GO.ID	Description	p.Val	FDR	Phenotype	Genes
SIGNALING PATHWAYS IN GLIOBLASTOMA%WIKIPATHWAYS_20190610%WP2261%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2261_r98349	3.199484550024705e-28	3.199484550024705e-28	+1	TP53,PIK3CA,PTEN,KRAS,EGFR,NF1,PIK3R1,CDKN2A,RB1,NRAS,MAP2K4,AKT1,BRAF,PIK3CG,ATM,CDKN1B,BRCA1,PDGFRA,EP300,FGFR2,CCND1,BRCA2,CDKN1A,CDKN2C
PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20190610%WP3651%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3651_r89271	5.8955155117285645e-22	5.8955155117285645e-22	+1	TP53,PIK3CA,PTEN,ARID1A,NOTCH1,FBXW7,CEBPA,KDM6A,AKT1,ATM,ARID5B,ATRX,BRCA1,CHEK2,SETD2,EP300,SMC1A,NSD1,NCOR1
INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20190610%WP1984%HOMO SAPIENS	http://www.wikipathways.org/instance/WP1984_r103002	2.876549147287776e-20	2.876549147287776e-20	+1	TP53,PTEN,KRAS,EGFR,NF1,RB1,CTNNB1,CDH1,STK11,AKT1,BRAF,AR,ATM,MTOR,BRCA1,CHEK2,EP300,CCND1,SMAD4,BRCA2,TGFBR2,ATR,SMAD2
ENDOMETRIAL CANCER%WIKIPATHWAYS_20190610%WP4155%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4155_r103782	3.914669079982795e-19	3.914669079982795e-19	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,PIK3R1,CTNNB1,CDH1,NRAS,AKT1,BRAF,FGFR2,CCND1,FGFR3,CDKN1A,AXIN2
BREAST CANCER PATHWAY%WIKIPATHWAYS_20190610%WP4262%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4262_r103781	7.319756515351421e-19	7.319756515351421e-19	+1	TP53,PIK3CA,PTEN,APC,KRAS,EGFR,PIK3R1,RB1,NOTCH1,CTNNB1,NRAS,AKT1,BRAF,ATM,MTOR,BRCA1,KIT,CCND1,BRCA2,CDKN1A,ATR,AXIN2
P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398	p53 pathway feedback loops 2	4.0584012212404e-15	4.0584012212404e-15	+1	TP53,PIK3CA,PTEN,KRAS,PIK3R1,RB1,CTNNB1,NRAS,AKT1,PIK3CG,ATM,CDKN1A,ATR
PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20190610%WP4263%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4263_r103768	4.0584012212404e-15	4.0584012212404e-15	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CDKN2A,RB1,AKT1,BRAF,MTOR,CCND1,SMAD4,BRCA2,TGFBR2,CDKN1A,SMAD2
DNA DAMAGE RESPONSE (ONLY ATM DEPENDENT)%WIKIPATHWAYS_20190610%WP710%HOMO SAPIENS	http://www.wikipathways.org/instance/WP710_r104309	1.0391931742971003e-14	1.0391931742971003e-14	+1	TP53,PIK3CA,PTEN,APC,KRAS,PIK3R1,CDKN2A,CTNNB1,MAP3K1,NRAS,AKT1,PIK3CG,ATM,CDKN1B,CCND1,SMAD4,CDKN1A
TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR	TGF_beta_Receptor	1.4302860584657525e-14	1.4302860584657525e-14	+1	TP53,PIK3CA,PIK3R1,RB1,CTNNB1,CTCF,RUNX1,STK11,AKT1,AR,SOX9,MTOR,BRCA1,EP300,CCND1,SMAD4,TGFBR2,CDKN1A,PPP2R1A,SMAD2,AXIN2
CELL CYCLE%WIKIPATHWAYS_20190610%WP179%HOMO SAPIENS	http://www.wikipathways.org/instance/WP179_r103430	2.7287156334397627e-14	2.7287156334397627e-14	+1	TP53,CDKN2A,RB1,STAG2,ATM,CDKN1B,CHEK2,EP300,CCND1,SMAD4,CDKN1A,ATR,SMC1A,SMC3,SMAD2,RAD21,CDKN2C
EXTRACELLULAR VESICLE-MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20190610%WP2870%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2870_r88052	7.652726568911857e-14	7.652726568911857e-14	+1	APC,KRAS,EGFR,CTNNB1,NRAS,AKT1,HGF,MTOR,SMAD4,TGFBR2,SMAD2
BLADDER CANCER%WIKIPATHWAYS_20190610%WP2828%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2828_r103783	7.652726568911857e-14	7.652726568911857e-14	+1	TP53,KRAS,EGFR,PIK3R1,CDKN2A,RB1,CDH1,NRAS,BRAF,CCND1,FGFR3,CDKN1A
BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY	BIOCARTA_CTCF_PATHWAY	2.154506642849097e-13	2.154506642849097e-13	+1	TP53,PIK3CA,PTEN,PIK3R1,CDKN2A,PIK3CG,CDKN1B,MTOR,SMAD4,TGFBR2
ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR	AndrogenReceptor	2.3292513307745963e-12	2.3292513307745963e-12	+1	PTEN,EGFR,PIK3R1,RB1,CTNNB1,RUNX1,CEBPA,AKT1,AR,BRCA1,FOXA1,EP300,CCND1,SMAD4,SIN3A,NSD1
ANDROGEN RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP138%HOMO SAPIENS	http://www.wikipathways.org/instance/WP138_r79958	2.3292513307745963e-12	2.3292513307745963e-12	+1	PTEN,EGFR,PIK3R1,RB1,CTNNB1,AKT1,AR,BRCA1,EP300,CCND1,SMAD4,CDKN1A,SIN3A,NCOR1
ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP673%HOMO SAPIENS	http://www.wikipathways.org/instance/WP673_r102179	2.3292513307745963e-12	2.3292513307745963e-12	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,NRAS,MAP2K4,AKT1,BRAF,CDKN1B,ERBB4,MTOR,CCND1,CDKN1A
PROTEIN AUTOPHOSPHORYLATION%GOBP%GO:0046777	protein autophosphorylation	2.5608058513437843e-12	2.5608058513437843e-12	+1	EGFR,FLT3,STK11,AKT1,ATM,ERBB4,MTOR,LRRK2,CHEK2,KIT,PDGFRA,FGFR2,FGFR3,TAF1,ATR,CDK12,ACVR1B
REGULATION OF CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:1902806	regulation of cell cycle G1/S phase transition	3.297745409606051e-12	3.297745409606051e-12	+1	TP53,PTEN,EGFR,CDKN2A,RB1,FBXW7,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,TAF1,CDKN2C,EZH2
INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20190610%WP1971%HOMO SAPIENS	http://www.wikipathways.org/instance/WP1971_r103003	1.0636350571378735e-11	1.0636350571378735e-11	+1	TP53,PTEN,RB1,AKT1,ATM,CDKN1B,BRCA1,CHEK2,CDKN1A,ATR,SMAD2
ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 69%8939211	ESR-mediated signaling	1.563458687120104e-11	1.563458687120104e-11	+1	PIK3CA,KRAS,EGFR,PIK3R1,GATA3,RUNX1,NRAS,AKT1,STAG2,CDKN1B,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
NON-SMALL CELL LUNG CANCER%WIKIPATHWAYS_20190610%WP4255%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4255_r96916	2.221465923025671e-11	2.221465923025671e-11	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CDKN2A,RB1,NRAS,AKT1,BRAF,CCND1,CDKN1A
TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR	TGF_beta_Receptor	2.5190584685387645e-11	2.5190584685387645e-11	+1	TP53,PIK3R1,RB1,CTNNB1,CTCF,STK11,AKT1,AR,SOX9,BRCA1,EP300,CCND1,SMAD4,TGFBR2,CDKN1A,SMAD2,AXIN2
BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY	BIOCARTA_G1_PATHWAY	9.728966410180711e-11	9.728966410180711e-11	+1	TP53,CDKN2A,RB1,ATM,CDKN1B,CCND1,SMAD4,CDKN1A,ATR
CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20190610%WP4216%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4216_r103785	9.728966410180711e-11	9.728966410180711e-11	+1	TP53,APC,KRAS,CTNNB1,AKT1,BRAF,CCND1,SMAD4,TGFBR2,CDKN1A,SMAD2,AXIN2
NEGATIVE REGULATION OF TRANSFERASE ACTIVITY%GOBP%GO:0051348	negative regulation of transferase activity	9.749564564378341e-11	9.749564564378341e-11	+1	TP53,PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,EIF4A2,MAPK8IP1,RPL5
REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0010717	regulation of epithelial to mesenchymal transition	1.0595360710943182e-10	1.0595360710943182e-10	+1	PTEN,NOTCH1,CTNNB1,EPHA3,MTOR,FOXA1,SMAD4,FOXA2,TGFBR2,SMAD2,AXIN2,EZH2
P53 PATHWAY%PANTHER PATHWAY%P00059	p53 pathway	1.526187332827688e-10	1.526187332827688e-10	+1	TP53,PIK3CA,PTEN,AKT1,ATM,CHEK2,EP300,CDKN1A,ATR,SIN3A
MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20190610%WP2857%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2857_r102044	1.5914211869304084e-10	1.5914211869304084e-10	+1	GATA3,NFE2L2,TBX3,KDM6A,ARID5B,FOXA1,SETD2,CCND1,SMAD4,FOXA2,SOX17,PHF6,ACVR2A,SMAD2,AXIN2
PI3K-AKT-MTOR SIGNALING PATHWAY AND THERAPEUTIC OPPORTUNITIES%WIKIPATHWAYS_20190610%WP3844%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3844_r89952	1.5914211869304084e-10	1.5914211869304084e-10	+1	PIK3CA,PTEN,KRAS,PIK3R1,NRAS,AKT1,PIK3CG,CDKN1B,MTOR
PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY	PID_CMYB_PATHWAY	3.072736160761547e-10	3.072736160761547e-10	+1	KRAS,CDKN2A,GATA3,NRAS,CEBPA,CDKN1B,KIT,EP300,CCND1,CDKN1A,SIN3A,NCOR1
C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK	C-MYB transcription factor network	3.072736160761547e-10	3.072736160761547e-10	+1	KRAS,CDKN2A,GATA3,NRAS,CEBPA,CDKN1B,KIT,EP300,CCND1,CDKN1A,SIN3A,NCOR1
PI3K AKT SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 69%2219528	PI3K AKT Signaling in Cancer	6.053557597522366e-10	6.053557597522366e-10	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,CDKN1B,HGF,MTOR,KIT,PDGFRA,CDKN1A,PTPN11
ESC PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20190610%WP3931%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3931_r102153	1.0071259432349015e-9	1.0071259432349015e-9	+1	PTEN,APC,EGFR,CTNNB1,AKT1,BRAF,MTOR,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11,LIFR
REGULATION OF G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:2000045	regulation of G1/S transition of mitotic cell cycle	2.2777779714717456e-9	2.2777779714717456e-9	+1	TP53,PTEN,EGFR,CDKN2A,RB1,AKT1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	3.155136722031093e-9	3.155136722031093e-9	+1	PIK3CA,APC,PIK3R1,CTNNB1,MAP3K1,CDH1,MAP2K4,AKT1,HGF,MTOR,PTPN11
PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY	PID_MET_PATHWAY	3.5334313511706197e-9	3.5334313511706197e-9	+1	PIK3CA,APC,PIK3R1,CTNNB1,MAP3K1,CDH1,MAP2K4,AKT1,HGF,MTOR,PTPN11
PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY	PID_SMAD2_3NUCLEAR_PATHWAY	3.952359264532513e-9	3.952359264532513e-9	+1	GATA3,RUNX1,AKT1,AR,EP300,SMAD4,CDKN1A,CBFB,SIN3A,NCOR1,SMAD2
REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING	Regulation of nuclear SMAD2 3 signaling	4.4157249370622455e-9	4.4157249370622455e-9	+1	GATA3,RUNX1,AKT1,AR,EP300,SMAD4,CDKN1A,CBFB,SIN3A,NCOR1,SMAD2
MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20190610%WP3584%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3584_r97933	6.182833036387041e-9	6.182833036387041e-9	+1	NF1,CTCF,AKT1,MTOR,TET2,TAF1,SIN3A,SMC3,NCOR1,EZH2
PATHWAYS IN CLEAR CELL RENAL CELL CARCINOMA%WIKIPATHWAYS_20190610%WP4018%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4018_r98359	7.140679906561649e-9	7.140679906561649e-9	+1	PTEN,VHL,PBRM1,EGFR,BAP1,AKT1,KDM5C,MTOR,SETD2,PDGFRA,EP300
NEGATIVE REGULATION OF GROWTH%GOBP%GO:0045926	negative regulation of growth	7.608321625004589e-9	7.608321625004589e-9	+1	TP53,PTEN,CDKN2A,NOTCH1,STK11,CDKN1B,WT1,SMAD4,FGFR3,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
ARYL HYDROCARBON RECEPTOR%WIKIPATHWAYS_20190610%WP2586%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2586_r91687	1.1457618238579449e-8	1.1457618238579449e-8	+1	KRAS,EGFR,NF1,RB1,NFE2L2,NRAS,CDKN1B,EP300,CDKN1A
NEGATIVE REGULATION OF G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	1.4035375958158699e-8	1.4035375958158699e-8	+1	TP53,PTEN,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
NEGATIVE REGULATION OF KINASE ACTIVITY%GOBP%GO:0033673	negative regulation of kinase activity	1.5673131460235077e-8	1.5673131460235077e-8	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,FOXA2,CDKN1A,PPP2R1A,MAPK8IP1
PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY	PID_ECADHERIN_KERATINOCYTE_PATHWAY	1.5673131460235077e-8	1.5673131460235077e-8	+1	PIK3CA,EGFR,PIK3R1,CTNNB1,CDH1,AKT1,AJUBA
DNA DAMAGE RESPONSE%WIKIPATHWAYS_20190610%WP707%HOMO SAPIENS	http://www.wikipathways.org/instance/WP707_r94731	1.5673131460235077e-8	1.5673131460235077e-8	+1	TP53,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR,SMC1A
E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES	E-cadherin signaling in keratinocytes	1.5673131460235077e-8	1.5673131460235077e-8	+1	PIK3CA,EGFR,PIK3R1,CTNNB1,CDH1,AKT1,AJUBA
HIPPO-MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20190610%WP4541%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4541_r103434	1.5829616266420006e-8	1.5829616266420006e-8	+1	KRAS,EGFR,CTNNB1,FLT3,CDH1,NRAS,AJUBA,KIT,PDGFRA,FGFR2,CCND1,FGFR3
NEGATIVE REGULATION OF CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:1902807	negative regulation of cell cycle G1/S phase transition	1.5829616266420006e-8	1.5829616266420006e-8	+1	TP53,PTEN,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 69%8878159	Transcriptional regulation by RUNX3	1.6857773783478684e-8	1.6857773783478684e-8	+1	TP53,KRAS,CDKN2A,NOTCH1,CTNNB1,RUNX1,EP300,CCND1,SMAD4,CDKN1A,CBFB
PHOTODYNAMIC THERAPY-INDUCED AP-1 SURVIVAL SIGNALING.%WIKIPATHWAYS_20190610%WP3611%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3611_r90923	1.6857773783478684e-8	1.6857773783478684e-8	+1	TP53,EGFR,CDKN2A,RB1,NFE2L2,MAP2K4,PDGFRA,CCND1,CDKN1A
ANGIOGENESIS%PANTHER PATHWAY%P00005	Angiogenesis	1.9013543634203717e-8	1.9013543634203717e-8	+1	PIK3CA,APC,PIK3R1,NOTCH1,CTNNB1,MAP3K1,NRAS,MAP2K4,EPHA3,AKT1,BRAF,PIK3CG,PDGFRA
MIRNA REGULATION OF PROSTATE CANCER SIGNALING PATHWAYS%WIKIPATHWAYS_20190610%WP3981%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3981_r97532	1.940651275758447e-8	1.940651275758447e-8	+1	TP53,PIK3CA,KRAS,CTNNB1,AR,CDKN1B,MTOR,CCND1,CDKN1A
REGULATION OF PROTEIN KINASE B SIGNALING%GOBP%GO:0051896	regulation of protein kinase B signaling	2.2984228887820054e-8	2.2984228887820054e-8	+1	PIK3CA,PTEN,EGFR,PIK3R1,GATA3,AKT1,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
GLAND DEVELOPMENT%GOBP%GO:0048732	gland development	2.2984228887820054e-8	2.2984228887820054e-8	+1	NF1,ARHGAP35,TBX3,CEBPA,AKT1,AR,SOX9,WT1,ERBB4,ARID5B,ELF3,FGFR2
DNA IR-DOUBLE STRAND BREAKS (DSBS) AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20190610%WP3959%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3959_r101991	3.112943292084156e-8	3.112943292084156e-8	+1	TP53,CDKN2A,ATM,BRCA1,CHEK2,BRCA2,ATR,SMC1A,SMC3
EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20190610%WP4239%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4239_r103784	3.266130748072647e-8	3.266130748072647e-8	+1	TP53,PIK3CA,KRAS,PIK3R1,NOTCH1,CTNNB1,CDH1,MAP2K4,AKT1,SMAD4,TGFBR2,SMAD2,EZH2
POSITIVE REGULATION OF CELL CYCLE PROCESS%GOBP%GO:0090068	positive regulation of cell cycle process	3.569839460871227e-8	3.569839460871227e-8	+1	TP53,EGFR,RB1,NPM1,AKT1,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CCND1,CDKN1A,RAD21,EZH2
BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY	BIOCARTA_G2_PATHWAY	3.645173750091598e-8	3.645173750091598e-8	+1	TP53,ATM,BRCA1,CHEK2,EP300,CDKN1A,ATR
ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING	ErbB1 downstream signaling	3.860059080797249e-8	3.860059080797249e-8	+1	PIK3CA,KRAS,EGFR,PIK3R1,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,MTOR,PPP2R1A
REGULATION OF CYCLIN-DEPENDENT PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	4.014958173809979e-8	4.014958173809979e-8	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY	PID_ERBB1_DOWNSTREAM_PATHWAY	4.1455884578287274e-8	4.1455884578287274e-8	+1	PIK3CA,KRAS,EGFR,PIK3R1,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,MTOR,PPP2R1A
MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20190610%WP4205%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4205_r97130	4.544657910274931e-8	4.544657910274931e-8	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,BRAF,HGF,CDKN1A,PTPN11
SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.4	SUMO E3 ligases SUMOylate target proteins	4.919762907359236e-8	4.919762907359236e-8	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
NEGATIVE REGULATION OF PROTEIN KINASE ACTIVITY%GOBP%GO:0006469	negative regulation of protein kinase activity	5.2112246962318614e-8	5.2112246962318614e-8	+1	PTEN,APC,NF1,CDKN2A,RB1,NPM1,CRIPAK,CEBPA,AKT1,CDKN1B,CDKN1A,PPP2R1A,MAPK8IP1
BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY	BIOCARTA_RACCYCD_PATHWAY	6.11398287147327e-8	6.11398287147327e-8	+1	PIK3CA,PIK3R1,RB1,AKT1,CDKN1B,CCND1,CDKN1A
REGULATION OF CYCLIN-DEPENDENT PROTEIN KINASE ACTIVITY%GOBP%GO:1904029	regulation of cyclin-dependent protein kinase activity	6.781019247465775e-8	6.781019247465775e-8	+1	PTEN,APC,EGFR,CDKN2A,CEBPA,AKT1,CDKN1B,CCND1,CDKN1A,CDKN2C
SUMOYLATION%REACTOME%R-HSA-2990846.3	SUMOylation	7.126640101211341e-8	7.126640101211341e-8	+1	TP53,VHL,CDKN2A,DNMT3A,NPM1,STAG2,AR,BRCA1,EP300,SIN3A,SMC1A,SMC3,RAD21
NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP61%HOMO SAPIENS	http://www.wikipathways.org/instance/WP61_r78592	7.701952793357797e-8	7.701952793357797e-8	+1	PIK3R1,GATA3,NOTCH1,FBXW7,AKT1,EP300,CCND1,CDKN1A,NCOR1
BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY	BIOCARTA_GSK3_PATHWAY	7.732312634700058e-8	7.732312634700058e-8	+1	PIK3CA,APC,PIK3R1,CTNNB1,AKT1,TLR4,CCND1
POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0010718	positive regulation of epithelial to mesenchymal transition	8.279308239363573e-8	8.279308239363573e-8	+1	NOTCH1,CTNNB1,MTOR,SMAD4,TGFBR2,SMAD2,AXIN2,EZH2
VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION	Validated targets of C-MYC transcriptional repression	8.438196690296595e-8	8.438196690296595e-8	+1	DNMT3A,CEBPA,CDKN1B,BRCA1,EP300,CCND1,SMAD4,CDKN1A,SMAD2
PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY	PID_MYC_REPRESS_PATHWAY	8.438196690296595e-8	8.438196690296595e-8	+1	DNMT3A,CEBPA,CDKN1B,BRCA1,EP300,CCND1,SMAD4,CDKN1A,SMAD2
CELL CYCLE ARREST%GOBP%GO:0007050	cell cycle arrest	8.459722726069308e-8	8.459722726069308e-8	+1	TP53,APC,CDKN2A,RB1,NOTCH1,STK11,ATM,CDKN1B,MTOR,CDKN1A,CDKN2C
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS%MSIGDB_C2%ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	1.1233452081223911e-7	1.1233452081223911e-7	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,BRAF,PTPN11,MAPK8IP1,EGR3
POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING%GOBP%GO:0051897	positive regulation of protein kinase B signaling	1.1233452081223911e-7	1.1233452081223911e-7	+1	PIK3CA,EGFR,PIK3R1,GATA3,PIK3CG,HGF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20190610%WP51%HOMO SAPIENS	http://www.wikipathways.org/instance/WP51_r94816	1.1233452081223911e-7	1.1233452081223911e-7	+1	PIK3CA,APC,KRAS,EGFR,PIK3R1,ARHGAP35,NRAS,BRAF,PIK3CG,PDGFRA,FGFR2,FGFR3
CELL AGING%GOBP%GO:0007569	cell aging	1.1233452081223911e-7	1.1233452081223911e-7	+1	TP53,CDKN2A,NPM1,TBX3,ATM,CHEK2,CDKN1A,ATR
RAS SIGNALING%WIKIPATHWAYS_20190610%WP4223%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4223_r96928	1.131570427244242e-7	1.131570427244242e-7	+1	PIK3CA,KRAS,EGFR,NF1,PIK3R1,FLT3,NRAS,AKT1,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20190610%WP1530%HOMO SAPIENS	http://www.wikipathways.org/instance/WP1530_r103023	1.131570427244242e-7	1.131570427244242e-7	+1	TP53,RB1,ATM,CDKN1B,BRCA1,CHEK2,CCND1,CDKN1A,ATR,SMC1A
BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY	BIOCARTA_ARF_PATHWAY	1.308351059079882e-7	1.308351059079882e-7	+1	TP53,PIK3CA,PIK3R1,CDKN2A,RB1,PIK3CG
RESPONSE TO UV%GOBP%GO:0009411	response to UV	1.308351059079882e-7	1.308351059079882e-7	+1	TP53,EGFR,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY	BIOCARTA_HCMV_PATHWAY	1.308351059079882e-7	1.308351059079882e-7	+1	PIK3CA,PIK3R1,RB1,MAP3K1,AKT1,PIK3CG
ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN	Alpha6Beta4Integrin	1.4606571181629353e-7	1.4606571181629353e-7	+1	PIK3CA,EGFR,PIK3R1,AKT1,AR,PIK3CG,MTOR,PTPN11,SMAD2
ASSOCIATION BETWEEN PHYSICO-CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20190610%WP3680%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3680_r96435	1.4606571181629353e-7	1.4606571181629353e-7	+1	APC,EGFR,CTNNB1,MAP2K4,AKT1,PIK3CG,CDKN1B,ERBB4,CDKN1A
RAC1/PAK1/P38/MMP2 PATHWAY%WIKIPATHWAYS_20190610%WP3303%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3303_r96971	1.6494628663484363e-7	1.6494628663484363e-7	+1	TP53,PIK3CA,KRAS,EGFR,PIK3R1,CTNNB1,NRAS,AKT1,PTPN11
REGULATION OF ERK1 AND ERK2 CASCADE%GOBP%GO:0070372	regulation of ERK1 and ERK2 cascade	1.6555839317686702e-7	1.6555839317686702e-7	+1	PTEN,EGFR,NOTCH1,FBXW7,FLT3,BRAF,ERBB4,TLR4,KIT,PDGFRA,FGFR2,SMAD4,FGFR3,PTPN11
SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.2	Signaling by FGFR3 fusions in cancer	1.7318065947978966e-7	1.7318065947978966e-7	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR3
RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 69%8951936	RUNX3 regulates p14-ARF	1.7318065947978966e-7	1.7318065947978966e-7	+1	KRAS,RUNX1,EP300,CCND1,CBFB
PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY	PID_CDC42_PATHWAY	1.7772306144881782e-7	1.7772306144881782e-7	+1	PIK3CA,APC,PIK3R1,CTNNB1,MAP3K1,CDH1,MAP2K4,BRAF,MTOR
CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS	CDC42 signaling events	1.7772306144881782e-7	1.7772306144881782e-7	+1	PIK3CA,APC,PIK3R1,CTNNB1,MAP3K1,CDH1,MAP2K4,BRAF,MTOR
PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY	PDGFR-beta signaling pathway	1.825295213082213e-7	1.825295213082213e-7	+1	PIK3CA,PTEN,KRAS,PIK3R1,ARHGAP35,NRAS,MAP2K4,BRAF,PIK3CG,PPP2R1A,PTPN11
NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.3	Negative regulation of the PI3K AKT network	1.8457674815392946e-7	1.8457674815392946e-7	+1	PIK3CA,PTEN,EGFR,PIK3R1,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
SYNAPTIC SIGNALING PATHWAYS ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20190610%WP4539%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4539_r103371	2.2126544281938341e-7	2.2126544281938341e-7	+1	PIK3CA,PTEN,KRAS,NF1,PIK3R1,NRAS,AKT1,MTOR
REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 69%5633007	Regulation of TP53 Activity	2.2373320375108246e-7	2.2373320375108246e-7	+1	TP53,CDKN2A,STK11,AKT1,ATM,MTOR,BRCA1,CHEK2,EP300,TAF1,PPP2R1A,ATR
BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY	BIOCARTA_TGFB_PATHWAY	2.391550726775676e-7	2.391550726775676e-7	+1	APC,CDH1,EP300,SMAD4,TGFBR2,SMAD2
E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK	E2F transcription factor network	2.391550726775676e-7	2.391550726775676e-7	+1	CDKN2A,RB1,CEBPA,ATM,CDKN1B,BRCA1,EP300,CDKN1A,CDKN2C
PATHWAYS REGULATING HIPPO SIGNALING%WIKIPATHWAYS_20190610%WP4540%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4540_r103347	2.391550726775676e-7	2.391550726775676e-7	+1	EGFR,CTNNB1,FLT3,CDH1,MTOR,KIT,PDGFRA,FGFR2,FGFR3,SMAD2
PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY	PID_PDGFRB_PATHWAY	2.391550726775676e-7	2.391550726775676e-7	+1	PIK3CA,PTEN,KRAS,PIK3R1,ARHGAP35,NRAS,MAP2K4,BRAF,PIK3CG,PPP2R1A,PTPN11
HALLMARK_E2F_TARGETS%MSIGDB_C2%HALLMARK_E2F_TARGETS	HALLMARK_E2F_TARGETS	2.4779201395944885e-7	2.4779201395944885e-7	+1	TP53,CDKN2A,CTCF,CDKN1B,BRCA1,CHEK2,BRCA2,CDKN1A,SMC1A,SMC3,RAD21,CDKN2C,EZH2
SIGNALING BY FGFR3%REACTOME%R-HSA-5654741.2	Signaling by FGFR3	2.480449870108847e-7	2.480449870108847e-7	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE SIGNALING%GOBP%GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	2.516187745493924e-7	2.516187745493924e-7	+1	PIK3CA,PTEN,EGFR,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY	PID_E2F_PATHWAY	2.574992201692493e-7	2.574992201692493e-7	+1	CDKN2A,RB1,CEBPA,ATM,CDKN1B,BRCA1,EP300,CDKN1A,CDKN2C
ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN	Alpha6Beta4Integrin	2.574992201692493e-7	2.574992201692493e-7	+1	PIK3CA,EGFR,PIK3R1,AKT1,AR,PIK3CG,MTOR,PTPN11,SMAD2
SIGNALING BY PTK6%REACTOME%R-HSA-8848021.2	Signaling by PTK6	2.6895769687126614e-7	2.6895769687126614e-7	+1	KRAS,EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
NEGATIVE REGULATION OF PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0071901	negative regulation of protein serine/threonine kinase activity	2.6895769687126614e-7	2.6895769687126614e-7	+1	PTEN,APC,NF1,CDKN2A,RB1,CEBPA,AKT1,CDKN1B,PPP2R1A,MAPK8IP1
SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006927.3	Signaling by Non-Receptor Tyrosine Kinases	2.6895769687126614e-7	2.6895769687126614e-7	+1	KRAS,EGFR,ARHGAP35,NRAS,AKT1,CDKN1B,LRRK2,CCND1
TGF-BETA SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP366%HOMO SAPIENS	http://www.wikipathways.org/instance/WP366_r90028	3.0031601059609325e-7	3.0031601059609325e-7	+1	TP53,PIK3R1,MAP2K4,AKT1,EP300,CCND1,SMAD4,TGFBR2,CDKN1A,SIN3A,SMAD2
NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION%GOBP%GO:1901988	negative regulation of cell cycle phase transition	3.44430733778797e-7	3.44430733778797e-7	+1	TP53,PTEN,APC,CDKN2A,RB1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
NEGATIVE REGULATION OF CELL GROWTH%GOBP%GO:0030308	negative regulation of cell growth	3.7313104051077783e-7	3.7313104051077783e-7	+1	TP53,CDKN2A,STK11,CDKN1B,WT1,SMAD4,SOX17,CDKN1A,PPP2R1A,ACVR1B,CDKN2C
AGING%GOBP%GO:0007568	aging	3.8785951418908673e-7	3.8785951418908673e-7	+1	TP53,CDKN2A,NPM1,TBX3,ATM,LRRK2,CHEK2,CDKN1A,ATR
HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA/BETA COMPLEX%WIKIPATHWAYS_20190610%WP3657%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3657_r89276	3.982503902902163e-7	3.982503902902163e-7	+1	PTEN,DNMT3A,FLT3,ATM,EP300,SMAD4
REGULATION OF SISTER CHROMATID COHESION%GOBP%GO:0007063	regulation of sister chromatid cohesion	3.982503902902163e-7	3.982503902902163e-7	+1	RB1,CTNNB1,CTCF,ATRX,AXIN2,RAD21
PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY	PID_FGF_PATHWAY	3.982503902902163e-7	3.982503902902163e-7	+1	PIK3CA,PIK3R1,CDH1,AKT1,HGF,FGFR2,FGFR3,PTPN11
BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY	BIOCARTA_ATRBRCA_PATHWAY	3.982503902902163e-7	3.982503902902163e-7	+1	TP53,ATM,BRCA1,CHEK2,BRCA2,ATR
BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY	BIOCARTA_TFF_PATHWAY	3.982503902902163e-7	3.982503902902163e-7	+1	PIK3CA,EGFR,PIK3R1,CTNNB1,AKT1,PIK3CG
SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 69%5654743	Signaling by FGFR4	4.035099736845792e-7	4.035099736845792e-7	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 69%6804757	Regulation of TP53 Degradation	4.035099736845792e-7	4.035099736845792e-7	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
ST_ADRENERGIC%MSIGDB_C2%ST_ADRENERGIC	ST_ADRENERGIC	4.035099736845792e-7	4.035099736845792e-7	+1	PIK3CA,APC,EGFR,PIK3R1,AKT1,BRAF,AR
PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY	PID_BETA_CATENIN_NUC_PATHWAY	4.4660677361962016e-7	4.4660677361962016e-7	+1	APC,CDKN2A,CTNNB1,CDH1,AR,EP300,CCND1,TBL1XR1,AXIN2
REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION	Regulation of nuclear beta catenin signaling and target gene transcription	4.4660677361962016e-7	4.4660677361962016e-7	+1	APC,CDKN2A,CTNNB1,CDH1,AR,EP300,CCND1,TBL1XR1,AXIN2
REPLICATIVE SENESCENCE%GOBP%GO:0090399	replicative senescence	4.574902793358131e-7	4.574902793358131e-7	+1	TP53,CDKN2A,ATM,CHEK2,ATR
REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME DATABASE ID RELEASE 69%6806003	Regulation of TP53 Expression and Degradation	4.783914843690218e-7	4.783914843690218e-7	+1	TP53,CDKN2A,AKT1,ATM,MTOR,CHEK2,PPP2R1A
NEGATIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN KINASE ACTIVITY%GOBP%GO:1904030	negative regulation of cyclin-dependent protein kinase activity	5.049470878557477e-7	5.049470878557477e-7	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B,CDKN1A
BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY	BIOCARTA_HER2_PATHWAY	5.049470878557477e-7	5.049470878557477e-7	+1	PIK3CA,EGFR,PIK3R1,PIK3CG,ERBB4,EP300
CELLULAR RESPONSE TO ABIOTIC STIMULUS%GOBP%GO:0071214	cellular response to abiotic stimulus	5.812214458430051e-7	5.812214458430051e-7	+1	TP53,PTEN,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
CELLULAR RESPONSE TO ENVIRONMENTAL STIMULUS%GOBP%GO:0104004	cellular response to environmental stimulus	5.812214458430051e-7	5.812214458430051e-7	+1	TP53,PTEN,MAP3K1,NPM1,MAP2K4,STK11,SOX9,ATM,TLR4,EP300,CDKN1A,TAF1,ATR
PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY	PID_P53_REGULATION_PATHWAY	6.282299678206473e-7	6.282299678206473e-7	+1	TP53,CDKN2A,AKT1,ATM,CHEK2,EP300,ATR,RPL5
P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY	p53 pathway	6.282299678206473e-7	6.282299678206473e-7	+1	TP53,CDKN2A,AKT1,ATM,CHEK2,EP300,ATR,RPL5
BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY	BIOCARTA_P53HYPOXIA_PATHWAY	6.332412613110253e-7	6.332412613110253e-7	+1	TP53,AKT1,ATM,EP300,CDKN1A,TAF1
BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY	BIOCARTA_MTOR_PATHWAY	6.332412613110253e-7	6.332412613110253e-7	+1	PIK3CA,PTEN,PIK3R1,AKT1,MTOR,EIF4A2
REGULATION OF DNA REPLICATION%GOBP%GO:0006275	regulation of DNA replication	6.332412613110253e-7	6.332412613110253e-7	+1	EGFR,FBXW7,STAG2,ATRX,CHEK2,PPP2R1A,ATR,SMC1A,SMC3
BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY	BIOCARTA_CELLCYCLE_PATHWAY	6.332412613110253e-7	6.332412613110253e-7	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,CDKN2C
BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY	BIOCARTA_GLEEVEC_PATHWAY	6.332412613110253e-7	6.332412613110253e-7	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG
ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 69%9018519	Estrogen-dependent gene expression	7.377323833495204e-7	7.377323833495204e-7	+1	GATA3,RUNX1,STAG2,FOXA1,EP300,CCND1,CBFB,HIST1H2BD,SMC1A,SMC3,RAD21
PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY	PID_IFNG_PATHWAY	7.685171747279622e-7	7.685171747279622e-7	+1	PIK3CA,PIK3R1,MAP3K1,AKT1,MTOR,EP300,PTPN11
BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY	BIOCARTA_EIF4_PATHWAY	8.206001546232473e-7	8.206001546232473e-7	+1	PIK3CA,PTEN,PIK3R1,AKT1,MTOR,EIF4A2
REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING%GOBP%GO:2000677	regulation of transcription regulatory region DNA binding	9.009278524335804e-7	9.009278524335804e-7	+1	GATA3,RB1,CTNNB1,EP300,TAF1,SIN3A,NSD1
ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS	ErbB2 ErbB3 signaling events	9.009278524335804e-7	9.009278524335804e-7	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,MTOR,PTPN11
PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.2	PI5P, PP2A and IER3 Regulate PI3K AKT Signaling	9.97865565804889e-7	9.97865565804889e-7	+1	PIK3CA,EGFR,PIK3R1,AKT1,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 69%5654736	Signaling by FGFR1	0.000001058947602693083	0.000001058947602693083	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
NEGATIVE REGULATION OF MITOTIC CELL CYCLE PHASE TRANSITION%GOBP%GO:1901991	negative regulation of mitotic cell cycle phase transition	0.0000010846316365891988	0.0000010846316365891988	+1	TP53,PTEN,APC,CDKN2A,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A,CDKN2C
G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20190610%WP45%HOMO SAPIENS	http://www.wikipathways.org/instance/WP45_r102300	0.0000010951679659238218	0.0000010951679659238218	+1	TP53,CDKN2A,RB1,ATM,CDKN1B,CCND1,CDKN1A,CDKN2C
CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME%R-HSA-69231.6	Cyclin D associated events in G1	0.0000012070518617201457	0.0000012070518617201457	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN	Regulation of retinoblastoma protein	0.0000012070518617201457	0.0000012070518617201457	+1	CDKN2A,RB1,CEBPA,CDKN1B,EP300,CCND1,CDKN1A,TAF1
G1 PHASE%REACTOME%R-HSA-69236.4	G1 Phase	0.0000012070518617201457	0.0000012070518617201457	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY	IFN-gamma pathway	0.0000012070518617201457	0.0000012070518617201457	+1	PIK3CA,PIK3R1,MAP3K1,AKT1,MTOR,EP300,PTPN11
WNT/BETA-CATENIN SIGNALING PATHWAY IN LEUKEMIA%WIKIPATHWAYS_20190610%WP3658%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3658_r97640	0.0000012829203762775755	0.0000012829203762775755	+1	APC,CTNNB1,FLT3,AKT1,CCND1,AXIN2
ONCOSTATIN M SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP2374%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2374_r98073	0.0000013197865323935348	0.0000013197865323935348	+1	TP53,KRAS,PIK3R1,AKT1,CDKN1B,MTOR,PTPN11,LIFR
FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.2	FOXO-mediated transcription	0.0000013197865323935348	0.0000013197865323935348	+1	STK11,AKT1,CDKN1B,EP300,SMAD4,CDKN1A,SIN3A,SMAD2
PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY	PID_RB_1PATHWAY	0.0000013197865323935348	0.0000013197865323935348	+1	CDKN2A,RB1,CEBPA,CDKN1B,EP300,CCND1,CDKN1A,TAF1
REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	0.0000013197865323935348	0.0000013197865323935348	+1	RUNX1,CRIPAK,BRCA1,FOXA1,EP300,TAF1,CBFB,NCOR1
PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY	PID_ERBB2_ERBB3_PATHWAY	0.0000013684676009221916	0.0000013684676009221916	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,MTOR,PTPN11
REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE	Regulation of Telomerase	0.0000014697298102893346	0.0000014697298102893346	+1	EGFR,AKT1,ATM,CDKN1B,WT1,MTOR,CCND1,SIN3A
CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME%R-HSA-5637810.1	Constitutive Signaling by EGFRvIII	0.0000015216439307416825	0.0000015216439307416825	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.1	Signaling by EGFRvIII in Cancer	0.0000015216439307416825	0.0000015216439307416825	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 69%186763	Downstream signal transduction	0.000001545063424488751	0.000001545063424488751	+1	PIK3CA,KRAS,PIK3R1,NRAS,PDGFRA,PTPN11
PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY	PID_TELOMERASE_PATHWAY	0.0000016029020848338407	0.0000016029020848338407	+1	EGFR,AKT1,ATM,CDKN1B,WT1,MTOR,CCND1,SIN3A
AMP-ACTIVATED PROTEIN KINASE (AMPK) SIGNALING%WIKIPATHWAYS_20190610%WP1403%HOMO SAPIENS	http://www.wikipathways.org/instance/WP1403_r98156	0.0000016029020848338407	0.0000016029020848338407	+1	TP53,PIK3CA,PIK3R1,STK11,AKT1,PIK3CG,MTOR,CDKN1A
VASCULATURE DEVELOPMENT%GOBP%GO:0001944	vasculature development	0.000001660202090990447	0.000001660202090990447	+1	PIK3CA,NF1,NOTCH1,FBXW7,CTNNB1,STK11,AKT1,WT1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
RESPONSE TO LIGHT STIMULUS%GOBP%GO:0009416	response to light stimulus	0.000001771685561742284	0.000001771685561742284	+1	TP53,EGFR,NF1,NPM1,STK11,AKT1,EP300,CCND1,CDKN1A,TAF1,ATR,ERCC2
FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY	FGF signaling pathway	0.0000017821698283603876	0.0000017821698283603876	+1	PIK3CA,PIK3R1,CDH1,AKT1,FGFR2,FGFR3,PTPN11
PROTEIN STABILIZATION%GOBP%GO:0050821	protein stabilization	0.0000018827438812444059	0.0000018827438812444059	+1	PTEN,VHL,PIK3R1,FBXW7,CHEK2,EP300,USP9X,SOX17,CDKN1A,TAF1,RPL5
PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY	PID_AP1_PATHWAY	0.0000019124810745333416	0.0000019124810745333416	+1	TP53,PTEN,CDKN2A,CTNNB1,CDKN1B,EP300,CCND1,CBFB
RAS PATHWAY%PANTHER PATHWAY%P04393	Ras Pathway	0.0000019124810745333416	0.0000019124810745333416	+1	PIK3CA,KRAS,MAP3K1,NRAS,MAP2K4,AKT1,BRAF,PIK3CG
AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK	AP-1 transcription factor network	0.0000019124810745333416	0.0000019124810745333416	+1	TP53,PTEN,CDKN2A,CTNNB1,CDKN1B,EP300,CCND1,CBFB
PEPTIDYL-TYROSINE PHOSPHORYLATION%GOBP%GO:0018108	peptidyl-tyrosine phosphorylation	0.0000019124810745333416	0.0000019124810745333416	+1	EGFR,FLT3,EPHA3,ERBB4,KIT,PDGFRA,FGFR2,FGFR3
PATTERN SPECIFICATION PROCESS%GOBP%GO:0007389	pattern specification process	0.0000019124810745333416	0.0000019124810745333416	+1	APC,NOTCH1,TBX3,WT1,ERBB4,FGFR2,FOXA2,TGFBR2,SOX17,ACVR1B,ACVR2A,SMAD2
NEGATIVE REGULATION OF DNA METABOLIC PROCESS%GOBP%GO:0051053	negative regulation of DNA metabolic process	0.000001922310683476185	0.000001922310683476185	+1	TP53,FBXW7,STAG2,ATM,POLQ,CHEK2,HIST1H1C,ATR,SMC1A,SMC3
SA_G1_AND_S_PHASES%MSIGDB_C2%SA_G1_AND_S_PHASES	SA_G1_AND_S_PHASES	0.000002081478500998219	0.000002081478500998219	+1	TP53,CDKN2A,CDKN1B,CCND1,CDKN1A
TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20190610%WP4566%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4566_r104315	0.0000022928719458520146	0.0000022928719458520146	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PIK3CG,MTOR,EIF4A2
POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE SIGNALING%GOBP%GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	0.000002324382899796584	0.000002324382899796584	+1	PIK3CA,PIK3R1,FLT3,PIK3CG,SOX9,HGF,KIT,PDGFRA
EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 69%9009391	Extra-nuclear estrogen signaling	0.000002324382899796584	0.000002324382899796584	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,AKT1,CDKN1B,CCND1
POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE%GOBP%GO:0070374	positive regulation of ERK1 and ERK2 cascade	0.00000254321290420914	0.00000254321290420914	+1	EGFR,NOTCH1,FBXW7,FLT3,BRAF,ERBB4,KIT,PDGFRA,FGFR2,FGFR3,PTPN11
REGULATION OF SISTER CHROMATID SEGREGATION%GOBP%GO:0033045	regulation of sister chromatid segregation	0.0000025494074146827324	0.0000025494074146827324	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,AXIN2,RAD21
PEPTIDYL-TYROSINE MODIFICATION%GOBP%GO:0018212	peptidyl-tyrosine modification	0.0000025494074146827324	0.0000025494074146827324	+1	EGFR,FLT3,EPHA3,ERBB4,KIT,PDGFRA,FGFR2,FGFR3
BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY	BIOCARTA_BCELLSURVIVAL_PATHWAY	0.000002873561132911067	0.000002873561132911067	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,MTOR
BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY	BIOCARTA_P53_PATHWAY	0.000002873561132911067	0.000002873561132911067	+1	TP53,RB1,ATM,CCND1,CDKN1A
HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20190610%WP3646%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3646_r103011	0.00000293351516137262	0.00000293351516137262	+1	TP53,AKT1,BRCA1,CCND1,SMAD4,CDKN1A,PTPN11
DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0030330	DNA damage response, signal transduction by p53 class mediator	0.0000030883830819986293	0.0000030883830819986293	+1	TP53,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A
CELL CYCLE CHECKPOINT%GOBP%GO:0000075	cell cycle checkpoint	0.0000030954297553363234	0.0000030954297553363234	+1	TP53,APC,RB1,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
NEGATIVE REGULATION OF DNA ENDOREDUPLICATION%GOBP%GO:0032876	negative regulation of DNA endoreduplication	0.000003144154265167483	0.000003144154265167483	+1	FBXW7,STAG2,SMC1A,SMC3
PHOSPHATIDYLINOSITOL 3-KINASE SIGNALING%GOBP%GO:0014065	phosphatidylinositol 3-kinase signaling	0.000003214360559906914	0.000003214360559906914	+1	PIK3CA,NF1,PIK3R1,GATA3,AKT1,PIK3CG
WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20190610%WP399%HOMO SAPIENS	http://www.wikipathways.org/instance/WP399_r94890	0.0000032349062174547196	0.0000032349062174547196	+1	TP53,APC,CTNNB1,MAP2K4,LRRK2,EP300,CCND1,PPP2R1A,AXIN2
POSITIVE REGULATION OF ANIMAL ORGAN MORPHOGENESIS%GOBP%GO:0110110	positive regulation of animal organ morphogenesis	0.0000032688568957591183	0.0000032688568957591183	+1	GATA3,NOTCH1,SOX9,WT1,FGFR2,SMAD4,TGFBR2
SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20190610%WP615%HOMO SAPIENS	http://www.wikipathways.org/instance/WP615_r98554	0.000003474384984551152	0.000003474384984551152	+1	TP53,PTEN,CDKN2A,RB1,BRAF,CDKN1B,MTOR,SMAD4,CDKN1A
SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0072331	signal transduction by p53 class mediator	0.000003748730793388926	0.000003748730793388926	+1	TP53,STK11,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A
TIE2 SIGNALING%REACTOME%R-HSA-210993.1	Tie2 Signaling	0.0000037900693127062374	0.0000037900693127062374	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY	BIOCARTA_PDGF_PATHWAY	0.0000037900693127062374	0.0000037900693127062374	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,PIK3CG,PDGFRA
EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY	EGF receptor (ErbB1) signaling pathway	0.0000037900693127062374	0.0000037900693127062374	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,PTPN11
BDNF-TRKB SIGNALING%WIKIPATHWAYS_20190610%WP3676%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3676_r94186	0.000004574268988754752	0.000004574268988754752	+1	KRAS,NRAS,AKT1,BRAF,PIK3CG,MTOR
ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20190610%WP2853%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2853_r88152	0.000004748257194283884	0.000004748257194283884	+1	APC,NOTCH1,CTNNB1,FOXA1,SMAD4,FOXA2,SOX17,PHF6,SMAD2,EZH2
PROTEIN-DNA COMPLEX SUBUNIT ORGANIZATION%GOBP%GO:0071824	protein-DNA complex subunit organization	0.000004773513924468261	0.000004773513924468261	+1	TP53,ARID1A,PBRM1,CTCF,NPM1,SOX9,ATRX,HIST1H1C,SETD2,TAF1,HIST1H2BD,ERCC2
SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 69%5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.000004979317339983321	0.000004979317339983321	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
SIGNALING BY FGFR3 POINT MUTANTS IN CANCER%REACTOME%R-HSA-8853338.2	Signaling by FGFR3 point mutants in cancer	0.000004979317339983321	0.000004979317339983321	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR3
BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY	BIOCARTA_PTEN_PATHWAY	0.000004979317339983321	0.000004979317339983321	+1	PIK3CA,PTEN,PIK3R1,AKT1,CDKN1B
CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.1	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.000004979317339983321	0.000004979317339983321	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
SIGNALING BY FGFR3 IN DISEASE%REACTOME%R-HSA-5655332.3	Signaling by FGFR3 in disease	0.000004979317339983321	0.000004979317339983321	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR3
BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY	BIOCARTA_TEL_PATHWAY	0.000004979317339983321	0.000004979317339983321	+1	TP53,KRAS,EGFR,RB1,AKT1
IL-4 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP395%HOMO SAPIENS	http://www.wikipathways.org/instance/WP395_r89828	0.000005165357051629008	0.000005165357051629008	+1	PIK3CA,PIK3R1,GATA3,CEBPA,AKT1,EP300,PTPN11
NEGATIVE REGULATION OF DNA REPLICATION%GOBP%GO:0008156	negative regulation of DNA replication	0.000005244710480023544	0.000005244710480023544	+1	FBXW7,STAG2,CHEK2,ATR,SMC1A,SMC3
ST_INTEGRIN_SIGNALING_PATHWAY%MSIGDB_C2%ST_INTEGRIN_SIGNALING_PATHWAY	ST_INTEGRIN_SIGNALING_PATHWAY	0.000005556350023756725	0.000005556350023756725	+1	PIK3CA,PTEN,CDKN2A,ARHGAP35,MAP2K4,AKT1,BRAF,MAPK8IP1
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	0.000006227782437015846	0.000006227782437015846	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,PTPN11
EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018	EGF receptor signaling pathway	0.000006398202040623002	0.000006398202040623002	+1	PIK3CA,EGFR,NF1,NRAS,MAP2K4,AKT1,BRAF,PIK3CG,ERBB4
SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING	SHP2 signaling	0.000006456117397661691	0.000006456117397661691	+1	PIK3CA,KRAS,EGFR,PIK3R1,ARHGAP35,NRAS,PTPN11
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-HSA-5654708.1	Downstream signaling of activated FGFR3	0.000006456117397661691	0.000006456117397661691	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
NEGATIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	0.000006456117397661691	0.000006456117397661691	+1	PTEN,APC,CDKN2A,CEBPA,CDKN1B
CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 69%2559583	Cellular Senescence	0.000007037870984917501	0.000007037870984917501	+1	TP53,CDKN2A,RB1,MAP2K4,ATM,CDKN1B,HIST1H1C,CDKN1A,HIST1H2BD,CDKN2C,EZH2
MEIOSIS%REACTOME%R-HSA-1500620.2	Meiosis	0.000007037870984917501	0.000007037870984917501	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA	Trk receptor signaling mediated by PI3K and PLC-gamma	0.000007037870984917501	0.000007037870984917501	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,CCND1
CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING	CD40 CD40L signaling	0.000007037870984917501	0.000007037870984917501	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG
PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY	PID_SHP2_PATHWAY	0.000007037870984917501	0.000007037870984917501	+1	PIK3CA,KRAS,EGFR,PIK3R1,ARHGAP35,NRAS,PTPN11
NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY	Notch signaling pathway	0.000007037870984917501	0.000007037870984917501	+1	GATA3,NOTCH1,FBXW7,EP300,CCND1,CDKN1A,NCOR1
E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION	E-cadherin signaling in the nascent adherens junction	0.000007037870984917501	0.000007037870984917501	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,AKT1,CCND1
PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY	PID_PI3K_PLC_TRK_PATHWAY	0.000007037870984917501	0.000007037870984917501	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,CCND1
TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 69%8878166	Transcriptional regulation by RUNX2	0.000007534583424219871	0.000007534583424219871	+1	RB1,RUNX1,AKT1,AR,SOX9,CCND1,SMAD4,CDKN1A,CBFB
PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY	PID_ATF2_PATHWAY	0.000007724046751313857	0.000007724046751313857	+1	NF1,RB1,BRCA1,PDGFRA,EP300,CCND1,CBFB
PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY	PID_NOTCH_PATHWAY	0.000007724046751313857	0.000007724046751313857	+1	GATA3,NOTCH1,FBXW7,EP300,CCND1,CDKN1A,NCOR1
ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK	ATF-2 transcription factor network	0.000007724046751313857	0.000007724046751313857	+1	NF1,RB1,BRCA1,PDGFRA,EP300,CCND1,CBFB
CHROMATIN ASSEMBLY OR DISASSEMBLY%GOBP%GO:0006333	chromatin assembly or disassembly	0.000007724046751313857	0.000007724046751313857	+1	TP53,ARID1A,PBRM1,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD
BMP SIGNALING PATHWAY IN EYELID DEVELOPMENT%WIKIPATHWAYS_20190610%WP3927%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3927_r90735	0.00000794089214950283	0.00000794089214950283	+1	EGFR,NOTCH1,MAP3K1,FGFR2,SMAD4
BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY	BIOCARTA_ATM_PATHWAY	0.00000794089214950283	0.00000794089214950283	+1	TP53,ATM,BRCA1,CHEK2,CDKN1A
BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY	BIOCARTA_IGF1MTOR_PATHWAY	0.00000794089214950283	0.00000794089214950283	+1	PIK3CA,PTEN,PIK3R1,AKT1,MTOR
BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY	BIOCARTA_MET_PATHWAY	0.00000794607381548679	0.00000794607381548679	+1	PIK3CA,PTEN,PIK3R1,PIK3CG,HGF,PTPN11
SISTER CHROMATID COHESION%GOBP%GO:0007062	sister chromatid cohesion	0.00000794607381548679	0.00000794607381548679	+1	RB1,FBXW7,STAG2,SMC1A,SMC3,RAD21
DNA DAMAGE CHECKPOINT%GOBP%GO:0000077	DNA damage checkpoint	0.000008313285246144123	0.000008313285246144123	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20190610%WP2446%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2446_r102997	0.00000857733904451822	0.00000857733904451822	+1	TP53,RB1,CDKN1B,CCND1,CDKN1A,SIN3A,SMC1A,SMC3
ANOIKIS%GOBP%GO:0043276	anoikis	0.000008887824297155869	0.000008887824297155869	+1	PIK3CA,STK11,AKT1,MTOR
REGULATION OF DNA ENDOREDUPLICATION%GOBP%GO:0032875	regulation of DNA endoreduplication	0.000008887824297155869	0.000008887824297155869	+1	FBXW7,STAG2,SMC1A,SMC3
CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS	CXCR3-mediated signaling events	0.000009172409088778973	0.000009172409088778973	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,MTOR
FOCAL ADHESION%WIKIPATHWAYS_20190610%WP306%HOMO SAPIENS	http://www.wikipathways.org/instance/WP306_r97459	0.000009245193313799346	0.000009245193313799346	+1	PIK3CA,PTEN,EGFR,PIK3R1,CTNNB1,ARHGAP35,AKT1,BRAF,HGF,PDGFRA,CCND1
T CELL ACTIVATION%PANTHER PATHWAY%P00053	T cell activation	0.000009245193313799346	0.000009245193313799346	+1	PIK3CA,PIK3R1,MAP3K1,NRAS,AKT1,BRAF,PIK3CG
CHROMATIN REMODELING%GOBP%GO:0006338	chromatin remodeling	0.000009245193313799346	0.000009245193313799346	+1	ARID1A,PBRM1,CDKN2A,RB1,NPM1,KDM6A,SOX9,KDM5C,ATRX,FOXA1
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME%R-HSA-2219530.1	Constitutive Signaling by Aberrant PI3K in Cancer	0.000010099388262026502	0.000010099388262026502	+1	PIK3CA,EGFR,PIK3R1,HGF,KIT,PDGFRA,PTPN11
PHOSPHATIDYLINOSITOL-MEDIATED SIGNALING%GOBP%GO:0048015	phosphatidylinositol-mediated signaling	0.000010099388262026502	0.000010099388262026502	+1	PIK3CA,NF1,PIK3R1,GATA3,AKT1,PIK3CG,PDGFRA
MITOTIC G1/S TRANSITION CHECKPOINT%GOBP%GO:0044819	mitotic G1/S transition checkpoint	0.000010099388262026502	0.000010099388262026502	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
MITOTIC G1 DNA DAMAGE CHECKPOINT%GOBP%GO:0031571	mitotic G1 DNA damage checkpoint	0.000010099388262026502	0.000010099388262026502	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY	PID_ECADHERIN_NASCENT_AJ_PATHWAY	0.000010365894015919007	0.000010365894015919007	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,AKT1,CCND1
SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 69%1433557	Signaling by SCF-KIT	0.000010365894015919007	0.000010365894015919007	+1	PIK3CA,KRAS,PIK3R1,NRAS,KIT,PTPN11
G1 DNA DAMAGE CHECKPOINT%GOBP%GO:0044783	G1 DNA damage checkpoint	0.000011101697145091915	0.000011101697145091915	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
INOSITOL LIPID-MEDIATED SIGNALING%GOBP%GO:0048017	inositol lipid-mediated signaling	0.000011101697145091915	0.000011101697145091915	+1	PIK3CA,NF1,PIK3R1,GATA3,AKT1,PIK3CG,PDGFRA
PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY	PID_FOXM1_PATHWAY	0.000011773175128838854	0.000011773175128838854	+1	CDKN2A,RB1,CHEK2,EP300,CCND1,BRCA2
TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER%GOBP%GO:0006367	transcription initiation from RNA polymerase II promoter	0.000011773175128838854	0.000011773175128838854	+1	TP53,PTEN,NOTCH1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
MAMMARY GLAND DEVELOPMENT%GOBP%GO:0030879	mammary gland development	0.000011773175128838854	0.000011773175128838854	+1	ARHGAP35,TBX3,AKT1,ERBB4,ELF3,FGFR2
ATM SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP2516%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2516_r102220	0.000011773175128838854	0.000011773175128838854	+1	TP53,ATM,BRCA1,CHEK2,CDKN1A,SMC1A
IRS-MEDIATED SIGNALLING%REACTOME%R-HSA-112399.3	IRS-mediated signalling	0.000011773175128838854	0.000011773175128838854	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,PTPN11
SIGNALING BY NTRK2 (TRKB)%REACTOME%R-HSA-9006115.2	Signaling by NTRK2 (TRKB)	0.000012026482625863524	0.000012026482625863524	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
ERBB SIGNALING PATHWAY%GOBP%GO:0038127	ERBB signaling pathway	0.000013401907544975737	0.000013401907544975737	+1	PIK3CA,EGFR,PIK3R1,AKT1,SOX9,ERBB4,PTPN11
SIGNALING BY FGFR4 IN DISEASE%REACTOME DATABASE ID RELEASE 69%5655291	Signaling by FGFR4 in disease	0.000013487053307194193	0.000013487053307194193	+1	PIK3CA,KRAS,PIK3R1,NRAS
COHESIN LOADING ONTO CHROMATIN%REACTOME%R-HSA-2470946.1	Cohesin Loading onto Chromatin	0.000013487053307194193	0.000013487053307194193	+1	STAG2,SMC1A,SMC3,RAD21
REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:1901796	regulation of signal transduction by p53 class mediator	0.000013487542552777045	0.000013487542552777045	+1	TP53,STK11,AKT1,ATM,BRCA1,CHEK2,EP300,TAF1,ATR,RPL5
CELLULAR RESPONSE TO EXTERNAL STIMULUS%GOBP%GO:0071496	cellular response to external stimulus	0.000013884579457502964	0.000013884579457502964	+1	TP53,MAP3K1,ARHGAP35,MAP2K4,SOX9,MTOR,TLR4,LRRK2,FOXA2,CDKN1A,TAF1
REGULATION OF CHROMOSOME SEGREGATION%GOBP%GO:0051983	regulation of chromosome segregation	0.000013908901508199593	0.000013908901508199593	+1	APC,RB1,CTNNB1,CTCF,ATM,ATRX,AXIN2,RAD21
SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 69%5654738	Signaling by FGFR2	0.00001454411916626829	0.00001454411916626829	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
NEGATIVE REGULATION OF DNA-DEPENDENT DNA REPLICATION%GOBP%GO:2000104	negative regulation of DNA-dependent DNA replication	0.000014677513219293613	0.000014677513219293613	+1	FBXW7,STAG2,CHEK2,SMC1A,SMC3
BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY	BIOCARTA_RAC1_PATHWAY	0.000014677513219293613	0.000014677513219293613	+1	PIK3CA,PIK3R1,MAP3K1,PIK3CG,PDGFRA
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 69%5654716	Downstream signaling of activated FGFR4	0.000014677513219293613	0.000014677513219293613	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK	FOXM1 transcription factor network	0.00001514810238509568	0.00001514810238509568	+1	CDKN2A,RB1,CHEK2,EP300,CCND1,BRCA2
REGULATION OF ANIMAL ORGAN MORPHOGENESIS%GOBP%GO:2000027	regulation of animal organ morphogenesis	0.000015391899005910502	0.000015391899005910502	+1	GATA3,NOTCH1,FBXW7,CTNNB1,SOX9,WT1,HGF,FGFR2,SMAD4,TGFBR2
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	0.000015764580207439866	0.000015764580207439866	+1	PIK3CA,PTEN,CDKN2A,AKT1,CDKN1B,ERBB4,MTOR
SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE%GOBP%GO:0042770	signal transduction in response to DNA damage	0.00001582429603732314	0.00001582429603732314	+1	TP53,ATM,CDKN1B,ATRX,BRCA1,CHEK2,EP300,CDKN1A
DNA INTEGRITY CHECKPOINT%GOBP%GO:0031570	DNA integrity checkpoint	0.000016093778283001336	0.000016093778283001336	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A,ATR
CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS	Class I PI3K signaling events	0.000016840443660217967	0.000016840443660217967	+1	PIK3CA,PTEN,KRAS,PIK3R1,NRAS,PIK3CG
MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20190610%WP1544%HOMO SAPIENS	http://www.wikipathways.org/instance/WP1544_r102988	0.000016840443660217967	0.000016840443660217967	+1	PIK3CA,PIK3R1,CTNNB1,MAP2K4,AKT1,PIK3CG,MTOR,FGFR2
REPRODUCTIVE SYSTEM DEVELOPMENT%GOBP%GO:0061458	reproductive system development	0.000016840443660217967	0.000016840443660217967	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY	PID_CXCR3_PATHWAY	0.000016840443660217967	0.000016840443660217967	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,MTOR
REPRODUCTIVE STRUCTURE DEVELOPMENT%GOBP%GO:0048608	reproductive structure development	0.000016840443660217967	0.000016840443660217967	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,FGFR2,PTPN11
SEX DIFFERENTIATION%GOBP%GO:0007548	sex differentiation	0.000016840443660217967	0.000016840443660217967	+1	GATA3,TBX3,AR,SOX9,WT1,KIT,PDGFRA,PTPN11
HUMAN THYROID STIMULATING HORMONE (TSH) SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP2032%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2032_r89823	0.000016876942412524587	0.000016876942412524587	+1	PIK3CA,PIK3R1,RB1,AKT1,BRAF,CDKN1B,MTOR
SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 69%1643713	Signaling by EGFR in Cancer	0.00001734505310019014	0.00001734505310019014	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.2	Signaling by Erythropoietin	0.00001734505310019014	0.00001734505310019014	+1	PIK3CA,KRAS,PIK3R1,NRAS,PIK3CG
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 69%5654687	Downstream signaling of activated FGFR1	0.00001734505310019014	0.00001734505310019014	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME%R-HSA-5654696.1	Downstream signaling of activated FGFR2	0.00001734505310019014	0.00001734505310019014	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 69%2428924	IGF1R signaling cascade	0.000018746556943154392	0.000018746556943154392	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,PTPN11
IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 69%2428928	IRS-related events triggered by IGF1R	0.000018746556943154392	0.000018746556943154392	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,PTPN11
FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK	FOXA1 transcription factor network	0.000018746556943154392	0.000018746556943154392	+1	AR,CDKN1B,BRCA1,FOXA1,EP300,FOXA2
PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY	PID_HNF3A_PATHWAY	0.000018746556943154392	0.000018746556943154392	+1	AR,CDKN1B,BRCA1,FOXA1,EP300,FOXA2
ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 69%2468052	Establishment of Sister Chromatid Cohesion	0.000018944574171874732	0.000018944574171874732	+1	STAG2,SMC1A,SMC3,RAD21
SIGNAL TRANSDUCTION INVOLVED IN DNA INTEGRITY CHECKPOINT%GOBP%GO:0072401	signal transduction involved in DNA integrity checkpoint	0.000019723204971079203	0.000019723204971079203	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
SIGNAL TRANSDUCTION INVOLVED IN DNA DAMAGE CHECKPOINT%GOBP%GO:0072422	signal transduction involved in DNA damage checkpoint	0.000019723204971079203	0.000019723204971079203	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
CELLULAR RESPONSE TO UV%GOBP%GO:0034644	cellular response to UV	0.000019723204971079203	0.000019723204971079203	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY	PID_P53_DOWNSTREAM_PATHWAY	0.000020437905264565798	0.000020437905264565798	+1	TP53,PTEN,APC,EGFR,RB1,HGF,FOXA1,EP300,CDKN1A
EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0007173	epidermal growth factor receptor signaling pathway	0.00002089048110264232	0.00002089048110264232	+1	PIK3CA,EGFR,PIK3R1,AKT1,SOX9,PTPN11
REGULATION OF LIPID KINASE ACTIVITY%GOBP%GO:0043550	regulation of lipid kinase activity	0.00002089048110264232	0.00002089048110264232	+1	PIK3R1,RB1,FLT3,KIT,PDGFRA,FGFR3
SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME DATABASE ID RELEASE 69%2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.00002089048110264232	0.00002089048110264232	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,PTPN11
REGULATION OF CELL CYCLE ARREST%GOBP%GO:0071156	regulation of cell cycle arrest	0.000021215530075975653	0.000021215530075975653	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CCND1,CDKN1A
SIGNAL TRANSDUCTION INVOLVED IN CELL CYCLE CHECKPOINT%GOBP%GO:0072395	signal transduction involved in cell cycle checkpoint	0.000021285896308450034	0.000021285896308450034	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
ATM SIGNALING NETWORK IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20190610%WP3878%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3878_r89745	0.000023460511912282304	0.000023460511912282304	+1	STK11,ATM,MTOR,CHEK2,ATR,SMC1A
HEART VALVE MORPHOGENESIS%GOBP%GO:0003179	heart valve morphogenesis	0.000023460511912282304	0.000023460511912282304	+1	GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2
INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 69%74751	Insulin receptor signalling cascade	0.000023460511912282304	0.000023460511912282304	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,PTPN11
MITOTIC CELL CYCLE CHECKPOINT%GOBP%GO:0007093	mitotic cell cycle checkpoint	0.000023743574231690094	0.000023743574231690094	+1	TP53,APC,RB1,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021	FGF signaling pathway	0.0000240932462944134	0.0000240932462944134	+1	PIK3CA,NRAS,MAP2K4,AKT1,PIK3CG,FGFR2,FGFR3,PPP2R1A
BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY	BIOCARTA_BAD_PATHWAY	0.000024701642878515172	0.000024701642878515172	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,KIT
DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS	Direct p53 effectors	0.000024941106073827365	0.000024941106073827365	+1	TP53,PTEN,APC,EGFR,RB1,HGF,FOXA1,EP300,CDKN1A
PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY	PID_DELTA_NP63_PATHWAY	0.000025832878338609438	0.000025832878338609438	+1	CDKN2A,NOTCH1,FBXW7,RUNX1,ATM,BRCA2
SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 69%1227986	Signaling by ERBB2	0.000025832878338609438	0.000025832878338609438	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,AKT1
VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS	Validated transcriptional targets of deltaNp63 isoforms	0.000025832878338609438	0.000025832878338609438	+1	CDKN2A,NOTCH1,FBXW7,RUNX1,ATM,BRCA2
REGULATION OF DNA-DEPENDENT DNA REPLICATION%GOBP%GO:0090329	regulation of DNA-dependent DNA replication	0.000025832878338609438	0.000025832878338609438	+1	FBXW7,STAG2,ATRX,CHEK2,SMC1A,SMC3
NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK	Notch-mediated HES HEY network	0.000025832878338609438	0.000025832878338609438	+1	RB1,NOTCH1,AR,CDKN1B,EP300,NCOR1
REGULATION OF OXIDATIVE STRESS-INDUCED CELL DEATH%GOBP%GO:1903201	regulation of oxidative stress-induced cell death	0.000025832878338609438	0.000025832878338609438	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
MESENCHYME DEVELOPMENT%GOBP%GO:0060485	mesenchyme development	0.00002721736310161493	0.00002721736310161493	+1	NOTCH1,CTNNB1,SOX9,WT1,HGF,ERBB4,FGFR2,TGFBR2,SMAD2
REPRODUCTION%REACTOME DATABASE ID RELEASE 69%1474165	Reproduction	0.00002721736310161493	0.00002721736310161493	+1	STAG2,ATM,BRCA1,BRCA2,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
POSITIVE REGULATION OF DNA-BINDING TRANSCRIPTION FACTOR ACTIVITY%GOBP%GO:0051091	positive regulation of DNA-binding transcription factor activity	0.00002721736310161493	0.00002721736310161493	+1	PTEN,CTNNB1,NPM1,AKT1,AR,TLR4,ARID5B,FOXA1,KIT,EP300,TAF1
REGULATION OF CENTROMERIC SISTER CHROMATID COHESION%GOBP%GO:0070602	regulation of centromeric sister chromatid cohesion	0.000028570324495797677	0.000028570324495797677	+1	CTNNB1,CTCF,AXIN2
RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 69%6802953	RAS signaling downstream of NF1 loss-of-function variants	0.000028570324495797677	0.000028570324495797677	+1	KRAS,NF1,NRAS
SIGNALING BY EGFR%REACTOME%R-HSA-177929.1	Signaling by EGFR	0.000028660245280948865	0.000028660245280948865	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,PTPN11
PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY	PID_HES_HEY_PATHWAY	0.000028660245280948865	0.000028660245280948865	+1	RB1,NOTCH1,AR,CDKN1B,EP300,NCOR1
BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY	BIOCARTA_EDG1_PATHWAY	0.000028660245280948865	0.000028660245280948865	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,PDGFRA
SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 69%157118	Signaling by NOTCH	0.000030115133937886405	0.000030115133937886405	+1	TP53,EGFR,NOTCH1,RUNX1,AKT1,ELF3,EP300,CCND1,HIST1H2BD,TBL1XR1,NCOR1
PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS%WIKIPATHWAYS_20190610%WP2572%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2572_r97626	0.000031171062090482634	0.000031171062090482634	+1	NOTCH1,CTNNB1,AKT1,CDKN1B,WT1,TLR4,CDKN1A
POSITIVE REGULATION OF CELL CYCLE ARREST%GOBP%GO:0071158	positive regulation of cell cycle arrest	0.000031171062090482634	0.000031171062090482634	+1	TP53,ATM,CDKN1B,BRCA1,CHEK2,EP300,CDKN1A
NOTCH%NETPATH%NOTCH	Notch	0.000031171062090482634	0.000031171062090482634	+1	PIK3R1,NOTCH1,FBXW7,AKT1,EP300,SIN3A,NCOR1
POSITIVE REGULATION OF DNA METABOLIC PROCESS%GOBP%GO:0051054	positive regulation of DNA metabolic process	0.000031737580010845645	0.000031737580010845645	+1	EGFR,AKT1,ATM,WT1,HGF,ATRX,BRCA1,USP9X,ATR,ERCC2
PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY	PID_PI3KCI_PATHWAY	0.000031737580010845645	0.000031737580010845645	+1	PIK3CA,PTEN,KRAS,PIK3R1,NRAS,PIK3CG
POSITIVE REGULATION OF UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	0.0000335314375412692	0.0000335314375412692	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 69%1221632	Meiotic synapsis	0.0000335314375412692	0.0000335314375412692	+1	STAG2,BRCA1,ATR,HIST1H2BD,SMC1A,SMC3,RAD21
SIGNALING BY FGFR%REACTOME%R-HSA-190236.2	Signaling by FGFR	0.0000335314375412692	0.0000335314375412692	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 69%5684996	ERK1 ERK2 pathway	0.00003433453427114025	0.00003433453427114025	+1	KRAS,EGFR,NF1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A,PTPN11
POSITIVE REGULATION OF CHROMOSOME ORGANIZATION%GOBP%GO:2001252	positive regulation of chromosome organization	0.00003433453427114025	0.00003433453427114025	+1	RB1,CTNNB1,ATM,ATRX,BRCA1,SMAD4,ATR,SIN3A,RAD21
TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 69%8878171	Transcriptional regulation by RUNX1	0.00003433453427114025	0.00003433453427114025	+1	ARID1A,PBRM1,GATA3,RUNX1,EP300,CCND1,CBFB,SIN3A,HIST1H2BD,PTPN11,LIFR
SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.2	Signaling by Activin	0.000035012513295131554	0.000035012513295131554	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
SIGNALING BY PDGF%REACTOME%R-HSA-186797.3	Signaling by PDGF	0.000035012513295131554	0.000035012513295131554	+1	PIK3CA,KRAS,PIK3R1,NRAS,PDGFRA,PTPN11
NOTCH%IOB%NOTCH	Notch	0.000035813885314645525	0.000035813885314645525	+1	PIK3R1,NOTCH1,FBXW7,EP300,SMAD4,SIN3A,NCOR1
REGULATION OF DEVELOPMENTAL GROWTH%GOBP%GO:0048638	regulation of developmental growth	0.000035813885314645525	0.000035813885314645525	+1	PTEN,NOTCH1,CDKN1B,WT1,ERBB4,FGFR2,FGFR3,CDKN1A,SIN3A
REGULATION OF PEPTIDYL-TYROSINE PHOSPHORYLATION%GOBP%GO:0050730	regulation of peptidyl-tyrosine phosphorylation	0.0000370394399604947	0.0000370394399604947	+1	TP53,EGFR,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PPP2R1A,PTPN11
HEART VALVE DEVELOPMENT%GOBP%GO:0003170	heart valve development	0.000038754438860232736	0.000038754438860232736	+1	GATA3,RB1,NOTCH1,SOX9,SMAD4,TGFBR2
SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)	Signaling events mediated by Stem cell factor receptor (c-Kit)	0.000038754438860232736	0.000038754438860232736	+1	PIK3CA,PTEN,PIK3R1,AKT1,KIT,PTPN11
PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY	PID_BARD1_PATHWAY	0.000038862150638575454	0.000038862150638575454	+1	TP53,NPM1,ATM,BRCA1,ATR
EMBRYONIC PATTERN SPECIFICATION%GOBP%GO:0009880	embryonic pattern specification	0.000038862150638575454	0.000038862150638575454	+1	TBX3,WT1,ERBB4,FGFR2,SMAD2
MAPK CASCADE%WIKIPATHWAYS_20190610%WP422%HOMO SAPIENS	http://www.wikipathways.org/instance/WP422_r95146	0.000038862150638575454	0.000038862150638575454	+1	KRAS,MAP3K1,NRAS,MAP2K4,BRAF
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.3	DNA Damage Telomere Stress Induced Senescence	0.000041486796716917987	0.000041486796716917987	+1	TP53,RB1,ATM,CDKN1B,HIST1H1C,CDKN1A,HIST1H2BD
INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036	Interleukin signaling pathway	0.000041486796716917987	0.000041486796716917987	+1	PIK3CA,NRAS,AKT1,BRAF,CDKN1B,MTOR,CDKN1A
DNA-TEMPLATED TRANSCRIPTION, INITIATION%GOBP%GO:0006352	DNA-templated transcription, initiation	0.00004155013343664493	0.00004155013343664493	+1	TP53,PTEN,NOTCH1,AR,SOX9,CCND1,CDKN1A,TAF1,CBFB,ERCC2
WNT SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP363%HOMO SAPIENS	http://www.wikipathways.org/instance/WP363_r97637	0.000042492828326396087	0.000042492828326396087	+1	APC,CTNNB1,AKT1,MTOR,CCND1,AXIN2
PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY	PID_KIT_PATHWAY	0.000042492828326396087	0.000042492828326396087	+1	PIK3CA,PTEN,PIK3R1,AKT1,KIT,PTPN11
UROGENITAL SYSTEM DEVELOPMENT%GOBP%GO:0001655	urogenital system development	0.000042990411720007845	0.000042990411720007845	+1	NF1,GATA3,AR,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
DNA IR-DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20190610%WP4016%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4016_r101923	0.0000444513084205342	0.0000444513084205342	+1	TP53,ATM,BRCA1,CHEK2,BRCA2,ATR,SMC1A
REGULATION OF MICROTUBULE CYTOSKELETON ORGANIZATION%GOBP%GO:0070507	regulation of microtubule cytoskeleton organization	0.00004509478575828854	0.00004509478575828854	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,SMC1A,SMC3
CELL DIVISION%REACTOME%R-HSA-68884.2	cell division	0.00004627932274975529	0.00004627932274975529	+1	STAG2,SMC1A,SMC3,RAD21
POSITIVE REGULATION OF CELL-CELL ADHESION%GOBP%GO:0022409	positive regulation of cell-cell adhesion	0.000046658295555516136	0.000046658295555516136	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,FOXA1,FOXA2,TGFBR2,CBFB,PTPN11
HALLMARK_G2M_CHECKPOINT%MSIGDB_C2%HALLMARK_G2M_CHECKPOINT	HALLMARK_G2M_CHECKPOINT	0.00004866500056218085	0.00004866500056218085	+1	CTCF,CDKN1B,ATRX,POLQ,CCND1,BRCA2,SMC1A,RAD21,CDKN2C,EZH2
NUCLEOSOME ORGANIZATION%GOBP%GO:0034728	nucleosome organization	0.00004956350842242642	0.00004956350842242642	+1	ARID1A,PBRM1,CTCF,NPM1,SOX9,ATRX,HIST1H1C,SETD2,HIST1H2BD
WNT%IOB%WNT	Wnt	0.00004992442544564746	0.00004992442544564746	+1	APC,CTNNB1,MAP3K1,CDH1,MAP2K4,AKT1,CCND1,AXIN2
POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE/THREONINE KINASE SIGNALING PATHWAY%GOBP%GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.00005133338264381285	0.00005133338264381285	+1	NOTCH1,STK11,EP300,SMAD4,ACVR1B,ACVR2A,SMAD2
COPPER HOMEOSTASIS%WIKIPATHWAYS_20190610%WP3286%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3286_r93705	0.00005153556456630879	0.00005153556456630879	+1	TP53,PIK3CA,PTEN,APC,AKT1,CCND1
REGULATION OF CELLULAR RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1900407	regulation of cellular response to oxidative stress	0.00005153556456630879	0.00005153556456630879	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
REGULATION OF INTRACELLULAR ESTROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033146	regulation of intracellular estrogen receptor signaling pathway	0.0000517770040747581	0.0000517770040747581	+1	RUNX1,CRIPAK,BRCA1,FOXA1,CBFB
FACTORS AND PATHWAYS AFFECTING INSULIN-LIKE GROWTH FACTOR (IGF1)-AKT SIGNALING%WIKIPATHWAYS_20190610%WP3850%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3850_r88165	0.0000517770040747581	0.0000517770040747581	+1	PTEN,AKT1,PIK3CG,MTOR,SMAD2
BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY	BIOCARTA_EGF_PATHWAY	0.0000517770040747581	0.0000517770040747581	+1	PIK3CA,EGFR,PIK3R1,MAP3K1,MAP2K4
ANDROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0030521	androgen receptor signaling pathway	0.0000517770040747581	0.0000517770040747581	+1	ARID1A,RB1,CTNNB1,AR,BRCA1
WNT%NETPATH%WNT	Wnt	0.00005199744717249646	0.00005199744717249646	+1	APC,CTNNB1,MAP3K1,CDH1,MAP2K4,AKT1,CCND1,AXIN2
SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.3	Signaling by ERBB4	0.000056500658930594954	0.000056500658930594954	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS,NCOR1
IL6%NETPATH%IL6	IL6	0.00005871159884607065	0.00005871159884607065	+1	PIK3R1,RB1,MAP2K4,AKT1,AR,EP300,PTPN11
H19 ACTION RB-E2F1 SIGNALING AND CDK-BETA-CATENIN ACTIVITY%WIKIPATHWAYS_20190610%WP3969%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3969_r97690	0.00005973313350404138	0.00005973313350404138	+1	RB1,CTNNB1,CDH1,CCND1
BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY	BIOCARTA_LONGEVITY_PATHWAY	0.00005973313350404138	0.00005973313350404138	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 69%9034015	Signaling by NTRK3 (TRKC)	0.00005973313350404138	0.00005973313350404138	+1	PIK3CA,KRAS,PIK3R1,NRAS
RESPONSE TO INDOLE-3-METHANOL%GOBP%GO:0071680	response to indole-3-methanol	0.00006016877613981724	0.00006016877613981724	+1	CTNNB1,CDH1,BRCA1
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.1	RUNX1 regulates transcription of genes involved in interleukin signaling	0.00006016877613981724	0.00006016877613981724	+1	RUNX1,CBFB,LIFR
CELLULAR RESPONSE TO INDOLE-3-METHANOL%GOBP%GO:0071681	cellular response to indole-3-methanol	0.00006016877613981724	0.00006016877613981724	+1	CTNNB1,CDH1,BRCA1
MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 69%8851907	MET activates PI3K AKT signaling	0.00006016877613981724	0.00006016877613981724	+1	PIK3CA,PIK3R1,HGF
INSULIN SIGNALING%WIKIPATHWAYS_20190610%WP481%HOMO SAPIENS	http://www.wikipathways.org/instance/WP481_r94171	0.00006065339141157404	0.00006065339141157404	+1	PIK3CA,PTEN,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG,MTOR,PTPN11
CELL FATE COMMITMENT%GOBP%GO:0045165	cell fate commitment	0.00006065339141157404	0.00006065339141157404	+1	APC,GATA3,SOX9,WT1,FGFR2,FOXA2,SOX17,SMAD2
S PHASE%REACTOME DATABASE ID RELEASE 69%69242	S Phase	0.00006065339141157404	0.00006065339141157404	+1	RB1,AKT1,STAG2,CDKN1B,CCND1,CDKN1A,SMC1A,SMC3,RAD21
DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR RESULTING IN CELL CYCLE ARREST%GOBP%GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	0.00006080782647440011	0.00006080782647440011	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
BLOOD VESSEL MORPHOGENESIS%GOBP%GO:0048514	blood vessel morphogenesis	0.00006186855415272769	0.00006186855415272769	+1	NF1,NOTCH1,CTNNB1,AKT1,WT1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
SIGNAL TRANSDUCTION INVOLVED IN MITOTIC G1 DNA DAMAGE CHECKPOINT%GOBP%GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint	0.00006590276136364972	0.00006590276136364972	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
EGF/EGFR SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP437%HOMO SAPIENS	http://www.wikipathways.org/instance/WP437_r79266	0.00006590276136364972	0.00006590276136364972	+1	PTEN,KRAS,EGFR,PIK3R1,MAP3K1,AKT1,BRAF,MTOR,PTPN11
INTRACELLULAR SIGNAL TRANSDUCTION INVOLVED IN G1 DNA DAMAGE CHECKPOINT%GOBP%GO:1902400	intracellular signal transduction involved in G1 DNA damage checkpoint	0.00006590276136364972	0.00006590276136364972	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
SIGNAL TRANSDUCTION INVOLVED IN MITOTIC CELL CYCLE CHECKPOINT%GOBP%GO:0072413	signal transduction involved in mitotic cell cycle checkpoint	0.00006590276136364972	0.00006590276136364972	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY	BIOCARTA_PPARA_PATHWAY	0.00006590276136364972	0.00006590276136364972	+1	PIK3CA,PIK3R1,RB1,PIK3CG,EP300,NCOR1
SIGNAL TRANSDUCTION INVOLVED IN MITOTIC DNA DAMAGE CHECKPOINT%GOBP%GO:1902402	signal transduction involved in mitotic DNA damage checkpoint	0.00006590276136364972	0.00006590276136364972	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
PROTEIN LOCALIZATION TO CHROMOSOME%GOBP%GO:0034502	protein localization to chromosome	0.00006590276136364972	0.00006590276136364972	+1	RB1,CTCF,ATRX,BRCA2,ATR,RAD21
SIGNAL TRANSDUCTION INVOLVED IN MITOTIC DNA INTEGRITY CHECKPOINT%GOBP%GO:1902403	signal transduction involved in mitotic DNA integrity checkpoint	0.00006590276136364972	0.00006590276136364972	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CDKN1A
REGULATION OF UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:2000058	regulation of ubiquitin-dependent protein catabolic process	0.00006651789192576182	0.00006651789192576182	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE	Signaling events mediated by focal adhesion kinase	0.00007245967565508938	0.00007245967565508938	+1	PIK3CA,PIK3R1,ARHGAP35,MAP2K4,BRAF,CCND1
SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.4	Signaling by FGFR in disease	0.00007245967565508938	0.00007245967565508938	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR2,FGFR3
DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.3	DNA Double-Strand Break Repair	0.00007381869284618155	0.00007381869284618155	+1	TP53,BAP1,ATM,BRCA1,POLQ,CHEK2,BRCA2,ATR,HIST1H2BD
MITOTIC DNA DAMAGE CHECKPOINT%GOBP%GO:0044773	mitotic DNA damage checkpoint	0.00007381869284618155	0.00007381869284618155	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 69%180292	GAB1 signalosome	0.00007381869284618155	0.00007381869284618155	+1	PIK3CA,EGFR,PIK3R1,PTPN11
HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030	Hypoxia response via HIF activation	0.00007381869284618155	0.00007381869284618155	+1	PTEN,VHL,AKT1,MTOR
MAMMARY GLAND DEVELOPMENT PATHWAY - EMBRYONIC DEVELOPMENT (STAGE 1 OF 4)%WIKIPATHWAYS_20190610%WP2813%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2813_r102405	0.00007381869284618155	0.00007381869284618155	+1	CDH1,AKT1,ERBB4,CCND1
BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY	BIOCARTA_ACH_PATHWAY	0.00007381869284618155	0.00007381869284618155	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY	PID_IL2_PI3K_PATHWAY	0.00007565921145805505	0.00007565921145805505	+1	PIK3CA,PIK3R1,AKT1,MTOR,PTPN11
PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY	PID_ATM_PATHWAY	0.00007565921145805505	0.00007565921145805505	+1	ATM,BRCA1,CHEK2,SMC1A,SMC3
ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY	ATM pathway	0.00007565921145805505	0.00007565921145805505	+1	ATM,BRCA1,CHEK2,SMC1A,SMC3
NEGATIVE REGULATION OF MAPK CASCADE%GOBP%GO:0043409	negative regulation of MAPK cascade	0.00007708663138043617	0.00007708663138043617	+1	PTEN,NF1,TLR4,SMAD4,PPP2R1A,MAPK8IP1,MECOM,NCOR1
PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY	PID_FAK_PATHWAY	0.00007787477074310517	0.00007787477074310517	+1	PIK3CA,PIK3R1,ARHGAP35,MAP2K4,BRAF,CCND1
KITRECEPTOR%IOB%KITRECEPTOR	KitReceptor	0.00008428567767661327	0.00008428567767661327	+1	PIK3CA,PIK3R1,AKT1,MTOR,KIT,EP300,PTPN11
COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY	Coregulation of Androgen receptor activity	0.0000851012795716786	0.0000851012795716786	+1	CDKN2A,CTNNB1,AKT1,AR,BRCA1,CCND1
NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING	Neurotrophic factor-mediated Trk receptor signaling	0.0000851012795716786	0.0000851012795716786	+1	PIK3CA,KRAS,PIK3R1,NRAS,CCND1,PTPN11
FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS	Fc-epsilon receptor I signaling in mast cells	0.0000851012795716786	0.0000851012795716786	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PTPN11
TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 69%8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.00008593610476876364	0.00008593610476876364	+1	EGFR,NPM1,KIT,EP300,CDKN1A
REGULATION OF ORGAN GROWTH%GOBP%GO:0046620	regulation of organ growth	0.00008593610476876364	0.00008593610476876364	+1	PTEN,NOTCH1,WT1,ERBB4,FGFR2
REGULATION OF EPITHELIAL CELL PROLIFERATION%GOBP%GO:0050678	regulation of epithelial cell proliferation	0.00008717334607023524	0.00008717334607023524	+1	EGFR,NF1,GATA3,FBXW7,NRAS,AKT1,SOX9,FGFR2,BRCA2,EGR3
TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052	TGF-beta signaling pathway	0.00008881250018681492	0.00008881250018681492	+1	NRAS,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.3	VEGFA-VEGFR2 Pathway	0.00008881250018681492	0.00008881250018681492	+1	PIK3CA,KRAS,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056	VEGF signaling pathway	0.00009077086553392772	0.00009077086553392772	+1	PIK3CA,PIK3R1,NRAS,AKT1,BRAF,PIK3CG
PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY	PID_FCER1_PATHWAY	0.00009077086553392772	0.00009077086553392772	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PTPN11
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 69%8934593	Regulation of RUNX1 Expression and Activity	0.00009077086553392772	0.00009077086553392772	+1	RUNX1,CCND1,CBFB,PTPN11
INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS	Integrins in angiogenesis	0.00009077086553392772	0.00009077086553392772	+1	PIK3CA,PIK3R1,AKT1,CDKN1B,TGFBR2,PTPN11
BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY	BIOCARTA_IL7_PATHWAY	0.00009077086553392772	0.00009077086553392772	+1	PIK3CA,PIK3R1,PIK3CG,EP300
FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-9617828.1	FOXO-mediated transcription of cell cycle genes	0.00009077086553392772	0.00009077086553392772	+1	CDKN1B,SMAD4,CDKN1A,SMAD2
PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY	PID_AR_PATHWAY	0.00009077086553392772	0.00009077086553392772	+1	CDKN2A,CTNNB1,AKT1,AR,BRCA1,CCND1
REGULATION OF RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1902882	regulation of response to oxidative stress	0.00009077086553392772	0.00009077086553392772	+1	FBXW7,NFE2L2,AKT1,HGF,TLR4,LRRK2
APOPTOTIC SIGNALING PATHWAY%GOBP%GO:0097190	apoptotic signaling pathway	0.00009197130831861919	0.00009197130831861919	+1	TP53,STK11,ATM,TLR4,BRCA1,CHEK2,EP300,FGFR3,CDKN1A,ACVR1B
PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 69%1912408	Pre-NOTCH Transcription and Translation	0.00009284839482849897	0.00009284839482849897	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.1	Regulation of TP53 Activity through Phosphorylation	0.00009284839482849897	0.00009284839482849897	+1	TP53,STK11,ATM,BRCA1,CHEK2,TAF1,ATR
IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K	IL2 signaling events mediated by PI3K	0.00009506582131762772	0.00009506582131762772	+1	PIK3CA,PIK3R1,AKT1,MTOR,PTPN11
GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS	GMCSF-mediated signaling events	0.00009506582131762772	0.00009506582131762772	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 69%8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	0.00009506582131762772	0.00009506582131762772	+1	ARID1A,PBRM1,RUNX1,EP300,CBFB
PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY	PID_TRKR_PATHWAY	0.00009816072774527334	0.00009816072774527334	+1	PIK3CA,KRAS,PIK3R1,NRAS,CCND1,PTPN11
REGULATION OF DNA BINDING%GOBP%GO:0051101	regulation of DNA binding	0.0000984680601756431	0.0000984680601756431	+1	GATA3,RB1,CTNNB1,EP300,TAF1,SIN3A,NSD1
UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 69%5689880	Ub-specific processing proteases	0.0001016917925482222	0.0001016917925482222	+1	TP53,PTEN,GATA3,KEAP1,AR,SMAD4,USP9X,HIST1H2BD,SMAD2,AXIN2
POSITIVE REGULATION OF ACTIVIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0032927	positive regulation of activin receptor signaling pathway	0.00010329685477167045	0.00010329685477167045	+1	ACVR1B,ACVR2A,SMAD2
SOMATROPH AXIS (GH) AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20190610%WP4186%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4186_r95479	0.00010329685477167045	0.00010329685477167045	+1	PTEN,AKT1,MTOR
RESPONSE TO UV-A%GOBP%GO:0070141	response to UV-A	0.00010329685477167045	0.00010329685477167045	+1	EGFR,AKT1,CCND1
LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.1	Loss of Function of SMAD2 3 in Cancer	0.00010329685477167045	0.00010329685477167045	+1	SMAD4,TGFBR2,SMAD2
CELLULAR RESPONSE TO LIGHT STIMULUS%GOBP%GO:0071482	cellular response to light stimulus	0.00010410524170029499	0.00010410524170029499	+1	TP53,NPM1,STK11,EP300,CDKN1A,TAF1,ATR
REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY%GOBP%GO:0043551	regulation of phosphatidylinositol 3-kinase activity	0.00010663758752574339	0.00010663758752574339	+1	PIK3R1,FLT3,KIT,PDGFRA,FGFR3
PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY	PID_GMCSF_PATHWAY	0.00010663758752574339	0.00010663758752574339	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY	BIOCARTA_ERK5_PATHWAY	0.00011067689807541576	0.00011067689807541576	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
TGF-B SIGNALING IN THYROID CELLS FOR EPITHELIAL-MESENCHYMAL TRANSITION%WIKIPATHWAYS_20190610%WP3859%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3859_r90120	0.00011067689807541576	0.00011067689807541576	+1	CDH1,AKT1,SMAD4,SMAD2
POSITIVE REGULATION OF PROTEOLYSIS INVOLVED IN CELLULAR PROTEIN CATABOLIC PROCESS%GOBP%GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process	0.00011067689807541576	0.00011067689807541576	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS%GOBP%GO:0045732	positive regulation of protein catabolic process	0.00011182950158549669	0.00011182950158549669	+1	PTEN,APC,FBXW7,KEAP1,NFE2L2,CEBPA,CDKN1B,LRRK2,TAF1
VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK	Validated nuclear estrogen receptor alpha network	0.00011404718193563855	0.00011404718193563855	+1	BRCA1,EP300,CCND1,SMAD4,NCOR1,AXIN2
PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY	PID_ERA_GENOMIC_PATHWAY	0.00011404718193563855	0.00011404718193563855	+1	BRCA1,EP300,CCND1,SMAD4,NCOR1,AXIN2
EMBRYONIC ORGAN DEVELOPMENT%GOBP%GO:0048568	embryonic organ development	0.00011565888725866218	0.00011565888725866218	+1	GATA3,NOTCH1,CTNNB1,SOX9,KIT,PDGFRA,FGFR2,TGFBR2,SOX17
CELLULAR RESPONSE TO RADIATION%GOBP%GO:0071478	cellular response to radiation	0.00011565888725866218	0.00011565888725866218	+1	TP53,NPM1,STK11,ATM,EP300,CDKN1A,TAF1,ATR
CHROMATIN ASSEMBLY%GOBP%GO:0031497	chromatin assembly	0.00011565888725866218	0.00011565888725866218	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD
SIGNALING BY NTRKS%REACTOME%R-HSA-166520.4	Signaling by NTRKs	0.0001161507574910979	0.0001161507574910979	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A,PTPN11
BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY	BIOCARTA_FCER1_PATHWAY	0.00011836990877309582	0.00011836990877309582	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,PIK3CG
INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1	Internalization of ErbB1	0.00011836990877309582	0.00011836990877309582	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
VENTRICULAR SEPTUM DEVELOPMENT%GOBP%GO:0003281	ventricular septum development	0.00011836990877309582	0.00011836990877309582	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 69%6796648	TP53 Regulates Transcription of DNA Repair Genes	0.0001222686315749429	0.0001222686315749429	+1	TP53,ATM,BRCA1,ATR,CDK12,ERCC2
SIGNALING BY MET%REACTOME DATABASE ID RELEASE 69%6806834	Signaling by MET	0.0001222686315749429	0.0001222686315749429	+1	PIK3CA,KRAS,PIK3R1,NRAS,HGF,PTPN11
LEPTIN%NETPATH%LEPTIN	Leptin	0.00012229524587883787	0.00012229524587883787	+1	PTEN,EGFR,PIK3R1,AKT1,MTOR,EP300,PTPN11
MITOTIC DNA INTEGRITY CHECKPOINT%GOBP%GO:0044774	mitotic DNA integrity checkpoint	0.00012229524587883787	0.00012229524587883787	+1	TP53,ATM,CDKN1B,CHEK2,EP300,CCND1,CDKN1A
REGULATION OF MICROTUBULE-BASED PROCESS%GOBP%GO:0032886	regulation of microtubule-based process	0.00012957924742679582	0.00012957924742679582	+1	APC,NAV3,CTNNB1,NPM1,EPHA3,STAG2,BRCA1,SMC1A,SMC3
STEM CELL DIFFERENTIATION%GOBP%GO:0048863	stem cell differentiation	0.00013016368800616453	0.00013016368800616453	+1	TP53,NOTCH1,SOX9,ERBB4,KIT,SETD2,FGFR2
MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20190610%WP1545%HOMO SAPIENS	http://www.wikipathways.org/instance/WP1545_r102985	0.00013129711871131847	0.00013129711871131847	+1	TP53,ATM,CDKN1B,CCND1,CDKN1A
SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP	Signaling events mediated by TCPTP	0.00013129711871131847	0.00013129711871131847	+1	PIK3CA,EGFR,PIK3R1,HGF,ATR
P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 69%69563	p53-Dependent G1 DNA Damage Response	0.00013129711871131847	0.00013129711871131847	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 69%388841	Costimulation by the CD28 family	0.00013129711871131847	0.00013129711871131847	+1	PIK3CA,PIK3R1,AKT1,MTOR,PPP2R1A,PTPN11
P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 69%69580	p53-Dependent G1 S DNA damage checkpoint	0.00013129711871131847	0.00013129711871131847	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 69%5655253	Signaling by FGFR2 in disease	0.00013129711871131847	0.00013129711871131847	+1	PIK3CA,KRAS,PIK3R1,NRAS,FGFR2
BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY	BIOCARTA_GCR_PATHWAY	0.00013186645259162538	0.00013186645259162538	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 69%6804760	Regulation of TP53 Activity through Methylation	0.00013186645259162538	0.00013186645259162538	+1	TP53,ATM,CHEK2,EP300
RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 69%5673001	RAF MAP kinase cascade	0.00013798146623785585	0.00013798146623785585	+1	KRAS,EGFR,NF1,FLT3,NRAS,BRAF,HGF,KIT,PDGFRA,PPP2R1A
BLOOD VESSEL DEVELOPMENT%GOBP%GO:0001568	blood vessel development	0.00014294213277784204	0.00014294213277784204	+1	NF1,NOTCH1,CTNNB1,AKT1,WT1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
EPITHELIAL TUBE MORPHOGENESIS%GOBP%GO:0060562	epithelial tube morphogenesis	0.0001436027911142474	0.0001436027911142474	+1	GATA3,NOTCH1,CTNNB1,SOX9,WT1,FGFR2,TGFBR2,SOX17
SIGNALING BY TGF-BETA FAMILY MEMBERS%REACTOME%R-HSA-9006936.4	Signaling by TGF-beta family members	0.00014419790783332952	0.00014419790783332952	+1	SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,NCOR1,SMAD2
SIGNALING BY VEGF%REACTOME%R-HSA-194138.1	Signaling by VEGF	0.00014419790783332952	0.00014419790783332952	+1	PIK3CA,KRAS,PIK3R1,CTNNB1,NRAS,AKT1,MTOR
IL-5 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP127%HOMO SAPIENS	http://www.wikipathways.org/instance/WP127_r78498	0.00014616788594417897	0.00014616788594417897	+1	KRAS,PIK3R1,AKT1,PIK3CG,PTPN11
PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING	Plasma membrane estrogen receptor signaling	0.00014616788594417897	0.00014616788594417897	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1
SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2	Signaling events mediated by VEGFR1 and VEGFR2	0.00015164992743671137	0.00015164992743671137	+1	PIK3CA,PIK3R1,CTNNB1,AKT1,BRAF,PTPN11
G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.2	G1 S DNA Damage Checkpoints	0.00015164992743671137	0.00015164992743671137	+1	TP53,CDKN2A,ATM,CDKN1B,CHEK2,CDKN1A
PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY	PID_CXCR4_PATHWAY	0.00015181859001461108	0.00015181859001461108	+1	PIK3CA,PTEN,PIK3R1,AKT1,PIK3CG,MTOR,PTPN11
NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20190610%WP2064%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2064_r101922	0.00015181859001461108	0.00015181859001461108	+1	NOTCH1,CTNNB1,CDH1,SOX9,FGFR2,FGFR3,AXIN2
REGULATION OF MYELOID CELL DIFFERENTIATION%GOBP%GO:0045637	regulation of myeloid cell differentiation	0.00015381833279721335	0.00015381833279721335	+1	FBXW7,RUNX1,MTOR,TLR4,EP300,CBFB,SIN3A,ACVR1B,ACVR2A
POSITIVE REGULATION OF PEPTIDYL-TYROSINE PHOSPHORYLATION%GOBP%GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	0.00015564262060128623	0.00015564262060128623	+1	TP53,FBXW7,FLT3,HGF,ERBB4,KIT,FGFR3,PTPN11
REGULATION OF GENE EXPRESSION, EPIGENETIC%GOBP%GO:0040029	regulation of gene expression, epigenetic	0.00015564262060128623	0.00015564262060128623	+1	ARID1A,DNMT3A,CTCF,AJUBA,BRCA1,HIST1H1C,EP300,SF3B1,SMAD2,EZH2
POSITIVE REGULATION OF HEART GROWTH%GOBP%GO:0060421	positive regulation of heart growth	0.00015783981820740545	0.00015783981820740545	+1	NOTCH1,WT1,ERBB4,FGFR2
POSITIVE REGULATION OF ORGAN GROWTH%GOBP%GO:0046622	positive regulation of organ growth	0.00015783981820740545	0.00015783981820740545	+1	NOTCH1,WT1,ERBB4,FGFR2
SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 69%1181150	Signaling by NODAL	0.00015783981820740545	0.00015783981820740545	+1	SMAD4,ACVR1B,ACVR2A,SMAD2
ENDOCARDIAL CELL DIFFERENTIATION%GOBP%GO:0060956	endocardial cell differentiation	0.0001587767914926417	0.0001587767914926417	+1	NOTCH1,SMAD4,SOX17
RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-HSA-8941855.1	RUNX3 regulates CDKN1A transcription	0.0001587767914926417	0.0001587767914926417	+1	TP53,SMAD4,CDKN1A
REGULATION OF HISTONE METHYLATION%GOBP%GO:0031060	regulation of histone methylation	0.0001587767914926417	0.0001587767914926417	+1	CTNNB1,ATRX,BRCA1,SMAD4,NSD1
PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY	PID_VEGFR1_2_PATHWAY	0.0001587767914926417	0.0001587767914926417	+1	PIK3CA,PIK3R1,CTNNB1,AKT1,BRAF,PTPN11
SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.1	Signaling by TGF-beta Receptor Complex in Cancer	0.0001587767914926417	0.0001587767914926417	+1	SMAD4,TGFBR2,SMAD2
STEM CELL POPULATION MAINTENANCE%GOBP%GO:0019827	stem cell population maintenance	0.0001587767914926417	0.0001587767914926417	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
CARDIAC ENDOTHELIAL CELL DIFFERENTIATION%GOBP%GO:0003348	cardiac endothelial cell differentiation	0.0001587767914926417	0.0001587767914926417	+1	NOTCH1,SMAD4,SOX17
PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY	PID_ER_NONGENOMIC_PATHWAY	0.0001587767914926417	0.0001587767914926417	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1
PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY	PID_ERBB1_INTERNALIZATION_PATHWAY	0.0001587767914926417	0.0001587767914926417	+1	PIK3CA,KRAS,EGFR,PIK3R1,NRAS
POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION%GOBP%GO:1901989	positive regulation of cell cycle phase transition	0.0001587767914926417	0.0001587767914926417	+1	EGFR,RB1,NPM1,AKT1,CCND1,EZH2
RENAL SYSTEM DEVELOPMENT%GOBP%GO:0072001	renal system development	0.00015878890638668536	0.00015878890638668536	+1	NF1,GATA3,SOX9,WT1,LRRK2,PDGFRA,FGFR2,SOX17
KITRECEPTOR%NETPATH%KITRECEPTOR	KitReceptor	0.00016589928165846414	0.00016589928165846414	+1	PIK3CA,PIK3R1,AKT1,MTOR,KIT,EP300,PTPN11
MAINTENANCE OF CELL NUMBER%GOBP%GO:0098727	maintenance of cell number	0.00017112188213077328	0.00017112188213077328	+1	NOTCH1,CTNNB1,SOX9,KIT,SMAD4,SMAD2
SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 69%74752	Signaling by Insulin receptor	0.00017112188213077328	0.00017112188213077328	+1	PIK3CA,KRAS,PIK3R1,FLT3,NRAS,PTPN11
HALLMARK_UV_RESPONSE_DN%MSIGDB_C2%HALLMARK_UV_RESPONSE_DN	HALLMARK_UV_RESPONSE_DN	0.00017419667232965364	0.00017419667232965364	+1	PTEN,RUNX1,CDKN1B,ATRX,KIT,TGFBR2,ACVR2A,SPOP
HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDB_C2%HALLMARK_PI3K_AKT_MTOR_SIGNALING	HALLMARK_PI3K_AKT_MTOR_SIGNALING	0.00017514203998156614	0.00017514203998156614	+1	PTEN,EGFR,AKT1,CDKN1B,CDKN1A,PTPN11,SMAD2
DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-HSA-3769402.3	Deactivation of the beta-catenin transactivating complex	0.00017578916694491252	0.00017578916694491252	+1	APC,CTNNB1,AKT1,SOX9,SOX17
METANEPHROS DEVELOPMENT%GOBP%GO:0001656	metanephros development	0.00017578916694491252	0.00017578916694491252	+1	NF1,GATA3,SOX9,WT1,PDGFRA
GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959	Gastrin_CCK2R_240212	0.00018121712036295963	0.00018121712036295963	+1	PTEN,PIK3R1,CTNNB1,CDH1,MAP2K4,AKT1,BRAF,PTPN11
EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.2	Epigenetic regulation of gene expression	0.00018121712036295963	0.00018121712036295963	+1	DNMT3A,TET2,EP300,SF3B1,SIN3A,HIST1H2BD,ERCC2,EZH2
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 69%3108214	SUMOylation of DNA damage response and repair proteins	0.0001830572600257262	0.0001830572600257262	+1	CDKN2A,STAG2,BRCA1,SMC1A,SMC3,RAD21
BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY	BIOCARTA_IGF1_PATHWAY	0.00018389896973842437	0.00018389896973842437	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN CELLULAR RESPONSE TO CHEMICAL STIMULUS%GOBP%GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	0.00018389896973842437	0.00018389896973842437	+1	NOTCH1,NFE2L2,EP300,SMAD4
TP53 NETWORK%WIKIPATHWAYS_20190610%WP1742%HOMO SAPIENS	http://www.wikipathways.org/instance/WP1742_r95548	0.00018389896973842437	0.00018389896973842437	+1	TP53,CDKN2A,ATM,CDKN1A
G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:0000082	G1/S transition of mitotic cell cycle	0.00018389896973842437	0.00018389896973842437	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,ACVR1B,CDKN2C
PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY	PID_TCPTP_PATHWAY	0.00019366923831811938	0.00019366923831811938	+1	PIK3CA,EGFR,PIK3R1,HGF,ATR
PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048	PI3 kinase pathway	0.00019366923831811938	0.00019366923831811938	+1	PIK3CA,PTEN,PIK3R1,NRAS,AKT1
CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:0044843	cell cycle G1/S phase transition	0.00019366923831811938	0.00019366923831811938	+1	CDKN2A,RB1,CDKN1B,CCND1,CDKN1A,ACVR1B,CDKN2C
MITOTIC G1-G1 S PHASES%REACTOME%R-HSA-453279.3	Mitotic G1-G1 S phases	0.00019634737474988814	0.00019634737474988814	+1	CDKN2A,RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A,CDKN2C
RESPONSE TO HYPOXIA%GOBP%GO:0001666	response to hypoxia	0.0001998565197743053	0.0001998565197743053	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
IL4%NETPATH%IL4	IL4	0.0002105044917974569	0.0002105044917974569	+1	PIK3CA,PIK3R1,CEBPA,AKT1,EP300,PTPN11
A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING	a6b1 and a6b4 Integrin signaling	0.00021452928069943313	0.00021452928069943313	+1	PIK3CA,EGFR,PIK3R1,CDH1,AKT1
FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS	FOXA2 and FOXA3 transcription factor networks	0.00021452928069943313	0.00021452928069943313	+1	NF1,CEBPA,AKT1,FOXA1,FOXA2
BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY	BIOCARTA_TCR_PATHWAY	0.00021452928069943313	0.00021452928069943313	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,PIK3CG
PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 69%1912422	Pre-NOTCH Expression and Processing	0.0002149729083668859	0.0002149729083668859	+1	TP53,NOTCH1,RUNX1,ELF3,EP300,CCND1,HIST1H2BD
POSITIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING%GOBP%GO:2000679	positive regulation of transcription regulatory region DNA binding	0.00021676619836988656	0.00021676619836988656	+1	GATA3,RB1,CTNNB1,EP300
BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY	BIOCARTA_AKT_PATHWAY	0.00021676619836988656	0.00021676619836988656	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY	BIOCARTA_INSULIN_PATHWAY	0.00021676619836988656	0.00021676619836988656	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
REGULATION OF TRANSCRIPTION BY RNA POLYMERASE III%GOBP%GO:0006359	regulation of transcription by RNA polymerase III	0.00021676619836988656	0.00021676619836988656	+1	CEBPA,AR,MTOR,BRCA1
CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-HSA-389357.1	CD28 dependent PI3K Akt signaling	0.00021676619836988656	0.00021676619836988656	+1	PIK3CA,PIK3R1,AKT1,MTOR
RESPONSE TO DECREASED OXYGEN LEVELS%GOBP%GO:0036293	response to decreased oxygen levels	0.00022077199874390887	0.00022077199874390887	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
REGULATION OF JAK-STAT CASCADE%GOBP%GO:0046425	regulation of JAK-STAT cascade	0.00022451717111759422	0.00022451717111759422	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
REGULATION OF WOUND HEALING%GOBP%GO:0061041	regulation of wound healing	0.00022451717111759422	0.00022451717111759422	+1	PTEN,CDKN1B,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A
ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR	AndrogenReceptor	0.00023283782869897729	0.00023283782869897729	+1	PIK3R1,AKT1,AR
PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY	PID_HNF3B_PATHWAY	0.00023283782869897729	0.00023283782869897729	+1	NF1,CEBPA,AKT1,FOXA1,FOXA2
EGFR TRANSACTIVATION BY GASTRIN%REACTOME DATABASE ID RELEASE 69%2179392	EGFR Transactivation by Gastrin	0.00023283782869897729	0.00023283782869897729	+1	KRAS,EGFR,NRAS
REGULATION OF RNA POLYMERASE II REGULATORY REGION SEQUENCE-SPECIFIC DNA BINDING%GOBP%GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	0.00023283782869897729	0.00023283782869897729	+1	EP300,TAF1,NSD1
SIG_CHEMOTAXIS%MSIGDB_C2%SIG_CHEMOTAXIS	SIG_CHEMOTAXIS	0.00023283782869897729	0.00023283782869897729	+1	PIK3CA,PTEN,PIK3R1,AKT1,PIK3CG
CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20190610%WP4191%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4191_r96444	0.00023283782869897729	0.00023283782869897729	+1	TP53,AKT1,MTOR
INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 69%6785807	Interleukin-4 and Interleukin-13 signaling	0.00023485617858625473	0.00023485617858625473	+1	TP53,PIK3R1,GATA3,AKT1,HGF,CCND1,CDKN1A
REGULATION OF NOTCH SIGNALING PATHWAY%GOBP%GO:0008593	regulation of Notch signaling pathway	0.00023540367374670979	0.00023540367374670979	+1	EGFR,NOTCH1,FBXW7,AKT1,ELF3,EP300
CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION%GOBP%GO:0021953	central nervous system neuron differentiation	0.00023540367374670979	0.00023540367374670979	+1	PTEN,CTNNB1,ARHGAP35,ERBB4,FGFR2,SIN3A
PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY	PID_AVB3_INTEGRIN_PATHWAY	0.00023540367374670979	0.00023540367374670979	+1	PIK3CA,PIK3R1,AKT1,CDKN1B,TGFBR2,PTPN11
HALLMARK_P53_PATHWAY%MSIGDB_C2%HALLMARK_P53_PATHWAY	HALLMARK_P53_PATHWAY	0.0002425220702568389	0.0002425220702568389	+1	TP53,CDKN2A,RB1,NOTCH1,FBXW7,CEBPA,HIST1H1C,CDKN1A,ACVR1B
RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 69%5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.0002494422538614098	0.0002494422538614098	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.1	Downregulation of SMAD2 3:SMAD4 transcriptional activity	0.0002494422538614098	0.0002494422538614098	+1	SMAD4,USP9X,NCOR1,SMAD2
BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY	BIOCARTA_RAS_PATHWAY	0.0002494422538614098	0.0002494422538614098	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
LEPTIN SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP2034%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2034_r89856	0.0002494422538614098	0.0002494422538614098	+1	PTEN,PIK3R1,AKT1,MTOR,CCND1,PTPN11
CELLULAR RESPONSE TO DRUG%GOBP%GO:0035690	cellular response to drug	0.0002494422538614098	0.0002494422538614098	+1	TP53,CTNNB1,CDH1,NFE2L2,SOX9,ATRX,BRCA1,LRRK2,TAF1
FLK2 FLT3%IOB%FLK2 FLT3	FLK2 FLT3	0.0002494422538614098	0.0002494422538614098	+1	FLT3,CEBPA,AKT1,PTPN11
SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.2	Signaling by NTRK1 (TRKA)	0.0002494422538614098	0.0002494422538614098	+1	PIK3CA,KRAS,PIK3R1,NRAS,BRAF,PPP2R1A
PROLACTIN SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP2037%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2037_r95112	0.0002494422538614098	0.0002494422538614098	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,MTOR,PTPN11
NEGATIVE REGULATION OF MACROAUTOPHAGY%GOBP%GO:0016242	negative regulation of macroautophagy	0.0002494422538614098	0.0002494422538614098	+1	PIK3CA,AKT1,MTOR,LRRK2
HEART DEVELOPMENT%WIKIPATHWAYS_20190610%WP1591%HOMO SAPIENS	http://www.wikipathways.org/instance/WP1591_r103004	0.000251763075262376	0.000251763075262376	+1	NOTCH1,CTNNB1,SMAD4,FOXA2,PTPN11
PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY	PID_A6B1_A6B4_INTEGRIN_PATHWAY	0.000251763075262376	0.000251763075262376	+1	PIK3CA,EGFR,PIK3R1,CDH1,AKT1
MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:0002009	morphogenesis of an epithelium	0.00025636485334550973	0.00025636485334550973	+1	GATA3,NOTCH1,CTNNB1,ARHGAP35,SOX9,WT1,FGFR2,TGFBR2,SOX17
DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.1	DNA Double Strand Break Response	0.00026647741488239167	0.00026647741488239167	+1	TP53,BAP1,ATM,BRCA1,CHEK2,HIST1H2BD
CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS%GOBP%GO:0071560	cellular response to transforming growth factor beta stimulus	0.0002681566361405911	0.0002681566361405911	+1	SOX9,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:0097193	intrinsic apoptotic signaling pathway	0.0002681566361405911	0.0002681566361405911	+1	TP53,STK11,ATM,BRCA1,CHEK2,EP300,CDKN1A
REGULATION OF STAT CASCADE%GOBP%GO:1904892	regulation of STAT cascade	0.0002681566361405911	0.0002681566361405911	+1	VHL,NOTCH1,FLT3,ERBB4,KIT,FGFR3,PPP2R1A
POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS%GOBP%GO:1903364	positive regulation of cellular protein catabolic process	0.0002681566361405911	0.0002681566361405911	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY	PID_IL6_7_PATHWAY	0.00027480400703474965	0.00027480400703474965	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PTPN11
REGULATION OF FIBROBLAST PROLIFERATION%GOBP%GO:0048145	regulation of fibroblast proliferation	0.00027480400703474965	0.00027480400703474965	+1	TP53,NF1,CTNNB1,PDGFRA,CDKN1A
POSITIVE REGULATION OF T CELL ACTIVATION%GOBP%GO:0050870	positive regulation of T cell activation	0.00027480400703474965	0.00027480400703474965	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS	IL6-mediated signaling events	0.00027480400703474965	0.00027480400703474965	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PTPN11
ANGIOGENESIS%WIKIPATHWAYS_20190610%WP1539%HOMO SAPIENS	http://www.wikipathways.org/instance/WP1539_r95042	0.00028983408769442696	0.00028983408769442696	+1	PIK3CA,AKT1,PDGFRA,FGFR2
ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.1	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	0.00028983408769442696	0.00028983408769442696	+1	EGFR,AKT1,CDKN1B,CCND1
RESPONSE TO OXYGEN LEVELS%GOBP%GO:0070482	response to oxygen levels	0.000315452545144778	0.000315452545144778	+1	TP53,VHL,NF1,NOTCH1,NFE2L2,AJUBA,MTOR,EP300,SMAD4
ENDOCARDIUM DEVELOPMENT%GOBP%GO:0003157	endocardium development	0.0003257190650445207	0.0003257190650445207	+1	NOTCH1,SMAD4,SOX17
MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.1	MET activates RAS signaling	0.0003257190650445207	0.0003257190650445207	+1	KRAS,NRAS,HGF
POSITIVE REGULATION OF TRANSCRIPTION BY RNA POLYMERASE III%GOBP%GO:0045945	positive regulation of transcription by RNA polymerase III	0.0003257190650445207	0.0003257190650445207	+1	CEBPA,AR,MTOR
CYTOSINE METHYLATION%WIKIPATHWAYS_20190610%WP3585%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3585_r94750	0.0003257190650445207	0.0003257190650445207	+1	IDH1,TET2,IDH2
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 69%6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.0003306438346195379	0.0003306438346195379	+1	TP53,NPM1,CDKN1B,EP300,CDKN1A
ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING	Angiopoietin receptor Tie2-mediated signaling	0.0003306438346195379	0.0003306438346195379	+1	PIK3CA,PIK3R1,AKT1,CDKN1A,PTPN11
MORPHOGENESIS OF A BRANCHING EPITHELIUM%GOBP%GO:0061138	morphogenesis of a branching epithelium	0.0003306438346195379	0.0003306438346195379	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
MALE SEX DIFFERENTIATION%GOBP%GO:0046661	male sex differentiation	0.0003306438346195379	0.0003306438346195379	+1	GATA3,TBX3,SOX9,WT1,KIT
VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM	VEGFR3 signaling in lymphatic endothelium	0.0003343180630924517	0.0003343180630924517	+1	PIK3CA,PIK3R1,MAP2K4,AKT1
TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY	TRAIL signaling pathway	0.0003343180630924517	0.0003343180630924517	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4
IL-7 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP205%HOMO SAPIENS	http://www.wikipathways.org/instance/WP205_r89854	0.0003343180630924517	0.0003343180630924517	+1	PIK3R1,AKT1,CDKN1B,CCND1
PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY	PID_LYMPH_ANGIOGENESIS_PATHWAY	0.0003343180630924517	0.0003343180630924517	+1	PIK3CA,PIK3R1,MAP2K4,AKT1
REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE%GOBP%GO:0060688	regulation of morphogenesis of a branching structure	0.0003343180630924517	0.0003343180630924517	+1	SOX9,HGF,LRRK2,FGFR2
SPINAL CORD INJURY%WIKIPATHWAYS_20190610%WP2431%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2431_r101932	0.0003396007405829356	0.0003396007405829356	+1	TP53,EGFR,RB1,SOX9,CDKN1B,TLR4,CCND1
IL2%NETPATH%IL2	IL2	0.0003396007405829356	0.0003396007405829356	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,MTOR,PTPN11
RESPONSE TO TRANSFORMING GROWTH FACTOR BETA%GOBP%GO:0071559	response to transforming growth factor beta	0.0003576941936461432	0.0003576941936461432	+1	SOX9,SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY	PID_ANGIOPOIETIN_RECEPTOR_PATHWAY	0.0003585889185021689	0.0003585889185021689	+1	PIK3CA,PIK3R1,AKT1,CDKN1A,PTPN11
LEPTIN%IOB%LEPTIN	Leptin	0.0003585889185021689	0.0003585889185021689	+1	PTEN,EGFR,PIK3R1,AKT1,PTPN11
TSH%NETPATH%TSH	TSH	0.000360913461946988	0.000360913461946988	+1	PIK3CA,PIK3R1,RB1,AKT1,CDKN1B,MTOR
CHROMOSOME SEGREGATION%GOBP%GO:0007059	chromosome segregation	0.0003662445397654671	0.0003662445397654671	+1	RB1,FBXW7,STAG2,BRCA1,PPP2R1A,SMC1A,SMC3,RAD21,ERCC2
EMBRYONIC ORGAN MORPHOGENESIS%GOBP%GO:0048562	embryonic organ morphogenesis	0.00037388483218072727	0.00037388483218072727	+1	NOTCH1,CTNNB1,SOX9,PDGFRA,FGFR2,TGFBR2,SOX17
PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY	PID_VEGFR1_PATHWAY	0.000383069126455539	0.000383069126455539	+1	PIK3CA,PIK3R1,AKT1,PTPN11
POSITIVE REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS%GOBP%GO:1901800	positive regulation of proteasomal protein catabolic process	0.000383069126455539	0.000383069126455539	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.1	Constitutive Signaling by AKT1 E17K in Cancer	0.000383069126455539	0.000383069126455539	+1	AKT1,CDKN1B,MTOR,CDKN1A
DAP12 SIGNALING%REACTOME%R-HSA-2424491.2	DAP12 signaling	0.000383069126455539	0.000383069126455539	+1	PIK3CA,KRAS,PIK3R1,NRAS
CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS	CXCR4-mediated signaling events	0.000383069126455539	0.000383069126455539	+1	PIK3CA,PIK3R1,AKT1,PIK3CG,MTOR,PTPN11
BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY	BIOCARTA_WNT_PATHWAY	0.000383069126455539	0.000383069126455539	+1	APC,CTNNB1,CCND1,SMAD4
ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.3	Activation of HOX genes during differentiation	0.0003865593160991431	0.0003865593160991431	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES%MSIGDB_C2%SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	0.0003865593160991431	0.0003865593160991431	+1	PIK3CA,PTEN,PIK3R1,CDKN2A,AKT1
INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE%GOBP%GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	0.0003865593160991431	0.0003865593160991431	+1	TP53,ATM,BRCA1,CHEK2,EP300
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.2	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.0003865593160991431	0.0003865593160991431	+1	CTCF,KDM6A,AJUBA,EP300,HIST1H2BD,NCOR1,EZH2
DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS%GOBP%GO:0060560	developmental growth involved in morphogenesis	0.0003865593160991431	0.0003865593160991431	+1	NOTCH1,CTNNB1,SOX9,FGFR2,USP9X
EPO%IOB%EPO	EPO	0.0004223669247798915	0.0004223669247798915	+1	PIK3R1,AKT1,BRAF,MTOR,PTPN11
OUTFLOW TRACT MORPHOGENESIS%GOBP%GO:0003151	outflow tract morphogenesis	0.0004223669247798915	0.0004223669247798915	+1	NOTCH1,FGFR2,SMAD4,TGFBR2,SOX17
TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY%GOBP%GO:0007179	transforming growth factor beta receptor signaling pathway	0.000430045546706237	0.000430045546706237	+1	SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
POSITIVE REGULATION OF LEUKOCYTE CELL-CELL ADHESION%GOBP%GO:1903039	positive regulation of leukocyte cell-cell adhesion	0.00043313509675263923	0.00043313509675263923	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS%GOBP%GO:2000136	regulation of cell proliferation involved in heart morphogenesis	0.0004333033092777968	0.0004333033092777968	+1	NOTCH1,CTNNB1,SMAD4
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME%R-HSA-9005891.2	Loss of function of MECP2 in Rett syndrome	0.0004333033092777968	0.0004333033092777968	+1	SIN3A,TBL1XR1,NCOR1
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-HSA-9028731.1	Activated NTRK2 signals through FRS2 and FRS3	0.0004333033092777968	0.0004333033092777968	+1	KRAS,NRAS,PTPN11
PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 69%9005895	Pervasive developmental disorders	0.0004333033092777968	0.0004333033092777968	+1	SIN3A,TBL1XR1,NCOR1
PROSTATE GLAND DEVELOPMENT%GOBP%GO:0030850	prostate gland development	0.0004333033092777968	0.0004333033092777968	+1	AR,SOX9,FGFR2
REGULATION OF HEART GROWTH%GOBP%GO:0060420	regulation of heart growth	0.000434024452259262	0.000434024452259262	+1	NOTCH1,WT1,ERBB4,FGFR2
AORTIC VALVE MORPHOGENESIS%GOBP%GO:0003180	aortic valve morphogenesis	0.000434024452259262	0.000434024452259262	+1	GATA3,RB1,NOTCH1,SOX9
VENTRICULAR SEPTUM MORPHOGENESIS%GOBP%GO:0060412	ventricular septum morphogenesis	0.000434024452259262	0.000434024452259262	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047	PDGF signaling pathway	0.0004406787470498315	0.0004406787470498315	+1	PIK3CA,PIK3R1,NRAS,BRAF,PIK3CG,ELF3,PDGFRA
REGULATION OF RESPONSE TO WOUNDING%GOBP%GO:1903034	regulation of response to wounding	0.0004406787470498315	0.0004406787470498315	+1	PTEN,CDKN1B,MTOR,TLR4,PDGFRA,FOXA2,CDKN1A
CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20190610%WP2406%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2406_r89157	0.0004524810424331043	0.0004524810424331043	+1	NOTCH1,KIT,PDGFRA,FOXA2,SOX17
POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY%GOBP%GO:0010518	positive regulation of phospholipase activity	0.0004524810424331043	0.0004524810424331043	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
NEGATIVE REGULATION OF CARDIAC MUSCLE TISSUE REGENERATION%GOBP%GO:1905179	negative regulation of cardiac muscle tissue regeneration	0.00047723775827916736	0.00047723775827916736	+1	CDKN1B,CDKN1A
ESTABLISHMENT OF PROTEIN-CONTAINING COMPLEX LOCALIZATION TO TELOMERE%GOBP%GO:0097695	establishment of protein-containing complex localization to telomere	0.00047723775827916736	0.00047723775827916736	+1	ATM,ATR
REGULATION OF TELOMERASE CATALYTIC CORE COMPLEX ASSEMBLY%GOBP%GO:1904882	regulation of telomerase catalytic core complex assembly	0.00047723775827916736	0.00047723775827916736	+1	ATM,ATR
POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY%GOBP%GO:0031334	positive regulation of protein complex assembly	0.00047723775827916736	0.00047723775827916736	+1	TP53,NAV3,CTNNB1,AJUBA,ATM,TLR4,TAF1,ATR,ERCC2
POSITIVE REGULATION OF TELOMERASE CATALYTIC CORE COMPLEX ASSEMBLY%GOBP%GO:1904884	positive regulation of telomerase catalytic core complex assembly	0.00047723775827916736	0.00047723775827916736	+1	ATM,ATR
PROSTATE GLAND MORPHOGENETIC GROWTH%GOBP%GO:0060737	prostate gland morphogenetic growth	0.00047723775827916736	0.00047723775827916736	+1	SOX9,FGFR2
REGULATION OF CARDIAC MUSCLE TISSUE REGENERATION%GOBP%GO:1905178	regulation of cardiac muscle tissue regeneration	0.00047723775827916736	0.00047723775827916736	+1	CDKN1B,CDKN1A
APOPTOSIS%WIKIPATHWAYS_20190610%WP254%HOMO SAPIENS	http://www.wikipathways.org/instance/WP254_r96952	0.00047723775827916736	0.00047723775827916736	+1	TP53,PIK3R1,CDKN2A,MAP3K1,MAP2K4,AKT1
ESTABLISHMENT OF RNA LOCALIZATION TO TELOMERE%GOBP%GO:0097694	establishment of RNA localization to telomere	0.00047723775827916736	0.00047723775827916736	+1	ATM,ATR
MORPHOGENESIS OF A BRANCHING STRUCTURE%GOBP%GO:0001763	morphogenesis of a branching structure	0.0004856901988344646	0.0004856901988344646	+1	CTNNB1,SOX9,WT1,FGFR2,TGFBR2
CARDIAC VENTRICLE MORPHOGENESIS%GOBP%GO:0003208	cardiac ventricle morphogenesis	0.0004856901988344646	0.0004856901988344646	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS	IL2-mediated signaling events	0.0004856901988344646	0.0004856901988344646	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE	Nephrin Neph1 signaling in the kidney podocyte	0.0004857690927258407	0.0004857690927258407	+1	PIK3CA,PIK3R1,MAP2K4,AKT1
PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY	PID_TRAIL_PATHWAY	0.0004857690927258407	0.0004857690927258407	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4
CELL FATE SPECIFICATION%GOBP%GO:0001708	cell fate specification	0.0004857690927258407	0.0004857690927258407	+1	APC,SOX9,FOXA2,SOX17
POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY%GOBP%GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	0.0004857690927258407	0.0004857690927258407	+1	FLT3,KIT,PDGFRA,FGFR3
DNA PACKAGING%GOBP%GO:0006323	DNA packaging	0.0004857690927258407	0.0004857690927258407	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD
BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS	BARD1 signaling events	0.0004857690927258407	0.0004857690927258407	+1	TP53,ATM,BRCA1,ATR
HAIR FOLLICLE DEVELOPMENT: CYTODIFFERENTIATION (PART 3 OF 3)%WIKIPATHWAYS_20190610%WP2840%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2840_r97324	0.0004945778507277133	0.0004945778507277133	+1	EGFR,GATA3,NOTCH1,CTNNB1,SOX9,SMAD4
RESPONSE TO IONIZING RADIATION%GOBP%GO:0010212	response to ionizing radiation	0.0004945778507277133	0.0004945778507277133	+1	TP53,STK11,ATM,BRCA1,CDKN1A,ATR
PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY	PID_IL2_1PATHWAY	0.0005231345768802367	0.0005231345768802367	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
WNT_SIGNALING%MSIGDB_C2%WNT_SIGNALING	WNT_SIGNALING	0.0005244096596238956	0.0005244096596238956	+1	APC,CTNNB1,EP300,CCND1,SOX17,PPP2R1A
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-HSA-9616222.1	Transcriptional regulation of granulopoiesis	0.0005244096596238956	0.0005244096596238956	+1	RUNX1,CEBPA,EP300,CDKN1A,CBFB,HIST1H2BD
REGULATION OF ORGANELLE ASSEMBLY%GOBP%GO:1902115	regulation of organelle assembly	0.0005420264598875703	0.0005420264598875703	+1	ARHGAP35,NPM1,STAG2,BRCA1,LRRK2,SMAD4,SMC1A,SMC3
REGULATION OF PROTEOLYSIS INVOLVED IN CELLULAR PROTEIN CATABOLIC PROCESS%GOBP%GO:1903050	regulation of proteolysis involved in cellular protein catabolic process	0.0005420264598875703	0.0005420264598875703	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
REGULATION OF HEART MORPHOGENESIS%GOBP%GO:2000826	regulation of heart morphogenesis	0.0005441406138862301	0.0005441406138862301	+1	NOTCH1,CTNNB1,SMAD4,TGFBR2
HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION%GOBP%GO:0002244	hematopoietic progenitor cell differentiation	0.0005441406138862301	0.0005441406138862301	+1	TP53,FLT3,KIT,PDGFRA
BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY	BIOCARTA_VEGF_PATHWAY	0.0005441406138862301	0.0005441406138862301	+1	PIK3CA,VHL,PIK3R1,PIK3CG
BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY	BIOCARTA_HDAC_PATHWAY	0.0005441406138862301	0.0005441406138862301	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY	IGF1 pathway	0.0005441406138862301	0.0005441406138862301	+1	PIK3CA,PIK3R1,AKT1,PTPN11
RESPONSE TO INTERLEUKIN-6%GOBP%GO:0070741	response to interleukin-6	0.0005441406138862301	0.0005441406138862301	+1	CEBPA,SMAD4,FOXA2,PTPN11
RAF ACTIVATION%REACTOME DATABASE ID RELEASE 69%5673000	RAF activation	0.0005441406138862301	0.0005441406138862301	+1	KRAS,NRAS,BRAF,PPP2R1A
PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY	PID_REELIN_PATHWAY	0.0005441406138862301	0.0005441406138862301	+1	PIK3CA,PIK3R1,AKT1,MAPK8IP1
PDGFR-BETA PATHWAY%WIKIPATHWAYS_20190610%WP3972%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3972_r92088	0.0005441406138862301	0.0005441406138862301	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4
VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS	VEGFR1 specific signals	0.0005441406138862301	0.0005441406138862301	+1	PIK3CA,PIK3R1,AKT1,PTPN11
REGULATION OF CIRCADIAN RHYTHM%GOBP%GO:0042752	regulation of circadian rhythm	0.0005467326970460105	0.0005467326970460105	+1	TP53,FBXW7,MTOR,USP9X,SIN3A,EZH2
POSITIVE REGULATION OF MESENCHYMAL CELL PROLIFERATION%GOBP%GO:0002053	positive regulation of mesenchymal cell proliferation	0.0005490807526906149	0.0005490807526906149	+1	SOX9,FGFR2,TGFBR2
CIRCADIAN BEHAVIOR%GOBP%GO:0048512	circadian behavior	0.0005490807526906149	0.0005490807526906149	+1	TP53,PTEN,NCOR1
RHYTHMIC BEHAVIOR%GOBP%GO:0007622	rhythmic behavior	0.0005490807526906149	0.0005490807526906149	+1	TP53,PTEN,NCOR1
ADIPOGENESIS%WIKIPATHWAYS_20190610%WP236%HOMO SAPIENS	http://www.wikipathways.org/instance/WP236_r97606	0.0005530750013668377	0.0005530750013668377	+1	GATA3,RB1,CTNNB1,CEBPA,CDKN1A,LIFR,NCOR1
HISTONE METHYLATION%GOBP%GO:0016571	histone methylation	0.0005530750013668377	0.0005530750013668377	+1	KDM6A,TET2,SETD2,NSD1,EZH2
REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE/THREONINE KINASE SIGNALING PATHWAY%GOBP%GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	0.0005709973599013589	0.0005709973599013589	+1	NOTCH1,STK11,EP300,SMAD4,TGFBR2,ACVR1B,ACVR2A,SMAD2
ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20190610%WP3915%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3915_r94801	0.0005775765982005009	0.0005775765982005009	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,AKT1,PIK3CG,MTOR
KIDNEY DEVELOPMENT%GOBP%GO:0001822	kidney development	0.0005775765982005009	0.0005775765982005009	+1	NF1,GATA3,SOX9,WT1,LRRK2,PDGFRA,FGFR2
IL-1 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP195%HOMO SAPIENS	http://www.wikipathways.org/instance/WP195_r89932	0.0005965102596298222	0.0005965102596298222	+1	PIK3R1,MAP3K1,MAP2K4,AKT1,PTPN11
TGF-BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20190610%WP560%HOMO SAPIENS	http://www.wikipathways.org/instance/WP560_r94936	0.0005965102596298222	0.0005965102596298222	+1	CTNNB1,EP300,SMAD4,TGFBR2,SMAD2
CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20190610%WP2795%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2795_r97631	0.0005965102596298222	0.0005965102596298222	+1	MAP3K1,MAP2K4,AKT1,MTOR,FGFR2
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 69%201681	TCF dependent signaling in response to WNT	0.0006038851622025169	0.0006038851622025169	+1	APC,CTNNB1,AKT1,SOX9,EP300,SOX17,PPP2R1A,HIST1H2BD,AXIN2
RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 69%8941326	RUNX2 regulates bone development	0.0006047382697855244	0.0006047382697855244	+1	RB1,AR,SMAD4,CBFB
NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY	Nectin adhesion pathway	0.0006047382697855244	0.0006047382697855244	+1	PIK3CA,PIK3R1,CTNNB1,CDH1
POSITIVE REGULATION OF GLUCOSE TRANSMEMBRANE TRANSPORT%GOBP%GO:0010828	positive regulation of glucose transmembrane transport	0.0006047382697855244	0.0006047382697855244	+1	PIK3R1,AKT1,BRAF,PTPN11
CELLULAR SENESCENCE%GOBP%GO:0090398	cellular senescence	0.0006047382697855244	0.0006047382697855244	+1	TP53,CDKN2A,TBX3,CDKN1A
PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY	PID_NECTIN_PATHWAY	0.0006047382697855244	0.0006047382697855244	+1	PIK3CA,PIK3R1,CTNNB1,CDH1
PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY	PID_IGF1_PATHWAY	0.0006047382697855244	0.0006047382697855244	+1	PIK3CA,PIK3R1,AKT1,PTPN11
AORTIC VALVE DEVELOPMENT%GOBP%GO:0003176	aortic valve development	0.0006047382697855244	0.0006047382697855244	+1	GATA3,RB1,NOTCH1,SOX9
PEPTIDYL-SERINE PHOSPHORYLATION%GOBP%GO:0018105	peptidyl-serine phosphorylation	0.000652178107015627	0.000652178107015627	+1	AKT1,ATM,MTOR,LRRK2,TGFBR2,TAF1,ATR
DEVELOPMENTAL GROWTH%GOBP%GO:0048589	developmental growth	0.000652178107015627	0.000652178107015627	+1	NOTCH1,CTNNB1,SOX9,ERBB4,FGFR2,USP9X,FGFR3
DNA CONFORMATION CHANGE%GOBP%GO:0071103	DNA conformation change	0.0006562626593446906	0.0006562626593446906	+1	TP53,CDKN2A,CTCF,NPM1,SOX9,ATRX,HIST1H1C,HIST1H2BD,ERCC2
PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY	PID_AURORA_A_PATHWAY	0.0006796298500795539	0.0006796298500795539	+1	TP53,AKT1,AJUBA,BRCA1
CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 69%389356	CD28 co-stimulation	0.0006796298500795539	0.0006796298500795539	+1	PIK3CA,PIK3R1,AKT1,MTOR
PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY	PID_AR_NONGENOMIC_PATHWAY	0.0006796298500795539	0.0006796298500795539	+1	PIK3CA,PIK3R1,AKT1,AR
GROWTH%GOBP%GO:0040007	growth	0.0006796298500795539	0.0006796298500795539	+1	NOTCH1,CTNNB1,SOX9,ERBB4,FGFR2,USP9X,FGFR3
PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY	PID_NEPHRIN_NEPH1_PATHWAY	0.0006796298500795539	0.0006796298500795539	+1	PIK3CA,PIK3R1,MAP2K4,AKT1
NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING	Nongenotropic Androgen signaling	0.0006796298500795539	0.0006796298500795539	+1	PIK3CA,PIK3R1,AKT1,AR
AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING	Aurora A signaling	0.0006796298500795539	0.0006796298500795539	+1	TP53,AKT1,AJUBA,BRCA1
IL5%NETPATH%IL5	IL5	0.0006840356291585183	0.0006840356291585183	+1	PIK3R1,CTNNB1,AKT1,PIK3CG,PTPN11
REGULATION OF T CELL ACTIVATION%GOBP%GO:0050863	regulation of T cell activation	0.0006907201758510479	0.0006907201758510479	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11,MAPK8IP1
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 69%9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.0006937549642727781	0.0006937549642727781	+1	PIK3CA,PIK3R1,PIK3CG
GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 69%179812	GRB2 events in EGFR signaling	0.0006937549642727781	0.0006937549642727781	+1	KRAS,EGFR,NRAS
BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY	BIOCARTA_TRKA_PATHWAY	0.0006937549642727781	0.0006937549642727781	+1	PIK3CA,PIK3R1,AKT1
G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.4	G2 M DNA damage checkpoint	0.0007002950923199988	0.0007002950923199988	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
VEGFA-VEGFR2 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP3888%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3888_r102004	0.0007079584281143182	0.0007079584281143182	+1	PIK3CA,PIK3R1,CTNNB1,MAP2K4,AKT1,MTOR,CCND1,PTPN11,EGR3
REGULATION OF PHOSPHOLIPID METABOLIC PROCESS%GOBP%GO:1903725	regulation of phospholipid metabolic process	0.0007315726414796073	0.0007315726414796073	+1	PIK3R1,FLT3,KIT,PDGFRA,FGFR3
INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0030518	intracellular steroid hormone receptor signaling pathway	0.0007315726414796073	0.0007315726414796073	+1	ARID1A,RB1,CTNNB1,AR,BRCA1
KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP304%HOMO SAPIENS	http://www.wikipathways.org/instance/WP304_r78799	0.0007315726414796073	0.0007315726414796073	+1	PIK3R1,AKT1,KIT,EP300,PTPN11
MAMMARY GLAND DEVELOPMENT PATHWAY - PREGNANCY AND LACTATION (STAGE 3 OF 4)%WIKIPATHWAYS_20190610%WP2817%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2817_r102410	0.0007547794810558985	0.0007547794810558985	+1	EGFR,CEBPA,ERBB4,CCND1
ERBB2 SIGNALING PATHWAY%GOBP%GO:0038128	ERBB2 signaling pathway	0.0007547794810558985	0.0007547794810558985	+1	PIK3CA,EGFR,PIK3R1,ERBB4
POSITIVE REGULATION OF LIPID KINASE ACTIVITY%GOBP%GO:0090218	positive regulation of lipid kinase activity	0.0007547794810558985	0.0007547794810558985	+1	FLT3,KIT,PDGFRA,FGFR3
RESPONSE TO ESTROGEN%GOBP%GO:0043627	response to estrogen	0.0007547794810558985	0.0007547794810558985	+1	GATA3,CRIPAK,BRCA1,EP300
VASCULOGENESIS%GOBP%GO:0001570	vasculogenesis	0.0007547794810558985	0.0007547794810558985	+1	NOTCH1,WT1,TGFBR2,SOX17
CARDIAC SEPTUM DEVELOPMENT%GOBP%GO:0003279	cardiac septum development	0.0007848862852150775	0.0007848862852150775	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
REGULATION OF CHROMATIN ORGANIZATION%GOBP%GO:1902275	regulation of chromatin organization	0.0007889794844388541	0.0007889794844388541	+1	CTNNB1,ATRX,BRCA1,HIST1H1C,SMAD4,SIN3A,NSD1
REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL%GOBP%GO:1903320	regulation of protein modification by small protein conjugation or removal	0.0008146209681929682	0.0008146209681929682	+1	PTEN,FBXW7,CTNNB1,AKT1,BRCA1,LRRK2,TAF1,RPL5
PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY	PID_NCADHERIN_PATHWAY	0.0008424241337026387	0.0008424241337026387	+1	PIK3CA,PIK3R1,CTNNB1,PTPN11
TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20190610%WP4204%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4204_r97134	0.0008424241337026387	0.0008424241337026387	+1	ARID1A,CDKN2A,RB1,EZH2
ONCOGENE INDUCED SENESCENCE%REACTOME%R-HSA-2559585.5	Oncogene Induced Senescence	0.0008424241337026387	0.0008424241337026387	+1	TP53,CDKN2A,RB1,CDKN2C
GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.5	GPVI-mediated activation cascade	0.0008424241337026387	0.0008424241337026387	+1	PIK3CA,PIK3R1,PIK3CG,PTPN11
MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20190610%WP3982%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3982_r96401	0.0008424241337026387	0.0008424241337026387	+1	TP53,PTEN,ATM,CHEK2
SIGNALING BY FGFR1 IN DISEASE%REACTOME%R-HSA-5655302.2	Signaling by FGFR1 in disease	0.0008424241337026387	0.0008424241337026387	+1	PIK3CA,KRAS,PIK3R1,NRAS
REGULATION OF EPITHELIAL CELL DIFFERENTIATION%GOBP%GO:0030856	regulation of epithelial cell differentiation	0.0008545012701284721	0.0008545012701284721	+1	GATA3,CTNNB1,RUNX1,SOX9,CBFB,VEZF1
REGULATION OF HISTONE MODIFICATION%GOBP%GO:0031056	regulation of histone modification	0.0008545012701284721	0.0008545012701284721	+1	CTNNB1,ATRX,BRCA1,SMAD4,SIN3A,NSD1
NEGATIVE REGULATION OF MYOBLAST DIFFERENTIATION%GOBP%GO:0045662	negative regulation of myoblast differentiation	0.000860260974653687	0.000860260974653687	+1	NOTCH1,TBX3,SOX9
SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-180336.2	SHC1 events in EGFR signaling	0.000860260974653687	0.000860260974653687	+1	KRAS,EGFR,NRAS
BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY	BIOCARTA_RB_PATHWAY	0.000860260974653687	0.000860260974653687	+1	TP53,RB1,ATM
PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 69%1963642	PI3K events in ERBB2 signaling	0.000860260974653687	0.000860260974653687	+1	PIK3CA,EGFR,PIK3R1
PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 69%5654710	PI-3K cascade:FGFR3	0.000860260974653687	0.000860260974653687	+1	PIK3CA,PIK3R1,PTPN11
POSITIVE REGULATION OF HISTONE H3-K4 METHYLATION%GOBP%GO:0051571	positive regulation of histone H3-K4 methylation	0.000860260974653687	0.000860260974653687	+1	CTNNB1,BRCA1,SMAD4
SA_REG_CASCADE_OF_CYCLIN_EXPR%MSIGDB_C2%SA_REG_CASCADE_OF_CYCLIN_EXPR	SA_REG_CASCADE_OF_CYCLIN_EXPR	0.000860260974653687	0.000860260974653687	+1	CDKN2A,CDKN1B,CCND1
POSITIVE REGULATION OF LIPASE ACTIVITY%GOBP%GO:0060193	positive regulation of lipase activity	0.0008902490207880979	0.0008902490207880979	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
LNCRNA INVOLVEMENT IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20190610%WP4258%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4258_r97136	0.0008902490207880979	0.0008902490207880979	+1	APC,CTNNB1,CCND1,SOX17,AXIN2,EZH2
REGULATION OF PHOSPHOLIPASE ACTIVITY%GOBP%GO:0010517	regulation of phospholipase activity	0.0008902490207880979	0.0008902490207880979	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP2380%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2380_r94178	0.0009122278845597398	0.0009122278845597398	+1	APC,PIK3R1,CTNNB1,MAP3K1,AKT1,MTOR,PTPN11
REGULATION OF MITOTIC NUCLEAR DIVISION%GOBP%GO:0007088	regulation of mitotic nuclear division	0.0009122278845597398	0.0009122278845597398	+1	APC,RB1,STAG2,ATM,ATRX,SMC1A,SMC3
POSITIVE REGULATION OF MAP KINASE ACTIVITY%GOBP%GO:0043406	positive regulation of MAP kinase activity	0.0009131607662069736	0.0009131607662069736	+1	EGFR,FLT3,MAP2K4,PIK3CG,TLR4,LRRK2,KIT,EZH2
ST_WNT_BETA_CATENIN_PATHWAY%MSIGDB_C2%ST_WNT_BETA_CATENIN_PATHWAY	ST_WNT_BETA_CATENIN_PATHWAY	0.0009205565888101773	0.0009205565888101773	+1	APC,CTNNB1,AKT1,AXIN2
EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS%GOBP%GO:0048704	embryonic skeletal system morphogenesis	0.0009205565888101773	0.0009205565888101773	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
SIGNALING OF HEPATOCYTE GROWTH FACTOR RECEPTOR%WIKIPATHWAYS_20190610%WP313%HOMO SAPIENS	http://www.wikipathways.org/instance/WP313_r97740	0.0009205565888101773	0.0009205565888101773	+1	PIK3CA,PTEN,HGF,PTPN11
NEGATIVE REGULATION OF CELLULAR RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1900408	negative regulation of cellular response to oxidative stress	0.0009205565888101773	0.0009205565888101773	+1	NFE2L2,AKT1,HGF,LRRK2
NEGATIVE REGULATION OF OXIDATIVE STRESS-INDUCED CELL DEATH%GOBP%GO:1903202	negative regulation of oxidative stress-induced cell death	0.0009205565888101773	0.0009205565888101773	+1	NFE2L2,AKT1,HGF,LRRK2
SIG_CD40PATHWAYMAP%MSIGDB_C2%SIG_CD40PATHWAYMAP	SIG_CD40PATHWAYMAP	0.0009205565888101773	0.0009205565888101773	+1	PIK3CA,PIK3R1,MAP2K4,MAPK8IP1
CELLULAR RESPONSE TO INORGANIC SUBSTANCE%GOBP%GO:0071241	cellular response to inorganic substance	0.0009415238844886633	0.0009415238844886633	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,ATRX,LRRK2
STEROID HORMONE MEDIATED SIGNALING PATHWAY%GOBP%GO:0043401	steroid hormone mediated signaling pathway	0.0009424505952191878	0.0009424505952191878	+1	ARID1A,RB1,CTNNB1,AR,BRCA1
CANONICAL WNT SIGNALING PATHWAY%GOBP%GO:0060070	canonical Wnt signaling pathway	0.0009424505952191878	0.0009424505952191878	+1	PTEN,APC,GATA3,CTNNB1,LRRK2
REGULATION OF STEM CELL DIFFERENTIATION%GOBP%GO:2000736	regulation of stem cell differentiation	0.0009746743727316584	0.0009746743727316584	+1	GATA3,NOTCH1,RUNX1,SOX9,PDGFRA,CBFB
TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS	TCR signaling in naive CD4+ T cells	0.0010089426137403414	0.0010089426137403414	+1	PTEN,KRAS,NRAS,AKT1,PTPN11
ST_FAS_SIGNALING_PATHWAY%MSIGDB_C2%ST_FAS_SIGNALING_PATHWAY	ST_FAS_SIGNALING_PATHWAY	0.0010089426137403414	0.0010089426137403414	+1	TP53,EGFR,MAP3K1,MAP2K4,MAPK8IP1
PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY	PID_BCR_5PATHWAY	0.0010089426137403414	0.0010089426137403414	+1	PIK3CA,PTEN,PIK3R1,MAP3K1,AKT1
SKELETAL SYSTEM MORPHOGENESIS%GOBP%GO:0048705	skeletal system morphogenesis	0.0010112139256449552	0.0010112139256449552	+1	CTNNB1,SOX9,PDGFRA,FGFR2,FGFR3,TGFBR2
FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY	FAS (CD95) signaling pathway	0.0010112139256449552	0.0010112139256449552	+1	PIK3CA,PIK3R1,MAP3K1,AKT1
ALPHA 6 BETA 4 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP244%HOMO SAPIENS	http://www.wikipathways.org/instance/WP244_r85199	0.0010112139256449552	0.0010112139256449552	+1	PIK3R1,AKT1,MTOR,PTPN11
ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS	ErbB4 signaling events	0.0010112139256449552	0.0010112139256449552	+1	PIK3CA,PIK3R1,ERBB4,NCOR1
PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY	PID_PI3KCI_AKT_PATHWAY	0.0010112139256449552	0.0010112139256449552	+1	AKT1,CDKN1B,MTOR,CDKN1A
CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT	Class I PI3K signaling events mediated by Akt	0.0010112139256449552	0.0010112139256449552	+1	AKT1,CDKN1B,MTOR,CDKN1A
POSITIVE REGULATION OF CELL CYCLE G1/S PHASE TRANSITION%GOBP%GO:1902808	positive regulation of cell cycle G1/S phase transition	0.0010112139256449552	0.0010112139256449552	+1	EGFR,AKT1,CCND1,EZH2
FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.2	FCERI mediated MAPK activation	0.0010112139256449552	0.0010112139256449552	+1	KRAS,MAP3K1,NRAS,MAP2K4
SEMI-LUNAR VALVE DEVELOPMENT%GOBP%GO:1905314	semi-lunar valve development	0.0010112139256449552	0.0010112139256449552	+1	GATA3,RB1,NOTCH1,SOX9
POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION%GOBP%GO:0060045	positive regulation of cardiac muscle cell proliferation	0.0010260233669524012	0.0010260233669524012	+1	NOTCH1,ERBB4,FGFR2
RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY	Ras signaling in the CD4+ TCR pathway	0.0010260233669524012	0.0010260233669524012	+1	KRAS,NRAS,BRAF
IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS	IL5-mediated signaling events	0.0010260233669524012	0.0010260233669524012	+1	PIK3CA,PIK3R1,PTPN11
BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY	BIOCARTA_PS1_PATHWAY	0.0010260233669524012	0.0010260233669524012	+1	APC,NOTCH1,CTNNB1
PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-HSA-8849471.2	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	0.0010260233669524012	0.0010260233669524012	+1	KRAS,ARHGAP35,NRAS
CARDIAC LEFT VENTRICLE MORPHOGENESIS%GOBP%GO:0003214	cardiac left ventricle morphogenesis	0.0010260233669524012	0.0010260233669524012	+1	NOTCH1,SMAD4,TGFBR2
PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY	PID_TCR_RAS_PATHWAY	0.0010260233669524012	0.0010260233669524012	+1	KRAS,NRAS,BRAF
CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20190610%WP4582%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4582_r104340	0.0010260233669524012	0.0010260233669524012	+1	PIK3CA,PIK3R1,PTPN11
PROTEIN LOCALIZATION TO CHROMOSOME, TELOMERIC REGION%GOBP%GO:0070198	protein localization to chromosome, telomeric region	0.0010260233669524012	0.0010260233669524012	+1	ATRX,BRCA2,ATR
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 69%6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.0010260233669524012	0.0010260233669524012	+1	TP53,CDKN1B,CDKN1A
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.3	AKT phosphorylates targets in the cytosol	0.0010260233669524012	0.0010260233669524012	+1	AKT1,CDKN1B,CDKN1A
PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY	PID_IL5_PATHWAY	0.0010260233669524012	0.0010260233669524012	+1	PIK3CA,PIK3R1,PTPN11
GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.3	GRB2 events in ERBB2 signaling	0.0010260233669524012	0.0010260233669524012	+1	KRAS,EGFR,NRAS
SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 69%1295596	Spry regulation of FGF signaling	0.0010260233669524012	0.0010260233669524012	+1	BRAF,PPP2R1A,PTPN11
NEGATIVE REGULATION OF AUTOPHAGY%GOBP%GO:0010507	negative regulation of autophagy	0.0010393309263948402	0.0010393309263948402	+1	PIK3CA,AKT1,HGF,MTOR,LRRK2
PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY	PID_TCR_PATHWAY	0.0010393309263948402	0.0010393309263948402	+1	PTEN,KRAS,NRAS,AKT1,PTPN11
PEPTIDYL-THREONINE PHOSPHORYLATION%GOBP%GO:0018107	peptidyl-threonine phosphorylation	0.0010393309263948402	0.0010393309263948402	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
PRADER-WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20190610%WP3998%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3998_r101993	0.0010393309263948402	0.0010393309263948402	+1	TP53,CDKN2A,RB1,CCND1,CDKN2C
MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY	mTOR signaling pathway	0.0010393309263948402	0.0010393309263948402	+1	KRAS,NRAS,AKT1,BRAF,MTOR
TOLL-LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP75%HOMO SAPIENS	http://www.wikipathways.org/instance/WP75_r102773	0.0010393309263948402	0.0010393309263948402	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PIK3CG,TLR4
POSITIVE REGULATION OF PROTEASOMAL UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	0.0010393309263948402	0.0010393309263948402	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY	BCR signaling pathway	0.0010393309263948402	0.0010393309263948402	+1	PIK3CA,PTEN,PIK3R1,MAP3K1,AKT1
POSITIVE REGULATION OF GROWTH%GOBP%GO:0045927	positive regulation of growth	0.00105747496000001	0.00105747496000001	+1	EGFR,NOTCH1,AKT1,WT1,ERBB4,FGFR2,H3F3C
HISTONE LYSINE METHYLATION%GOBP%GO:0034968	histone lysine methylation	0.001084053755693961	0.001084053755693961	+1	KDM6A,TET2,SETD2,EZH2
SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	0.001084053755693961	0.001084053755693961	+1	PIK3CA,PTEN,CDKN2A,AKT1
N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS	N-cadherin signaling events	0.001084053755693961	0.001084053755693961	+1	PIK3CA,PIK3R1,CTNNB1,PTPN11
MESENCHYME MORPHOGENESIS%GOBP%GO:0072132	mesenchyme morphogenesis	0.001084053755693961	0.001084053755693961	+1	NOTCH1,SOX9,TGFBR2,SMAD2
TYPE 2 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20190610%WP4241%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4241_r97131	0.001084053755693961	0.001084053755693961	+1	VHL,SETD2,EP300,CDKN1A
NEGATIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1902883	negative regulation of response to oxidative stress	0.001084053755693961	0.001084053755693961	+1	NFE2L2,AKT1,HGF,LRRK2
PI3K CASCADE%REACTOME%R-HSA-109704.5	PI3K Cascade	0.001084053755693961	0.001084053755693961	+1	PIK3CA,PIK3R1,FLT3,PTPN11
REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN%GOBP%GO:0042509	regulation of tyrosine phosphorylation of STAT protein	0.0011027659164220382	0.0011027659164220382	+1	FLT3,ERBB4,KIT,FGFR3,PPP2R1A
INTESTINAL EPITHELIAL STRUCTURE MAINTENANCE%GOBP%GO:0060729	intestinal epithelial structure maintenance	0.0011226504000480017	0.0011226504000480017	+1	SOX9,TLR4
LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 69%3304347	Loss of Function of SMAD4 in Cancer	0.0011226504000480017	0.0011226504000480017	+1	SMAD4,SMAD2
SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.2	SMAD2 3 MH2 Domain Mutants in Cancer	0.0011226504000480017	0.0011226504000480017	+1	SMAD4,SMAD2
NEGATIVE REGULATION OF MAMMARY GLAND EPITHELIAL CELL PROLIFERATION%GOBP%GO:0033600	negative regulation of mammary gland epithelial cell proliferation	0.0011226504000480017	0.0011226504000480017	+1	GATA3,BRCA2
PROSTATE GLAND EPITHELIUM MORPHOGENESIS%GOBP%GO:0060740	prostate gland epithelium morphogenesis	0.0011226504000480017	0.0011226504000480017	+1	SOX9,FGFR2
RESPONSE TO LITHIUM ION%GOBP%GO:0010226	response to lithium ion	0.0011226504000480017	0.0011226504000480017	+1	CDH1,CDKN1B
SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 69%3311021	SMAD4 MH2 Domain Mutants in Cancer	0.0011226504000480017	0.0011226504000480017	+1	SMAD4,SMAD2
E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS	E-cadherin signaling events	0.0011226504000480017	0.0011226504000480017	+1	CTNNB1,CDH1
FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS	FOXA transcription factor networks	0.0011226504000480017	0.0011226504000480017	+1	FOXA1,FOXA2
CELLULAR RESPONSE TO LITHIUM ION%GOBP%GO:0071285	cellular response to lithium ion	0.0011226504000480017	0.0011226504000480017	+1	CDH1,CDKN1B
RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 69%8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	0.0011226504000480017	0.0011226504000480017	+1	RUNX1,CBFB
REGULATION OF CELL PROLIFERATION INVOLVED IN HEART VALVE MORPHOGENESIS%GOBP%GO:0003250	regulation of cell proliferation involved in heart valve morphogenesis	0.0011226504000480017	0.0011226504000480017	+1	NOTCH1,SMAD4
APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006	Apoptosis signaling pathway	0.0011226504000480017	0.0011226504000480017	+1	TP53,PIK3CA,MAP3K1,MAP2K4,AKT1,PIK3CG
BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY	BIOCARTA_ALK_PATHWAY	0.0011750978079736706	0.0011750978079736706	+1	APC,CTNNB1,SMAD4,TGFBR2
ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY%MSIGDB_C2%ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	0.0011750978079736706	0.0011750978079736706	+1	PIK3CA,PTEN,CDKN2A,AKT1
PRION DISEASE PATHWAY%WIKIPATHWAYS_20190610%WP3995%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3995_r104288	0.0011750978079736706	0.0011750978079736706	+1	CTCF,EP300,SMC3,RAD21
RESPONSE TO ANTINEOPLASTIC AGENT%GOBP%GO:0097327	response to antineoplastic agent	0.0011750978079736706	0.0011750978079736706	+1	CTNNB1,CDH1,ATRX,BRCA1
REGULATION OF KIDNEY DEVELOPMENT%GOBP%GO:0090183	regulation of kidney development	0.0011750978079736706	0.0011750978079736706	+1	GATA3,CTNNB1,SOX9,WT1
REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS%GOBP%GO:1903362	regulation of cellular protein catabolic process	0.0011750978079736706	0.0011750978079736706	+1	PTEN,FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1,RPL5
REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0055024	regulation of cardiac muscle tissue development	0.0011750978079736706	0.0011750978079736706	+1	NOTCH1,ERBB4,FGFR2,SMAD4
T41 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358752.1	T41 mutants of beta-catenin aren't phosphorylated	0.0011843894064404673	0.0011843894064404673	+1	APC,CTNNB1,PPP2R1A
S37 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.1	S37 mutants of beta-catenin aren't phosphorylated	0.0011843894064404673	0.0011843894064404673	+1	APC,CTNNB1,PPP2R1A
NEGATIVE REGULATION OF HYDROGEN PEROXIDE-INDUCED CELL DEATH%GOBP%GO:1903206	negative regulation of hydrogen peroxide-induced cell death	0.0011843894064404673	0.0011843894064404673	+1	NFE2L2,HGF,LRRK2
REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2001185	regulation of CD8-positive, alpha-beta T cell activation	0.0011843894064404673	0.0011843894064404673	+1	RUNX1,CBFB,MAPK8IP1
EMBRYONIC CRANIAL SKELETON MORPHOGENESIS%GOBP%GO:0048701	embryonic cranial skeleton morphogenesis	0.0011843894064404673	0.0011843894064404673	+1	PDGFRA,FGFR2,TGFBR2
S33 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 69%5358747	S33 mutants of beta-catenin aren't phosphorylated	0.0011843894064404673	0.0011843894064404673	+1	APC,CTNNB1,PPP2R1A
S45 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 69%5358751	S45 mutants of beta-catenin aren't phosphorylated	0.0011843894064404673	0.0011843894064404673	+1	APC,CTNNB1,PPP2R1A
PEPTIDYL-SERINE MODIFICATION%GOBP%GO:0018209	peptidyl-serine modification	0.0011843894064404673	0.0011843894064404673	+1	AKT1,ATM,MTOR,LRRK2,TGFBR2,TAF1,ATR
POSITIVE REGULATION OF MESONEPHROS DEVELOPMENT%GOBP%GO:0061213	positive regulation of mesonephros development	0.0011843894064404673	0.0011843894064404673	+1	GATA3,SOX9,WT1
NEGATIVE REGULATION OF CELLULAR RESPONSE TO DRUG%GOBP%GO:2001039	negative regulation of cellular response to drug	0.0011843894064404673	0.0011843894064404673	+1	NFE2L2,HGF,LRRK2
PHYTOCHEMICAL ACTIVITY ON NRF2 TRANSCRIPTIONAL ACTIVATION%WIKIPATHWAYS_20190610%WP3%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3_r98703	0.0011843894064404673	0.0011843894064404673	+1	PIK3CA,KEAP1,NFE2L2
REGULATION OF MESENCHYMAL CELL PROLIFERATION%GOBP%GO:0010464	regulation of mesenchymal cell proliferation	0.0011843894064404673	0.0011843894064404673	+1	SOX9,FGFR2,TGFBR2
BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY	BIOCARTA_PITX2_PATHWAY	0.0011843894064404673	0.0011843894064404673	+1	APC,CTNNB1,EP300
PHOSPHORYLATION SITE MUTANTS OF CTNNB1 ARE NOT TARGETED TO THE PROTEASOME BY THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 69%4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	0.0011843894064404673	0.0011843894064404673	+1	APC,CTNNB1,PPP2R1A
FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 69%5654706	FRS-mediated FGFR3 signaling	0.0011843894064404673	0.0011843894064404673	+1	KRAS,NRAS,PTPN11
PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 69%5654689	PI-3K cascade:FGFR1	0.0011843894064404673	0.0011843894064404673	+1	PIK3CA,PIK3R1,PTPN11
NEGATIVE REGULATION OF RESPONSE TO REACTIVE OXYGEN SPECIES%GOBP%GO:1901032	negative regulation of response to reactive oxygen species	0.0011843894064404673	0.0011843894064404673	+1	NFE2L2,HGF,LRRK2
NEGATIVE REGULATION OF VASCULAR SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:1904706	negative regulation of vascular smooth muscle cell proliferation	0.0011843894064404673	0.0011843894064404673	+1	PTEN,CDKN1B,CDKN1A
MISSPLICED GSK3BETA MUTANTS STABILIZE BETA-CATENIN%REACTOME DATABASE ID RELEASE 69%5339716	Misspliced GSK3beta mutants stabilize beta-catenin	0.0011843894064404673	0.0011843894064404673	+1	APC,CTNNB1,PPP2R1A
PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY	PID_MTOR_4PATHWAY	0.0012015381382718365	0.0012015381382718365	+1	KRAS,NRAS,AKT1,BRAF,MTOR
IL1%NETPATH%IL1	IL1	0.0012015381382718365	0.0012015381382718365	+1	PIK3R1,RB1,MAP2K4,AKT1,PTPN11
ANGIOGENESIS%GOBP%GO:0001525	angiogenesis	0.0012128313717535526	0.0012128313717535526	+1	CTNNB1,AKT1,PDGFRA,FGFR2,TGFBR2,SOX17,EGR3
REGULATION OF NUCLEAR DIVISION%GOBP%GO:0051783	regulation of nuclear division	0.0012128313717535526	0.0012128313717535526	+1	APC,RB1,STAG2,ATM,ATRX,SMC1A,SMC3
MESENCHYMAL CELL DIFFERENTIATION%GOBP%GO:0048762	mesenchymal cell differentiation	0.0012481817479168841	0.0012481817479168841	+1	NOTCH1,CTNNB1,SOX9,HGF,ERBB4,FGFR2
HEART MORPHOGENESIS%GOBP%GO:0003007	heart morphogenesis	0.0012589196839685518	0.0012589196839685518	+1	GATA3,NOTCH1,SOX9,FGFR2,SMAD4,TGFBR2,SOX17
PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY	PID_FAS_PATHWAY	0.0012595036636776015	0.0012595036636776015	+1	PIK3CA,PIK3R1,MAP3K1,AKT1
BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY	BIOCARTA_IL2RB_PATHWAY	0.0012595036636776015	0.0012595036636776015	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY	PID_ERBB4_PATHWAY	0.0012595036636776015	0.0012595036636776015	+1	PIK3CA,PIK3R1,ERBB4,NCOR1
POSITIVE REGULATION OF TYPE I INTERFERON PRODUCTION%GOBP%GO:0032481	positive regulation of type I interferon production	0.0012714576278116396	0.0012714576278116396	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
CARDIOCYTE DIFFERENTIATION%GOBP%GO:0035051	cardiocyte differentiation	0.0012714576278116396	0.0012714576278116396	+1	NOTCH1,WT1,PDGFRA,SMAD4,SOX17
POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS%GOBP%GO:2000379	positive regulation of reactive oxygen species metabolic process	0.0013559384634090886	0.0013559384634090886	+1	TP53,AKT1,TLR4,TGFBR2,CDKN1A
GONAD DEVELOPMENT%GOBP%GO:0008406	gonad development	0.0013559384634090886	0.0013559384634090886	+1	GATA3,SOX9,WT1,KIT,PDGFRA
ST_JNK_MAPK_PATHWAY%MSIGDB_C2%ST_JNK_MAPK_PATHWAY	ST_JNK_MAPK_PATHWAY	0.0013794314932842138	0.0013794314932842138	+1	TP53,MAP3K1,MAP2K4,AKT1
DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.1	DAP12 interactions	0.0013794314932842138	0.0013794314932842138	+1	PIK3CA,KRAS,PIK3R1,NRAS
PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 69%5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.0013794314932842138	0.0013794314932842138	+1	ATM,BRCA1,BRCA2,ATR
EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING	EPHB forward signaling	0.0013794314932842138	0.0013794314932842138	+1	PIK3CA,KRAS,PIK3R1,NRAS
REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 69%186712	Regulation of beta-cell development	0.0013794314932842138	0.0013794314932842138	+1	NOTCH1,AKT1,EP300,FOXA2
REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE-ANAPHASE TRANSITION%WIKIPATHWAYS_20190610%WP4240%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4240_r96623	0.0014030250745705984	0.0014030250745705984	+1	SMC1A,SMC3,RAD21
REGULATION OF NEUROBLAST PROLIFERATION%GOBP%GO:1902692	regulation of neuroblast proliferation	0.0014030250745705984	0.0014030250745705984	+1	NF1,CTNNB1,LRRK2
REGULATION OF PRODUCTION OF MIRNAS INVOLVED IN GENE SILENCING BY MIRNA%GOBP%GO:1903798	regulation of production of miRNAs involved in gene silencing by miRNA	0.0014030250745705984	0.0014030250745705984	+1	TP53,EGFR,NCOR1
SYMPATHETIC NERVOUS SYSTEM DEVELOPMENT%GOBP%GO:0048485	sympathetic nervous system development	0.0014030250745705984	0.0014030250745705984	+1	NF1,GATA3,CTNNB1
BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY	BIOCARTA_CDC42RAC_PATHWAY	0.0014030250745705984	0.0014030250745705984	+1	PIK3CA,PIK3R1,PDGFRA
POSITIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN SERINE/THREONINE KINASE ACTIVITY%GOBP%GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	0.0014030250745705984	0.0014030250745705984	+1	EGFR,AKT1,CCND1
FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 69%2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.0014030250745705984	0.0014030250745705984	+1	TP53,RB1,HIST1H1C
INTERLEUKIN-6-MEDIATED SIGNALING PATHWAY%GOBP%GO:0070102	interleukin-6-mediated signaling pathway	0.0014030250745705984	0.0014030250745705984	+1	CEBPA,SMAD4,PTPN11
REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO STRESS%GOBP%GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	0.0014078306626782288	0.0014078306626782288	+1	TP53,VHL,NOTCH1,NFE2L2,EP300,TAF1
POSITIVE REGULATION OF JAK-STAT CASCADE%GOBP%GO:0046427	positive regulation of JAK-STAT cascade	0.0014197090827711295	0.0014197090827711295	+1	NOTCH1,FLT3,ERBB4,KIT,FGFR3
SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 69%170834	Signaling by TGF-beta Receptor Complex	0.0014197090827711295	0.0014197090827711295	+1	SMAD4,USP9X,TGFBR2,NCOR1,SMAD2
NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS%GOBP%GO:0031330	negative regulation of cellular catabolic process	0.001429441093372878	0.001429441093372878	+1	PIK3CA,AKT1,HGF,MTOR,LRRK2,TAF1,RPL5,AXIN2
NEGATIVE REGULATION OF CHROMOSOME ORGANIZATION%GOBP%GO:2001251	negative regulation of chromosome organization	0.0014701938508192378	0.0014701938508192378	+1	APC,ATM,ATRX,BRCA1,HIST1H1C,SIN3A
BCR%NETPATH%BCR	BCR	0.001479038970359394	0.001479038970359394	+1	PIK3R1,RB1,CTNNB1,AKT1,BRAF,PIK3CG,PTPN11
HALLMARK_APOPTOSIS%MSIGDB_C2%HALLMARK_APOPTOSIS	HALLMARK_APOPTOSIS	0.001479038970359394	0.001479038970359394	+1	CTNNB1,CDKN1B,HGF,BRCA1,CCND1,CDKN1A,EGR3
PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY	PID_EPHB_FWD_PATHWAY	0.0014865519128622491	0.0014865519128622491	+1	PIK3CA,KRAS,PIK3R1,NRAS
NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 69%5675221	Negative regulation of MAPK pathway	0.0014865519128622491	0.0014865519128622491	+1	KRAS,NRAS,BRAF,PPP2R1A
PDGF PATHWAY%WIKIPATHWAYS_20190610%WP2526%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2526_r103637	0.0014865519128622491	0.0014865519128622491	+1	PIK3R1,MAP3K1,MAP2K4,PTPN11
NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20190610%WP4564%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4564_r103712	0.0014865519128622491	0.0014865519128622491	+1	PIK3CA,AKT1,PIK3CG,EPHB6
POSITIVE REGULATION OF PHOSPHOLIPID METABOLIC PROCESS%GOBP%GO:1903727	positive regulation of phospholipid metabolic process	0.0014865519128622491	0.0014865519128622491	+1	FLT3,KIT,PDGFRA,FGFR3
DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS%GOBP%GO:0045137	development of primary sexual characteristics	0.0014945270129303116	0.0014945270129303116	+1	GATA3,SOX9,WT1,KIT,PDGFRA
CARDIAC VENTRICLE DEVELOPMENT%GOBP%GO:0003231	cardiac ventricle development	0.0014945270129303116	0.0014945270129303116	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
POSITIVE REGULATION OF LIPID METABOLIC PROCESS%GOBP%GO:0045834	positive regulation of lipid metabolic process	0.001523468718657248	0.001523468718657248	+1	FLT3,AKT1,MTOR,KIT,PDGFRA,FGFR3
PEPTIDYL-THREONINE MODIFICATION%GOBP%GO:0018210	peptidyl-threonine modification	0.0015890932845580986	0.0015890932845580986	+1	AKT1,LRRK2,TGFBR2,TAF1,ACVR1B
KIDNEY MORPHOGENESIS%GOBP%GO:0060993	kidney morphogenesis	0.0016236131998881155	0.0016236131998881155	+1	GATA3,SOX9,WT1,LRRK2
STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION	Stabilization and expansion of the E-cadherin adherens junction	0.0016236131998881155	0.0016236131998881155	+1	EGFR,CTNNB1,CDH1,HGF
OXIDATIVE DAMAGE%WIKIPATHWAYS_20190610%WP3941%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3941_r94696	0.0016236131998881155	0.0016236131998881155	+1	MAP3K1,MAP2K4,CDKN1B,CDKN1A
CELLULAR RESPONSE TO GAMMA RADIATION%GOBP%GO:0071480	cellular response to gamma radiation	0.001631711526990198	0.001631711526990198	+1	TP53,ATM,ATR
POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE GROWTH%GOBP%GO:0055023	positive regulation of cardiac muscle tissue growth	0.001631711526990198	0.001631711526990198	+1	NOTCH1,ERBB4,FGFR2
CANONICAL AND NON-CANONICAL TGF-B SIGNALING%WIKIPATHWAYS_20190610%WP3874%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3874_r89272	0.001631711526990198	0.001631711526990198	+1	SMAD4,TGFBR2,SMAD2
SA_TRKA_RECEPTOR%MSIGDB_C2%SA_TRKA_RECEPTOR	SA_TRKA_RECEPTOR	0.001631711526990198	0.001631711526990198	+1	PIK3CA,AKT1,CDKN1A
REGULATION OF PRODUCTION OF SMALL RNA INVOLVED IN GENE SILENCING BY RNA%GOBP%GO:0070920	regulation of production of small RNA involved in gene silencing by RNA	0.001631711526990198	0.001631711526990198	+1	TP53,EGFR,NCOR1
SA_PTEN_PATHWAY%MSIGDB_C2%SA_PTEN_PATHWAY	SA_PTEN_PATHWAY	0.001631711526990198	0.001631711526990198	+1	PIK3CA,PTEN,AKT1
AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20190610%WP3678%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3678_r90110	0.001631711526990198	0.001631711526990198	+1	VHL,NOTCH1,PIK3CG
PI-3K CASCADE:FGFR4%REACTOME%R-HSA-5654720.2	PI-3K cascade:FGFR4	0.001631711526990198	0.001631711526990198	+1	PIK3CA,PIK3R1,PTPN11
PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY	PID_SMAD2_3PATHWAY	0.001631711526990198	0.001631711526990198	+1	MAP3K1,SMAD4,SMAD2
BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 69%196299	Beta-catenin phosphorylation cascade	0.001631711526990198	0.001631711526990198	+1	APC,CTNNB1,PPP2R1A
GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.1	Gastrin-CREB signalling pathway via PKC and MAPK	0.001631711526990198	0.001631711526990198	+1	KRAS,EGFR,NRAS
FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 69%5654693	FRS-mediated FGFR1 signaling	0.001631711526990198	0.001631711526990198	+1	KRAS,NRAS,PTPN11
POSITIVE REGULATION OF STAT CASCADE%GOBP%GO:1904894	positive regulation of STAT cascade	0.0016600232646313958	0.0016600232646313958	+1	NOTCH1,FLT3,ERBB4,KIT,FGFR3
RHYTHMIC PROCESS%GOBP%GO:0048511	rhythmic process	0.001715802843421596	0.001715802843421596	+1	TP53,PTEN,PDGFRA,EP300,EGR3,NCOR1
REGULATION OF PROTEIN UBIQUITINATION%GOBP%GO:0031396	regulation of protein ubiquitination	0.001725197169603763	0.001725197169603763	+1	PTEN,FBXW7,AKT1,BRCA1,LRRK2,TAF1,RPL5
CHEMOKINE SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP3929%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3929_r90949	0.001725197169603763	0.001725197169603763	+1	PIK3CA,KRAS,PIK3R1,NRAS,AKT1,BRAF,PIK3CG
LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS	LKB1 signaling events	0.0017418648768824693	0.0017418648768824693	+1	TP53,STK11,MTOR,SMAD4
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 69%5693579	Homologous DNA Pairing and Strand Exchange	0.0017418648768824693	0.0017418648768824693	+1	ATM,BRCA1,BRCA2,ATR
HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDB_C2%HALLMARK_WNT_BETA_CATENIN_SIGNALING	HALLMARK_WNT_BETA_CATENIN_SIGNALING	0.0017418648768824693	0.0017418648768824693	+1	TP53,NOTCH1,CTNNB1,AXIN2
PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY	PID_ECADHERIN_STABILIZATION_PATHWAY	0.0017418648768824693	0.0017418648768824693	+1	EGFR,CTNNB1,CDH1,HGF
NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION%GOBP%GO:0050680	negative regulation of epithelial cell proliferation	0.0017473378643379672	0.0017473378643379672	+1	NF1,GATA3,FBXW7,SOX9,BRCA2
REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:0048660	regulation of smooth muscle cell proliferation	0.0017473378643379672	0.0017473378643379672	+1	PTEN,CTNNB1,AKT1,CDKN1B,CDKN1A
CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS%GOBP%GO:0031668	cellular response to extracellular stimulus	0.001775019111988152	0.001775019111988152	+1	TP53,ARHGAP35,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
REGULATION OF DNA-TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS%GOBP%GO:0043620	regulation of DNA-templated transcription in response to stress	0.0017753514622497937	0.0017753514622497937	+1	TP53,VHL,NOTCH1,NFE2L2,EP300,TAF1
CHORDATE EMBRYONIC DEVELOPMENT%GOBP%GO:0043009	chordate embryonic development	0.001834444413075617	0.001834444413075617	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001234	negative regulation of apoptotic signaling pathway	0.001834444413075617	0.001834444413075617	+1	RB1,NFE2L2,AKT1,AR,HGF,BRCA1,LRRK2
CARDIAC CHAMBER MORPHOGENESIS%GOBP%GO:0003206	cardiac chamber morphogenesis	0.0018463383956725792	0.0018463383956725792	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
REGULATION OF HISTONE H3-K4 METHYLATION%GOBP%GO:0051569	regulation of histone H3-K4 methylation	0.001882197379731773	0.001882197379731773	+1	CTNNB1,BRCA1,SMAD4
PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 69%5654695	PI-3K cascade:FGFR2	0.001882197379731773	0.001882197379731773	+1	PIK3CA,PIK3R1,PTPN11
INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY	Insulin Pathway	0.001882197379731773	0.001882197379731773	+1	PIK3CA,PIK3R1,AKT1,PTPN11
INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20190610%WP4301%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4301_r97800	0.001882197379731773	0.001882197379731773	+1	KRAS,NRAS,BRAF
METANEPHRIC NEPHRON DEVELOPMENT%GOBP%GO:0072210	metanephric nephron development	0.001882197379731773	0.001882197379731773	+1	SOX9,WT1,PDGFRA
BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY	BIOCARTA_NGF_PATHWAY	0.001882197379731773	0.001882197379731773	+1	PIK3CA,PIK3R1,PIK3CG
PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY	PID_BETA_CATENIN_DEG_PATHWAY	0.001882197379731773	0.001882197379731773	+1	APC,CTNNB1,AXIN2
DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN	Degradation of beta catenin	0.001882197379731773	0.001882197379731773	+1	APC,CTNNB1,AXIN2
SECONDARY PALATE DEVELOPMENT%GOBP%GO:0062009	secondary palate development	0.001882197379731773	0.001882197379731773	+1	SMAD4,TGFBR2,SMAD2
REGULATION OF MESONEPHROS DEVELOPMENT%GOBP%GO:0061217	regulation of mesonephros development	0.001882197379731773	0.001882197379731773	+1	GATA3,SOX9,WT1
IL-6 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP364%HOMO SAPIENS	http://www.wikipathways.org/instance/WP364_r89832	0.001882197379731773	0.001882197379731773	+1	PIK3R1,MAP2K4,AKT1,PTPN11
REGULATION OF HYDROGEN PEROXIDE-INDUCED CELL DEATH%GOBP%GO:1903205	regulation of hydrogen peroxide-induced cell death	0.001882197379731773	0.001882197379731773	+1	NFE2L2,HGF,LRRK2
NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20190610%WP4565%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4565_r103714	0.001882197379731773	0.001882197379731773	+1	PIK3CA,AKT1,PIK3CG,EPHB6
POSITIVE REGULATION OF DNA BINDING%GOBP%GO:0043388	positive regulation of DNA binding	0.001882197379731773	0.001882197379731773	+1	GATA3,RB1,CTNNB1,EP300
PROSTATE GLAND MORPHOGENESIS%GOBP%GO:0060512	prostate gland morphogenesis	0.0019139962334856233	0.0019139962334856233	+1	SOX9,FGFR2
OTIC VESICLE FORMATION%GOBP%GO:0030916	otic vesicle formation	0.0019139962334856233	0.0019139962334856233	+1	SOX9,FGFR2
BRANCH ELONGATION OF AN EPITHELIUM%GOBP%GO:0060602	branch elongation of an epithelium	0.0019139962334856233	0.0019139962334856233	+1	SOX9,FGFR2
P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK	p73 transcription factor network	0.0019139962334856233	0.0019139962334856233	+1	RB1,WT1,EP300,BRCA2,CDKN1A
POSITIVE REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	0.0019139962334856233	0.0019139962334856233	+1	RUNX1,CBFB
TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 69%69560	Transcriptional activation of p53 responsive genes	0.0019139962334856233	0.0019139962334856233	+1	TP53,CDKN1A
MONOUBIQUITINATED HISTONE DEUBIQUITINATION%GOBP%GO:0035521	monoubiquitinated histone deubiquitination	0.0019139962334856233	0.0019139962334856233	+1	BAP1,ASXL1
PROSTATE GLAND GROWTH%GOBP%GO:0060736	prostate gland growth	0.0019139962334856233	0.0019139962334856233	+1	SOX9,FGFR2
MONOUBIQUITINATED HISTONE H2A DEUBIQUITINATION%GOBP%GO:0035522	monoubiquitinated histone H2A deubiquitination	0.0019139962334856233	0.0019139962334856233	+1	BAP1,ASXL1
FOREBRAIN MORPHOGENESIS%GOBP%GO:0048853	forebrain morphogenesis	0.0019139962334856233	0.0019139962334856233	+1	PTEN,NF1
OTIC VESICLE MORPHOGENESIS%GOBP%GO:0071600	otic vesicle morphogenesis	0.0019139962334856233	0.0019139962334856233	+1	SOX9,FGFR2
MALE GENITALIA DEVELOPMENT%GOBP%GO:0030539	male genitalia development	0.0019139962334856233	0.0019139962334856233	+1	TBX3,WT1
PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY	PID_P73PATHWAY	0.0019139962334856233	0.0019139962334856233	+1	RB1,WT1,EP300,BRCA2,CDKN1A
TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.3	Transcriptional activation of cell cycle inhibitor p21	0.0019139962334856233	0.0019139962334856233	+1	TP53,CDKN1A
MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.1	MET activates PTPN11	0.0019139962334856233	0.0019139962334856233	+1	HGF,PTPN11
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 69%2173793	Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer	0.001998158508484057	0.001998158508484057	+1	SMAD4,USP9X,NCOR1,SMAD2
MALE GONAD DEVELOPMENT%GOBP%GO:0008584	male gonad development	0.001998158508484057	0.001998158508484057	+1	GATA3,SOX9,WT1,KIT
APOPTOSIS%REACTOME%R-HSA-109581.3	Apoptosis	0.0021113069627009644	0.0021113069627009644	+1	TP53,APC,CTNNB1,CDH1,AKT1,TLR4,HIST1H1C
RESPONSE TO ALCOHOL%GOBP%GO:0097305	response to alcohol	0.0021235494253529705	0.0021235494253529705	+1	CTNNB1,CDH1,BRCA1,TGFBR2,SMAD2
SISTER CHROMATID SEGREGATION%GOBP%GO:0000819	sister chromatid segregation	0.00212406856421745	0.00212406856421745	+1	RB1,FBXW7,STAG2,SMC1A,SMC3,RAD21
OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 69%2559580	Oxidative Stress Induced Senescence	0.00212406856421745	0.00212406856421745	+1	TP53,CDKN2A,MAP2K4,HIST1H2BD,CDKN2C,EZH2
POSITIVE REGULATION OF CYCLIN-DEPENDENT PROTEIN KINASE ACTIVITY%GOBP%GO:1904031	positive regulation of cyclin-dependent protein kinase activity	0.002125014653065212	0.002125014653065212	+1	EGFR,AKT1,CCND1
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 69%2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.002125014653065212	0.002125014653065212	+1	NOTCH1,EP300,TBL1XR1,NCOR1
BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY	BIOCARTA_TID_PATHWAY	0.002125014653065212	0.002125014653065212	+1	TP53,RB1,WT1
PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY	PID_EPHA2_FWD_PATHWAY	0.002125014653065212	0.002125014653065212	+1	PIK3CA,PIK3R1,ARHGAP35
DEVELOPMENT OF PRIMARY MALE SEXUAL CHARACTERISTICS%GOBP%GO:0046546	development of primary male sexual characteristics	0.002125014653065212	0.002125014653065212	+1	GATA3,SOX9,WT1,KIT
BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY	BIOCARTA_CTLA4_PATHWAY	0.002125014653065212	0.002125014653065212	+1	PIK3CA,PIK3R1,PTPN11
NEGATIVE REGULATION OF ANIMAL ORGAN MORPHOGENESIS%GOBP%GO:0110111	negative regulation of animal organ morphogenesis	0.002125014653065212	0.002125014653065212	+1	GATA3,NOTCH1,FBXW7
GENITALIA DEVELOPMENT%GOBP%GO:0048806	genitalia development	0.002125014653065212	0.002125014653065212	+1	TBX3,WT1,PTPN11
SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.4	SHC1 events in ERBB2 signaling	0.002125014653065212	0.002125014653065212	+1	KRAS,EGFR,NRAS
FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 69%5654712	FRS-mediated FGFR4 signaling	0.002125014653065212	0.002125014653065212	+1	KRAS,NRAS,PTPN11
PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY	PID_HIF1A_PATHWAY	0.002125014653065212	0.002125014653065212	+1	TP53,VHL,CDKN2A
EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING	EPHA2 forward signaling	0.002125014653065212	0.002125014653065212	+1	PIK3CA,PIK3R1,ARHGAP35
NEGATIVE REGULATION OF RESPONSE TO DRUG%GOBP%GO:2001024	negative regulation of response to drug	0.002125014653065212	0.002125014653065212	+1	NFE2L2,HGF,LRRK2
EMBRYONIC SKELETAL SYSTEM DEVELOPMENT%GOBP%GO:0048706	embryonic skeletal system development	0.002125014653065212	0.002125014653065212	+1	CTNNB1,PDGFRA,FGFR2,TGFBR2
HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.002125014653065212	0.002125014653065212	+1	TP53,VHL,CDKN2A
REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING	Regulation of cytoplasmic and nuclear SMAD2 3 signaling	0.002125014653065212	0.002125014653065212	+1	MAP3K1,SMAD4,SMAD2
PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY	PID_INSULIN_PATHWAY	0.002125014653065212	0.002125014653065212	+1	PIK3CA,PIK3R1,AKT1,PTPN11
G-CSF%IOB%G-CSF	G-CSF	0.002125014653065212	0.002125014653065212	+1	NOTCH1,AKT1,CDKN1B,PTPN11
REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION%GOBP%GO:0060043	regulation of cardiac muscle cell proliferation	0.002125014653065212	0.002125014653065212	+1	NOTCH1,ERBB4,FGFR2
REGULATION OF LEUKOCYTE CELL-CELL ADHESION%GOBP%GO:1903037	regulation of leukocyte cell-cell adhesion	0.002150184199228686	0.002150184199228686	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
REGULATION OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE%GOBP%GO:1903076	regulation of protein localization to plasma membrane	0.00219271053916631	0.00219271053916631	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 69%5357801	Programmed Cell Death	0.0022788088096874115	0.0022788088096874115	+1	TP53,APC,CTNNB1,CDH1,AKT1,TLR4,HIST1H1C
PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING	Presenilin action in Notch and Wnt signaling	0.0022859176613046627	0.0022859176613046627	+1	APC,NOTCH1,CTNNB1,CCND1
T CELL COSTIMULATION%GOBP%GO:0031295	T cell costimulation	0.0022859176613046627	0.0022859176613046627	+1	PIK3CA,PIK3R1,AKT1,PTPN11
CARDIAC SEPTUM MORPHOGENESIS%GOBP%GO:0060411	cardiac septum morphogenesis	0.0022859176613046627	0.0022859176613046627	+1	NOTCH1,FGFR2,SMAD4,TGFBR2
BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY	BIOCARTA_KERATINOCYTE_PATHWAY	0.0022859176613046627	0.0022859176613046627	+1	EGFR,MAP3K1,MAP2K4,CEBPA
ORGAN GROWTH%GOBP%GO:0035265	organ growth	0.0022859176613046627	0.0022859176613046627	+1	NOTCH1,SOX9,FGFR2,FGFR3
ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20190610%WP4535%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4535_r104294	0.0022859176613046627	0.0022859176613046627	+1	KRAS,NRAS,SMAD4,SMAD2
AXIS SPECIFICATION%GOBP%GO:0009798	axis specification	0.0022859176613046627	0.0022859176613046627	+1	TBX3,WT1,FOXA2,SMAD2
PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY	PID_PS1_PATHWAY	0.0022859176613046627	0.0022859176613046627	+1	APC,NOTCH1,CTNNB1,CCND1
GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK	Glucocorticoid receptor regulatory network	0.002293112070602677	0.002293112070602677	+1	TP53,GATA3,AKT1,EP300,CDKN1A
PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY	PID_REG_GR_PATHWAY	0.002293112070602677	0.002293112070602677	+1	TP53,GATA3,AKT1,EP300,CDKN1A
PROTEIN-DNA COMPLEX ASSEMBLY%GOBP%GO:0065004	protein-DNA complex assembly	0.0023300953825849268	0.0023300953825849268	+1	TP53,NPM1,SOX9,ATRX,TAF1,HIST1H2BD,ERCC2
REGULATION OF INTRACELLULAR PROTEIN TRANSPORT%GOBP%GO:0033157	regulation of intracellular protein transport	0.0024080152501058105	0.0024080152501058105	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1,LRRK2,SETD2
HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20190610%WP4206%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4206_r97123	0.0024168790647274264	0.0024168790647274264	+1	TP53,KEAP1,NFE2L2
CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.3	Cyclin E associated events during G1 S transition	0.0024168790647274264	0.0024168790647274264	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
ACTIVIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0032924	activin receptor signaling pathway	0.0024168790647274264	0.0024168790647274264	+1	ACVR1B,ACVR2A,SMAD2
DIGESTIVE TRACT MORPHOGENESIS%GOBP%GO:0048546	digestive tract morphogenesis	0.0024168790647274264	0.0024168790647274264	+1	PDGFRA,FGFR2,SOX17
MAMMARY GLAND EPITHELIUM DEVELOPMENT%GOBP%GO:0061180	mammary gland epithelium development	0.0024168790647274264	0.0024168790647274264	+1	AKT1,ERBB4,FGFR2
CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 69%389513	CTLA4 inhibitory signaling	0.0024168790647274264	0.0024168790647274264	+1	AKT1,PPP2R1A,PTPN11
FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 69%5654700	FRS-mediated FGFR2 signaling	0.0024168790647274264	0.0024168790647274264	+1	KRAS,NRAS,PTPN11
REGULATION OF MITOTIC SPINDLE ASSEMBLY%GOBP%GO:1901673	regulation of mitotic spindle assembly	0.0024168790647274264	0.0024168790647274264	+1	STAG2,SMC1A,SMC3
REGULATION OF ACTIVIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0032925	regulation of activin receptor signaling pathway	0.0024168790647274264	0.0024168790647274264	+1	ACVR1B,ACVR2A,SMAD2
REGULATION OF CELLULAR RESPONSE TO DRUG%GOBP%GO:2001038	regulation of cellular response to drug	0.0024168790647274264	0.0024168790647274264	+1	NFE2L2,HGF,LRRK2
ATRIOVENTRICULAR VALVE MORPHOGENESIS%GOBP%GO:0003181	atrioventricular valve morphogenesis	0.0024168790647274264	0.0024168790647274264	+1	NOTCH1,SMAD4,TGFBR2
BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE%GOBP%GO:0048754	branching morphogenesis of an epithelial tube	0.002418136922074949	0.002418136922074949	+1	CTNNB1,WT1,FGFR2,TGFBR2
REGULATION OF GLUCOSE TRANSMEMBRANE TRANSPORT%GOBP%GO:0010827	regulation of glucose transmembrane transport	0.002418136922074949	0.002418136922074949	+1	PIK3R1,AKT1,BRAF,PTPN11
NEGATIVE REGULATION OF COLD-INDUCED THERMOGENESIS%GOBP%GO:0120163	negative regulation of cold-induced thermogenesis	0.002418136922074949	0.002418136922074949	+1	RB1,NOTCH1,STK11,TLR4
PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY	PID_LKB1_PATHWAY	0.002418136922074949	0.002418136922074949	+1	TP53,STK11,MTOR,SMAD4
PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY	PID_FANCONI_PATHWAY	0.002418136922074949	0.002418136922074949	+1	ATM,BRCA1,BRCA2,ATR
CELLULAR RESPONSE TO MECHANICAL STIMULUS%GOBP%GO:0071260	cellular response to mechanical stimulus	0.002418136922074949	0.002418136922074949	+1	MAP3K1,MAP2K4,SOX9,TLR4
THYMIC STROMAL LYMPHOPOIETIN (TSLP) SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP2203%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2203_r96065	0.002418136922074949	0.002418136922074949	+1	PIK3CA,AKT1,MTOR,PTPN11
CELLULAR RESPONSE TO IONIZING RADIATION%GOBP%GO:0071479	cellular response to ionizing radiation	0.002418136922074949	0.002418136922074949	+1	TP53,ATM,CDKN1A,ATR
LYMPHOCYTE COSTIMULATION%GOBP%GO:0031294	lymphocyte costimulation	0.002418136922074949	0.002418136922074949	+1	PIK3CA,PIK3R1,AKT1,PTPN11
FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY	Fanconi anemia pathway	0.002418136922074949	0.002418136922074949	+1	ATM,BRCA1,BRCA2,ATR
MACROMOLECULE METHYLATION%GOBP%GO:0043414	macromolecule methylation	0.002432914129608613	0.002432914129608613	+1	DNMT3A,KDM6A,TET2,ATRX,SETD2,NSD1,EZH2
REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS%GOBP%GO:2000377	regulation of reactive oxygen species metabolic process	0.002464146072804706	0.002464146072804706	+1	TP53,AKT1,TLR4,BRCA1,TGFBR2,CDKN1A
POSITIVE REGULATION OF HEMOPOIESIS%GOBP%GO:1903708	positive regulation of hemopoiesis	0.002464146072804706	0.002464146072804706	+1	GATA3,RUNX1,TGFBR2,CBFB,ACVR1B,ACVR2A
CELLULAR RESPONSE TO METAL ION%GOBP%GO:0071248	cellular response to metal ion	0.002464146072804706	0.002464146072804706	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
RANKL%NETPATH%RANKL	RANKL	0.0024873892005849397	0.0024873892005849397	+1	EGFR,PIK3R1,RUNX1,AKT1,MTOR
REGULATION OF LEUKOCYTE DIFFERENTIATION%GOBP%GO:1902105	regulation of leukocyte differentiation	0.002502646644681582	0.002502646644681582	+1	GATA3,FBXW7,RUNX1,MTOR,TLR4,TGFBR2,CBFB
POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION%GOBP%GO:0050679	positive regulation of epithelial cell proliferation	0.002560059362848535	0.002560059362848535	+1	EGFR,NRAS,AKT1,SOX9,FGFR2,EGR3
FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING	FoxO family signaling	0.002581366105942693	0.002581366105942693	+1	CTNNB1,AKT1,CDKN1B,EP300
RETT SYNDROME CAUSING GENES%WIKIPATHWAYS_20190610%WP4312%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4312_r104287	0.002581366105942693	0.002581366105942693	+1	BRAF,SMC1A,TBL1XR1,NCOR1
ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20190610%WP2873%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2873_r95229	0.002581366105942693	0.002581366105942693	+1	EGFR,NFE2L2,CDKN1B,EP300
POSITIVE REGULATION OF NEURON DEATH%GOBP%GO:1901216	positive regulation of neuron death	0.002581366105942693	0.002581366105942693	+1	NF1,FBXW7,CTNNB1,TLR4
PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY	PID_HEDGEHOG_GLI_PATHWAY	0.002581366105942693	0.002581366105942693	+1	AKT1,FOXA2,SIN3A,SPOP
PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY	PID_CERAMIDE_PATHWAY	0.002581366105942693	0.002581366105942693	+1	RB1,MAP3K1,MAP2K4,AKT1
HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS	Hedgehog signaling events mediated by Gli proteins	0.002581366105942693	0.002581366105942693	+1	AKT1,FOXA2,SIN3A,SPOP
POSITIVE REGULATION OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE%GOBP%GO:1903078	positive regulation of protein localization to plasma membrane	0.002581366105942693	0.002581366105942693	+1	EGFR,PIK3R1,EPHA3,AKT1
CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 69%69656	Cyclin A:Cdk2-associated events at S phase entry	0.0025966063380593314	0.0025966063380593314	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A
EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING%GOBP%GO:0009792	embryo development ending in birth or egg hatching	0.002643854714800844	0.002643854714800844	+1	GATA3,CTNNB1,SOX9,BRCA1,PDGFRA,FGFR2,TGFBR2
POSITIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS%GOBP%GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus	0.002694552824931387	0.002694552824931387	+1	STK11,EP300,SMAD4
PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY	PDGFR-alpha signaling pathway	0.002694552824931387	0.002694552824931387	+1	PIK3CA,PIK3R1,PDGFRA
POSITIVE REGULATION OF GENE SILENCING BY MIRNA%GOBP%GO:2000637	positive regulation of gene silencing by miRNA	0.002694552824931387	0.002694552824931387	+1	TP53,EGFR,AJUBA
POSITIVE REGULATION OF MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:1905332	positive regulation of morphogenesis of an epithelium	0.002694552824931387	0.002694552824931387	+1	GATA3,SOX9,MTOR
CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 69%5621575	CD209 (DC-SIGN) signaling	0.002694552824931387	0.002694552824931387	+1	KRAS,NRAS,EP300
NEOVASCULARISATION PROCESSES%WIKIPATHWAYS_20190610%WP4331%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4331_r102451	0.002694552824931387	0.002694552824931387	+1	AKT1,KIT,SMAD2
POSITIVE REGULATION OF BMP SIGNALING PATHWAY%GOBP%GO:0030513	positive regulation of BMP signaling pathway	0.002694552824931387	0.002694552824931387	+1	NOTCH1,SMAD4,SMAD2
EMBRYONIC AXIS SPECIFICATION%GOBP%GO:0000578	embryonic axis specification	0.002694552824931387	0.002694552824931387	+1	TBX3,WT1,SMAD2
IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20190610%WP3640%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3640_r89384	0.002694552824931387	0.002694552824931387	+1	CDKN1B,KIT,PDGFRA
P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397	p53 pathway by glucose deprivation	0.002694552824931387	0.002694552824931387	+1	TP53,STK11,AKT1
POSITIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY%GOBP%GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	0.002694552824931387	0.002694552824931387	+1	STK11,EP300,SMAD4
PROTEIN METHYLATION%GOBP%GO:0006479	protein methylation	0.0026979372481647323	0.0026979372481647323	+1	KDM6A,TET2,SETD2,NSD1,EZH2
PROTEIN ALKYLATION%GOBP%GO:0008213	protein alkylation	0.0026979372481647323	0.0026979372481647323	+1	KDM6A,TET2,SETD2,NSD1,EZH2
REGULATION OF LIPASE ACTIVITY%GOBP%GO:0060191	regulation of lipase activity	0.0026979372481647323	0.0026979372481647323	+1	EGFR,KIT,PDGFRA,FGFR2,FGFR3
EBOLA VIRUS PATHWAY ON HOST%WIKIPATHWAYS_20190610%WP4217%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4217_r101851	0.0027039522068464045	0.0027039522068464045	+1	PIK3CA,EGFR,PIK3R1,AKT1,TLR4,EP300
G1 S TRANSITION%REACTOME%R-HSA-69206.2	G1 S Transition	0.0027039522068464045	0.0027039522068464045	+1	RB1,AKT1,CDKN1B,CCND1,CDKN1A,PPP2R1A
PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY	PID_FOXO_PATHWAY	0.00273718788301017	0.00273718788301017	+1	CTNNB1,AKT1,CDKN1B,EP300
REGULATION OF MICROTUBULE CYTOSKELETON%WIKIPATHWAYS_20190610%WP2038%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2038_r94910	0.00273718788301017	0.00273718788301017	+1	PIK3CA,PTEN,APC,AKT1
FOREBRAIN DEVELOPMENT%GOBP%GO:0030900	forebrain development	0.00280635467309814	0.00280635467309814	+1	PTEN,NF1,ERBB4,LRRK2,FGFR2,SIN3A
ACTIVATION OF RAS IN B CELLS%REACTOME%R-HSA-1169092.1	Activation of RAS in B cells	0.0028122716539087816	0.0028122716539087816	+1	KRAS,NRAS
PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS	PLK3 signaling events	0.0028122716539087816	0.0028122716539087816	+1	TP53,CHEK2
ENDOCARDIUM MORPHOGENESIS%GOBP%GO:0003160	endocardium morphogenesis	0.0028122716539087816	0.0028122716539087816	+1	NOTCH1,SOX17
RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME%R-HSA-8935964.1	RUNX1 regulates expression of components of tight junctions	0.0028122716539087816	0.0028122716539087816	+1	RUNX1,CBFB
LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 69%3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.0028122716539087816	0.0028122716539087816	+1	CTNNB1,EP300
NEGATIVE REGULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL%GOBP%GO:0090394	negative regulation of excitatory postsynaptic potential	0.0028122716539087816	0.0028122716539087816	+1	PTEN,LRRK2
TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 69%3656532	TGFBR1 KD Mutants in Cancer	0.0028122716539087816	0.0028122716539087816	+1	TGFBR2,SMAD2
POSITIVE REGULATION OF HISTONE H3-K9 ACETYLATION%GOBP%GO:2000617	positive regulation of histone H3-K9 acetylation	0.0028122716539087816	0.0028122716539087816	+1	BRCA1,SMAD4
MEMBRANOUS SEPTUM MORPHOGENESIS%GOBP%GO:0003149	membranous septum morphogenesis	0.0028122716539087816	0.0028122716539087816	+1	FGFR2,TGFBR2
REGULATION OF PROTEIN AUTOUBIQUITINATION%GOBP%GO:1902498	regulation of protein autoubiquitination	0.0028122716539087816	0.0028122716539087816	+1	LRRK2,TAF1
POSITIVE REGULATION OF OXIDATIVE STRESS-INDUCED NEURON DEATH%GOBP%GO:1903223	positive regulation of oxidative stress-induced neuron death	0.0028122716539087816	0.0028122716539087816	+1	FBXW7,TLR4
POSITIVE REGULATION OF MALE GONAD DEVELOPMENT%GOBP%GO:2000020	positive regulation of male gonad development	0.0028122716539087816	0.0028122716539087816	+1	SOX9,WT1
DETERMINATION OF ADULT LIFESPAN%GOBP%GO:0008340	determination of adult lifespan	0.0028122716539087816	0.0028122716539087816	+1	TP53,LRRK2
POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA%GOBP%GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.0028122716539087816	0.0028122716539087816	+1	NOTCH1,NFE2L2
SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%R-HSA-3304356.2	SMAD2 3 Phosphorylation Motif Mutants in Cancer	0.0028122716539087816	0.0028122716539087816	+1	TGFBR2,SMAD2
NEGATIVE REGULATION OF CELL PROLIFERATION INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:1901723	negative regulation of cell proliferation involved in kidney development	0.0028122716539087816	0.0028122716539087816	+1	GATA3,WT1
ISOCITRATE METABOLIC PROCESS%GOBP%GO:0006102	isocitrate metabolic process	0.0028122716539087816	0.0028122716539087816	+1	IDH1,IDH2
POSITIVE REGULATION OF LYMPHOCYTE ACTIVATION%GOBP%GO:0051251	positive regulation of lymphocyte activation	0.0028272145149850045	0.0028272145149850045	+1	PIK3CA,PIK3R1,GATA3,RUNX1,AKT1,TGFBR2,CBFB,PTPN11
POSITIVE REGULATION OF BINDING%GOBP%GO:0051099	positive regulation of binding	0.002865175144526199	0.002865175144526199	+1	GATA3,RB1,CTNNB1,LRRK2,EP300,TAF1
PEPTIDYL-LYSINE METHYLATION%GOBP%GO:0018022	peptidyl-lysine methylation	0.002895581700859707	0.002895581700859707	+1	KDM6A,TET2,SETD2,EZH2
REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY%GOBP%GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.0029200853988611115	0.0029200853988611115	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
CCR7%IOB%CCR7	CCR7	0.002986073277535106	0.002986073277535106	+1	MAP2K4,AKT1,MTOR
SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY	Signaling events mediated by the Hedgehog family	0.002986073277535106	0.002986073277535106	+1	PIK3CA,PIK3R1,AKT1
POSITIVE REGULATION OF POSTTRANSCRIPTIONAL GENE SILENCING%GOBP%GO:0060148	positive regulation of posttranscriptional gene silencing	0.002986073277535106	0.002986073277535106	+1	TP53,EGFR,AJUBA
ATRIOVENTRICULAR VALVE DEVELOPMENT%GOBP%GO:0003171	atrioventricular valve development	0.002986073277535106	0.002986073277535106	+1	NOTCH1,SMAD4,TGFBR2
PI3K/AKT/MTOR - VITD3 SIGNALLING%WIKIPATHWAYS_20190610%WP4141%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4141_r98518	0.002986073277535106	0.002986073277535106	+1	PIK3CA,AKT1,MTOR
BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY	BIOCARTA_CHEMICAL_PATHWAY	0.002986073277535106	0.002986073277535106	+1	TP53,AKT1,ATM
PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY	PID_HEDGEHOG_2PATHWAY	0.002986073277535106	0.002986073277535106	+1	PIK3CA,PIK3R1,AKT1
GLAND MORPHOGENESIS%GOBP%GO:0022612	gland morphogenesis	0.002986073277535106	0.002986073277535106	+1	SOX9,ELF3,FGFR2
PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY	PID_PDGFRA_PATHWAY	0.002986073277535106	0.002986073277535106	+1	PIK3CA,PIK3R1,PDGFRA
REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS%GOBP%GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	0.0030415696814583963	0.0030415696814583963	+1	STK11,EP300,SMAD4,TGFBR2,SMAD2
NCRNAS INVOLVED IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20190610%WP4336%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4336_r103459	0.0030415696814583963	0.0030415696814583963	+1	APC,CTNNB1,CCND1,SOX17,EZH2
APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 69%75153	Apoptotic execution phase	0.003080306138388839	0.003080306138388839	+1	APC,CTNNB1,CDH1,HIST1H1C
TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING	TGF-beta receptor signaling	0.003080306138388839	0.003080306138388839	+1	CTNNB1,SMAD4,TGFBR2,SMAD2
REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS%GOBP%GO:2001020	regulation of response to DNA damage stimulus	0.003136806887377466	0.003136806887377466	+1	EGFR,ATM,BRCA1,POLQ,SETD2,ATR,AXIN2
FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.1	Fc epsilon receptor (FCERI) signaling	0.0031625466888866986	0.0031625466888866986	+1	PIK3CA,KRAS,PIK3R1,MAP3K1,NRAS,MAP2K4
CELLULAR RESPONSE TO HYPOXIA%GOBP%GO:0071456	cellular response to hypoxia	0.0031625466888866986	0.0031625466888866986	+1	TP53,VHL,NOTCH1,NFE2L2,MTOR,EP300
PTEN REGULATION%REACTOME DATABASE ID RELEASE 69%6807070	PTEN Regulation	0.0031625466888866986	0.0031625466888866986	+1	TP53,PTEN,AKT1,MTOR,MECOM,EZH2
CELLULAR RESPONSE TO STEROID HORMONE STIMULUS%GOBP%GO:0071383	cellular response to steroid hormone stimulus	0.003178768999261702	0.003178768999261702	+1	ARID1A,RB1,CTNNB1,AR,BRCA1
PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY	PID_PTP1B_PATHWAY	0.0032912189804064854	0.0032912189804064854	+1	PIK3CA,EGFR,PIK3R1,AKT1
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 69%1660499	Synthesis of PIPs at the plasma membrane	0.0032912189804064854	0.0032912189804064854	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B	Signaling events mediated by PTP1B	0.0032912189804064854	0.0032912189804064854	+1	PIK3CA,EGFR,PIK3R1,AKT1
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.1	RUNX2 regulates osteoblast differentiation	0.003348492880818135	0.003348492880818135	+1	RB1,AR,CBFB
POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0055025	positive regulation of cardiac muscle tissue development	0.003348492880818135	0.003348492880818135	+1	NOTCH1,ERBB4,FGFR2
NRF2-ARE REGULATION%WIKIPATHWAYS_20190610%WP4357%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4357_r98705	0.003348492880818135	0.003348492880818135	+1	PIK3CA,KEAP1,NFE2L2
BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY	BIOCARTA_IGF1R_PATHWAY	0.003348492880818135	0.003348492880818135	+1	PIK3CA,PIK3R1,AKT1
ESTROGEN SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP712%HOMO SAPIENS	http://www.wikipathways.org/instance/WP712_r78491	0.003348492880818135	0.003348492880818135	+1	PIK3CA,AKT1,BRAF
NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 69%5654732	Negative regulation of FGFR3 signaling	0.003348492880818135	0.003348492880818135	+1	BRAF,PPP2R1A,PTPN11
POSITIVE REGULATION OF DNA-TEMPLATED TRANSCRIPTION, INITIATION%GOBP%GO:2000144	positive regulation of DNA-templated transcription, initiation	0.003348492880818135	0.003348492880818135	+1	TP53,CTNNB1,TAF1
REGULATION OF CARDIAC MUSCLE TISSUE GROWTH%GOBP%GO:0055021	regulation of cardiac muscle tissue growth	0.003348492880818135	0.003348492880818135	+1	NOTCH1,ERBB4,FGFR2
HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.2	Homology Directed Repair	0.003371611525730653	0.003371611525730653	+1	ATM,BRCA1,POLQ,BRCA2,ATR,HIST1H2BD
CARDIAC CHAMBER DEVELOPMENT%GOBP%GO:0003205	cardiac chamber development	0.003469178440501652	0.003469178440501652	+1	GATA3,NOTCH1,FGFR2,SMAD4,TGFBR2
NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH%GOBP%GO:0048640	negative regulation of developmental growth	0.003480972282787126	0.003480972282787126	+1	PTEN,CDKN1B,FGFR3,CDKN1A
PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY	PID_AR_TF_PATHWAY	0.003480972282787126	0.003480972282787126	+1	MAP2K4,CEBPA,AR,EP300
BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY	BIOCARTA_NFAT_PATHWAY	0.003480972282787126	0.003480972282787126	+1	PIK3CA,PIK3R1,AKT1,PIK3CG
REGULATION OF EPITHELIAL CELL MIGRATION%GOBP%GO:0010632	regulation of epithelial cell migration	0.003480972282787126	0.003480972282787126	+1	PTEN,NF1,GATA3,NOTCH1,AKT1,SOX9,MTOR
ENDOCRINE SYSTEM DEVELOPMENT%GOBP%GO:0035270	endocrine system development	0.003480972282787126	0.003480972282787126	+1	NF1,AKT1,WT1,FOXA2
REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY	Regulation of Androgen receptor activity	0.003480972282787126	0.003480972282787126	+1	MAP2K4,CEBPA,AR,EP300
CELLULAR RESPONSE TO DECREASED OXYGEN LEVELS%GOBP%GO:0036294	cellular response to decreased oxygen levels	0.003480972282787126	0.003480972282787126	+1	TP53,VHL,NOTCH1,NFE2L2,MTOR,EP300
METHYLATION%GOBP%GO:0032259	methylation	0.0036846908110877846	0.0036846908110877846	+1	DNMT3A,KDM6A,TET2,ATRX,SETD2,NSD1,EZH2
DOPAMINERGIC NEURON DIFFERENTIATION%GOBP%GO:0071542	dopaminergic neuron differentiation	0.0037188675221016543	0.0037188675221016543	+1	CTNNB1,FOXA1,FOXA2
POSITIVE REGULATION OF T CELL DIFFERENTIATION%GOBP%GO:0045582	positive regulation of T cell differentiation	0.0037188675221016543	0.0037188675221016543	+1	GATA3,RUNX1,TGFBR2,CBFB
BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY	BIOCARTA_TPO_PATHWAY	0.0037188675221016543	0.0037188675221016543	+1	PIK3CA,PIK3R1,PIK3CG
IL9%NETPATH%IL9	IL9	0.0037188675221016543	0.0037188675221016543	+1	PIK3R1,AKT1,PTPN11
POSITIVE REGULATION OF GLUCOSE IMPORT%GOBP%GO:0046326	positive regulation of glucose import	0.0037188675221016543	0.0037188675221016543	+1	PIK3R1,AKT1,PTPN11
BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY	BIOCARTA_ECM_PATHWAY	0.0037188675221016543	0.0037188675221016543	+1	PIK3CA,PIK3R1,PIK3CG
BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY	BIOCARTA_NTHI_PATHWAY	0.0037188675221016543	0.0037188675221016543	+1	EP300,SMAD4,TGFBR2
RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY	RAC1 signaling pathway	0.0037188675221016543	0.0037188675221016543	+1	CTNNB1,MAP3K1,CDH1,MAP2K4
POSITIVE REGULATION OF PROTEIN LOCALIZATION TO CELL PERIPHERY%GOBP%GO:1904377	positive regulation of protein localization to cell periphery	0.0037188675221016543	0.0037188675221016543	+1	EGFR,PIK3R1,EPHA3,AKT1
PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY	PID_RAC1_PATHWAY	0.0037188675221016543	0.0037188675221016543	+1	CTNNB1,MAP3K1,CDH1,MAP2K4
POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS%GOBP%GO:0043525	positive regulation of neuron apoptotic process	0.0037188675221016543	0.0037188675221016543	+1	NF1,FBXW7,CTNNB1
OUTFLOW TRACT SEPTUM MORPHOGENESIS%GOBP%GO:0003148	outflow tract septum morphogenesis	0.0037188675221016543	0.0037188675221016543	+1	FGFR2,SMAD4,TGFBR2
REGULATION OF OXIDATIVE STRESS-INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.0037188675221016543	0.0037188675221016543	+1	FBXW7,NFE2L2,AKT1
RESPONSE TO GAMMA RADIATION%GOBP%GO:0010332	response to gamma radiation	0.0037188675221016543	0.0037188675221016543	+1	TP53,ATM,ATR
TNF ALPHA SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP231%HOMO SAPIENS	http://www.wikipathways.org/instance/WP231_r89895	0.003741712644559458	0.003741712644559458	+1	KRAS,MAP3K1,NRAS,MAP2K4,AKT1
ATRIOVENTRICULAR CANAL DEVELOPMENT%GOBP%GO:0036302	atrioventricular canal development	0.00385949670082296	0.00385949670082296	+1	SMAD4,PTPN11
ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME%R-HSA-9028335.1	Activated NTRK2 signals through PI3K	0.00385949670082296	0.00385949670082296	+1	PIK3CA,PIK3R1
ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-HSA-9603381.1	Activated NTRK3 signals through PI3K	0.00385949670082296	0.00385949670082296	+1	PIK3CA,PIK3R1
PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY	PID_TGFBR_PATHWAY	0.00385949670082296	0.00385949670082296	+1	CTNNB1,SMAD4,TGFBR2,SMAD2
LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.1	Loss of Function of TGFBR1 in Cancer	0.00385949670082296	0.00385949670082296	+1	TGFBR2,SMAD2
ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME%R-HSA-9034864.1	Activated NTRK3 signals through RAS	0.00385949670082296	0.00385949670082296	+1	KRAS,NRAS
TRAIL%IOB%TRAIL	TRAIL	0.00385949670082296	0.00385949670082296	+1	CTNNB1,AKT1,ATM,CHEK2
INTERFERON TYPE I SIGNALING PATHWAYS%WIKIPATHWAYS_20190610%WP585%HOMO SAPIENS	http://www.wikipathways.org/instance/WP585_r103737	0.00385949670082296	0.00385949670082296	+1	PIK3R1,MAP3K1,MTOR,PTPN11
STAT5 ACTIVATION%REACTOME DATABASE ID RELEASE 69%9645135	STAT5 Activation	0.00385949670082296	0.00385949670082296	+1	FLT3,PTPN11
SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 69%112412	SOS-mediated signalling	0.00385949670082296	0.00385949670082296	+1	KRAS,NRAS
SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.1	Signaling by RAS mutants	0.00385949670082296	0.00385949670082296	+1	KRAS,NF1,NRAS,BRAF
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8939246.1	RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	0.00385949670082296	0.00385949670082296	+1	RUNX1,CBFB
REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation	0.00385949670082296	0.00385949670082296	+1	RUNX1,CBFB
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 69%8939245	RUNX1 regulates transcription of genes involved in BCR signaling	0.00385949670082296	0.00385949670082296	+1	RUNX1,CBFB
PTK6 REGULATES CELL CYCLE%REACTOME%R-HSA-8849470.1	PTK6 Regulates Cell Cycle	0.00385949670082296	0.00385949670082296	+1	CDKN1B,CCND1
OTIC VESICLE DEVELOPMENT%GOBP%GO:0071599	otic vesicle development	0.00385949670082296	0.00385949670082296	+1	SOX9,FGFR2
CXCR4%IOB%CXCR4	CXCR4	0.00385949670082296	0.00385949670082296	+1	EGFR,PIK3R1,CTNNB1,AKT1,PTPN11
REGULATION OF TOLL-LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP1449%HOMO SAPIENS	http://www.wikipathways.org/instance/WP1449_r103013	0.00385949670082296	0.00385949670082296	+1	PIK3CA,PIK3R1,MAP2K4,AKT1,PIK3CG,TLR4
REGULATION OF MALE GONAD DEVELOPMENT%GOBP%GO:2000018	regulation of male gonad development	0.00385949670082296	0.00385949670082296	+1	SOX9,WT1
RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 69%8931987	RUNX1 regulates estrogen receptor mediated transcription	0.00385949670082296	0.00385949670082296	+1	RUNX1,CBFB
REGULATION OF WOUND HEALING, SPREADING OF EPIDERMAL CELLS%GOBP%GO:1903689	regulation of wound healing, spreading of epidermal cells	0.00385949670082296	0.00385949670082296	+1	PTEN,MTOR
REGULATION OF PROTEIN LOCALIZATION TO CHROMATIN%GOBP%GO:1905634	regulation of protein localization to chromatin	0.00385949670082296	0.00385949670082296	+1	RB1,SETD2
POSITIVE REGULATION OF GONAD DEVELOPMENT%GOBP%GO:1905941	positive regulation of gonad development	0.00385949670082296	0.00385949670082296	+1	SOX9,WT1
LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME%R-HSA-9022537.1	Loss of MECP2 binding ability to the NCoR SMRT complex	0.00385949670082296	0.00385949670082296	+1	TBL1XR1,NCOR1
PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 69%8857538	PTK6 promotes HIF1A stabilization	0.00385949670082296	0.00385949670082296	+1	EGFR,LRRK2
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 69%8939256	RUNX1 regulates transcription of genes involved in WNT signaling	0.00385949670082296	0.00385949670082296	+1	RUNX1,CBFB
ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 69%9634635	Estrogen-stimulated signaling through PRKCZ	0.00385949670082296	0.00385949670082296	+1	KRAS,NRAS
REGULATION OF MESENCHYMAL STEM CELL DIFFERENTIATION%GOBP%GO:2000739	regulation of mesenchymal stem cell differentiation	0.00385949670082296	0.00385949670082296	+1	SOX9,PDGFRA
RESPONSE TO MECHANICAL STIMULUS%GOBP%GO:0009612	response to mechanical stimulus	0.00385949670082296	0.00385949670082296	+1	MAP3K1,MAP2K4,SOX9,TLR4,KIT
POSITIVE REGULATION OF CD8-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	0.00385949670082296	0.00385949670082296	+1	RUNX1,CBFB
REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS%GOBP%GO:0090287	regulation of cellular response to growth factor stimulus	0.0039776454081566735	0.0039776454081566735	+1	GATA3,NOTCH1,STK11,EP300,SMAD4,TGFBR2,SMAD2
REGULATION OF PROTEIN LOCALIZATION TO CELL PERIPHERY%GOBP%GO:1904375	regulation of protein localization to cell periphery	0.003994809341691828	0.003994809341691828	+1	EGFR,PIK3R1,EPHA3,AKT1,AR
NEGATIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0010719	negative regulation of epithelial to mesenchymal transition	0.0040453059138282725	0.0040453059138282725	+1	PTEN,FOXA1,FOXA2
NEGATIVE REGULATION OF MITOTIC SISTER CHROMATID SEGREGATION%GOBP%GO:0033048	negative regulation of mitotic sister chromatid segregation	0.0040453059138282725	0.0040453059138282725	+1	APC,ATM,ATRX
PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY	PID_HDAC_CLASSIII_PATHWAY	0.0040453059138282725	0.0040453059138282725	+1	TP53,EP300,CDKN1A
HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20190610%WP3668%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3668_r97639	0.0040453059138282725	0.0040453059138282725	+1	SMAD4,TGFBR2,SMAD2
CRANIAL SKELETAL SYSTEM DEVELOPMENT%GOBP%GO:1904888	cranial skeletal system development	0.0040453059138282725	0.0040453059138282725	+1	PDGFRA,FGFR2,TGFBR2
AUTONOMIC NERVOUS SYSTEM DEVELOPMENT%GOBP%GO:0048483	autonomic nervous system development	0.0040453059138282725	0.0040453059138282725	+1	NF1,GATA3,CTNNB1
TOR SIGNALING%GOBP%GO:0031929	TOR signaling	0.0040453059138282725	0.0040453059138282725	+1	GATA3,AKT1,MTOR
REGULATION OF RESPONSE TO REACTIVE OXYGEN SPECIES%GOBP%GO:1901031	regulation of response to reactive oxygen species	0.0040453059138282725	0.0040453059138282725	+1	NFE2L2,HGF,LRRK2
EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0001837	epithelial to mesenchymal transition	0.004066299904194712	0.004066299904194712	+1	NOTCH1,CTNNB1,SOX9,HGF
REGULATION OF GENE SILENCING%GOBP%GO:0060968	regulation of gene silencing	0.0040997105046090485	0.0040997105046090485	+1	TP53,EGFR,AJUBA,HIST1H1C,SIN3A,NCOR1
MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0060537	muscle tissue development	0.0040997105046090485	0.0040997105046090485	+1	NF1,NOTCH1,WT1,PDGFRA,FGFR2,SMAD4
CARDIAC MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0048738	cardiac muscle tissue development	0.0041367377012743985	0.0041367377012743985	+1	NOTCH1,WT1,PDGFRA,FGFR2,SMAD4
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 69%8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	0.0041367377012743985	0.0041367377012743985	+1	RUNX1,EP300,CBFB,SIN3A,HIST1H2BD
CIRCADIAN RHYTHM%GOBP%GO:0007623	circadian rhythm	0.0042896125254449574	0.0042896125254449574	+1	TP53,PTEN,EP300,EGR3,NCOR1
SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2894858.1	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.0042896125254449574	0.0042896125254449574	+1	NOTCH1,EP300,TBL1XR1,NCOR1
B CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP23%HOMO SAPIENS	http://www.wikipathways.org/instance/WP23_r92558	0.0042896125254449574	0.0042896125254449574	+1	PIK3R1,AKT1,BRAF,PIK3CG,PTPN11
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 69%2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.0042896125254449574	0.0042896125254449574	+1	NOTCH1,EP300,TBL1XR1,NCOR1
SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.2	Signaling by NOTCH1 in Cancer	0.0042896125254449574	0.0042896125254449574	+1	NOTCH1,EP300,TBL1XR1,NCOR1
POSITIVE REGULATION OF MITOTIC CELL CYCLE PHASE TRANSITION%GOBP%GO:1901992	positive regulation of mitotic cell cycle phase transition	0.0042896125254449574	0.0042896125254449574	+1	EGFR,RB1,AKT1,CCND1
NEGATIVE REGULATION OF CYTOSKELETON ORGANIZATION%GOBP%GO:0051494	negative regulation of cytoskeleton organization	0.0042896125254449574	0.0042896125254449574	+1	APC,NAV3,NPM1,BRCA1,SMAD4
CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%R-HSA-2644606.1	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.0042896125254449574	0.0042896125254449574	+1	NOTCH1,EP300,TBL1XR1,NCOR1
CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.1	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.0042896125254449574	0.0042896125254449574	+1	NOTCH1,EP300,TBL1XR1,NCOR1
REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 69%8943724	Regulation of PTEN gene transcription	0.0042896125254449574	0.0042896125254449574	+1	TP53,MTOR,MECOM,EZH2
STABILIZATION OF P53%REACTOME%R-HSA-69541.4	Stabilization of p53	0.0042896125254449574	0.0042896125254449574	+1	TP53,CDKN2A,ATM,CHEK2
RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.1	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.004434114123022623	0.004434114123022623	+1	ATM,BRCA1,BRCA2
REGULATION OF SPINDLE ASSEMBLY%GOBP%GO:0090169	regulation of spindle assembly	0.004434114123022623	0.004434114123022623	+1	STAG2,SMC1A,SMC3
IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS	IL3-mediated signaling events	0.004434114123022623	0.004434114123022623	+1	PIK3CA,PIK3R1,PTPN11
PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY	PID_ALK1_PATHWAY	0.004434114123022623	0.004434114123022623	+1	SMAD4,TGFBR2,ACVR2A
EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING	Ephrin B reverse signaling	0.004434114123022623	0.004434114123022623	+1	PIK3CA,PIK3R1,MAP2K4
NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 69%5654726	Negative regulation of FGFR1 signaling	0.004434114123022623	0.004434114123022623	+1	BRAF,PPP2R1A,PTPN11
ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS	ALK1 signaling events	0.004434114123022623	0.004434114123022623	+1	SMAD4,TGFBR2,ACVR2A
CELLULAR RESPONSE TO INTERLEUKIN-6%GOBP%GO:0071354	cellular response to interleukin-6	0.004434114123022623	0.004434114123022623	+1	CEBPA,SMAD4,PTPN11
POSITIVE REGULATION OF G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	0.004434114123022623	0.004434114123022623	+1	EGFR,AKT1,CCND1
VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.2	VEGFR2 mediated vascular permeability	0.004434114123022623	0.004434114123022623	+1	CTNNB1,AKT1,MTOR
3-PHOSPHOINOSITIDE BIOSYNTHESIS%HUMANCYC%PWY-6352	3-phosphoinositide biosynthesis	0.004434114123022623	0.004434114123022623	+1	PIK3CA,PIK3R1,PIK3CG
EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20190610%WP4300%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4300_r97801	0.004434114123022623	0.004434114123022623	+1	PTEN,EGFR,TLR4
TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-HSA-8986944.2	Transcriptional Regulation by MECP2	0.004506116851465489	0.004506116851465489	+1	PTEN,SIN3A,TBL1XR1,NCOR1
DIGESTIVE TRACT DEVELOPMENT%GOBP%GO:0048565	digestive tract development	0.004506116851465489	0.004506116851465489	+1	KIT,PDGFRA,FGFR2,SOX17
NEGATIVE REGULATION OF WOUND HEALING%GOBP%GO:0061045	negative regulation of wound healing	0.004506116851465489	0.004506116851465489	+1	PTEN,CDKN1B,PDGFRA,CDKN1A
POSITIVE REGULATION OF GENE EXPRESSION, EPIGENETIC%GOBP%GO:0045815	positive regulation of gene expression, epigenetic	0.004506116851465489	0.004506116851465489	+1	ARID1A,HIST1H1C,EP300,SF3B1
KIDNEY EPITHELIUM DEVELOPMENT%GOBP%GO:0072073	kidney epithelium development	0.004506116851465489	0.004506116851465489	+1	GATA3,SOX9,WT1,FGFR2
POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN%GOBP%GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	0.004506116851465489	0.004506116851465489	+1	FLT3,ERBB4,KIT,FGFR3
REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS%GOBP%GO:0061136	regulation of proteasomal protein catabolic process	0.004587236183258195	0.004587236183258195	+1	FBXW7,KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
BONE DEVELOPMENT%GOBP%GO:0060348	bone development	0.004610468353741536	0.004610468353741536	+1	TP53,SOX9,KIT,FGFR2,FGFR3
REGULATION OF PROTEASOMAL UBIQUITIN-DEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	0.004610468353741536	0.004610468353741536	+1	KEAP1,NFE2L2,CEBPA,LRRK2,TAF1
CELLULAR RESPONSE TO OXYGEN LEVELS%GOBP%GO:0071453	cellular response to oxygen levels	0.004735914663353079	0.004735914663353079	+1	TP53,VHL,NOTCH1,NFE2L2,MTOR,EP300
RESPONSE TO RETINOIC ACID%GOBP%GO:0032526	response to retinoic acid	0.004779718791268278	0.004779718791268278	+1	EPHA3,SOX9,ATM,ASXL1
TUBE FORMATION%GOBP%GO:0035148	tube formation	0.004779718791268278	0.004779718791268278	+1	GATA3,NOTCH1,SOX9,FGFR2
CIRCADIAN RHYTHM RELATED GENES%WIKIPATHWAYS_20190610%WP3594%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3594_r102861	0.004789290268423714	0.004789290268423714	+1	TP53,PTEN,EP300,SIN3A,EGR3,NCOR1,EZH2
NEGATIVE REGULATION OF SISTER CHROMATID SEGREGATION%GOBP%GO:0033046	negative regulation of sister chromatid segregation	0.004873679296076129	0.004873679296076129	+1	APC,ATM,ATRX
PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY	PID_IL3_PATHWAY	0.004873679296076129	0.004873679296076129	+1	PIK3CA,PIK3R1,PTPN11
ST_GRANULE_CELL_SURVIVAL_PATHWAY%MSIGDB_C2%ST_GRANULE_CELL_SURVIVAL_PATHWAY	ST_GRANULE_CELL_SURVIVAL_PATHWAY	0.004873679296076129	0.004873679296076129	+1	APC,MAP2K4,MAPK8IP1
SIG_IL4RECEPTOR_IN_B_LYPHOCYTES%MSIGDB_C2%SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	0.004873679296076129	0.004873679296076129	+1	PIK3CA,PIK3R1,AKT1
BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY	BIOCARTA_CREB_PATHWAY	0.004873679296076129	0.004873679296076129	+1	PIK3CA,PIK3R1,AKT1
CELLULAR RESPONSE TO EPIDERMAL GROWTH FACTOR STIMULUS%GOBP%GO:0071364	cellular response to epidermal growth factor stimulus	0.004873679296076129	0.004873679296076129	+1	EGFR,SOX9,PTPN11
NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-HSA-5654733.1	Negative regulation of FGFR4 signaling	0.004873679296076129	0.004873679296076129	+1	BRAF,PPP2R1A,PTPN11
POSITIVE REGULATION OF PROTEIN LOCALIZATION TO MEMBRANE%GOBP%GO:1905477	positive regulation of protein localization to membrane	0.004981157339684393	0.004981157339684393	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1
REGULATION OF MUSCLE CELL DIFFERENTIATION%GOBP%GO:0051147	regulation of muscle cell differentiation	0.004981157339684393	0.004981157339684393	+1	NOTCH1,CTNNB1,KIT,FGFR2,SMAD4
POSITIVE REGULATION OF CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	0.005031421505321428	0.005031421505321428	+1	NOTCH1,TGFBR2
CARDIAC CELL FATE COMMITMENT%GOBP%GO:0060911	cardiac cell fate commitment	0.005031421505321428	0.005031421505321428	+1	WT1,SOX17
NEGATIVE REGULATION OF OLIGODENDROCYTE DIFFERENTIATION%GOBP%GO:0048715	negative regulation of oligodendrocyte differentiation	0.005031421505321428	0.005031421505321428	+1	NF1,NOTCH1
CELLULAR RESPONSE TO GONADOTROPIN STIMULUS%GOBP%GO:0071371	cellular response to gonadotropin stimulus	0.005031421505321428	0.005031421505321428	+1	NOTCH1,WT1
SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 69%2428933	SHC-related events triggered by IGF1R	0.005031421505321428	0.005031421505321428	+1	KRAS,NRAS
ATRIOVENTRICULAR VALVE FORMATION%GOBP%GO:0003190	atrioventricular valve formation	0.005031421505321428	0.005031421505321428	+1	NOTCH1,SMAD4
NEPHRON TUBULE FORMATION%GOBP%GO:0072079	nephron tubule formation	0.005031421505321428	0.005031421505321428	+1	GATA3,SOX9
ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME%R-HSA-9026519.1	Activated NTRK2 signals through RAS	0.005031421505321428	0.005031421505321428	+1	KRAS,NRAS
RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME DATABASE ID RELEASE 69%8941332	RUNX2 regulates genes involved in cell migration	0.005031421505321428	0.005031421505321428	+1	AKT1,CBFB
IMMATURE B CELL DIFFERENTIATION%GOBP%GO:0002327	immature B cell differentiation	0.005031421505321428	0.005031421505321428	+1	ATM,KIT
SMAD PROTEIN COMPLEX ASSEMBLY%GOBP%GO:0007183	SMAD protein complex assembly	0.005031421505321428	0.005031421505321428	+1	SMAD4,SMAD2
LOCOMOTOR RHYTHM%GOBP%GO:0045475	locomotor rhythm	0.005031421505321428	0.005031421505321428	+1	PTEN,NCOR1
MULTICELLULAR ORGANISM AGING%GOBP%GO:0010259	multicellular organism aging	0.005031421505321428	0.005031421505321428	+1	TP53,LRRK2
DIGESTIVE SYSTEM DEVELOPMENT%GOBP%GO:0055123	digestive system development	0.005031421505321428	0.005031421505321428	+1	KIT,PDGFRA,FGFR2,SOX17
BEHAVIOR%GOBP%GO:0007610	behavior	0.005241969230833925	0.005241969230833925	+1	TP53,PTEN,EGFR,NF1,LRRK2,FOXA2,NCOR1
REGULATION OF PROTEIN LOCALIZATION TO MEMBRANE%GOBP%GO:1905475	regulation of protein localization to membrane	0.005280948622866103	0.005280948622866103	+1	TP53,EGFR,PIK3R1,EPHA3,AKT1,AR
POSITIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION%GOBP%GO:0045621	positive regulation of lymphocyte differentiation	0.005280948622866103	0.005280948622866103	+1	GATA3,RUNX1,TGFBR2,CBFB
REGULATION OF MITOCHONDRION ORGANIZATION%GOBP%GO:0010821	regulation of mitochondrion organization	0.005280948622866103	0.005280948622866103	+1	TP53,FBXW7,BAP1,AKT1,HGF,LRRK2
EAR DEVELOPMENT%GOBP%GO:0043583	ear development	0.005280948622866103	0.005280948622866103	+1	GATA3,SOX9,FGFR2,PTPN11
NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 69%350054	Notch-HLH transcription pathway	0.00528931996427879	0.00528931996427879	+1	NOTCH1,TBL1XR1,NCOR1
POSITIVE REGULATION OF KIDNEY DEVELOPMENT%GOBP%GO:0090184	positive regulation of kidney development	0.00528931996427879	0.00528931996427879	+1	GATA3,SOX9,WT1
POSITIVE REGULATION OF HISTONE METHYLATION%GOBP%GO:0031062	positive regulation of histone methylation	0.00528931996427879	0.00528931996427879	+1	CTNNB1,BRCA1,SMAD4
NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME%R-HSA-5654727.1	Negative regulation of FGFR2 signaling	0.00528931996427879	0.00528931996427879	+1	BRAF,PPP2R1A,PTPN11
NEGATIVE REGULATION OF CHROMOSOME SEGREGATION%GOBP%GO:0051985	negative regulation of chromosome segregation	0.00528931996427879	0.00528931996427879	+1	APC,ATM,ATRX
BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY	BIOCARTA_GH_PATHWAY	0.00528931996427879	0.00528931996427879	+1	PIK3CA,PIK3R1,PIK3CG
REGULATION OF ANDROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0060765	regulation of androgen receptor signaling pathway	0.00528931996427879	0.00528931996427879	+1	EP300,TAF1,NCOR1
REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY	Reelin signaling pathway	0.00528931996427879	0.00528931996427879	+1	PIK3CA,PIK3R1,AKT1
ANTERIOR/POSTERIOR AXIS SPECIFICATION%GOBP%GO:0009948	anterior/posterior axis specification	0.00528931996427879	0.00528931996427879	+1	TBX3,WT1,FOXA2
RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2500257.1	Resolution of Sister Chromatid Cohesion	0.005298638089326015	0.005298638089326015	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
CELLULAR RESPONSE TO NUTRIENT LEVELS%GOBP%GO:0031669	cellular response to nutrient levels	0.005406176127350414	0.005406176127350414	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
HORMONE-MEDIATED SIGNALING PATHWAY%GOBP%GO:0009755	hormone-mediated signaling pathway	0.0055200426814875	0.0055200426814875	+1	ARID1A,RB1,CTNNB1,AR,BRCA1
IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS	IL4-mediated signaling events	0.00554038394451233	0.00554038394451233	+1	PIK3CA,PIK3R1,AKT1,MTOR
REGULATION OF MITOTIC SISTER CHROMATID SEGREGATION%GOBP%GO:0033047	regulation of mitotic sister chromatid segregation	0.00554038394451233	0.00554038394451233	+1	APC,RB1,ATM,ATRX
PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY	PID_IL4_2PATHWAY	0.00554038394451233	0.00554038394451233	+1	PIK3CA,PIK3R1,AKT1,MTOR
TRANSMEMBRANE RECEPTOR PROTEIN SERINE/THREONINE KINASE SIGNALING PATHWAY%GOBP%GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.005563637279786874	0.005563637279786874	+1	SMAD4,USP9X,TGFBR2,ACVR1B,ACVR2A,SMAD2
NEGATIVE REGULATION OF CELL ADHESION%GOBP%GO:0007162	negative regulation of cell adhesion	0.005729752946608615	0.005729752946608615	+1	PTEN,CDKN2A,NOTCH1,CDH1,RUNX1,AKT1,CBFB
NEGATIVE REGULATION OF HEMOPOIESIS%GOBP%GO:1903707	negative regulation of hemopoiesis	0.005729752946608615	0.005729752946608615	+1	NOTCH1,FBXW7,RUNX1,TLR4,CBFB
SENSORY ORGAN DEVELOPMENT%GOBP%GO:0007423	sensory organ development	0.005729752946608615	0.005729752946608615	+1	NF1,GATA3,SOX9,WT1,PDGFRA,FGFR2,PTPN11
NEPHRON TUBULE MORPHOGENESIS%GOBP%GO:0072078	nephron tubule morphogenesis	0.0057876102485554005	0.0057876102485554005	+1	GATA3,SOX9,WT1
BETA-CATENIN-TCF COMPLEX ASSEMBLY%GOBP%GO:1904837	beta-catenin-TCF complex assembly	0.0057876102485554005	0.0057876102485554005	+1	CTNNB1,EP300,AXIN2
REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.1	Regulation of MECP2 expression and activity	0.0057876102485554005	0.0057876102485554005	+1	SIN3A,TBL1XR1,NCOR1
ENDOCARDIAL CUSHION MORPHOGENESIS%GOBP%GO:0003203	endocardial cushion morphogenesis	0.0057876102485554005	0.0057876102485554005	+1	NOTCH1,SOX9,TGFBR2
BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY	BIOCARTA_TNFR1_PATHWAY	0.0057876102485554005	0.0057876102485554005	+1	RB1,MAP3K1,MAP2K4
NANOPARTICLE-MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20190610%WP2643%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2643_r102132	0.0057876102485554005	0.0057876102485554005	+1	KRAS,EGFR,NRAS
TNFALPHA%IOB%TNFALPHA	TNFalpha	0.005850530144208725	0.005850530144208725	+1	TP53,EGFR,RB1,FBXW7,MAP3K1,AKT1,PTPN11
EPITHELIAL CELL MIGRATION%GOBP%GO:0010631	epithelial cell migration	0.006172881765204001	0.006172881765204001	+1	PIK3CA,AKT1,KIT,EGR3
SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 69%187687	Signalling to ERKs	0.006320181725237428	0.006320181725237428	+1	KRAS,NRAS,BRAF
RESPONSE TO EPIDERMAL GROWTH FACTOR%GOBP%GO:0070849	response to epidermal growth factor	0.006320181725237428	0.006320181725237428	+1	EGFR,SOX9,PTPN11
BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY	BIOCARTA_FAS_PATHWAY	0.006320181725237428	0.006320181725237428	+1	RB1,MAP3K1,MAP2K4
REGULATION OF DNA-TEMPLATED TRANSCRIPTION, INITIATION%GOBP%GO:2000142	regulation of DNA-templated transcription, initiation	0.006320181725237428	0.006320181725237428	+1	TP53,CTNNB1,TAF1
NEGATIVE REGULATION OF CELL MOTILITY%GOBP%GO:2000146	negative regulation of cell motility	0.006320181725237428	0.006320181725237428	+1	PTEN,NAV3,NF1,GATA3,NOTCH1,CDH1,AKT1
PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY	PID_IL2_STAT5_PATHWAY	0.006320181725237428	0.006320181725237428	+1	PIK3CA,PIK3R1,PTPN11
PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY	PID_RAS_PATHWAY	0.006320181725237428	0.006320181725237428	+1	KRAS,NF1,NRAS
AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009	Axon guidance mediated by netrin	0.006320181725237428	0.006320181725237428	+1	PIK3CA,PIK3R1,PIK3CG
PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY	PID_EPHRINB_REV_PATHWAY	0.006320181725237428	0.006320181725237428	+1	PIK3CA,PIK3R1,MAP2K4
IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5	IL2 signaling events mediated by STAT5	0.006320181725237428	0.006320181725237428	+1	PIK3CA,PIK3R1,PTPN11
FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME DATABASE ID RELEASE 69%9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.006320181725237428	0.006320181725237428	+1	SMAD4,SIN3A,SMAD2
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.2	Regulation of TP53 Activity through Acetylation	0.006320181725237428	0.006320181725237428	+1	TP53,AKT1,EP300
STRESS-INDUCED PREMATURE SENESCENCE%GOBP%GO:0090400	stress-induced premature senescence	0.006352136570055761	0.006352136570055761	+1	TP53,CDKN1A
ENTRY OF BACTERIUM INTO HOST CELL%GOBP%GO:0035635	entry of bacterium into host cell	0.006352136570055761	0.006352136570055761	+1	CTNNB1,CDH1
DNA DAMAGE INDUCED PROTEIN PHOSPHORYLATION%GOBP%GO:0006975	DNA damage induced protein phosphorylation	0.006352136570055761	0.006352136570055761	+1	ATM,CHEK2
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.1	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	0.006352136570055761	0.006352136570055761	+1	RUNX1,CBFB
DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20190610%WP3300%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3300_r102277	0.006352136570055761	0.006352136570055761	+1	RUNX1,CBFB
MAMMARY GLAND EPITHELIAL CELL DIFFERENTIATION%GOBP%GO:0060644	mammary gland epithelial cell differentiation	0.006352136570055761	0.006352136570055761	+1	AKT1,ERBB4
REGULATION OF MAMMARY GLAND EPITHELIAL CELL PROLIFERATION%GOBP%GO:0033599	regulation of mammary gland epithelial cell proliferation	0.006352136570055761	0.006352136570055761	+1	GATA3,BRCA2
RUNX3 REGULATES WNT SIGNALING%REACTOME%R-HSA-8951430.1	RUNX3 regulates WNT signaling	0.006352136570055761	0.006352136570055761	+1	CTNNB1,CCND1
BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.2	Binding of TCF LEF:CTNNB1 to target gene promoters	0.006352136570055761	0.006352136570055761	+1	CTNNB1,AXIN2
PHOSPHATIDYLINOSITOL-3-PHOSPHATE BIOSYNTHETIC PROCESS%GOBP%GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	0.006352136570055761	0.006352136570055761	+1	PIK3CA,PIK3CG
POSITIVE REGULATION OF CELL-CELL ADHESION MEDIATED BY CADHERIN%GOBP%GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	0.006352136570055761	0.006352136570055761	+1	FOXA1,FOXA2
AXIS ELONGATION%GOBP%GO:0003401	axis elongation	0.006352136570055761	0.006352136570055761	+1	SOX9,FGFR2
REGULATION OF ENDODEOXYRIBONUCLEASE ACTIVITY%GOBP%GO:0032071	regulation of endodeoxyribonuclease activity	0.006352136570055761	0.006352136570055761	+1	NPM1,AKT1
RESPONSE TO GONADOTROPIN%GOBP%GO:0034698	response to gonadotropin	0.006352136570055761	0.006352136570055761	+1	NOTCH1,WT1
CELLULAR RESPONSE TO UV-B%GOBP%GO:0071493	cellular response to UV-B	0.006352136570055761	0.006352136570055761	+1	STK11,CDKN1A
HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK	HIF-1-alpha transcription factor network	0.006388822184102033	0.006388822184102033	+1	NPM1,AKT1,EP300,SMAD4
SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.2	Senescence-Associated Secretory Phenotype (SASP)	0.006540762086575511	0.006540762086575511	+1	CDKN2A,CDKN1B,CDKN1A,HIST1H2BD,CDKN2C
RAS PROTEIN SIGNAL TRANSDUCTION%GOBP%GO:0007265	Ras protein signal transduction	0.006673392334837344	0.006673392334837344	+1	TP53,KRAS,NF1,CDKN2A,RB1,NRAS,CDKN1A
EPITHELIUM MIGRATION%GOBP%GO:0090132	epithelium migration	0.006738502565418275	0.006738502565418275	+1	PIK3CA,AKT1,KIT,EGR3
PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY	PID_HIF1_TFPATHWAY	0.006738502565418275	0.006738502565418275	+1	NPM1,AKT1,EP300,SMAD4
POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO STRESS%GOBP%GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	0.0067890855456115866	0.0067890855456115866	+1	TP53,NOTCH1,NFE2L2
URETERIC BUD DEVELOPMENT%GOBP%GO:0001657	ureteric bud development	0.0067890855456115866	0.0067890855456115866	+1	GATA3,WT1,FGFR2
TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.1	TGF-beta receptor signaling activates SMADs	0.0067890855456115866	0.0067890855456115866	+1	SMAD4,TGFBR2,SMAD2
NEGATIVE REGULATION OF ORGANELLE ASSEMBLY%GOBP%GO:1902116	negative regulation of organelle assembly	0.0067890855456115866	0.0067890855456115866	+1	BRCA1,LRRK2,SMAD4
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 69%4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.0067890855456115866	0.0067890855456115866	+1	APC,CTNNB1,PPP2R1A
PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY	PID_CD40_PATHWAY	0.0067890855456115866	0.0067890855456115866	+1	MAP3K1,MAP2K4,AKT1
NEGATIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:0048662	negative regulation of smooth muscle cell proliferation	0.0067890855456115866	0.0067890855456115866	+1	PTEN,CDKN1B,CDKN1A
NEGATIVE REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	0.0067890855456115866	0.0067890855456115866	+1	CRIPAK,BRCA1,NCOR1
OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS	Osteopontin-mediated events	0.0067890855456115866	0.0067890855456115866	+1	PIK3CA,PIK3R1,MAP3K1
PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY	PID_AVB3_OPN_PATHWAY	0.0067890855456115866	0.0067890855456115866	+1	PIK3CA,PIK3R1,MAP3K1
AMEBOIDAL-TYPE CELL MIGRATION%GOBP%GO:0001667	ameboidal-type cell migration	0.006995944893915194	0.006995944893915194	+1	PIK3CA,AKT1,ERBB4,KIT,EGR3
REGULATION OF DNA REPAIR%GOBP%GO:0006282	regulation of DNA repair	0.006995944893915194	0.006995944893915194	+1	EGFR,BRCA1,POLQ,SETD2,AXIN2
HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-HSA-5685942.1	HDR through Homologous Recombination (HRR)	0.007026367744120366	0.007026367744120366	+1	ATM,BRCA1,BRCA2,ATR
REGULATION OF STRIATED MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0016202	regulation of striated muscle tissue development	0.007026367744120366	0.007026367744120366	+1	NOTCH1,ERBB4,FGFR2,SMAD4
NEGATIVE REGULATION OF LEUKOCYTE DIFFERENTIATION%GOBP%GO:1902106	negative regulation of leukocyte differentiation	0.007026367744120366	0.007026367744120366	+1	FBXW7,RUNX1,TLR4,CBFB
SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%HUMANCYC%PWY-6371	superpathway of inositol phosphate compounds	0.007026367744120366	0.007026367744120366	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
NEGATIVE REGULATION OF RESPONSE TO WOUNDING%GOBP%GO:1903035	negative regulation of response to wounding	0.007026367744120366	0.007026367744120366	+1	PTEN,CDKN1B,PDGFRA,CDKN1A
INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034	Integrin signalling pathway	0.0070388296623501686	0.0070388296623501686	+1	PIK3CA,PIK3R1,NRAS,MAP2K4,BRAF,PIK3CG
CELLULAR RESPONSE TO OXIDATIVE STRESS%GOBP%GO:0034599	cellular response to oxidative stress	0.007251302810935389	0.007251302810935389	+1	TP53,EGFR,NFE2L2,AKT1,LRRK2,PDGFRA
PHOSPHATIDYLINOSITOL PHOSPHORYLATION%GOBP%GO:0046854	phosphatidylinositol phosphorylation	0.007326883379520517	0.007326883379520517	+1	PIK3CA,PIK3R1,PIK3CG
REGULATION OF MUSCLE TISSUE DEVELOPMENT%GOBP%GO:1901861	regulation of muscle tissue development	0.007326883379520517	0.007326883379520517	+1	NOTCH1,ERBB4,FGFR2,SMAD4
NEGATIVE REGULATION OF JNK CASCADE%GOBP%GO:0046329	negative regulation of JNK cascade	0.007326883379520517	0.007326883379520517	+1	MAPK8IP1,MECOM,NCOR1
NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL%GOBP%GO:1903321	negative regulation of protein modification by small protein conjugation or removal	0.007326883379520517	0.007326883379520517	+1	CTNNB1,AKT1,TAF1,RPL5
REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION%GOBP%GO:1903747	regulation of establishment of protein localization to mitochondrion	0.007326883379520517	0.007326883379520517	+1	TP53,FBXW7,BAP1,LRRK2
OVARIAN INFERTILITY GENES%WIKIPATHWAYS_20190610%WP34%HOMO SAPIENS	http://www.wikipathways.org/instance/WP34_r88253	0.007326883379520517	0.007326883379520517	+1	ATM,CDKN1B,NCOR1
NEPHRON MORPHOGENESIS%GOBP%GO:0072028	nephron morphogenesis	0.007326883379520517	0.007326883379520517	+1	GATA3,SOX9,WT1
P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING	p75(NTR)-mediated signaling	0.007326883379520517	0.007326883379520517	+1	TP53,PIK3CA,PIK3R1,AKT1
GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20190610%WP2363%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2363_r101907	0.007326883379520517	0.007326883379520517	+1	TP53,EGFR,CTNNB1
MESONEPHRIC EPITHELIUM DEVELOPMENT%GOBP%GO:0072163	mesonephric epithelium development	0.007326883379520517	0.007326883379520517	+1	GATA3,WT1,FGFR2
NEPHRON EPITHELIUM MORPHOGENESIS%GOBP%GO:0072088	nephron epithelium morphogenesis	0.007326883379520517	0.007326883379520517	+1	GATA3,SOX9,WT1
RENAL TUBULE MORPHOGENESIS%GOBP%GO:0061333	renal tubule morphogenesis	0.007326883379520517	0.007326883379520517	+1	GATA3,SOX9,WT1
MESONEPHRIC TUBULE DEVELOPMENT%GOBP%GO:0072164	mesonephric tubule development	0.007326883379520517	0.007326883379520517	+1	GATA3,WT1,FGFR2
NEGATIVE REGULATION OF NOTCH SIGNALING PATHWAY%GOBP%GO:0045746	negative regulation of Notch signaling pathway	0.007326883379520517	0.007326883379520517	+1	EGFR,FBXW7,AKT1
G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 69%69481	G2 M Checkpoints	0.007611269722417359	0.007611269722417359	+1	TP53,ATM,BRCA1,CHEK2,ATR,HIST1H2BD
ENDOTHELIUM DEVELOPMENT%GOBP%GO:0003158	endothelium development	0.007707059308710816	0.007707059308710816	+1	NOTCH1,CTNNB1,SMAD4,SOX17
REGULATION OF TYPE I INTERFERON PRODUCTION%GOBP%GO:0032479	regulation of type I interferon production	0.007707059308710816	0.007707059308710816	+1	CTNNB1,TLR4,SETD2,EP300,PTPN11
PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY	PID_P75_NTR_PATHWAY	0.007707059308710816	0.007707059308710816	+1	TP53,PIK3CA,PIK3R1,AKT1
INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 69%8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.007775490857863813	0.007775490857863813	+1	CTNNB1,CDH1
MONOUBIQUITINATED PROTEIN DEUBIQUITINATION%GOBP%GO:0035520	monoubiquitinated protein deubiquitination	0.007775490857863813	0.007775490857863813	+1	BAP1,ASXL1
CELLULAR RESPONSE TO OXIDISED LOW-DENSITY LIPOPROTEIN PARTICLE STIMULUS%GOBP%GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	0.007775490857863813	0.007775490857863813	+1	AKT1,TLR4
NODAL SIGNALING PATHWAY%GOBP%GO:0038092	nodal signaling pathway	0.007775490857863813	0.007775490857863813	+1	ACVR1B,SMAD2
PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 69%1250342	PI3K events in ERBB4 signaling	0.007775490857863813	0.007775490857863813	+1	PIK3CA,PIK3R1
REGULATION OF NEPHRON TUBULE EPITHELIAL CELL DIFFERENTIATION%GOBP%GO:0072182	regulation of nephron tubule epithelial cell differentiation	0.007775490857863813	0.007775490857863813	+1	GATA3,CTNNB1
REGULATION OF GONAD DEVELOPMENT%GOBP%GO:1905939	regulation of gonad development	0.007775490857863813	0.007775490857863813	+1	SOX9,WT1
PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 69%6811555	PI5P Regulates TP53 Acetylation	0.007775490857863813	0.007775490857863813	+1	TP53,EP300
MAST CELL DEGRANULATION%GOBP%GO:0043303	mast cell degranulation	0.007775490857863813	0.007775490857863813	+1	PIK3CG,KIT
EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS	EGFR-dependent Endothelin signaling events	0.007775490857863813	0.007775490857863813	+1	EGFR,MTOR
PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.3	PI3K AKT activation	0.007775490857863813	0.007775490857863813	+1	PIK3CA,PIK3R1
EMBRYONIC DIGESTIVE TRACT MORPHOGENESIS%GOBP%GO:0048557	embryonic digestive tract morphogenesis	0.007775490857863813	0.007775490857863813	+1	PDGFRA,FGFR2
MAST CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE%GOBP%GO:0002279	mast cell activation involved in immune response	0.007775490857863813	0.007775490857863813	+1	PIK3CG,KIT
REGULATION OF MYOBLAST DIFFERENTIATION%GOBP%GO:0045661	regulation of myoblast differentiation	0.007831241959835743	0.007831241959835743	+1	NOTCH1,TBX3,SOX9
RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20190610%WP4481%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4481_r102529	0.007831241959835743	0.007831241959835743	+1	PIK3CA,AKT1,PIK3CG
REGULATION OF PRI-MIRNA TRANSCRIPTION BY RNA POLYMERASE II%GOBP%GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	0.007831241959835743	0.007831241959835743	+1	TP53,SOX9,WT1
POSITIVE REGULATION OF ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0046638	positive regulation of alpha-beta T cell differentiation	0.007831241959835743	0.007831241959835743	+1	RUNX1,TGFBR2,CBFB
BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY	BIOCARTA_AT1R_PATHWAY	0.007831241959835743	0.007831241959835743	+1	EGFR,MAP3K1,MAP2K4
LIVER DEVELOPMENT%GOBP%GO:0001889	liver development	0.007831241959835743	0.007831241959835743	+1	NF1,CEBPA,ARID5B
RESPONSE TO ESTRADIOL%GOBP%GO:0032355	response to estradiol	0.007831241959835743	0.007831241959835743	+1	EGFR,CTNNB1,FOXA1
REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION	Regulation of Ras family activation	0.007831241959835743	0.007831241959835743	+1	KRAS,NF1,NRAS
RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME DATABASE ID RELEASE 69%5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.007831241959835743	0.007831241959835743	+1	ATM,BRCA1,BRCA2
WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20190610%WP4149%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4149_r94399	0.007831241959835743	0.007831241959835743	+1	GATA3,CEBPA,MECOM
PLATELET ACTIVATION%GOBP%GO:0030168	platelet activation	0.007850424601516382	0.007850424601516382	+1	PIK3CA,PIK3R1,PIK3CG,PDGFRA,PTPN11
DNA REPLICATION%GOBP%GO:0006260	DNA replication	0.007902744223089862	0.007902744223089862	+1	ATM,ATRX,BRCA1,POLQ,BRCA2,ATR
TISSUE MIGRATION%GOBP%GO:0090130	tissue migration	0.007949469939924821	0.007949469939924821	+1	PIK3CA,AKT1,KIT,EGR3
HISTONE MODIFICATIONS%WIKIPATHWAYS_20190610%WP2369%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2369_r102995	0.007949469939924821	0.007949469939924821	+1	SETBP1,SETD2,NSD1,EZH2
HOMEOSTASIS OF NUMBER OF CELLS%GOBP%GO:0048872	homeostasis of number of cells	0.007949469939924821	0.007949469939924821	+1	FLT3,AKT1,SOX9,KIT
REGULATION OF OSSIFICATION%GOBP%GO:0030278	regulation of ossification	0.008106579693440828	0.008106579693440828	+1	NOTCH1,SOX9,HGF,FGFR2,ACVR2A
INTRACELLULAR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0030522	intracellular receptor signaling pathway	0.008106579693440828	0.008106579693440828	+1	ARID1A,RB1,CTNNB1,AR,BRCA1
NUCLEAR CHROMOSOME SEGREGATION%GOBP%GO:0098813	nuclear chromosome segregation	0.008106579693440828	0.008106579693440828	+1	RB1,FBXW7,STAG2,SMC1A,SMC3,RAD21
REGULATION OF NEURON DEATH%GOBP%GO:1901214	regulation of neuron death	0.008322470691161064	0.008322470691161064	+1	NF1,FBXW7,CTNNB1,AKT1,TLR4,LRRK2
INSULIN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0008286	insulin receptor signaling pathway	0.008322470691161064	0.008322470691161064	+1	PIK3CA,APC,PIK3R1,AKT1
PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 69%3214841	PKMTs methylate histone lysines	0.008322470691161064	0.008322470691161064	+1	SETD2,NSD1,MECOM,EZH2
TRANSCRIPTION ELONGATION FROM RNA POLYMERASE II PROMOTER%GOBP%GO:0006368	transcription elongation from RNA polymerase II promoter	0.008322470691161064	0.008322470691161064	+1	PBRM1,SETD2,CDK12,ERCC2
SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.2	Signaling by NOTCH1	0.008322470691161064	0.008322470691161064	+1	NOTCH1,EP300,TBL1XR1,NCOR1
CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.4	Cell-Cell communication	0.008358795948534057	0.008358795948534057	+1	PIK3CA,PIK3R1,CTNNB1,CDH1,PTPN11
IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS	IL8- and CXCR2-mediated signaling events	0.008358795948534057	0.008358795948534057	+1	AKT1,PIK3CG,PPP2R1A
PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY	PID_IL8_CXCR2_PATHWAY	0.008358795948534057	0.008358795948534057	+1	AKT1,PIK3CG,PPP2R1A
HEPATICOBILIARY SYSTEM DEVELOPMENT%GOBP%GO:0061008	hepaticobiliary system development	0.008358795948534057	0.008358795948534057	+1	NF1,CEBPA,ARID5B
SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802948.1	Signaling by high-kinase activity BRAF mutants	0.008358795948534057	0.008358795948534057	+1	KRAS,NRAS,BRAF
TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY	Trk receptor signaling mediated by the MAPK pathway	0.008358795948534057	0.008358795948534057	+1	KRAS,NRAS,BRAF
PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY	PID_MAPK_TRK_PATHWAY	0.008358795948534057	0.008358795948534057	+1	KRAS,NRAS,BRAF
REGULATION OF VASCULAR SMOOTH MUSCLE CELL PROLIFERATION%GOBP%GO:1904705	regulation of vascular smooth muscle cell proliferation	0.008358795948534057	0.008358795948534057	+1	PTEN,CDKN1B,CDKN1A
REGULATION OF GLUCOSE IMPORT%GOBP%GO:0046324	regulation of glucose import	0.008358795948534057	0.008358795948534057	+1	PIK3R1,AKT1,PTPN11
NEGATIVE REGULATION OF MITOTIC NUCLEAR DIVISION%GOBP%GO:0045839	negative regulation of mitotic nuclear division	0.008358795948534057	0.008358795948534057	+1	APC,ATM,ATRX
SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 69%4791275	Signaling by WNT in cancer	0.008358795948534057	0.008358795948534057	+1	APC,CTNNB1,PPP2R1A
RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-HSA-5693537.1	Resolution of D-Loop Structures	0.008358795948534057	0.008358795948534057	+1	ATM,BRCA1,BRCA2
ENDOCARDIAL CUSHION DEVELOPMENT%GOBP%GO:0003197	endocardial cushion development	0.008358795948534057	0.008358795948534057	+1	NOTCH1,SOX9,TGFBR2
FEMALE SEX DIFFERENTIATION%GOBP%GO:0046660	female sex differentiation	0.008358795948534057	0.008358795948534057	+1	TBX3,KIT,PDGFRA
VENTRICULAR CARDIAC MUSCLE TISSUE MORPHOGENESIS%GOBP%GO:0055010	ventricular cardiac muscle tissue morphogenesis	0.008358795948534057	0.008358795948534057	+1	NOTCH1,FGFR2,SMAD4
REGULATION OF ALPHA-BETA T CELL ACTIVATION%GOBP%GO:0046634	regulation of alpha-beta T cell activation	0.008633490223017012	0.008633490223017012	+1	RUNX1,TGFBR2,CBFB,MAPK8IP1
REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT%GOBP%GO:0046822	regulation of nucleocytoplasmic transport	0.008633490223017012	0.008633490223017012	+1	TP53,PIK3R1,CDH1,SETD2
REGULATION OF OSTEOBLAST DIFFERENTIATION%GOBP%GO:0045667	regulation of osteoblast differentiation	0.008633490223017012	0.008633490223017012	+1	NOTCH1,HGF,FGFR2,ACVR2A
REGULATION OF MUSCLE ORGAN DEVELOPMENT%GOBP%GO:0048634	regulation of muscle organ development	0.008633490223017012	0.008633490223017012	+1	NOTCH1,ERBB4,FGFR2,SMAD4
POSITIVE REGULATION OF MITOTIC CELL CYCLE%GOBP%GO:0045931	positive regulation of mitotic cell cycle	0.00888089687684326	0.00888089687684326	+1	EGFR,RB1,AKT1,FOXA1,CCND1
NEGATIVE REGULATION OF CELL DEVELOPMENT%GOBP%GO:0010721	negative regulation of cell development	0.008916061046501823	0.008916061046501823	+1	PTEN,NF1,NOTCH1,FBXW7,SOX9,SMAD4
NEGATIVE REGULATION OF MITOCHONDRION ORGANIZATION%GOBP%GO:0010823	negative regulation of mitochondrion organization	0.009008667269476262	0.009008667269476262	+1	AKT1,HGF,LRRK2
INTRINSIC APOPTOTIC SIGNALING PATHWAY BY P53 CLASS MEDIATOR%GOBP%GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	0.009008667269476262	0.009008667269476262	+1	TP53,STK11,EP300
NEPHRON TUBULE DEVELOPMENT%GOBP%GO:0072080	nephron tubule development	0.009008667269476262	0.009008667269476262	+1	GATA3,SOX9,WT1
ST_G_ALPHA_I_PATHWAY%MSIGDB_C2%ST_G_ALPHA_I_PATHWAY	ST_G_ALPHA_I_PATHWAY	0.009008667269476262	0.009008667269476262	+1	EGFR,AKT1,BRAF
ROOF OF MOUTH DEVELOPMENT%GOBP%GO:0060021	roof of mouth development	0.009008667269476262	0.009008667269476262	+1	SMAD4,TGFBR2,SMAD2
BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY	BIOCARTA_CARM_ER_PATHWAY	0.009008667269476262	0.009008667269476262	+1	BRCA1,EP300,CCND1
NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS%GOBP%GO:0032102	negative regulation of response to external stimulus	0.009130053863379185	0.009130053863379185	+1	PTEN,GATA3,RB1,NOTCH1,CDKN1B,PDGFRA,CDKN1A
POSITIVE REGULATION OF PRODUCTION OF MIRNAS INVOLVED IN GENE SILENCING BY MIRNA%GOBP%GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	0.009208406655136366	0.009208406655136366	+1	TP53,EGFR
MAMMARY GLAND MORPHOGENESIS%GOBP%GO:0060443	mammary gland morphogenesis	0.009208406655136366	0.009208406655136366	+1	ELF3,FGFR2
RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-HSA-5626467.1	RHO GTPases activate IQGAPs	0.009208406655136366	0.009208406655136366	+1	CTNNB1,CDH1
REGULATION OF DEOXYRIBONUCLEASE ACTIVITY%GOBP%GO:0032070	regulation of deoxyribonuclease activity	0.009208406655136366	0.009208406655136366	+1	NPM1,AKT1
MAST CELL MEDIATED IMMUNITY%GOBP%GO:0002448	mast cell mediated immunity	0.009208406655136366	0.009208406655136366	+1	PIK3CG,KIT
MAMMARY GLAND DEVELOPMENT PATHWAY - INVOLUTION (STAGE 4 OF 4)%WIKIPATHWAYS_20190610%WP2815%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2815_r102408	0.009208406655136366	0.009208406655136366	+1	TP53,CDH1
INSULIN-LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0048009	insulin-like growth factor receptor signaling pathway	0.009208406655136366	0.009208406655136366	+1	PIK3R1,AKT1
HEMATOPOIETIC STEM CELL PROLIFERATION%GOBP%GO:0071425	hematopoietic stem cell proliferation	0.009208406655136366	0.009208406655136366	+1	RUNX1,MECOM
REGULATION OF CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0062042	regulation of cardiac epithelial to mesenchymal transition	0.009208406655136366	0.009208406655136366	+1	NOTCH1,TGFBR2
POSITIVE REGULATION OF OXIDATIVE STRESS-INDUCED CELL DEATH%GOBP%GO:1903209	positive regulation of oxidative stress-induced cell death	0.009208406655136366	0.009208406655136366	+1	FBXW7,TLR4
REGULATION OF CELL PROLIFERATION INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:1901722	regulation of cell proliferation involved in kidney development	0.009208406655136366	0.009208406655136366	+1	GATA3,WT1
NEGATIVE REGULATION OF INTRACELLULAR ESTROGEN RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	0.009208406655136366	0.009208406655136366	+1	CRIPAK,BRCA1
RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.1	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	0.009208406655136366	0.009208406655136366	+1	RUNX1,CBFB
DOUBLE-STRAND BREAK REPAIR%GOBP%GO:0006302	double-strand break repair	0.009288017236389222	0.009288017236389222	+1	ATM,BRCA1,POLQ,CHEK2,BRCA2,RAD21
NEPHRON DEVELOPMENT%GOBP%GO:0072006	nephron development	0.009364080280578706	0.009364080280578706	+1	GATA3,SOX9,WT1,PDGFRA
REGULATION OF CELL JUNCTION ASSEMBLY%GOBP%GO:1901888	regulation of cell junction assembly	0.009364080280578706	0.009364080280578706	+1	PTEN,RUNX1,EPHA3,CBFB
RESPONSE TO STEROID HORMONE%GOBP%GO:0048545	response to steroid hormone	0.009364288245264297	0.009364288245264297	+1	ARID1A,RB1,CTNNB1,AR,BRCA1
REGULATION OF STEM CELL PROLIFERATION%GOBP%GO:0072091	regulation of stem cell proliferation	0.009598634916721086	0.009598634916721086	+1	NF1,CTNNB1,LRRK2
CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS%GOBP%GO:0035924	cellular response to vascular endothelial growth factor stimulus	0.009598634916721086	0.009598634916721086	+1	NOTCH1,PDGFRA,EGR3
VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0003229	ventricular cardiac muscle tissue development	0.009598634916721086	0.009598634916721086	+1	NOTCH1,FGFR2,SMAD4
REGULATION OF MITOTIC SPINDLE ORGANIZATION%GOBP%GO:0060236	regulation of mitotic spindle organization	0.009598634916721086	0.009598634916721086	+1	STAG2,SMC1A,SMC3
MESONEPHROS DEVELOPMENT%GOBP%GO:0001823	mesonephros development	0.009598634916721086	0.009598634916721086	+1	GATA3,WT1,FGFR2
REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION%GOBP%GO:2000177	regulation of neural precursor cell proliferation	0.009598634916721086	0.009598634916721086	+1	NF1,CTNNB1,LRRK2
RESPONSE TO OXIDATIVE STRESS%GOBP%GO:0006979	response to oxidative stress	0.009619542876623428	0.009619542876623428	+1	TP53,EGFR,NFE2L2,AKT1,LRRK2,PDGFRA,ERCC2
TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 69%166016	Toll Like Receptor 4 (TLR4) Cascade	0.009636839118969936	0.009636839118969936	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001242	regulation of intrinsic apoptotic signaling pathway	0.009636839118969936	0.009636839118969936	+1	TP53,FBXW7,NFE2L2,AKT1,LRRK2
REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA%GOBP%GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	0.00974588738357367	0.00974588738357367	+1	VHL,NOTCH1,NFE2L2,EP300
REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION%GOBP%GO:0002761	regulation of myeloid leukocyte differentiation	0.00974588738357367	0.00974588738357367	+1	FBXW7,RUNX1,MTOR,TLR4
POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY%GOBP%GO:0090263	positive regulation of canonical Wnt signaling pathway	0.009958219298063146	0.009958219298063146	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
REGULATION OF MEGAKARYOCYTE DIFFERENTIATION%GOBP%GO:0045652	regulation of megakaryocyte differentiation	0.01020368585365514	0.01020368585365514	+1	RUNX1,EP300,CBFB,SIN3A
REGULATION OF CELLULAR RESPONSE TO HEAT%GOBP%GO:1900034	regulation of cellular response to heat	0.01020368585365514	0.01020368585365514	+1	ATM,MTOR,EP300,ATR
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 69%111465	Apoptotic cleavage of cellular proteins	0.010205413123550581	0.010205413123550581	+1	APC,CTNNB1,CDH1
BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY	BIOCARTA_PAR1_PATHWAY	0.010205413123550581	0.010205413123550581	+1	PIK3CA,PIK3R1,PIK3CG
BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY	BIOCARTA_TOLL_PATHWAY	0.010205413123550581	0.010205413123550581	+1	MAP3K1,MAP2K4,TLR4
PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY	PID_FRA_PATHWAY	0.010205413123550581	0.010205413123550581	+1	CDKN2A,EP300,CCND1
POSITIVE REGULATION OF MUSCLE ORGAN DEVELOPMENT%GOBP%GO:0048636	positive regulation of muscle organ development	0.010205413123550581	0.010205413123550581	+1	NOTCH1,ERBB4,FGFR2
HEART LOOPING%GOBP%GO:0001947	heart looping	0.010205413123550581	0.010205413123550581	+1	NOTCH1,TGFBR2,SOX17
HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 69%5685938	HDR through Single Strand Annealing (SSA)	0.010205413123550581	0.010205413123550581	+1	ATM,BRCA1,ATR
STEM CELL PROLIFERATION%GOBP%GO:0072089	stem cell proliferation	0.010205413123550581	0.010205413123550581	+1	RUNX1,FGFR2,MECOM
POSITIVE REGULATION OF STRIATED MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0045844	positive regulation of striated muscle tissue development	0.010205413123550581	0.010205413123550581	+1	NOTCH1,ERBB4,FGFR2
IFN-ALPHA%IOB%IFN-ALPHA	IFN-alpha	0.010205413123550581	0.010205413123550581	+1	MAP2K4,AKT1,MTOR
POSITIVE REGULATION OF NOTCH SIGNALING PATHWAY%GOBP%GO:0045747	positive regulation of Notch signaling pathway	0.010205413123550581	0.010205413123550581	+1	NOTCH1,ELF3,EP300
VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2	Validated transcriptional targets of AP1 family members Fra1 and Fra2	0.010205413123550581	0.010205413123550581	+1	CDKN2A,EP300,CCND1
MUSCLE STRUCTURE DEVELOPMENT%GOBP%GO:0061061	muscle structure development	0.010205413123550581	0.010205413123550581	+1	RB1,NOTCH1,WT1,PDGFRA,FGFR2,SMAD4,EGR3
CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT%GOBP%GO:0021954	central nervous system neuron development	0.010205413123550581	0.010205413123550581	+1	PTEN,ARHGAP35,FGFR2
RENAL TUBULE DEVELOPMENT%GOBP%GO:0061326	renal tubule development	0.010205413123550581	0.010205413123550581	+1	GATA3,SOX9,WT1
ST_GA13_PATHWAY%MSIGDB_C2%ST_GA13_PATHWAY	ST_GA13_PATHWAY	0.010205413123550581	0.010205413123550581	+1	MAP3K1,MAP2K4,AKT1
POSITIVE REGULATION OF DEVELOPMENTAL GROWTH%GOBP%GO:0048639	positive regulation of developmental growth	0.010566737669342201	0.010566737669342201	+1	NOTCH1,WT1,ERBB4,FGFR2
NEGATIVE REGULATION OF CENTROSOME DUPLICATION%GOBP%GO:0010826	negative regulation of centrosome duplication	0.010756324656401762	0.010756324656401762	+1	NPM1,BRCA1
PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20190610%WP4147%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4147_r94394	0.010756324656401762	0.010756324656401762	+1	NOTCH1,CTNNB1
HEART VALVE FORMATION%GOBP%GO:0003188	heart valve formation	0.010756324656401762	0.010756324656401762	+1	NOTCH1,SMAD4
REGULATION OF HISTONE H3-K9 ACETYLATION%GOBP%GO:2000615	regulation of histone H3-K9 acetylation	0.010756324656401762	0.010756324656401762	+1	BRCA1,SMAD4
NEGATIVE REGULATION OF CARDIOCYTE DIFFERENTIATION%GOBP%GO:1905208	negative regulation of cardiocyte differentiation	0.010756324656401762	0.010756324656401762	+1	EGFR,SMAD4
REGULATION OF KERATINOCYTE MIGRATION%GOBP%GO:0051547	regulation of keratinocyte migration	0.010756324656401762	0.010756324656401762	+1	PTEN,MTOR
METANEPHRIC EPITHELIUM DEVELOPMENT%GOBP%GO:0072207	metanephric epithelium development	0.010756324656401762	0.010756324656401762	+1	SOX9,WT1
ADRENAL GLAND DEVELOPMENT%GOBP%GO:0030325	adrenal gland development	0.010756324656401762	0.010756324656401762	+1	NF1,WT1
PERICARDIUM DEVELOPMENT%GOBP%GO:0060039	pericardium development	0.010756324656401762	0.010756324656401762	+1	NOTCH1,WT1
MESENCHYMAL TO EPITHELIAL TRANSITION%GOBP%GO:0060231	mesenchymal to epithelial transition	0.010756324656401762	0.010756324656401762	+1	GATA3,WT1
MAST CELL ACTIVATION%GOBP%GO:0045576	mast cell activation	0.010756324656401762	0.010756324656401762	+1	PIK3CG,KIT
DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR RESULTING IN TRANSCRIPTION OF P21 CLASS MEDIATOR%GOBP%GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	0.010756324656401762	0.010756324656401762	+1	TP53,BRCA1
METANEPHRIC NEPHRON MORPHOGENESIS%GOBP%GO:0072273	metanephric nephron morphogenesis	0.010756324656401762	0.010756324656401762	+1	SOX9,WT1
POSITIVE REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway	0.010756324656401762	0.010756324656401762	+1	FOXA1,TAF1
APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 69%351906	Apoptotic cleavage of cell adhesion proteins	0.010756324656401762	0.010756324656401762	+1	CTNNB1,CDH1
REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 69%1433617	Regulation of signaling by NODAL	0.010756324656401762	0.010756324656401762	+1	ACVR1B,ACVR2A
BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY	BIOCARTA_EGFR_SMRTE_PATHWAY	0.010756324656401762	0.010756324656401762	+1	EGFR,MAP3K1
NEGATIVE REGULATION OF NEUROLOGICAL SYSTEM PROCESS%GOBP%GO:0031645	negative regulation of neurological system process	0.010756324656401762	0.010756324656401762	+1	PTEN,LRRK2
NEGATIVE REGULATION OF GLIAL CELL DIFFERENTIATION%GOBP%GO:0045686	negative regulation of glial cell differentiation	0.010756324656401762	0.010756324656401762	+1	NF1,NOTCH1
POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT%GOBP%GO:0090316	positive regulation of intracellular protein transport	0.010756324656401762	0.010756324656401762	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1
POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT%GOBP%GO:1901863	positive regulation of muscle tissue development	0.010805561839568918	0.010805561839568918	+1	NOTCH1,ERBB4,FGFR2
SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE	Signaling events regulated by Ret tyrosine kinase	0.010805561839568918	0.010805561839568918	+1	PIK3CA,PIK3R1,PTPN11
PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY	PID_RET_PATHWAY	0.010805561839568918	0.010805561839568918	+1	PIK3CA,PIK3R1,PTPN11
RET SIGNALING%REACTOME%R-HSA-8853659.4	RET signaling	0.010805561839568918	0.010805561839568918	+1	PIK3CA,PIK3R1,PTPN11
MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.1	MAP2K and MAPK activation	0.010805561839568918	0.010805561839568918	+1	KRAS,NRAS,BRAF
OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.3	Ovarian tumor domain proteases	0.010805561839568918	0.010805561839568918	+1	TP53,PTEN,APC
RESPONSE TO BMP%GOBP%GO:0071772	response to BMP	0.010835587865563753	0.010835587865563753	+1	SOX9,SMAD4,USP9X,ACVR2A
ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 69%6802957	Oncogenic MAPK signaling	0.010835587865563753	0.010835587865563753	+1	KRAS,NF1,NRAS,BRAF
CELLULAR RESPONSE TO BMP STIMULUS%GOBP%GO:0071773	cellular response to BMP stimulus	0.010835587865563753	0.010835587865563753	+1	SOX9,SMAD4,USP9X,ACVR2A
POSITIVE REGULATION OF CHROMATIN ORGANIZATION%GOBP%GO:1905269	positive regulation of chromatin organization	0.010835587865563753	0.010835587865563753	+1	CTNNB1,BRCA1,SMAD4,SIN3A
VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20190610%WP2877%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2877_r94793	0.011026668828819695	0.011026668828819695	+1	CDKN2A,CEBPA,CDKN1B,CCND1,CDKN1A,CDKN2C
REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS%GOBP%GO:1900180	regulation of protein localization to nucleus	0.01128957569999125	0.01128957569999125	+1	PIK3R1,CDH1,AKT1,SIN3A
RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.2	RMTs methylate histone arginines	0.01128957569999125	0.01128957569999125	+1	ARID1A,PBRM1,DNMT3A,CCND1
REGULATION OF DNA RECOMBINATION%GOBP%GO:0000018	regulation of DNA recombination	0.01128957569999125	0.01128957569999125	+1	POLQ,HIST1H1C,SETD2,ERCC2
PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY	PID_MYC_ACTIV_PATHWAY	0.01128957569999125	0.01128957569999125	+1	TP53,NPM1,EP300,SMAD4
REGULATORY CIRCUITS OF THE STAT3 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP4538%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4538_r104390	0.01128957569999125	0.01128957569999125	+1	EGFR,MTOR,PDGFRA,LIFR
REGULATION OF EMBRYONIC DEVELOPMENT%GOBP%GO:0045995	regulation of embryonic development	0.01128957569999125	0.01128957569999125	+1	GATA3,CTNNB1,FOXA2,SOX17
ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY	ATR signaling pathway	0.011468324383191765	0.011468324383191765	+1	BRCA2,PPP2R1A,ATR
SOMATIC STEM CELL POPULATION MAINTENANCE%GOBP%GO:0035019	somatic stem cell population maintenance	0.011468324383191765	0.011468324383191765	+1	SOX9,SMAD4,SMAD2
MTOR SIGNALLING%REACTOME%R-HSA-165159.5	mTOR signalling	0.011468324383191765	0.011468324383191765	+1	STK11,AKT1,MTOR
SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III	Signaling events mediated by HDAC Class III	0.011468324383191765	0.011468324383191765	+1	TP53,EP300,CDKN1A
REGULATION OF SPINDLE ORGANIZATION%GOBP%GO:0090224	regulation of spindle organization	0.011468324383191765	0.011468324383191765	+1	STAG2,SMC1A,SMC3
HEDGEHOG%IOB%HEDGEHOG	Hedgehog	0.011468324383191765	0.011468324383191765	+1	CTNNB1,AKT1,SIN3A
PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY	PID_ATR_PATHWAY	0.011468324383191765	0.011468324383191765	+1	BRCA2,PPP2R1A,ATR
LOCOMOTORY BEHAVIOR%GOBP%GO:0007626	locomotory behavior	0.011468324383191765	0.011468324383191765	+1	PTEN,FOXA2,NCOR1
HEDGEHOG%NETPATH%HEDGEHOG	Hedgehog	0.011468324383191765	0.011468324383191765	+1	CTNNB1,AKT1,SIN3A
FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP4136%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4136_r103640	0.011468324383191765	0.011468324383191765	+1	PIK3CA,AKT1,TLR4
VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION	Validated targets of C-MYC transcriptional activation	0.01172203307006813	0.01172203307006813	+1	TP53,NPM1,EP300,SMAD4
MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20190610%WP3937%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3937_r94208	0.01222529932315059	0.01222529932315059	+1	PIK3CA,PIK3R1,PIK3CG
POSITIVE REGULATION OF PHOSPHOLIPASE C ACTIVITY%GOBP%GO:0010863	positive regulation of phospholipase C activity	0.01222529932315059	0.01222529932315059	+1	EGFR,KIT,PDGFRA
ST_B_CELL_ANTIGEN_RECEPTOR%MSIGDB_C2%ST_B_CELL_ANTIGEN_RECEPTOR	ST_B_CELL_ANTIGEN_RECEPTOR	0.01222529932315059	0.01222529932315059	+1	PIK3CA,PIK3R1,AKT1
NEGATIVE REGULATION OF STRESS-ACTIVATED PROTEIN KINASE SIGNALING CASCADE%GOBP%GO:0070303	negative regulation of stress-activated protein kinase signaling cascade	0.01222529932315059	0.01222529932315059	+1	MAPK8IP1,MECOM,NCOR1
REGULATION OF OSTEOCLAST DIFFERENTIATION%GOBP%GO:0045670	regulation of osteoclast differentiation	0.01222529932315059	0.01222529932315059	+1	FBXW7,MTOR,TLR4
GM-CSF%IOB%GM-CSF	GM-CSF	0.01222529932315059	0.01222529932315059	+1	PIK3R1,AKT1,KIT,PTPN11
REGULATION OF HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION%GOBP%GO:1901532	regulation of hematopoietic progenitor cell differentiation	0.01222529932315059	0.01222529932315059	+1	GATA3,NOTCH1,RUNX1,CBFB
REGULATION OF PROTEIN TARGETING TO MITOCHONDRION%GOBP%GO:1903214	regulation of protein targeting to mitochondrion	0.01222529932315059	0.01222529932315059	+1	FBXW7,BAP1,LRRK2
NEGATIVE REGULATION OF NUCLEAR DIVISION%GOBP%GO:0051784	negative regulation of nuclear division	0.01222529932315059	0.01222529932315059	+1	APC,ATM,ATRX
POSITIVE REGULATION OF REPRODUCTIVE PROCESS%GOBP%GO:2000243	positive regulation of reproductive process	0.01222529932315059	0.01222529932315059	+1	SOX9,WT1,ACVR1B
NEGATIVE REGULATION OF STRESS-ACTIVATED MAPK CASCADE%GOBP%GO:0032873	negative regulation of stress-activated MAPK cascade	0.01222529932315059	0.01222529932315059	+1	MAPK8IP1,MECOM,NCOR1
ANTERIOR/POSTERIOR AXIS SPECIFICATION, EMBRYO%GOBP%GO:0008595	anterior/posterior axis specification, embryo	0.012279054389808362	0.012279054389808362	+1	TBX3,WT1
RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20190610%WP2290%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2290_r79988	0.012279054389808362	0.012279054389808362	+1	KRAS,NRAS
SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 69%5654704	SHC-mediated cascade:FGFR3	0.012279054389808362	0.012279054389808362	+1	KRAS,NRAS
NEGATIVE REGULATION OF HISTONE ACETYLATION%GOBP%GO:0035067	negative regulation of histone acetylation	0.012279054389808362	0.012279054389808362	+1	BRCA1,SIN3A
P38MAPK EVENTS%REACTOME%R-HSA-171007.3	p38MAPK events	0.012279054389808362	0.012279054389808362	+1	KRAS,NRAS
SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.3	SHC1 events in ERBB4 signaling	0.012279054389808362	0.012279054389808362	+1	KRAS,NRAS
BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY	BIOCARTA_VDR_PATHWAY	0.012279054389808362	0.012279054389808362	+1	EP300,NCOR1
NEGATIVE REGULATION OF MUSCLE HYPERTROPHY%GOBP%GO:0014741	negative regulation of muscle hypertrophy	0.012279054389808362	0.012279054389808362	+1	NOTCH1,SMAD4
HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.2	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.012279054389808362	0.012279054389808362	+1	ATM,BRCA1,BRCA2,ATR,HIST1H2BD
NEGATIVE REGULATION OF CARDIAC MUSCLE HYPERTROPHY%GOBP%GO:0010614	negative regulation of cardiac muscle hypertrophy	0.012279054389808362	0.012279054389808362	+1	NOTCH1,SMAD4
SEX DETERMINATION%GOBP%GO:0007530	sex determination	0.012279054389808362	0.012279054389808362	+1	SOX9,WT1
REGULATION OF EPITHELIAL CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:2000696	regulation of epithelial cell differentiation involved in kidney development	0.012279054389808362	0.012279054389808362	+1	GATA3,CTNNB1
DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION RESULTING IN TRANSCRIPTION%GOBP%GO:0042772	DNA damage response, signal transduction resulting in transcription	0.012279054389808362	0.012279054389808362	+1	TP53,BRCA1
SIGNAL TRANSDUCTION INVOLVED IN G2 DNA DAMAGE CHECKPOINT%GOBP%GO:0072425	signal transduction involved in G2 DNA damage checkpoint	0.012279054389808362	0.012279054389808362	+1	ATM,BRCA1
NEURON PROJECTION FASCICULATION%GOBP%GO:0106030	neuron projection fasciculation	0.012279054389808362	0.012279054389808362	+1	ARHGAP35,EPHA3
TRIPARTITE REGIONAL SUBDIVISION%GOBP%GO:0007351	tripartite regional subdivision	0.012279054389808362	0.012279054389808362	+1	TBX3,WT1
POSITIVE REGULATION OF CELLULAR RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1900409	positive regulation of cellular response to oxidative stress	0.012279054389808362	0.012279054389808362	+1	FBXW7,TLR4
RNA POLYMERASE II PREINITIATION COMPLEX ASSEMBLY%GOBP%GO:0051123	RNA polymerase II preinitiation complex assembly	0.012279054389808362	0.012279054389808362	+1	TP53,TAF1
BLASTODERM SEGMENTATION%GOBP%GO:0007350	blastoderm segmentation	0.012279054389808362	0.012279054389808362	+1	TBX3,WT1
NEGATIVE REGULATION OF MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:1905331	negative regulation of morphogenesis of an epithelium	0.012279054389808362	0.012279054389808362	+1	PTEN,GATA3
LNCRNA-MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20190610%WP3672%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3672_r96967	0.012279054389808362	0.012279054389808362	+1	TP53,CDKN1A
TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-HSA-8866910.3	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.012279054389808362	0.012279054389808362	+1	EGFR,KIT
AXONAL FASCICULATION%GOBP%GO:0007413	axonal fasciculation	0.012279054389808362	0.012279054389808362	+1	ARHGAP35,EPHA3
ANIMAL ORGAN FORMATION%GOBP%GO:0048645	animal organ formation	0.012279054389808362	0.012279054389808362	+1	FGFR2,SOX17
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME DATABASE ID RELEASE 69%6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.012279054389808362	0.012279054389808362	+1	TP53,ATM
PI METABOLISM%REACTOME%R-HSA-1483255.5	PI Metabolism	0.012477121858158982	0.012477121858158982	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
TP53 REGULATES METABOLIC GENES%REACTOME DATABASE ID RELEASE 69%5628897	TP53 Regulates Metabolic Genes	0.012477121858158982	0.012477121858158982	+1	TP53,PTEN,AKT1,MTOR
REGULATION OF MORPHOGENESIS OF AN EPITHELIUM%GOBP%GO:1905330	regulation of morphogenesis of an epithelium	0.01247713902928043	0.01247713902928043	+1	PTEN,GATA3,SOX9,HGF,MTOR
SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 69%3899300	SUMOylation of transcription cofactors	0.012830119075274326	0.012830119075274326	+1	NPM1,EP300,SIN3A
DETERMINATION OF HEART LEFT/RIGHT ASYMMETRY%GOBP%GO:0061371	determination of heart left/right asymmetry	0.012830119075274326	0.012830119075274326	+1	NOTCH1,TGFBR2,SOX17
EMBRYONIC HEART TUBE MORPHOGENESIS%GOBP%GO:0003143	embryonic heart tube morphogenesis	0.012830119075274326	0.012830119075274326	+1	NOTCH1,TGFBR2,SOX17
REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA%GOBP%GO:0090199	regulation of release of cytochrome c from mitochondria	0.012830119075274326	0.012830119075274326	+1	TP53,AKT1,HGF
CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES%GOBP%GO:0034614	cellular response to reactive oxygen species	0.012960269041506428	0.012960269041506428	+1	EGFR,NFE2L2,AKT1,PDGFRA
GASTRULATION%GOBP%GO:0007369	gastrulation	0.012960269041506428	0.012960269041506428	+1	SETD2,FOXA2,SOX17,SMAD2
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.2	Transcriptional regulation of white adipocyte differentiation	0.012960269041506428	0.012960269041506428	+1	CEBPA,EP300,TBL1XR1,NCOR1
REGULATION OF CELL CYCLE G2/M PHASE TRANSITION%GOBP%GO:1902749	regulation of cell cycle G2/M phase transition	0.012977636093612821	0.012977636093612821	+1	TP53,NPM1,ATM,BRCA1,CCND1,PPP2R1A
STRIATED MUSCLE TISSUE DEVELOPMENT%GOBP%GO:0014706	striated muscle tissue development	0.013213964858651256	0.013213964858651256	+1	NOTCH1,WT1,PDGFRA,FGFR2,SMAD4
IL3%NETPATH%IL3	IL3	0.013490943806076846	0.013490943806076846	+1	PIK3R1,RB1,AKT1,PTPN11
CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 69%3371556	Cellular response to heat stress	0.013490943806076846	0.013490943806076846	+1	ATM,MTOR,EP300,ATR
REGIONALIZATION%GOBP%GO:0003002	regionalization	0.013606776759751076	0.013606776759751076	+1	TBX3,WT1,FGFR2,FOXA2,SMAD2
REGULATION OF HISTONE ACETYLATION%GOBP%GO:0035065	regulation of histone acetylation	0.013618641297180711	0.013618641297180711	+1	BRCA1,SMAD4,SIN3A
IL-2 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP49%HOMO SAPIENS	http://www.wikipathways.org/instance/WP49_r95132	0.013618641297180711	0.013618641297180711	+1	PIK3R1,AKT1,PTPN11
PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.1	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.013618641297180711	0.013618641297180711	+1	KRAS,NRAS,BRAF
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.1	Signaling by moderate kinase activity BRAF mutants	0.013618641297180711	0.013618641297180711	+1	KRAS,NRAS,BRAF
LIPID PHOSPHORYLATION%GOBP%GO:0046834	lipid phosphorylation	0.013618641297180711	0.013618641297180711	+1	PIK3CA,PIK3R1,PIK3CG
DNA-TEMPLATED TRANSCRIPTION, ELONGATION%GOBP%GO:0006354	DNA-templated transcription, elongation	0.013997332895351733	0.013997332895351733	+1	PBRM1,SETD2,CDK12,ERCC2
VIRAL ACUTE MYOCARDITIS%WIKIPATHWAYS_20190610%WP4298%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4298_r98082	0.013997332895351733	0.013997332895351733	+1	PIK3R1,AKT1,TLR4,CCND1
NEGATIVE REGULATION OF CENTROSOME CYCLE%GOBP%GO:0046606	negative regulation of centrosome cycle	0.0140608185566233	0.0140608185566233	+1	NPM1,BRCA1
NEGATIVE REGULATION OF KIDNEY DEVELOPMENT%GOBP%GO:0090185	negative regulation of kidney development	0.0140608185566233	0.0140608185566233	+1	GATA3,WT1
MITOTIC SISTER CHROMATID COHESION%GOBP%GO:0007064	mitotic sister chromatid cohesion	0.0140608185566233	0.0140608185566233	+1	RB1,SMC1A
NEGATIVE REGULATION OF PEPTIDYL-LYSINE ACETYLATION%GOBP%GO:2000757	negative regulation of peptidyl-lysine acetylation	0.0140608185566233	0.0140608185566233	+1	BRCA1,SIN3A
OLFACTORY LOBE DEVELOPMENT%GOBP%GO:0021988	olfactory lobe development	0.0140608185566233	0.0140608185566233	+1	ERBB4,LRRK2
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 69%113501	Inhibition of replication initiation of damaged DNA by RB1 E2F1	0.0140608185566233	0.0140608185566233	+1	RB1,PPP2R1A
OLFACTORY BULB DEVELOPMENT%GOBP%GO:0021772	olfactory bulb development	0.0140608185566233	0.0140608185566233	+1	ERBB4,LRRK2
RESPONSE TO UV-B%GOBP%GO:0010224	response to UV-B	0.0140608185566233	0.0140608185566233	+1	STK11,CDKN1A
REGULATION OF NUCLEAR CELL CYCLE DNA REPLICATION%GOBP%GO:0033262	regulation of nuclear cell cycle DNA replication	0.0140608185566233	0.0140608185566233	+1	ATRX,CHEK2
REGULATION OF RETINOIC ACID RECEPTOR SIGNALING PATHWAY%GOBP%GO:0048385	regulation of retinoic acid receptor signaling pathway	0.0140608185566233	0.0140608185566233	+1	ASXL1,EZH2
TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20190610%WP4211%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4211_r95891	0.0140608185566233	0.0140608185566233	+1	GATA3,CEBPA
BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY	BIOCARTA_CBL_PATHWAY	0.0140608185566233	0.0140608185566233	+1	EGFR,PDGFRA
INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031	Inflammation mediated by chemokine and cytokine signaling pathway	0.0140608185566233	0.0140608185566233	+1	PIK3CA,PTEN,KRAS,NRAS,AKT1,PIK3CG
HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20190610%WP186%HOMO SAPIENS	http://www.wikipathways.org/instance/WP186_r68935	0.0140608185566233	0.0140608185566233	+1	ATM,BRCA2
EMBRYONIC HEMOPOIESIS%GOBP%GO:0035162	embryonic hemopoiesis	0.0140608185566233	0.0140608185566233	+1	KIT,TGFBR2
METANEPHROS MORPHOGENESIS%GOBP%GO:0003338	metanephros morphogenesis	0.0140608185566233	0.0140608185566233	+1	SOX9,WT1
ERYTHROPOIETIN ACTIVATES RAS%REACTOME DATABASE ID RELEASE 69%9027284	Erythropoietin activates RAS	0.0140608185566233	0.0140608185566233	+1	KRAS,NRAS
BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY	BIOCARTA_P27_PATHWAY	0.0140608185566233	0.0140608185566233	+1	RB1,CDKN1B
DEVELOPMENTAL CELL GROWTH%GOBP%GO:0048588	developmental cell growth	0.01431588985127117	0.01431588985127117	+1	CTNNB1,SOX9,USP9X
FAS LIGAND (FASL) PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS (HSP) REGULATION%WIKIPATHWAYS_20190610%WP314%HOMO SAPIENS	http://www.wikipathways.org/instance/WP314_r94814	0.01431588985127117	0.01431588985127117	+1	RB1,MAP3K1,MAP2K4
INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.5	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.01431588985127117	0.01431588985127117	+1	PIK3CA,PIK3R1,PTPN11
NEGATIVE REGULATION OF ERK1 AND ERK2 CASCADE%GOBP%GO:0070373	negative regulation of ERK1 and ERK2 cascade	0.01431588985127117	0.01431588985127117	+1	PTEN,TLR4,SMAD4
REGULATION OF PHOSPHOLIPASE C ACTIVITY%GOBP%GO:1900274	regulation of phospholipase C activity	0.01431588985127117	0.01431588985127117	+1	EGFR,KIT,PDGFRA
RESPONSE TO METAL ION%GOBP%GO:0010038	response to metal ion	0.014352483504688814	0.014352483504688814	+1	EGFR,CDH1,AKT1,BRAF,CDKN1B,LRRK2
TELENCEPHALON DEVELOPMENT%GOBP%GO:0021537	telencephalon development	0.014923946061710701	0.014923946061710701	+1	PTEN,NF1,ERBB4,LRRK2
BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY	BIOCARTA_MAPK_PATHWAY	0.014923946061710701	0.014923946061710701	+1	MAP3K1,MAP2K4,CEBPA,BRAF
ANTERIOR/POSTERIOR PATTERN SPECIFICATION%GOBP%GO:0009952	anterior/posterior pattern specification	0.014923946061710701	0.014923946061710701	+1	TBX3,WT1,FOXA2,SMAD2
MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 69%912446	Meiotic recombination	0.014923946061710701	0.014923946061710701	+1	ATM,BRCA1,BRCA2,HIST1H2BD
HALLMARK_MITOTIC_SPINDLE%MSIGDB_C2%HALLMARK_MITOTIC_SPINDLE	HALLMARK_MITOTIC_SPINDLE	0.01499721146869608	0.01499721146869608	+1	APC,NF1,CRIPAK,BRCA2,SMC1A,SMC3
HALLMARK_ALLOGRAFT_REJECTION%MSIGDB_C2%HALLMARK_ALLOGRAFT_REJECTION	HALLMARK_ALLOGRAFT_REJECTION	0.01499721146869608	0.01499721146869608	+1	EGFR,CDKN2A,NPM1,AKT1,BRCA1,ACVR2A
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.4	Cell surface interactions at the vascular wall	0.01499721146869608	0.01499721146869608	+1	PIK3CA,KRAS,PIK3R1,NRAS,PTPN11
CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY	Ceramide signaling pathway	0.015136227897189252	0.015136227897189252	+1	MAP3K1,MAP2K4,AKT1
CELLULAR RESPONSE TO RETINOIC ACID%GOBP%GO:0071300	cellular response to retinoic acid	0.015136227897189252	0.015136227897189252	+1	EPHA3,SOX9,ATM
INTERLEUKIN-11 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP2332%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2332_r79525	0.015136227897189252	0.015136227897189252	+1	PIK3R1,AKT1,PTPN11
FSH%NETPATH%FSH	FSH	0.015136227897189252	0.015136227897189252	+1	EGFR,AKT1,MTOR
CELL GROWTH%GOBP%GO:0016049	cell growth	0.015136227897189252	0.015136227897189252	+1	CTNNB1,SOX9,USP9X
INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING	Integrin-linked kinase signaling	0.015136227897189252	0.015136227897189252	+1	CTNNB1,AKT1,CCND1
ESTABLISHMENT OF RNA LOCALIZATION%GOBP%GO:0051236	establishment of RNA localization	0.01538021343105153	0.01538021343105153	+1	NPM1,ATM,U2AF1,TGFBR2,ATR
NEGATIVE REGULATION OF DNA-BINDING TRANSCRIPTION FACTOR ACTIVITY%GOBP%GO:0043433	negative regulation of DNA-binding transcription factor activity	0.01582342225402533	0.01582342225402533	+1	CDKN2A,RB1,KEAP1,FOXA2,TAF1
REGULATION OF COLD-INDUCED THERMOGENESIS%GOBP%GO:0120161	regulation of cold-induced thermogenesis	0.01582342225402533	0.01582342225402533	+1	APC,RB1,NOTCH1,STK11,TLR4
PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY	PID_TCR_JNK_PATHWAY	0.01585487467747858	0.01585487467747858	+1	MAP3K1,MAP2K4
AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 69%5467340	AXIN missense mutants destabilize the destruction complex	0.01585487467747858	0.01585487467747858	+1	APC,PPP2R1A
TRUNCATED APC MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 69%4839744	truncated APC mutants destabilize the destruction complex	0.01585487467747858	0.01585487467747858	+1	APC,PPP2R1A
TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 69%5467348	Truncations of AMER1 destabilize the destruction complex	0.01585487467747858	0.01585487467747858	+1	APC,PPP2R1A
APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.1	APC truncation mutants have impaired AXIN binding	0.01585487467747858	0.01585487467747858	+1	APC,PPP2R1A
POSITIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS%GOBP%GO:1902884	positive regulation of response to oxidative stress	0.01585487467747858	0.01585487467747858	+1	FBXW7,TLR4
POSITIVE REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS%GOBP%GO:2001022	positive regulation of response to DNA damage stimulus	0.01585487467747858	0.01585487467747858	+1	EGFR,ATM,BRCA1,ATR
2-OXOGLUTARATE METABOLIC PROCESS%GOBP%GO:0006103	2-oxoglutarate metabolic process	0.01585487467747858	0.01585487467747858	+1	IDH1,IDH2
MITOTIC CELL CYCLE ARREST%GOBP%GO:0071850	mitotic cell cycle arrest	0.01585487467747858	0.01585487467747858	+1	CDKN1B,CDKN1A
ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY	Atypical NF-kappaB pathway	0.01585487467747858	0.01585487467747858	+1	PIK3CA,PIK3R1
BRANCHING INVOLVED IN BLOOD VESSEL MORPHOGENESIS%GOBP%GO:0001569	branching involved in blood vessel morphogenesis	0.01585487467747858	0.01585487467747858	+1	CTNNB1,TGFBR2
AMER1 MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-4839748.1	AMER1 mutants destabilize the destruction complex	0.01585487467747858	0.01585487467747858	+1	APC,PPP2R1A
RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 69%8941856	RUNX3 regulates NOTCH signaling	0.01585487467747858	0.01585487467747858	+1	NOTCH1,EP300
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.1	Regulation of TP53 Activity through Association with Co-factors	0.01585487467747858	0.01585487467747858	+1	TP53,AKT1
SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 69%5654688	SHC-mediated cascade:FGFR1	0.01585487467747858	0.01585487467747858	+1	KRAS,NRAS
APPENDAGE MORPHOGENESIS%GOBP%GO:0035107	appendage morphogenesis	0.01585487467747858	0.01585487467747858	+1	CTNNB1,TBX3,FGFR2
LIMB MORPHOGENESIS%GOBP%GO:0035108	limb morphogenesis	0.01585487467747858	0.01585487467747858	+1	CTNNB1,TBX3,FGFR2
RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY	RhoA signaling pathway	0.01585487467747858	0.01585487467747858	+1	PTEN,MAP2K4,CDKN1B
POSITIVE REGULATION OF ALPHA-BETA T CELL ACTIVATION%GOBP%GO:0046635	positive regulation of alpha-beta T cell activation	0.01585487467747858	0.01585487467747858	+1	RUNX1,TGFBR2,CBFB
PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY	PID_RHOA_PATHWAY	0.01585487467747858	0.01585487467747858	+1	PTEN,MAP2K4,CDKN1B
AXIN MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX, ACTIVATING WNT SIGNALING%REACTOME DATABASE ID RELEASE 69%4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	0.01585487467747858	0.01585487467747858	+1	APC,PPP2R1A
EMBRYONIC HEART TUBE DEVELOPMENT%GOBP%GO:0035050	embryonic heart tube development	0.01585487467747858	0.01585487467747858	+1	NOTCH1,TGFBR2,SOX17
JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY	JNK signaling in the CD4+ TCR pathway	0.01585487467747858	0.01585487467747858	+1	MAP3K1,MAP2K4
TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.1	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation	0.01642689361808725	0.01642689361808725	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
REGULATION OF CELL-MATRIX ADHESION%GOBP%GO:0001952	regulation of cell-matrix adhesion	0.01642689361808725	0.01642689361808725	+1	PTEN,NF1,CDKN2A,EPHA3
REGULATION OF ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0046637	regulation of alpha-beta T cell differentiation	0.016800507359456745	0.016800507359456745	+1	RUNX1,TGFBR2,CBFB
SIG_BCR_SIGNALING_PATHWAY%MSIGDB_C2%SIG_BCR_SIGNALING_PATHWAY	SIG_BCR_SIGNALING_PATHWAY	0.016800507359456745	0.016800507359456745	+1	PIK3CA,PIK3R1,AKT1
REGULATION OF PEPTIDYL-LYSINE ACETYLATION%GOBP%GO:2000756	regulation of peptidyl-lysine acetylation	0.016800507359456745	0.016800507359456745	+1	BRCA1,SMAD4,SIN3A
REGULATION OF MITOTIC METAPHASE/ANAPHASE TRANSITION%GOBP%GO:0030071	regulation of mitotic metaphase/anaphase transition	0.016800507359456745	0.016800507359456745	+1	APC,RB1,ATM
NEGATIVE REGULATION OF CELL MIGRATION%GOBP%GO:0030336	negative regulation of cell migration	0.01685292398551917	0.01685292398551917	+1	PTEN,NAV3,NF1,NOTCH1,CDH1,AKT1
REGULATION OF RESPONSE TO CYTOKINE STIMULUS%GOBP%GO:0060759	regulation of response to cytokine stimulus	0.016928360778351997	0.016928360778351997	+1	RUNX1,TLR4,CBFB,PTPN11,LIFR
TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 69%168181	Toll Like Receptor 7 8 (TLR7 8) Cascade	0.016959922863656177	0.016959922863656177	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
T-CELL ANTIGEN RECEPTOR (TCR)  SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP69%HOMO SAPIENS	http://www.wikipathways.org/instance/WP69_r103503	0.016959922863656177	0.016959922863656177	+1	PIK3R1,GATA3,AKT1,PTPN11
FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%R-HSA-201722.4	Formation of the beta-catenin:TCF transactivating complex	0.016959922863656177	0.016959922863656177	+1	CTNNB1,EP300,HIST1H2BD,AXIN2
CELLULAR RESPONSE TO FIBROBLAST GROWTH FACTOR STIMULUS%GOBP%GO:0044344	cellular response to fibroblast growth factor stimulus	0.016959922863656177	0.016959922863656177	+1	FGFR2,FGFR3,PTPN11,EGR3
MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 69%975155	MyD88 dependent cascade initiated on endosome	0.016959922863656177	0.016959922863656177	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
CORTICOTROPIN-RELEASING HORMONE SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP2355%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2355_r97622	0.0176146657831913	0.0176146657831913	+1	CTNNB1,AKT1,BRAF,TLR4
CELLULAR RESPONSE TO ALCOHOL%GOBP%GO:0097306	cellular response to alcohol	0.01769689321634413	0.01769689321634413	+1	CTNNB1,CDH1,BRCA1
REGULATION OF UBIQUITIN-PROTEIN TRANSFERASE ACTIVITY%GOBP%GO:0051438	regulation of ubiquitin-protein transferase activity	0.01769689321634413	0.01769689321634413	+1	PTEN,FBXW7,RPL5
PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY	PID_ILK_PATHWAY	0.01769689321634413	0.01769689321634413	+1	CTNNB1,AKT1,CCND1
REGULATION OF METAPHASE/ANAPHASE TRANSITION OF CELL CYCLE%GOBP%GO:1902099	regulation of metaphase/anaphase transition of cell cycle	0.01769689321634413	0.01769689321634413	+1	APC,RB1,ATM
BDNF%IOB%BDNF	BDNF	0.01769689321634413	0.01769689321634413	+1	CTNNB1,AKT1,MTOR
RESPONSE TO ACID CHEMICAL%GOBP%GO:0001101	response to acid chemical	0.017765063933691767	0.017765063933691767	+1	EPHA3,SOX9,ATM,MTOR,ASXL1
MUSCLE ORGAN DEVELOPMENT%GOBP%GO:0007517	muscle organ development	0.017765063933691767	0.017765063933691767	+1	NOTCH1,WT1,FGFR2,SMAD4,EGR3
NRF2 PATHWAY%WIKIPATHWAYS_20190610%WP2884%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2884_r103057	0.017765063933691767	0.017765063933691767	+1	KEAP1,NFE2L2,EPHA3,HGF,TGFBR2
BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY	BIOCARTA_HIF_PATHWAY	0.017800238199178614	0.017800238199178614	+1	VHL,EP300
POSITIVE REGULATION OF DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	0.017800238199178614	0.017800238199178614	+1	ATM,ATR
PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY	PID_ERBB_NETWORK_PATHWAY	0.017800238199178614	0.017800238199178614	+1	EGFR,ERBB4
METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20190610%WP2249%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2249_r102998	0.017800238199178614	0.017800238199178614	+1	TP53,PIK3R1
NEGATIVE REGULATION OF CD4-POSITIVE, ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	0.017800238199178614	0.017800238199178614	+1	RUNX1,CBFB
BRAIN MORPHOGENESIS%GOBP%GO:0048854	brain morphogenesis	0.017800238199178614	0.017800238199178614	+1	PTEN,NF1
ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK	ErbB receptor signaling network	0.017800238199178614	0.017800238199178614	+1	EGFR,ERBB4
NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT%GOBP%GO:0045992	negative regulation of embryonic development	0.017800238199178614	0.017800238199178614	+1	GATA3,CTNNB1
NEGATIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA%GOBP%GO:0090201	negative regulation of release of cytochrome c from mitochondria	0.017800238199178614	0.017800238199178614	+1	AKT1,HGF
NEGATIVE REGULATION OF TORC1 SIGNALING%GOBP%GO:1904262	negative regulation of TORC1 signaling	0.017800238199178614	0.017800238199178614	+1	STK11,ATM
REGULATION OF HISTONE H3-K9 METHYLATION%GOBP%GO:0051570	regulation of histone H3-K9 methylation	0.017800238199178614	0.017800238199178614	+1	ATRX,BRCA1
RESPONSE TO FIBROBLAST GROWTH FACTOR%GOBP%GO:0071774	response to fibroblast growth factor	0.018054315743827296	0.018054315743827296	+1	FGFR2,FGFR3,PTPN11,EGR3
REGULATION OF T CELL DIFFERENTIATION%GOBP%GO:0045580	regulation of T cell differentiation	0.018054315743827296	0.018054315743827296	+1	GATA3,RUNX1,TGFBR2,CBFB
POSITIVE REGULATION OF WNT SIGNALING PATHWAY%GOBP%GO:0030177	positive regulation of Wnt signaling pathway	0.018112299296924837	0.018112299296924837	+1	EGFR,LRRK2,FGFR2,TBL1XR1,AXIN2
POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY	Posttranslational regulation of adherens junction stability and dissassembly	0.01851034889809889	0.01851034889809889	+1	EGFR,CTNNB1,CDH1
SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.2	Signaling by NOTCH3	0.01851034889809889	0.01851034889809889	+1	EGFR,NOTCH1,EP300
POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT%GOBP%GO:0046824	positive regulation of nucleocytoplasmic transport	0.01851034889809889	0.01851034889809889	+1	TP53,PIK3R1,CDH1
PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY	PID_AJDISS_2PATHWAY	0.01851034889809889	0.01851034889809889	+1	EGFR,CTNNB1,CDH1
DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20190610%WP2848%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2848_r102217	0.01851034889809889	0.01851034889809889	+1	NOTCH1,HGF,KIT
TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.6	Toll-like Receptor Cascades	0.0185565296327724	0.0185565296327724	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A,PTPN11
TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 69%168188	Toll Like Receptor TLR6:TLR2 Cascade	0.018615665056993348	0.018615665056993348	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.1	Toll Like Receptor TLR1:TLR2 Cascade	0.018615665056993348	0.018615665056993348	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-166058.3	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.018615665056993348	0.018615665056993348	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.1	Toll Like Receptor 2 (TLR2) Cascade	0.018615665056993348	0.018615665056993348	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 69%168138	Toll Like Receptor 9 (TLR9) Cascade	0.019306954526312106	0.019306954526312106	+1	MAP3K1,MAP2K4,TLR4,PPP2R1A
IL-3 SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP286%HOMO SAPIENS	http://www.wikipathways.org/instance/WP286_r78583	0.019508500452783	0.019508500452783	+1	PIK3R1,AKT1,PTPN11
POSITIVE REGULATION OF TELOMERE MAINTENANCE%GOBP%GO:0032206	positive regulation of telomere maintenance	0.019508500452783	0.019508500452783	+1	ATM,ATRX,ATR
REGULATION OF JNK CASCADE%GOBP%GO:0046328	regulation of JNK cascade	0.01951419317115734	0.01951419317115734	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
REGULATION OF CELL-CELL ADHESION MEDIATED BY CADHERIN%GOBP%GO:2000047	regulation of cell-cell adhesion mediated by cadherin	0.019751828842289928	0.019751828842289928	+1	FOXA1,FOXA2
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.2	Signaling by cytosolic FGFR1 fusion mutants	0.019751828842289928	0.019751828842289928	+1	PIK3CA,PIK3R1
VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 69%5218921	VEGFR2 mediated cell proliferation	0.019751828842289928	0.019751828842289928	+1	KRAS,NRAS
REGULATION OF OXIDATIVE STRESS-INDUCED NEURON DEATH%GOBP%GO:1903203	regulation of oxidative stress-induced neuron death	0.019751828842289928	0.019751828842289928	+1	FBXW7,TLR4
NEGATIVE REGULATION OF JAK-STAT CASCADE%GOBP%GO:0046426	negative regulation of JAK-STAT cascade	0.019751828842289928	0.019751828842289928	+1	VHL,PPP2R1A
TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 69%937061	TRIF(TICAM1)-mediated TLR4 signaling	0.019751828842289928	0.019751828842289928	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION%GOBP%GO:1902107	positive regulation of leukocyte differentiation	0.019751828842289928	0.019751828842289928	+1	GATA3,RUNX1,TGFBR2,CBFB
REGULATION OF DNA BIOSYNTHETIC PROCESS%GOBP%GO:2000278	regulation of DNA biosynthetic process	0.019751828842289928	0.019751828842289928	+1	TP53,ATM,HGF,ATR
NEGATIVE REGULATION OF ANOIKIS%GOBP%GO:2000811	negative regulation of anoikis	0.019751828842289928	0.019751828842289928	+1	PIK3CA,NOTCH1
MAINTENANCE OF GASTROINTESTINAL EPITHELIUM%GOBP%GO:0030277	maintenance of gastrointestinal epithelium	0.019751828842289928	0.019751828842289928	+1	SOX9,TLR4
POSITIVE REGULATION OF TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER%GOBP%GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	0.019751828842289928	0.019751828842289928	+1	TP53,TAF1
REGULATION OF FATTY ACID TRANSPORT%GOBP%GO:2000191	regulation of fatty acid transport	0.019751828842289928	0.019751828842289928	+1	AKT1,NCOR1
PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.2	Platelet sensitization by LDL	0.019751828842289928	0.019751828842289928	+1	PPP2R1A,PTPN11
MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.2	MyD88-independent TLR4 cascade	0.019751828842289928	0.019751828842289928	+1	MAP2K4,TLR4,PPP2R1A,PTPN11
SHC-MEDIATED CASCADE:FGFR4%REACTOME%R-HSA-5654719.2	SHC-mediated cascade:FGFR4	0.019751828842289928	0.019751828842289928	+1	KRAS,NRAS
NUCLEOSOME POSITIONING%GOBP%GO:0016584	nucleosome positioning	0.019751828842289928	0.019751828842289928	+1	CTCF,HIST1H1C
HETEROCHROMATIN ORGANIZATION%GOBP%GO:0070828	heterochromatin organization	0.019751828842289928	0.019751828842289928	+1	CDKN2A,MECOM
FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 69%9614657	FOXO-mediated transcription of cell death genes	0.019751828842289928	0.019751828842289928	+1	STK11,EP300
HAIR CELL DIFFERENTIATION%GOBP%GO:0035315	hair cell differentiation	0.019751828842289928	0.019751828842289928	+1	CTNNB1,ERCC2
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 69%936964	Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon	0.019751828842289928	0.019751828842289928	+1	TLR4,PTPN11
REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 69%210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.019751828842289928	0.019751828842289928	+1	NOTCH1,EP300
NEGATIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING%GOBP%GO:2000678	negative regulation of transcription regulatory region DNA binding	0.019751828842289928	0.019751828842289928	+1	TAF1,SIN3A
REGULATION OF CELL-SUBSTRATE ADHESION%GOBP%GO:0010810	regulation of cell-substrate adhesion	0.019769915975253786	0.019769915975253786	+1	PTEN,NF1,CDKN2A,NOTCH1,EPHA3
INNER EAR DEVELOPMENT%GOBP%GO:0048839	inner ear development	0.020256078948797496	0.020256078948797496	+1	SOX9,FGFR2,PTPN11
ENDOTHELIAL CELL MIGRATION%GOBP%GO:0043542	endothelial cell migration	0.020256078948797496	0.020256078948797496	+1	PIK3CA,AKT1,EGR3
HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.3	HDMs demethylate histones	0.020256078948797496	0.020256078948797496	+1	KDM6A,KDM5C,ARID5B
EPITHELIAL TUBE FORMATION%GOBP%GO:0072175	epithelial tube formation	0.020256078948797496	0.020256078948797496	+1	GATA3,SOX9,FGFR2
CARDIAC MUSCLE TISSUE MORPHOGENESIS%GOBP%GO:0055008	cardiac muscle tissue morphogenesis	0.020256078948797496	0.020256078948797496	+1	NOTCH1,FGFR2,SMAD4
NEGATIVE REGULATION OF CHROMATIN ORGANIZATION%GOBP%GO:1905268	negative regulation of chromatin organization	0.020256078948797496	0.020256078948797496	+1	BRCA1,HIST1H1C,SIN3A
NEGATIVE REGULATION OF GLIOGENESIS%GOBP%GO:0014014	negative regulation of gliogenesis	0.02092908911660815	0.02092908911660815	+1	NF1,NOTCH1
SQUAMOUS BASAL EPITHELIAL STEM CELL DIFFERENTIATION INVOLVED IN PROSTATE GLAND ACINUS DEVELOPMENT%GOBP%GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	0.02092908911660815	0.02092908911660815	+1	FGFR2
REGULATION OF CELL PROLIFERATION INVOLVED IN TISSUE HOMEOSTASIS%GOBP%GO:0060784	regulation of cell proliferation involved in tissue homeostasis	0.02092908911660815	0.02092908911660815	+1	SOX9
PROSTATE EPITHELIAL CORD ARBORIZATION INVOLVED IN PROSTATE GLANDULAR ACINUS MORPHOGENESIS%GOBP%GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	0.02092908911660815	0.02092908911660815	+1	FGFR2
NEPHRON EPITHELIUM DEVELOPMENT%GOBP%GO:0072009	nephron epithelium development	0.02092908911660815	0.02092908911660815	+1	GATA3,SOX9,WT1
PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.1	Processing of DNA double-strand break ends	0.02092908911660815	0.02092908911660815	+1	ATM,BRCA1,ATR,HIST1H2BD
SIGNAL TRANSDUCTION INVOLVED IN INTRA-S DNA DAMAGE CHECKPOINT%GOBP%GO:0072428	signal transduction involved in intra-S DNA damage checkpoint	0.02092908911660815	0.02092908911660815	+1	CHEK2
REGULATION OF TELOMERIC RNA TRANSCRIPTION FROM RNA POL II PROMOTER%GOBP%GO:1901580	regulation of telomeric RNA transcription from RNA pol II promoter	0.02092908911660815	0.02092908911660815	+1	ATRX
REGULATION OF PROTEIN PROCESSING INVOLVED IN PROTEIN TARGETING TO MITOCHONDRION%GOBP%GO:1903216	regulation of protein processing involved in protein targeting to mitochondrion	0.02092908911660815	0.02092908911660815	+1	LRRK2
REGULATION OF MRNA STABILITY INVOLVED IN CELLULAR RESPONSE TO UV%GOBP%GO:1902629	regulation of mRNA stability involved in cellular response to UV	0.02092908911660815	0.02092908911660815	+1	NPM1
POSITIVE REGULATION OF CELL PROLIFERATION INVOLVED IN HEART VALVE MORPHOGENESIS%GOBP%GO:0003251	positive regulation of cell proliferation involved in heart valve morphogenesis	0.02092908911660815	0.02092908911660815	+1	SMAD4
NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER BY GLUCOSE%GOBP%GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	0.02092908911660815	0.02092908911660815	+1	FOXA2
REGULATION OF CENTROSOME CYCLE%GOBP%GO:0046605	regulation of centrosome cycle	0.02092908911660815	0.02092908911660815	+1	CTNNB1,NPM1,BRCA1
HAIR FOLLICLE DEVELOPMENT%GOBP%GO:0001942	hair follicle development	0.02092908911660815	0.02092908911660815	+1	SOX9,FGFR2
REGULATION OF TRANSCRIPTION INVOLVED IN PRIMARY GERM LAYER CELL FATE COMMITMENT%GOBP%GO:0060796	regulation of transcription involved in primary germ layer cell fate commitment	0.02092908911660815	0.02092908911660815	+1	SOX17
NEGATIVE REGULATION OF PROTEIN KINASE ACTIVITY BY PROTEIN PHOSPHORYLATION%GOBP%GO:0100002	negative regulation of protein kinase activity by protein phosphorylation	0.02092908911660815	0.02092908911660815	+1	AKT1
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN ORBITOFRONTAL CORTEX DEVELOPMENT%GOBP%GO:0035607	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	0.02092908911660815	0.02092908911660815	+1	FGFR2
CANONICAL WNT SIGNALING PATHWAY INVOLVED IN METANEPHRIC KIDNEY DEVELOPMENT%GOBP%GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	0.02092908911660815	0.02092908911660815	+1	GATA3
CANONICAL WNT SIGNALING PATHWAY INVOLVED IN NEGATIVE REGULATION OF APOPTOTIC PROCESS%GOBP%GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	0.02092908911660815	0.02092908911660815	+1	CTNNB1
NEGATIVE REGULATION OF CELL PROLIFERATION INVOLVED IN MESONEPHROS DEVELOPMENT%GOBP%GO:2000607	negative regulation of cell proliferation involved in mesonephros development	0.02092908911660815	0.02092908911660815	+1	GATA3
NEGATIVE REGULATION OF THIOREDOXIN PEROXIDASE ACTIVITY BY PEPTIDYL-THREONINE PHOSPHORYLATION%GOBP%GO:1903125	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation	0.02092908911660815	0.02092908911660815	+1	LRRK2
NEGATIVE REGULATION OF PROTEIN PROCESSING INVOLVED IN PROTEIN TARGETING TO MITOCHONDRION%GOBP%GO:1903217	negative regulation of protein processing involved in protein targeting to mitochondrion	0.02092908911660815	0.02092908911660815	+1	LRRK2
REGULATION OF BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS BY MESENCHYMAL-EPITHELIAL SIGNALING%GOBP%GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	0.02092908911660815	0.02092908911660815	+1	HGF
POSITIVE REGULATION OF TELOMERIC RNA TRANSCRIPTION FROM RNA POL II PROMOTER%GOBP%GO:1901582	positive regulation of telomeric RNA transcription from RNA pol II promoter	0.02092908911660815	0.02092908911660815	+1	ATRX
NEGATIVE REGULATION OF TELOMERIC RNA TRANSCRIPTION FROM RNA POL II PROMOTER%GOBP%GO:1901581	negative regulation of telomeric RNA transcription from RNA pol II promoter	0.02092908911660815	0.02092908911660815	+1	ATRX
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN HEMOPOIESIS%GOBP%GO:0035603	fibroblast growth factor receptor signaling pathway involved in hemopoiesis	0.02092908911660815	0.02092908911660815	+1	FGFR2
APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 69%5467333	APC truncation mutants are not K63 polyubiquitinated	0.02092908911660815	0.02092908911660815	+1	APC
BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY	BIOCARTA_PML_PATHWAY	0.02092908911660815	0.02092908911660815	+1	TP53,RB1
MORPHOGENESIS OF EMBRYONIC EPITHELIUM%GOBP%GO:0016331	morphogenesis of embryonic epithelium	0.02092908911660815	0.02092908911660815	+1	GATA3,SOX9,FGFR2
SIGNAL TRANSDUCTION INVOLVED IN MITOTIC G2 DNA DAMAGE CHECKPOINT%GOBP%GO:0072434	signal transduction involved in mitotic G2 DNA damage checkpoint	0.02092908911660815	0.02092908911660815	+1	ATM
SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-HSA-5654699.1	SHC-mediated cascade:FGFR2	0.02092908911660815	0.02092908911660815	+1	KRAS,NRAS
LEPTIN INSULIN OVERLAP%WIKIPATHWAYS_20190610%WP3935%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3935_r90771	0.02092908911660815	0.02092908911660815	+1	AKT1,PIK3CG
PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY	PID_NFKAPPAB_ATYPICAL_PATHWAY	0.02092908911660815	0.02092908911660815	+1	PIK3CA,PIK3R1
POSITIVE REGULATION OF TOLERANCE INDUCTION TO SELF ANTIGEN%GOBP%GO:0002651	positive regulation of tolerance induction to self antigen	0.02092908911660815	0.02092908911660815	+1	TGFBR2
SUPERIOR ENDOCARDIAL CUSHION MORPHOGENESIS%GOBP%GO:1905316	superior endocardial cushion morphogenesis	0.02092908911660815	0.02092908911660815	+1	TGFBR2
CARDIAC RIGHT ATRIUM MORPHOGENESIS%GOBP%GO:0003213	cardiac right atrium morphogenesis	0.02092908911660815	0.02092908911660815	+1	NOTCH1
PROSTATE GLANDULAR ACINUS MORPHOGENESIS%GOBP%GO:0060526	prostate glandular acinus morphogenesis	0.02092908911660815	0.02092908911660815	+1	FGFR2
PRIMARY SEX DETERMINATION, GERM-LINE%GOBP%GO:0007542	primary sex determination, germ-line	0.02092908911660815	0.02092908911660815	+1	SOX9
MALE GERM-LINE SEX DETERMINATION%GOBP%GO:0019100	male germ-line sex determination	0.02092908911660815	0.02092908911660815	+1	SOX9
REGULATION OF INVADOPODIUM DISASSEMBLY%GOBP%GO:1905927	regulation of invadopodium disassembly	0.02092908911660815	0.02092908911660815	+1	NAV3
INFERIOR ENDOCARDIAL CUSHION MORPHOGENESIS%GOBP%GO:1905317	inferior endocardial cushion morphogenesis	0.02092908911660815	0.02092908911660815	+1	TGFBR2
VENOUS ENDOTHELIAL CELL DIFFERENTIATION%GOBP%GO:0060843	venous endothelial cell differentiation	0.02092908911660815	0.02092908911660815	+1	NOTCH1
PROSTATE GLANDULAR ACINUS DEVELOPMENT%GOBP%GO:0060525	prostate glandular acinus development	0.02092908911660815	0.02092908911660815	+1	FGFR2
MAMMARY GLAND BUD FORMATION%GOBP%GO:0060615	mammary gland bud formation	0.02092908911660815	0.02092908911660815	+1	FGFR2
VISCERAL SEROUS PERICARDIUM DEVELOPMENT%GOBP%GO:0061032	visceral serous pericardium development	0.02092908911660815	0.02092908911660815	+1	WT1
SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.1	Signaling by FGFR2 amplification mutants	0.02092908911660815	0.02092908911660815	+1	FGFR2
REGULATION OF DETECTION OF GLUCOSE%GOBP%GO:2000970	regulation of detection of glucose	0.02092908911660815	0.02092908911660815	+1	FOXA2
NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY%GOBP%GO:0090090	negative regulation of canonical Wnt signaling pathway	0.02092908911660815	0.02092908911660815	+1	APC,STK11,SOX9,SOX17,AXIN2
MITOTIC RECOMBINATION-DEPENDENT REPLICATION FORK PROCESSING%GOBP%GO:1990426	mitotic recombination-dependent replication fork processing	0.02092908911660815	0.02092908911660815	+1	BRCA2
REGULATION OF MOLECULAR FUNCTION, EPIGENETIC%GOBP%GO:0040030	regulation of molecular function, epigenetic	0.02092908911660815	0.02092908911660815	+1	CTCF
REGULATION OF HISTONE H4-K20 METHYLATION%GOBP%GO:0070510	regulation of histone H4-K20 methylation	0.02092908911660815	0.02092908911660815	+1	BRCA1
NEGATIVE REGULATION OF PEROXIDASE ACTIVITY%GOBP%GO:2000469	negative regulation of peroxidase activity	0.02092908911660815	0.02092908911660815	+1	LRRK2
PROSTATE EPITHELIAL CORD ELONGATION%GOBP%GO:0060523	prostate epithelial cord elongation	0.02092908911660815	0.02092908911660815	+1	FGFR2
PRIMARY PROSTATIC BUD ELONGATION%GOBP%GO:0060516	primary prostatic bud elongation	0.02092908911660815	0.02092908911660815	+1	SOX9
MAMMARY GLAND BUD MORPHOGENESIS%GOBP%GO:0060648	mammary gland bud morphogenesis	0.02092908911660815	0.02092908911660815	+1	FGFR2
ORBITOFRONTAL CORTEX DEVELOPMENT%GOBP%GO:0021769	orbitofrontal cortex development	0.02092908911660815	0.02092908911660815	+1	FGFR2
CHONDROCYTE HYPERTROPHY%GOBP%GO:0003415	chondrocyte hypertrophy	0.02092908911660815	0.02092908911660815	+1	SOX9
PEPTIDYL-LYSINE PROPIONYLATION%GOBP%GO:0061921	peptidyl-lysine propionylation	0.02092908911660815	0.02092908911660815	+1	EP300
PEPTIDYL-LYSINE BUTYRYLATION%GOBP%GO:0140067	peptidyl-lysine butyrylation	0.02092908911660815	0.02092908911660815	+1	EP300
PEPTIDYL-LYSINE CROTONYLATION%GOBP%GO:0140066	peptidyl-lysine crotonylation	0.02092908911660815	0.02092908911660815	+1	EP300
MELANOCYTE ADHESION%GOBP%GO:0097326	melanocyte adhesion	0.02092908911660815	0.02092908911660815	+1	KIT
FOLLICLE-STIMULATING HORMONE SECRETION%GOBP%GO:0046884	follicle-stimulating hormone secretion	0.02092908911660815	0.02092908911660815	+1	TBX3
URETERIC BUD FORMATION%GOBP%GO:0060676	ureteric bud formation	0.02092908911660815	0.02092908911660815	+1	GATA3
CARDIOGENIC PLATE MORPHOGENESIS%GOBP%GO:0003142	cardiogenic plate morphogenesis	0.02092908911660815	0.02092908911660815	+1	SOX17
CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN CELL-CELL SIGNALING%GOBP%GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	0.02092908911660815	0.02092908911660815	+1	PTEN,APC,GATA3,CTNNB1,AKT1,LRRK2
MESENCHYMAL-EPITHELIAL CELL SIGNALING%GOBP%GO:0060638	mesenchymal-epithelial cell signaling	0.02092908911660815	0.02092908911660815	+1	HGF
LUNG LOBE MORPHOGENESIS%GOBP%GO:0060463	lung lobe morphogenesis	0.02092908911660815	0.02092908911660815	+1	FGFR2
FOREBRAIN ASTROCYTE DIFFERENTIATION%GOBP%GO:0021896	forebrain astrocyte differentiation	0.02092908911660815	0.02092908911660815	+1	NF1
LUTEINIZING HORMONE SECRETION%GOBP%GO:0032275	luteinizing hormone secretion	0.02092908911660815	0.02092908911660815	+1	TBX3
MAST CELL PROLIFERATION%GOBP%GO:0070662	mast cell proliferation	0.02092908911660815	0.02092908911660815	+1	KIT
LUNG LOBE DEVELOPMENT%GOBP%GO:0060462	lung lobe development	0.02092908911660815	0.02092908911660815	+1	FGFR2
WNT SIGNALOSOME ASSEMBLY%GOBP%GO:1904887	Wnt signalosome assembly	0.02092908911660815	0.02092908911660815	+1	LRRK2
GERM-LINE SEX DETERMINATION%GOBP%GO:0018992	germ-line sex determination	0.02092908911660815	0.02092908911660815	+1	SOX9
FOREBRAIN ASTROCYTE DEVELOPMENT%GOBP%GO:0021897	forebrain astrocyte development	0.02092908911660815	0.02092908911660815	+1	NF1
HISTONE H3-K36 TRIMETHYLATION%GOBP%GO:0097198	histone H3-K36 trimethylation	0.02092908911660815	0.02092908911660815	+1	SETD2
REGULATION OF CARDIAC MYOFIBRIL ASSEMBLY%GOBP%GO:1905304	regulation of cardiac myofibril assembly	0.02092908911660815	0.02092908911660815	+1	SMAD4
NEGATIVE REGULATION OF METANEPHRIC GLOMERULAR MESANGIAL CELL PROLIFERATION%GOBP%GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation	0.02092908911660815	0.02092908911660815	+1	WT1
MORPHOGENESIS OF AN EPITHELIAL BUD%GOBP%GO:0060572	morphogenesis of an epithelial bud	0.02092908911660815	0.02092908911660815	+1	FGFR2
DNA RECOMBINATION%GOBP%GO:0006310	DNA recombination	0.02092908911660815	0.02092908911660815	+1	ATM,BRCA1,POLQ,BRCA2,RAD21
NEGATIVE REGULATION OF EPITHELIAL TUBE FORMATION%GOBP%GO:1905277	negative regulation of epithelial tube formation	0.02092908911660815	0.02092908911660815	+1	GATA3
REGULATION OF TOLERANCE INDUCTION TO SELF ANTIGEN%GOBP%GO:0002649	regulation of tolerance induction to self antigen	0.02092908911660815	0.02092908911660815	+1	TGFBR2
REGULATION OF EIF2 ALPHA PHOSPHORYLATION BY DSRNA%GOBP%GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA	0.02092908911660815	0.02092908911660815	+1	NPM1
WNT SIGNALING PATHWAY INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:0061289	Wnt signaling pathway involved in kidney development	0.02092908911660815	0.02092908911660815	+1	GATA3
REGULATION OF RNA-DIRECTED 5'-3' RNA POLYMERASE ACTIVITY%GOBP%GO:1900259	regulation of RNA-directed 5'-3' RNA polymerase activity	0.02092908911660815	0.02092908911660815	+1	EIF4A2
POSITIVE REGULATION OF NK T CELL DIFFERENTIATION%GOBP%GO:0051138	positive regulation of NK T cell differentiation	0.02092908911660815	0.02092908911660815	+1	TGFBR2
FIBROBLAST GROWTH FACTOR RECEPTOR APOPTOTIC SIGNALING PATHWAY%GOBP%GO:1902178	fibroblast growth factor receptor apoptotic signaling pathway	0.02092908911660815	0.02092908911660815	+1	FGFR3
CELL PROLIFERATION INVOLVED IN ENDOCARDIAL CUSHION MORPHOGENESIS%GOBP%GO:1905315	cell proliferation involved in endocardial cushion morphogenesis	0.02092908911660815	0.02092908911660815	+1	TGFBR2
MITOTIC DNA REPLICATION MAINTENANCE OF FIDELITY%GOBP%GO:1990505	mitotic DNA replication maintenance of fidelity	0.02092908911660815	0.02092908911660815	+1	BRCA2
MESENCHYMAL CELL DIFFERENTIATION INVOLVED IN LUNG DEVELOPMENT%GOBP%GO:0060915	mesenchymal cell differentiation involved in lung development	0.02092908911660815	0.02092908911660815	+1	FGFR2
REGULATION OF OLIGODENDROCYTE DIFFERENTIATION%GOBP%GO:0048713	regulation of oligodendrocyte differentiation	0.02092908911660815	0.02092908911660815	+1	NF1,NOTCH1
MESENCHYMAL CELL PROLIFERATION INVOLVED IN LUNG DEVELOPMENT%GOBP%GO:0060916	mesenchymal cell proliferation involved in lung development	0.02092908911660815	0.02092908911660815	+1	FGFR2
PTEN LOSS OF FUNCTION IN CANCER%REACTOME DATABASE ID RELEASE 69%5674404	PTEN Loss of Function in Cancer	0.02092908911660815	0.02092908911660815	+1	PTEN
ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 69%2978092	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	0.02092908911660815	0.02092908911660815	+1	IDH1
NEGATIVE REGULATION OF RNA-DIRECTED 5'-3' RNA POLYMERASE ACTIVITY%GOBP%GO:1900260	negative regulation of RNA-directed 5'-3' RNA polymerase activity	0.02092908911660815	0.02092908911660815	+1	EIF4A2
REGULATION OF CELL PROLIFERATION INVOLVED IN MESONEPHROS DEVELOPMENT%GOBP%GO:2000606	regulation of cell proliferation involved in mesonephros development	0.02092908911660815	0.02092908911660815	+1	GATA3
EPITHELIAL CELL PROLIFERATION INVOLVED IN PROSTATE GLAND DEVELOPMENT%GOBP%GO:0060767	epithelial cell proliferation involved in prostate gland development	0.02092908911660815	0.02092908911660815	+1	SOX9
EPITHELIAL CELL PROLIFERATION INVOLVED IN PROSTATIC BUD ELONGATION%GOBP%GO:0060517	epithelial cell proliferation involved in prostatic bud elongation	0.02092908911660815	0.02092908911660815	+1	SOX9
BRANCH ELONGATION INVOLVED IN SALIVARY GLAND MORPHOGENESIS%GOBP%GO:0060667	branch elongation involved in salivary gland morphogenesis	0.02092908911660815	0.02092908911660815	+1	FGFR2
NEGATIVE REGULATION OF TRANSCRIPTION BY GLUCOSE%GOBP%GO:0061986	negative regulation of transcription by glucose	0.02092908911660815	0.02092908911660815	+1	FOXA2
NEGATIVE REGULATION OF THIOREDOXIN PEROXIDASE ACTIVITY%GOBP%GO:1903124	negative regulation of thioredoxin peroxidase activity	0.02092908911660815	0.02092908911660815	+1	LRRK2
ACTIVATION-INDUCED CELL DEATH OF T CELLS%GOBP%GO:0006924	activation-induced cell death of T cells	0.02092908911660815	0.02092908911660815	+1	AKT1
LATERAL SPROUTING FROM AN EPITHELIUM%GOBP%GO:0060601	lateral sprouting from an epithelium	0.02092908911660815	0.02092908911660815	+1	FGFR2
NEGATIVE REGULATION OF KERATINOCYTE MIGRATION%GOBP%GO:0051548	negative regulation of keratinocyte migration	0.02092908911660815	0.02092908911660815	+1	PTEN
REGULATION OF THIOREDOXIN PEROXIDASE ACTIVITY%GOBP%GO:1903123	regulation of thioredoxin peroxidase activity	0.02092908911660815	0.02092908911660815	+1	LRRK2
POSITIVE REGULATION OF INVADOPODIUM DISASSEMBLY%GOBP%GO:1905929	positive regulation of invadopodium disassembly	0.02092908911660815	0.02092908911660815	+1	NAV3
T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME DATABASE ID RELEASE 69%2033515	t(4;14) translocations of FGFR3	0.02092908911660815	0.02092908911660815	+1	FGFR3
SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 69%8853333	Signaling by FGFR2 fusions	0.02092908911660815	0.02092908911660815	+1	FGFR2
PLATELET-DERIVED GROWTH FACTOR RECEPTOR-ALPHA SIGNALING PATHWAY%GOBP%GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway	0.02092908911660815	0.02092908911660815	+1	PDGFRA
CELL-CELL SIGNALING INVOLVED IN METANEPHROS DEVELOPMENT%GOBP%GO:0072204	cell-cell signaling involved in metanephros development	0.02092908911660815	0.02092908911660815	+1	GATA3
NEGATIVE REGULATION OF CARDIAC MYOFIBRIL ASSEMBLY%GOBP%GO:1905305	negative regulation of cardiac myofibril assembly	0.02092908911660815	0.02092908911660815	+1	SMAD4
NEGATIVE REGULATION OF DETECTION OF GLUCOSE%GOBP%GO:2000971	negative regulation of detection of glucose	0.02092908911660815	0.02092908911660815	+1	FOXA2
TREHALOSE METABOLISM IN RESPONSE TO STRESS%GOBP%GO:0070413	trehalose metabolism in response to stress	0.02092908911660815	0.02092908911660815	+1	BRAF
BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS%GOBP%GO:0060445	branching involved in salivary gland morphogenesis	0.02092908911660815	0.02092908911660815	+1	FGFR2
NEGATIVE REGULATION OF METANEPHRIC GLOMERULUS DEVELOPMENT%GOBP%GO:0072299	negative regulation of metanephric glomerulus development	0.02092908911660815	0.02092908911660815	+1	WT1
BUD ELONGATION INVOLVED IN LUNG BRANCHING%GOBP%GO:0060449	bud elongation involved in lung branching	0.02092908911660815	0.02092908911660815	+1	FGFR2
POSITIVE REGULATION OF HISTONE H4-K20 METHYLATION%GOBP%GO:0070512	positive regulation of histone H4-K20 methylation	0.02092908911660815	0.02092908911660815	+1	BRCA1
NEGATIVE REGULATION OF SYNAPTIC VESICLE CLUSTERING%GOBP%GO:2000808	negative regulation of synaptic vesicle clustering	0.02092908911660815	0.02092908911660815	+1	PTEN
CELL-CELL SIGNALING INVOLVED IN KIDNEY DEVELOPMENT%GOBP%GO:0060995	cell-cell signaling involved in kidney development	0.02092908911660815	0.02092908911660815	+1	GATA3
BRANCHING INVOLVED IN LABYRINTHINE LAYER MORPHOGENESIS%GOBP%GO:0060670	branching involved in labyrinthine layer morphogenesis	0.02092908911660815	0.02092908911660815	+1	FGFR2
NEGATIVE REGULATION OF HISTONE H3-K27 ACETYLATION%GOBP%GO:1901675	negative regulation of histone H3-K27 acetylation	0.02092908911660815	0.02092908911660815	+1	SIN3A
POSITIVE REGULATION OF MITOTIC RECOMBINATION%GOBP%GO:0045951	positive regulation of mitotic recombination	0.02092908911660815	0.02092908911660815	+1	ERCC2
CELL CYCLE DNA REPLICATION MAINTENANCE OF FIDELITY%GOBP%GO:1902298	cell cycle DNA replication maintenance of fidelity	0.02092908911660815	0.02092908911660815	+1	BRCA2
NADPH REGENERATION%REACTOME%R-HSA-389542.2	NADPH regeneration	0.02092908911660815	0.02092908911660815	+1	IDH1
NEGATIVE REGULATION OF PROTEIN ACETYLATION%GOBP%GO:1901984	negative regulation of protein acetylation	0.02092908911660815	0.02092908911660815	+1	BRCA1,SIN3A
NEGATIVE REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN URETERIC BUD FORMATION%GOBP%GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.02092908911660815	0.02092908911660815	+1	GATA3
REGULATION OF GLIAL CELL-DERIVED NEUROTROPHIC FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN URETERIC BUD FORMATION%GOBP%GO:2000733	regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.02092908911660815	0.02092908911660815	+1	GATA3
POSITIVE REGULATION OF TRANSCRIPTION OF NOTCH RECEPTOR TARGET%GOBP%GO:0007221	positive regulation of transcription of Notch receptor target	0.02092908911660815	0.02092908911660815	+1	NOTCH1,EP300
NEGATIVE REGULATION OF CELL-SUBSTRATE ADHESION%GOBP%GO:0010812	negative regulation of cell-substrate adhesion	0.02092908911660815	0.02092908911660815	+1	PTEN,CDKN2A,NOTCH1
CANONICAL WNT SIGNALING PATHWAY INVOLVED IN POSITIVE REGULATION OF CARDIAC OUTFLOW TRACT CELL PROLIFERATION%GOBP%GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	0.02092908911660815	0.02092908911660815	+1	CTNNB1
REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN URETERIC BUD FORMATION%GOBP%GO:2000702	regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	0.02092908911660815	0.02092908911660815	+1	GATA3
PROTEIN LOCALIZATION TO CHROMOSOME, CENTROMERIC REGION%GOBP%GO:0071459	protein localization to chromosome, centromeric region	0.02092908911660815	0.02092908911660815	+1	RB1,CTCF
REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 69%912631	Regulation of signaling by CBL	0.02092908911660815	0.02092908911660815	+1	PIK3CA,PIK3R1
POSITIVE REGULATION OF MACROPHAGE ACTIVATION%GOBP%GO:0043032	positive regulation of macrophage activation	0.02092908911660815	0.02092908911660815	+1	CEBPA,TLR4
REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY%GOBP%GO:2000810	regulation of bicellular tight junction assembly	0.02092908911660815	0.02092908911660815	+1	RUNX1,CBFB
REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN DEFINITIVE ENDODERMAL CELL FATE SPECIFICATION%GOBP%GO:0060807	regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification	0.02092908911660815	0.02092908911660815	+1	SOX17
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.2	Transcriptional activation of mitochondrial biogenesis	0.02092908911660815	0.02092908911660815	+1	IDH2,TBL1XR1,NCOR1
REGULATION OF MITOTIC SISTER CHROMATID SEPARATION%GOBP%GO:0010965	regulation of mitotic sister chromatid separation	0.02092908911660815	0.02092908911660815	+1	APC,RB1,ATM
NEGATIVE REGULATION OF GLIAL CELL-DERIVED NEUROTROPHIC FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN URETERIC BUD FORMATION%GOBP%GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	0.02092908911660815	0.02092908911660815	+1	GATA3
REGULATION OF CD4-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	0.02092908911660815	0.02092908911660815	+1	RUNX1,TGFBR2,CBFB
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN POSITIVE REGULATION OF CELL PROLIFERATION IN BONE MARROW%GOBP%GO:0035604	fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	0.02092908911660815	0.02092908911660815	+1	FGFR2
REGULATION OF GLYCOLYTIC PROCESS BY NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER%GOBP%GO:0072362	regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter	0.02092908911660815	0.02092908911660815	+1	NCOR1
NEGATIVE REGULATION OF STAT CASCADE%GOBP%GO:1904893	negative regulation of STAT cascade	0.02092908911660815	0.02092908911660815	+1	VHL,PPP2R1A
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN NEGATIVE REGULATION OF APOPTOTIC PROCESS IN BONE MARROW%GOBP%GO:0035602	fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow	0.02092908911660815	0.02092908911660815	+1	FGFR2
POSITIVE REGULATION OF PROTEIN UBIQUITINATION%GOBP%GO:0031398	positive regulation of protein ubiquitination	0.021505906695634347	0.021505906695634347	+1	PTEN,FBXW7,BRCA1,LRRK2
HALLMARK_ANDROGEN_RESPONSE%MSIGDB_C2%HALLMARK_ANDROGEN_RESPONSE	HALLMARK_ANDROGEN_RESPONSE	0.021505906695634347	0.021505906695634347	+1	AKT1,ARID5B,CCND1,LIFR
B CELL ACTIVATION%PANTHER PATHWAY%P00010	B cell activation	0.02181706102115248	0.02181706102115248	+1	PIK3CA,NRAS,PIK3CG
TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS	TCR signaling in naive CD8+ T cells	0.02181706102115248	0.02181706102115248	+1	KRAS,NRAS,AKT1
PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY	PID_CD8_TCR_PATHWAY	0.02181706102115248	0.02181706102115248	+1	KRAS,NRAS,AKT1
PEPTIDYL-LYSINE MODIFICATION%GOBP%GO:0018205	peptidyl-lysine modification	0.022388138021929817	0.022388138021929817	+1	KDM6A,TET2,SETD2,EP300,BRCA2,EZH2
NEGATIVE REGULATION OF OSTEOCLAST DIFFERENTIATION%GOBP%GO:0045671	negative regulation of osteoclast differentiation	0.022507181625599858	0.022507181625599858	+1	FBXW7,TLR4
SIGNALLING TO RAS%REACTOME%R-HSA-167044.4	Signalling to RAS	0.022507181625599858	0.022507181625599858	+1	KRAS,NRAS
FOREBRAIN NEURON DIFFERENTIATION%GOBP%GO:0021879	forebrain neuron differentiation	0.022507181625599858	0.022507181625599858	+1	ERBB4,FGFR2
NEGATIVE REGULATION OF MICROTUBULE DEPOLYMERIZATION%GOBP%GO:0007026	negative regulation of microtubule depolymerization	0.022507181625599858	0.022507181625599858	+1	APC,NAV3
RESPONSE TO CHOLESTEROL%GOBP%GO:0070723	response to cholesterol	0.022507181625599858	0.022507181625599858	+1	TGFBR2,SMAD2
METABOLISM OF COFACTORS%REACTOME%R-HSA-8978934.2	Metabolism of cofactors	0.022507181625599858	0.022507181625599858	+1	IDH1,AKT1
NEGATIVE REGULATION OF FIBROBLAST PROLIFERATION%GOBP%GO:0048147	negative regulation of fibroblast proliferation	0.022507181625599858	0.022507181625599858	+1	TP53,NF1
TRANSCRIPTION PREINITIATION COMPLEX ASSEMBLY%GOBP%GO:0070897	transcription preinitiation complex assembly	0.022507181625599858	0.022507181625599858	+1	TP53,TAF1
REGULATION OF WNT/B-CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20190610%WP3664%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3664_r94746	0.022507181625599858	0.022507181625599858	+1	APC,CTNNB1
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.2	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.022507181625599858	0.022507181625599858	+1	TP53,EP300
NEGATIVE REGULATION OF FATTY ACID METABOLIC PROCESS%GOBP%GO:0045922	negative regulation of fatty acid metabolic process	0.022507181625599858	0.022507181625599858	+1	AKT1,BRCA1
NOTCH1 REGULATION OF HUMAN ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20190610%WP3413%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3413_r87953	0.022507181625599858	0.022507181625599858	+1	NOTCH1,FGFR3
CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS%GOBP%GO:0002042	cell migration involved in sprouting angiogenesis	0.022507181625599858	0.022507181625599858	+1	AKT1,EGR3
SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 69%3232118	SUMOylation of transcription factors	0.022507181625599858	0.022507181625599858	+1	TP53,CDKN2A
4-HYDROXYTAMOXIFEN, DEXAMETHASONE, AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20190610%WP3879%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3879_r97670	0.022507181625599858	0.022507181625599858	+1	AKT1,MTOR
NEGATIVE REGULATION OF OXIDATIVE STRESS-INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	0.022507181625599858	0.022507181625599858	+1	NFE2L2,AKT1
RORA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 69%1368082	RORA activates gene expression	0.022507181625599858	0.022507181625599858	+1	EP300,TBL1XR1
TRANSCRIPTION CO-FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20190610%WP4533%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4533_r103380	0.022507181625599858	0.022507181625599858	+1	NF1,SIN3A
HALLMARK_TGF_BETA_SIGNALING%MSIGDB_C2%HALLMARK_TGF_BETA_SIGNALING	HALLMARK_TGF_BETA_SIGNALING	0.022638855681228556	0.022638855681228556	+1	APC,CTNNB1,CDH1
APOPTOSIS-RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20190610%WP2864%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2864_r79278	0.022638855681228556	0.022638855681228556	+1	AKT1,CDKN1B,CDKN1A
MUSCLE ORGAN MORPHOGENESIS%GOBP%GO:0048644	muscle organ morphogenesis	0.022638855681228556	0.022638855681228556	+1	NOTCH1,FGFR2,SMAD4
LEUKOCYTE PROLIFERATION%GOBP%GO:0070661	leukocyte proliferation	0.022638855681228556	0.022638855681228556	+1	FLT3,PIK3CG,KIT
VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS	Validated transcriptional targets of TAp63 isoforms	0.022638855681228556	0.022638855681228556	+1	CDKN2A,EP300,CDKN1A
MUSCLE TISSUE MORPHOGENESIS%GOBP%GO:0060415	muscle tissue morphogenesis	0.022638855681228556	0.022638855681228556	+1	NOTCH1,FGFR2,SMAD4
PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY	PID_TAP63_PATHWAY	0.022638855681228556	0.022638855681228556	+1	CDKN2A,EP300,CDKN1A
CELLULAR RESPONSE TO PEPTIDE%GOBP%GO:1901653	cellular response to peptide	0.022993566949481518	0.022993566949481518	+1	TP53,PIK3CA,APC,PIK3R1,AKT1,TLR4
SUDDEN INFANT DEATH SYNDROME (SIDS) SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20190610%WP706%HOMO SAPIENS	http://www.wikipathways.org/instance/WP706_r101924	0.023073201928350256	0.023073201928350256	+1	GATA3,CTNNB1,CTCF,AR,EP300
RNA LOCALIZATION%GOBP%GO:0006403	RNA localization	0.023073201928350256	0.023073201928350256	+1	NPM1,ATM,U2AF1,TGFBR2,ATR
PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS%GOBP%GO:0006661	phosphatidylinositol biosynthetic process	0.02335784963667234	0.02335784963667234	+1	PIK3CA,PTEN,PIK3R1,PIK3CG
ENSHEATHMENT OF NEURONS%GOBP%GO:0007272	ensheathment of neurons	0.023639950200937766	0.023639950200937766	+1	PTEN,NF1,PRX
RESPIRATORY SYSTEM DEVELOPMENT%GOBP%GO:0060541	respiratory system development	0.023639950200937766	0.023639950200937766	+1	CEBPA,WT1,FGFR2
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8941858.1	Regulation of RUNX3 expression and activity	0.023639950200937766	0.023639950200937766	+1	CDKN2A,EP300,CBFB
AXON ENSHEATHMENT%GOBP%GO:0008366	axon ensheathment	0.023639950200937766	0.023639950200937766	+1	PTEN,NF1,PRX
DNA METHYLATION OR DEMETHYLATION%GOBP%GO:0044728	DNA methylation or demethylation	0.023639950200937766	0.023639950200937766	+1	DNMT3A,TET2,ATRX
REGULATION OF CHROMOSOME SEPARATION%GOBP%GO:1905818	regulation of chromosome separation	0.023639950200937766	0.023639950200937766	+1	APC,RB1,ATM
PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20190610%WP2272%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2272_r97629	0.023639950200937766	0.023639950200937766	+1	CTNNB1,CDH1,TLR4
THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING	Thromboxane A2 receptor signaling	0.023639950200937766	0.023639950200937766	+1	EGFR,AKT1,PIK3CG
RANKL/RANK (RECEPTOR ACTIVATOR OF NFKB (LIGAND)) SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP2018%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2018_r90016	0.023639950200937766	0.023639950200937766	+1	PIK3R1,AKT1,MTOR
REGULATION OF GENE SILENCING BY MIRNA%GOBP%GO:0060964	regulation of gene silencing by miRNA	0.024006535791631995	0.024006535791631995	+1	TP53,EGFR,AJUBA,NCOR1
NEGATIVE REGULATION OF ALPHA-BETA T CELL DIFFERENTIATION%GOBP%GO:0046639	negative regulation of alpha-beta T cell differentiation	0.024427663307524602	0.024427663307524602	+1	RUNX1,CBFB
RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-HSA-442982.3	Ras activation upon Ca2+ influx through NMDA receptor	0.024427663307524602	0.024427663307524602	+1	KRAS,NRAS
MITOTIC SPINDLE ASSEMBLY CHECKPOINT%GOBP%GO:0007094	mitotic spindle assembly checkpoint	0.024427663307524602	0.024427663307524602	+1	APC,ATM
CCR9%IOB%CCR9	CCR9	0.024427663307524602	0.024427663307524602	+1	CDH1,AKT1
BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY	BIOCARTA_TOB1_PATHWAY	0.024427663307524602	0.024427663307524602	+1	SMAD4,TGFBR2
REGULATION OF UBIQUITIN PROTEIN LIGASE ACTIVITY%GOBP%GO:1904666	regulation of ubiquitin protein ligase activity	0.024427663307524602	0.024427663307524602	+1	PTEN,RPL5
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME DATABASE ID RELEASE 69%8876384	Listeria monocytogenes entry into host cells	0.024427663307524602	0.024427663307524602	+1	CTNNB1,CDH1
CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT%GOBP%GO:0061311	cell surface receptor signaling pathway involved in heart development	0.024427663307524602	0.024427663307524602	+1	NOTCH1,CTNNB1
CHROMATIN DISASSEMBLY%GOBP%GO:0031498	chromatin disassembly	0.024427663307524602	0.024427663307524602	+1	ARID1A,PBRM1
MITOTIC SPINDLE CHECKPOINT%GOBP%GO:0071174	mitotic spindle checkpoint	0.024427663307524602	0.024427663307524602	+1	APC,ATM
REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 69%210745	Regulation of gene expression in beta cells	0.024427663307524602	0.024427663307524602	+1	AKT1,FOXA2
SPINDLE ASSEMBLY CHECKPOINT%GOBP%GO:0071173	spindle assembly checkpoint	0.024427663307524602	0.024427663307524602	+1	APC,ATM
BONE MINERALIZATION%GOBP%GO:0030282	bone mineralization	0.024427663307524602	0.024427663307524602	+1	FGFR2,FGFR3
SKIN EPIDERMIS DEVELOPMENT%GOBP%GO:0098773	skin epidermis development	0.024427663307524602	0.024427663307524602	+1	SOX9,FGFR2
MOLTING CYCLE PROCESS%GOBP%GO:0022404	molting cycle process	0.024427663307524602	0.024427663307524602	+1	SOX9,FGFR2
SPINDLE CHECKPOINT%GOBP%GO:0031577	spindle checkpoint	0.024427663307524602	0.024427663307524602	+1	APC,ATM
EPITHELIAL STRUCTURE MAINTENANCE%GOBP%GO:0010669	epithelial structure maintenance	0.024427663307524602	0.024427663307524602	+1	SOX9,TLR4
EXCITATORY POSTSYNAPTIC POTENTIAL%GOBP%GO:0060079	excitatory postsynaptic potential	0.024427663307524602	0.024427663307524602	+1	AKT1,LRRK2
NUCLEOSOME DISASSEMBLY%GOBP%GO:0006337	nucleosome disassembly	0.024427663307524602	0.024427663307524602	+1	ARID1A,PBRM1
HAIR CYCLE PROCESS%GOBP%GO:0022405	hair cycle process	0.024427663307524602	0.024427663307524602	+1	SOX9,FGFR2
CELL FATE DETERMINATION%GOBP%GO:0001709	cell fate determination	0.024427663307524602	0.024427663307524602	+1	GATA3,SOX17
PEPTIDYL-LYSINE TRIMETHYLATION%GOBP%GO:0018023	peptidyl-lysine trimethylation	0.024427663307524602	0.024427663307524602	+1	TET2,SETD2
RESPONSE TO FLUID SHEAR STRESS%GOBP%GO:0034405	response to fluid shear stress	0.024427663307524602	0.024427663307524602	+1	NFE2L2,AKT1
RESPONSE TO NUTRIENT LEVELS%GOBP%GO:0031667	response to nutrient levels	0.02443282399783617	0.02443282399783617	+1	TP53,MTOR,LRRK2,FOXA2,CDKN1A,TAF1
REGULATION OF PROTEIN ACETYLATION%GOBP%GO:1901983	regulation of protein acetylation	0.024486708229110848	0.024486708229110848	+1	BRCA1,SMAD4,SIN3A
REGULATION OF POSTTRANSCRIPTIONAL GENE SILENCING%GOBP%GO:0060147	regulation of posttranscriptional gene silencing	0.02520880565815786	0.02520880565815786	+1	TP53,EGFR,AJUBA,NCOR1
REGULATION OF GENE SILENCING BY RNA%GOBP%GO:0060966	regulation of gene silencing by RNA	0.02520880565815786	0.02520880565815786	+1	TP53,EGFR,AJUBA,NCOR1
NUCLEOTIDE-EXCISION REPAIR%GOBP%GO:0006289	nucleotide-excision repair	0.02520880565815786	0.02520880565815786	+1	TP53,EP300,BRCA2,ERCC2
RESPONSE TO REACTIVE OXYGEN SPECIES%GOBP%GO:0000302	response to reactive oxygen species	0.02520880565815786	0.02520880565815786	+1	EGFR,NFE2L2,AKT1,PDGFRA
PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY	PID_TXA2PATHWAY	0.02561879017674863	0.02561879017674863	+1	EGFR,AKT1,PIK3CG
POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION%GOBP%GO:1903749	positive regulation of establishment of protein localization to mitochondrion	0.02561879017674863	0.02561879017674863	+1	TP53,FBXW7,BAP1
REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001236	regulation of extrinsic apoptotic signaling pathway	0.025967737543480123	0.025967737543480123	+1	PTEN,AKT1,AR,BRCA1
THERMOGENESIS%WIKIPATHWAYS_20190610%WP4321%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4321_r102774	0.025967737543480123	0.025967737543480123	+1	KRAS,ARID1A,NRAS,MTOR
SEPARATION OF SISTER CHROMATIDS%REACTOME%R-HSA-2467813.1	Separation of Sister Chromatids	0.026088444604772065	0.026088444604772065	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
ACTIVATION OF INNATE IMMUNE RESPONSE%GOBP%GO:0002218	activation of innate immune response	0.026290271636773072	0.026290271636773072	+1	KRAS,MAP3K1,NRAS,TLR4,EP300,SIN3A
PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY	PID_WNT_CANONICAL_PATHWAY	0.02661299612903458	0.02661299612903458	+1	APC,CTNNB1
SEROTONIN RECEPTOR 2 AND ELK-SRF/GATA4 SIGNALING%WIKIPATHWAYS_20190610%WP732%HOMO SAPIENS	http://www.wikipathways.org/instance/WP732_r101994	0.02661299612903458	0.02661299612903458	+1	KRAS,NRAS
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.1	NOTCH4 Intracellular Domain Regulates Transcription	0.02661299612903458	0.02661299612903458	+1	NOTCH1,EP300
BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY	BIOCARTA_NKCELLS_PATHWAY	0.02661299612903458	0.02661299612903458	+1	PIK3CA,PIK3R1
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.2	Role of LAT2 NTAL LAB on calcium mobilization	0.02661299612903458	0.02661299612903458	+1	PIK3CA,PIK3R1
REGULATION OF NUCLEASE ACTIVITY%GOBP%GO:0032069	regulation of nuclease activity	0.02661299612903458	0.02661299612903458	+1	NPM1,AKT1
NEGATIVE REGULATION OF MITOTIC METAPHASE/ANAPHASE TRANSITION%GOBP%GO:0045841	negative regulation of mitotic metaphase/anaphase transition	0.02661299612903458	0.02661299612903458	+1	APC,ATM
INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE BY P53 CLASS MEDIATOR%GOBP%GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	0.02661299612903458	0.02661299612903458	+1	TP53,EP300
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.1	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.02661299612903458	0.02661299612903458	+1	TP53,ATM
REGULATION OF BMP SIGNALING PATHWAY%GOBP%GO:0030510	regulation of BMP signaling pathway	0.02661299612903458	0.02661299612903458	+1	NOTCH1,SMAD4,SMAD2
CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS%GOBP%GO:0021955	central nervous system neuron axonogenesis	0.02661299612903458	0.02661299612903458	+1	PTEN,ARHGAP35
CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY	Canonical Wnt signaling pathway	0.02661299612903458	0.02661299612903458	+1	APC,CTNNB1
NUCLEOSOME ASSEMBLY%GOBP%GO:0006334	nucleosome assembly	0.02661299612903458	0.02661299612903458	+1	NPM1,SOX9,ATRX,HIST1H2BD
POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS%GOBP%GO:1900182	positive regulation of protein localization to nucleus	0.02661299612903458	0.02661299612903458	+1	PIK3R1,CDH1,AKT1
EMBRYONIC DIGESTIVE TRACT DEVELOPMENT%GOBP%GO:0048566	embryonic digestive tract development	0.02661299612903458	0.02661299612903458	+1	PDGFRA,FGFR2
REGULATION OF ENDOTHELIAL CELL PROLIFERATION%GOBP%GO:0001936	regulation of endothelial cell proliferation	0.02734926016487825	0.02734926016487825	+1	NF1,NRAS,AKT1,EGR3
REGULATION OF PEPTIDYL-SERINE PHOSPHORYLATION%GOBP%GO:0033135	regulation of peptidyl-serine phosphorylation	0.02734926016487825	0.02734926016487825	+1	EGFR,AKT1,BRAF,NSD1
ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004	Alzheimer disease-presenilin pathway	0.02734926016487825	0.02734926016487825	+1	NOTCH1,CTNNB1,CDH1,ERBB4
POSITIVE REGULATION OF INTRACELLULAR TRANSPORT%GOBP%GO:0032388	positive regulation of intracellular transport	0.027715724818828523	0.027715724818828523	+1	TP53,PIK3R1,FBXW7,CDH1,BAP1
NEGATIVE REGULATION OF PROTEIN UBIQUITINATION%GOBP%GO:0031397	negative regulation of protein ubiquitination	0.028847388134162995	0.028847388134162995	+1	AKT1,TAF1,RPL5
POSITIVE REGULATION OF DNA BIOSYNTHETIC PROCESS%GOBP%GO:2000573	positive regulation of DNA biosynthetic process	0.028847388134162995	0.028847388134162995	+1	ATM,HGF,ATR
BETA-CATENIN DESTRUCTION COMPLEX DISASSEMBLY%GOBP%GO:1904886	beta-catenin destruction complex disassembly	0.028847388134162995	0.028847388134162995	+1	APC,CTNNB1
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.1	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.028847388134162995	0.028847388134162995	+1	TP53,NPM1
POSITIVE REGULATION OF INTERFERON-ALPHA PRODUCTION%GOBP%GO:0032727	positive regulation of interferon-alpha production	0.028847388134162995	0.028847388134162995	+1	TLR4,SETD2
REGULATION OF CENTRIOLE REPLICATION%GOBP%GO:0046599	regulation of centriole replication	0.028847388134162995	0.028847388134162995	+1	NPM1,BRCA1
CELLULAR RESPONSE TO STARVATION%GOBP%GO:0009267	cellular response to starvation	0.028847388134162995	0.028847388134162995	+1	TP53,MTOR,LRRK2,CDKN1A
SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 69%187577	SCF(Skp2)-mediated degradation of p27 p21	0.028847388134162995	0.028847388134162995	+1	CDKN1B,CCND1,CDKN1A
RESPONSE TO LIPOPROTEIN PARTICLE%GOBP%GO:0055094	response to lipoprotein particle	0.028847388134162995	0.028847388134162995	+1	AKT1,TLR4
POSITIVE REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:1901798	positive regulation of signal transduction by p53 class mediator	0.028847388134162995	0.028847388134162995	+1	ATM,ATR
URETERIC BUD MORPHOGENESIS%GOBP%GO:0060675	ureteric bud morphogenesis	0.028847388134162995	0.028847388134162995	+1	GATA3,WT1
BONE MORPHOGENESIS%GOBP%GO:0060349	bone morphogenesis	0.028847388134162995	0.028847388134162995	+1	SOX9,FGFR2,FGFR3
SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS	Syndecan-3-mediated signaling events	0.028847388134162995	0.028847388134162995	+1	EGFR,FGFR3
NEGATIVE REGULATION OF METAPHASE/ANAPHASE TRANSITION OF CELL CYCLE%GOBP%GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	0.028847388134162995	0.028847388134162995	+1	APC,ATM
NGF%IOB%NGF	NGF	0.028847388134162995	0.028847388134162995	+1	BRAF,PTPN11
PREIMPLANTATION EMBRYO%WIKIPATHWAYS_20190610%WP3527%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3527_r94671	0.028847388134162995	0.028847388134162995	+1	GATA3,CDH1,TBX3
REGULATION OF ANOIKIS%GOBP%GO:2000209	regulation of anoikis	0.028847388134162995	0.028847388134162995	+1	PIK3CA,NOTCH1
PROTEIN-DNA COMPLEX DISASSEMBLY%GOBP%GO:0032986	protein-DNA complex disassembly	0.028847388134162995	0.028847388134162995	+1	ARID1A,PBRM1
REGULATION OF SMOOTH MUSCLE CELL DIFFERENTIATION%GOBP%GO:0051150	regulation of smooth muscle cell differentiation	0.028847388134162995	0.028847388134162995	+1	KIT,FGFR2
POSITIVE REGULATION OF LEUKOCYTE APOPTOTIC PROCESS%GOBP%GO:2000108	positive regulation of leukocyte apoptotic process	0.028847388134162995	0.028847388134162995	+1	TP53,CDKN2A
MRNA TRANSCRIPTION%GOBP%GO:0009299	mRNA transcription	0.028847388134162995	0.028847388134162995	+1	TP53,SOX17
HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20190610%WP2849%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2849_r103039	0.028847388134162995	0.028847388134162995	+1	NOTCH1,RUNX1,ACVR1B
ENDOTHELIAL CELL DIFFERENTIATION%GOBP%GO:0045446	endothelial cell differentiation	0.028847388134162995	0.028847388134162995	+1	NOTCH1,SMAD4,SOX17
REGULATION OF LYMPHOCYTE DIFFERENTIATION%GOBP%GO:0045619	regulation of lymphocyte differentiation	0.02955479441774658	0.02955479441774658	+1	GATA3,RUNX1,TGFBR2,CBFB
CELLULAR RESPONSE TO ACID CHEMICAL%GOBP%GO:0071229	cellular response to acid chemical	0.02955479441774658	0.02955479441774658	+1	EPHA3,SOX9,ATM,MTOR
RESPONSE TO NUTRIENT%GOBP%GO:0007584	response to nutrient	0.02998290176809792	0.02998290176809792	+1	MTOR,FOXA2,TAF1
POSITIVE REGULATION OF NIK/NF-KAPPAB SIGNALING%GOBP%GO:1901224	positive regulation of NIK/NF-kappaB signaling	0.02998290176809792	0.02998290176809792	+1	EGFR,TLR4,EP300
MIDBRAIN DEVELOPMENT%GOBP%GO:0030901	midbrain development	0.02998290176809792	0.02998290176809792	+1	CTNNB1,FGFR2,TAF1
NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS%GOBP%GO:0090288	negative regulation of cellular response to growth factor stimulus	0.0303850702616435	0.0303850702616435	+1	GATA3,NOTCH1,TGFBR2,SMAD2
MITOTIC ANAPHASE%REACTOME%R-HSA-68882.2	Mitotic Anaphase	0.030612314560318946	0.030612314560318946	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 69%3371571	HSF1-dependent transactivation	0.03106208331960172	0.03106208331960172	+1	MTOR,EP300
NEGATIVE REGULATION OF MITOTIC SISTER CHROMATID SEPARATION%GOBP%GO:2000816	negative regulation of mitotic sister chromatid separation	0.03106208331960172	0.03106208331960172	+1	APC,ATM
M-CSF%IOB%M-CSF	M-CSF	0.03106208331960172	0.03106208331960172	+1	PIK3R1,AKT1,PTPN11
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME DATABASE ID RELEASE 69%452723	Transcriptional regulation of pluripotent stem cells	0.03106208331960172	0.03106208331960172	+1	SMAD4,SMAD2
RESPONSE TO STEROL%GOBP%GO:0036314	response to sterol	0.03106208331960172	0.03106208331960172	+1	TGFBR2,SMAD2
ENDOCRINE PANCREAS DEVELOPMENT%GOBP%GO:0031018	endocrine pancreas development	0.03106208331960172	0.03106208331960172	+1	AKT1,FOXA2
CELLULAR RESPONSE TO LIPOPROTEIN PARTICLE STIMULUS%GOBP%GO:0071402	cellular response to lipoprotein particle stimulus	0.03106208331960172	0.03106208331960172	+1	AKT1,TLR4
SIGNALING BY BRAF AND RAF FUSIONS%REACTOME%R-HSA-6802952.1	Signaling by BRAF and RAF fusions	0.03106208331960172	0.03106208331960172	+1	KRAS,NRAS,BRAF
DENDRITIC CELL DIFFERENTIATION%GOBP%GO:0097028	dendritic cell differentiation	0.03106208331960172	0.03106208331960172	+1	FLT3,TGFBR2
NEGATIVE REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION%GOBP%GO:0051154	negative regulation of striated muscle cell differentiation	0.03106208331960172	0.03106208331960172	+1	NOTCH1,SMAD4
REGULATION OF MICROTUBULE DEPOLYMERIZATION%GOBP%GO:0031114	regulation of microtubule depolymerization	0.03106208331960172	0.03106208331960172	+1	APC,NAV3
VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20190610%WP4482%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4482_r103405	0.03106208331960172	0.03106208331960172	+1	MAP3K1,SMAD4
HISTONE DEUBIQUITINATION%GOBP%GO:0016578	histone deubiquitination	0.03106208331960172	0.03106208331960172	+1	BAP1,ASXL1
E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.3	E2F mediated regulation of DNA replication	0.03106208331960172	0.03106208331960172	+1	RB1,PPP2R1A
BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY	BIOCARTA_CERAMIDE_PATHWAY	0.03106208331960172	0.03106208331960172	+1	MAP3K1,MAP2K4
DNA DOUBLE-STRAND BREAK PROCESSING%GOBP%GO:0000729	DNA double-strand break processing	0.03106208331960172	0.03106208331960172	+1	ATM,BRCA1
REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 69%400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	0.03106208331960172	0.03106208331960172	+1	EP300,SIN3A,TBL1XR1,NCOR1
MITOTIC METAPHASE AND ANAPHASE%REACTOME%R-HSA-2555396.2	Mitotic Metaphase and Anaphase	0.03106208331960172	0.03106208331960172	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
NEPHRIN FAMILY INTERACTIONS%REACTOME%R-HSA-373753.3	Nephrin family interactions	0.03106208331960172	0.03106208331960172	+1	PIK3CA,PIK3R1
REGULATION OF APOPTOSIS BY PARATHYROID HORMONE-RELATED PROTEIN%WIKIPATHWAYS_20190610%WP3872%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3872_r89397	0.03106208331960172	0.03106208331960172	+1	AKT1,PIK3CG
BLOOD VESSEL ENDOTHELIAL CELL MIGRATION%GOBP%GO:0043534	blood vessel endothelial cell migration	0.03106208331960172	0.03106208331960172	+1	AKT1,EGR3
CELL CHEMOTAXIS%GOBP%GO:0060326	cell chemotaxis	0.03106208331960172	0.03106208331960172	+1	PIK3CG,HGF,KIT,PDGFRA,EGR3
POSITIVE REGULATION OF ERYTHROCYTE DIFFERENTIATION%GOBP%GO:0045648	positive regulation of erythrocyte differentiation	0.03106208331960172	0.03106208331960172	+1	ACVR1B,ACVR2A
POSITIVE REGULATION OF TRANSCRIPTION BY RNA POLYMERASE I%GOBP%GO:0045943	positive regulation of transcription by RNA polymerase I	0.03106208331960172	0.03106208331960172	+1	MTOR,TAF1
WNT SIGNALING%WIKIPATHWAYS_20190610%WP428%HOMO SAPIENS	http://www.wikipathways.org/instance/WP428_r102324	0.03178589796534417	0.03178589796534417	+1	APC,CTNNB1,CCND1,SOX17
POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION%GOBP%GO:0045639	positive regulation of myeloid cell differentiation	0.03223782417868779	0.03223782417868779	+1	RUNX1,ACVR1B,ACVR2A
G2 M TRANSITION%REACTOME DATABASE ID RELEASE 69%69275	G2 M Transition	0.03224776948963782	0.03224776948963782	+1	TP53,AJUBA,EP300,CDKN1A,PPP2R1A
FC RECEPTOR SIGNALING PATHWAY%GOBP%GO:0038093	Fc receptor signaling pathway	0.03224776948963782	0.03224776948963782	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4,KIT
MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 69%68877	Mitotic Prometaphase	0.03224776948963782	0.03224776948963782	+1	STAG2,PPP2R1A,SMC1A,SMC3,RAD21
POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL%GOBP%GO:1903322	positive regulation of protein modification by small protein conjugation or removal	0.032632678972352405	0.032632678972352405	+1	PTEN,FBXW7,BRCA1,LRRK2
NEGATIVE REGULATION OF CD4-POSITIVE, ALPHA-BETA T CELL ACTIVATION%GOBP%GO:2000515	negative regulation of CD4-positive, alpha-beta T cell activation	0.033362103161144005	0.033362103161144005	+1	RUNX1,CBFB
NADP METABOLIC PROCESS%GOBP%GO:0006739	NADP metabolic process	0.033362103161144005	0.033362103161144005	+1	IDH1,IDH2
REGULATION OF B CELL RECEPTOR SIGNALING PATHWAY%GOBP%GO:0050855	regulation of B cell receptor signaling pathway	0.033362103161144005	0.033362103161144005	+1	RUNX1,CBFB
MESONEPHRIC TUBULE MORPHOGENESIS%GOBP%GO:0072171	mesonephric tubule morphogenesis	0.033362103161144005	0.033362103161144005	+1	GATA3,WT1
PHOTODYNAMIC THERAPY-INDUCED NFE2L2 (NRF2) SURVIVAL SIGNALING%WIKIPATHWAYS_20190610%WP3612%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3612_r95149	0.033362103161144005	0.033362103161144005	+1	KEAP1,NFE2L2
POSITIVE REGULATION OF DNA REPLICATION%GOBP%GO:0045740	positive regulation of DNA replication	0.033362103161144005	0.033362103161144005	+1	EGFR,ATRX
NEGATIVE REGULATION OF MAP KINASE ACTIVITY%GOBP%GO:0043407	negative regulation of MAP kinase activity	0.033362103161144005	0.033362103161144005	+1	NF1,PPP2R1A,MAPK8IP1
RESPONSE TO GROWTH HORMONE%GOBP%GO:0060416	response to growth hormone	0.033362103161144005	0.033362103161144005	+1	PIK3R1,AKT1
POSITIVE REGULATION OF CELL CYCLE G2/M PHASE TRANSITION%GOBP%GO:1902751	positive regulation of cell cycle G2/M phase transition	0.033362103161144005	0.033362103161144005	+1	NPM1,CCND1
DETERMINATION OF LEFT/RIGHT SYMMETRY%GOBP%GO:0007368	determination of left/right symmetry	0.033362103161144005	0.033362103161144005	+1	NOTCH1,TGFBR2,SOX17
HUNTINGTON DISEASE%PANTHER PATHWAY%P00029	Huntington disease	0.033362103161144005	0.033362103161144005	+1	TP53,MAP2K4,AKT1,EP300
REGULATION OF TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER%GOBP%GO:0060260	regulation of transcription initiation from RNA polymerase II promoter	0.033362103161144005	0.033362103161144005	+1	TP53,TAF1
MYOBLAST DIFFERENTIATION%GOBP%GO:0045445	myoblast differentiation	0.033362103161144005	0.033362103161144005	+1	RB1,NOTCH1
POSITIVE REGULATION OF HISTONE ACETYLATION%GOBP%GO:0035066	positive regulation of histone acetylation	0.033362103161144005	0.033362103161144005	+1	BRCA1,SMAD4
PROTEASOMAL UBIQUITIN-INDEPENDENT PROTEIN CATABOLIC PROCESS%GOBP%GO:0010499	proteasomal ubiquitin-independent protein catabolic process	0.033362103161144005	0.033362103161144005	+1	KEAP1,NFE2L2
OLIGODENDROCYTE DIFFERENTIATION%GOBP%GO:0048709	oligodendrocyte differentiation	0.033362103161144005	0.033362103161144005	+1	PTEN,SOX9
NEGATIVE REGULATION OF CHROMOSOME SEPARATION%GOBP%GO:1905819	negative regulation of chromosome separation	0.033362103161144005	0.033362103161144005	+1	APC,ATM
REGULATION OF DENDRITIC SPINE MORPHOGENESIS%GOBP%GO:0061001	regulation of dendritic spine morphogenesis	0.033362103161144005	0.033362103161144005	+1	PTEN,LRRK2
LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS	LPA receptor mediated events	0.033362103161144005	0.033362103161144005	+1	EGFR,PIK3R1,AKT1
MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 69%453274	Mitotic G2-G2 M phases	0.033362103161144005	0.033362103161144005	+1	TP53,AJUBA,EP300,CDKN1A,PPP2R1A
INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033	Insulin IGF pathway-protein kinase B signaling cascade	0.033362103161144005	0.033362103161144005	+1	PIK3CA,PTEN
BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY	BIOCARTA_NFKB_PATHWAY	0.033362103161144005	0.033362103161144005	+1	MAP3K1,TLR4
ACTIVATION OF MAPK ACTIVITY%GOBP%GO:0000187	activation of MAPK activity	0.034117884401531226	0.034117884401531226	+1	MAP2K4,TLR4,LRRK2,KIT
FC-EPSILON RECEPTOR SIGNALING PATHWAY%GOBP%GO:0038095	Fc-epsilon receptor signaling pathway	0.034117884401531226	0.034117884401531226	+1	PIK3CA,PIK3R1,MAP3K1,MAP2K4
POSITIVE REGULATION OF HISTONE MODIFICATION%GOBP%GO:0031058	positive regulation of histone modification	0.034508714751667294	0.034508714751667294	+1	CTNNB1,BRCA1,SMAD4
PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY	PID_CD8_TCR_DOWNSTREAM_PATHWAY	0.034508714751667294	0.034508714751667294	+1	KRAS,NRAS,BRAF
NEGATIVE REGULATION OF LIPID METABOLIC PROCESS%GOBP%GO:0045833	negative regulation of lipid metabolic process	0.034508714751667294	0.034508714751667294	+1	FBXW7,AKT1,BRCA1
AXON GUIDANCE%GOBP%GO:0007411	axon guidance	0.034653818149580774	0.034653818149580774	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,PTPN11
NEGATIVE REGULATION OF WNT SIGNALING PATHWAY%GOBP%GO:0030178	negative regulation of Wnt signaling pathway	0.034653818149580774	0.034653818149580774	+1	APC,STK11,SOX9,SOX17,AXIN2
CELLULAR RESPONSE TO INSULIN STIMULUS%GOBP%GO:0032869	cellular response to insulin stimulus	0.0349794346945233	0.0349794346945233	+1	PIK3CA,APC,PIK3R1,AKT1
REGULATION OF LOCOMOTOR RHYTHM%GOBP%GO:1904059	regulation of locomotor rhythm	0.0353200074405027	0.0353200074405027	+1	MTOR
MAMMARY GLAND SPECIFICATION%GOBP%GO:0060594	mammary gland specification	0.0353200074405027	0.0353200074405027	+1	FGFR2
EMBRYONIC FOREGUT MORPHOGENESIS%GOBP%GO:0048617	embryonic foregut morphogenesis	0.0353200074405027	0.0353200074405027	+1	SOX17
NEGATIVE REGULATION OF INTEGRIN BIOSYNTHETIC PROCESS%GOBP%GO:0045720	negative regulation of integrin biosynthetic process	0.0353200074405027	0.0353200074405027	+1	AR
REGULATION OF B CELL TOLERANCE INDUCTION%GOBP%GO:0002661	regulation of B cell tolerance induction	0.0353200074405027	0.0353200074405027	+1	TGFBR2
LUNG-ASSOCIATED MESENCHYME DEVELOPMENT%GOBP%GO:0060484	lung-associated mesenchyme development	0.0353200074405027	0.0353200074405027	+1	FGFR2
NEGATIVE REGULATION OF FEMALE GONAD DEVELOPMENT%GOBP%GO:2000195	negative regulation of female gonad development	0.0353200074405027	0.0353200074405027	+1	WT1
FOREBRAIN VENTRICULAR ZONE PROGENITOR CELL DIVISION%GOBP%GO:0021869	forebrain ventricular zone progenitor cell division	0.0353200074405027	0.0353200074405027	+1	FGFR2
REPLICATIVE CELL AGING%GOBP%GO:0001302	replicative cell aging	0.0353200074405027	0.0353200074405027	+1	CHEK2
PARAXIAL MESODERM DEVELOPMENT%GOBP%GO:0048339	paraxial mesoderm development	0.0353200074405027	0.0353200074405027	+1	SMAD2
CELLULAR RESPONSE TO FOLLICLE-STIMULATING HORMONE STIMULUS%GOBP%GO:0071372	cellular response to follicle-stimulating hormone stimulus	0.0353200074405027	0.0353200074405027	+1	NOTCH1
RETINAL ROD CELL DIFFERENTIATION%GOBP%GO:0060221	retinal rod cell differentiation	0.0353200074405027	0.0353200074405027	+1	SOX9
NEURON PROJECTION GUIDANCE%GOBP%GO:0097485	neuron projection guidance	0.0353200074405027	0.0353200074405027	+1	PIK3CA,PIK3R1,ARHGAP35,EPHA3,PTPN11
CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS%GOBP%GO:0061323	cell proliferation involved in heart morphogenesis	0.0353200074405027	0.0353200074405027	+1	TGFBR2
REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.1	Regulation of TP53 Expression	0.0353200074405027	0.0353200074405027	+1	TP53
GONADOTROPIN SECRETION%GOBP%GO:0032274	gonadotropin secretion	0.0353200074405027	0.0353200074405027	+1	TBX3
FOREGUT MORPHOGENESIS%GOBP%GO:0007440	foregut morphogenesis	0.0353200074405027	0.0353200074405027	+1	SOX17
RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951911.1	RUNX3 regulates RUNX1-mediated transcription	0.0353200074405027	0.0353200074405027	+1	CBFB
NEGATIVE REGULATION OF SREBP SIGNALING PATHWAY%GOBP%GO:2000639	negative regulation of SREBP signaling pathway	0.0353200074405027	0.0353200074405027	+1	FBXW7
BRANCHING INVOLVED IN PROSTATE GLAND MORPHOGENESIS%GOBP%GO:0060442	branching involved in prostate gland morphogenesis	0.0353200074405027	0.0353200074405027	+1	FGFR2
RESPONSE TO INSULIN-LIKE GROWTH FACTOR STIMULUS%GOBP%GO:1990418	response to insulin-like growth factor stimulus	0.0353200074405027	0.0353200074405027	+1	AKT1
MIRNA TRANSPORT%GOBP%GO:1990428	miRNA transport	0.0353200074405027	0.0353200074405027	+1	TGFBR2
MELANOCYTE MIGRATION%GOBP%GO:0097324	melanocyte migration	0.0353200074405027	0.0353200074405027	+1	KIT
BUTYRATE-INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20190610%WP2366%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2366_r102201	0.0353200074405027	0.0353200074405027	+1	AKT1
REGULATION OF CELLULAR RESPONSE TO X-RAY%GOBP%GO:2000683	regulation of cellular response to X-ray	0.0353200074405027	0.0353200074405027	+1	GATA3
NEGATIVE REGULATION OF TRIGLYCERIDE BIOSYNTHETIC PROCESS%GOBP%GO:0010868	negative regulation of triglyceride biosynthetic process	0.0353200074405027	0.0353200074405027	+1	FBXW7
POSITIVE REGULATION OF HISTONE H4-K16 ACETYLATION%GOBP%GO:2000620	positive regulation of histone H4-K16 acetylation	0.0353200074405027	0.0353200074405027	+1	BRCA1
POSITIVE REGULATION OF COLLAGEN FIBRIL ORGANIZATION%GOBP%GO:1904028	positive regulation of collagen fibril organization	0.0353200074405027	0.0353200074405027	+1	RB1
CORONARY VEIN MORPHOGENESIS%GOBP%GO:0003169	coronary vein morphogenesis	0.0353200074405027	0.0353200074405027	+1	NOTCH1
ROLE OF OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20190610%WP3971%HOMO SAPIENS	http://www.wikipathways.org/instance/WP3971_r91525	0.0353200074405027	0.0353200074405027	+1	NOTCH1,CTNNB1
REGULATION OF METANEPHRIC URETERIC BUD DEVELOPMENT%GOBP%GO:2001074	regulation of metanephric ureteric bud development	0.0353200074405027	0.0353200074405027	+1	WT1
LEFT VENTRICULAR CARDIAC MUSCLE TISSUE MORPHOGENESIS%GOBP%GO:0003220	left ventricular cardiac muscle tissue morphogenesis	0.0353200074405027	0.0353200074405027	+1	SMAD4
CARDIAC VASCULAR SMOOTH MUSCLE CELL DEVELOPMENT%GOBP%GO:0060948	cardiac vascular smooth muscle cell development	0.0353200074405027	0.0353200074405027	+1	NOTCH1
TRANSCRIPTION FACTOR CATABOLIC PROCESS%GOBP%GO:0036369	transcription factor catabolic process	0.0353200074405027	0.0353200074405027	+1	TAF1
EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 69%9630791	Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	0.0353200074405027	0.0353200074405027	+1	CDKN2A
PYRAMIDAL NEURON DIFFERENTIATION%GOBP%GO:0021859	pyramidal neuron differentiation	0.0353200074405027	0.0353200074405027	+1	FGFR2
STEM CELL FATE SPECIFICATION%GOBP%GO:0048866	stem cell fate specification	0.0353200074405027	0.0353200074405027	+1	SOX9
VENTRICULAR ZONE NEUROBLAST DIVISION%GOBP%GO:0021847	ventricular zone neuroblast division	0.0353200074405027	0.0353200074405027	+1	FGFR2
CENTRAL NERVOUS SYSTEM MORPHOGENESIS%GOBP%GO:0021551	central nervous system morphogenesis	0.0353200074405027	0.0353200074405027	+1	ERBB4
HISTONE H2B ACETYLATION%GOBP%GO:0043969	histone H2B acetylation	0.0353200074405027	0.0353200074405027	+1	EP300
RESPONSE TO STEM CELL FACTOR%GOBP%GO:0036215	response to stem cell factor	0.0353200074405027	0.0353200074405027	+1	KIT
FASCICULATION OF MOTOR NEURON AXON%GOBP%GO:0097156	fasciculation of motor neuron axon	0.0353200074405027	0.0353200074405027	+1	EPHA3
POSITIVE REGULATION OF PROTEIN AUTOUBIQUITINATION%GOBP%GO:1902499	positive regulation of protein autoubiquitination	0.0353200074405027	0.0353200074405027	+1	LRRK2
NEGATIVE REGULATION OF NEUROBLAST PROLIFERATION%GOBP%GO:0007406	negative regulation of neuroblast proliferation	0.0353200074405027	0.0353200074405027	+1	NF1
NEGATIVE REGULATION OF VACUOLAR TRANSPORT%GOBP%GO:1903336	negative regulation of vacuolar transport	0.0353200074405027	0.0353200074405027	+1	LRRK2
CELLULAR RESPONSE TO NITROSATIVE STRESS%GOBP%GO:0071500	cellular response to nitrosative stress	0.0353200074405027	0.0353200074405027	+1	ATM
NEGATIVE REGULATION OF PROTEIN AUTOUBIQUITINATION%GOBP%GO:1905524	negative regulation of protein autoubiquitination	0.0353200074405027	0.0353200074405027	+1	TAF1
NEURAL CREST CELL FATE SPECIFICATION%GOBP%GO:0014036	neural crest cell fate specification	0.0353200074405027	0.0353200074405027	+1	SOX9
TREHALOSE METABOLIC PROCESS%GOBP%GO:0005991	trehalose metabolic process	0.0353200074405027	0.0353200074405027	+1	BRAF
REGULATION OF HISTONE H3-K27 ACETYLATION%GOBP%GO:1901674	regulation of histone H3-K27 acetylation	0.0353200074405027	0.0353200074405027	+1	SIN3A
NEGATIVE REGULATION OF HEPATOCYTE PROLIFERATION%GOBP%GO:2000346	negative regulation of hepatocyte proliferation	0.0353200074405027	0.0353200074405027	+1	FBXW7
NEGATIVE REGULATION OF INTERLEUKIN-23 PRODUCTION%GOBP%GO:0032707	negative regulation of interleukin-23 production	0.0353200074405027	0.0353200074405027	+1	TLR4
NEGATIVE REGULATION OF MYOFIBROBLAST DIFFERENTIATION%GOBP%GO:1904761	negative regulation of myofibroblast differentiation	0.0353200074405027	0.0353200074405027	+1	RB1
MAMMARY GLAND FORMATION%GOBP%GO:0060592	mammary gland formation	0.0353200074405027	0.0353200074405027	+1	FGFR2
REGULATION OF PEROXIDASE ACTIVITY%GOBP%GO:2000468	regulation of peroxidase activity	0.0353200074405027	0.0353200074405027	+1	LRRK2
RENAL VESICLE INDUCTION%GOBP%GO:0072034	renal vesicle induction	0.0353200074405027	0.0353200074405027	+1	SOX9
PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY	PID_LYSOPHOSPHOLIPID_PATHWAY	0.0353200074405027	0.0353200074405027	+1	EGFR,PIK3R1,AKT1
GLIAL CELL APOPTOTIC PROCESS%GOBP%GO:0034349	glial cell apoptotic process	0.0353200074405027	0.0353200074405027	+1	TP53
PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY	PID_HDAC_CLASSI_PATHWAY	0.0353200074405027	0.0353200074405027	+1	EP300,SIN3A,NCOR1
PROTEIN KINASE B SIGNALING%GOBP%GO:0043491	protein kinase B signaling	0.0353200074405027	0.0353200074405027	+1	PTEN,AKT1
ADRENAL CORTEX FORMATION%GOBP%GO:0035802	adrenal cortex formation	0.0353200074405027	0.0353200074405027	+1	WT1
PRIMARY SEX DETERMINATION%GOBP%GO:0007538	primary sex determination	0.0353200074405027	0.0353200074405027	+1	SOX9
ZYGOTIC SPECIFICATION OF DORSAL/VENTRAL AXIS%GOBP%GO:0007352	zygotic specification of dorsal/ventral axis	0.0353200074405027	0.0353200074405027	+1	SMAD2
PYRAMIDAL NEURON DEVELOPMENT%GOBP%GO:0021860	pyramidal neuron development	0.0353200074405027	0.0353200074405027	+1	FGFR2
DNA STRAND RENATURATION%GOBP%GO:0000733	DNA strand renaturation	0.0353200074405027	0.0353200074405027	+1	TP53
KIT SIGNALING PATHWAY%GOBP%GO:0038109	Kit signaling pathway	0.0353200074405027	0.0353200074405027	+1	KIT
MAST CELL DIFFERENTIATION%GOBP%GO:0060374	mast cell differentiation	0.0353200074405027	0.0353200074405027	+1	KIT
POSTERIOR MESONEPHRIC TUBULE DEVELOPMENT%GOBP%GO:0072166	posterior mesonephric tubule development	0.0353200074405027	0.0353200074405027	+1	WT1
REGULATION OF LIPID TRANSPORT BY NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER%GOBP%GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter	0.0353200074405027	0.0353200074405027	+1	NCOR1
EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 69%9632697	Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	0.0353200074405027	0.0353200074405027	+1	CDKN2A
HISTONE H3-K4 METHYLATION%GOBP%GO:0051568	histone H3-K4 methylation	0.0353200074405027	0.0353200074405027	+1	KDM6A,TET2
POSITIVE REGULATION OF NODAL SIGNALING PATHWAY INVOLVED IN DETERMINATION OF LATERAL MESODERM LEFT/RIGHT ASYMMETRY%GOBP%GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	0.0353200074405027	0.0353200074405027	+1	SMAD2
DETECTION OF FUNGUS%GOBP%GO:0016046	detection of fungus	0.0353200074405027	0.0353200074405027	+1	TLR4
PARAXIAL MESODERM MORPHOGENESIS%GOBP%GO:0048340	paraxial mesoderm morphogenesis	0.0353200074405027	0.0353200074405027	+1	SMAD2
MYELOID PROGENITOR CELL DIFFERENTIATION%GOBP%GO:0002318	myeloid progenitor cell differentiation	0.0353200074405027	0.0353200074405027	+1	FLT3
INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.6	Interleukin-6 family signaling	0.0353200074405027	0.0353200074405027	+1	PTPN11,LIFR
REGULATION OF CARBOHYDRATE CATABOLIC PROCESS BY REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER%GOBP%GO:0098679	regulation of carbohydrate catabolic process by regulation of transcription from RNA polymerase II promoter	0.0353200074405027	0.0353200074405027	+1	NCOR1
RHYTHMIC SYNAPTIC TRANSMISSION%GOBP%GO:0060024	rhythmic synaptic transmission	0.0353200074405027	0.0353200074405027	+1	PTEN
DENDRITIC CELL CYTOKINE PRODUCTION%GOBP%GO:0002371	dendritic cell cytokine production	0.0353200074405027	0.0353200074405027	+1	KIT
AGE/RAGE PATHWAY%WIKIPATHWAYS_20190610%WP2324%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2324_r96980	0.0353200074405027	0.0353200074405027	+1	EGFR,AKT1,SMAD2
OLIGODENDROCYTE APOPTOTIC PROCESS%GOBP%GO:0097252	oligodendrocyte apoptotic process	0.0353200074405027	0.0353200074405027	+1	TP53
ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20190610%WP474%HOMO SAPIENS	http://www.wikipathways.org/instance/WP474_r95499	0.0353200074405027	0.0353200074405027	+1	AKT1,SOX9,FGFR3
ENDODERMAL DIGESTIVE TRACT MORPHOGENESIS%GOBP%GO:0061031	endodermal digestive tract morphogenesis	0.0353200074405027	0.0353200074405027	+1	SOX17
MAMMARY GLAND INVOLUTION%GOBP%GO:0060056	mammary gland involution	0.0353200074405027	0.0353200074405027	+1	ELF3
ADRENAL CORTEX DEVELOPMENT%GOBP%GO:0035801	adrenal cortex development	0.0353200074405027	0.0353200074405027	+1	WT1
REGULATION OF MYOFIBROBLAST DIFFERENTIATION%GOBP%GO:1904760	regulation of myofibroblast differentiation	0.0353200074405027	0.0353200074405027	+1	RB1
RRNA EXPORT FROM NUCLEUS%GOBP%GO:0006407	rRNA export from nucleus	0.0353200074405027	0.0353200074405027	+1	NPM1
CARDIAC MUSCLE TISSUE REGENERATION%GOBP%GO:0061026	cardiac muscle tissue regeneration	0.0353200074405027	0.0353200074405027	+1	ERBB4
MAST CELL CYTOKINE PRODUCTION%GOBP%GO:0032762	mast cell cytokine production	0.0353200074405027	0.0353200074405027	+1	KIT
NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO UV-INDUCED DNA DAMAGE%GOBP%GO:0010768	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	0.0353200074405027	0.0353200074405027	+1	TAF1
BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY	BIOCARTA_CXCR4_PATHWAY	0.0353200074405027	0.0353200074405027	+1	PIK3CA,PIK3R1
SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I	Signaling events mediated by HDAC Class I	0.0353200074405027	0.0353200074405027	+1	EP300,SIN3A,NCOR1
REGULATION OF GLYCOLYTIC PROCESS BY REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER%GOBP%GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter	0.0353200074405027	0.0353200074405027	+1	NCOR1
REGULATION OF APOPTOTIC PROCESS IN BONE MARROW%GOBP%GO:0071865	regulation of apoptotic process in bone marrow	0.0353200074405027	0.0353200074405027	+1	FGFR2
NEGATIVE REGULATION OF MITOTIC CELL CYCLE, EMBRYONIC%GOBP%GO:0045976	negative regulation of mitotic cell cycle, embryonic	0.0353200074405027	0.0353200074405027	+1	CTNNB1
POSITIVE REGULATION OF METANEPHRIC URETERIC BUD DEVELOPMENT%GOBP%GO:2001076	positive regulation of metanephric ureteric bud development	0.0353200074405027	0.0353200074405027	+1	WT1
REGULATION OF HEMOSTASIS%GOBP%GO:1900046	regulation of hemostasis	0.0353200074405027	0.0353200074405027	+1	TLR4,PDGFRA,FOXA2
NEGATIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT%GOBP%GO:0070168	negative regulation of biomineral tissue development	0.0353200074405027	0.0353200074405027	+1	NOTCH1,SOX9
FORMATION OF PRIMARY GERM LAYER%GOBP%GO:0001704	formation of primary germ layer	0.0353200074405027	0.0353200074405027	+1	SETD2,SOX17,SMAD2
POSITIVE REGULATION OF OXIDATIVE STRESS-INDUCED NEURON INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	0.0353200074405027	0.0353200074405027	+1	FBXW7
POSITIVE REGULATION OF RNA POLYMERASE II REGULATORY REGION SEQUENCE-SPECIFIC DNA BINDING%GOBP%GO:1905636	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding	0.0353200074405027	0.0353200074405027	+1	EP300
REGULATION OF BLOOD COAGULATION%GOBP%GO:0030193	regulation of blood coagulation	0.0353200074405027	0.0353200074405027	+1	TLR4,PDGFRA,FOXA2
MODULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL%GOBP%GO:0098815	modulation of excitatory postsynaptic potential	0.0353200074405027	0.0353200074405027	+1	PTEN,LRRK2
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY INVOLVED IN MAMMARY GLAND SPECIFICATION%GOBP%GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	0.0353200074405027	0.0353200074405027	+1	FGFR2
NEGATIVE REGULATION OF MITOTIC CELL CYCLE DNA REPLICATION%GOBP%GO:1903464	negative regulation of mitotic cell cycle DNA replication	0.0353200074405027	0.0353200074405027	+1	CHEK2
NEGATIVE REGULATION OF LATE ENDOSOME TO LYSOSOME TRANSPORT%GOBP%GO:1902823	negative regulation of late endosome to lysosome transport	0.0353200074405027	0.0353200074405027	+1	LRRK2
REGULATION OF BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS%GOBP%GO:0060693	regulation of branching involved in salivary gland morphogenesis	0.0353200074405027	0.0353200074405027	+1	HGF
ACTIVATION OF PHOSPHOLIPASE A2 ACTIVITY BY CALCIUM-MEDIATED SIGNALING%GOBP%GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling	0.0353200074405027	0.0353200074405027	+1	EGFR
CANONICAL WNT SIGNALING PATHWAY INVOLVED IN POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION%GOBP%GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	0.0353200074405027	0.0353200074405027	+1	CTNNB1
POSITIVE REGULATION OF WOUND HEALING, SPREADING OF EPIDERMAL CELLS%GOBP%GO:1903691	positive regulation of wound healing, spreading of epidermal cells	0.0353200074405027	0.0353200074405027	+1	MTOR
EPITHELIAL CELL PROLIFERATION INVOLVED IN SALIVARY GLAND MORPHOGENESIS%GOBP%GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	0.0353200074405027	0.0353200074405027	+1	FGFR2
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 69%9013508	NOTCH3 Intracellular Domain Regulates Transcription	0.0353200074405027	0.0353200074405027	+1	NOTCH1,EP300
NEGATIVE REGULATION OF APOPTOTIC PROCESS IN BONE MARROW%GOBP%GO:0071866	negative regulation of apoptotic process in bone marrow	0.0353200074405027	0.0353200074405027	+1	FGFR2
REGULATION OF GLUCOSE METABOLIC PROCESS%GOBP%GO:0010906	regulation of glucose metabolic process	0.0353200074405027	0.0353200074405027	+1	AKT1,EP300,FOXA2
REGULATION OF MAINTENANCE OF MITOTIC SISTER CHROMATID COHESION, TELOMERIC%GOBP%GO:1904907	regulation of maintenance of mitotic sister chromatid cohesion, telomeric	0.0353200074405027	0.0353200074405027	+1	ATRX
TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 69%3642279	TGFBR2 MSI Frameshift Mutants in Cancer	0.0353200074405027	0.0353200074405027	+1	TGFBR2
NEGATIVE REGULATION OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR SIGNALING PATHWAY%GOBP%GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	0.0353200074405027	0.0353200074405027	+1	ASXL1
REGULATION OF CELL PROLIFERATION INVOLVED IN OUTFLOW TRACT MORPHOGENESIS%GOBP%GO:1901963	regulation of cell proliferation involved in outflow tract morphogenesis	0.0353200074405027	0.0353200074405027	+1	CTNNB1
NEGATIVE REGULATION OF MAINTENANCE OF MITOTIC SISTER CHROMATID COHESION, TELOMERIC%GOBP%GO:1904908	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	0.0353200074405027	0.0353200074405027	+1	ATRX
REGULATION OF METANEPHRIC GLOMERULAR MESANGIAL CELL PROLIFERATION%GOBP%GO:0072301	regulation of metanephric glomerular mesangial cell proliferation	0.0353200074405027	0.0353200074405027	+1	WT1
REGULATION OF MITOTIC CELL CYCLE DNA REPLICATION%GOBP%GO:1903463	regulation of mitotic cell cycle DNA replication	0.0353200074405027	0.0353200074405027	+1	CHEK2
NEGATIVE REGULATION OF CELL PROLIFERATION INVOLVED IN HEART VALVE MORPHOGENESIS%GOBP%GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	0.0353200074405027	0.0353200074405027	+1	NOTCH1
POSITIVE REGULATION OF PRI-MIRNA TRANSCRIPTION BY RNA POLYMERASE II%GOBP%GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	0.0353200074405027	0.0353200074405027	+1	TP53,WT1
REGULATION OF REGULATORY T CELL DIFFERENTIATION%GOBP%GO:0045589	regulation of regulatory T cell differentiation	0.0353200074405027	0.0353200074405027	+1	RUNX1,CBFB
POSITIVE REGULATION OF B CELL TOLERANCE INDUCTION%GOBP%GO:0002663	positive regulation of B cell tolerance induction	0.0353200074405027	0.0353200074405027	+1	TGFBR2
CELLULAR RESPONSE TO STEM CELL FACTOR STIMULUS%GOBP%GO:0036216	cellular response to stem cell factor stimulus	0.0353200074405027	0.0353200074405027	+1	KIT
LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME%R-HSA-9022538.1	Loss of MECP2 binding ability to 5mC-DNA	0.0353200074405027	0.0353200074405027	+1	SIN3A
DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS	Downstream signaling in naive CD8+ T cells	0.0353200074405027	0.0353200074405027	+1	KRAS,NRAS,BRAF
CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 69%400253	Circadian Clock	0.0353200074405027	0.0353200074405027	+1	EP300,TBL1XR1,NCOR1
REGULATION OF ALPHA-BETA T CELL PROLIFERATION%GOBP%GO:0046640	regulation of alpha-beta T cell proliferation	0.0353200074405027	0.0353200074405027	+1	TGFBR2,MAPK8IP1
POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION%GOBP%GO:0010634	positive regulation of epithelial cell migration	0.0355978344334119	0.0355978344334119	+1	GATA3,AKT1,SOX9,MTOR
APPENDAGE DEVELOPMENT%GOBP%GO:0048736	appendage development	0.036290375507227454	0.036290375507227454	+1	CTNNB1,TBX3,FGFR2
CAMERA-TYPE EYE DEVELOPMENT%GOBP%GO:0043010	camera-type eye development	0.036290375507227454	0.036290375507227454	+1	NF1,SOX9,WT1,PDGFRA
REGULATION OF COAGULATION%GOBP%GO:0050818	regulation of coagulation	0.036290375507227454	0.036290375507227454	+1	TLR4,PDGFRA,FOXA2
PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY	PID_MYC_PATHWAY	0.036290375507227454	0.036290375507227454	+1	CDKN2A,FBXW7
BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY	BIOCARTA_STRESS_PATHWAY	0.036290375507227454	0.036290375507227454	+1	MAP3K1,MAP2K4
G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 69%392451	G beta:gamma signalling through PI3Kgamma	0.036290375507227454	0.036290375507227454	+1	AKT1,PIK3CG
REGULATION OF RESPONSE TO DRUG%GOBP%GO:2001023	regulation of response to drug	0.036290375507227454	0.036290375507227454	+1	NFE2L2,HGF,LRRK2
POSITIVE REGULATION OF SIGNALING RECEPTOR ACTIVITY%GOBP%GO:2000273	positive regulation of signaling receptor activity	0.036290375507227454	0.036290375507227454	+1	FBXW7,TAF1
OSSIFICATION%GOBP%GO:0001503	ossification	0.036290375507227454	0.036290375507227454	+1	EGFR,NF1,FGFR2,FGFR3
REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.1	Regulation of RAS by GAPs	0.036290375507227454	0.036290375507227454	+1	KRAS,NF1,NRAS
CHEMICAL SYNAPTIC TRANSMISSION, POSTSYNAPTIC%GOBP%GO:0099565	chemical synaptic transmission, postsynaptic	0.036290375507227454	0.036290375507227454	+1	AKT1,LRRK2
LIMB DEVELOPMENT%GOBP%GO:0060173	limb development	0.036290375507227454	0.036290375507227454	+1	CTNNB1,TBX3,FGFR2
DETERMINATION OF BILATERAL SYMMETRY%GOBP%GO:0009855	determination of bilateral symmetry	0.036290375507227454	0.036290375507227454	+1	NOTCH1,TGFBR2,SOX17
LEUKOCYTE HOMEOSTASIS%GOBP%GO:0001776	leukocyte homeostasis	0.036290375507227454	0.036290375507227454	+1	FLT3,AKT1
G2/M TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:0000086	G2/M transition of mitotic cell cycle	0.036290375507227454	0.036290375507227454	+1	AJUBA,CHEK2,CDKN1A,PPP2R1A
DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 69%2173788	Downregulation of TGF-beta receptor signaling	0.036290375507227454	0.036290375507227454	+1	TGFBR2,SMAD2
REGULATION OF STRESS-ACTIVATED MAPK CASCADE%GOBP%GO:0032872	regulation of stress-activated MAPK cascade	0.03730680437963351	0.03730680437963351	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
SPECIFICATION OF SYMMETRY%GOBP%GO:0009799	specification of symmetry	0.03746611396266196	0.03746611396266196	+1	NOTCH1,TGFBR2,SOX17
NEGATIVE REGULATION OF SMALL MOLECULE METABOLIC PROCESS%GOBP%GO:0062014	negative regulation of small molecule metabolic process	0.03746611396266196	0.03746611396266196	+1	AKT1,BRCA1,EP300
NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.1	Nonhomologous End-Joining (NHEJ)	0.03746611396266196	0.03746611396266196	+1	ATM,BRCA1,HIST1H2BD
REGULATION OF PROTEIN TARGETING%GOBP%GO:1903533	regulation of protein targeting	0.03746611396266196	0.03746611396266196	+1	FBXW7,BAP1,LRRK2
REGULATION OF HEMATOPOIETIC STEM CELL DIFFERENTIATION%GOBP%GO:1902036	regulation of hematopoietic stem cell differentiation	0.03746611396266196	0.03746611396266196	+1	GATA3,RUNX1,CBFB
DOUBLE-STRAND BREAK REPAIR VIA NONHOMOLOGOUS END JOINING%GOBP%GO:0006303	double-strand break repair via nonhomologous end joining	0.03746611396266196	0.03746611396266196	+1	ATM,BRCA1,POLQ
REGULATION OF STRESS-ACTIVATED PROTEIN KINASE SIGNALING CASCADE%GOBP%GO:0070302	regulation of stress-activated protein kinase signaling cascade	0.03795159288017781	0.03795159288017781	+1	EGFR,MAP2K4,MAPK8IP1,MECOM,NCOR1
CELL CYCLE G2/M PHASE TRANSITION%GOBP%GO:0044839	cell cycle G2/M phase transition	0.03810330677698909	0.03810330677698909	+1	AJUBA,CHEK2,CDKN1A,PPP2R1A
PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY	PID_P38_MKK3_6PATHWAY	0.0386409511088365	0.0386409511088365	+1	MAP3K1,ATM
G2 DNA DAMAGE CHECKPOINT%GOBP%GO:0031572	G2 DNA damage checkpoint	0.0386409511088365	0.0386409511088365	+1	ATM,BRCA1
BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY	BIOCARTA_VIP_PATHWAY	0.0386409511088365	0.0386409511088365	+1	MAP3K1,EGR3
EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20190610%WP581%HOMO SAPIENS	http://www.wikipathways.org/instance/WP581_r86897	0.0386409511088365	0.0386409511088365	+1	AKT1,PIK3CG
NEGATIVE REGULATION OF SYNAPTIC TRANSMISSION%GOBP%GO:0050805	negative regulation of synaptic transmission	0.0386409511088365	0.0386409511088365	+1	PTEN,LRRK2
CD40%IOB%CD40	CD40	0.0386409511088365	0.0386409511088365	+1	PIK3R1,AKT1
FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 69%1839124	FGFR1 mutant receptor activation	0.0386409511088365	0.0386409511088365	+1	PIK3CA,PIK3R1
POSITIVE REGULATION OF CHROMOSOME SEGREGATION%GOBP%GO:0051984	positive regulation of chromosome segregation	0.0386409511088365	0.0386409511088365	+1	RB1,RAD21
REGULATION OF INTERFERON-ALPHA PRODUCTION%GOBP%GO:0032647	regulation of interferon-alpha production	0.0386409511088365	0.0386409511088365	+1	TLR4,SETD2
ST_INTERLEUKIN_4_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_4_PATHWAY	ST_INTERLEUKIN_4_PATHWAY	0.0386409511088365	0.0386409511088365	+1	PIK3CA,AKT1
GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK	Glypican 1 network	0.0386409511088365	0.0386409511088365	+1	TGFBR2,SMAD2
POSITIVE REGULATION OF PEPTIDYL-LYSINE ACETYLATION%GOBP%GO:2000758	positive regulation of peptidyl-lysine acetylation	0.0386409511088365	0.0386409511088365	+1	BRCA1,SMAD4
NEGATIVE REGULATION OF ENDOTHELIAL CELL APOPTOTIC PROCESS%GOBP%GO:2000352	negative regulation of endothelial cell apoptotic process	0.0386409511088365	0.0386409511088365	+1	GATA3,NFE2L2
FOREBRAIN GENERATION OF NEURONS%GOBP%GO:0021872	forebrain generation of neurons	0.0386409511088365	0.0386409511088365	+1	ERBB4,FGFR2
C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY	C-MYC pathway	0.0386409511088365	0.0386409511088365	+1	CDKN2A,FBXW7
INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 69%912526	Interleukin receptor SHC signaling	0.0386409511088365	0.0386409511088365	+1	PIK3CA,PIK3R1
MYELOID CELL DIFFERENTIATION%GOBP%GO:0030099	myeloid cell differentiation	0.038799466436381394	0.038799466436381394	+1	CEBPA,TET2,KIT,TGFBR2
WNT SIGNALING PATHWAY%GOBP%GO:0016055	Wnt signaling pathway	0.039167625601330615	0.039167625601330615	+1	PTEN,APC,GATA3,CTNNB1,LRRK2
RESPONSE TO STARVATION%GOBP%GO:0042594	response to starvation	0.03977893283158063	0.03977893283158063	+1	TP53,MTOR,LRRK2,CDKN1A
BMP SIGNALING PATHWAY%GOBP%GO:0030509	BMP signaling pathway	0.03996229503953499	0.03996229503953499	+1	SMAD4,USP9X,ACVR2A
MYELOID LEUKOCYTE DIFFERENTIATION%GOBP%GO:0002573	myeloid leukocyte differentiation	0.03996229503953499	0.03996229503953499	+1	CEBPA,KIT,TGFBR2
NON-GENOMIC ACTIONS OF 1,25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20190610%WP4341%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4341_r98497	0.03996229503953499	0.03996229503953499	+1	KRAS,NRAS,TLR4
CELL-CELL SIGNALING BY WNT%GOBP%GO:0198738	cell-cell signaling by wnt	0.04066880196636238	0.04066880196636238	+1	PTEN,APC,GATA3,CTNNB1,LRRK2
FOLLICLE STIMULATING HORMONE (FSH) SIGNALING PATHWAY%WIKIPATHWAYS_20190610%WP2035%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2035_r101857	0.04117379807277006	0.04117379807277006	+1	AKT1,MTOR
ST_MYOCYTE_AD_PATHWAY%MSIGDB_C2%ST_MYOCYTE_AD_PATHWAY	ST_MYOCYTE_AD_PATHWAY	0.04117379807277006	0.04117379807277006	+1	APC,AKT1
PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY	PID_GLYPICAN_1PATHWAY	0.04117379807277006	0.04117379807277006	+1	TGFBR2,SMAD2
POSITIVE REGULATION OF EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	0.04117379807277006	0.04117379807277006	+1	FBXW7,AKT1
CELLULAR RESPONSE TO CADMIUM ION%GOBP%GO:0071276	cellular response to cadmium ion	0.04117379807277006	0.04117379807277006	+1	EGFR,AKT1
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.2	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	0.04117379807277006	0.04117379807277006	+1	KRAS,NRAS
POSITIVE REGULATION OF INTERFERON-BETA PRODUCTION%GOBP%GO:0032728	positive regulation of interferon-beta production	0.04117379807277006	0.04117379807277006	+1	TLR4,PTPN11
POSITIVE REGULATION OF EMBRYONIC DEVELOPMENT%GOBP%GO:0040019	positive regulation of embryonic development	0.04117379807277006	0.04117379807277006	+1	GATA3,FOXA2
DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 69%8863795	Downregulation of ERBB2 signaling	0.04117379807277006	0.04117379807277006	+1	EGFR,AKT1
REGULATION OF ORGANIC ACID TRANSPORT%GOBP%GO:0032890	regulation of organic acid transport	0.04117379807277006	0.04117379807277006	+1	AKT1,NCOR1
POSITIVE REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS%GOBP%GO:0045429	positive regulation of nitric oxide biosynthetic process	0.04117379807277006	0.04117379807277006	+1	AKT1,TLR4
STEROL REGULATORY ELEMENT-BINDING PROTEINS (SREBP) SIGNALLING%WIKIPATHWAYS_20190610%WP1982%HOMO SAPIENS	http://www.wikipathways.org/instance/WP1982_r90425	0.04119750079225697	0.04119750079225697	+1	PIK3CA,AKT1,MTOR
B CELL DIFFERENTIATION%GOBP%GO:0030183	B cell differentiation	0.04119750079225697	0.04119750079225697	+1	FLT3,ATM,KIT
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-HSA-8939236.1	RUNX1 regulates transcription of genes involved in differentiation of HSCs	0.041509584986841326	0.041509584986841326	+1	GATA3,RUNX1,CBFB,HIST1H2BD
NEGATIVE REGULATION OF BINDING%GOBP%GO:0051100	negative regulation of binding	0.04252661541706572	0.04252661541706572	+1	AKT1,LRRK2,TAF1,SIN3A
NEGATIVE REGULATION OF CELL-CELL ADHESION%GOBP%GO:0022408	negative regulation of cell-cell adhesion	0.04252661541706572	0.04252661541706572	+1	CDH1,RUNX1,AKT1,CBFB
CENTROSOME CYCLE%GOBP%GO:0007098	centrosome cycle	0.042605149475312604	0.042605149475312604	+1	CTNNB1,NPM1,BRCA2
REGULATION OF TRANSLATIONAL INITIATION%GOBP%GO:0006446	regulation of translational initiation	0.042605149475312604	0.042605149475312604	+1	NPM1,MTOR,EIF4A2
PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 69%212300	PRC2 methylates histones and DNA	0.042605149475312604	0.042605149475312604	+1	DNMT3A,HIST1H2BD,EZH2
NEGATIVE REGULATION OF CELL ACTIVATION%GOBP%GO:0050866	negative regulation of cell activation	0.04349766485831687	0.04349766485831687	+1	RUNX1,ATM,PDGFRA,CBFB
MRNA PROCESSING%WIKIPATHWAYS_20190610%WP411%HOMO SAPIENS	http://www.wikipathways.org/instance/WP411_r102226	0.04349766485831687	0.04349766485831687	+1	U2AF1,SF3B1,SMC1A,SPOP
HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_LATE	HALLMARK_ESTROGEN_RESPONSE_LATE	0.04353362866927002	0.04353362866927002	+1	CDH1,IDH2,CCND1,FGFR3,EGR3
PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY	PID_IL8_CXCR1_PATHWAY	0.043549644742068745	0.043549644742068745	+1	AKT1,PIK3CG
MESODERM MORPHOGENESIS%GOBP%GO:0048332	mesoderm morphogenesis	0.043549644742068745	0.043549644742068745	+1	TBX3,SMAD2
BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY	BIOCARTA_PYK2_PATHWAY	0.043549644742068745	0.043549644742068745	+1	MAP3K1,MAP2K4
REGULATION OF PLATELET ACTIVATION%GOBP%GO:0010543	regulation of platelet activation	0.043549644742068745	0.043549644742068745	+1	TLR4,PDGFRA
POSITIVE REGULATION OF PROTEIN IMPORT INTO NUCLEUS%GOBP%GO:0042307	positive regulation of protein import into nucleus	0.043549644742068745	0.043549644742068745	+1	PIK3R1,CDH1
GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20190610%WP2361%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2361_r101906	0.043549644742068745	0.043549644742068745	+1	APC,NOTCH1
REGULATION OF PROTEIN EXPORT FROM NUCLEUS%GOBP%GO:0046825	regulation of protein export from nucleus	0.043549644742068745	0.043549644742068745	+1	TP53,SETD2
IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS	IL8- and CXCR1-mediated signaling events	0.043549644742068745	0.043549644742068745	+1	AKT1,PIK3CG
IL-7%NETPATH%IL-7	IL-7	0.043549644742068745	0.043549644742068745	+1	PIK3R1,AKT1
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 69%380972	Energy dependent regulation of mTOR by LKB1-AMPK	0.043549644742068745	0.043549644742068745	+1	STK11,MTOR
INNER EAR MORPHOGENESIS%GOBP%GO:0042472	inner ear morphogenesis	0.043549644742068745	0.043549644742068745	+1	SOX9,FGFR2
REGULATION OF CARDIOCYTE DIFFERENTIATION%GOBP%GO:1905207	regulation of cardiocyte differentiation	0.043549644742068745	0.043549644742068745	+1	EGFR,SMAD4
SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 69%201451	Signaling by BMP	0.043549644742068745	0.043549644742068745	+1	SMAD4,ACVR2A
BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY	BIOCARTA_ERK_PATHWAY	0.043549644742068745	0.043549644742068745	+1	EGFR,PDGFRA
POSITIVE REGULATION OF NITRIC OXIDE METABOLIC PROCESS%GOBP%GO:1904407	positive regulation of nitric oxide metabolic process	0.043549644742068745	0.043549644742068745	+1	AKT1,TLR4
LIMBIC SYSTEM DEVELOPMENT%GOBP%GO:0021761	limbic system development	0.043549644742068745	0.043549644742068745	+1	PTEN,FGFR2
FEMALE GONAD DEVELOPMENT%GOBP%GO:0008585	female gonad development	0.043549644742068745	0.043549644742068745	+1	KIT,PDGFRA
REGULATION OF RESPONSE TO ENDOPLASMIC RETICULUM STRESS%GOBP%GO:1905897	regulation of response to endoplasmic reticulum stress	0.04367189458008788	0.04367189458008788	+1	PIK3R1,NFE2L2,LRRK2
POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION%GOBP%GO:0001938	positive regulation of endothelial cell proliferation	0.04367189458008788	0.04367189458008788	+1	NRAS,AKT1,EGR3
REGULATION OF BIOMINERAL TISSUE DEVELOPMENT%GOBP%GO:0070167	regulation of biomineral tissue development	0.04367189458008788	0.04367189458008788	+1	NOTCH1,SOX9,ACVR2A
FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0008543	fibroblast growth factor receptor signaling pathway	0.04367189458008788	0.04367189458008788	+1	FGFR2,FGFR3,PTPN11
HALLMARK_HYPOXIA%MSIGDB_C2%HALLMARK_HYPOXIA	HALLMARK_HYPOXIA	0.04391191132242394	0.04391191132242394	+1	VHL,EGFR,MAP3K1,CDKN1B,CDKN1A
LEUKOCYTE DIFFERENTIATION%GOBP%GO:0002521	leukocyte differentiation	0.04391191132242394	0.04391191132242394	+1	FLT3,CEBPA,ATM,KIT,TGFBR2
RESPONSE TO INSULIN%GOBP%GO:0032868	response to insulin	0.04403247144138215	0.04403247144138215	+1	PIK3CA,APC,PIK3R1,AKT1
REGULATION OF CYTOKINE-MEDIATED SIGNALING PATHWAY%GOBP%GO:0001959	regulation of cytokine-mediated signaling pathway	0.04403247144138215	0.04403247144138215	+1	RUNX1,CBFB,PTPN11,LIFR
PROTEIN DEPHOSPHORYLATION%GOBP%GO:0006470	protein dephosphorylation	0.04403247144138215	0.04403247144138215	+1	PTEN,STK11,PPP2R1A,PTPN11
NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	0.0450731784956096	0.0450731784956096	+1	AKT1,AR,BRCA1
CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 69%1234174	Cellular response to hypoxia	0.0450731784956096	0.0450731784956096	+1	VHL,AJUBA,EP300
GLIAL CELL DIFFERENTIATION%GOBP%GO:0010001	glial cell differentiation	0.0450731784956096	0.0450731784956096	+1	PTEN,NF1,SOX9
DEVELOPMENT OF PRIMARY FEMALE SEXUAL CHARACTERISTICS%GOBP%GO:0046545	development of primary female sexual characteristics	0.046053063341516466	0.046053063341516466	+1	KIT,PDGFRA
POSITIVE REGULATION OF ERBB SIGNALING PATHWAY%GOBP%GO:1901186	positive regulation of ERBB signaling pathway	0.046053063341516466	0.046053063341516466	+1	FBXW7,AKT1
REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION%GOBP%GO:1903053	regulation of extracellular matrix organization	0.046053063341516466	0.046053063341516466	+1	RB1,NOTCH1
P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY	p38 MAPK signaling pathway	0.046053063341516466	0.046053063341516466	+1	MAP3K1,ATM
MYD88-DEPENDENT TOLL-LIKE RECEPTOR SIGNALING PATHWAY%GOBP%GO:0002755	MyD88-dependent toll-like receptor signaling pathway	0.046053063341516466	0.046053063341516466	+1	MAP3K1,TLR4
ACTIVATION OF PROTEIN KINASE B ACTIVITY%GOBP%GO:0032148	activation of protein kinase B activity	0.046053063341516466	0.046053063341516466	+1	AKT1,MTOR
NEGATIVE REGULATION OF MICROTUBULE POLYMERIZATION OR DEPOLYMERIZATION%GOBP%GO:0031111	negative regulation of microtubule polymerization or depolymerization	0.046053063341516466	0.046053063341516466	+1	APC,NAV3
NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045	Notch signaling pathway	0.046053063341516466	0.046053063341516466	+1	NOTCH1,FBXW7
SEGMENTATION%GOBP%GO:0035282	segmentation	0.046053063341516466	0.046053063341516466	+1	TBX3,WT1
NEGATIVE REGULATION OF CELLULAR CARBOHYDRATE METABOLIC PROCESS%GOBP%GO:0010677	negative regulation of cellular carbohydrate metabolic process	0.046053063341516466	0.046053063341516466	+1	EP300,FOXA2
POSITIVE REGULATION OF FIBROBLAST PROLIFERATION%GOBP%GO:0048146	positive regulation of fibroblast proliferation	0.046053063341516466	0.046053063341516466	+1	PDGFRA,CDKN1A
NON-RECOMBINATIONAL REPAIR%GOBP%GO:0000726	non-recombinational repair	0.04641004372169746	0.04641004372169746	+1	ATM,BRCA1,POLQ
HISTONE H3-K27 METHYLATION%GOBP%GO:0070734	histone H3-K27 methylation	0.04730971041225413	0.04730971041225413	+1	EZH2
NEGATIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY%GOBP%GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	0.04730971041225413	0.04730971041225413	+1	NFE2L2,AKT1,LRRK2
EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.1	Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	0.04730971041225413	0.04730971041225413	+1	CDKN2A
DETECTION OF LIPOPOLYSACCHARIDE%GOBP%GO:0032497	detection of lipopolysaccharide	0.04730971041225413	0.04730971041225413	+1	TLR4
NEGATIVE REGULATION OF TRANSCRIPTION INVOLVED IN G1/S TRANSITION OF MITOTIC CELL CYCLE%GOBP%GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	0.04730971041225413	0.04730971041225413	+1	RB1
REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION%GOBP%GO:0043535	regulation of blood vessel endothelial cell migration	0.04730971041225413	0.04730971041225413	+1	NF1,NOTCH1,AKT1
MAST CELL MIGRATION%GOBP%GO:0097531	mast cell migration	0.04730971041225413	0.04730971041225413	+1	KIT
5-METHYLCYTOSINE METABOLIC PROCESS%GOBP%GO:0019857	5-methylcytosine metabolic process	0.04730971041225413	0.04730971041225413	+1	TET2
NEGATIVE REGULATION OF PRO-B CELL DIFFERENTIATION%GOBP%GO:2000974	negative regulation of pro-B cell differentiation	0.04730971041225413	0.04730971041225413	+1	NOTCH1
NEGATIVE REGULATION OF MAINTENANCE OF MITOTIC SISTER CHROMATID COHESION%GOBP%GO:0034183	negative regulation of maintenance of mitotic sister chromatid cohesion	0.04730971041225413	0.04730971041225413	+1	ATRX
LUTEINIZATION%GOBP%GO:0001553	luteinization	0.04730971041225413	0.04730971041225413	+1	PDGFRA
DNA MODIFICATION%GOBP%GO:0006304	DNA modification	0.04730971041225413	0.04730971041225413	+1	DNMT3A,TET2,ATRX
ENDOCARDIUM FORMATION%GOBP%GO:0060214	endocardium formation	0.04730971041225413	0.04730971041225413	+1	SOX17
POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER BY GLUCOSE%GOBP%GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	0.04730971041225413	0.04730971041225413	+1	FOXA2
ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS	AlphaE beta7 integrin cell surface interactions	0.04730971041225413	0.04730971041225413	+1	CDH1
NADPH REGENERATION%GOBP%GO:0006740	NADPH regeneration	0.04730971041225413	0.04730971041225413	+1	IDH1
T-CELL RECEPTOR AND CO-STIMULATORY SIGNALING%WIKIPATHWAYS_20190610%WP2583%HOMO SAPIENS	http://www.wikipathways.org/instance/WP2583_r97638	0.04730971041225413	0.04730971041225413	+1	PTEN,AKT1
REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER BY GLUCOSE%GOBP%GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose	0.04730971041225413	0.04730971041225413	+1	FOXA2
NUCLEOSOME MOBILIZATION%GOBP%GO:0042766	nucleosome mobilization	0.04730971041225413	0.04730971041225413	+1	ARID1A
EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 69%9632693	Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	0.04730971041225413	0.04730971041225413	+1	CDKN2A
POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION INVOLVED IN LUNG MORPHOGENESIS%GOBP%GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	0.04730971041225413	0.04730971041225413	+1	FGFR2
REGULATION OF REPRODUCTIVE PROCESS%GOBP%GO:2000241	regulation of reproductive process	0.04730971041225413	0.04730971041225413	+1	SOX9,WT1,ACVR1B
NEGATIVE REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS%GOBP%GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis	0.04730971041225413	0.04730971041225413	+1	NOTCH1
POSITIVE REGULATION OF CELLULAR RESPONSE TO MACROPHAGE COLONY-STIMULATING FACTOR STIMULUS%GOBP%GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	0.04730971041225413	0.04730971041225413	+1	TLR4
ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.2	Activation of BH3-only proteins	0.04730971041225413	0.04730971041225413	+1	TP53,AKT1
PRO-B CELL DIFFERENTIATION%GOBP%GO:0002328	pro-B cell differentiation	0.04730971041225413	0.04730971041225413	+1	FLT3
NEPHRIC DUCT FORMATION%GOBP%GO:0072179	nephric duct formation	0.04730971041225413	0.04730971041225413	+1	GATA3
5-METHYLCYTOSINE CATABOLIC PROCESS%GOBP%GO:0006211	5-methylcytosine catabolic process	0.04730971041225413	0.04730971041225413	+1	TET2
MESONEPHRIC TUBULE FORMATION%GOBP%GO:0072172	mesonephric tubule formation	0.04730971041225413	0.04730971041225413	+1	GATA3
HISTONE H3-K36 DIMETHYLATION%GOBP%GO:0097676	histone H3-K36 dimethylation	0.04730971041225413	0.04730971041225413	+1	SETD2
ERYTHROPOIETIN-MEDIATED SIGNALING PATHWAY%GOBP%GO:0038162	erythropoietin-mediated signaling pathway	0.04730971041225413	0.04730971041225413	+1	KIT
MITRAL VALVE FORMATION%GOBP%GO:0003192	mitral valve formation	0.04730971041225413	0.04730971041225413	+1	NOTCH1
SISTER CHROMATID BIORIENTATION%GOBP%GO:0031134	sister chromatid biorientation	0.04730971041225413	0.04730971041225413	+1	RB1
METANEPHRIC GLOMERULUS MORPHOGENESIS%GOBP%GO:0072275	metanephric glomerulus morphogenesis	0.04730971041225413	0.04730971041225413	+1	PDGFRA
RESPONSE TO CADMIUM ION%GOBP%GO:0046686	response to cadmium ion	0.04730971041225413	0.04730971041225413	+1	EGFR,AKT1
MAST CELL CHEMOTAXIS%GOBP%GO:0002551	mast cell chemotaxis	0.04730971041225413	0.04730971041225413	+1	KIT
REGULATION OF TELOMERE MAINTENANCE%GOBP%GO:0032204	regulation of telomere maintenance	0.04730971041225413	0.04730971041225413	+1	ATM,ATRX,ATR
LACRIMAL GLAND DEVELOPMENT%GOBP%GO:0032808	lacrimal gland development	0.04730971041225413	0.04730971041225413	+1	FGFR2
EPITHELIAL CELL DIFFERENTIATION INVOLVED IN PROSTATE GLAND DEVELOPMENT%GOBP%GO:0060742	epithelial cell differentiation involved in prostate gland development	0.04730971041225413	0.04730971041225413	+1	FGFR2
MODEL FOR REGULATION OF MSMP EXPRESSION IN CANCER CELLS AND ITS PROANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20190610%WP4397%HOMO SAPIENS	http://www.wikipathways.org/instance/WP4397_r98987	0.04730971041225413	0.04730971041225413	+1	CTCF
EMBRYONIC SKELETAL LIMB JOINT MORPHOGENESIS%GOBP%GO:0036023	embryonic skeletal limb joint morphogenesis	0.04730971041225413	0.04730971041225413	+1	CTNNB1
CELL MIGRATION INVOLVED IN ENDOCARDIAL CUSHION FORMATION%GOBP%GO:0003273	cell migration involved in endocardial cushion formation	0.04730971041225413	0.04730971041225413	+1	NOTCH1
NEURAL CREST CELL FATE COMMITMENT%GOBP%GO:0014034	neural crest cell fate commitment	0.04730971041225413	0.04730971041225413	+1	SOX9
NEGATIVE REGULATION OF LYMPHOID PROGENITOR CELL DIFFERENTIATION%GOBP%GO:1905457	negative regulation of lymphoid progenitor cell differentiation	0.04730971041225413	0.04730971041225413	+1	NOTCH1
REGULATION OF TRANSCRIPTION BY RNA POLYMERASE I%GOBP%GO:0006356	regulation of transcription by RNA polymerase I	0.04730971041225413	0.04730971041225413	+1	MTOR,TAF1
MEIOTIC CELL CYCLE%GOBP%GO:0051321	meiotic cell cycle	0.04730971041225413	0.04730971041225413	+1	ATM,SMC1A,SMC3,RAD21
POSITIVE REGULATION OF TRAIL-ACTIVATED APOPTOTIC SIGNALING PATHWAY%GOBP%GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	0.04730971041225413	0.04730971041225413	+1	PTEN
FASCICULATION OF SENSORY NEURON AXON%GOBP%GO:0097155	fasciculation of sensory neuron axon	0.04730971041225413	0.04730971041225413	+1	EPHA3
NEGATIVE REGULATION OF PROTEIN NEDDYLATION%GOBP%GO:2000435	negative regulation of protein neddylation	0.04730971041225413	0.04730971041225413	+1	RPL5
REGULATION OF SREBP SIGNALING PATHWAY%GOBP%GO:2000638	regulation of SREBP signaling pathway	0.04730971041225413	0.04730971041225413	+1	FBXW7
NEGATIVE REGULATION OF MESONEPHROS DEVELOPMENT%GOBP%GO:0061218	negative regulation of mesonephros development	0.04730971041225413	0.04730971041225413	+1	GATA3
NEGATIVE REGULATION OF GLOMERULUS DEVELOPMENT%GOBP%GO:0090194	negative regulation of glomerulus development	0.04730971041225413	0.04730971041225413	+1	WT1
REGULATION OF LATE ENDOSOME TO LYSOSOME TRANSPORT%GOBP%GO:1902822	regulation of late endosome to lysosome transport	0.04730971041225413	0.04730971041225413	+1	LRRK2
POSITIVE REGULATION OF T CELL TOLERANCE INDUCTION%GOBP%GO:0002666	positive regulation of T cell tolerance induction	0.04730971041225413	0.04730971041225413	+1	TGFBR2
GROWTH INVOLVED IN HEART MORPHOGENESIS%GOBP%GO:0003241	growth involved in heart morphogenesis	0.04730971041225413	0.04730971041225413	+1	NOTCH1
VEGF-ACTIVATED PLATELET-DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway	0.04730971041225413	0.04730971041225413	+1	PDGFRA
NEGATIVE REGULATION OF GONAD DEVELOPMENT%GOBP%GO:1905940	negative regulation of gonad development	0.04730971041225413	0.04730971041225413	+1	WT1
NEGATIVE REGULATION OF GROWTH RATE%GOBP%GO:0045967	negative regulation of growth rate	0.04730971041225413	0.04730971041225413	+1	NOTCH1
LIMB JOINT MORPHOGENESIS%GOBP%GO:0036022	limb joint morphogenesis	0.04730971041225413	0.04730971041225413	+1	CTNNB1
CENTRAL NERVOUS SYSTEM MYELIN MAINTENANCE%GOBP%GO:0032286	central nervous system myelin maintenance	0.04730971041225413	0.04730971041225413	+1	PTEN
LEUKEMIA INHIBITORY FACTOR SIGNALING PATHWAY%GOBP%GO:0048861	leukemia inhibitory factor signaling pathway	0.04730971041225413	0.04730971041225413	+1	LIFR
REGULATION OF PHOTORECEPTOR CELL DIFFERENTIATION%GOBP%GO:0046532	regulation of photoreceptor cell differentiation	0.04730971041225413	0.04730971041225413	+1	SOX9
BRANCHING MORPHOGENESIS OF A NERVE%GOBP%GO:0048755	branching morphogenesis of a nerve	0.04730971041225413	0.04730971041225413	+1	FGFR2
NEGATIVE REGULATION OF GLOMERULAR MESANGIAL CELL PROLIFERATION%GOBP%GO:0072125	negative regulation of glomerular mesangial cell proliferation	0.04730971041225413	0.04730971041225413	+1	WT1
POSITIVE REGULATION OF THYROID HORMONE GENERATION%GOBP%GO:2000611	positive regulation of thyroid hormone generation	0.04730971041225413	0.04730971041225413	+1	GATA3
REGULATION OF MITOTIC CELL CYCLE, EMBRYONIC%GOBP%GO:0009794	regulation of mitotic cell cycle, embryonic	0.04730971041225413	0.04730971041225413	+1	CTNNB1
NEGATIVE REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION%GOBP%GO:0002762	negative regulation of myeloid leukocyte differentiation	0.04730971041225413	0.04730971041225413	+1	FBXW7,TLR4
POSITIVE REGULATION OF MACROPHAGE APOPTOTIC PROCESS%GOBP%GO:2000111	positive regulation of macrophage apoptotic process	0.04730971041225413	0.04730971041225413	+1	CDKN2A
NEGATIVE REGULATION OF TAU-PROTEIN KINASE ACTIVITY%GOBP%GO:1902948	negative regulation of tau-protein kinase activity	0.04730971041225413	0.04730971041225413	+1	RB1
POSITIVE REGULATION OF TRANSCRIPTION BY GLUCOSE%GOBP%GO:0046016	positive regulation of transcription by glucose	0.04730971041225413	0.04730971041225413	+1	FOXA2
POSITIVE REGULATION OF PROTEOGLYCAN BIOSYNTHETIC PROCESS%GOBP%GO:1902730	positive regulation of proteoglycan biosynthetic process	0.04730971041225413	0.04730971041225413	+1	CTNNB1
POSITIVE REGULATION OF ANDROGEN RECEPTOR ACTIVITY%GOBP%GO:2000825	positive regulation of androgen receptor activity	0.04730971041225413	0.04730971041225413	+1	TAF1
NEGATIVE REGULATION OF FATTY ACID BETA-OXIDATION%GOBP%GO:0031999	negative regulation of fatty acid beta-oxidation	0.04730971041225413	0.04730971041225413	+1	AKT1
POSITIVE REGULATION OF UBIQUITIN-PROTEIN TRANSFERASE ACTIVITY%GOBP%GO:0051443	positive regulation of ubiquitin-protein transferase activity	0.04730971041225413	0.04730971041225413	+1	PTEN,FBXW7
REGULATION OF NK T CELL DIFFERENTIATION%GOBP%GO:0051136	regulation of NK T cell differentiation	0.04730971041225413	0.04730971041225413	+1	TGFBR2
POSITIVE REGULATION OF THYMOCYTE APOPTOTIC PROCESS%GOBP%GO:0070245	positive regulation of thymocyte apoptotic process	0.04730971041225413	0.04730971041225413	+1	TP53
NR1D1 (REV-ERBA) REPRESSES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 69%1368071	NR1D1 (REV-ERBA) represses gene expression	0.04730971041225413	0.04730971041225413	+1	NCOR1
REGULATION OF SYNAPTIC VESICLE CLUSTERING%GOBP%GO:2000807	regulation of synaptic vesicle clustering	0.04730971041225413	0.04730971041225413	+1	PTEN
REGULATION OF ANDROGEN RECEPTOR ACTIVITY%GOBP%GO:2000823	regulation of androgen receptor activity	0.04730971041225413	0.04730971041225413	+1	TAF1
REGULATION OF BRANCHING MORPHOGENESIS OF A NERVE%GOBP%GO:2000172	regulation of branching morphogenesis of a nerve	0.04730971041225413	0.04730971041225413	+1	LRRK2
WNT SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT%GOBP%GO:0003306	Wnt signaling pathway involved in heart development	0.04730971041225413	0.04730971041225413	+1	CTNNB1
REGULATION OF HEPARAN SULFATE PROTEOGLYCAN BIOSYNTHETIC PROCESS%GOBP%GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process	0.04730971041225413	0.04730971041225413	+1	CTNNB1
REGULATION OF RETROGRADE TRANSPORT, ENDOSOME TO GOLGI%GOBP%GO:1905279	regulation of retrograde transport, endosome to Golgi	0.04730971041225413	0.04730971041225413	+1	LRRK2
REGULATION OF CAMKK-AMPK SIGNALING CASCADE%GOBP%GO:1905289	regulation of CAMKK-AMPK signaling cascade	0.04730971041225413	0.04730971041225413	+1	LRRK2
CELLULAR RESPONSE TO ACTINOMYCIN D%GOBP%GO:0072717	cellular response to actinomycin D	0.04730971041225413	0.04730971041225413	+1	TP53
REGULATION OF THYROID HORMONE GENERATION%GOBP%GO:2000609	regulation of thyroid hormone generation	0.04730971041225413	0.04730971041225413	+1	GATA3
POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN UNFOLDED PROTEIN RESPONSE%GOBP%GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	0.04730971041225413	0.04730971041225413	+1	EP300
NEGATIVE REGULATION OF PHOTORECEPTOR CELL DIFFERENTIATION%GOBP%GO:0046533	negative regulation of photoreceptor cell differentiation	0.04730971041225413	0.04730971041225413	+1	SOX9
RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING	Retinoic acid receptors-mediated signaling	0.04730971041225413	0.04730971041225413	+1	AKT1,EP300
METANEPHRIC S-SHAPED BODY MORPHOGENESIS%GOBP%GO:0072284	metanephric S-shaped body morphogenesis	0.04730971041225413	0.04730971041225413	+1	WT1
POSITIVE REGULATION OF RESPONSE TO MACROPHAGE COLONY-STIMULATING FACTOR%GOBP%GO:1903971	positive regulation of response to macrophage colony-stimulating factor	0.04730971041225413	0.04730971041225413	+1	TLR4
MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 69%8875791	MET activates STAT3	0.04730971041225413	0.04730971041225413	+1	HGF
REGULATION OF CENTRIOLE-CENTRIOLE COHESION%GOBP%GO:0030997	regulation of centriole-centriole cohesion	0.04730971041225413	0.04730971041225413	+1	CTNNB1
PRE-B CELL ALLELIC EXCLUSION%GOBP%GO:0002331	pre-B cell allelic exclusion	0.04730971041225413	0.04730971041225413	+1	ATM
REGULATION OF VACUOLAR TRANSPORT%GOBP%GO:1903335	regulation of vacuolar transport	0.04730971041225413	0.04730971041225413	+1	LRRK2
POSITIVE REGULATION OF RETINOIC ACID RECEPTOR SIGNALING PATHWAY%GOBP%GO:0048386	positive regulation of retinoic acid receptor signaling pathway	0.04730971041225413	0.04730971041225413	+1	ASXL1
RESPONSE TO NITROSATIVE STRESS%GOBP%GO:0051409	response to nitrosative stress	0.04730971041225413	0.04730971041225413	+1	ATM
NATURAL KILLER CELL CHEMOTAXIS%GOBP%GO:0035747	natural killer cell chemotaxis	0.04730971041225413	0.04730971041225413	+1	PIK3CG
CARDIAC CELL FATE DETERMINATION%GOBP%GO:0060913	cardiac cell fate determination	0.04730971041225413	0.04730971041225413	+1	SOX17
COMMON-PARTNER SMAD PROTEIN PHOSPHORYLATION%GOBP%GO:0007182	common-partner SMAD protein phosphorylation	0.04730971041225413	0.04730971041225413	+1	SMAD2
DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.1	Diseases of Cellular Senescence	0.04730971041225413	0.04730971041225413	+1	CDKN2A
NEGATIVE REGULATION OF MAINTENANCE OF SISTER CHROMATID COHESION%GOBP%GO:0034092	negative regulation of maintenance of sister chromatid cohesion	0.04730971041225413	0.04730971041225413	+1	ATRX
POSITIVE REGULATION OF HEPARAN SULFATE PROTEOGLYCAN BIOSYNTHETIC PROCESS%GOBP%GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	0.04730971041225413	0.04730971041225413	+1	CTNNB1
HOMEOSTASIS OF NUMBER OF CELLS WITHIN A TISSUE%GOBP%GO:0048873	homeostasis of number of cells within a tissue	0.04730971041225413	0.04730971041225413	+1	SOX9
POSITIVE REGULATION OF APOPTOTIC PROCESS INVOLVED IN MORPHOGENESIS%GOBP%GO:1902339	positive regulation of apoptotic process involved in morphogenesis	0.04730971041225413	0.04730971041225413	+1	NOTCH1
POSITIVE REGULATION OF NITRIC OXIDE MEDIATED SIGNAL TRANSDUCTION%GOBP%GO:0010750	positive regulation of nitric oxide mediated signal transduction	0.04730971041225413	0.04730971041225413	+1	EGFR
LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME DATABASE ID RELEASE 69%3642278	Loss of Function of TGFBR2 in Cancer	0.04730971041225413	0.04730971041225413	+1	TGFBR2
EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.1	Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	0.04730971041225413	0.04730971041225413	+1	CDKN2A
REGULATION OF EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0042058	regulation of epidermal growth factor receptor signaling pathway	0.04730971041225413	0.04730971041225413	+1	EGFR,FBXW7,AKT1
N-TERMINAL PEPTIDYL-LYSINE ACETYLATION%GOBP%GO:0018076	N-terminal peptidyl-lysine acetylation	0.04730971041225413	0.04730971041225413	+1	EP300
RESPONSE TO FOLLICLE-STIMULATING HORMONE%GOBP%GO:0032354	response to follicle-stimulating hormone	0.04730971041225413	0.04730971041225413	+1	NOTCH1
SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCUS ASSEMBLY%GOBP%GO:0035986	senescence-associated heterochromatin focus assembly	0.04730971041225413	0.04730971041225413	+1	CDKN2A
POSITIVE REGULATION OF INTEGRIN BIOSYNTHETIC PROCESS%GOBP%GO:0045726	positive regulation of integrin biosynthetic process	0.04730971041225413	0.04730971041225413	+1	AR
EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 69%9630794	Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	0.04730971041225413	0.04730971041225413	+1	CDKN2A
POSITIVE REGULATION OF CELL PROLIFERATION BY VEGF-ACTIVATED PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY%GOBP%GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	0.04730971041225413	0.04730971041225413	+1	PDGFRA
ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 69%418990	Adherens junctions interactions	0.04730971041225413	0.04730971041225413	+1	CTNNB1,CDH1
PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY	PID_RETINOIC_ACID_PATHWAY	0.04730971041225413	0.04730971041225413	+1	AKT1,EP300
REGULATION OF CARDIAC MUSCLE HYPERTROPHY%GOBP%GO:0010611	regulation of cardiac muscle hypertrophy	0.04730971041225413	0.04730971041225413	+1	NOTCH1,SMAD4
REGULATION OF NEURON MATURATION%GOBP%GO:0014041	regulation of neuron maturation	0.04730971041225413	0.04730971041225413	+1	LRRK2
REPLICATION FORK PROCESSING%GOBP%GO:0031297	replication fork processing	0.04730971041225413	0.04730971041225413	+1	ATRX,BRCA2
REGULATION OF ENDORIBONUCLEASE ACTIVITY%GOBP%GO:0060699	regulation of endoribonuclease activity	0.04730971041225413	0.04730971041225413	+1	NPM1
POSITIVE REGULATION OF APOPTOTIC PROCESS INVOLVED IN DEVELOPMENT%GOBP%GO:1904747	positive regulation of apoptotic process involved in development	0.04730971041225413	0.04730971041225413	+1	NOTCH1
TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 69%3645790	TGFBR2 Kinase Domain Mutants in Cancer	0.04730971041225413	0.04730971041225413	+1	TGFBR2
POSITIVE REGULATION OF PROTEIN IMPORT%GOBP%GO:1904591	positive regulation of protein import	0.04730971041225413	0.04730971041225413	+1	PIK3R1,CDH1
REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO UV-INDUCED DNA DAMAGE%GOBP%GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	0.04730971041225413	0.04730971041225413	+1	TAF1
DOUBLE-STRAND BREAK REPAIR VIA ALTERNATIVE NONHOMOLOGOUS END JOINING%GOBP%GO:0097681	double-strand break repair via alternative nonhomologous end joining	0.04730971041225413	0.04730971041225413	+1	POLQ
METANEPHRIC GLOMERULUS VASCULATURE MORPHOGENESIS%GOBP%GO:0072276	metanephric glomerulus vasculature morphogenesis	0.04730971041225413	0.04730971041225413	+1	PDGFRA
METANEPHRIC GLOMERULAR CAPILLARY FORMATION%GOBP%GO:0072277	metanephric glomerular capillary formation	0.04730971041225413	0.04730971041225413	+1	PDGFRA
CANONICAL WNT SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT%GOBP%GO:0061316	canonical Wnt signaling pathway involved in heart development	0.04730971041225413	0.04730971041225413	+1	CTNNB1
REGULATION OF FAT CELL DIFFERENTIATION%GOBP%GO:0045598	regulation of fat cell differentiation	0.04847411208395596	0.04847411208395596	+1	GATA3,AKT1,ASXL1
REGULATION OF TORC1 SIGNALING%GOBP%GO:1903432	regulation of TORC1 signaling	0.04898387001177772	0.04898387001177772	+1	STK11,ATM
NEGATIVE REGULATION OF ALPHA-BETA T CELL ACTIVATION%GOBP%GO:0046636	negative regulation of alpha-beta T cell activation	0.04898387001177772	0.04898387001177772	+1	RUNX1,CBFB
REGULATION OF MUSCLE HYPERTROPHY%GOBP%GO:0014743	regulation of muscle hypertrophy	0.04898387001177772	0.04898387001177772	+1	NOTCH1,SMAD4
NEGATIVE REGULATION OF GENE SILENCING%GOBP%GO:0060969	negative regulation of gene silencing	0.04898387001177772	0.04898387001177772	+1	HIST1H1C,NCOR1
NEGATIVE REGULATION OF T CELL DIFFERENTIATION%GOBP%GO:0045581	negative regulation of T cell differentiation	0.04898387001177772	0.04898387001177772	+1	RUNX1,CBFB
NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION%GOBP%GO:0045599	negative regulation of fat cell differentiation	0.04898387001177772	0.04898387001177772	+1	GATA3,ASXL1
REGULATION OF KERATINOCYTE DIFFERENTIATION%GOBP%GO:0045616	regulation of keratinocyte differentiation	0.04898387001177772	0.04898387001177772	+1	RUNX1,CBFB
REGULATION OF DNA DAMAGE RESPONSE, SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR%GOBP%GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	0.04898387001177772	0.04898387001177772	+1	ATM,ATR
REGULATION OF GLIAL CELL DIFFERENTIATION%GOBP%GO:0045685	regulation of glial cell differentiation	0.04898387001177772	0.04898387001177772	+1	NF1,NOTCH1
ER-NUCLEUS SIGNALING PATHWAY%GOBP%GO:0006984	ER-nucleus signaling pathway	0.04898387001177772	0.04898387001177772	+1	TP53,NFE2L2
BIOMINERAL TISSUE DEVELOPMENT%GOBP%GO:0031214	biomineral tissue development	0.04898387001177772	0.04898387001177772	+1	FGFR2,FGFR3
NEGATIVE REGULATION OF HISTONE MODIFICATION%GOBP%GO:0031057	negative regulation of histone modification	0.04898387001177772	0.04898387001177772	+1	BRCA1,SIN3A
REGULATION OF ERYTHROCYTE DIFFERENTIATION%GOBP%GO:0045646	regulation of erythrocyte differentiation	0.04898387001177772	0.04898387001177772	+1	ACVR1B,ACVR2A
POSITIVE REGULATION OF PROTEIN TARGETING TO MITOCHONDRION%GOBP%GO:1903955	positive regulation of protein targeting to mitochondrion	0.04898387001177772	0.04898387001177772	+1	FBXW7,BAP1
POSITIVE REGULATION OF TRANSMEMBRANE TRANSPORT%GOBP%GO:0034764	positive regulation of transmembrane transport	0.04957703767749572	0.04957703767749572	+1	PIK3R1,AKT1,BRAF,PTPN11
REGULATION OF OXIDOREDUCTASE ACTIVITY%GOBP%GO:0051341	regulation of oxidoreductase activity	0.04974149034418157	0.04974149034418157	+1	EGFR,AKT1,LRRK2