PDGFRA,PPP2R1A,PTPN11,NCOR1
REAC:R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.00033485636146910293	0.00033485636146910293	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-5693532	DNA Double-Strand Break Repair	0.00033774548067164824	0.00033774548067164824	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-112399	IRS-mediated signalling	0.00035664976163357875	0.00035664976163357875	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-1181150	Signaling by NODAL	0.0003657680258253332	0.0003657680258253332	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
REAC:R-HSA-5654738	Signaling by FGFR2	0.00037334995834480687	0.00037334995834480687	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.00037334995834480687	0.00037334995834480687	+1	TP53,ATM,BRCA1,ATR,CDK12,ERCC2
REAC:R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	0.0003980011953914482	0.0003980011953914482	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-69563	p53-Dependent G1 DNA Damage Response	0.0003980011953914482	0.0003980011953914482	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-69278	Cell Cycle, Mitotic	0.000419680053708773	0.000419680053708773	+1	TP53,CDKN2A,RB1,AKT1,STAG2,AJUBA,CDKN1B,EP300,CCND1,CDKN1A,PPP2R1A,HIST1H2BD,SMC1A,SMC3,RAD21,CDKN2C
REAC:R-HSA-388841	Costimulation by the CD28 family	0.000419680053708773	0.000419680053708773	+1	PIK3CA,PIK3R1,AKT1,MTOR,PPP2R1A,PTPN11
REAC:R-HSA-9006115	Signaling by NTRK2 (TRKB)	0.000419680053708773	0.000419680053708773	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-69615	G1/S DNA Damage Checkpoints	0.0004510171444537777	0.0004510171444537777	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
REAC:R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.0004583231496457963	0.0004583231496457963	+1	APC,CTNNB1,AKT1,SOX9,SOX17
REAC:R-HSA-9006936	Signaling by TGF-beta family members	0.0004596266297491607	0.0004596266297491607	+1	SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,NCOR1,SMAD2
REAC:R-HSA-5654716	Downstream signaling of activated FGFR4	0.00047458920565014484	0.00047458920565014484	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.00047458920565014484	0.00047458920565014484	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-2428924	IGF1R signaling cascade	0.00048784627144419167	0.00048784627144419167	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-2428928	IRS-related events triggered by IGF1R	0.00048784627144419167	0.00048784627144419167	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-5689880	Ub-specific processing proteases	0.0004898822249973341	0.0004898822249973341	+1	TP53,PTEN,GATA3,KEAP1,AR,SMAD4,USP9X,HIST1H2BD,SMAD2,AXIN2
REAC:R-HSA-1643713	Signaling by EGFR in Cancer	0.0005203993098613156	0.0005203993098613156	+1	PIK3CA,EGFR,PIK3R1,NRAS
REAC:R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.0005203993098613156	0.0005203993098613156	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-9006335	Signaling by Erythropoietin	0.0005203993098613156	0.0005203993098613156	+1	PIK3CA,PIK3R1,NRAS,PIK3CG
REAC:R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.0005203993098613156	0.0005203993098613156	+1	SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-5654687	Downstream signaling of activated FGFR1	0.0005203993098613156	0.0005203993098613156	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-5654696	Downstream signaling of activated FGFR2	0.0005203993098613156	0.0005203993098613156	+1	PIK3CA,PIK3R1,NRAS,PTPN11
REAC:R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	0.0005399426952911962	0.0005399426952911962	+1	CDKN2A,STAG2,BRCA1,SMC1A,SMC3,RAD21
REAC:R-HSA-74751	Insulin receptor signalling cascade	0.0005574673909247656	0.0005574673909247656	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-5655291	Signaling by FGFR4 in disease	0.0005613140553775664	0.0005613140553775664	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	0.00059665901139219	0.00059665901139219	+1	EGFR,AKT1,CDKN1B,CCND1
REAC:R-HSA-1227986	Signaling by ERBB2	0.0006034159204791173	0.0006034159204791173	+1	PIK3CA,EGFR,PIK3R1,NRAS,AKT1
REAC:R-HSA-1912422	Pre-NOTCH Expression and Processing	0.0006625173485568111	0.0006625173485568111	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REAC:R-HSA-177929	Signaling by EGFR	0.0006625173485568111	0.0006625173485568111	+1	PIK3CA,EGFR,PIK3R1,NRAS,PTPN11
REAC:R-HSA-212165	Epigenetic regulation of gene expression	0.0006625173485568111	0.0006625173485568111	+1	DNMT3A,TET2,EP300,SF3B1,SIN3A,HIST1H2BD,ERCC2,EZH2
REAC:R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.0006738948115413196	0.0006738948115413196	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-190236	Signaling by FGFR	0.0006738948115413196	0.0006738948115413196	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.0006752784631111734	0.0006752784631111734	+1	TP53,PIK3R1,GATA3,AKT1,HGF,CCND1,CDKN1A
REAC:R-HSA-453279	Mitotic G1 phase and G1/S transition	0.0006752784631111734	0.0006752784631111734	+1	CDKN2A,RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REAC:R-HSA-5693606	DNA Double Strand Break Response	0.000701495908140538	0.000701495908140538	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
REAC:R-HSA-5684996	MAPK1/MAPK3 signaling	0.000701495908140538	0.000701495908140538	+1	EGFR,NF1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.0007444488562578349	0.0007444488562578349	+1	AKT1,CDKN1B,MTOR,CDKN1A
REAC:R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.0007444488562578349	0.0007444488562578349	+1	TP53,NPM1,CDKN1B,EP300,CDKN1A
REAC:R-HSA-1280215	Cytokine Signaling in Immune system	0.0008548959142256321	0.0008548959142256321	+1	TP53,PIK3CA,EGFR,NF1,PIK3R1,GATA3,FLT3,NRAS,MAP2K4,AKT1,BRAF,HGF,KIT,PDGFRA,CCND1,CDKN1A,PPP2R1A,EIF4A2,PTPN11,LIFR
REAC:R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	0.0009444958229894309	0.0009444958229894309	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9005895	Pervasive developmental disorders	0.0009444958229894309	0.0009444958229894309	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-186797	Signaling by PDGF	0.0011220804931949982	0.0011220804931949982	+1	PIK3CA,PIK3R1,NRAS,PDGFRA,PTPN11
REAC:R-HSA-1236394	Signaling by ERBB4	0.0011220804931949982	0.0011220804931949982	+1	PIK3CA,EGFR,PIK3R1,NRAS,NCOR1
REAC:R-HSA-5619507	Activation of HOX genes during differentiation	0.0011220804931949982	0.0011220804931949982	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.0011220804931949982	0.0011220804931949982	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
REAC:R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.0012012087613038724	0.0012012087613038724	+1	PIK3CA,PIK3R1,PIK3CG
REAC:R-HSA-8941326	RUNX2 regulates bone development	0.0012300021568658918	0.0012300021568658918	+1	RB1,AR,SMAD4,CBFB
REAC:R-HSA-389356	CD28 co-stimulation	0.0013908636946081867	0.0013908636946081867	+1	PIK3CA,PIK3R1,AKT1,MTOR
REAC:R-HSA-9616222	Transcriptional regulation of granulopoiesis	0.001396352086487522	0.001396352086487522	+1	RUNX1,CEBPA,EP300,CDKN1A,CBFB,HIST1H2BD
REAC:R-HSA-1226099	Signaling by FGFR in disease	0.001396352086487522	0.001396352086487522	+1	PIK3CA,PIK3R1,NRAS,FGFR2,FGFR3
REAC:R-HSA-5654710	PI-3K cascade:FGFR3	0.0014806035582460046	0.0014806035582460046	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-1963642	PI3K events in ERBB2 signaling	0.0014806035582460046	0.0014806035582460046	+1	PIK3CA,EGFR,PIK3R1
REAC:R-HSA-2559585	Oncogene Induced Senescence	0.0016623620837510722	0.0016623620837510722	+1	TP53,CDKN2A,RB1,CDKN2C
REAC:R-HSA-3304347	Loss of Function of SMAD4 in Cancer	0.0016623620837510722	0.0016623620837510722	+1	SMAD4,SMAD2
REAC:R-HSA-8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	0.0016623620837510722	0.0016623620837510722	+1	RUNX1,CBFB
REAC:R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	0.0016623620837510722	0.0016623620837510722	+1	SMAD4,SMAD2
REAC:R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	0.0016623620837510722	0.0016623620837510722	+1	SMAD4,SMAD2
REAC:R-HSA-9649913	RAS GTPase cycle mutants	0.0016623620837510722	0.0016623620837510722	+1	KRAS,NRAS
REAC:R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.0017162632701600666	0.0017162632701600666	+1	TP53,CDKN1B,CDKN1A
REAC:R-HSA-109581	Apoptosis	0.0017162632701600666	0.0017162632701600666	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,AKT1,TLR4,HIST1H1C
REAC:R-HSA-198323	AKT phosphorylates targets in the cytosol	0.0017162632701600666	0.0017162632701600666	+1	AKT1,CDKN1B,CDKN1A
REAC:R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.0017162632701600666	0.0017162632701600666	+1	PIK3CA,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-1295596	Spry regulation of FGF signaling	0.0017162632701600666	0.0017162632701600666	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-9034015	Signaling by NTRK3 (TRKC)	0.0017162632701600666	0.0017162632701600666	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-69473	G2/M DNA damage checkpoint	0.001787064891214988	0.001787064891214988	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-5357801	Programmed Cell Death	0.001868768761460055	0.001868768761460055	+1	TP53,APC,CDKN2A,CTNNB1,CDH1,AKT1,TLR4,HIST1H1C
REAC:R-HSA-73894	DNA Repair	0.0018863830369538362	0.0018863830369538362	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,EP300,BRCA2,ATR,HIST1H2BD,ERCC2
REAC:R-HSA-597592	Post-translational protein modification	0.0018863830369538362	0.0018863830369538362	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,DNMT3A,KEAP1,BAP1,NPM1,STAG2,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,B4GALT3,SIN3A,HIST1H2BD,SMC1A,SMC3,SMAD2,AXIN2,RAD21
REAC:R-HSA-5683057	MAPK family signaling cascades	0.0018863830369538362	0.0018863830369538362	+1	EGFR,NF1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
REAC:R-HSA-114604	GPVI-mediated activation cascade	0.0019191968992464115	0.0019191968992464115	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
REAC:R-HSA-5654689	PI-3K cascade:FGFR1	0.001942639419782861	0.001942639419782861	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	0.001942639419782861	0.001942639419782861	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	0.001942639419782861	0.001942639419782861	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin	0.001942639419782861	0.001942639419782861	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	0.001942639419782861	0.001942639419782861	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-166520	Signaling by NTRKs	0.001942639419782861	0.001942639419782861	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	0.001942639419782861	0.001942639419782861	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	0.001942639419782861	0.001942639419782861	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-109704	PI3K Cascade	0.002022523938947087	0.002022523938947087	+1	PIK3CA,PIK3R1,FLT3,PTPN11
REAC:R-HSA-5673001	RAF/MAP kinase cascade	0.0021308588159243093	0.0021308588159243093	+1	EGFR,NF1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A
REAC:R-HSA-201681	TCF dependent signaling in response to WNT	0.0021308588159243093	0.0021308588159243093	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
REAC:R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.0023158318151642963	0.0023158318151642963	+1	TP53,RB1,HIST1H1C
REAC:R-HSA-5655253	Signaling by FGFR2 in disease	0.002436094188006021	0.002436094188006021	+1	PIK3CA,PIK3R1,NRAS,FGFR2
REAC:R-HSA-194138	Signaling by VEGF	0.0024438770425893575	0.0024438770425893575	+1	PIK3CA,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
REAC:R-HSA-69620	Cell Cycle Checkpoints	0.002451450179610373	0.002451450179610373	+1	TP53,CDKN2A,ATM,CDKN1B,BRCA1,CHEK2,CDKN1A,PPP2R1A,ATR,HIST1H2BD
REAC:R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.0026090965853205646	0.0026090965853205646	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-69560	Transcriptional activation of p53 responsive genes  	0.0026090965853205646	0.0026090965853205646	+1	TP53,CDKN1A
REAC:R-HSA-69895	Transcriptional  activation of  cell cycle inhibitor p21 	0.0026090965853205646	0.0026090965853205646	+1	TP53,CDKN1A
REAC:R-HSA-3656532	TGFBR1 KD Mutants in Cancer	0.0026090965853205646	0.0026090965853205646	+1	TGFBR2,SMAD2
REAC:R-HSA-8865999	MET activates PTPN11	0.0026090965853205646	0.0026090965853205646	+1	HGF,PTPN11
REAC:R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.0026090965853205646	0.0026090965853205646	+1	TGFBR2,SMAD2
REAC:R-HSA-74752	Signaling by Insulin receptor	0.0026090965853205646	0.0026090965853205646	+1	PIK3CA,PIK3R1,FLT3,NRAS,PTPN11
REAC:R-HSA-196299	Beta-catenin phosphorylation cascade	0.0026090965853205646	0.0026090965853205646	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5654720	PI-3K cascade:FGFR4	0.0026090965853205646	0.0026090965853205646	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-186712	Regulation of beta-cell development	0.0026090965853205646	0.0026090965853205646	+1	NOTCH1,AKT1,EP300,FOXA2
REAC:R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.0028862797093945174	0.0028862797093945174	+1	SMAD4,USP9X,TGFBR2,NCOR1,SMAD2
REAC:R-HSA-5654695	PI-3K cascade:FGFR2	0.0030467576514436982	0.0030467576514436982	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.0032851898215265117	0.0032851898215265117	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-6806834	Signaling by MET	0.003875955881471458	0.003875955881471458	+1	PIK3CA,PIK3R1,NRAS,HGF,PTPN11
REAC:R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.0038821595669261927	0.0038821595669261927	+1	SMAD4,USP9X,NCOR1,SMAD2
REAC:R-HSA-187037	Signaling by NTRK1 (TRKA)	0.004068303054632642	0.004068303054632642	+1	PIK3CA,PIK3R1,NRAS,BRAF,PPP2R1A
REAC:R-HSA-389513	CTLA4 inhibitory signaling	0.004082139041722119	0.004082139041722119	+1	AKT1,PPP2R1A,PTPN11
REAC:R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	0.004088585298068105	0.004088585298068105	+1	RUNX1,CBFB
REAC:R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	0.004088585298068105	0.004088585298068105	+1	TGFBR2,SMAD2
REAC:R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.004088585298068105	0.004088585298068105	+1	CTNNB1,EP300
REAC:R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.004093655063052746	0.004093655063052746	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2559580	Oxidative Stress Induced Senescence	0.005453777449767898	0.005453777449767898	+1	TP53,CDKN2A,MAP2K4,HIST1H2BD,CDKN2C,EZH2
REAC:R-HSA-69202	Cyclin E associated events during G1/S transition 	0.005498697895163564	0.005498697895163564	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-9645135	STAT5 Activation	0.005652825718020652	0.005652825718020652	+1	FLT3,PTPN11
REAC:R-HSA-8857538	PTK6 promotes HIF1A stabilization	0.005652825718020652	0.005652825718020652	+1	EGFR,LRRK2
REAC:R-HSA-8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	0.005652825718020652	0.005652825718020652	+1	RUNX1,CBFB
REAC:R-HSA-5654732	Negative regulation of FGFR3 signaling	0.005652825718020652	0.005652825718020652	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-9028335	Activated NTRK2 signals through PI3K	0.005652825718020652	0.005652825718020652	+1	PIK3CA,PIK3R1
REAC:R-HSA-9603381	Activated NTRK3 signals through PI3K	0.005652825718020652	0.005652825718020652	+1	PIK3CA,PIK3R1
REAC:R-HSA-8931987	RUNX1 regulates estrogen receptor mediated transcription	0.005652825718020652	0.005652825718020652	+1	RUNX1,CBFB
REAC:R-HSA-8939245	RUNX1 regulates transcription of genes involved in BCR signaling	0.005652825718020652	0.005652825718020652	+1	RUNX1,CBFB
REAC:R-HSA-8939256	RUNX1 regulates transcription of genes involved in WNT signaling	0.005652825718020652	0.005652825718020652	+1	RUNX1,CBFB
REAC:R-HSA-9022537	Loss of MECP2 binding ability to the NCoR/SMRT complex	0.005652825718020652	0.005652825718020652	+1	TBL1XR1,NCOR1
REAC:R-HSA-8849470	PTK6 Regulates Cell Cycle	0.005652825718020652	0.005652825718020652	+1	CDKN1B,CCND1
REAC:R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.005652825718020652	0.005652825718020652	+1	RB1,AR,CBFB
REAC:R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.005724143790283565	0.005724143790283565	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
REAC:R-HSA-75153	Apoptotic execution phase	0.006049267766785267	0.006049267766785267	+1	APC,CTNNB1,CDH1,HIST1H1C
REAC:R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.0064730512408144	0.0064730512408144	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-449147	Signaling by Interleukins	0.006516056079378542	0.006516056079378542	+1	TP53,PIK3CA,PIK3R1,GATA3,MAP2K4,AKT1,HGF,CCND1,CDKN1A,PPP2R1A,PTPN11,LIFR
REAC:R-HSA-69206	G1/S Transition	0.0068780091974718245	0.0068780091974718245	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A
REAC:R-HSA-2424491	DAP12 signaling	0.007028776808291738	0.007028776808291738	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-8941332	RUNX2 regulates genes involved in cell migration	0.007544561165047579	0.007544561165047579	+1	AKT1,CBFB
REAC:R-HSA-2179392	EGFR Transactivation by Gastrin	0.007544561165047579	0.007544561165047579	+1	EGFR,NRAS
REAC:R-HSA-5654726	Negative regulation of FGFR1 signaling	0.007740244647296532	0.007740244647296532	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.007740244647296532	0.007740244647296532	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.008401001052007041	0.008401001052007041	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-69541	Stabilization of p53	0.008401001052007041	0.008401001052007041	+1	TP53,CDKN2A,ATM,CHEK2
REAC:R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.008401001052007041	0.008401001052007041	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-5693538	Homology Directed Repair	0.008401001052007041	0.008401001052007041	+1	ATM,BRCA1,POLQ,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.008401001052007041	0.008401001052007041	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-6807070	PTEN Regulation	0.008401001052007041	0.008401001052007041	+1	TP53,PTEN,AKT1,MTOR,MECOM,EZH2
REAC:R-HSA-5218920	VEGFR2 mediated vascular permeability	0.008401001052007041	0.008401001052007041	+1	CTNNB1,AKT1,MTOR
REAC:R-HSA-5654733	Negative regulation of FGFR4 signaling	0.008401001052007041	0.008401001052007041	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.008401001052007041	0.008401001052007041	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.008401001052007041	0.008401001052007041	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-350054	Notch-HLH transcription pathway	0.009098919021231023	0.009098919021231023	+1	NOTCH1,TBL1XR1,NCOR1
REAC:R-HSA-5654727	Negative regulation of FGFR2 signaling	0.009098919021231023	0.009098919021231023	+1	BRAF,PPP2R1A,PTPN11
REAC:R-HSA-8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	0.009162726044525778	0.009162726044525778	+1	RUNX1,CBFB
REAC:R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	0.009162726044525778	0.009162726044525778	+1	RUNX1,EP300,CBFB,SIN3A,HIST1H2BD
REAC:R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.009162726044525778	0.009162726044525778	+1	CTNNB1,AXIN2
REAC:R-HSA-8951430	RUNX3 regulates WNT signaling	0.009162726044525778	0.009162726044525778	+1	CTNNB1,CCND1
REAC:R-HSA-8851805	MET activates RAS signaling	0.009162726044525778	0.009162726044525778	+1	NRAS,HGF
REAC:R-HSA-8986944	Transcriptional Regulation by MECP2	0.009164038895150044	0.009164038895150044	+1	PTEN,SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-8943724	Regulation of PTEN gene transcription	0.009164038895150044	0.009164038895150044	+1	TP53,MTOR,MECOM,EZH2
REAC:R-HSA-5673000	RAF activation	0.00972865451382174	0.00972865451382174	+1	NRAS,BRAF,PPP2R1A
REAC:R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.010551182813640356	0.010551182813640356	+1	SMAD4,TGFBR2,SMAD2
REAC:R-HSA-6804758	Regulation of TP53 Activity through Acetylation	0.010551182813640356	0.010551182813640356	+1	TP53,AKT1,EP300
REAC:R-HSA-9022692	Regulation of MECP2 expression and activity	0.010551182813640356	0.010551182813640356	+1	SIN3A,TBL1XR1,NCOR1
REAC:R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.010551182813640356	0.010551182813640356	+1	SMAD4,SIN3A,SMAD2
REAC:R-HSA-1250342	PI3K events in ERBB4 signaling	0.011120782895015982	0.011120782895015982	+1	PIK3CA,PIK3R1
REAC:R-HSA-6811555	PI5P Regulates TP53 Acetylation	0.011120782895015982	0.011120782895015982	+1	TP53,EP300
REAC:R-HSA-198203	PI3K/AKT activation	0.011120782895015982	0.011120782895015982	+1	PIK3CA,PIK3R1
REAC:R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	0.011120782895015982	0.011120782895015982	+1	NRAS,PTPN11
REAC:R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.011120782895015982	0.011120782895015982	+1	CTNNB1,CDH1
REAC:R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.01131107032417852	0.01131107032417852	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5655302	Signaling by FGFR1 in disease	0.012342602673849153	0.012342602673849153	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-2172127	DAP12 interactions	0.013371363094101878	0.013371363094101878	+1	PIK3CA,PIK3R1,NRAS
REAC:R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.013371363094101878	0.013371363094101878	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	0.013531164238971247	0.013531164238971247	+1	RUNX1,CBFB
REAC:R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.013600533090587077	0.013600533090587077	+1	ATM,BRCA1,BRCA2,ATR
REAC:R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.01431907296595874	0.01431907296595874	+1	CDKN2A,CDKN1B,CDKN1A,HIST1H2BD,CDKN2C
REAC:R-HSA-4791275	Signaling by WNT in cancer	0.01431907296595874	0.01431907296595874	+1	APC,CTNNB1,PPP2R1A
REAC:R-HSA-5693537	Resolution of D-Loop Structures	0.01431907296595874	0.01431907296595874	+1	ATM,BRCA1,BRCA2
REAC:R-HSA-392499	Metabolism of proteins	0.014535518385223548	0.014535518385223548	+1	TP53,PTEN,APC,VHL,CDKN2A,GATA3,FBXW7,CTNNB1,DNMT3A,KEAP1,BAP1,NPM1,RPL22,STAG2,AR,BRCA1,EP300,SMAD4,USP9X,ASXL1,TGFBR2,B4GALT3,SIN3A,HIST1H2BD,EIF4A2,SMC1A,SMC3,RPL5,SMAD2,AXIN2,RAD21
REAC:R-HSA-6802957	Oncogenic MAPK signaling	0.014755057821813019	0.014755057821813019	+1	KRAS,NF1,NRAS,BRAF
REAC:R-HSA-195721	Signaling by WNT	0.014755057821813019	0.014755057821813019	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
REAC:R-HSA-351906	Apoptotic cleavage of cell adhesion  proteins	0.015789120105977394	0.015789120105977394	+1	CTNNB1,CDH1
REAC:R-HSA-1433617	Regulation of signaling by NODAL	0.015789120105977394	0.015789120105977394	+1	ACVR1B,ACVR2A
REAC:R-HSA-179812	GRB2 events in EGFR signaling	0.015789120105977394	0.015789120105977394	+1	EGFR,NRAS
REAC:R-HSA-3214841	PKMTs methylate histone lysines	0.016022687123517492	0.016022687123517492	+1	SETD2,NSD1,MECOM,EZH2
REAC:R-HSA-1980143	Signaling by NOTCH1	0.016022687123517492	0.016022687123517492	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REAC:R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	0.01620427945359641	0.01620427945359641	+1	EP300,TBL1XR1,NCOR1
REAC:R-HSA-111465	Apoptotic cleavage of cellular proteins	0.017376203925798497	0.017376203925798497	+1	APC,CTNNB1,CDH1
REAC:R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.017376203925798497	0.017376203925798497	+1	ATM,BRCA1,ATR
REAC:R-HSA-180336	SHC1 events in EGFR signaling	0.01832427499958764	0.01832427499958764	+1	EGFR,NRAS
REAC:R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.01832427499958764	0.01832427499958764	+1	TP53,ATM
REAC:R-HSA-5689896	Ovarian tumor domain proteases	0.018380413633033964	0.018380413633033964	+1	TP53,PTEN,APC
REAC:R-HSA-8853659	RET signaling	0.018380413633033964	0.018380413633033964	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-69481	G2/M Checkpoints	0.018380413633033964	0.018380413633033964	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
REAC:R-HSA-5675221	Negative regulation of MAPK pathway	0.019698824470993113	0.019698824470993113	+1	NRAS,BRAF,PPP2R1A
REAC:R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	0.020881697004074766	0.020881697004074766	+1	ARHGAP35,NRAS
REAC:R-HSA-165159	mTOR signalling	0.020881697004074766	0.020881697004074766	+1	STK11,AKT1,MTOR
REAC:R-HSA-1963640	GRB2 events in ERBB2 signaling	0.020881697004074766	0.020881697004074766	+1	EGFR,NRAS
REAC:R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.020881697004074766	0.020881697004074766	+1	RB1,PPP2R1A
REAC:R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.021042077147342932	0.021042077147342932	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
REAC:R-HSA-3214858	RMTs methylate histone arginines	0.022070148354771755	0.022070148354771755	+1	ARID1A,PBRM1,DNMT3A,CCND1
REAC:R-HSA-3899300	SUMOylation of transcription cofactors	0.022076957520219622	0.022076957520219622	+1	NPM1,EP300,SIN3A
REAC:R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.022993825029984757	0.022993825029984757	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-4839748	AMER1 mutants destabilize the destruction complex	0.02301499364056813	0.02301499364056813	+1	APC,PPP2R1A
REAC:R-HSA-5654706	FRS-mediated FGFR3 signaling	0.02301499364056813	0.02301499364056813	+1	NRAS,PTPN11
REAC:R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.02301499364056813	0.02301499364056813	+1	APC,PPP2R1A
REAC:R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.02301499364056813	0.02301499364056813	+1	TP53,AKT1
REAC:R-HSA-8941856	RUNX3 regulates NOTCH signaling	0.02301499364056813	0.02301499364056813	+1	NOTCH1,EP300
REAC:R-HSA-1500931	Cell-Cell communication	0.02301499364056813	0.02301499364056813	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,PTPN11
REAC:R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.02301499364056813	0.02301499364056813	+1	APC,PPP2R1A
REAC:R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.02301499364056813	0.02301499364056813	+1	APC,PPP2R1A
REAC:R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	0.02301499364056813	0.02301499364056813	+1	APC,PPP2R1A
REAC:R-HSA-4839744	truncated APC mutants destabilize the destruction complex	0.02301499364056813	0.02301499364056813	+1	APC,PPP2R1A
REAC:R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.023984587769335722	0.023984587769335722	+1	CEBPA,EP300,TBL1XR1,NCOR1
REAC:R-HSA-1483255	PI Metabolism	0.024840047989895152	0.024840047989895152	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
REAC:R-HSA-5628897	TP53 Regulates Metabolic Genes	0.024840047989895152	0.024840047989895152	+1	TP53,PTEN,AKT1,MTOR
REAC:R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.026021932044158477	0.026021932044158477	+1	EGFR,KIT
REAC:R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.026383567251797736	0.026383567251797736	+1	ATM,BRCA1,BRCA2,ATR,HIST1H2BD
REAC:R-HSA-6802949	Signaling by RAS mutants	0.02648097731586001	0.02648097731586001	+1	KRAS,NRAS,BRAF
REAC:R-HSA-9646304	Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	0.02648097731586001	0.02648097731586001	+1	CDKN2A
REAC:R-HSA-9646303	Evasion of Oncogene Induced Senescence Due to p14ARF Defects	0.02648097731586001	0.02648097731586001	+1	CDKN2A
REAC:R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.02648097731586001	0.02648097731586001	+1	KRAS,NRAS,BRAF
REAC:R-HSA-5674404	PTEN Loss of Function in Cancer	0.02648097731586001	0.02648097731586001	+1	PTEN
REAC:R-HSA-2978092	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	0.02648097731586001	0.02648097731586001	+1	IDH1
REAC:R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	0.02648097731586001	0.02648097731586001	+1	APC
REAC:R-HSA-3642279	TGFBR2 MSI Frameshift Mutants in Cancer	0.02648097731586001	0.02648097731586001	+1	TGFBR2
REAC:R-HSA-8853333	Signaling by FGFR2 fusions	0.02648097731586001	0.02648097731586001	+1	FGFR2
REAC:R-HSA-2023837	Signaling by FGFR2 amplification mutants	0.02648097731586001	0.02648097731586001	+1	FGFR2
REAC:R-HSA-9649948	Signaling downstream of RAS mutants	0.02648097731586001	0.02648097731586001	+1	KRAS,NRAS,BRAF
REAC:R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.02648097731586001	0.02648097731586001	+1	KRAS,NRAS,BRAF
REAC:R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	0.02648097731586001	0.02648097731586001	+1	EP300,TBL1XR1,NCOR1
REAC:R-HSA-2033515	t(4;14) translocations of FGFR3	0.02648097731586001	0.02648097731586001	+1	FGFR3
REAC:R-HSA-389542	NADPH regeneration	0.02648097731586001	0.02648097731586001	+1	IDH1
REAC:R-HSA-3371556	Cellular response to heat stress	0.027278869434006123	0.027278869434006123	+1	ATM,MTOR,EP300,ATR
REAC:R-HSA-912446	Meiotic recombination	0.027278869434006123	0.027278869434006123	+1	ATM,BRCA1,BRCA2,HIST1H2BD
REAC:R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.027278869434006123	0.027278869434006123	+1	TLR4,PTPN11
REAC:R-HSA-5654693	FRS-mediated FGFR1 signaling	0.027278869434006123	0.027278869434006123	+1	NRAS,PTPN11
REAC:R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	0.027278869434006123	0.027278869434006123	+1	PIK3CA,PIK3R1
REAC:R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.027278869434006123	0.027278869434006123	+1	NOTCH1,EP300
REAC:R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.027278869434006123	0.027278869434006123	+1	EGFR,NRAS
REAC:R-HSA-9614657	FOXO-mediated transcription of cell death genes	0.027278869434006123	0.027278869434006123	+1	STK11,EP300
REAC:R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.028087549390901207	0.028087549390901207	+1	PIK3CA,PIK3R1,PTPN11
REAC:R-HSA-9012852	Signaling by NOTCH3	0.029575810122057	0.029575810122057	+1	EGFR,NOTCH1,EP300
REAC:R-HSA-168256	Immune System	0.029575810122057	0.029575810122057	+1	TP53,PIK3CA,PTEN,VHL,EGFR,NF1,PIK3R1,GATA3,FBXW7,CTNNB1,MAP3K1,FLT3,KEAP1,CDH1,NRAS,IDH1,MAP2K4,AKT1,BRAF,HGF,MTOR,TLR4,KIT,PDGFRA,EP300,CCND1,CDKN1A,PPP2R1A,EIF4A2,PTPN11,LIFR
REAC:R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.029797823777166506	0.029797823777166506	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-432142	Platelet sensitization by LDL	0.030236980557158667	0.030236980557158667	+1	PPP2R1A,PTPN11
REAC:R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.030553260092035413	0.030553260092035413	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.030553260092035413	0.030553260092035413	+1	CTNNB1,EP300,HIST1H2BD,AXIN2
REAC:R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.030553260092035413	0.030553260092035413	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-3214842	HDMs demethylate histones	0.03241969446112225	0.03241969446112225	+1	KDM6A,KDM5C,ARID5B
REAC:R-HSA-3232118	SUMOylation of transcription factors	0.03286954856887142	0.03286954856887142	+1	TP53,CDKN2A
REAC:R-HSA-1250196	SHC1 events in ERBB2 signaling	0.03286954856887142	0.03286954856887142	+1	EGFR,NRAS
REAC:R-HSA-1368082	RORA activates gene expression	0.03286954856887142	0.03286954856887142	+1	EP300,TBL1XR1
REAC:R-HSA-5654712	FRS-mediated FGFR4 signaling	0.03286954856887142	0.03286954856887142	+1	NRAS,PTPN11
REAC:R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.03286954856887142	0.03286954856887142	+1	TP53,EP300
REAC:R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.033270870830258	0.033270870830258	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.033270870830258	0.033270870830258	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.03437493816494685	0.03437493816494685	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-166166	MyD88-independent TLR4 cascade 	0.0353925454165952	0.0353925454165952	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling 	0.0353925454165952	0.0353925454165952	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-5654700	FRS-mediated FGFR2 signaling	0.03552502765342836	0.03552502765342836	+1	NRAS,PTPN11
REAC:R-HSA-210745	Regulation of gene expression in beta cells	0.03552502765342836	0.03552502765342836	+1	AKT1,FOXA2
REAC:R-HSA-8876384	Listeria monocytogenes entry into host cells	0.03552502765342836	0.03552502765342836	+1	CTNNB1,CDH1
REAC:R-HSA-8978934	Metabolism of cofactors	0.03552502765342836	0.03552502765342836	+1	IDH1,AKT1
REAC:R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.03593232415460709	0.03593232415460709	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.03593232415460709	0.03593232415460709	+1	IDH2,TBL1XR1,NCOR1
REAC:R-HSA-109606	Intrinsic Pathway for Apoptosis	0.03593232415460709	0.03593232415460709	+1	TP53,CDKN2A,AKT1
REAC:R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.03593232415460709	0.03593232415460709	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REAC:R-HSA-5693607	Processing of DNA double-strand break ends	0.03692222873123867	0.03692222873123867	+1	ATM,BRCA1,ATR,HIST1H2BD
REAC:R-HSA-8941858	Regulation of RUNX3 expression and activity	0.037560667231688466	0.037560667231688466	+1	CDKN2A,EP300,CBFB
REAC:R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	0.03819825942969957	0.03819825942969957	+1	NOTCH1,EP300
REAC:R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.03819825942969957	0.03819825942969957	+1	TP53,ATM
REAC:R-HSA-5621575	CD209 (DC-SIGN) signaling	0.03819825942969957	0.03819825942969957	+1	NRAS,EP300
REAC:R-HSA-168898	Toll-like Receptor Cascades	0.03886187431220711	0.03886187431220711	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REAC:R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.04159159878522457	0.04159159878522457	+1	TP53,NPM1
REAC:R-HSA-912631	Regulation of signaling by CBL	0.04159159878522457	0.04159159878522457	+1	PIK3CA,PIK3R1
REAC:R-HSA-9630791	Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	0.04475675604823455	0.04475675604823455	+1	CDKN2A
REAC:R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.04475675604823455	0.04475675604823455	+1	SMAD4,SMAD2
REAC:R-HSA-9632697	Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	0.04475675604823455	0.04475675604823455	+1	CDKN2A
REAC:R-HSA-8951911	RUNX3 regulates RUNX1-mediated transcription	0.04475675604823455	0.04475675604823455	+1	CBFB
REAC:R-HSA-3645790	TGFBR2 Kinase Domain Mutants in Cancer	0.04475675604823455	0.04475675604823455	+1	TGFBR2
REAC:R-HSA-9645722	Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	0.04475675604823455	0.04475675604823455	+1	CDKN2A
REAC:R-HSA-9645723	Diseases of Programmed Cell Death	0.04475675604823455	0.04475675604823455	+1	CDKN2A
REAC:R-HSA-113510	E2F mediated regulation of DNA replication	0.04475675604823455	0.04475675604823455	+1	RB1,PPP2R1A
REAC:R-HSA-9022538	Loss of MECP2 binding ability to 5mC-DNA	0.04475675604823455	0.04475675604823455	+1	SIN3A
REAC:R-HSA-3642278	Loss of Function of TGFBR2 in Cancer	0.04475675604823455	0.04475675604823455	+1	TGFBR2
REAC:R-HSA-6804754	Regulation of TP53 Expression	0.04475675604823455	0.04475675604823455	+1	TP53
REAC:R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	0.04721230254496632	0.04721230254496632	+1	CDKN1B,CCND1,CDKN1A
REAC:R-HSA-373753	Nephrin family interactions	0.0476952186083865	0.0476952186083865	+1	PIK3CA,PIK3R1